74969:fad RS00825
gene id: 74969:fad_RS00825
uniprot id: A0A1V0N1T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

74969:fad RS05730
gene id: 74969:fad_RS05730
uniprot id: A0A1V0N4H6
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

74969:fad RS05175
gene id: 74969:fad_RS05175
uniprot id: A0A1V0N494
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

74969:fad RS07890
gene id: 74969:fad_RS07890
uniprot id: A0A1V0N5Q1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

74969:fad RS07190
gene id: 74969:fad_RS07190
uniprot id: A0A1V0N5C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

74969:fad RS03090
gene id: 74969:fad_RS03090
uniprot id: A0A1V0N320
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

74969:fad RS02495
gene id: 74969:fad_RS02495
uniprot id: A0A1V0N2U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS08395
gene id: 74969:fad_RS08395
uniprot id: A0A1V0N5Y5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

74969:fad RS03780
gene id: 74969:fad_RS03780
uniprot id: A0A7K4FNC5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS00990
gene id: 74969:fad_RS00990
uniprot id: A0A1V0N1V1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

74969:fad RS00240
gene id: 74969:fad_RS00240
uniprot id: A0A1V0N1L9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

74969:fad RS02250
gene id: 74969:fad_RS02250
uniprot id: A0A1V0N2J2
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS02940
gene id: 74969:fad_RS02940
uniprot id: A0A1V0N337
names: Similarity
messages: Belongs to the HypE family.

74969:fad RS00160
gene id: 74969:fad_RS00160
uniprot id: A0A1V0N1F4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

74969:fad RS08160
gene id: 74969:fad_RS08160
uniprot id: A0A1V0N5W0
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

74969:fad RS02005
gene id: 74969:fad_RS02005
uniprot id: A0A1V0N2K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

74969:fad RS01105
gene id: 74969:fad_RS01105
uniprot id: A0A1V0N235
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

74969:fad RS05760
gene id: 74969:fad_RS05760
uniprot id: A0A7K4FPN8
names: Caution
names: Similarity
messages: Belongs to the SAICAR synthetase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS00650
gene id: 74969:fad_RS00650
uniprot id: A0A1V0N1R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

74969:fad RS03150
gene id: 74969:fad_RS03150
uniprot id: A0A1V0N378
names: Similarity
messages: Belongs to the UPF0235 family.

74969:fad RS08340
gene id: 74969:fad_RS08340
uniprot id: A0A1V0N5Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

74969:fad RS07455
gene id: 74969:fad_RS07455
uniprot id: A0A1V0N5K4
names: Similarity
messages: Belongs to the arsA ATPase family.

74969:fad RS00260
gene id: 74969:fad_RS00260
uniprot id: A0A1V0N1H5
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS01275
gene id: 74969:fad_RS01275
uniprot id: A0A1V0N202
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

74969:fad RS03860
gene id: 74969:fad_RS03860
uniprot id: A0A1V0N3N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

74969:fad RS07900
gene id: 74969:fad_RS07900
uniprot id: A0A1V0N5T9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

74969:fad RS01225
gene id: 74969:fad_RS01225
uniprot id: A0A7K4FKM3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS01965
gene id: 74969:fad_RS01965
uniprot id: A0A1V0N2I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

74969:fad RS01185
gene id: 74969:fad_RS01185
uniprot id: A0A1V0N230
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

74969:fad RS00830
gene id: 74969:fad_RS00830
uniprot id: A0A1V0N1W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

74969:fad RS07460
gene id: 74969:fad_RS07460
uniprot id: A0A1V0N5H4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

74969:fad RS07445
gene id: 74969:fad_RS07445
uniprot id: A0A1V0N5I4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

74969:fad RS08090
gene id: 74969:fad_RS08090
uniprot id: A0A1V0N5R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

74969:fad RS00220
gene id: 74969:fad_RS00220
uniprot id: A0A1V0N1F2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

74969:fad RS07980
gene id: 74969:fad_RS07980
uniprot id: A0A1V0N5U6
names: Similarity
messages: Belongs to the ComB family.

