749222:NITSA RS05700
gene id: 749222:NITSA_RS05700
uniprot id: E6WY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

749222:NITSA RS00050
gene id: 749222:NITSA_RS00050
uniprot id: E6WXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

749222:NITSA RS02265
gene id: 749222:NITSA_RS02265
uniprot id: E6X0C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

749222:NITSA RS09975
gene id: 749222:NITSA_RS09975
uniprot id: E6X2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

749222:NITSA RS01845
gene id: 749222:NITSA_RS01845
uniprot id: E6WZX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

749222:NITSA RS02210
gene id: 749222:NITSA_RS02210
uniprot id: E6X0B4
names: Similarity
messages: Belongs to the RutC family.

749222:NITSA RS06640
gene id: 749222:NITSA_RS06640
uniprot id: E6WYX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

749222:NITSA RS06220
gene id: 749222:NITSA_RS06220
uniprot id: E6WYG8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

749222:NITSA RS04160
gene id: 749222:NITSA_RS04160
uniprot id: E6X2L3
names: Similarity
messages: Belongs to the leucine-binding protein family.

749222:NITSA RS02485
gene id: 749222:NITSA_RS02485
uniprot id: E6X0N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

749222:NITSA RS07950
gene id: 749222:NITSA_RS07950
uniprot id: E6X0H0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

749222:NITSA RS07645
gene id: 749222:NITSA_RS07645
uniprot id: E6X034
names: Similarity
messages: Belongs to the peptidase S41A family.

749222:NITSA RS01940
gene id: 749222:NITSA_RS01940
uniprot id: E6WZZ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS02975
gene id: 749222:NITSA_RS02975
uniprot id: E6X150
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

749222:NITSA RS04770
gene id: 749222:NITSA_RS04770
uniprot id: E6X351
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

749222:NITSA RS08595
gene id: 749222:NITSA_RS08595
uniprot id: E6X179
names: Function
names: Similarity
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

749222:NITSA RS03780
gene id: 749222:NITSA_RS03780
uniprot id: E6X203
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01050
gene id: 749222:NITSA_RS01050
uniprot id: E6WZ23
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS09810
gene id: 749222:NITSA_RS09810
uniprot id: E6X2I9
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS02250
gene id: 749222:NITSA_RS02250
uniprot id: E6X0C2
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

749222:NITSA RS08820
gene id: 749222:NITSA_RS08820
uniprot id: E6X1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

749222:NITSA RS10695
gene id: 749222:NITSA_RS10695
uniprot id: E6X3L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

749222:NITSA RS07480
gene id: 749222:NITSA_RS07480
uniprot id: E6X001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

749222:NITSA RS00980
gene id: 749222:NITSA_RS00980
uniprot id: E6WZ09
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS00410
gene id: 749222:NITSA_RS00410
uniprot id: E6WYA4
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

749222:NITSA RS03680
gene id: 749222:NITSA_RS03680
uniprot id: E6X1Y4
names: Similarity
messages: Belongs to the UPF0166 family.

749222:NITSA RS10220
gene id: 749222:NITSA_RS10220
uniprot id: E6X2Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

749222:NITSA RS05015
gene id: 749222:NITSA_RS05015
uniprot id: E6X3G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

749222:NITSA RS06385
gene id: 749222:NITSA_RS06385
uniprot id: E6WYS8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

749222:NITSA RS00355
gene id: 749222:NITSA_RS00355
uniprot id: E6WY93
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

749222:NITSA RS02830
gene id: 749222:NITSA_RS02830
uniprot id: E6X122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS01680
gene id: 749222:NITSA_RS01680
uniprot id: E6WZU1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

749222:NITSA RS02275
gene id: 749222:NITSA_RS02275
uniprot id: E6X0C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

749222:NITSA RS04595
gene id: 749222:NITSA_RS04595
uniprot id: E6X320
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

749222:NITSA RS05155
gene id: 749222:NITSA_RS05155
uniprot id: E6X3J4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

749222:NITSA RS08095
gene id: 749222:NITSA_RS08095
uniprot id: E6X0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

749222:NITSA RS04000
gene id: 749222:NITSA_RS04000
uniprot id: E6X2B3
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

749222:NITSA RS05365
gene id: 749222:NITSA_RS05365
uniprot id: E6WXQ4
names: Similarity
messages: Belongs to the YoeB family.

749222:NITSA RS10670
gene id: 749222:NITSA_RS10670
uniprot id: E6X3D9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01280
gene id: 749222:NITSA_RS01280
uniprot id: E6WZE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

749222:NITSA RS04180
gene id: 749222:NITSA_RS04180
uniprot id: E6X2L7
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

749222:NITSA RS09790
gene id: 749222:NITSA_RS09790
uniprot id: E6X2I5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

749222:NITSA RS07655
gene id: 749222:NITSA_RS07655
uniprot id: E6X036
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

749222:NITSA RS09640
gene id: 749222:NITSA_RS09640
uniprot id: E6X2F3
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07025
gene id: 749222:NITSA_RS07025
uniprot id: E6WZC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

749222:NITSA RS01530
gene id: 749222:NITSA_RS01530
uniprot id: E6WZI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

749222:NITSA RS09565
gene id: 749222:NITSA_RS09565
uniprot id: E6X274
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

749222:NITSA RS06415
gene id: 749222:NITSA_RS06415
uniprot id: E6WYT4
names: Similarity
messages: Belongs to the citrate synthase family.

749222:NITSA RS05110
gene id: 749222:NITSA_RS05110
uniprot id: E6X3I5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

749222:NITSA RS06850
gene id: 749222:NITSA_RS06850
uniprot id: E6WZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

749222:NITSA RS09905
gene id: 749222:NITSA_RS09905
uniprot id: E6X2K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

749222:NITSA RS06205
gene id: 749222:NITSA_RS06205
uniprot id: E6WYG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

749222:NITSA RS03530
gene id: 749222:NITSA_RS03530
uniprot id: E6X1V4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

749222:NITSA RS06670
gene id: 749222:NITSA_RS06670
uniprot id: E6WYY0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

749222:NITSA RS00775
gene id: 749222:NITSA_RS00775
uniprot id: E6WYP8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

749222:NITSA RS06760
gene id: 749222:NITSA_RS06760
uniprot id: E6WZ72
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

749222:NITSA RS10375
gene id: 749222:NITSA_RS10375
uniprot id: E6X388
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

749222:NITSA RS08410
gene id: 749222:NITSA_RS08410
uniprot id: E6X0X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

749222:NITSA RS09875
gene id: 749222:NITSA_RS09875
uniprot id: E6X2K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

749222:NITSA RS07140
gene id: 749222:NITSA_RS07140
uniprot id: E6WZL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

749222:NITSA RS10270
gene id: 749222:NITSA_RS10270
uniprot id: E6X2Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

749222:NITSA RS06365
gene id: 749222:NITSA_RS06365
uniprot id: E6WYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

749222:NITSA RS01920
gene id: 749222:NITSA_RS01920
uniprot id: E6WZY7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS04925
gene id: 749222:NITSA_RS04925
uniprot id: E6X3E9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

749222:NITSA RS05695
gene id: 749222:NITSA_RS05695
uniprot id: E6WXZ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS02530
gene id: 749222:NITSA_RS02530
uniprot id: E6X0P5
names: Subcellular Location Annotation
messages: Periplasm

749222:NITSA RS04575
gene id: 749222:NITSA_RS04575
uniprot id: E6X316
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

749222:NITSA RS10530
gene id: 749222:NITSA_RS10530
uniprot id: E6X3B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

749222:NITSA RS01390
gene id: 749222:NITSA_RS01390
uniprot id: E6WZG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

749222:NITSA RS07010
gene id: 749222:NITSA_RS07010
uniprot id: E6WZC3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

749222:NITSA RS00080
gene id: 749222:NITSA_RS00080
uniprot id: E6WXW9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

749222:NITSA RS01245
gene id: 749222:NITSA_RS01245
uniprot id: E6WZ63
names: Similarity
messages: Belongs to the UPF0047 family.

749222:NITSA RS05030
gene id: 749222:NITSA_RS05030
uniprot id: E6X3H0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

749222:NITSA RS05745
gene id: 749222:NITSA_RS05745
uniprot id: E6WY10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PagL family.
messages: Cell outer membrane
messages: Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety.
messages: Homodimer.

749222:NITSA RS05575
gene id: 749222:NITSA_RS05575
uniprot id: E6WXU5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

749222:NITSA RS08015
gene id: 749222:NITSA_RS08015
uniprot id: E6X0I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

749222:NITSA RS09360
gene id: 749222:NITSA_RS09360
uniprot id: E6X232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

749222:NITSA RS04795
gene id: 749222:NITSA_RS04795
uniprot id: E6X356
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

749222:NITSA RS03895
gene id: 749222:NITSA_RS03895
uniprot id: E6X298
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

749222:NITSA RS01675
gene id: 749222:NITSA_RS01675
uniprot id: E6WZU0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

749222:NITSA RS00795
gene id: 749222:NITSA_RS00795
uniprot id: E6WYQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

749222:NITSA RS03505
gene id: 749222:NITSA_RS03505
uniprot id: E6X1U9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS02695
gene id: 749222:NITSA_RS02695
uniprot id: E6X0S8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

749222:NITSA RS05355
gene id: 749222:NITSA_RS05355
uniprot id: E6WXQ2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

749222:NITSA RS00565
gene id: 749222:NITSA_RS00565
uniprot id: E6WYK7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

749222:NITSA RS08545
gene id: 749222:NITSA_RS08545
uniprot id: E6X169
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

749222:NITSA RS10520
gene id: 749222:NITSA_RS10520
uniprot id: E6X3B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS03695
gene id: 749222:NITSA_RS03695
uniprot id: E6X1Y7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

749222:NITSA RS00055
gene id: 749222:NITSA_RS00055
uniprot id: E6WXW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

749222:NITSA RS07280
gene id: 749222:NITSA_RS07280
uniprot id: E6WZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

749222:NITSA RS09320
gene id: 749222:NITSA_RS09320
uniprot id: E6X224
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS05420
gene id: 749222:NITSA_RS05420
uniprot id: E6WXR4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS01200
gene id: 749222:NITSA_RS01200
uniprot id: E6WZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

749222:NITSA RS01575
gene id: 749222:NITSA_RS01575
uniprot id: E6WZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS01950
gene id: 749222:NITSA_RS01950
uniprot id: E6WZZ3
names: Similarity
messages: Belongs to the DprA/Smf family.

749222:NITSA RS05765
gene id: 749222:NITSA_RS05765
uniprot id: E6WY14
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

749222:NITSA RS00895
gene id: 749222:NITSA_RS00895
uniprot id: E6WYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

749222:NITSA RS03770
gene id: 749222:NITSA_RS03770
uniprot id: E6X201
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

749222:NITSA RS06675
gene id: 749222:NITSA_RS06675
uniprot id: E6WYY1
names: Similarity
messages: Belongs to the YggT family.

