760011:SPICO RS02220
gene id: 760011:SPICO_RS02220
uniprot id: F4GIG1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

760011:SPICO RS09360
gene id: 760011:SPICO_RS09360
uniprot id: F4GLZ2
names: Similarity
messages: Belongs to the peptidase S41A family.

760011:SPICO RS03065
gene id: 760011:SPICO_RS03065
uniprot id: F4GK61
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

760011:SPICO RS05635
gene id: 760011:SPICO_RS05635
uniprot id: F4GKC3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

760011:SPICO RS08645
gene id: 760011:SPICO_RS08645
uniprot id: F4GKL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

760011:SPICO RS07960
gene id: 760011:SPICO_RS07960
uniprot id: F4GJL5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

760011:SPICO RS07685
gene id: 760011:SPICO_RS07685
uniprot id: F4GIU1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

760011:SPICO RS03015
gene id: 760011:SPICO_RS03015
uniprot id: F4GK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

760011:SPICO RS01165
gene id: 760011:SPICO_RS01165
uniprot id: F4GKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

760011:SPICO RS04360
gene id: 760011:SPICO_RS04360
uniprot id: F4GHV6
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

760011:SPICO RS02935
gene id: 760011:SPICO_RS02935
uniprot id: F4GK36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

760011:SPICO RS08625
gene id: 760011:SPICO_RS08625
uniprot id: F4GKK6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

760011:SPICO RS05475
gene id: 760011:SPICO_RS05475
uniprot id: F4GK93
names: Similarity
messages: Belongs to the glycosyl hydrolase.

760011:SPICO RS07450
gene id: 760011:SPICO_RS07450
uniprot id: F4GI66
names: Similarity
messages: Belongs to the peptidase M20B family.

760011:SPICO RS02815
gene id: 760011:SPICO_RS02815
uniprot id: F4GK12
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

760011:SPICO RS07140
gene id: 760011:SPICO_RS07140
uniprot id: F4GHL3
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02325
gene id: 760011:SPICO_RS02325
uniprot id: F4GII0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

760011:SPICO RS04490
gene id: 760011:SPICO_RS04490
uniprot id: F4GHY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

760011:SPICO RS09490
gene id: 760011:SPICO_RS09490
uniprot id: F4GM78
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

760011:SPICO RS06780
gene id: 760011:SPICO_RS06780
uniprot id: F4GM55
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

760011:SPICO RS02675
gene id: 760011:SPICO_RS02675
uniprot id: F4GJB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

760011:SPICO RS03330
gene id: 760011:SPICO_RS03330
uniprot id: F4GKX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

760011:SPICO RS01325
gene id: 760011:SPICO_RS01325
uniprot id: F4GH26
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

760011:SPICO RS01820
gene id: 760011:SPICO_RS01820
uniprot id: F4GHQ6
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

760011:SPICO RS08945
gene id: 760011:SPICO_RS08945
uniprot id: F4GLC1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

760011:SPICO RS07845
gene id: 760011:SPICO_RS07845
uniprot id: F4GIX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

760011:SPICO RS02630
gene id: 760011:SPICO_RS02630
uniprot id: F4GJB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

760011:SPICO RS05685
gene id: 760011:SPICO_RS05685
uniprot id: F4GKD2
names: Similarity
messages: Belongs to the nitroreductase family.

760011:SPICO RS09005
gene id: 760011:SPICO_RS09005
uniprot id: F4GLD3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

760011:SPICO RS08025
gene id: 760011:SPICO_RS08025
uniprot id: F4GJM8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

760011:SPICO RS03180
gene id: 760011:SPICO_RS03180
uniprot id: F4GKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS02145
gene id: 760011:SPICO_RS02145
uniprot id: F4GIE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

760011:SPICO RS04930
gene id: 760011:SPICO_RS04930
uniprot id: F4GIP6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

760011:SPICO RS02580
gene id: 760011:SPICO_RS02580
uniprot id: F4GJ99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

760011:SPICO RS03990
gene id: 760011:SPICO_RS03990
uniprot id: F4GHA3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

760011:SPICO RS08735
gene id: 760011:SPICO_RS08735
uniprot id: F4GL81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

760011:SPICO RS05410
gene id: 760011:SPICO_RS05410
uniprot id: F4GK80
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01135
gene id: 760011:SPICO_RS01135
uniprot id: F4GKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

760011:SPICO RS08670
gene id: 760011:SPICO_RS08670
uniprot id: F4GKL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

760011:SPICO RS04440
gene id: 760011:SPICO_RS04440
uniprot id: F4GHX2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class II subfamily.
messages: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

760011:SPICO RS06910
gene id: 760011:SPICO_RS06910
uniprot id: F4GHG7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

760011:SPICO RS06370
gene id: 760011:SPICO_RS06370
uniprot id: F4GLQ9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

760011:SPICO RS03395
gene id: 760011:SPICO_RS03395
uniprot id: F4GKX9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

760011:SPICO RS07750
gene id: 760011:SPICO_RS07750
uniprot id: F4GIV4
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

760011:SPICO RS03950
gene id: 760011:SPICO_RS03950
uniprot id: F4GH95
names: Similarity
messages: Belongs to the glycosyl hydrolase.

760011:SPICO RS04705
gene id: 760011:SPICO_RS04705
uniprot id: F4GIK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

760011:SPICO RS08185
gene id: 760011:SPICO_RS08185
uniprot id: F4GJQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

760011:SPICO RS00540
gene id: 760011:SPICO_RS00540
uniprot id: F4GJ56
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02340
gene id: 760011:SPICO_RS02340
uniprot id: F4GII3
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

760011:SPICO RS05700
gene id: 760011:SPICO_RS05700
uniprot id: F4GKD5
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS07900
gene id: 760011:SPICO_RS07900
uniprot id: F4GIY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

760011:SPICO RS02535
gene id: 760011:SPICO_RS02535
uniprot id: F4GJ90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

760011:SPICO RS07310
gene id: 760011:SPICO_RS07310
uniprot id: F4GI38
names: Similarity
messages: Belongs to the threonine aldolase family.

760011:SPICO RS06730
gene id: 760011:SPICO_RS06730
uniprot id: F4GM47
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

760011:SPICO RS07110
gene id: 760011:SPICO_RS07110
uniprot id: F4GHK7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

760011:SPICO RS03025
gene id: 760011:SPICO_RS03025
uniprot id: F4GK53
names: Similarity
messages: Belongs to the RibF family.

760011:SPICO RS05055
gene id: 760011:SPICO_RS05055
uniprot id: F4GJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS08920
gene id: 760011:SPICO_RS08920
uniprot id: F4GLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

760011:SPICO RS04710
gene id: 760011:SPICO_RS04710
uniprot id: F4GIK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS03410
gene id: 760011:SPICO_RS03410
uniprot id: F4GKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02570
gene id: 760011:SPICO_RS02570
uniprot id: F4GJ97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

760011:SPICO RS08910
gene id: 760011:SPICO_RS08910
uniprot id: F4GLB4
names: Subcellular Location Annotation
messages: Cytoplasm

760011:SPICO RS00025
gene id: 760011:SPICO_RS00025
uniprot id: F4GI88
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

760011:SPICO RS07690
gene id: 760011:SPICO_RS07690
uniprot id: F4GIU2
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

760011:SPICO RS09085
gene id: 760011:SPICO_RS09085
uniprot id: F4GLT9
names: Similarity
messages: Belongs to the glutamine synthetase family.

760011:SPICO RS01915
gene id: 760011:SPICO_RS01915
uniprot id: F4GHS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS03440
gene id: 760011:SPICO_RS03440
uniprot id: F4GKY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

760011:SPICO RS08740
gene id: 760011:SPICO_RS08740
uniprot id: F4GL82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

760011:SPICO RS03525
gene id: 760011:SPICO_RS03525
uniprot id: F4GLE5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

760011:SPICO RS08850
gene id: 760011:SPICO_RS08850
uniprot id: F4GLA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS01470
gene id: 760011:SPICO_RS01470
uniprot id: F4GH52
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS07500
gene id: 760011:SPICO_RS07500
uniprot id: F4GI76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

760011:SPICO RS06085
gene id: 760011:SPICO_RS06085
uniprot id: F4GL60
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

760011:SPICO RS04060
gene id: 760011:SPICO_RS04060
uniprot id: F4GHB7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

760011:SPICO RS03010
gene id: 760011:SPICO_RS03010
uniprot id: F4GK50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

760011:SPICO RS02390
gene id: 760011:SPICO_RS02390
uniprot id: F4GJ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

760011:SPICO RS01070
gene id: 760011:SPICO_RS01070
uniprot id: F4GKP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

760011:SPICO RS03455
gene id: 760011:SPICO_RS03455
uniprot id: F4GKY8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01430
gene id: 760011:SPICO_RS01430
uniprot id: F4GH45
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

760011:SPICO RS05690
gene id: 760011:SPICO_RS05690
uniprot id: F4GKD3
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

760011:SPICO RS04700
gene id: 760011:SPICO_RS04700
uniprot id: F4GIK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

760011:SPICO RS07970
gene id: 760011:SPICO_RS07970
uniprot id: F4GJL7
names: Similarity
messages: Belongs to the fabD family.

