744872:SPICA RS08370
gene id: 744872:SPICA_RS08370
uniprot id: F8F0T2
names: Similarity
messages: Belongs to the glutamine synthetase family.

744872:SPICA RS08715
gene id: 744872:SPICA_RS08715
uniprot id: F8F209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

744872:SPICA RS05700
gene id: 744872:SPICA_RS05700
uniprot id: F8EZ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

744872:SPICA RS06925
gene id: 744872:SPICA_RS06925
uniprot id: F8F3D2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

744872:SPICA RS07925
gene id: 744872:SPICA_RS07925
uniprot id: F8EZB2
names: Similarity
messages: Belongs to the CobT family.

744872:SPICA RS02370
gene id: 744872:SPICA_RS02370
uniprot id: F8EYP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

744872:SPICA RS06550
gene id: 744872:SPICA_RS06550
uniprot id: F8F2N9
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS10230
gene id: 744872:SPICA_RS10230
uniprot id: F8EXX9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

744872:SPICA RS06105
gene id: 744872:SPICA_RS06105
uniprot id: F8F0K0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

744872:SPICA RS05560
gene id: 744872:SPICA_RS05560
uniprot id: F8EZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

744872:SPICA RS11845
gene id: 744872:SPICA_RS11845
uniprot id: F8F3S5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

744872:SPICA RS03880
gene id: 744872:SPICA_RS03880
uniprot id: F8EYX7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

744872:SPICA RS07505
gene id: 744872:SPICA_RS07505
uniprot id: F8EXN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

744872:SPICA RS09395
gene id: 744872:SPICA_RS09395
uniprot id: F8F3N8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

744872:SPICA RS07750
gene id: 744872:SPICA_RS07750
uniprot id: F8EZ76
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

744872:SPICA RS11350
gene id: 744872:SPICA_RS11350
uniprot id: F8F280
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13885
gene id: 744872:SPICA_RS13885
uniprot id: F8F149
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

744872:SPICA RS09840
gene id: 744872:SPICA_RS09840
uniprot id: F8F446
names: Caution
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS08030
gene id: 744872:SPICA_RS08030
uniprot id: F8F0L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

744872:SPICA RS09460
gene id: 744872:SPICA_RS09460
uniprot id: F8F3Q2
names: Similarity
messages: Belongs to the glutamate synthase family.

744872:SPICA RS01845
gene id: 744872:SPICA_RS01845
uniprot id: F8EX03
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01670
gene id: 744872:SPICA_RS01670
uniprot id: F8EZY3
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

744872:SPICA RS13190
gene id: 744872:SPICA_RS13190
uniprot id: F8EY39
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

744872:SPICA RS05215
gene id: 744872:SPICA_RS05215
uniprot id: F8EXF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

744872:SPICA RS02920
gene id: 744872:SPICA_RS02920
uniprot id: F8F192
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

744872:SPICA RS05130
gene id: 744872:SPICA_RS05130
uniprot id: F8EXD5
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

744872:SPICA RS07210
gene id: 744872:SPICA_RS07210
uniprot id: F8F3I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

744872:SPICA RS01220
gene id: 744872:SPICA_RS01220
uniprot id: F8EYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

744872:SPICA RS04915
gene id: 744872:SPICA_RS04915
uniprot id: F8F2K4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

744872:SPICA RS05935
gene id: 744872:SPICA_RS05935
uniprot id: F8F0G5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

744872:SPICA RS10920
gene id: 744872:SPICA_RS10920
uniprot id: F8F0Z2
names: Similarity
messages: Belongs to the Fur family.

744872:SPICA RS11265
gene id: 744872:SPICA_RS11265
uniprot id: F8F266
names: Similarity
messages: Belongs to the glycosyl hydrolase.

744872:SPICA RS10030
gene id: 744872:SPICA_RS10030
uniprot id: F8EXT9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

744872:SPICA RS12460
gene id: 744872:SPICA_RS12460
uniprot id: F8F4B7
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

744872:SPICA RS01960
gene id: 744872:SPICA_RS01960
uniprot id: F8EX23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS09810
gene id: 744872:SPICA_RS09810
uniprot id: F8F440
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

744872:SPICA RS08505
gene id: 744872:SPICA_RS08505
uniprot id: F8F1W7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

744872:SPICA RS03475
gene id: 744872:SPICA_RS03475
uniprot id: F8EXA0
names: Similarity
messages: Belongs to the UPF0045 family.