74969:fad RS01180
gene id: 74969:fad_RS01180
uniprot id: A0A1V0N248
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

74969:fad RS01400
gene id: 74969:fad_RS01400
uniprot id: A0A1V0N276
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

74969:fad RS00630
gene id: 74969:fad_RS00630
uniprot id: A0A1V0N1R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

74969:fad RS07860
gene id: 74969:fad_RS07860
uniprot id: A0A1V0N5Q3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

74969:fad RS08895
gene id: 74969:fad_RS08895
uniprot id: A0A1V0N689
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

74969:fad RS07910
gene id: 74969:fad_RS07910
uniprot id: A0A7K4FKI2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS08940
gene id: 74969:fad_RS08940
uniprot id: A0A1V0N6B3
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

74969:fad RS01580
gene id: 74969:fad_RS01580
uniprot id: A0A1V0N289
names: Similarity
messages: Belongs to the pirin family.

74969:fad RS02145
gene id: 74969:fad_RS02145
uniprot id: A0A1V0N2H3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

74969:fad RS00935
gene id: 74969:fad_RS00935
uniprot id: A0A1V0N1U6
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

74969:fad RS07640
gene id: 74969:fad_RS07640
uniprot id: A0A1V0N5H9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

74969:fad RS00810
gene id: 74969:fad_RS00810
uniprot id: A0A1V0N1W3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

74969:fad RS02120
gene id: 74969:fad_RS02120
uniprot id: A0A1V0N2M2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

74969:fad RS07290
gene id: 74969:fad_RS07290
uniprot id: A0A1V0N5E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

74969:fad RS00675
gene id: 74969:fad_RS00675
uniprot id: A0A1V0N1Q5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

74969:fad RS02075
gene id: 74969:fad_RS02075
uniprot id: A0A1V0N2I0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

74969:fad RS08665
gene id: 74969:fad_RS08665
uniprot id: A0A1V0N681
names: Similarity
messages: Belongs to the BCKDHA family.

74969:fad RS02560
gene id: 74969:fad_RS02560
uniprot id: A0A1V0N2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

74969:fad RS01705
gene id: 74969:fad_RS01705
uniprot id: A0A1V0N2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

74969:fad RS01710
gene id: 74969:fad_RS01710
uniprot id: A0A1V0N2A6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

74969:fad RS02815
gene id: 74969:fad_RS02815
uniprot id: A0A1V0N312
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS08145
gene id: 74969:fad_RS08145
uniprot id: A0A1V0N5S5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

74969:fad RS07865
gene id: 74969:fad_RS07865
uniprot id: A0A1V0N5N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

74969:fad RS02375
gene id: 74969:fad_RS02375
uniprot id: A0A1V0N2R8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

74969:fad RS07040
gene id: 74969:fad_RS07040
uniprot id: A0A1V0N571
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

74969:fad RS05330
gene id: 74969:fad_RS05330
uniprot id: A0A1V0N4A8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

74969:fad RS02955
gene id: 74969:fad_RS02955
uniprot id: A0A1V0N2Y2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

74969:fad RS06720
gene id: 74969:fad_RS06720
uniprot id: A0A1V0N514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

74969:fad RS00655
gene id: 74969:fad_RS00655
uniprot id: A0A1V0N1U2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

74969:fad RS00785
gene id: 74969:fad_RS00785
uniprot id: A0A1V0N1R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

74969:fad RS00855
gene id: 74969:fad_RS00855
uniprot id: A0A1V0N1Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

74969:fad RS02130
gene id: 74969:fad_RS02130
uniprot id: A0A1V0N2J0
names: Similarity
messages: Belongs to the ice-binding protein family.

74969:fad RS07960
gene id: 74969:fad_RS07960
uniprot id: A0A1V0N5S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

74969:fad RS00780
gene id: 74969:fad_RS00780
uniprot id: A0A1V0N1V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

74969:fad RS08020
gene id: 74969:fad_RS08020
uniprot id: A0A7K4FKX8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS00880
gene id: 74969:fad_RS00880
uniprot id: A0A1V0N1X0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

74969:fad RS08620
gene id: 74969:fad_RS08620
uniprot id: A0A1V0N679
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS08885
gene id: 74969:fad_RS08885
uniprot id: A0A1V0N660
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS05850
gene id: 74969:fad_RS05850
uniprot id: A0A7K4FNS5
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS00845
gene id: 74969:fad_RS00845
uniprot id: A0A1V0N1S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