760011:SPICO RS05250
gene id: 760011:SPICO_RS05250
uniprot id: F4GJH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

760011:SPICO RS08765
gene id: 760011:SPICO_RS08765
uniprot id: F4GL87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

760011:SPICO RS06430
gene id: 760011:SPICO_RS06430
uniprot id: F4GLS1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05210
gene id: 760011:SPICO_RS05210
uniprot id: F4GJG9
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

760011:SPICO RS05190
gene id: 760011:SPICO_RS05190
uniprot id: F4GJG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

760011:SPICO RS07875
gene id: 760011:SPICO_RS07875
uniprot id: F4GIX9
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

760011:SPICO RS07620
gene id: 760011:SPICO_RS07620
uniprot id: F4GIS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

760011:SPICO RS05710
gene id: 760011:SPICO_RS05710
uniprot id: F4GKD7
names: Similarity
messages: Belongs to the BMP lipoprotein family.

760011:SPICO RS09695
gene id: 760011:SPICO_RS09695
uniprot id: F4GJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

760011:SPICO RS09415
gene id: 760011:SPICO_RS09415
uniprot id: F4GLZ8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

760011:SPICO RS07125
gene id: 760011:SPICO_RS07125
uniprot id: F4GHL0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

760011:SPICO RS04615
gene id: 760011:SPICO_RS04615
uniprot id: F4GI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS08505
gene id: 760011:SPICO_RS08505
uniprot id: F4GKI3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

760011:SPICO RS06715
gene id: 760011:SPICO_RS06715
uniprot id: F4GM44
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

760011:SPICO RS08995
gene id: 760011:SPICO_RS08995
uniprot id: F4GLD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

760011:SPICO RS01700
gene id: 760011:SPICO_RS01700
uniprot id: F4GHN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

760011:SPICO RS03045
gene id: 760011:SPICO_RS03045
uniprot id: F4GK57
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03655
gene id: 760011:SPICO_RS03655
uniprot id: F4GLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS05000
gene id: 760011:SPICO_RS05000
uniprot id: F4GIR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

760011:SPICO RS07665
gene id: 760011:SPICO_RS07665
uniprot id: F4GIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

760011:SPICO RS00535
gene id: 760011:SPICO_RS00535
uniprot id: F4GJ55
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS06045
gene id: 760011:SPICO_RS06045
uniprot id: F4GL53
names: Similarity
messages: Belongs to the thioredoxin family.

760011:SPICO RS03050
gene id: 760011:SPICO_RS03050
uniprot id: F4GK58
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05015
gene id: 760011:SPICO_RS05015
uniprot id: F4GIR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

760011:SPICO RS02345
gene id: 760011:SPICO_RS02345
uniprot id: F4GII4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

760011:SPICO RS01030
gene id: 760011:SPICO_RS01030
uniprot id: F4GKN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

760011:SPICO RS00460
gene id: 760011:SPICO_RS00460
uniprot id: F4GJ40
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

760011:SPICO RS01570
gene id: 760011:SPICO_RS01570
uniprot id: F4GH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS02700
gene id: 760011:SPICO_RS02700
uniprot id: F4GJC3
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03040
gene id: 760011:SPICO_RS03040
uniprot id: F4GK56
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

760011:SPICO RS08590
gene id: 760011:SPICO_RS08590
uniprot id: F4GKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

760011:SPICO RS00570
gene id: 760011:SPICO_RS00570
uniprot id: F4GJT2
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

760011:SPICO RS02745
gene id: 760011:SPICO_RS02745
uniprot id: F4GJD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

760011:SPICO RS08770
gene id: 760011:SPICO_RS08770
uniprot id: F4GL88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

760011:SPICO RS01500
gene id: 760011:SPICO_RS01500
uniprot id: F4GH58
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01510
gene id: 760011:SPICO_RS01510
uniprot id: F4GH60
names: Similarity
messages: Belongs to the DEAD box helicase family.

760011:SPICO RS05550
gene id: 760011:SPICO_RS05550
uniprot id: F4GKA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01940
gene id: 760011:SPICO_RS01940
uniprot id: F4GHS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

760011:SPICO RS09220
gene id: 760011:SPICO_RS09220
uniprot id: F4GLW5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

760011:SPICO RS02245
gene id: 760011:SPICO_RS02245
uniprot id: F4GIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS03690
gene id: 760011:SPICO_RS03690
uniprot id: F4GLH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS00490
gene id: 760011:SPICO_RS00490
uniprot id: F4GJ46
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03585
gene id: 760011:SPICO_RS03585
uniprot id: F4GLF7
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

760011:SPICO RS03150
gene id: 760011:SPICO_RS03150
uniprot id: F4GKT6
names: Similarity
messages: Belongs to the peptidase M29 family.

760011:SPICO RS06695
gene id: 760011:SPICO_RS06695
uniprot id: F4GM40
names: Similarity
messages: Belongs to the Nudix hydrolase family.

760011:SPICO RS04855
gene id: 760011:SPICO_RS04855
uniprot id: F4GIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS00805
gene id: 760011:SPICO_RS00805
uniprot id: F4GJX5
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02135
gene id: 760011:SPICO_RS02135
uniprot id: F4GIE4
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

760011:SPICO RS05365
gene id: 760011:SPICO_RS05365
uniprot id: F4GJK2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

760011:SPICO RS04540
gene id: 760011:SPICO_RS04540
uniprot id: F4GHZ1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02970
gene id: 760011:SPICO_RS02970
uniprot id: F4GK43
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

760011:SPICO RS08495
gene id: 760011:SPICO_RS08495
uniprot id: F4GKI1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS07605
gene id: 760011:SPICO_RS07605
uniprot id: F4GIS5
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

760011:SPICO RS03760
gene id: 760011:SPICO_RS03760
uniprot id: F4GLJ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

760011:SPICO RS08640
gene id: 760011:SPICO_RS08640
uniprot id: F4GKK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

760011:SPICO RS00565
gene id: 760011:SPICO_RS00565
uniprot id: F4GJT1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS03645
gene id: 760011:SPICO_RS03645
uniprot id: F4GLG9
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

760011:SPICO RS06790
gene id: 760011:SPICO_RS06790
uniprot id: F4GM57
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01230
gene id: 760011:SPICO_RS01230
uniprot id: F4GKS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS05170
gene id: 760011:SPICO_RS05170
uniprot id: F4GJG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

760011:SPICO RS05505
gene id: 760011:SPICO_RS05505
uniprot id: F4GK99
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

760011:SPICO RS03500
gene id: 760011:SPICO_RS03500
uniprot id: F4GKZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

760011:SPICO RS05360
gene id: 760011:SPICO_RS05360
uniprot id: F4GJK1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

760011:SPICO RS05320
gene id: 760011:SPICO_RS05320
uniprot id: F4GJJ3
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS00515
gene id: 760011:SPICO_RS00515
uniprot id: F4GJ51
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

760011:SPICO RS06855
gene id: 760011:SPICO_RS06855
uniprot id: F4GHF6
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08795
gene id: 760011:SPICO_RS08795
uniprot id: F4GL93
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

760011:SPICO RS06635
gene id: 760011:SPICO_RS06635
uniprot id: F4GM29
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

760011:SPICO RS06995
gene id: 760011:SPICO_RS06995
uniprot id: F4GHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02665
gene id: 760011:SPICO_RS02665
uniprot id: F4GJB7
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

760011:SPICO RS03105
gene id: 760011:SPICO_RS03105
uniprot id: F4GK69
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

760011:SPICO RS01065
gene id: 760011:SPICO_RS01065
uniprot id: F4GKP4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS03670
gene id: 760011:SPICO_RS03670
uniprot id: F4GLH4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

760011:SPICO RS00860
gene id: 760011:SPICO_RS00860
uniprot id: F4GJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS08490
gene id: 760011:SPICO_RS08490
uniprot id: F4GKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L-fucose isomerase family.
messages: Converts the aldose L-fucose into the corresponding ketose L-fuculose.
messages: Cytoplasm

760011:SPICO RS08425
gene id: 760011:SPICO_RS08425
uniprot id: F4GKG7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

760011:SPICO RS01400
gene id: 760011:SPICO_RS01400
uniprot id: F4GH39
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS09675
gene id: 760011:SPICO_RS09675
uniprot id: F4GIF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

760011:SPICO RS06005
gene id: 760011:SPICO_RS06005
uniprot id: F4GL46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

760011:SPICO RS03985
gene id: 760011:SPICO_RS03985
uniprot id: F4GHA2
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

760011:SPICO RS03095
gene id: 760011:SPICO_RS03095
uniprot id: F4GK67
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

760011:SPICO RS04025
gene id: 760011:SPICO_RS04025
uniprot id: F4GHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