744872:SPICA RS03590
gene id: 744872:SPICA_RS03590
uniprot id: F8EYS0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

744872:SPICA RS09165
gene id: 744872:SPICA_RS09165
uniprot id: F8F3J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS00720
gene id: 744872:SPICA_RS00720
uniprot id: F8EWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS08870
gene id: 744872:SPICA_RS08870
uniprot id: F8F321
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS00135
gene id: 744872:SPICA_RS00135
uniprot id: F8EWN6
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

744872:SPICA RS04900
gene id: 744872:SPICA_RS04900
uniprot id: F8F2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

744872:SPICA RS01970
gene id: 744872:SPICA_RS01970
uniprot id: F8EX25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

744872:SPICA RS05720
gene id: 744872:SPICA_RS05720
uniprot id: F8EZ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

744872:SPICA RS04935
gene id: 744872:SPICA_RS04935
uniprot id: F8F2K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

744872:SPICA RS00575
gene id: 744872:SPICA_RS00575
uniprot id: F8EYC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS11870
gene id: 744872:SPICA_RS11870
uniprot id: F8F3T0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

744872:SPICA RS07530
gene id: 744872:SPICA_RS07530
uniprot id: F8EXP4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS06615
gene id: 744872:SPICA_RS06615
uniprot id: F8F2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

744872:SPICA RS03345
gene id: 744872:SPICA_RS03345
uniprot id: F8EX74
names: Similarity
messages: Belongs to the UMP kinase family.

744872:SPICA RS03650
gene id: 744872:SPICA_RS03650
uniprot id: F8EYT1
names: Similarity
messages: Belongs to the alkaline phosphatase family.

744872:SPICA RS13495
gene id: 744872:SPICA_RS13495
uniprot id: F8EZN6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS13595
gene id: 744872:SPICA_RS13595
uniprot id: F8EZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS01965
gene id: 744872:SPICA_RS01965
uniprot id: F8EX24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

744872:SPICA RS13130
gene id: 744872:SPICA_RS13130
uniprot id: F8EY27
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

744872:SPICA RS03985
gene id: 744872:SPICA_RS03985
uniprot id: F8F076
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

744872:SPICA RS12615
gene id: 744872:SPICA_RS12615
uniprot id: F8F4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

744872:SPICA RS04790
gene id: 744872:SPICA_RS04790
uniprot id: F8F2I0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

744872:SPICA RS03045
gene id: 744872:SPICA_RS03045
uniprot id: F8F1B5
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

744872:SPICA RS08020
gene id: 744872:SPICA_RS08020
uniprot id: F8F0L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

744872:SPICA RS08765
gene id: 744872:SPICA_RS08765
uniprot id: F8F2V8
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09340
gene id: 744872:SPICA_RS09340
uniprot id: F8F3M9
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

744872:SPICA RS13385
gene id: 744872:SPICA_RS13385
uniprot id: F8EZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

744872:SPICA RS07495
gene id: 744872:SPICA_RS07495
uniprot id: F8EXN7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

744872:SPICA RS14030
gene id: 744872:SPICA_RS14030
uniprot id: F8F286
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

744872:SPICA RS04705
gene id: 744872:SPICA_RS04705
uniprot id: F8F2G3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

744872:SPICA RS10770
gene id: 744872:SPICA_RS10770
uniprot id: F8F0W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS04695
gene id: 744872:SPICA_RS04695
uniprot id: F8F2G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

744872:SPICA RS12185
gene id: 744872:SPICA_RS12185
uniprot id: F8F464
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS13065
gene id: 744872:SPICA_RS13065
uniprot id: F8EY14
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

744872:SPICA RS09630
gene id: 744872:SPICA_RS09630
uniprot id: F8F409
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

744872:SPICA RS12500
gene id: 744872:SPICA_RS12500
uniprot id: F8F4C2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

744872:SPICA RS04400
gene id: 744872:SPICA_RS04400
uniprot id: F8F1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS08500
gene id: 744872:SPICA_RS08500
uniprot id: F8F1W6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane

744872:SPICA RS04140
gene id: 744872:SPICA_RS04140
uniprot id: F8F0A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

744872:SPICA RS10070
gene id: 744872:SPICA_RS10070
uniprot id: F8EXU7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

744872:SPICA RS08625
gene id: 744872:SPICA_RS08625
uniprot id: F8F1Z1
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

744872:SPICA RS08190
gene id: 744872:SPICA_RS08190
uniprot id: F8F0P7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

744872:SPICA RS08700
gene id: 744872:SPICA_RS08700
uniprot id: F8F206
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

744872:SPICA RS09635
gene id: 744872:SPICA_RS09635
uniprot id: F8F410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS12540
gene id: 744872:SPICA_RS12540
uniprot id: F8F4D1
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS11850
gene id: 744872:SPICA_RS11850
uniprot id: F8F3S6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