749222:NITSA RS05860
gene id: 749222:NITSA_RS05860
uniprot id: E6WY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

749222:NITSA RS05465
gene id: 749222:NITSA_RS05465
uniprot id: E6WXS2
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

749222:NITSA RS10700
gene id: 749222:NITSA_RS10700
uniprot id: E6X3L9
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

749222:NITSA RS10660
gene id: 749222:NITSA_RS10660
uniprot id: E6X3D7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS08800
gene id: 749222:NITSA_RS08800
uniprot id: E6X1C1
names: Similarity
messages: Belongs to the DEAD box helicase family.

749222:NITSA RS03025
gene id: 749222:NITSA_RS03025
uniprot id: E6X160
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

749222:NITSA RS00120
gene id: 749222:NITSA_RS00120
uniprot id: E6WXX7
names: Similarity
messages: Belongs to the FeoA family.

749222:NITSA RS01010
gene id: 749222:NITSA_RS01010
uniprot id: E6WZ15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

749222:NITSA RS03010
gene id: 749222:NITSA_RS03010
uniprot id: E6X157
names: Similarity
messages: Belongs to the CvfB family.

749222:NITSA RS00660
gene id: 749222:NITSA_RS00660
uniprot id: E6WYM6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

749222:NITSA RS07880
gene id: 749222:NITSA_RS07880
uniprot id: E6X0F4
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

749222:NITSA RS03000
gene id: 749222:NITSA_RS03000
uniprot id: E6X155
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

749222:NITSA RS06965
gene id: 749222:NITSA_RS06965
uniprot id: E6WZB4
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

749222:NITSA RS05795
gene id: 749222:NITSA_RS05795
uniprot id: E6WY20
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

749222:NITSA RS02965
gene id: 749222:NITSA_RS02965
uniprot id: E6X148
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

749222:NITSA RS07800
gene id: 749222:NITSA_RS07800
uniprot id: E6X065
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

749222:NITSA RS01965
gene id: 749222:NITSA_RS01965
uniprot id: E6WZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

749222:NITSA RS06490
gene id: 749222:NITSA_RS06490
uniprot id: E6WYU8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

749222:NITSA RS06910
gene id: 749222:NITSA_RS06910
uniprot id: E6WZA2
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

749222:NITSA RS06185
gene id: 749222:NITSA_RS06185
uniprot id: E6WYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

749222:NITSA RS10170
gene id: 749222:NITSA_RS10170
uniprot id: E6X2X8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

749222:NITSA RS10585
gene id: 749222:NITSA_RS10585
uniprot id: E6X3C7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00970
gene id: 749222:NITSA_RS00970
uniprot id: E6WZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

749222:NITSA RS02185
gene id: 749222:NITSA_RS02185
uniprot id: E6X0A9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

749222:NITSA RS04385
gene id: 749222:NITSA_RS04385
uniprot id: E6X2Q6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

749222:NITSA RS10775
gene id: 749222:NITSA_RS10775
uniprot id: E6X1G6
names: Similarity
messages: Belongs to the peptidase C40 family.

749222:NITSA RS06530
gene id: 749222:NITSA_RS06530
uniprot id: E6WYV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

749222:NITSA RS07565
gene id: 749222:NITSA_RS07565
uniprot id: E6X018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

749222:NITSA RS00350
gene id: 749222:NITSA_RS00350
uniprot id: E6WY92
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

749222:NITSA RS06915
gene id: 749222:NITSA_RS06915
uniprot id: E6WZA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

749222:NITSA RS00945
gene id: 749222:NITSA_RS00945
uniprot id: E6WZ02
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS00690
gene id: 749222:NITSA_RS00690
uniprot id: E6WYN1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

749222:NITSA RS01840
gene id: 749222:NITSA_RS01840
uniprot id: E6WZX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

749222:NITSA RS09600
gene id: 749222:NITSA_RS09600
uniprot id: E6X2E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

749222:NITSA RS06620
gene id: 749222:NITSA_RS06620
uniprot id: E6WYX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

749222:NITSA RS03360
gene id: 749222:NITSA_RS03360
uniprot id: E6X1J6
names: Similarity
messages: Belongs to the UPF0102 family.

749222:NITSA RS10125
gene id: 749222:NITSA_RS10125
uniprot id: E6X2W9
names: Similarity
messages: Belongs to the peptidase S13 family.

749222:NITSA RS04325
gene id: 749222:NITSA_RS04325
uniprot id: E6X2P4
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

749222:NITSA RS01055
gene id: 749222:NITSA_RS01055
uniprot id: E6WZ24
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

749222:NITSA RS10105
gene id: 749222:NITSA_RS10105
uniprot id: E6X2W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

749222:NITSA RS07000
gene id: 749222:NITSA_RS07000
uniprot id: E6WZC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

749222:NITSA RS07740
gene id: 749222:NITSA_RS07740
uniprot id: E6X053
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

749222:NITSA RS08310
gene id: 749222:NITSA_RS08310
uniprot id: E6X0W0
names: Similarity
messages: Belongs to the TlyA family.

749222:NITSA RS05375
gene id: 749222:NITSA_RS05375
uniprot id: E6WXQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

749222:NITSA RS02600
gene id: 749222:NITSA_RS02600
uniprot id: E6X0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

749222:NITSA RS01175
gene id: 749222:NITSA_RS01175
uniprot id: E6WZ49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

749222:NITSA RS07735
gene id: 749222:NITSA_RS07735
uniprot id: E6X052
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS08635
gene id: 749222:NITSA_RS08635
uniprot id: E6X187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

749222:NITSA RS07940
gene id: 749222:NITSA_RS07940
uniprot id: E6X0G8
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

749222:NITSA RS06445
gene id: 749222:NITSA_RS06445
uniprot id: E6WYT9
names: Similarity
messages: Belongs to the peptidase C59 family.

749222:NITSA RS01240
gene id: 749222:NITSA_RS01240
uniprot id: E6WZ62
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

749222:NITSA RS01705
gene id: 749222:NITSA_RS01705
uniprot id: E6WZU6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

749222:NITSA RS02365
gene id: 749222:NITSA_RS02365
uniprot id: E6X0L3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

749222:NITSA RS06790
gene id: 749222:NITSA_RS06790
uniprot id: E6WZ78
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00675
gene id: 749222:NITSA_RS00675
uniprot id: E6WYM8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS05660
gene id: 749222:NITSA_RS05660
uniprot id: E6WXZ2
names: Subcellular Location Annotation
messages: Cell outer membrane

749222:NITSA RS08115
gene id: 749222:NITSA_RS08115
uniprot id: E6X0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Periplasm

749222:NITSA RS06630
gene id: 749222:NITSA_RS06630
uniprot id: E6WYX2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00445
gene id: 749222:NITSA_RS00445
uniprot id: E6WYB1
names: Similarity
messages: Belongs to the HupF/HypC family.

749222:NITSA RS01550
gene id: 749222:NITSA_RS01550
uniprot id: E6WZJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

749222:NITSA RS08200
gene id: 749222:NITSA_RS08200
uniprot id: E6X0T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

749222:NITSA RS01560
gene id: 749222:NITSA_RS01560
uniprot id: E6WZJ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

749222:NITSA RS10150
gene id: 749222:NITSA_RS10150
uniprot id: E6X2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Membrane

749222:NITSA RS08835
gene id: 749222:NITSA_RS08835
uniprot id: E6X1C8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

749222:NITSA RS05295
gene id: 749222:NITSA_RS05295
uniprot id: E6WXP2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

749222:NITSA RS10110
gene id: 749222:NITSA_RS10110
uniprot id: E6X2W6
names: Subcellular Location Annotation
messages: Cytoplasm

749222:NITSA RS00020
gene id: 749222:NITSA_RS00020
uniprot id: E6WXV7
names: Similarity
messages: Belongs to the RecJ family.

749222:NITSA RS07830
gene id: 749222:NITSA_RS07830
uniprot id: E6X0E4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

749222:NITSA RS09755
gene id: 749222:NITSA_RS09755
uniprot id: E6X2H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Cell wall formation.
messages: Cytoplasm

749222:NITSA RS02420
gene id: 749222:NITSA_RS02420
uniprot id: E6X0M4
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

749222:NITSA RS06590
gene id: 749222:NITSA_RS06590
uniprot id: E6WYW4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

749222:NITSA RS05135
gene id: 749222:NITSA_RS05135
uniprot id: E6X3J0
names: Subcellular Location Annotation
messages: Cytoplasm

749222:NITSA RS00035
gene id: 749222:NITSA_RS00035
uniprot id: E6WXW0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

749222:NITSA RS08240
gene id: 749222:NITSA_RS08240
uniprot id: E6X0U6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07935
gene id: 749222:NITSA_RS07935
uniprot id: E6X0G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

749222:NITSA RS03545
gene id: 749222:NITSA_RS03545
uniprot id: E6X1V7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

749222:NITSA RS05220
gene id: 749222:NITSA_RS05220
uniprot id: E6X3K7
names: Similarity
messages: Belongs to the UbiD family.

749222:NITSA RS09315
gene id: 749222:NITSA_RS09315
uniprot id: E6X223
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07395
gene id: 749222:NITSA_RS07395
uniprot id: E6WZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

749222:NITSA RS03295
gene id: 749222:NITSA_RS03295
uniprot id: E6X1I3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

749222:NITSA RS00605
gene id: 749222:NITSA_RS00605
uniprot id: E6WYL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

749222:NITSA RS00875
gene id: 749222:NITSA_RS00875
uniprot id: E6WYR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS10570
gene id: 749222:NITSA_RS10570
uniprot id: E6X3C4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03005
gene id: 749222:NITSA_RS03005
uniprot id: E6X156
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

749222:NITSA RS02330
gene id: 749222:NITSA_RS02330
uniprot id: E6X0D8
names: Similarity
messages: Belongs to the GARS family.

749222:NITSA RS08570
gene id: 749222:NITSA_RS08570
uniprot id: E6X174
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

749222:NITSA RS04850
gene id: 749222:NITSA_RS04850
uniprot id: E6X367
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03315
gene id: 749222:NITSA_RS03315
uniprot id: E6X1I7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

749222:NITSA RS09450
gene id: 749222:NITSA_RS09450
uniprot id: E6X250
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

749222:NITSA RS00540
gene id: 749222:NITSA_RS00540
uniprot id: E6WYK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

749222:NITSA RS03095
gene id: 749222:NITSA_RS03095
uniprot id: E6X1E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

749222:NITSA RS06545
gene id: 749222:NITSA_RS06545
uniprot id: E6WYV8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

749222:NITSA RS00900
gene id: 749222:NITSA_RS00900
uniprot id: E6WYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS07020
gene id: 749222:NITSA_RS07020
uniprot id: E6WZC4
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07125
gene id: 749222:NITSA_RS07125
uniprot id: E6WZL3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

749222:NITSA RS02125
gene id: 749222:NITSA_RS02125
uniprot id: E6X097
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

749222:NITSA RS07210
gene id: 749222:NITSA_RS07210
uniprot id: E6WZN0
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00870
gene id: 749222:NITSA_RS00870
uniprot id: E6WYR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

749222:NITSA RS03375
gene id: 749222:NITSA_RS03375
uniprot id: E6X1J9
names: Similarity
messages: Belongs to the thioredoxin family.