760011:SPICO RS06740
gene id: 760011:SPICO_RS06740
uniprot id: F4GM49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS08125
gene id: 760011:SPICO_RS08125
uniprot id: F4GJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

760011:SPICO RS01875
gene id: 760011:SPICO_RS01875
uniprot id: F4GHR6
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

760011:SPICO RS03310
gene id: 760011:SPICO_RS03310
uniprot id: F4GKW6
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS07270
gene id: 760011:SPICO_RS07270
uniprot id: F4GI30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS04955
gene id: 760011:SPICO_RS04955
uniprot id: F4GIQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

760011:SPICO RS06815
gene id: 760011:SPICO_RS06815
uniprot id: F4GM62
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

760011:SPICO RS07275
gene id: 760011:SPICO_RS07275
uniprot id: F4GI31
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

760011:SPICO RS06335
gene id: 760011:SPICO_RS06335
uniprot id: F4GLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

760011:SPICO RS09040
gene id: 760011:SPICO_RS09040
uniprot id: F4GLD9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

760011:SPICO RS00700
gene id: 760011:SPICO_RS00700
uniprot id: F4GJV5
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05750
gene id: 760011:SPICO_RS05750
uniprot id: F4GL00
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

760011:SPICO RS08755
gene id: 760011:SPICO_RS08755
uniprot id: F4GL85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

760011:SPICO RS08115
gene id: 760011:SPICO_RS08115
uniprot id: F4GJP5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

760011:SPICO RS05180
gene id: 760011:SPICO_RS05180
uniprot id: F4GJG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS07405
gene id: 760011:SPICO_RS07405
uniprot id: F4GI57
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

760011:SPICO RS08650
gene id: 760011:SPICO_RS08650
uniprot id: F4GKL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

760011:SPICO RS06820
gene id: 760011:SPICO_RS06820
uniprot id: F4GM63
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

760011:SPICO RS05600
gene id: 760011:SPICO_RS05600
uniprot id: F4GKB7
names: Similarity
messages: Belongs to the leucine-binding protein family.

760011:SPICO RS02595
gene id: 760011:SPICO_RS02595
uniprot id: F4GJA2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

760011:SPICO RS07385
gene id: 760011:SPICO_RS07385
uniprot id: F4GI53
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

760011:SPICO RS06280
gene id: 760011:SPICO_RS06280
uniprot id: F4GLP2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

760011:SPICO RS02155
gene id: 760011:SPICO_RS02155
uniprot id: F4GIE8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

760011:SPICO RS01900
gene id: 760011:SPICO_RS01900
uniprot id: F4GHS0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS04100
gene id: 760011:SPICO_RS04100
uniprot id: F4GHC0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

760011:SPICO RS04630
gene id: 760011:SPICO_RS04630
uniprot id: F4GI08
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

760011:SPICO RS08265
gene id: 760011:SPICO_RS08265
uniprot id: F4GJS2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

760011:SPICO RS02445
gene id: 760011:SPICO_RS02445
uniprot id: F4GJ73
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

760011:SPICO RS06700
gene id: 760011:SPICO_RS06700
uniprot id: F4GM41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

760011:SPICO RS01130
gene id: 760011:SPICO_RS01130
uniprot id: F4GKQ3
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

760011:SPICO RS09195
gene id: 760011:SPICO_RS09195
uniprot id: F4GLW0
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

760011:SPICO RS02660
gene id: 760011:SPICO_RS02660
uniprot id: F4GJB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS01120
gene id: 760011:SPICO_RS01120
uniprot id: F4GKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS07260
gene id: 760011:SPICO_RS07260
uniprot id: F4GI28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

760011:SPICO RS08150
gene id: 760011:SPICO_RS08150
uniprot id: F4GJQ2
names: Similarity
messages: Belongs to the disproportionating enzyme family.

760011:SPICO RS04645
gene id: 760011:SPICO_RS04645
uniprot id: F4GI11
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

760011:SPICO RS00450
gene id: 760011:SPICO_RS00450
uniprot id: F4GJ38
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03815
gene id: 760011:SPICO_RS03815
uniprot id: F4GLK2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

760011:SPICO RS09880
gene id: 760011:SPICO_RS09880
uniprot id: F4GM61
names: Similarity
messages: Belongs to the DEAD box helicase family.

760011:SPICO RS03265
gene id: 760011:SPICO_RS03265
uniprot id: F4GKV7
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

760011:SPICO RS03555
gene id: 760011:SPICO_RS03555
uniprot id: F4GLF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS08825
gene id: 760011:SPICO_RS08825
uniprot id: F4GL97
names: Similarity
messages: Belongs to the CarB family.

760011:SPICO RS08470
gene id: 760011:SPICO_RS08470
uniprot id: F4GKH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

760011:SPICO RS08830
gene id: 760011:SPICO_RS08830
uniprot id: F4GL98
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

760011:SPICO RS08695
gene id: 760011:SPICO_RS08695
uniprot id: F4GL73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

760011:SPICO RS07505
gene id: 760011:SPICO_RS07505
uniprot id: F4GI77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

760011:SPICO RS02955
gene id: 760011:SPICO_RS02955
uniprot id: F4GK40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

760011:SPICO RS04665
gene id: 760011:SPICO_RS04665
uniprot id: F4GIJ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

760011:SPICO RS04005
gene id: 760011:SPICO_RS04005
uniprot id: F4GHA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

760011:SPICO RS09175
gene id: 760011:SPICO_RS09175
uniprot id: F4GLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

760011:SPICO RS07120
gene id: 760011:SPICO_RS07120
uniprot id: F4GHK9
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03320
gene id: 760011:SPICO_RS03320
uniprot id: F4GKW8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

760011:SPICO RS04870
gene id: 760011:SPICO_RS04870
uniprot id: F4GIN4
names: Similarity
messages: Belongs to the peptidase S1C family.

760011:SPICO RS02210
gene id: 760011:SPICO_RS02210
uniprot id: F4GIF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

760011:SPICO RS06175
gene id: 760011:SPICO_RS06175
uniprot id: F4GLM3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

760011:SPICO RS08775
gene id: 760011:SPICO_RS08775
uniprot id: F4GL89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

760011:SPICO RS07985
gene id: 760011:SPICO_RS07985
uniprot id: F4GJM0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS00225
gene id: 760011:SPICO_RS00225
uniprot id: F4GIZ3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

760011:SPICO RS08685
gene id: 760011:SPICO_RS08685
uniprot id: F4GL71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

760011:SPICO RS00015
gene id: 760011:SPICO_RS00015
uniprot id: F4GI86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

760011:SPICO RS06425
gene id: 760011:SPICO_RS06425
uniprot id: F4GLS0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

760011:SPICO RS06875
gene id: 760011:SPICO_RS06875
uniprot id: F4GHG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

760011:SPICO RS03995
gene id: 760011:SPICO_RS03995
uniprot id: F4GHA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

760011:SPICO RS03185
gene id: 760011:SPICO_RS03185
uniprot id: F4GKU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

760011:SPICO RS04820
gene id: 760011:SPICO_RS04820
uniprot id: F4GIM4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

760011:SPICO RS03685
gene id: 760011:SPICO_RS03685
uniprot id: F4GLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS05760
gene id: 760011:SPICO_RS05760
uniprot id: F4GL02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

760011:SPICO RS06055
gene id: 760011:SPICO_RS06055
uniprot id: F4GL55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

760011:SPICO RS02800
gene id: 760011:SPICO_RS02800
uniprot id: F4GK10
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

760011:SPICO RS01710
gene id: 760011:SPICO_RS01710
uniprot id: F4GHN6
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

760011:SPICO RS00185
gene id: 760011:SPICO_RS00185
uniprot id: F4GIY4
names: Similarity
messages: Belongs to the thymidine kinase family.

760011:SPICO RS09350
gene id: 760011:SPICO_RS09350
uniprot id: F4GLZ0
names: Similarity
messages: Belongs to the peptidase M24B family.

760011:SPICO RS04775
gene id: 760011:SPICO_RS04775
uniprot id: F4GIL5
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

760011:SPICO RS04010
gene id: 760011:SPICO_RS04010
uniprot id: F4GHA7
names: Similarity
messages: Belongs to the type IA topoisomerase family.

760011:SPICO RS02925
gene id: 760011:SPICO_RS02925
uniprot id: F4GK34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

760011:SPICO RS07220
gene id: 760011:SPICO_RS07220
uniprot id: F4GI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS10290
gene id: 760011:SPICO_RS10290
uniprot id: F4GLP4
names: Similarity
messages: Belongs to the AOR/FOR family.

760011:SPICO RS00495
gene id: 760011:SPICO_RS00495
uniprot id: F4GJ47
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03715
gene id: 760011:SPICO_RS03715
uniprot id: F4GLI3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

760011:SPICO RS04020
gene id: 760011:SPICO_RS04020
uniprot id: F4GHA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

760011:SPICO RS00320
gene id: 760011:SPICO_RS00320
uniprot id: F4GJ12
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02965
gene id: 760011:SPICO_RS02965
uniprot id: F4GK42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

760011:SPICO RS07070
gene id: 760011:SPICO_RS07070
uniprot id: F4GHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS06330
gene id: 760011:SPICO_RS06330
uniprot id: F4GLQ2
names: Similarity
messages: Belongs to the CinA family.