744872:SPICA RS09895
gene id: 744872:SPICA_RS09895
uniprot id: F8F457
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

744872:SPICA RS11710
gene id: 744872:SPICA_RS11710
uniprot id: F8F392
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

744872:SPICA RS07150
gene id: 744872:SPICA_RS07150
uniprot id: F8F3H5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

744872:SPICA RS14510
gene id: 744872:SPICA_RS14510
uniprot id: F8F3C3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

744872:SPICA RS07175
gene id: 744872:SPICA_RS07175
uniprot id: F8F3I1
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

744872:SPICA RS13625
gene id: 744872:SPICA_RS13625
uniprot id: F8EZR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

744872:SPICA RS04945
gene id: 744872:SPICA_RS04945
uniprot id: F8F2L0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

744872:SPICA RS02785
gene id: 744872:SPICA_RS02785
uniprot id: F8F056
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

744872:SPICA RS04295
gene id: 744872:SPICA_RS04295
uniprot id: F8F0D6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

744872:SPICA RS03935
gene id: 744872:SPICA_RS03935
uniprot id: F8EYY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS02010
gene id: 744872:SPICA_RS02010
uniprot id: F8EX33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS13245
gene id: 744872:SPICA_RS13245
uniprot id: F8EY48
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

744872:SPICA RS04445
gene id: 744872:SPICA_RS04445
uniprot id: F8F1H6
names: Similarity
messages: Belongs to the CarB family.

744872:SPICA RS01935
gene id: 744872:SPICA_RS01935
uniprot id: F8EX18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

744872:SPICA RS00005
gene id: 744872:SPICA_RS00005
uniprot id: F8EWL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

744872:SPICA RS09410
gene id: 744872:SPICA_RS09410
uniprot id: F8F3P1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

744872:SPICA RS03300
gene id: 744872:SPICA_RS03300
uniprot id: F8EX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

744872:SPICA RS09115
gene id: 744872:SPICA_RS09115
uniprot id: F8F329
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

744872:SPICA RS02115
gene id: 744872:SPICA_RS02115
uniprot id: F8EYK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

744872:SPICA RS09495
gene id: 744872:SPICA_RS09495
uniprot id: F8F3Q9
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS05635
gene id: 744872:SPICA_RS05635
uniprot id: F8EZ25
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

744872:SPICA RS06920
gene id: 744872:SPICA_RS06920
uniprot id: F8F3D1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS05895
gene id: 744872:SPICA_RS05895
uniprot id: F8F0F7
names: Similarity
messages: Belongs to the UPF0235 family.

744872:SPICA RS09935
gene id: 744872:SPICA_RS09935
uniprot id: F8EXS0
names: Similarity
messages: Belongs to the DEAD box helicase family.

744872:SPICA RS02840
gene id: 744872:SPICA_RS02840
uniprot id: F8F067
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

744872:SPICA RS07805
gene id: 744872:SPICA_RS07805
uniprot id: F8EZ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

744872:SPICA RS10245
gene id: 744872:SPICA_RS10245
uniprot id: F8EXY2
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

744872:SPICA RS07215
gene id: 744872:SPICA_RS07215
uniprot id: F8F3I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

744872:SPICA RS10260
gene id: 744872:SPICA_RS10260
uniprot id: F8EZC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

744872:SPICA RS01750
gene id: 744872:SPICA_RS01750
uniprot id: F8EWY4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

744872:SPICA RS09620
gene id: 744872:SPICA_RS09620
uniprot id: F8F407
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

744872:SPICA RS04030
gene id: 744872:SPICA_RS04030
uniprot id: F8F084
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

744872:SPICA RS06755
gene id: 744872:SPICA_RS06755
uniprot id: F8F2T0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

744872:SPICA RS12760
gene id: 744872:SPICA_RS12760
uniprot id: F8F4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

744872:SPICA RS04805
gene id: 744872:SPICA_RS04805
uniprot id: F8F2I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

744872:SPICA RS07660
gene id: 744872:SPICA_RS07660
uniprot id: F8EZ59
names: Similarity
messages: Belongs to the aldose epimerase family.