749222:NITSA RS02770
gene id: 749222:NITSA_RS02770
uniprot id: E6X110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

749222:NITSA RS10080
gene id: 749222:NITSA_RS10080
uniprot id: E6X2W0
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

749222:NITSA RS04355
gene id: 749222:NITSA_RS04355
uniprot id: E6X2Q0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03205
gene id: 749222:NITSA_RS03205
uniprot id: E6X1G3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

749222:NITSA RS07955
gene id: 749222:NITSA_RS07955
uniprot id: E6X0H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

749222:NITSA RS07425
gene id: 749222:NITSA_RS07425
uniprot id: E6WZS2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

749222:NITSA RS07305
gene id: 749222:NITSA_RS07305
uniprot id: E6WZP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

749222:NITSA RS01485
gene id: 749222:NITSA_RS01485
uniprot id: E6WZI0
names: Similarity
messages: Belongs to the GSP E family.

749222:NITSA RS06655
gene id: 749222:NITSA_RS06655
uniprot id: E6WYX7
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

749222:NITSA RS02400
gene id: 749222:NITSA_RS02400
uniprot id: E6X0M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

749222:NITSA RS09355
gene id: 749222:NITSA_RS09355
uniprot id: E6X231
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

749222:NITSA RS05785
gene id: 749222:NITSA_RS05785
uniprot id: E6WY18
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

749222:NITSA RS06050
gene id: 749222:NITSA_RS06050
uniprot id: E6WYD3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03485
gene id: 749222:NITSA_RS03485
uniprot id: E6X1U5
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

749222:NITSA RS04155
gene id: 749222:NITSA_RS04155
uniprot id: E6X2L2
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS01700
gene id: 749222:NITSA_RS01700
uniprot id: E6WZU5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

749222:NITSA RS04465
gene id: 749222:NITSA_RS04465
uniprot id: E6X2S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

749222:NITSA RS08650
gene id: 749222:NITSA_RS08650
uniprot id: E6X190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

749222:NITSA RS04025
gene id: 749222:NITSA_RS04025
uniprot id: E6X2B8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

749222:NITSA RS02295
gene id: 749222:NITSA_RS02295
uniprot id: E6X0D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

749222:NITSA RS04295
gene id: 749222:NITSA_RS04295
uniprot id: E6X2N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

749222:NITSA RS00125
gene id: 749222:NITSA_RS00125
uniprot id: E6WXX8
names: Similarity
messages: Belongs to the YkuD family.

749222:NITSA RS04880
gene id: 749222:NITSA_RS04880
uniprot id: E6X373
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

749222:NITSA RS02895
gene id: 749222:NITSA_RS02895
uniprot id: E6X134
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS00810
gene id: 749222:NITSA_RS00810
uniprot id: E6WYQ5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

749222:NITSA RS02500
gene id: 749222:NITSA_RS02500
uniprot id: E6X0N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

749222:NITSA RS10075
gene id: 749222:NITSA_RS10075
uniprot id: E6X2V9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

749222:NITSA RS07985
gene id: 749222:NITSA_RS07985
uniprot id: E6X0H7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS06390
gene id: 749222:NITSA_RS06390
uniprot id: E6WYS9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

749222:NITSA RS09170
gene id: 749222:NITSA_RS09170
uniprot id: E6X1S1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

749222:NITSA RS03655
gene id: 749222:NITSA_RS03655
uniprot id: E6X1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

749222:NITSA RS01830
gene id: 749222:NITSA_RS01830
uniprot id: E6WZW9
names: Similarity
messages: Belongs to the class-I fumarase family.

749222:NITSA RS00580
gene id: 749222:NITSA_RS00580
uniprot id: E6WYL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

749222:NITSA RS00390
gene id: 749222:NITSA_RS00390
uniprot id: E6WYA0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

749222:NITSA RS06825
gene id: 749222:NITSA_RS06825
uniprot id: E6WZ85
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

749222:NITSA RS02675
gene id: 749222:NITSA_RS02675
uniprot id: E6X0S4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

749222:NITSA RS10015
gene id: 749222:NITSA_RS10015
uniprot id: E6X2U8
names: Similarity
messages: Belongs to the polysaccharide synthase family.

749222:NITSA RS07755
gene id: 749222:NITSA_RS07755
uniprot id: E6X056
names: Similarity
messages: Belongs to the thioredoxin family.

749222:NITSA RS00400
gene id: 749222:NITSA_RS00400
uniprot id: E6WYA2
names: Similarity
messages: Belongs to the peptidase A31 family.

749222:NITSA RS02715
gene id: 749222:NITSA_RS02715
uniprot id: E6X0Z9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

749222:NITSA RS00530
gene id: 749222:NITSA_RS00530
uniprot id: E6WYK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

749222:NITSA RS02025
gene id: 749222:NITSA_RS02025
uniprot id: E6X077
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

749222:NITSA RS03610
gene id: 749222:NITSA_RS03610
uniprot id: E6X1X0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

749222:NITSA RS10475
gene id: 749222:NITSA_RS10475
uniprot id: E6X3A5
names: Similarity
messages: Belongs to the YkuD family.

749222:NITSA RS04600
gene id: 749222:NITSA_RS04600
uniprot id: E6X321
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS10555
gene id: 749222:NITSA_RS10555
uniprot id: E6X3C1
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS09895
gene id: 749222:NITSA_RS09895
uniprot id: E6X2K6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

749222:NITSA RS04090
gene id: 749222:NITSA_RS04090
uniprot id: E6X2D1
names: Similarity
messages: Belongs to the TrpC family.

749222:NITSA RS09475
gene id: 749222:NITSA_RS09475
uniprot id: E6X255
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS04430
gene id: 749222:NITSA_RS04430
uniprot id: E6X2R5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

749222:NITSA RS09560
gene id: 749222:NITSA_RS09560
uniprot id: E6X272
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

749222:NITSA RS00330
gene id: 749222:NITSA_RS00330
uniprot id: E6WY87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

749222:NITSA RS10215
gene id: 749222:NITSA_RS10215
uniprot id: E6X2Y6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

749222:NITSA RS04670
gene id: 749222:NITSA_RS04670
uniprot id: E6X333
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

749222:NITSA RS04755
gene id: 749222:NITSA_RS04755
uniprot id: E6X348
names: Similarity
messages: Belongs to the Nth/MutY family.

749222:NITSA RS02180
gene id: 749222:NITSA_RS02180
uniprot id: E6X0A8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

749222:NITSA RS10500
gene id: 749222:NITSA_RS10500
uniprot id: E6X3B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

749222:NITSA RS04975
gene id: 749222:NITSA_RS04975
uniprot id: E6X3F9
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS04895
gene id: 749222:NITSA_RS04895
uniprot id: E6X3E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

749222:NITSA RS09770
gene id: 749222:NITSA_RS09770
uniprot id: E6X2I1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

749222:NITSA RS10540
gene id: 749222:NITSA_RS10540
uniprot id: E6X3B8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

749222:NITSA RS03325
gene id: 749222:NITSA_RS03325
uniprot id: E6X1I9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

749222:NITSA RS00545
gene id: 749222:NITSA_RS00545
uniprot id: E6WYK3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

749222:NITSA RS01480
gene id: 749222:NITSA_RS01480
uniprot id: E6WZH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

749222:NITSA RS01710
gene id: 749222:NITSA_RS01710
uniprot id: E6WZU7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

749222:NITSA RS02775
gene id: 749222:NITSA_RS02775
uniprot id: E6X111
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

749222:NITSA RS07845
gene id: 749222:NITSA_RS07845
uniprot id: E6X0E7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

749222:NITSA RS00145
gene id: 749222:NITSA_RS00145
uniprot id: E6WXY2
names: Similarity
messages: Belongs to the nitroreductase family.

749222:NITSA RS02255
gene id: 749222:NITSA_RS02255
uniprot id: E6X0C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

749222:NITSA RS10435
gene id: 749222:NITSA_RS10435
uniprot id: E6X398
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

749222:NITSA RS02495
gene id: 749222:NITSA_RS02495
uniprot id: E6X0N8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

749222:NITSA RS07135
gene id: 749222:NITSA_RS07135
uniprot id: E6WZL5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

749222:NITSA RS01500
gene id: 749222:NITSA_RS01500
uniprot id: E6WZI3
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS01610
gene id: 749222:NITSA_RS01610
uniprot id: E6WZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

749222:NITSA RS03685
gene id: 749222:NITSA_RS03685
uniprot id: E6X1Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

749222:NITSA RS00620
gene id: 749222:NITSA_RS00620
uniprot id: E6WYL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

749222:NITSA RS04515
gene id: 749222:NITSA_RS04515
uniprot id: E6X2T2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

749222:NITSA RS06600
gene id: 749222:NITSA_RS06600
uniprot id: E6WYW6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS09890
gene id: 749222:NITSA_RS09890
uniprot id: E6X2K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

749222:NITSA RS06970
gene id: 749222:NITSA_RS06970
uniprot id: E6WZB5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

749222:NITSA RS05655
gene id: 749222:NITSA_RS05655
uniprot id: E6WXZ1
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS03575
gene id: 749222:NITSA_RS03575
uniprot id: E6X1W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

749222:NITSA RS05615
gene id: 749222:NITSA_RS05615
uniprot id: E6WXV0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

749222:NITSA RS09915
gene id: 749222:NITSA_RS09915
uniprot id: E6X2L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

749222:NITSA RS01515
gene id: 749222:NITSA_RS01515
uniprot id: E6WZI6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

749222:NITSA RS10205
gene id: 749222:NITSA_RS10205
uniprot id: E6X2Y4
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS04490
gene id: 749222:NITSA_RS04490
uniprot id: E6X2S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

749222:NITSA RS07355
gene id: 749222:NITSA_RS07355
uniprot id: E6WZQ9
names: Similarity
messages: Belongs to the glutamate synthase family.

749222:NITSA RS03665
gene id: 749222:NITSA_RS03665
uniprot id: E6X1Y1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

749222:NITSA RS06940
gene id: 749222:NITSA_RS06940
uniprot id: E6WZA9
names: Similarity
messages: Belongs to the class II ribonucleoside-triphosphate reductase family.

749222:NITSA RS10040
gene id: 749222:NITSA_RS10040
uniprot id: E6X2V3
names: Similarity
messages: Belongs to the stealth family.

749222:NITSA RS09860
gene id: 749222:NITSA_RS09860
uniprot id: E6X2J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

749222:NITSA RS08565
gene id: 749222:NITSA_RS08565
uniprot id: E6X173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

749222:NITSA RS00010
gene id: 749222:NITSA_RS00010
uniprot id: E6WXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

749222:NITSA RS09520
gene id: 749222:NITSA_RS09520
uniprot id: E6X264
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

749222:NITSA RS08255
gene id: 749222:NITSA_RS08255
uniprot id: E6X0U9
names: Similarity
messages: Belongs to the UPF0178 family.