74969:fad RS00865
gene id: 74969:fad_RS00865
uniprot id: A0A1V0N1Y8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

74969:fad RS07225
gene id: 74969:fad_RS07225
uniprot id: A0A1V0N5F0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

74969:fad RS06375
gene id: 74969:fad_RS06375
uniprot id: A0A7K4FLH4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS08990
gene id: 74969:fad_RS08990
uniprot id: A0A1V0N6C1
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

74969:fad RS01405
gene id: 74969:fad_RS01405
uniprot id: A0A1V0N247
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

74969:fad RS01735
gene id: 74969:fad_RS01735
uniprot id: A0A1V0N2B9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

74969:fad RS01640
gene id: 74969:fad_RS01640
uniprot id: A0A1V0N2C9
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

74969:fad RS08050
gene id: 74969:fad_RS08050
uniprot id: A0A1V0N5W9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

74969:fad RS02620
gene id: 74969:fad_RS02620
uniprot id: A0A1V0N2W4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

74969:fad RS08695
gene id: 74969:fad_RS08695
uniprot id: A0A7K4FPX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS06425
gene id: 74969:fad_RS06425
uniprot id: A0A1V0N503
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

74969:fad RS02150
gene id: 74969:fad_RS02150
uniprot id: A0A1V0N2N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

74969:fad RS08015
gene id: 74969:fad_RS08015
uniprot id: A0A1V0N5R1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

74969:fad RS05640
gene id: 74969:fad_RS05640
uniprot id: A0A1V0N4F4
names: Similarity
messages: Belongs to the MoaD family.

74969:fad RS00790
gene id: 74969:fad_RS00790
uniprot id: A0A1V0N1X6
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

74969:fad RS01620
gene id: 74969:fad_RS01620
uniprot id: A0A7K4FMW9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS05780
gene id: 74969:fad_RS05780
uniprot id: A0A1V0N4L3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

74969:fad RS00245
gene id: 74969:fad_RS00245
uniprot id: A0A1V0N1L1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

74969:fad RS07680
gene id: 74969:fad_RS07680
uniprot id: A0A1V0N5L4
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS07270
gene id: 74969:fad_RS07270
uniprot id: A0A1V0N5D6
names: Subcellular Location Annotation
messages: Cytoplasm

74969:fad RS02820
gene id: 74969:fad_RS02820
uniprot id: A0A1V0N339
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

74969:fad RS01510
gene id: 74969:fad_RS01510
uniprot id: A0A7K4FPT2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS01095
gene id: 74969:fad_RS01095
uniprot id: A0A1V0N217
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

74969:fad RS01720
gene id: 74969:fad_RS01720
uniprot id: A0A1V0N290
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

74969:fad RS08005
gene id: 74969:fad_RS08005
uniprot id: A0A1V0N5P4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS01660
gene id: 74969:fad_RS01660
uniprot id: A0A1V0N296
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

74969:fad RS01010
gene id: 74969:fad_RS01010
uniprot id: A0A1V0N212
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

74969:fad RS08920
gene id: 74969:fad_RS08920
uniprot id: A0A7K4FNC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS00205
gene id: 74969:fad_RS00205
uniprot id: A0A1V0N1J9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

74969:fad RS01415
gene id: 74969:fad_RS01415
uniprot id: A0A1V0N231
names: Similarity
messages: Belongs to the UPF0179 family.

74969:fad RS00800
gene id: 74969:fad_RS00800
uniprot id: A0A1V0N1U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

74969:fad RS08935
gene id: 74969:fad_RS08935
uniprot id: A0A1V0N666
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

74969:fad RS05635
gene id: 74969:fad_RS05635
uniprot id: A0A1V0N4K3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS02555
gene id: 74969:fad_RS02555
uniprot id: A0A1V0N2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

74969:fad RS01150
gene id: 74969:fad_RS01150
uniprot id: A0A1V0N1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

74969:fad RS01000
gene id: 74969:fad_RS01000
uniprot id: A0A1V0N1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

74969:fad RS06745
gene id: 74969:fad_RS06745
uniprot id: A0A1V0N528
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

74969:fad RS01290
gene id: 74969:fad_RS01290
uniprot id: A0A1V0N261
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