744872:SPICA RS07050
gene id: 744872:SPICA_RS07050
uniprot id: F8F3F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

744872:SPICA RS00100
gene id: 744872:SPICA_RS00100
uniprot id: F8EWN0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

744872:SPICA RS10880
gene id: 744872:SPICA_RS10880
uniprot id: F8F0Y4
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00765
gene id: 744872:SPICA_RS00765
uniprot id: F8EWT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

744872:SPICA RS06950
gene id: 744872:SPICA_RS06950
uniprot id: F8F3D7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

744872:SPICA RS06875
gene id: 744872:SPICA_RS06875
uniprot id: F8F2V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

744872:SPICA RS03215
gene id: 744872:SPICA_RS03215
uniprot id: F8F1E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS04920
gene id: 744872:SPICA_RS04920
uniprot id: F8F2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

744872:SPICA RS13195
gene id: 744872:SPICA_RS13195
uniprot id: F8EY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS07360
gene id: 744872:SPICA_RS07360
uniprot id: F8EXL1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

744872:SPICA RS04655
gene id: 744872:SPICA_RS04655
uniprot id: F8F1L5
names: Similarity
messages: Belongs to the BMP lipoprotein family.

744872:SPICA RS04085
gene id: 744872:SPICA_RS04085
uniprot id: F8F096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

744872:SPICA RS04925
gene id: 744872:SPICA_RS04925
uniprot id: F8F2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

744872:SPICA RS02110
gene id: 744872:SPICA_RS02110
uniprot id: F8EYK6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

744872:SPICA RS02700
gene id: 744872:SPICA_RS02700
uniprot id: F8F040
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS13640
gene id: 744872:SPICA_RS13640
uniprot id: F8EZR5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS02825
gene id: 744872:SPICA_RS02825
uniprot id: F8F064
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

744872:SPICA RS14925
gene id: 744872:SPICA_RS14925
uniprot id: F8EXR3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00770
gene id: 744872:SPICA_RS00770
uniprot id: F8EWT9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

744872:SPICA RS04020
gene id: 744872:SPICA_RS04020
uniprot id: F8F082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

744872:SPICA RS09245
gene id: 744872:SPICA_RS09245
uniprot id: F8F3L0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

744872:SPICA RS02150
gene id: 744872:SPICA_RS02150
uniprot id: F8EYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

744872:SPICA RS13535
gene id: 744872:SPICA_RS13535
uniprot id: F8EZP4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

744872:SPICA RS07225
gene id: 744872:SPICA_RS07225
uniprot id: F8F3I9
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS02310
gene id: 744872:SPICA_RS02310
uniprot id: F8EYN7
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

744872:SPICA RS10735
gene id: 744872:SPICA_RS10735
uniprot id: F8F0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

744872:SPICA RS11970
gene id: 744872:SPICA_RS11970
uniprot id: F8F3U9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

744872:SPICA RS12350
gene id: 744872:SPICA_RS12350
uniprot id: F8F495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

744872:SPICA RS04060
gene id: 744872:SPICA_RS04060
uniprot id: F8F090
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

744872:SPICA RS02515
gene id: 744872:SPICA_RS02515
uniprot id: F8F001
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

744872:SPICA RS02675
gene id: 744872:SPICA_RS02675
uniprot id: F8F035
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

744872:SPICA RS08395
gene id: 744872:SPICA_RS08395
uniprot id: F8F1U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

744872:SPICA RS01940
gene id: 744872:SPICA_RS01940
uniprot id: F8EX19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

744872:SPICA RS00725
gene id: 744872:SPICA_RS00725
uniprot id: F8EWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS02925
gene id: 744872:SPICA_RS02925
uniprot id: F8F193
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

744872:SPICA RS06005
gene id: 744872:SPICA_RS06005
uniprot id: F8F0H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

744872:SPICA RS05620
gene id: 744872:SPICA_RS05620
uniprot id: F8EZ22
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

744872:SPICA RS09780
gene id: 744872:SPICA_RS09780
uniprot id: F8F434
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

744872:SPICA RS13855
gene id: 744872:SPICA_RS13855
uniprot id: F8F143
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

744872:SPICA RS13565
gene id: 744872:SPICA_RS13565
uniprot id: F8EZQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

744872:SPICA RS05555
gene id: 744872:SPICA_RS05555
uniprot id: F8EZ11
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

744872:SPICA RS01540
gene id: 744872:SPICA_RS01540
uniprot id: F8EZV7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

744872:SPICA RS05265
gene id: 744872:SPICA_RS05265
uniprot id: F8EXG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS03955
gene id: 744872:SPICA_RS03955
uniprot id: F8F070
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

744872:SPICA RS01785
gene id: 744872:SPICA_RS01785
uniprot id: F8EWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS12335
gene id: 744872:SPICA_RS12335
uniprot id: F8F493
names: Cofactor
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN covalently per subunit.