749222:NITSA RS03300
gene id: 749222:NITSA_RS03300
uniprot id: E6X1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

749222:NITSA RS06950
gene id: 749222:NITSA_RS06950
uniprot id: E6WZB1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

749222:NITSA RS02670
gene id: 749222:NITSA_RS02670
uniprot id: E6X0S3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

749222:NITSA RS01025
gene id: 749222:NITSA_RS01025
uniprot id: E6WZ18
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS07650
gene id: 749222:NITSA_RS07650
uniprot id: E6X035
names: Similarity
messages: Belongs to the SAICAR synthetase family.

749222:NITSA RS02190
gene id: 749222:NITSA_RS02190
uniprot id: E6X0B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

749222:NITSA RS00570
gene id: 749222:NITSA_RS00570
uniprot id: E6WYK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

749222:NITSA RS05125
gene id: 749222:NITSA_RS05125
uniprot id: E6X3I8
names: Similarity
messages: Belongs to the GPI family.

749222:NITSA RS05645
gene id: 749222:NITSA_RS05645
uniprot id: E6WXY9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

749222:NITSA RS02280
gene id: 749222:NITSA_RS02280
uniprot id: E6X0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

749222:NITSA RS03590
gene id: 749222:NITSA_RS03590
uniprot id: E6X1W6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

749222:NITSA RS08425
gene id: 749222:NITSA_RS08425
uniprot id: E6X0Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS05225
gene id: 749222:NITSA_RS05225
uniprot id: E6X3K8
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

749222:NITSA RS06395
gene id: 749222:NITSA_RS06395
uniprot id: E6WYT0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

749222:NITSA RS04390
gene id: 749222:NITSA_RS04390
uniprot id: E6X2Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS02215
gene id: 749222:NITSA_RS02215
uniprot id: E6X0B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

749222:NITSA RS04085
gene id: 749222:NITSA_RS04085
uniprot id: E6X2D0
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS10480
gene id: 749222:NITSA_RS10480
uniprot id: E6X3A6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

749222:NITSA RS00090
gene id: 749222:NITSA_RS00090
uniprot id: E6WXX1
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS05320
gene id: 749222:NITSA_RS05320
uniprot id: E6WXP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

749222:NITSA RS01810
gene id: 749222:NITSA_RS01810
uniprot id: E6WZW5
names: Similarity
messages: Belongs to the ArsC family.

749222:NITSA RS06170
gene id: 749222:NITSA_RS06170
uniprot id: E6WYF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

749222:NITSA RS07225
gene id: 749222:NITSA_RS07225
uniprot id: E6WZN3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

749222:NITSA RS02490
gene id: 749222:NITSA_RS02490
uniprot id: E6X0N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS00005
gene id: 749222:NITSA_RS00005
uniprot id: E6WXV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

749222:NITSA RS07130
gene id: 749222:NITSA_RS07130
uniprot id: E6WZL4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

749222:NITSA RS06320
gene id: 749222:NITSA_RS06320
uniprot id: E6WYI9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

749222:NITSA RS05775
gene id: 749222:NITSA_RS05775
uniprot id: E6WY16
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

749222:NITSA RS03285
gene id: 749222:NITSA_RS03285
uniprot id: E6X1I1
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS04480
gene id: 749222:NITSA_RS04480
uniprot id: E6X2S5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS06270
gene id: 749222:NITSA_RS06270
uniprot id: E6WYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

749222:NITSA RS04580
gene id: 749222:NITSA_RS04580
uniprot id: E6X317
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS07670
gene id: 749222:NITSA_RS07670
uniprot id: E6X039
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

749222:NITSA RS10705
gene id: 749222:NITSA_RS10705
uniprot id: E6X3M0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS01265
gene id: 749222:NITSA_RS01265
uniprot id: E6WZ67
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS02230
gene id: 749222:NITSA_RS02230
uniprot id: E6X0B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

749222:NITSA RS00575
gene id: 749222:NITSA_RS00575
uniprot id: E6WYK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

749222:NITSA RS02290
gene id: 749222:NITSA_RS02290
uniprot id: E6X0D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS09660
gene id: 749222:NITSA_RS09660
uniprot id: E6X2F7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

749222:NITSA RS08555
gene id: 749222:NITSA_RS08555
uniprot id: E6X171
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

749222:NITSA RS05045
gene id: 749222:NITSA_RS05045
uniprot id: E6X3H3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

749222:NITSA RS01685
gene id: 749222:NITSA_RS01685
uniprot id: E6WZU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS05105
gene id: 749222:NITSA_RS05105
uniprot id: E6X3I4
names: Function
names: Similarity
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

749222:NITSA RS01875
gene id: 749222:NITSA_RS01875
uniprot id: E6WZX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

749222:NITSA RS05610
gene id: 749222:NITSA_RS05610
uniprot id: E6WXU9
names: Similarity
messages: Belongs to the IMPACT family.

749222:NITSA RS07620
gene id: 749222:NITSA_RS07620
uniprot id: E6X029
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

749222:NITSA RS07155
gene id: 749222:NITSA_RS07155
uniprot id: E6WZL9
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07150
gene id: 749222:NITSA_RS07150
uniprot id: E6WZL8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

749222:NITSA RS03500
gene id: 749222:NITSA_RS03500
uniprot id: E6X1U8
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

749222:NITSA RS02955
gene id: 749222:NITSA_RS02955
uniprot id: E6X146
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS04335
gene id: 749222:NITSA_RS04335
uniprot id: E6X2P6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

749222:NITSA RS01935
gene id: 749222:NITSA_RS01935
uniprot id: E6WZZ0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS03540
gene id: 749222:NITSA_RS03540
uniprot id: E6X1V6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

749222:NITSA RS09535
gene id: 749222:NITSA_RS09535
uniprot id: E6X266
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

749222:NITSA RS04015
gene id: 749222:NITSA_RS04015
uniprot id: E6X2B6
names: Similarity
messages: Belongs to the peptidase C40 family.

749222:NITSA RS06335
gene id: 749222:NITSA_RS06335
uniprot id: E6WYJ3
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

749222:NITSA RS07090
gene id: 749222:NITSA_RS07090
uniprot id: E6WZD7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00225
gene id: 749222:NITSA_RS00225
uniprot id: E6WY66
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

749222:NITSA RS06980
gene id: 749222:NITSA_RS06980
uniprot id: E6WZB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

749222:NITSA RS05830
gene id: 749222:NITSA_RS05830
uniprot id: E6WY27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

749222:NITSA RS09225
gene id: 749222:NITSA_RS09225
uniprot id: E6X1T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

749222:NITSA RS09550
gene id: 749222:NITSA_RS09550
uniprot id: E6X270
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

749222:NITSA RS01340
gene id: 749222:NITSA_RS01340
uniprot id: E6WZF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

749222:NITSA RS10265
gene id: 749222:NITSA_RS10265
uniprot id: E6X2Z6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

749222:NITSA RS08435
gene id: 749222:NITSA_RS08435
uniprot id: E6X0Y4
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

749222:NITSA RS03445
gene id: 749222:NITSA_RS03445
uniprot id: E6X1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

749222:NITSA RS06540
gene id: 749222:NITSA_RS06540
uniprot id: E6WYV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

749222:NITSA RS02175
gene id: 749222:NITSA_RS02175
uniprot id: E6X0A7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

749222:NITSA RS04610
gene id: 749222:NITSA_RS04610
uniprot id: E6X323
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

749222:NITSA RS09815
gene id: 749222:NITSA_RS09815
uniprot id: E6X2J0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

749222:NITSA RS00520
gene id: 749222:NITSA_RS00520
uniprot id: E6WYC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

749222:NITSA RS06955
gene id: 749222:NITSA_RS06955
uniprot id: E6WZB2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

749222:NITSA RS03165
gene id: 749222:NITSA_RS03165
uniprot id: E6X1F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS07625
gene id: 749222:NITSA_RS07625
uniprot id: E6X030
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

749222:NITSA RS10655
gene id: 749222:NITSA_RS10655
uniprot id: E6X3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

749222:NITSA RS08845
gene id: 749222:NITSA_RS08845
uniprot id: E6X1D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

749222:NITSA RS09555
gene id: 749222:NITSA_RS09555
uniprot id: E6X271
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

749222:NITSA RS08020
gene id: 749222:NITSA_RS08020
uniprot id: E6X0I4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

749222:NITSA RS06210
gene id: 749222:NITSA_RS06210
uniprot id: E6WYG6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

749222:NITSA RS10325
gene id: 749222:NITSA_RS10325
uniprot id: E6X378
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

749222:NITSA RS07730
gene id: 749222:NITSA_RS07730
uniprot id: E6X051
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

749222:NITSA RS08770
gene id: 749222:NITSA_RS08770
uniprot id: E6X1B5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

749222:NITSA RS00745
gene id: 749222:NITSA_RS00745
uniprot id: E6WYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

749222:NITSA RS02335
gene id: 749222:NITSA_RS02335
uniprot id: E6X0D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03385
gene id: 749222:NITSA_RS03385
uniprot id: E6X1K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

749222:NITSA RS00725
gene id: 749222:NITSA_RS00725
uniprot id: E6WYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

749222:NITSA RS00655
gene id: 749222:NITSA_RS00655
uniprot id: E6WYM5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

749222:NITSA RS09945
gene id: 749222:NITSA_RS09945
uniprot id: E6X2T4
names: Similarity
messages: Belongs to the SUI1 family.

749222:NITSA RS02575
gene id: 749222:NITSA_RS02575
uniprot id: E6X0Q4
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS05490
gene id: 749222:NITSA_RS05490
uniprot id: E6WXS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

749222:NITSA RS07615
gene id: 749222:NITSA_RS07615
uniprot id: E6X028
names: Similarity
messages: Belongs to the ClpX chaperone family. HslU subfamily.

749222:NITSA RS09610
gene id: 749222:NITSA_RS09610
uniprot id: E6X2E7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS03605
gene id: 749222:NITSA_RS03605
uniprot id: E6X1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

749222:NITSA RS00640
gene id: 749222:NITSA_RS00640
uniprot id: E6WYM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

749222:NITSA RS05705
gene id: 749222:NITSA_RS05705
uniprot id: E6WY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS02880
gene id: 749222:NITSA_RS02880
uniprot id: E6X131
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

749222:NITSA RS00230
gene id: 749222:NITSA_RS00230
uniprot id: E6WY67
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

749222:NITSA RS01975
gene id: 749222:NITSA_RS01975
uniprot id: E6WZZ8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

749222:NITSA RS02020
gene id: 749222:NITSA_RS02020
uniprot id: E6X076
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

749222:NITSA RS00645
gene id: 749222:NITSA_RS00645
uniprot id: E6WYM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

749222:NITSA RS00315
gene id: 749222:NITSA_RS00315
uniprot id: E6WY84
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

749222:NITSA RS05995
gene id: 749222:NITSA_RS05995
uniprot id: E6WY59
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

749222:NITSA RS09575
gene id: 749222:NITSA_RS09575
uniprot id: E6X276
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

749222:NITSA RS08685
gene id: 749222:NITSA_RS08685
uniprot id: E6X197
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

749222:NITSA RS09445
gene id: 749222:NITSA_RS09445
uniprot id: E6X249
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

749222:NITSA RS03135
gene id: 749222:NITSA_RS03135
uniprot id: E6X1F2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS09330
gene id: 749222:NITSA_RS09330
uniprot id: E6X226
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

749222:NITSA RS09635
gene id: 749222:NITSA_RS09635
uniprot id: E6X2F2
names: Similarity
messages: Belongs to the pyruvate kinase family.