74969:fad RS01635
gene id: 74969:fad_RS01635
uniprot id: A0A1V0N2D3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

74969:fad RS08785
gene id: 74969:fad_RS08785
uniprot id: A0A1V0N642
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS02840
gene id: 74969:fad_RS02840
uniprot id: A0A1V0N2V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

74969:fad RS00870
gene id: 74969:fad_RS00870
uniprot id: A0A1V0N1X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

74969:fad RS07510
gene id: 74969:fad_RS07510
uniprot id: A0A7K4FR71
names: Caution
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS06905
gene id: 74969:fad_RS06905
uniprot id: A0A1V0N562
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS00075
gene id: 74969:fad_RS00075
uniprot id: A0A7K4FN21
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS07465
gene id: 74969:fad_RS07465
uniprot id: A0A1V0N5F3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

74969:fad RS00915
gene id: 74969:fad_RS00915
uniprot id: A0A1V0N1Z9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

74969:fad RS03095
gene id: 74969:fad_RS03095
uniprot id: A0A1V0N361
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

74969:fad RS02325
gene id: 74969:fad_RS02325
uniprot id: A0A1V0N2Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

74969:fad RS02630
gene id: 74969:fad_RS02630
uniprot id: A0A1V0N2Z7
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

74969:fad RS07985
gene id: 74969:fad_RS07985
uniprot id: A0A1V0N5V4
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

74969:fad RS03045
gene id: 74969:fad_RS03045
uniprot id: A0A1V0N352
names: Similarity
messages: Belongs to the complex I subunit 3 family.

74969:fad RS09020
gene id: 74969:fad_RS09020
uniprot id: A0A1V0N6C2
names: Similarity
messages: Belongs to the ZPR1 family.

74969:fad RS02020
gene id: 74969:fad_RS02020
uniprot id: A0A1V0N2H0
names: Similarity
messages: Belongs to the peptidase M24B family.

74969:fad RS00875
gene id: 74969:fad_RS00875
uniprot id: A0A1V0N1U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

74969:fad RS02900
gene id: 74969:fad_RS02900
uniprot id: A0A1V0N327
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

74969:fad RS02910
gene id: 74969:fad_RS02910
uniprot id: A0A1V0N2X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

74969:fad RS05420
gene id: 74969:fad_RS05420
uniprot id: A0A1V0N4G1
names: Similarity
messages: Belongs to the citrate synthase family.

74969:fad RS08670
gene id: 74969:fad_RS08670
uniprot id: A0A7K4FPK4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS03050
gene id: 74969:fad_RS03050
uniprot id: A0A7K4FM49
names: Caution
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS01730
gene id: 74969:fad_RS01730
uniprot id: A0A1V0N291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

74969:fad RS05825
gene id: 74969:fad_RS05825
uniprot id: A0A1V0N4M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

74969:fad RS07255
gene id: 74969:fad_RS07255
uniprot id: A0A1V0N5B8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

74969:fad RS06705
gene id: 74969:fad_RS06705
uniprot id: A0A1V0N547
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS01265
gene id: 74969:fad_RS01265
uniprot id: A0A1V0N200
names: Similarity
messages: Belongs to the MCM family.

74969:fad RS07315
gene id: 74969:fad_RS07315
uniprot id: A0A7K4FL88
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS07895
gene id: 74969:fad_RS07895
uniprot id: A0A1V0N5M4
names: Similarity
messages: Belongs to the pyruvate kinase family.

74969:fad RS09105
gene id: 74969:fad_RS09105
uniprot id: A0A1V0N6D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

74969:fad RS07555
gene id: 74969:fad_RS07555
uniprot id: A0A1V0N5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

74969:fad RS09005
gene id: 74969:fad_RS09005
uniprot id: A0A1V0N6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

74969:fad RS07695
gene id: 74969:fad_RS07695
uniprot id: A0A1V0N5I8
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

74969:fad RS01450
gene id: 74969:fad_RS01450
uniprot id: A0A1V0N287
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

74969:fad RS08110
gene id: 74969:fad_RS08110
uniprot id: A0A1V0N5T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