744872:SPICA RS01485
gene id: 744872:SPICA_RS01485
uniprot id: F8EZU6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00990
gene id: 744872:SPICA_RS00990
uniprot id: F8EYD7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

744872:SPICA RS02070
gene id: 744872:SPICA_RS02070
uniprot id: F8EX47
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

744872:SPICA RS13930
gene id: 744872:SPICA_RS13930
uniprot id: F8F158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

744872:SPICA RS02045
gene id: 744872:SPICA_RS02045
uniprot id: F8EX41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS11665
gene id: 744872:SPICA_RS11665
uniprot id: F8F384
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

744872:SPICA RS05035
gene id: 744872:SPICA_RS05035
uniprot id: F8F2M8
names: Similarity
messages: Belongs to the hemerythrin family.

744872:SPICA RS01355
gene id: 744872:SPICA_RS01355
uniprot id: F8EZS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

744872:SPICA RS13380
gene id: 744872:SPICA_RS13380
uniprot id: F8EZL3
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

744872:SPICA RS08775
gene id: 744872:SPICA_RS08775
uniprot id: F8F2W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS06730
gene id: 744872:SPICA_RS06730
uniprot id: F8F2S5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14715
gene id: 744872:SPICA_RS14715
uniprot id: F8F1H0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

744872:SPICA RS13655
gene id: 744872:SPICA_RS13655
uniprot id: F8EZR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

744872:SPICA RS15075
gene id: 744872:SPICA_RS15075
uniprot id: F8EXZ2
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

744872:SPICA RS08660
gene id: 744872:SPICA_RS08660
uniprot id: F8F1Z8
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

744872:SPICA RS13810
gene id: 744872:SPICA_RS13810
uniprot id: F8F135
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

744872:SPICA RS09790
gene id: 744872:SPICA_RS09790
uniprot id: F8F436
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

744872:SPICA RS03030
gene id: 744872:SPICA_RS03030
uniprot id: F8F1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS03410
gene id: 744872:SPICA_RS03410
uniprot id: F8EX87
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

744872:SPICA RS10190
gene id: 744872:SPICA_RS10190
uniprot id: F8EXX1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09270
gene id: 744872:SPICA_RS09270
uniprot id: F8F3L5
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

744872:SPICA RS02495
gene id: 744872:SPICA_RS02495
uniprot id: F8EZZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

744872:SPICA RS11280
gene id: 744872:SPICA_RS11280
uniprot id: F8F269
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS10370
gene id: 744872:SPICA_RS10370
uniprot id: F8EZE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

744872:SPICA RS09260
gene id: 744872:SPICA_RS09260
uniprot id: F8F3L3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS10160
gene id: 744872:SPICA_RS10160
uniprot id: F8EXW5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06720
gene id: 744872:SPICA_RS06720
uniprot id: F8F2S3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

744872:SPICA RS04985
gene id: 744872:SPICA_RS04985
uniprot id: F8F2L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

744872:SPICA RS08590
gene id: 744872:SPICA_RS08590
uniprot id: F8F1Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

744872:SPICA RS02470
gene id: 744872:SPICA_RS02470
uniprot id: F8EZZ2
names: Similarity
messages: Belongs to the UPF0102 family.

744872:SPICA RS05930
gene id: 744872:SPICA_RS05930
uniprot id: F8F0G4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

744872:SPICA RS02525
gene id: 744872:SPICA_RS02525
uniprot id: F8F003
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

744872:SPICA RS10660
gene id: 744872:SPICA_RS10660
uniprot id: F8F0T8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

744872:SPICA RS01635
gene id: 744872:SPICA_RS01635
uniprot id: F8EZX6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

744872:SPICA RS03285
gene id: 744872:SPICA_RS03285
uniprot id: F8EX61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS10355
gene id: 744872:SPICA_RS10355
uniprot id: F8EZE5
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

744872:SPICA RS08690
gene id: 744872:SPICA_RS08690
uniprot id: F8F204
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

744872:SPICA RS02060
gene id: 744872:SPICA_RS02060
uniprot id: F8EX45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

744872:SPICA RS08285
gene id: 744872:SPICA_RS08285
uniprot id: F8F0R6
names: Subcellular Location Annotation
messages: Periplasmic flagellum

744872:SPICA RS09965
gene id: 744872:SPICA_RS09965
uniprot id: F8EXS6
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

744872:SPICA RS02090
gene id: 744872:SPICA_RS02090
uniprot id: F8EYK2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS10155
gene id: 744872:SPICA_RS10155
uniprot id: F8EXW4
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06790
gene id: 744872:SPICA_RS06790
uniprot id: F8F2T7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS03545
gene id: 744872:SPICA_RS03545
uniprot id: F8EXB4
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS07085
gene id: 744872:SPICA_RS07085
uniprot id: F8F3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