749222:NITSA RS03390
gene id: 749222:NITSA_RS03390
uniprot id: E6X1K2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00765
gene id: 749222:NITSA_RS00765
uniprot id: E6WYP6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

749222:NITSA RS03280
gene id: 749222:NITSA_RS03280
uniprot id: E6X1I0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

749222:NITSA RS08315
gene id: 749222:NITSA_RS08315
uniprot id: E6X0W1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

749222:NITSA RS05260
gene id: 749222:NITSA_RS05260
uniprot id: E6X3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS01315
gene id: 749222:NITSA_RS01315
uniprot id: E6WZE7
names: Similarity
messages: Belongs to the peptidase S8 family.

749222:NITSA RS07200
gene id: 749222:NITSA_RS07200
uniprot id: E6WZM8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

749222:NITSA RS02035
gene id: 749222:NITSA_RS02035
uniprot id: E6X079
names: Similarity
messages: Belongs to the threonine synthase family.

749222:NITSA RS09750
gene id: 749222:NITSA_RS09750
uniprot id: E6X2H7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

749222:NITSA RS04055
gene id: 749222:NITSA_RS04055
uniprot id: E6X2C4
names: Similarity
messages: Belongs to the fabD family.

749222:NITSA RS00475
gene id: 749222:NITSA_RS00475
uniprot id: E6WYB7
names: Similarity
messages: Belongs to the YkuD family.

749222:NITSA RS03320
gene id: 749222:NITSA_RS03320
uniprot id: E6X1I8
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

749222:NITSA RS07295
gene id: 749222:NITSA_RS07295
uniprot id: E6WZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS00215
gene id: 749222:NITSA_RS00215
uniprot id: E6WY64
names: Similarity
messages: Belongs to the peptidase C40 family.

749222:NITSA RS08390
gene id: 749222:NITSA_RS08390
uniprot id: E6X0X6
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.

749222:NITSA RS08465
gene id: 749222:NITSA_RS08465
uniprot id: E6X0Z0
names: Similarity
messages: Belongs to the peptidase M16 family.

749222:NITSA RS03840
gene id: 749222:NITSA_RS03840
uniprot id: E6X287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

749222:NITSA RS08130
gene id: 749222:NITSA_RS08130
uniprot id: E6X0K6
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

749222:NITSA RS09525
gene id: 749222:NITSA_RS09525
uniprot id: E6X265
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

749222:NITSA RS00045
gene id: 749222:NITSA_RS00045
uniprot id: E6WXW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

749222:NITSA RS00210
gene id: 749222:NITSA_RS00210
uniprot id: E6WY63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00395
gene id: 749222:NITSA_RS00395
uniprot id: E6WYA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

749222:NITSA RS06245
gene id: 749222:NITSA_RS06245
uniprot id: E6WYH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

749222:NITSA RS00965
gene id: 749222:NITSA_RS00965
uniprot id: E6WZ06
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS05360
gene id: 749222:NITSA_RS05360
uniprot id: E6WXQ3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

749222:NITSA RS10135
gene id: 749222:NITSA_RS10135
uniprot id: E6X2X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

749222:NITSA RS03985
gene id: 749222:NITSA_RS03985
uniprot id: E6X2B0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

749222:NITSA RS02735
gene id: 749222:NITSA_RS02735
uniprot id: E6X103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS06990
gene id: 749222:NITSA_RS06990
uniprot id: E6WZB9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

749222:NITSA RS03570
gene id: 749222:NITSA_RS03570
uniprot id: E6X1W2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

749222:NITSA RS04835
gene id: 749222:NITSA_RS04835
uniprot id: E6X364
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

749222:NITSA RS06515
gene id: 749222:NITSA_RS06515
uniprot id: E6WYV2
names: Similarity
messages: Belongs to the AAA ATPase family.

749222:NITSA RS07490
gene id: 749222:NITSA_RS07490
uniprot id: E6X003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).
messages: Membrane

749222:NITSA RS09675
gene id: 749222:NITSA_RS09675
uniprot id: E6X2G0
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

749222:NITSA RS02410
gene id: 749222:NITSA_RS02410
uniprot id: E6X0M2
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

749222:NITSA RS02445
gene id: 749222:NITSA_RS02445
uniprot id: E6X0M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

749222:NITSA RS03850
gene id: 749222:NITSA_RS03850
uniprot id: E6X289
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

749222:NITSA RS04790
gene id: 749222:NITSA_RS04790
uniprot id: E6X355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

749222:NITSA RS08780
gene id: 749222:NITSA_RS08780
uniprot id: E6X1B7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

749222:NITSA RS09990
gene id: 749222:NITSA_RS09990
uniprot id: E6X2U3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

749222:NITSA RS09845
gene id: 749222:NITSA_RS09845
uniprot id: E6X2J6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00155
gene id: 749222:NITSA_RS00155
uniprot id: E6WXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

749222:NITSA RS01445
gene id: 749222:NITSA_RS01445
uniprot id: E6WZH2
names: Subcellular Location Annotation
messages: Cell outer membrane

749222:NITSA RS08000
gene id: 749222:NITSA_RS08000
uniprot id: E6X0I0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

749222:NITSA RS08335
gene id: 749222:NITSA_RS08335
uniprot id: E6X0W5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

749222:NITSA RS06140
gene id: 749222:NITSA_RS06140
uniprot id: E6WYF2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

749222:NITSA RS04890
gene id: 749222:NITSA_RS04890
uniprot id: E6X3E2
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

749222:NITSA RS00755
gene id: 749222:NITSA_RS00755
uniprot id: E6WYP4
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS01725
gene id: 749222:NITSA_RS01725
uniprot id: E6WZV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

749222:NITSA RS01180
gene id: 749222:NITSA_RS01180
uniprot id: E6WZ50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

749222:NITSA RS08640
gene id: 749222:NITSA_RS08640
uniprot id: E6X188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

749222:NITSA RS04485
gene id: 749222:NITSA_RS04485
uniprot id: E6X2S6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS01465
gene id: 749222:NITSA_RS01465
uniprot id: E6WZH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

749222:NITSA RS02285
gene id: 749222:NITSA_RS02285
uniprot id: E6X0C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

749222:NITSA RS00115
gene id: 749222:NITSA_RS00115
uniprot id: E6WXX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

749222:NITSA RS09855
gene id: 749222:NITSA_RS09855
uniprot id: E6X2J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

749222:NITSA RS00535
gene id: 749222:NITSA_RS00535
uniprot id: E6WYK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

749222:NITSA RS00615
gene id: 749222:NITSA_RS00615
uniprot id: E6WYL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

749222:NITSA RS07640
gene id: 749222:NITSA_RS07640
uniprot id: E6X033
names: Similarity
messages: Belongs to the ClpA/ClpB family.

749222:NITSA RS03235
gene id: 749222:NITSA_RS03235
uniprot id: E6X1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

749222:NITSA RS02435
gene id: 749222:NITSA_RS02435
uniprot id: E6X0M7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

749222:NITSA RS01000
gene id: 749222:NITSA_RS01000
uniprot id: E6WZ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

749222:NITSA RS02055
gene id: 749222:NITSA_RS02055
uniprot id: E6X083
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

749222:NITSA RS03115
gene id: 749222:NITSA_RS03115
uniprot id: E6X1E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

749222:NITSA RS03245
gene id: 749222:NITSA_RS03245
uniprot id: E6X1H3
names: Similarity
messages: Belongs to the aspartokinase family.

749222:NITSA RS09780
gene id: 749222:NITSA_RS09780
uniprot id: E6X2I3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

749222:NITSA RS09380
gene id: 749222:NITSA_RS09380
uniprot id: E6X236
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

749222:NITSA RS10685
gene id: 749222:NITSA_RS10685
uniprot id: E6X3L6
names: Similarity
messages: Belongs to the UPF0045 family.

749222:NITSA RS01255
gene id: 749222:NITSA_RS01255
uniprot id: E6WZ65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

749222:NITSA RS05670
gene id: 749222:NITSA_RS05670
uniprot id: E6WXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

749222:NITSA RS10720
gene id: 749222:NITSA_RS10720
uniprot id: E6X3M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

749222:NITSA RS00940
gene id: 749222:NITSA_RS00940
uniprot id: E6WZ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

749222:NITSA RS00450
gene id: 749222:NITSA_RS00450
uniprot id: E6WYB2
names: Similarity
messages: Belongs to the HypD family.

749222:NITSA RS05035
gene id: 749222:NITSA_RS05035
uniprot id: E6X3H1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

749222:NITSA RS09290
gene id: 749222:NITSA_RS09290
uniprot id: E6X218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS07230
gene id: 749222:NITSA_RS07230
uniprot id: E6WZN4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

749222:NITSA RS03240
gene id: 749222:NITSA_RS03240
uniprot id: E6X1H2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

749222:NITSA RS05060
gene id: 749222:NITSA_RS05060
uniprot id: E6X3H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

749222:NITSA RS05055
gene id: 749222:NITSA_RS05055
uniprot id: E6X3H5
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

749222:NITSA RS01195
gene id: 749222:NITSA_RS01195
uniprot id: E6WZ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

749222:NITSA RS00985
gene id: 749222:NITSA_RS00985
uniprot id: E6WZ10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS01275
gene id: 749222:NITSA_RS01275
uniprot id: E6WZ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

749222:NITSA RS03855
gene id: 749222:NITSA_RS03855
uniprot id: E6X290
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

749222:NITSA RS02680
gene id: 749222:NITSA_RS02680
uniprot id: E6X0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

749222:NITSA RS05805
gene id: 749222:NITSA_RS05805
uniprot id: E6WY22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

749222:NITSA RS01690
gene id: 749222:NITSA_RS01690
uniprot id: E6WZU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

749222:NITSA RS01980
gene id: 749222:NITSA_RS01980
uniprot id: E6WZZ9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

749222:NITSA RS07965
gene id: 749222:NITSA_RS07965
uniprot id: E6X0H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

749222:NITSA RS01605
gene id: 749222:NITSA_RS01605
uniprot id: E6WZK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

749222:NITSA RS10060
gene id: 749222:NITSA_RS10060
uniprot id: E6X2V7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS05535
gene id: 749222:NITSA_RS05535
uniprot id: E6WXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

749222:NITSA RS06705
gene id: 749222:NITSA_RS06705
uniprot id: E6WYY7
names: Similarity
messages: Belongs to the SufE family.