760011:SPICO RS07160
gene id: 760011:SPICO_RS07160
uniprot id: F4GHL7
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01640
gene id: 760011:SPICO_RS01640
uniprot id: F4GHM2
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS09355
gene id: 760011:SPICO_RS09355
uniprot id: F4GLZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

760011:SPICO RS09325
gene id: 760011:SPICO_RS09325
uniprot id: F4GLY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

760011:SPICO RS09285
gene id: 760011:SPICO_RS09285
uniprot id: F4GLX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

760011:SPICO RS01855
gene id: 760011:SPICO_RS01855
uniprot id: F4GHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

760011:SPICO RS02350
gene id: 760011:SPICO_RS02350
uniprot id: F4GII5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

760011:SPICO RS05565
gene id: 760011:SPICO_RS05565
uniprot id: F4GKB0
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

760011:SPICO RS08675
gene id: 760011:SPICO_RS08675
uniprot id: F4GL68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

760011:SPICO RS00120
gene id: 760011:SPICO_RS00120
uniprot id: F4GIA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

760011:SPICO RS07265
gene id: 760011:SPICO_RS07265
uniprot id: F4GI29
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

760011:SPICO RS08720
gene id: 760011:SPICO_RS08720
uniprot id: F4GL78
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

760011:SPICO RS01495
gene id: 760011:SPICO_RS01495
uniprot id: F4GH57
names: Similarity
messages: Belongs to the TrpR family.

760011:SPICO RS06340
gene id: 760011:SPICO_RS06340
uniprot id: F4GLQ4
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

760011:SPICO RS09705
gene id: 760011:SPICO_RS09705
uniprot id: F4GKV2
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS04985
gene id: 760011:SPICO_RS04985
uniprot id: F4GIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

760011:SPICO RS03450
gene id: 760011:SPICO_RS03450
uniprot id: F4GKY7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

760011:SPICO RS01055
gene id: 760011:SPICO_RS01055
uniprot id: F4GKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

760011:SPICO RS03615
gene id: 760011:SPICO_RS03615
uniprot id: F4GLG3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

760011:SPICO RS05065
gene id: 760011:SPICO_RS05065
uniprot id: F4GJE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS07990
gene id: 760011:SPICO_RS07990
uniprot id: F4GJM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

760011:SPICO RS02725
gene id: 760011:SPICO_RS02725
uniprot id: F4GJC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

760011:SPICO RS08855
gene id: 760011:SPICO_RS08855
uniprot id: F4GLA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02560
gene id: 760011:SPICO_RS02560
uniprot id: F4GJ95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

760011:SPICO RS04840
gene id: 760011:SPICO_RS04840
uniprot id: F4GIM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS09240
gene id: 760011:SPICO_RS09240
uniprot id: F4GLW9
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08060
gene id: 760011:SPICO_RS08060
uniprot id: F4GJN5
names: Similarity
messages: Belongs to the leucine-binding protein family.

760011:SPICO RS05195
gene id: 760011:SPICO_RS05195
uniprot id: F4GJG6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

760011:SPICO RS03250
gene id: 760011:SPICO_RS03250
uniprot id: F4GKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

760011:SPICO RS03215
gene id: 760011:SPICO_RS03215
uniprot id: F4GKU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

760011:SPICO RS04725
gene id: 760011:SPICO_RS04725
uniprot id: F4GIK6
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

760011:SPICO RS03900
gene id: 760011:SPICO_RS03900
uniprot id: F4GH86
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

760011:SPICO RS04810
gene id: 760011:SPICO_RS04810
uniprot id: F4GIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

760011:SPICO RS03470
gene id: 760011:SPICO_RS03470
uniprot id: F4GKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

760011:SPICO RS03365
gene id: 760011:SPICO_RS03365
uniprot id: F4GKX7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

760011:SPICO RS01590
gene id: 760011:SPICO_RS01590
uniprot id: F4GH75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

760011:SPICO RS06455
gene id: 760011:SPICO_RS06455
uniprot id: F4GLS6
names: Similarity
messages: Belongs to the xylose isomerase family.

760011:SPICO RS07825
gene id: 760011:SPICO_RS07825
uniprot id: F4GIW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS01395
gene id: 760011:SPICO_RS01395
uniprot id: F4GH38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS08790
gene id: 760011:SPICO_RS08790
uniprot id: F4GL92
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

760011:SPICO RS09130
gene id: 760011:SPICO_RS09130
uniprot id: F4GLU7
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

760011:SPICO RS04035
gene id: 760011:SPICO_RS04035
uniprot id: F4GHB2
names: Similarity
messages: Belongs to the peptidase M29 family.

760011:SPICO RS09745
gene id: 760011:SPICO_RS09745
uniprot id: F4GIR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

760011:SPICO RS04350
gene id: 760011:SPICO_RS04350
uniprot id: F4GHV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

760011:SPICO RS01800
gene id: 760011:SPICO_RS01800
uniprot id: F4GHQ2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

760011:SPICO RS00690
gene id: 760011:SPICO_RS00690
uniprot id: F4GJV3
names: Similarity
messages: Belongs to the PspA/IM30 family.

760011:SPICO RS04525
gene id: 760011:SPICO_RS04525
uniprot id: F4GHY8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

760011:SPICO RS03390
gene id: 760011:SPICO_RS03390
uniprot id: F4GKX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

760011:SPICO RS04995
gene id: 760011:SPICO_RS04995
uniprot id: F4GIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

760011:SPICO RS04935
gene id: 760011:SPICO_RS04935
uniprot id: F4GIP7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

760011:SPICO RS04790
gene id: 760011:SPICO_RS04790
uniprot id: F4GIL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

760011:SPICO RS09100
gene id: 760011:SPICO_RS09100
uniprot id: F4GLU1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS07795
gene id: 760011:SPICO_RS07795
uniprot id: F4GIW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS02945
gene id: 760011:SPICO_RS02945
uniprot id: F4GK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

760011:SPICO RS01960
gene id: 760011:SPICO_RS01960
uniprot id: F4GHT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

760011:SPICO RS09460
gene id: 760011:SPICO_RS09460
uniprot id: F4GM72
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

760011:SPICO RS03275
gene id: 760011:SPICO_RS03275
uniprot id: F4GKV9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

760011:SPICO RS06650
gene id: 760011:SPICO_RS06650
uniprot id: F4GM32
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

760011:SPICO RS07950
gene id: 760011:SPICO_RS07950
uniprot id: F4GJL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
messages: Monomer.

760011:SPICO RS06265
gene id: 760011:SPICO_RS06265
uniprot id: F4GLN9
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05185
gene id: 760011:SPICO_RS05185
uniprot id: F4GJG4
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

760011:SPICO RS00810
gene id: 760011:SPICO_RS00810
uniprot id: F4GJX6
names: Similarity
messages: Belongs to the UPF0111 family.

760011:SPICO RS07695
gene id: 760011:SPICO_RS07695
uniprot id: F4GIU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

760011:SPICO RS07510
gene id: 760011:SPICO_RS07510
uniprot id: F4GI78
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

760011:SPICO RS07305
gene id: 760011:SPICO_RS07305
uniprot id: F4GI37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

760011:SPICO RS08430
gene id: 760011:SPICO_RS08430
uniprot id: F4GKG8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

760011:SPICO RS01075
gene id: 760011:SPICO_RS01075
uniprot id: F4GKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

760011:SPICO RS02695
gene id: 760011:SPICO_RS02695
uniprot id: F4GJC2
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01600
gene id: 760011:SPICO_RS01600
uniprot id: F4GH77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

760011:SPICO RS06555
gene id: 760011:SPICO_RS06555
uniprot id: F4GM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS03795
gene id: 760011:SPICO_RS03795
uniprot id: F4GLJ8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

760011:SPICO RS07400
gene id: 760011:SPICO_RS07400
uniprot id: F4GI56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

760011:SPICO RS09915
gene id: 760011:SPICO_RS09915
uniprot id: F4GI43
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

760011:SPICO RS04380
gene id: 760011:SPICO_RS04380
uniprot id: F4GHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02270
gene id: 760011:SPICO_RS02270
uniprot id: F4GIG9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

760011:SPICO RS09030
gene id: 760011:SPICO_RS09030
uniprot id: F4GLD7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

760011:SPICO RS00035
gene id: 760011:SPICO_RS00035
uniprot id: F4GI90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

760011:SPICO RS00775
gene id: 760011:SPICO_RS00775
uniprot id: F4GJW9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

760011:SPICO RS00390
gene id: 760011:SPICO_RS00390
uniprot id: F4GJ26
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS09280
gene id: 760011:SPICO_RS09280
uniprot id: F4GLX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

760011:SPICO RS06240
gene id: 760011:SPICO_RS06240
uniprot id: F4GLN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

760011:SPICO RS07555
gene id: 760011:SPICO_RS07555
uniprot id: F4GIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS02385
gene id: 760011:SPICO_RS02385
uniprot id: F4GJ60
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

760011:SPICO RS00770
gene id: 760011:SPICO_RS00770
uniprot id: F4GJW8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

760011:SPICO RS01985
gene id: 760011:SPICO_RS01985
uniprot id: F4GHT7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

760011:SPICO RS00230
gene id: 760011:SPICO_RS00230
uniprot id: F4GIZ4
names: Similarity
messages: Belongs to the UxaA family.