744872:SPICA RS02535
gene id: 744872:SPICA_RS02535
uniprot id: F8F005
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS06130
gene id: 744872:SPICA_RS06130
uniprot id: F8F0K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

744872:SPICA RS09815
gene id: 744872:SPICA_RS09815
uniprot id: F8F441
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS10645
gene id: 744872:SPICA_RS10645
uniprot id: F8F0T5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

744872:SPICA RS07895
gene id: 744872:SPICA_RS07895
uniprot id: F8EZA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

744872:SPICA RS10540
gene id: 744872:SPICA_RS10540
uniprot id: F8EZI0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

744872:SPICA RS06100
gene id: 744872:SPICA_RS06100
uniprot id: F8F0J9
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

744872:SPICA RS12370
gene id: 744872:SPICA_RS12370
uniprot id: F8F499
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

744872:SPICA RS13710
gene id: 744872:SPICA_RS13710
uniprot id: F8F116
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

744872:SPICA RS08155
gene id: 744872:SPICA_RS08155
uniprot id: F8F0P0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS04330
gene id: 744872:SPICA_RS04330
uniprot id: F8F1F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

744872:SPICA RS00785
gene id: 744872:SPICA_RS00785
uniprot id: F8EWU2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS12545
gene id: 744872:SPICA_RS12545
uniprot id: F8F4D3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

744872:SPICA RS11820
gene id: 744872:SPICA_RS11820
uniprot id: F8F3S0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS10980
gene id: 744872:SPICA_RS10980
uniprot id: F8F218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell inner membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

744872:SPICA RS02005
gene id: 744872:SPICA_RS02005
uniprot id: F8EX32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

744872:SPICA RS03205
gene id: 744872:SPICA_RS03205
uniprot id: F8F1E4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

744872:SPICA RS11670
gene id: 744872:SPICA_RS11670
uniprot id: F8F385
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01245
gene id: 744872:SPICA_RS01245
uniprot id: F8EYI3
names: Similarity
messages: Belongs to the transketolase family.

744872:SPICA RS06635
gene id: 744872:SPICA_RS06635
uniprot id: F8F2Q6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

744872:SPICA RS13475
gene id: 744872:SPICA_RS13475
uniprot id: F8EZN3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

744872:SPICA RS00300
gene id: 744872:SPICA_RS00300
uniprot id: F8EY73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS05940
gene id: 744872:SPICA_RS05940
uniprot id: F8F0G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

744872:SPICA RS04450
gene id: 744872:SPICA_RS04450
uniprot id: F8F1H7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

744872:SPICA RS10400
gene id: 744872:SPICA_RS10400
uniprot id: F8EZF4
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS01580
gene id: 744872:SPICA_RS01580
uniprot id: F8EZW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS01455
gene id: 744872:SPICA_RS01455
uniprot id: F8EZU0
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

744872:SPICA RS12260
gene id: 744872:SPICA_RS12260
uniprot id: F8F478
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS11810
gene id: 744872:SPICA_RS11810
uniprot id: F8F3R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

744872:SPICA RS11230
gene id: 744872:SPICA_RS11230
uniprot id: F8F259
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00435
gene id: 744872:SPICA_RS00435
uniprot id: F8EYA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS02155
gene id: 744872:SPICA_RS02155
uniprot id: F8EYL5
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

744872:SPICA RS00105
gene id: 744872:SPICA_RS00105
uniprot id: F8EWN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

744872:SPICA RS13545
gene id: 744872:SPICA_RS13545
uniprot id: F8EZP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS05590
gene id: 744872:SPICA_RS05590
uniprot id: F8EZ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

744872:SPICA RS01080
gene id: 744872:SPICA_RS01080
uniprot id: F8EYF1
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS12665
gene id: 744872:SPICA_RS12665
uniprot id: F8F4F7
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

744872:SPICA RS12895
gene id: 744872:SPICA_RS12895
uniprot id: F8EXY5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

744872:SPICA RS06645
gene id: 744872:SPICA_RS06645
uniprot id: F8F2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS10390
gene id: 744872:SPICA_RS10390
uniprot id: F8EZF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS00860
gene id: 744872:SPICA_RS00860
uniprot id: F8EWV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS13985
gene id: 744872:SPICA_RS13985
uniprot id: F8F169
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS07690
gene id: 744872:SPICA_RS07690
uniprot id: F8EZ65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS06715
gene id: 744872:SPICA_RS06715
uniprot id: F8F2S2
names: Similarity
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