749222:NITSA RS00955
gene id: 749222:NITSA_RS00955
uniprot id: E6WZ04
names: Subcellular Location Annotation
messages: Cytoplasm

749222:NITSA RS01385
gene id: 749222:NITSA_RS01385
uniprot id: E6WZG0
names: Function
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

749222:NITSA RS00835
gene id: 749222:NITSA_RS00835
uniprot id: E6WYR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS06660
gene id: 749222:NITSA_RS06660
uniprot id: E6WYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS06855
gene id: 749222:NITSA_RS06855
uniprot id: E6WZ91
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS00610
gene id: 749222:NITSA_RS00610
uniprot id: E6WYL6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

749222:NITSA RS07030
gene id: 749222:NITSA_RS07030
uniprot id: E6WZC6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

749222:NITSA RS04115
gene id: 749222:NITSA_RS04115
uniprot id: E6X2D5
names: Similarity
messages: Belongs to the RNase T2 family.

749222:NITSA RS03555
gene id: 749222:NITSA_RS03555
uniprot id: E6X1V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

749222:NITSA RS03890
gene id: 749222:NITSA_RS03890
uniprot id: E6X297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS00360
gene id: 749222:NITSA_RS00360
uniprot id: E6WY94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS08350
gene id: 749222:NITSA_RS08350
uniprot id: E6X0W8
names: Similarity
messages: Belongs to the GSP E family.

749222:NITSA RS09325
gene id: 749222:NITSA_RS09325
uniprot id: E6X225
names: Similarity
messages: Belongs to the UPF0234 family.

749222:NITSA RS00935
gene id: 749222:NITSA_RS00935
uniprot id: E6WZ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

749222:NITSA RS01030
gene id: 749222:NITSA_RS01030
uniprot id: E6WZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

749222:NITSA RS10010
gene id: 749222:NITSA_RS10010
uniprot id: E6X2U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS01260
gene id: 749222:NITSA_RS01260
uniprot id: E6WZ66
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

749222:NITSA RS02820
gene id: 749222:NITSA_RS02820
uniprot id: E6X120
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

749222:NITSA RS10320
gene id: 749222:NITSA_RS10320
uniprot id: E6X377
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

749222:NITSA RS05710
gene id: 749222:NITSA_RS05710
uniprot id: E6WY02
names: Similarity
messages: Belongs to the LacAB/RpiB family.

749222:NITSA RS08815
gene id: 749222:NITSA_RS08815
uniprot id: E6X1C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

749222:NITSA RS05380
gene id: 749222:NITSA_RS05380
uniprot id: E6WXQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

749222:NITSA RS05835
gene id: 749222:NITSA_RS05835
uniprot id: E6WY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

749222:NITSA RS00650
gene id: 749222:NITSA_RS00650
uniprot id: E6WYM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

749222:NITSA RS00070
gene id: 749222:NITSA_RS00070
uniprot id: E6WXW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

749222:NITSA RS01820
gene id: 749222:NITSA_RS01820
uniprot id: E6WZW7
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

749222:NITSA RS03380
gene id: 749222:NITSA_RS03380
uniprot id: E6X1K0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

749222:NITSA RS08415
gene id: 749222:NITSA_RS08415
uniprot id: E6X0Y0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

749222:NITSA RS10350
gene id: 749222:NITSA_RS10350
uniprot id: E6X383
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

749222:NITSA RS09375
gene id: 749222:NITSA_RS09375
uniprot id: E6X235
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS01835
gene id: 749222:NITSA_RS01835
uniprot id: E6WZX0
names: Similarity
messages: Belongs to the class-I fumarase family.

749222:NITSA RS03710
gene id: 749222:NITSA_RS03710
uniprot id: E6X1Z0
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

749222:NITSA RS10020
gene id: 749222:NITSA_RS10020
uniprot id: E6X2U9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

749222:NITSA RS04955
gene id: 749222:NITSA_RS04955
uniprot id: E6X3F5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

749222:NITSA RS00560
gene id: 749222:NITSA_RS00560
uniprot id: E6WYK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

749222:NITSA RS04680
gene id: 749222:NITSA_RS04680
uniprot id: E6X335
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

749222:NITSA RS07175
gene id: 749222:NITSA_RS07175
uniprot id: E6WZM3
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

749222:NITSA RS03265
gene id: 749222:NITSA_RS03265
uniprot id: E6X1H7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

749222:NITSA RS06375
gene id: 749222:NITSA_RS06375
uniprot id: E6WYS6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS03290
gene id: 749222:NITSA_RS03290
uniprot id: E6X1I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS05520
gene id: 749222:NITSA_RS05520
uniprot id: E6WXT4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

749222:NITSA RS07540
gene id: 749222:NITSA_RS07540
uniprot id: E6X013
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS03900
gene id: 749222:NITSA_RS03900
uniprot id: E6X299
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

749222:NITSA RS03715
gene id: 749222:NITSA_RS03715
uniprot id: E6X1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

749222:NITSA RS07995
gene id: 749222:NITSA_RS07995
uniprot id: E6X0H9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

749222:NITSA RS05815
gene id: 749222:NITSA_RS05815
uniprot id: E6WY24
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

749222:NITSA RS05200
gene id: 749222:NITSA_RS05200
uniprot id: E6X3K3
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00635
gene id: 749222:NITSA_RS00635
uniprot id: E6WYM1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

749222:NITSA RS03200
gene id: 749222:NITSA_RS03200
uniprot id: E6X1G2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

749222:NITSA RS10650
gene id: 749222:NITSA_RS10650
uniprot id: E6X3D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

749222:NITSA RS04345
gene id: 749222:NITSA_RS04345
uniprot id: E6X2P8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

749222:NITSA RS06665
gene id: 749222:NITSA_RS06665
uniprot id: E6WYX9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

749222:NITSA RS01330
gene id: 749222:NITSA_RS01330
uniprot id: E6WZE9
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

749222:NITSA RS00750
gene id: 749222:NITSA_RS00750
uniprot id: E6WYP3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

749222:NITSA RS06845
gene id: 749222:NITSA_RS06845
uniprot id: E6WZ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

749222:NITSA RS09805
gene id: 749222:NITSA_RS09805
uniprot id: E6X2I8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

749222:NITSA RS00975
gene id: 749222:NITSA_RS00975
uniprot id: E6WZ08
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

749222:NITSA RS00600
gene id: 749222:NITSA_RS00600
uniprot id: E6WYL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

749222:NITSA RS09460
gene id: 749222:NITSA_RS09460
uniprot id: E6X252
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

749222:NITSA RS02370
gene id: 749222:NITSA_RS02370
uniprot id: E6X0L4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

749222:NITSA RS04730
gene id: 749222:NITSA_RS04730
uniprot id: E6X343
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01035
gene id: 749222:NITSA_RS01035
uniprot id: E6WZ20
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

749222:NITSA RS01270
gene id: 749222:NITSA_RS01270
uniprot id: E6WZ68
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

749222:NITSA RS01375
gene id: 749222:NITSA_RS01375
uniprot id: E6WZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

749222:NITSA RS05020
gene id: 749222:NITSA_RS05020
uniprot id: E6X3G8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

749222:NITSA RS10085
gene id: 749222:NITSA_RS10085
uniprot id: E6X2W1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03110
gene id: 749222:NITSA_RS03110
uniprot id: E6X1E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

749222:NITSA RS07245
gene id: 749222:NITSA_RS07245
uniprot id: E6WZN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

749222:NITSA RS00815
gene id: 749222:NITSA_RS00815
uniprot id: E6WYQ6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

749222:NITSA RS00770
gene id: 749222:NITSA_RS00770
uniprot id: E6WYP7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

749222:NITSA RS06260
gene id: 749222:NITSA_RS06260
uniprot id: E6WYH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

749222:NITSA RS07410
gene id: 749222:NITSA_RS07410
uniprot id: E6WZS0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

749222:NITSA RS08585
gene id: 749222:NITSA_RS08585
uniprot id: E6X177
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

749222:NITSA RS02905
gene id: 749222:NITSA_RS02905
uniprot id: E6X136
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

749222:NITSA RS05570
gene id: 749222:NITSA_RS05570
uniprot id: E6WXU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01915
gene id: 749222:NITSA_RS01915
uniprot id: E6WZY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

749222:NITSA RS05800
gene id: 749222:NITSA_RS05800
uniprot id: E6WY21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

749222:NITSA RS06195
gene id: 749222:NITSA_RS06195
uniprot id: E6WYG3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00325
gene id: 749222:NITSA_RS00325
uniprot id: E6WY86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

749222:NITSA RS08060
gene id: 749222:NITSA_RS08060
uniprot id: E6X0J2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

749222:NITSA RS06180
gene id: 749222:NITSA_RS06180
uniprot id: E6WYG0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

749222:NITSA RS08395
gene id: 749222:NITSA_RS08395
uniprot id: E6X0X7
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

749222:NITSA RS05415
gene id: 749222:NITSA_RS05415
uniprot id: E6WXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

749222:NITSA RS01470
gene id: 749222:NITSA_RS01470
uniprot id: E6WZH7
names: Similarity
messages: Belongs to the ClpA/ClpB family.

749222:NITSA RS05730
gene id: 749222:NITSA_RS05730
uniprot id: E6WY06
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

749222:NITSA RS00505
gene id: 749222:NITSA_RS00505
uniprot id: E6WYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm

749222:NITSA RS10545
gene id: 749222:NITSA_RS10545
uniprot id: E6X3B9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

749222:NITSA RS10930
gene id: 749222:NITSA_RS10930
uniprot id: E6X0E5
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS10515
gene id: 749222:NITSA_RS10515
uniprot id: E6X3B3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

749222:NITSA RS02070
gene id: 749222:NITSA_RS02070
uniprot id: E6X086
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

749222:NITSA RS08345
gene id: 749222:NITSA_RS08345
uniprot id: E6X0W7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

749222:NITSA RS00455
gene id: 749222:NITSA_RS00455
uniprot id: E6WYB3
names: Similarity
messages: Belongs to the HypE family.

749222:NITSA RS04960
gene id: 749222:NITSA_RS04960
uniprot id: E6X3F6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07285
gene id: 749222:NITSA_RS07285
uniprot id: E6WZP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

749222:NITSA RS06960
gene id: 749222:NITSA_RS06960
uniprot id: E6WZB3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

749222:NITSA RS03560
gene id: 749222:NITSA_RS03560
uniprot id: E6X1W0
names: Similarity
messages: Belongs to the UPF0235 family.

749222:NITSA RS04010
gene id: 749222:NITSA_RS04010
uniprot id: E6X2B5
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS04415
gene id: 749222:NITSA_RS04415
uniprot id: E6X2R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

749222:NITSA RS02380
gene id: 749222:NITSA_RS02380
uniprot id: E6X0L6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

749222:NITSA RS08355
gene id: 749222:NITSA_RS08355
uniprot id: E6X0W9
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS09540
gene id: 749222:NITSA_RS09540
uniprot id: E6X267
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

749222:NITSA RS00800
gene id: 749222:NITSA_RS00800
uniprot id: E6WYQ3
names: Similarity
messages: Belongs to the TrpF family.

749222:NITSA RS00720
gene id: 749222:NITSA_RS00720
uniprot id: E6WYN7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

749222:NITSA RS03495
gene id: 749222:NITSA_RS03495
uniprot id: E6X1U7
names: Similarity
messages: Belongs to the glutamine synthetase family.