74969:fad RS00985
gene id: 74969:fad_RS00985
uniprot id: A0A7K4FMW1
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS02270
gene id: 74969:fad_RS02270
uniprot id: A0A1V0N2P8
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

74969:fad RS02435
gene id: 74969:fad_RS02435
uniprot id: Q2PCE2
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

74969:fad RS09180
gene id: 74969:fad_RS09180
uniprot id: A0A1V0N6I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

74969:fad RS01845
gene id: 74969:fad_RS01845
uniprot id: A0A1V0N2G5
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

74969:fad RS02925
gene id: 74969:fad_RS02925
uniprot id: A0A1V0N360
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

74969:fad RS00370
gene id: 74969:fad_RS00370
uniprot id: A0A1V0N1L0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

74969:fad RS09160
gene id: 74969:fad_RS09160
uniprot id: A0A1V0N6D5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

74969:fad RS02315
gene id: 74969:fad_RS02315
uniprot id: A0A1V0N2L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

74969:fad RS00885
gene id: 74969:fad_RS00885
uniprot id: A0A1V0N1T9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

74969:fad RS02415
gene id: 74969:fad_RS02415
uniprot id: A0A7K4FRY4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS07925
gene id: 74969:fad_RS07925
uniprot id: A0A1V0N5S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

74969:fad RS07020
gene id: 74969:fad_RS07020
uniprot id: A0A1V0N5A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

74969:fad RS08115
gene id: 74969:fad_RS08115
uniprot id: A0A1V0N5T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

74969:fad RS00805
gene id: 74969:fad_RS00805
uniprot id: A0A7K4FKU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS02545
gene id: 74969:fad_RS02545
uniprot id: A0A1V0N2V9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

74969:fad RS07855
gene id: 74969:fad_RS07855
uniprot id: A0A1V0N5L1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

74969:fad RS02870
gene id: 74969:fad_RS02870
uniprot id: A0A1V0N348
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS00200
gene id: 74969:fad_RS00200
uniprot id: A0A1V0N1K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

74969:fad RS00210
gene id: 74969:fad_RS00210
uniprot id: A0A1V0N1G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

74969:fad RS06810
gene id: 74969:fad_RS06810
uniprot id: A0A1V0N573
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

74969:fad RS09060
gene id: 74969:fad_RS09060
uniprot id: A0A1V0N6B4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

74969:fad RS08625
gene id: 74969:fad_RS08625
uniprot id: A0A1V0N641
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

74969:fad RS07235
gene id: 74969:fad_RS07235
uniprot id: A0A1V0N5G1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

74969:fad RS00670
gene id: 74969:fad_RS00670
uniprot id: A0A1V0N1T4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

74969:fad RS07100
gene id: 74969:fad_RS07100
uniprot id: A0A1V0N577
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

74969:fad RS05805
gene id: 74969:fad_RS05805
uniprot id: A0A1V0N4L8
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS07700
gene id: 74969:fad_RS07700
uniprot id: A0A1V0N5M6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

74969:fad RS09025
gene id: 74969:fad_RS09025
uniprot id: A0A1V0N685
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS00665
gene id: 74969:fad_RS00665
uniprot id: A0A1V0N1U4
names: Similarity
messages: Belongs to the HAM1 NTPase family.

74969:fad RS07970
gene id: 74969:fad_RS07970
uniprot id: A0A1V0N5Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

74969:fad RS02525
gene id: 74969:fad_RS02525
uniprot id: A0A1V0N2V0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

74969:fad RS02030
gene id: 74969:fad_RS02030
uniprot id: A0A1V0N2F6
names: Subcellular Location Annotation
messages: Cytoplasm

74969:fad RS06050
gene id: 74969:fad_RS06050
uniprot id: A0A1V0N4N6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

74969:fad RS08010
gene id: 74969:fad_RS08010
uniprot id: A0A1V0N5T2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

74969:fad RS00905
gene id: 74969:fad_RS00905
uniprot id: A0A1V0N1Z5
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS02035
gene id: 74969:fad_RS02035
uniprot id: A0A1V0N2L7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

74969:fad RS07610
gene id: 74969:fad_RS07610
uniprot id: A0A7K4FNF0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

74969:fad RS08750
gene id: 74969:fad_RS08750
uniprot id: A0A1V0N653
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