744872:SPICA RS00895
gene id: 744872:SPICA_RS00895
uniprot id: F8EWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS03875
gene id: 744872:SPICA_RS03875
uniprot id: F8EYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

744872:SPICA RS07205
gene id: 744872:SPICA_RS07205
uniprot id: F8F3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

744872:SPICA RS08265
gene id: 744872:SPICA_RS08265
uniprot id: F8F0R2
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

744872:SPICA RS08570
gene id: 744872:SPICA_RS08570
uniprot id: F8F1Y0
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS07010
gene id: 744872:SPICA_RS07010
uniprot id: F8F3E9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

744872:SPICA RS08130
gene id: 744872:SPICA_RS08130
uniprot id: F8F0N5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

744872:SPICA RS05375
gene id: 744872:SPICA_RS05375
uniprot id: F8EXI3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

744872:SPICA RS02790
gene id: 744872:SPICA_RS02790
uniprot id: F8F057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

744872:SPICA RS06065
gene id: 744872:SPICA_RS06065
uniprot id: F8F0J2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

744872:SPICA RS03035
gene id: 744872:SPICA_RS03035
uniprot id: F8F1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS07040
gene id: 744872:SPICA_RS07040
uniprot id: F8F3F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

744872:SPICA RS03430
gene id: 744872:SPICA_RS03430
uniprot id: F8EX91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

744872:SPICA RS04270
gene id: 744872:SPICA_RS04270
uniprot id: F8F0D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

744872:SPICA RS05065
gene id: 744872:SPICA_RS05065
uniprot id: F8EXC2
names: Similarity
messages: Belongs to the MEMO1 family.

744872:SPICA RS06120
gene id: 744872:SPICA_RS06120
uniprot id: F8F0K3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

744872:SPICA RS04880
gene id: 744872:SPICA_RS04880
uniprot id: F8F2J7
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS13620
gene id: 744872:SPICA_RS13620
uniprot id: F8EZR1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

744872:SPICA RS03280
gene id: 744872:SPICA_RS03280
uniprot id: F8EX60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS02435
gene id: 744872:SPICA_RS02435
uniprot id: F8EYR1
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

744872:SPICA RS08275
gene id: 744872:SPICA_RS08275
uniprot id: F8F0R4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS08185
gene id: 744872:SPICA_RS08185
uniprot id: F8F0P6
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

744872:SPICA RS01770
gene id: 744872:SPICA_RS01770
uniprot id: F8EWY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Homodimer.
messages: Monomer.
messages: Secreted

744872:SPICA RS02025
gene id: 744872:SPICA_RS02025
uniprot id: F8EX37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

744872:SPICA RS13755
gene id: 744872:SPICA_RS13755
uniprot id: F8F125
names: Similarity
messages: Belongs to the threonine aldolase family.

744872:SPICA RS06895
gene id: 744872:SPICA_RS06895
uniprot id: F8F3C6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

744872:SPICA RS09950
gene id: 744872:SPICA_RS09950
uniprot id: F8EXS3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

744872:SPICA RS03990
gene id: 744872:SPICA_RS03990
uniprot id: F8F077
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

744872:SPICA RS00035
gene id: 744872:SPICA_RS00035
uniprot id: F8EWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

744872:SPICA RS12555
gene id: 744872:SPICA_RS12555
uniprot id: F8F4D5
names: Similarity
messages: Belongs to the UPF0166 family.

744872:SPICA RS04810
gene id: 744872:SPICA_RS04810
uniprot id: F8F2I4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

744872:SPICA RS02655
gene id: 744872:SPICA_RS02655
uniprot id: F8F031
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

744872:SPICA RS14355
gene id: 744872:SPICA_RS14355
uniprot id: F8F2E7
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

744872:SPICA RS01000
gene id: 744872:SPICA_RS01000
uniprot id: F8EYD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

744872:SPICA RS01930
gene id: 744872:SPICA_RS01930
uniprot id: F8EX17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

744872:SPICA RS03505
gene id: 744872:SPICA_RS03505
uniprot id: F8EXA6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

744872:SPICA RS00015
gene id: 744872:SPICA_RS00015
uniprot id: F8EWL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

744872:SPICA RS03170
gene id: 744872:SPICA_RS03170
uniprot id: F8F1D7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

744872:SPICA RS04005
gene id: 744872:SPICA_RS04005
uniprot id: F8F080
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

744872:SPICA RS10590
gene id: 744872:SPICA_RS10590
uniprot id: F8EZI7
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