760011:SPICO RS01605
gene id: 760011:SPICO_RS01605
uniprot id: F4GH78
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

760011:SPICO RS09185
gene id: 760011:SPICO_RS09185
uniprot id: F4GLV8
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

760011:SPICO RS03100
gene id: 760011:SPICO_RS03100
uniprot id: F4GK68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

760011:SPICO RS02300
gene id: 760011:SPICO_RS02300
uniprot id: F4GIH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

760011:SPICO RS02985
gene id: 760011:SPICO_RS02985
uniprot id: F4GK46
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

760011:SPICO RS08235
gene id: 760011:SPICO_RS08235
uniprot id: F4GJR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

760011:SPICO RS01620
gene id: 760011:SPICO_RS01620
uniprot id: F4GH81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS00680
gene id: 760011:SPICO_RS00680
uniprot id: F4GJV1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS06270
gene id: 760011:SPICO_RS06270
uniprot id: F4GLP0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08450
gene id: 760011:SPICO_RS08450
uniprot id: F4GKH2
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02790
gene id: 760011:SPICO_RS02790
uniprot id: F4GK08
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

760011:SPICO RS03905
gene id: 760011:SPICO_RS03905
uniprot id: F4GH87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

760011:SPICO RS05040
gene id: 760011:SPICO_RS05040
uniprot id: F4GJD6
names: Subcellular Location Annotation
messages: Nucleus

760011:SPICO RS03360
gene id: 760011:SPICO_RS03360
uniprot id: F4GKX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS03295
gene id: 760011:SPICO_RS03295
uniprot id: F4GKW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

760011:SPICO RS04425
gene id: 760011:SPICO_RS04425
uniprot id: F4GHW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

760011:SPICO RS07215
gene id: 760011:SPICO_RS07215
uniprot id: F4GI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS07190
gene id: 760011:SPICO_RS07190
uniprot id: F4GI14
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

760011:SPICO RS03920
gene id: 760011:SPICO_RS03920
uniprot id: F4GH90
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

760011:SPICO RS04445
gene id: 760011:SPICO_RS04445
uniprot id: F4GHX3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

760011:SPICO RS00305
gene id: 760011:SPICO_RS00305
uniprot id: F4GJ09
names: Similarity
messages: Belongs to the BMP lipoprotein family.

760011:SPICO RS03300
gene id: 760011:SPICO_RS03300
uniprot id: F4GKW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

760011:SPICO RS02545
gene id: 760011:SPICO_RS02545
uniprot id: F4GJ92
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

760011:SPICO RS04000
gene id: 760011:SPICO_RS04000
uniprot id: F4GHA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

760011:SPICO RS08555
gene id: 760011:SPICO_RS08555
uniprot id: F4GKJ3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

760011:SPICO RS02415
gene id: 760011:SPICO_RS02415
uniprot id: F4GJ67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

760011:SPICO RS08055
gene id: 760011:SPICO_RS08055
uniprot id: F4GJN4
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS10000
gene id: 760011:SPICO_RS10000
uniprot id: F4GLZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

760011:SPICO RS01630
gene id: 760011:SPICO_RS01630
uniprot id: F4GH83
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

760011:SPICO RS05455
gene id: 760011:SPICO_RS05455
uniprot id: F4GK89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

760011:SPICO RS05695
gene id: 760011:SPICO_RS05695
uniprot id: F4GKD4
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05315
gene id: 760011:SPICO_RS05315
uniprot id: F4GJJ2
names: Similarity
messages: Belongs to the UPF0047 family.

760011:SPICO RS06235
gene id: 760011:SPICO_RS06235
uniprot id: F4GLN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

760011:SPICO RS08635
gene id: 760011:SPICO_RS08635
uniprot id: F4GKK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

760011:SPICO RS08050
gene id: 760011:SPICO_RS08050
uniprot id: F4GJN3
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01375
gene id: 760011:SPICO_RS01375
uniprot id: F4GH35
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

760011:SPICO RS06550
gene id: 760011:SPICO_RS06550
uniprot id: F4GM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS06230
gene id: 760011:SPICO_RS06230
uniprot id: F4GLN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

760011:SPICO RS03730
gene id: 760011:SPICO_RS03730
uniprot id: F4GLI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

760011:SPICO RS03130
gene id: 760011:SPICO_RS03130
uniprot id: F4GKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

760011:SPICO RS08240
gene id: 760011:SPICO_RS08240
uniprot id: F4GJR8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

760011:SPICO RS03505
gene id: 760011:SPICO_RS03505
uniprot id: F4GKZ8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

760011:SPICO RS06595
gene id: 760011:SPICO_RS06595
uniprot id: F4GM21
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

760011:SPICO RS06600
gene id: 760011:SPICO_RS06600
uniprot id: F4GM22
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

760011:SPICO RS08990
gene id: 760011:SPICO_RS08990
uniprot id: F4GLD0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

760011:SPICO RS03945
gene id: 760011:SPICO_RS03945
uniprot id: F4GH94
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

760011:SPICO RS05420
gene id: 760011:SPICO_RS05420
uniprot id: F4GK82
names: Cofactor
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

760011:SPICO RS02795
gene id: 760011:SPICO_RS02795
uniprot id: F4GK09
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

760011:SPICO RS05060
gene id: 760011:SPICO_RS05060
uniprot id: F4GJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS00715
gene id: 760011:SPICO_RS00715
uniprot id: F4GJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

760011:SPICO RS05915
gene id: 760011:SPICO_RS05915
uniprot id: F4GL30
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

760011:SPICO RS02540
gene id: 760011:SPICO_RS02540
uniprot id: F4GJ91
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

760011:SPICO RS02295
gene id: 760011:SPICO_RS02295
uniprot id: F4GIH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

760011:SPICO RS03825
gene id: 760011:SPICO_RS03825
uniprot id: F4GLK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS08665
gene id: 760011:SPICO_RS08665
uniprot id: F4GKL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

760011:SPICO RS08660
gene id: 760011:SPICO_RS08660
uniprot id: F4GKL4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

760011:SPICO RS08620
gene id: 760011:SPICO_RS08620
uniprot id: F4GKK5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

760011:SPICO RS03895
gene id: 760011:SPICO_RS03895
uniprot id: F4GH85
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

760011:SPICO RS08630
gene id: 760011:SPICO_RS08630
uniprot id: F4GKK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

760011:SPICO RS04375
gene id: 760011:SPICO_RS04375
uniprot id: F4GHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS06860
gene id: 760011:SPICO_RS06860
uniprot id: F4GHF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

760011:SPICO RS07285
gene id: 760011:SPICO_RS07285
uniprot id: F4GI33
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

760011:SPICO RS08135
gene id: 760011:SPICO_RS08135
uniprot id: F4GJP9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS02010
gene id: 760011:SPICO_RS02010
uniprot id: F4GIC2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

760011:SPICO RS04910
gene id: 760011:SPICO_RS04910
uniprot id: F4GIP2
names: Similarity
messages: Belongs to the Fur family.

760011:SPICO RS06310
gene id: 760011:SPICO_RS06310
uniprot id: F4GLP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

760011:SPICO RS06395
gene id: 760011:SPICO_RS06395
uniprot id: F4GLR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

760011:SPICO RS05765
gene id: 760011:SPICO_RS05765
uniprot id: F4GL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

760011:SPICO RS00125
gene id: 760011:SPICO_RS00125
uniprot id: F4GIA8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

760011:SPICO RS08305
gene id: 760011:SPICO_RS08305
uniprot id: F4GKE4
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08785
gene id: 760011:SPICO_RS08785
uniprot id: F4GL91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

760011:SPICO RS07200
gene id: 760011:SPICO_RS07200
uniprot id: F4GI16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

760011:SPICO RS07975
gene id: 760011:SPICO_RS07975
uniprot id: F4GJL8
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

760011:SPICO RS04410
gene id: 760011:SPICO_RS04410
uniprot id: F4GHW6
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

760011:SPICO RS03480
gene id: 760011:SPICO_RS03480
uniprot id: F4GKZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

760011:SPICO RS03560
gene id: 760011:SPICO_RS03560
uniprot id: F4GLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

760011:SPICO RS01125
gene id: 760011:SPICO_RS01125
uniprot id: F4GKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

760011:SPICO RS03000
gene id: 760011:SPICO_RS03000
uniprot id: F4GK48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