749222:NITSA RS07500
gene id: 749222:NITSA_RS07500
uniprot id: E6X005
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

749222:NITSA RS00440
gene id: 749222:NITSA_RS00440
uniprot id: E6WYB0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

749222:NITSA RS09865
gene id: 749222:NITSA_RS09865
uniprot id: E6X2K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

749222:NITSA RS07240
gene id: 749222:NITSA_RS07240
uniprot id: E6WZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

749222:NITSA RS10780
gene id: 749222:NITSA_RS10780
uniprot id: E6X1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

749222:NITSA RS07325
gene id: 749222:NITSA_RS07325
uniprot id: E6WZQ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

749222:NITSA RS06160
gene id: 749222:NITSA_RS06160
uniprot id: E6WYF6
names: Similarity
messages: Belongs to the FUN14 family.

749222:NITSA RS08760
gene id: 749222:NITSA_RS08760
uniprot id: E6X1B3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

749222:NITSA RS08370
gene id: 749222:NITSA_RS08370
uniprot id: E6X0X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01230
gene id: 749222:NITSA_RS01230
uniprot id: E6WZ60
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

749222:NITSA RS07545
gene id: 749222:NITSA_RS07545
uniprot id: E6X014
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07600
gene id: 749222:NITSA_RS07600
uniprot id: E6X025
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

749222:NITSA RS09395
gene id: 749222:NITSA_RS09395
uniprot id: E6X239
names: Cofactor
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

749222:NITSA RS00840
gene id: 749222:NITSA_RS00840
uniprot id: E6WYR1
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

749222:NITSA RS02460
gene id: 749222:NITSA_RS02460
uniprot id: E6X0N2
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

749222:NITSA RS09405
gene id: 749222:NITSA_RS09405
uniprot id: E6X241
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

749222:NITSA RS05560
gene id: 749222:NITSA_RS05560
uniprot id: E6WXU2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS05460
gene id: 749222:NITSA_RS05460
uniprot id: E6WXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS04605
gene id: 749222:NITSA_RS04605
uniprot id: E6X322
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS02220
gene id: 749222:NITSA_RS02220
uniprot id: E6X0B6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

749222:NITSA RS06920
gene id: 749222:NITSA_RS06920
uniprot id: E6WZA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

749222:NITSA RS01190
gene id: 749222:NITSA_RS01190
uniprot id: E6WZ52
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS08550
gene id: 749222:NITSA_RS08550
uniprot id: E6X170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

749222:NITSA RS01495
gene id: 749222:NITSA_RS01495
uniprot id: E6WZI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

749222:NITSA RS04495
gene id: 749222:NITSA_RS04495
uniprot id: E6X2S8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

749222:NITSA RS03050
gene id: 749222:NITSA_RS03050
uniprot id: E6X165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

749222:NITSA RS00625
gene id: 749222:NITSA_RS00625
uniprot id: E6WYL9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

749222:NITSA RS05195
gene id: 749222:NITSA_RS05195
uniprot id: E6X3K2
names: Similarity
messages: Belongs to the P(II) protein family.

749222:NITSA RS10590
gene id: 749222:NITSA_RS10590
uniprot id: E6X3C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS06175
gene id: 749222:NITSA_RS06175
uniprot id: E6WYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

749222:NITSA RS08620
gene id: 749222:NITSA_RS08620
uniprot id: E6X184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

749222:NITSA RS08455
gene id: 749222:NITSA_RS08455
uniprot id: E6X0Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

749222:NITSA RS01825
gene id: 749222:NITSA_RS01825
uniprot id: E6WZW8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

749222:NITSA RS06995
gene id: 749222:NITSA_RS06995
uniprot id: E6WZC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates guanosine-37 in various tRNAs.

749222:NITSA RS05120
gene id: 749222:NITSA_RS05120
uniprot id: E6X3I7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

749222:NITSA RS09900
gene id: 749222:NITSA_RS09900
uniprot id: E6X2K7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

749222:NITSA RS05235
gene id: 749222:NITSA_RS05235
uniprot id: E6X3L0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

749222:NITSA RS09165
gene id: 749222:NITSA_RS09165
uniprot id: E6X1S0
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

749222:NITSA RS08900
gene id: 749222:NITSA_RS08900
uniprot id: E6X1L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

749222:NITSA RS09870
gene id: 749222:NITSA_RS09870
uniprot id: E6X2K1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

749222:NITSA RS08360
gene id: 749222:NITSA_RS08360
uniprot id: E6X0X0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS09235
gene id: 749222:NITSA_RS09235
uniprot id: E6X206
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

749222:NITSA RS05090
gene id: 749222:NITSA_RS05090
uniprot id: E6X3I2
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

749222:NITSA RS04235
gene id: 749222:NITSA_RS04235
uniprot id: E6X2M8
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS03705
gene id: 749222:NITSA_RS03705
uniprot id: E6X1Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

749222:NITSA RS09350
gene id: 749222:NITSA_RS09350
uniprot id: E6X230
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

749222:NITSA RS10145
gene id: 749222:NITSA_RS10145
uniprot id: E6X2X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

749222:NITSA RS02165
gene id: 749222:NITSA_RS02165
uniprot id: E6X0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

749222:NITSA RS00015
gene id: 749222:NITSA_RS00015
uniprot id: E6WXV6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS04375
gene id: 749222:NITSA_RS04375
uniprot id: E6X2Q4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS02950
gene id: 749222:NITSA_RS02950
uniprot id: E6X145
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

749222:NITSA RS09670
gene id: 749222:NITSA_RS09670
uniprot id: E6X2F9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

749222:NITSA RS04570
gene id: 749222:NITSA_RS04570
uniprot id: E6X315
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

749222:NITSA RS08235
gene id: 749222:NITSA_RS08235
uniprot id: E6X0U5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

749222:NITSA RS00830
gene id: 749222:NITSA_RS00830
uniprot id: E6WYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS04500
gene id: 749222:NITSA_RS04500
uniprot id: E6X2S9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS06835
gene id: 749222:NITSA_RS06835
uniprot id: E6WZ87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

749222:NITSA RS01995
gene id: 749222:NITSA_RS01995
uniprot id: E6X071
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS01295
gene id: 749222:NITSA_RS01295
uniprot id: E6WZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

749222:NITSA RS09390
gene id: 749222:NITSA_RS09390
uniprot id: E6X238
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

749222:NITSA RS03220
gene id: 749222:NITSA_RS03220
uniprot id: E6X1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

749222:NITSA RS07885
gene id: 749222:NITSA_RS07885
uniprot id: E6X0F5
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS01665
gene id: 749222:NITSA_RS01665
uniprot id: E6WZT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

749222:NITSA RS06435
gene id: 749222:NITSA_RS06435
uniprot id: E6WYT8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

749222:NITSA RS01285
gene id: 749222:NITSA_RS01285
uniprot id: E6WZE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

749222:NITSA RS00630
gene id: 749222:NITSA_RS00630
uniprot id: E6WYM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

749222:NITSA RS00585
gene id: 749222:NITSA_RS00585
uniprot id: E6WYL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

749222:NITSA RS04830
gene id: 749222:NITSA_RS04830
uniprot id: E6X363
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS05455
gene id: 749222:NITSA_RS05455
uniprot id: E6WXS0
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

749222:NITSA RS03870
gene id: 749222:NITSA_RS03870
uniprot id: E6X293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

749222:NITSA RS02900
gene id: 749222:NITSA_RS02900
uniprot id: E6X135
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

749222:NITSA RS09310
gene id: 749222:NITSA_RS09310
uniprot id: E6X222
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS08840
gene id: 749222:NITSA_RS08840
uniprot id: E6X1C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

749222:NITSA RS04380
gene id: 749222:NITSA_RS04380
uniprot id: E6X2Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

749222:NITSA RS03145
gene id: 749222:NITSA_RS03145
uniprot id: E6X1F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

749222:NITSA RS02640
gene id: 749222:NITSA_RS02640
uniprot id: E6X0R7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS09270
gene id: 749222:NITSA_RS09270
uniprot id: E6X214
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

749222:NITSA RS00280
gene id: 749222:NITSA_RS00280
uniprot id: E6WY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS07660
gene id: 749222:NITSA_RS07660
uniprot id: E6X037
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

749222:NITSA RS10165
gene id: 749222:NITSA_RS10165
uniprot id: E6X2X7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

749222:NITSA RS05230
gene id: 749222:NITSA_RS05230
uniprot id: E6X3K9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS04840
gene id: 749222:NITSA_RS04840
uniprot id: E6X365
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

749222:NITSA RS06350
gene id: 749222:NITSA_RS06350
uniprot id: E6WYJ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS06720
gene id: 749222:NITSA_RS06720
uniprot id: E6WYZ0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

749222:NITSA RS08765
gene id: 749222:NITSA_RS08765
uniprot id: E6X1B4
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

749222:NITSA RS07980
gene id: 749222:NITSA_RS07980
uniprot id: E6X0H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS04195
gene id: 749222:NITSA_RS04195
uniprot id: E6X2M0
names: Similarity
messages: Belongs to the ArsC family.

749222:NITSA RS04775
gene id: 749222:NITSA_RS04775
uniprot id: E6X352
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

749222:NITSA RS04510
gene id: 749222:NITSA_RS04510
uniprot id: E6X2T1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

749222:NITSA RS02270
gene id: 749222:NITSA_RS02270
uniprot id: E6X0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

749222:NITSA RS01540
gene id: 749222:NITSA_RS01540
uniprot id: E6WZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

749222:NITSA RS10440
gene id: 749222:NITSA_RS10440
uniprot id: E6X399
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

749222:NITSA RS07635
gene id: 749222:NITSA_RS07635
uniprot id: E6X032
names: Similarity
messages: Belongs to the DEAD box helicase family.

749222:NITSA RS00820
gene id: 749222:NITSA_RS00820
uniprot id: E6WYQ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS04980
gene id: 749222:NITSA_RS04980
uniprot id: E6X3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS04625
gene id: 749222:NITSA_RS04625
uniprot id: E6X326
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00555
gene id: 749222:NITSA_RS00555
uniprot id: E6WYK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

749222:NITSA RS07380
gene id: 749222:NITSA_RS07380
uniprot id: E6WZR4
names: Similarity
messages: Belongs to the YkuD family.

749222:NITSA RS04470
gene id: 749222:NITSA_RS04470
uniprot id: E6X2S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS00040
gene id: 749222:NITSA_RS00040
uniprot id: E6WXW1
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

749222:NITSA RS06165
gene id: 749222:NITSA_RS06165
uniprot id: E6WYF7
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

749222:NITSA RS09495
gene id: 749222:NITSA_RS09495
uniprot id: E6X259
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

749222:NITSA RS03490
gene id: 749222:NITSA_RS03490
uniprot id: E6X1U6
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

749222:NITSA RS05165
gene id: 749222:NITSA_RS05165
uniprot id: E6X3J6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

749222:NITSA RS10185
gene id: 749222:NITSA_RS10185
uniprot id: E6X2Y0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

749222:NITSA RS10450
gene id: 749222:NITSA_RS10450
uniprot id: E6X3A1
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS08775
gene id: 749222:NITSA_RS08775
uniprot id: E6X1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS04865
gene id: 749222:NITSA_RS04865
uniprot id: E6X370
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

749222:NITSA RS07145
gene id: 749222:NITSA_RS07145
uniprot id: E6WZL7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

749222:NITSA RS00525
gene id: 749222:NITSA_RS00525
uniprot id: E6WYJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

749222:NITSA RS03660
gene id: 749222:NITSA_RS03660
uniprot id: E6X1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

749222:NITSA RS08890
gene id: 749222:NITSA_RS08890
uniprot id: E6X1L1
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

749222:NITSA RS01365
gene id: 749222:NITSA_RS01365
uniprot id: E6WZF6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00305
gene id: 749222:NITSA_RS00305
uniprot id: E6WY82
names: Similarity
messages: Belongs to the UPF0047 family.