74969:fad RS01325
gene id: 74969:fad_RS01325
uniprot id: A0A1V0N216
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS02260
gene id: 74969:fad_RS02260
uniprot id: A0A1V0N2J5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

74969:fad RS02065
gene id: 74969:fad_RS02065
uniprot id: A0A1V0N2M6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

74969:fad RS00840
gene id: 74969:fad_RS00840
uniprot id: A0A1V0N1Y4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

74969:fad RS03085
gene id: 74969:fad_RS03085
uniprot id: A0A1V0N377
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS00360
gene id: 74969:fad_RS00360
uniprot id: A0A1V0N1M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

74969:fad RS00090
gene id: 74969:fad_RS00090
uniprot id: A0A1V0N1I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

74969:fad RS02275
gene id: 74969:fad_RS02275
uniprot id: A0A1V0N2P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

74969:fad RS00365
gene id: 74969:fad_RS00365
uniprot id: A0A1V0N1J5
names: Similarity
messages: Belongs to the PDCD5 family.

74969:fad RS08890
gene id: 74969:fad_RS08890
uniprot id: A0A1V0N6A1
names: Similarity
messages: Belongs to the UMP kinase family.

74969:fad RS02710
gene id: 74969:fad_RS02710
uniprot id: A0A1V0N2T6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

74969:fad RS05430
gene id: 74969:fad_RS05430
uniprot id: A0A1V0N4E5
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS00900
gene id: 74969:fad_RS00900
uniprot id: A0A1V0N1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

74969:fad RS00795
gene id: 74969:fad_RS00795
uniprot id: A0A1V0N1R1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

74969:fad RS00660
gene id: 74969:fad_RS00660
uniprot id: A0A1V0N1T3
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

74969:fad RS03065
gene id: 74969:fad_RS03065
uniprot id: A0A1V0N308
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS02745
gene id: 74969:fad_RS02745
uniprot id: A0A1V0N2T3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

74969:fad RS03030
gene id: 74969:fad_RS03030
uniprot id: A0A1V0N379
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

74969:fad RS01145
gene id: 74969:fad_RS01145
uniprot id: A0A1V0N227
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS09140
gene id: 74969:fad_RS09140
uniprot id: A0A1V0N6A9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

74969:fad RS03100
gene id: 74969:fad_RS03100
uniprot id: A0A1V0N303
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS03965
gene id: 74969:fad_RS03965
uniprot id: A0A1V0N3Q4
names: Subcellular Location Annotation
messages: Membrane

74969:fad RS06865
gene id: 74969:fad_RS06865
uniprot id: A0A1V0N582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

74969:fad RS05620
gene id: 74969:fad_RS05620
uniprot id: A0A1V0N4I9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

74969:fad RS01525
gene id: 74969:fad_RS01525
uniprot id: A0A1V0N253
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

74969:fad RS01420
gene id: 74969:fad_RS01420
uniprot id: A0A1V0N293
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

74969:fad RS07975
gene id: 74969:fad_RS07975
uniprot id: A0A1V0N5T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

74969:fad RS02280
gene id: 74969:fad_RS02280
uniprot id: A0A1V0N2S2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

74969:fad RS05410
gene id: 74969:fad_RS05410
uniprot id: A0A1V0N4E3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

74969:fad RS01195
gene id: 74969:fad_RS01195
uniprot id: A0A1V0N236
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

74969:fad RS01610
gene id: 74969:fad_RS01610
uniprot id: A0A1V0N2B4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

74969:fad RS07965
gene id: 74969:fad_RS07965
uniprot id: A0A1V0N5Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

74969:fad RS04170
gene id: 74969:fad_RS04170
uniprot id: A0A1V0N3T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

74969:fad RS02160
gene id: 74969:fad_RS02160
uniprot id: A0A1V0N2H8
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

74969:fad RS07795
gene id: 74969:fad_RS07795
uniprot id: A0A1V0N5R9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

74969:fad RS07015
gene id: 74969:fad_RS07015
uniprot id: A0A1V0N575
names: Caution
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

74969:fad RS07920
gene id: 74969:fad_RS07920
uniprot id: A0A1V0N5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

74969:fad RS00775
gene id: 74969:fad_RS00775
uniprot id: A0A1V0N1S8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.