760011:SPICO RS07945
gene id: 760011:SPICO_RS07945
uniprot id: F4GJL2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS08725
gene id: 760011:SPICO_RS08725
uniprot id: F4GL79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

760011:SPICO RS06880
gene id: 760011:SPICO_RS06880
uniprot id: F4GHG1
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

760011:SPICO RS01690
gene id: 760011:SPICO_RS01690
uniprot id: F4GHN2
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

760011:SPICO RS09165
gene id: 760011:SPICO_RS09165
uniprot id: F4GLV4
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

760011:SPICO RS03005
gene id: 760011:SPICO_RS03005
uniprot id: F4GK49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

760011:SPICO RS05280
gene id: 760011:SPICO_RS05280
uniprot id: F4GJI5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS08760
gene id: 760011:SPICO_RS08760
uniprot id: F4GL86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

760011:SPICO RS08705
gene id: 760011:SPICO_RS08705
uniprot id: F4GL75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

760011:SPICO RS00455
gene id: 760011:SPICO_RS00455
uniprot id: F4GJ39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

760011:SPICO RS04575
gene id: 760011:SPICO_RS04575
uniprot id: F4GHZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS06125
gene id: 760011:SPICO_RS06125
uniprot id: F4GLL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

760011:SPICO RS03495
gene id: 760011:SPICO_RS03495
uniprot id: F4GKZ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

760011:SPICO RS01410
gene id: 760011:SPICO_RS01410
uniprot id: F4GH41
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

760011:SPICO RS07240
gene id: 760011:SPICO_RS07240
uniprot id: F4GI24
names: Similarity
messages: Belongs to the UPF0758 family.

760011:SPICO RS03885
gene id: 760011:SPICO_RS03885
uniprot id: F4GLL2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

760011:SPICO RS01880
gene id: 760011:SPICO_RS01880
uniprot id: F4GHR7
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS09120
gene id: 760011:SPICO_RS09120
uniprot id: F4GLU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS01190
gene id: 760011:SPICO_RS01190
uniprot id: F4GKR5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

760011:SPICO RS08010
gene id: 760011:SPICO_RS08010
uniprot id: F4GJM5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

760011:SPICO RS05615
gene id: 760011:SPICO_RS05615
uniprot id: F4GKB9
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

760011:SPICO RS05030
gene id: 760011:SPICO_RS05030
uniprot id: F4GJD4
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

760011:SPICO RS07185
gene id: 760011:SPICO_RS07185
uniprot id: F4GI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS04515
gene id: 760011:SPICO_RS04515
uniprot id: F4GHY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

760011:SPICO RS08165
gene id: 760011:SPICO_RS08165
uniprot id: F4GJQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS02435
gene id: 760011:SPICO_RS02435
uniprot id: F4GJ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

760011:SPICO RS01945
gene id: 760011:SPICO_RS01945
uniprot id: F4GHS9
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

760011:SPICO RS09160
gene id: 760011:SPICO_RS09160
uniprot id: F4GLV3
names: Similarity
messages: Belongs to the YggT family.

760011:SPICO RS07415
gene id: 760011:SPICO_RS07415
uniprot id: F4GI59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

760011:SPICO RS06845
gene id: 760011:SPICO_RS06845
uniprot id: F4GHF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

760011:SPICO RS02610
gene id: 760011:SPICO_RS02610
uniprot id: F4GJA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

760011:SPICO RS06955
gene id: 760011:SPICO_RS06955
uniprot id: F4GHH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

760011:SPICO RS01905
gene id: 760011:SPICO_RS01905
uniprot id: F4GHS1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

760011:SPICO RS08780
gene id: 760011:SPICO_RS08780
uniprot id: F4GL90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

760011:SPICO RS05625
gene id: 760011:SPICO_RS05625
uniprot id: F4GKC1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

760011:SPICO RS02600
gene id: 760011:SPICO_RS02600
uniprot id: F4GJA3
names: Similarity
messages: Belongs to the UPF0102 family.

760011:SPICO RS07145
gene id: 760011:SPICO_RS07145
uniprot id: F4GHL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

760011:SPICO RS01280
gene id: 760011:SPICO_RS01280
uniprot id: F4GH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS09050
gene id: 760011:SPICO_RS09050
uniprot id: F4GLE1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

760011:SPICO RS06320
gene id: 760011:SPICO_RS06320
uniprot id: F4GLQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

760011:SPICO RS01680
gene id: 760011:SPICO_RS01680
uniprot id: F4GHN0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03425
gene id: 760011:SPICO_RS03425
uniprot id: F4GKY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

760011:SPICO RS03775
gene id: 760011:SPICO_RS03775
uniprot id: F4GLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS01105
gene id: 760011:SPICO_RS01105
uniprot id: F4GKP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS09205
gene id: 760011:SPICO_RS09205
uniprot id: F4GLW2
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

760011:SPICO RS02165
gene id: 760011:SPICO_RS02165
uniprot id: F4GIF0
names: Similarity
messages: Belongs to the threonine synthase family.

760011:SPICO RS09795
gene id: 760011:SPICO_RS09795
uniprot id: F4GKE0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

760011:SPICO RS04715
gene id: 760011:SPICO_RS04715
uniprot id: F4GIK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

760011:SPICO RS02315
gene id: 760011:SPICO_RS02315
uniprot id: F4GIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

760011:SPICO RS01740
gene id: 760011:SPICO_RS01740
uniprot id: F4GHP2
names: Cofactor
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN covalently per subunit.

760011:SPICO RS06560
gene id: 760011:SPICO_RS06560
uniprot id: F4GM15
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

760011:SPICO RS06070
gene id: 760011:SPICO_RS06070
uniprot id: F4GL58
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

760011:SPICO RS08745
gene id: 760011:SPICO_RS08745
uniprot id: F4GL83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

760011:SPICO RS08810
gene id: 760011:SPICO_RS08810
uniprot id: F4GL95
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

760011:SPICO RS09020
gene id: 760011:SPICO_RS09020
uniprot id: F4GLD5
names: Similarity
messages: Belongs to the asparagine synthetase family.

760011:SPICO RS08800
gene id: 760011:SPICO_RS08800
uniprot id: F4GL94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

760011:SPICO RS04475
gene id: 760011:SPICO_RS04475
uniprot id: F4GHX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS01580
gene id: 760011:SPICO_RS01580
uniprot id: F4GH73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

760011:SPICO RS07670
gene id: 760011:SPICO_RS07670
uniprot id: F4GIT8
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

760011:SPICO RS02940
gene id: 760011:SPICO_RS02940
uniprot id: F4GK37
names: Similarity
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.

760011:SPICO RS06930
gene id: 760011:SPICO_RS06930
uniprot id: F4GHH1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05515
gene id: 760011:SPICO_RS05515
uniprot id: F4GKA1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

760011:SPICO RS06135
gene id: 760011:SPICO_RS06135
uniprot id: F4GLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS09935
gene id: 760011:SPICO_RS09935
uniprot id: F4GIR7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

760011:SPICO RS09080
gene id: 760011:SPICO_RS09080
uniprot id: F4GLT8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

760011:SPICO RS07075
gene id: 760011:SPICO_RS07075
uniprot id: F4GHK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS08560
gene id: 760011:SPICO_RS08560
uniprot id: F4GKJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

760011:SPICO RS00200
gene id: 760011:SPICO_RS00200
uniprot id: F4GIY8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

760011:SPICO RS03070
gene id: 760011:SPICO_RS03070
uniprot id: F4GK62
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

760011:SPICO RS02115
gene id: 760011:SPICO_RS02115
uniprot id: F4GIE1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

760011:SPICO RS00560
gene id: 760011:SPICO_RS00560
uniprot id: F4GJT0
names: Similarity
messages: Belongs to the UPF0597 family.

760011:SPICO RS02495
gene id: 760011:SPICO_RS02495
uniprot id: F4GJ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS01595
gene id: 760011:SPICO_RS01595
uniprot id: F4GH76
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS00785
gene id: 760011:SPICO_RS00785
uniprot id: F4GJX1
names: Similarity
messages: Belongs to the alkaline phosphatase family.

760011:SPICO RS04095
gene id: 760011:SPICO_RS04095
uniprot id: F4GHB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

760011:SPICO RS03610
gene id: 760011:SPICO_RS03610
uniprot id: F4GLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

760011:SPICO RS00815
gene id: 760011:SPICO_RS00815
uniprot id: F4GJX7
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS07625
gene id: 760011:SPICO_RS07625
uniprot id: F4GIS8
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01925
gene id: 760011:SPICO_RS01925
uniprot id: F4GHS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

760011:SPICO RS07855
gene id: 760011:SPICO_RS07855
uniprot id: F4GIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS03875
gene id: 760011:SPICO_RS03875
uniprot id: F4GLL0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

760011:SPICO RS00195
gene id: 760011:SPICO_RS00195
uniprot id: F4GIY6
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

760011:SPICO RS06975
gene id: 760011:SPICO_RS06975
uniprot id: F4GHI0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

760011:SPICO RS00155
gene id: 760011:SPICO_RS00155
uniprot id: F4GIB4
names: Similarity
messages: Belongs to the IMPACT family.