749222:NITSA RS09255
gene id: 749222:NITSA_RS09255
uniprot id: E6X210
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

749222:NITSA RS10245
gene id: 749222:NITSA_RS10245
uniprot id: E6X2Z2
names: Similarity
messages: Belongs to the TPP enzyme family.

749222:NITSA RS02815
gene id: 749222:NITSA_RS02815
uniprot id: E6X119
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00990
gene id: 749222:NITSA_RS00990
uniprot id: E6WZ11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS03760
gene id: 749222:NITSA_RS03760
uniprot id: E6X1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS10140
gene id: 749222:NITSA_RS10140
uniprot id: E6X2X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

749222:NITSA RS01600
gene id: 749222:NITSA_RS01600
uniprot id: E6WZK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS01215
gene id: 749222:NITSA_RS01215
uniprot id: E6WZ57
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

749222:NITSA RS00250
gene id: 749222:NITSA_RS00250
uniprot id: E6WY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

749222:NITSA RS02030
gene id: 749222:NITSA_RS02030
uniprot id: E6X078
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

749222:NITSA RS02355
gene id: 749222:NITSA_RS02355
uniprot id: E6X0L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

749222:NITSA RS00905
gene id: 749222:NITSA_RS00905
uniprot id: E6WYS4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

749222:NITSA RS00465
gene id: 749222:NITSA_RS00465
uniprot id: E6WYB5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

749222:NITSA RS01510
gene id: 749222:NITSA_RS01510
uniprot id: E6WZI5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

749222:NITSA RS09455
gene id: 749222:NITSA_RS09455
uniprot id: E6X251
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

749222:NITSA RS00885
gene id: 749222:NITSA_RS00885
uniprot id: E6WYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS03175
gene id: 749222:NITSA_RS03175
uniprot id: E6X1G0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

749222:NITSA RS04285
gene id: 749222:NITSA_RS04285
uniprot id: E6X2N7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

749222:NITSA RS07850
gene id: 749222:NITSA_RS07850
uniprot id: E6X0E8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

749222:NITSA RS06905
gene id: 749222:NITSA_RS06905
uniprot id: E6WZA1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00385
gene id: 749222:NITSA_RS00385
uniprot id: E6WY99
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

749222:NITSA RS09985
gene id: 749222:NITSA_RS09985
uniprot id: E6X2U2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

749222:NITSA RS10455
gene id: 749222:NITSA_RS10455
uniprot id: E6X3A2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

749222:NITSA RS08325
gene id: 749222:NITSA_RS08325
uniprot id: E6X0W3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS06370
gene id: 749222:NITSA_RS06370
uniprot id: E6WYS5
names: Similarity
messages: Belongs to the DEAD box helicase family.

749222:NITSA RS01490
gene id: 749222:NITSA_RS01490
uniprot id: E6WZI1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.

749222:NITSA RS05290
gene id: 749222:NITSA_RS05290
uniprot id: E6WXP1
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

749222:NITSA RS07330
gene id: 749222:NITSA_RS07330
uniprot id: E6WZQ4
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

749222:NITSA RS02595
gene id: 749222:NITSA_RS02595
uniprot id: E6X0Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

749222:NITSA RS09665
gene id: 749222:NITSA_RS09665
uniprot id: E6X2F8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

749222:NITSA RS04445
gene id: 749222:NITSA_RS04445
uniprot id: E6X2R8
names: Similarity
messages: Belongs to the CcdB toxin family.

749222:NITSA RS02170
gene id: 749222:NITSA_RS02170
uniprot id: E6X0A6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

749222:NITSA RS04405
gene id: 749222:NITSA_RS04405
uniprot id: E6X2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

749222:NITSA RS03105
gene id: 749222:NITSA_RS03105
uniprot id: E6X1E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

749222:NITSA RS00845
gene id: 749222:NITSA_RS00845
uniprot id: E6WYR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

749222:NITSA RS04310
gene id: 749222:NITSA_RS04310
uniprot id: E6X2P2
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

749222:NITSA RS09490
gene id: 749222:NITSA_RS09490
uniprot id: E6X258
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS07790
gene id: 749222:NITSA_RS07790
uniprot id: E6X063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

749222:NITSA RS09435
gene id: 749222:NITSA_RS09435
uniprot id: E6X247
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

749222:NITSA RS07785
gene id: 749222:NITSA_RS07785
uniprot id: E6X062
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

749222:NITSA RS04810
gene id: 749222:NITSA_RS04810
uniprot id: E6X359
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

749222:NITSA RS01455
gene id: 749222:NITSA_RS01455
uniprot id: E6WZH4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

749222:NITSA RS08885
gene id: 749222:NITSA_RS08885
uniprot id: E6X1L0
names: Similarity
messages: Belongs to the polypeptide deformylase family.

749222:NITSA RS09880
gene id: 749222:NITSA_RS09880
uniprot id: E6X2K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

749222:NITSA RS05130
gene id: 749222:NITSA_RS05130
uniprot id: E6X3I9
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

749222:NITSA RS05080
gene id: 749222:NITSA_RS05080
uniprot id: E6X3I0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

749222:NITSA RS00890
gene id: 749222:NITSA_RS00890
uniprot id: E6WYS1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

749222:NITSA RS07695
gene id: 749222:NITSA_RS07695
uniprot id: E6X044
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

749222:NITSA RS08420
gene id: 749222:NITSA_RS08420
uniprot id: E6X0Y1
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspF family.
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS00595
gene id: 749222:NITSA_RS00595
uniprot id: E6WYL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

749222:NITSA RS00085
gene id: 749222:NITSA_RS00085
uniprot id: E6WXX0
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS09700
gene id: 749222:NITSA_RS09700
uniprot id: E6X2G6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

749222:NITSA RS01475
gene id: 749222:NITSA_RS01475
uniprot id: E6WZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

749222:NITSA RS05140
gene id: 749222:NITSA_RS05140
uniprot id: E6X3J1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS03310
gene id: 749222:NITSA_RS03310
uniprot id: E6X1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

749222:NITSA RS06810
gene id: 749222:NITSA_RS06810
uniprot id: E6WZ82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS10740
gene id: 749222:NITSA_RS10740
uniprot id: E6WZG8
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

749222:NITSA RS08580
gene id: 749222:NITSA_RS08580
uniprot id: E6X176
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

749222:NITSA RS00340
gene id: 749222:NITSA_RS00340
uniprot id: E6WY89
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

749222:NITSA RS10190
gene id: 749222:NITSA_RS10190
uniprot id: E6X2Y1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

749222:NITSA RS00420
gene id: 749222:NITSA_RS00420
uniprot id: E6WYA6
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS07455
gene id: 749222:NITSA_RS07455
uniprot id: E6WZS8
names: Similarity
messages: Belongs to the CutA family.

749222:NITSA RS02225
gene id: 749222:NITSA_RS02225
uniprot id: E6X0B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

749222:NITSA RS01335
gene id: 749222:NITSA_RS01335
uniprot id: E6WZF0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

749222:NITSA RS05720
gene id: 749222:NITSA_RS05720
uniprot id: E6WY04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

749222:NITSA RS08295
gene id: 749222:NITSA_RS08295
uniprot id: E6X0V7
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS06820
gene id: 749222:NITSA_RS06820
uniprot id: E6WZ84
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

749222:NITSA RS00590
gene id: 749222:NITSA_RS00590
uniprot id: E6WYL2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

749222:NITSA RS10675
gene id: 749222:NITSA_RS10675
uniprot id: E6X3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

749222:NITSA RS05150
gene id: 749222:NITSA_RS05150
uniprot id: E6X3J3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS05780
gene id: 749222:NITSA_RS05780
uniprot id: E6WY17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS10635
gene id: 749222:NITSA_RS10635
uniprot id: E6X3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

749222:NITSA RS00160
gene id: 749222:NITSA_RS00160
uniprot id: E6WXY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS07595
gene id: 749222:NITSA_RS07595
uniprot id: E6X024
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

749222:NITSA RS01290
gene id: 749222:NITSA_RS01290
uniprot id: E6WZE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

749222:NITSA RS05300
gene id: 749222:NITSA_RS05300
uniprot id: E6WXP3
names: Similarity
messages: Belongs to the SfsA family.

749222:NITSA RS01020
gene id: 749222:NITSA_RS01020
uniprot id: E6WZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

749222:NITSA RS02310
gene id: 749222:NITSA_RS02310
uniprot id: E6X0D4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

749222:NITSA RS10360
gene id: 749222:NITSA_RS10360
uniprot id: E6X385
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

749222:NITSA RS06135
gene id: 749222:NITSA_RS06135
uniprot id: E6WYF1
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS00780
gene id: 749222:NITSA_RS00780
uniprot id: E6WYP9
names: Similarity
messages: Belongs to the MEMO1 family.

749222:NITSA RS04535
gene id: 749222:NITSA_RS04535
uniprot id: E6X308
names: Similarity
messages: Belongs to the UPF0758 family.

749222:NITSA RS04505
gene id: 749222:NITSA_RS04505
uniprot id: E6X2T0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

749222:NITSA RS07465
gene id: 749222:NITSA_RS07465
uniprot id: E6WZT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

749222:NITSA RS00320
gene id: 749222:NITSA_RS00320
uniprot id: E6WY85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

749222:NITSA RS03330
gene id: 749222:NITSA_RS03330
uniprot id: E6X1J0
names: Similarity
messages: Belongs to the peptidase M16 family.

749222:NITSA RS01960
gene id: 749222:NITSA_RS01960
uniprot id: E6WZZ5
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

749222:NITSA RS02150
gene id: 749222:NITSA_RS02150
uniprot id: E6X0A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

749222:NITSA RS06275
gene id: 749222:NITSA_RS06275
uniprot id: E6WYH9
names: Subcellular Location Annotation
messages: Membrane

749222:NITSA RS09820
gene id: 749222:NITSA_RS09820
uniprot id: E6X2J1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

749222:NITSA RS08365
gene id: 749222:NITSA_RS08365
uniprot id: E6X0X1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

749222:NITSA RS00075
gene id: 749222:NITSA_RS00075
uniprot id: E6WXW8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

749222:NITSA RS10365
gene id: 749222:NITSA_RS10365
uniprot id: E6X386
names: Similarity
messages: Belongs to the asparagine synthetase family.

749222:NITSA RS09885
gene id: 749222:NITSA_RS09885
uniprot id: E6X2K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.