760011:SPICO RS05810
gene id: 760011:SPICO_RS05810
uniprot id: F4GL12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

760011:SPICO RS09010
gene id: 760011:SPICO_RS09010
uniprot id: F4GLD4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

760011:SPICO RS04750
gene id: 760011:SPICO_RS04750
uniprot id: F4GIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

760011:SPICO RS03155
gene id: 760011:SPICO_RS03155
uniprot id: F4GKT7
names: Similarity
messages: Belongs to the peptidase M29 family.

760011:SPICO RS03820
gene id: 760011:SPICO_RS03820
uniprot id: F4GLK3
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

760011:SPICO RS09395
gene id: 760011:SPICO_RS09395
uniprot id: F4GLZ4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

760011:SPICO RS01340
gene id: 760011:SPICO_RS01340
uniprot id: F4GH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS06905
gene id: 760011:SPICO_RS06905
uniprot id: F4GHG6
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

760011:SPICO RS03020
gene id: 760011:SPICO_RS03020
uniprot id: F4GK52
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

760011:SPICO RS05520
gene id: 760011:SPICO_RS05520
uniprot id: F4GKA2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

760011:SPICO RS01920
gene id: 760011:SPICO_RS01920
uniprot id: F4GHS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS04825
gene id: 760011:SPICO_RS04825
uniprot id: F4GIM5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

760011:SPICO RS00030
gene id: 760011:SPICO_RS00030
uniprot id: F4GI89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

760011:SPICO RS06915
gene id: 760011:SPICO_RS06915
uniprot id: F4GHG8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

760011:SPICO RS07360
gene id: 760011:SPICO_RS07360
uniprot id: F4GI48
names: Similarity
messages: Belongs to the class-I fumarase family.

760011:SPICO RS04745
gene id: 760011:SPICO_RS04745
uniprot id: F4GIL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

760011:SPICO RS08410
gene id: 760011:SPICO_RS08410
uniprot id: F4GKG4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

760011:SPICO RS00080
gene id: 760011:SPICO_RS00080
uniprot id: F4GI99
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02090
gene id: 760011:SPICO_RS02090
uniprot id: F4GID6
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS04695
gene id: 760011:SPICO_RS04695
uniprot id: F4GIK0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01865
gene id: 760011:SPICO_RS01865
uniprot id: F4GHR4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

760011:SPICO RS02030
gene id: 760011:SPICO_RS02030
uniprot id: F4GIC6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

760011:SPICO RS08105
gene id: 760011:SPICO_RS08105
uniprot id: F4GJP3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

760011:SPICO RS00800
gene id: 760011:SPICO_RS00800
uniprot id: F4GJX4
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02555
gene id: 760011:SPICO_RS02555
uniprot id: F4GJ94
names: Subcellular Location Annotation
messages: Nucleus

760011:SPICO RS04830
gene id: 760011:SPICO_RS04830
uniprot id: F4GIM6
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

760011:SPICO RS08140
gene id: 760011:SPICO_RS08140
uniprot id: F4GJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

760011:SPICO RS08550
gene id: 760011:SPICO_RS08550
uniprot id: F4GKJ2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

760011:SPICO RS00415
gene id: 760011:SPICO_RS00415
uniprot id: F4GJ31
names: Similarity
messages: Belongs to the TPP enzyme family.

760011:SPICO RS08195
gene id: 760011:SPICO_RS08195
uniprot id: F4GJR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

760011:SPICO RS09515
gene id: 760011:SPICO_RS09515
uniprot id: F4GM83
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

760011:SPICO RS03135
gene id: 760011:SPICO_RS03135
uniprot id: F4GKT4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

760011:SPICO RS05720
gene id: 760011:SPICO_RS05720
uniprot id: F4GKD9
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03335
gene id: 760011:SPICO_RS03335
uniprot id: F4GKX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

760011:SPICO RS03315
gene id: 760011:SPICO_RS03315
uniprot id: F4GKW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

760011:SPICO RS00325
gene id: 760011:SPICO_RS00325
uniprot id: F4GJ13
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

760011:SPICO RS03290
gene id: 760011:SPICO_RS03290
uniprot id: F4GKW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

760011:SPICO RS04050
gene id: 760011:SPICO_RS04050
uniprot id: F4GHB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

760011:SPICO RS05370
gene id: 760011:SPICO_RS05370
uniprot id: F4GJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS00135
gene id: 760011:SPICO_RS00135
uniprot id: F4GIB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01735
gene id: 760011:SPICO_RS01735
uniprot id: F4GHP1
names: Similarity
messages: Belongs to the pyruvate kinase family.

760011:SPICO RS07550
gene id: 760011:SPICO_RS07550
uniprot id: F4GIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

760011:SPICO RS07915
gene id: 760011:SPICO_RS07915
uniprot id: F4GJK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

760011:SPICO RS04785
gene id: 760011:SPICO_RS04785
uniprot id: F4GIL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

760011:SPICO RS05415
gene id: 760011:SPICO_RS05415
uniprot id: F4GK81
names: Similarity
messages: Belongs to the UMP kinase family.

760011:SPICO RS01615
gene id: 760011:SPICO_RS01615
uniprot id: F4GH80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

760011:SPICO RS04090
gene id: 760011:SPICO_RS04090
uniprot id: F4GHB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

760011:SPICO RS07820
gene id: 760011:SPICO_RS07820
uniprot id: F4GIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS05660
gene id: 760011:SPICO_RS05660
uniprot id: F4GKC8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

760011:SPICO RS06250
gene id: 760011:SPICO_RS06250
uniprot id: F4GLN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS03075
gene id: 760011:SPICO_RS03075
uniprot id: F4GK63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

760011:SPICO RS05740
gene id: 760011:SPICO_RS05740
uniprot id: F4GKE3
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

760011:SPICO RS01275
gene id: 760011:SPICO_RS01275
uniprot id: F4GKT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS00430
gene id: 760011:SPICO_RS00430
uniprot id: F4GJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm

760011:SPICO RS02370
gene id: 760011:SPICO_RS02370
uniprot id: F4GII9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

760011:SPICO RS07050
gene id: 760011:SPICO_RS07050
uniprot id: F4GHJ5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

760011:SPICO RS03565
gene id: 760011:SPICO_RS03565
uniprot id: F4GLF3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

760011:SPICO RS04585
gene id: 760011:SPICO_RS04585
uniprot id: F4GHZ9
names: Similarity
messages: Belongs to the UPF0178 family.

760011:SPICO RS09105
gene id: 760011:SPICO_RS09105
uniprot id: F4GLU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

760011:SPICO RS05650
gene id: 760011:SPICO_RS05650
uniprot id: F4GKC6
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03060
gene id: 760011:SPICO_RS03060
uniprot id: F4GK60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

760011:SPICO RS09045
gene id: 760011:SPICO_RS09045
uniprot id: F4GLE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

760011:SPICO RS05125
gene id: 760011:SPICO_RS05125
uniprot id: F4GJF2
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03245
gene id: 760011:SPICO_RS03245
uniprot id: F4GKV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01310
gene id: 760011:SPICO_RS01310
uniprot id: F4GH23
names: Similarity
messages: Belongs to the aspartokinase family.

760011:SPICO RS08380
gene id: 760011:SPICO_RS08380
uniprot id: F4GKF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS02590
gene id: 760011:SPICO_RS02590
uniprot id: F4GJA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

760011:SPICO RS07720
gene id: 760011:SPICO_RS07720
uniprot id: F4GIU8
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS01155
gene id: 760011:SPICO_RS01155
uniprot id: F4GKQ7
names: Similarity
messages: Belongs to the Dps family.

760011:SPICO RS03635
gene id: 760011:SPICO_RS03635
uniprot id: F4GLG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

760011:SPICO RS09750
gene id: 760011:SPICO_RS09750
uniprot id: F4GJD5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

760011:SPICO RS02380
gene id: 760011:SPICO_RS02380
uniprot id: F4GIJ1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

760011:SPICO RS04590
gene id: 760011:SPICO_RS04590
uniprot id: F4GI00
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

760011:SPICO RS06030
gene id: 760011:SPICO_RS06030
uniprot id: F4GL50
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS05230
gene id: 760011:SPICO_RS05230
uniprot id: F4GJH4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

760011:SPICO RS06120
gene id: 760011:SPICO_RS06120
uniprot id: F4GL67
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

760011:SPICO RS06345
gene id: 760011:SPICO_RS06345
uniprot id: F4GLQ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

760011:SPICO RS03355
gene id: 760011:SPICO_RS03355
uniprot id: F4GKX5
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

760011:SPICO RS08460
gene id: 760011:SPICO_RS08460
uniprot id: F4GKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

760011:SPICO RS05155
gene id: 760011:SPICO_RS05155
uniprot id: F4GJF8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

760011:SPICO RS01455
gene id: 760011:SPICO_RS01455
uniprot id: F4GH50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

760011:SPICO RS03035
gene id: 760011:SPICO_RS03035
uniprot id: F4GK55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

760011:SPICO RS08245
gene id: 760011:SPICO_RS08245
uniprot id: F4GJR9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

760011:SPICO RS03960
gene id: 760011:SPICO_RS03960
uniprot id: F4GH97
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS02740
gene id: 760011:SPICO_RS02740
uniprot id: F4GJD0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS00085
gene id: 760011:SPICO_RS00085
uniprot id: F4GIA0
names: Similarity
messages: Belongs to the FGGY kinase family.

760011:SPICO RS04675
gene id: 760011:SPICO_RS04675
uniprot id: F4GIJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

760011:SPICO RS00105
gene id: 760011:SPICO_RS00105
uniprot id: F4GIA4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

760011:SPICO RS06525
gene id: 760011:SPICO_RS06525
uniprot id: F4GM08
names: Similarity
messages: Belongs to the LacAB/RpiB family.

760011:SPICO RS08750
gene id: 760011:SPICO_RS08750
uniprot id: F4GL84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

760011:SPICO RS06090
gene id: 760011:SPICO_RS06090
uniprot id: F4GL61
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

760011:SPICO RS01785
gene id: 760011:SPICO_RS01785
uniprot id: F4GHP9
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

760011:SPICO RS09430
gene id: 760011:SPICO_RS09430
uniprot id: F4GM01
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

760011:SPICO RS00050
gene id: 760011:SPICO_RS00050
uniprot id: F4GI93
names: Similarity
messages: Belongs to the archaeal-type GPI family.

760011:SPICO RS03890
gene id: 760011:SPICO_RS03890
uniprot id: F4GLL3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

760011:SPICO RS05485
gene id: 760011:SPICO_RS05485
uniprot id: F4GK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS06105
gene id: 760011:SPICO_RS06105
uniprot id: F4GL64
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

760011:SPICO RS08895
gene id: 760011:SPICO_RS08895
uniprot id: F4GLB1
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

760011:SPICO RS00705
gene id: 760011:SPICO_RS00705
uniprot id: F4GJV6
names: Similarity
messages: Belongs to the PspA/IM30 family.

760011:SPICO RS03800
gene id: 760011:SPICO_RS03800
uniprot id: F4GLJ9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

760011:SPICO RS00315
gene id: 760011:SPICO_RS00315
uniprot id: F4GJ11
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS03055
gene id: 760011:SPICO_RS03055
uniprot id: F4GK59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

760011:SPICO RS08710
gene id: 760011:SPICO_RS08710
uniprot id: F4GL76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

760011:SPICO RS01040
gene id: 760011:SPICO_RS01040
uniprot id: F4GKP0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01300
gene id: 760011:SPICO_RS01300
uniprot id: F4GH21
names: Similarity
messages: Belongs to the catalase family.

760011:SPICO RS05445
gene id: 760011:SPICO_RS05445
uniprot id: F4GK87
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

760011:SPICO RS02490
gene id: 760011:SPICO_RS02490
uniprot id: F4GJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS07840
gene id: 760011:SPICO_RS07840
uniprot id: F4GIX2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

760011:SPICO RS01490
gene id: 760011:SPICO_RS01490
uniprot id: F4GH56
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08390
gene id: 760011:SPICO_RS08390
uniprot id: F4GKG0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS00880
gene id: 760011:SPICO_RS00880
uniprot id: F4GJZ1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS09200
gene id: 760011:SPICO_RS09200
uniprot id: F4GLW1
names: Similarity
messages: Belongs to the peptidase S66 family.

760011:SPICO RS06110
gene id: 760011:SPICO_RS06110
uniprot id: F4GL65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

760011:SPICO RS01420
gene id: 760011:SPICO_RS01420
uniprot id: F4GH43
names: Similarity
messages: Belongs to the Nth/MutY family.

760011:SPICO RS08200
gene id: 760011:SPICO_RS08200
uniprot id: F4GJR1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

760011:SPICO RS00010
gene id: 760011:SPICO_RS00010
uniprot id: F4GI85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

760011:SPICO RS03200
gene id: 760011:SPICO_RS03200
uniprot id: F4GKU3
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

760011:SPICO RS05165
gene id: 760011:SPICO_RS05165
uniprot id: F4GJG0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

760011:SPICO RS07580
gene id: 760011:SPICO_RS07580
uniprot id: F4GIS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02900
gene id: 760011:SPICO_RS02900
uniprot id: F4GK29
names: Similarity
messages: Belongs to the glutamate synthase family.

760011:SPICO RS08605
gene id: 760011:SPICO_RS08605
uniprot id: F4GKK2
names: Similarity
messages: Belongs to the TlyA family.

760011:SPICO RS00865
gene id: 760011:SPICO_RS00865
uniprot id: F4GJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

760011:SPICO RS02395
gene id: 760011:SPICO_RS02395
uniprot id: F4GJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

760011:SPICO RS07035
gene id: 760011:SPICO_RS07035
uniprot id: F4GHJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS04420
gene id: 760011:SPICO_RS04420
uniprot id: F4GHW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

760011:SPICO RS02615
gene id: 760011:SPICO_RS02615
uniprot id: F4GJA7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

760011:SPICO RS01990
gene id: 760011:SPICO_RS01990
uniprot id: F4GHT8
names: Similarity
messages: Belongs to the RecJ family.

760011:SPICO RS05160
gene id: 760011:SPICO_RS05160
uniprot id: F4GJF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

760011:SPICO RS02975
gene id: 760011:SPICO_RS02975
uniprot id: F4GK44
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS09110
gene id: 760011:SPICO_RS09110
uniprot id: F4GLU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

760011:SPICO RS02230
gene id: 760011:SPICO_RS02230
uniprot id: F4GIG3
names: Similarity
messages: Belongs to the disproportionating enzyme family.

760011:SPICO RS05440
gene id: 760011:SPICO_RS05440
uniprot id: F4GK86
names: Similarity
messages: Belongs to the hexokinase family.

760011:SPICO RS08700
gene id: 760011:SPICO_RS08700
uniprot id: F4GL74
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

760011:SPICO RS04795
gene id: 760011:SPICO_RS04795
uniprot id: F4GIL9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

760011:SPICO RS00005
gene id: 760011:SPICO_RS00005
uniprot id: F4GI84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

760011:SPICO RS05595
gene id: 760011:SPICO_RS05595
uniprot id: F4GKB6
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS01025
gene id: 760011:SPICO_RS01025
uniprot id: F4GKN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

760011:SPICO RS06130
gene id: 760011:SPICO_RS06130
uniprot id: F4GLL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

760011:SPICO RS03590
gene id: 760011:SPICO_RS03590
uniprot id: F4GLF8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

760011:SPICO RS05405
gene id: 760011:SPICO_RS05405
uniprot id: F4GK79
names: Similarity
messages: Belongs to the thioredoxin family.

760011:SPICO RS06415
gene id: 760011:SPICO_RS06415
uniprot id: F4GLR9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

760011:SPICO RS08585
gene id: 760011:SPICO_RS08585
uniprot id: F4GKJ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS06385
gene id: 760011:SPICO_RS06385
uniprot id: F4GLR3
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

760011:SPICO RS03160
gene id: 760011:SPICO_RS03160
uniprot id: F4GKT8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

760011:SPICO RS09365
gene id: 760011:SPICO_RS09365
uniprot id: F4GLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

760011:SPICO RS03955
gene id: 760011:SPICO_RS03955
uniprot id: F4GH96
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

760011:SPICO RS04740
gene id: 760011:SPICO_RS04740
uniprot id: F4GIK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

760011:SPICO RS08445
gene id: 760011:SPICO_RS08445
uniprot id: F4GKH1
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS08905
gene id: 760011:SPICO_RS08905
uniprot id: F4GLB3
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS04595
gene id: 760011:SPICO_RS04595
uniprot id: F4GI01
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Secreted

760011:SPICO RS05640
gene id: 760011:SPICO_RS05640
uniprot id: F4GKC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

760011:SPICO RS07255
gene id: 760011:SPICO_RS07255
uniprot id: F4GI27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

760011:SPICO RS09510
gene id: 760011:SPICO_RS09510
uniprot id: F4GM82
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

760011:SPICO RS01845
gene id: 760011:SPICO_RS01845
uniprot id: F4GHR0
names: Subcellular Location Annotation
messages: Membrane

760011:SPICO RS06495
gene id: 760011:SPICO_RS06495
uniprot id: F4GM03
names: Similarity
messages: Belongs to the LOG family.

760011:SPICO RS04720
gene id: 760011:SPICO_RS04720
uniprot id: F4GIK5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

760011:SPICO RS08690
gene id: 760011:SPICO_RS08690
uniprot id: F4GL72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

760011:SPICO RS03965
gene id: 760011:SPICO_RS03965
uniprot id: F4GH98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

760011:SPICO RS07040
gene id: 760011:SPICO_RS07040
uniprot id: F4GHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.