744872:SPICA RS12820
gene id: 744872:SPICA_RS12820
uniprot id: F8F4I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

744872:SPICA RS00845
gene id: 744872:SPICA_RS00845
uniprot id: F8EWV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

744872:SPICA RS01705
gene id: 744872:SPICA_RS01705
uniprot id: F8EZZ0
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

744872:SPICA RS06415
gene id: 744872:SPICA_RS06415
uniprot id: F8F1S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

744872:SPICA RS09690
gene id: 744872:SPICA_RS09690
uniprot id: F8F420
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

744872:SPICA RS13705
gene id: 744872:SPICA_RS13705
uniprot id: F8F115
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

744872:SPICA RS09310
gene id: 744872:SPICA_RS09310
uniprot id: F8F3M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

744872:SPICA RS07770
gene id: 744872:SPICA_RS07770
uniprot id: F8EZ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

744872:SPICA RS02940
gene id: 744872:SPICA_RS02940
uniprot id: F8F196
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01995
gene id: 744872:SPICA_RS01995
uniprot id: F8EX30
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

744872:SPICA RS08115
gene id: 744872:SPICA_RS08115
uniprot id: F8F0N2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

744872:SPICA RS04665
gene id: 744872:SPICA_RS04665
uniprot id: F8F1L7
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01200
gene id: 744872:SPICA_RS01200
uniprot id: F8EYH5
names: Similarity
messages: Belongs to the peptidase S41A family.

744872:SPICA RS13330
gene id: 744872:SPICA_RS13330
uniprot id: F8EZK3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01290
gene id: 744872:SPICA_RS01290
uniprot id: F8EYJ2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS11430
gene id: 744872:SPICA_RS11430
uniprot id: F8F341
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03570
gene id: 744872:SPICA_RS03570
uniprot id: F8EXB9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

744872:SPICA RS10015
gene id: 744872:SPICA_RS10015
uniprot id: F8EXT6
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

744872:SPICA RS10340
gene id: 744872:SPICA_RS10340
uniprot id: F8EZE2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

744872:SPICA RS09330
gene id: 744872:SPICA_RS09330
uniprot id: F8F3M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

744872:SPICA RS01195
gene id: 744872:SPICA_RS01195
uniprot id: F8EYH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

744872:SPICA RS07840
gene id: 744872:SPICA_RS07840
uniprot id: F8EZ94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

744872:SPICA RS04425
gene id: 744872:SPICA_RS04425
uniprot id: F8F1H2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00875
gene id: 744872:SPICA_RS00875
uniprot id: F8EWW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

744872:SPICA RS00345
gene id: 744872:SPICA_RS00345
uniprot id: F8EY82
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

744872:SPICA RS00230
gene id: 744872:SPICA_RS00230
uniprot id: F8EY59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

744872:SPICA RS06445
gene id: 744872:SPICA_RS06445
uniprot id: F8F1S8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

744872:SPICA RS01715
gene id: 744872:SPICA_RS01715
uniprot id: F8EZZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

744872:SPICA RS07250
gene id: 744872:SPICA_RS07250
uniprot id: F8F3J4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

744872:SPICA RS07340
gene id: 744872:SPICA_RS07340
uniprot id: F8EXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

744872:SPICA RS06675
gene id: 744872:SPICA_RS06675
uniprot id: F8F2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

744872:SPICA RS07270
gene id: 744872:SPICA_RS07270
uniprot id: F8EXJ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

744872:SPICA RS10780
gene id: 744872:SPICA_RS10780
uniprot id: F8F0W2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

744872:SPICA RS02510
gene id: 744872:SPICA_RS02510
uniprot id: F8F000
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

744872:SPICA RS12115
gene id: 744872:SPICA_RS12115
uniprot id: F8F3X8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS03825
gene id: 744872:SPICA_RS03825
uniprot id: F8EYW7
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08510
gene id: 744872:SPICA_RS08510
uniprot id: F8F1W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

744872:SPICA RS13735
gene id: 744872:SPICA_RS13735
uniprot id: F8F121
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS13635
gene id: 744872:SPICA_RS13635
uniprot id: F8EZR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

744872:SPICA RS06865
gene id: 744872:SPICA_RS06865
uniprot id: F8F2V2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

744872:SPICA RS05015
gene id: 744872:SPICA_RS05015
uniprot id: F8F2M4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

744872:SPICA RS07630
gene id: 744872:SPICA_RS07630
uniprot id: F8EZ53
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

744872:SPICA RS07060
gene id: 744872:SPICA_RS07060
uniprot id: F8F3F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS02035
gene id: 744872:SPICA_RS02035
uniprot id: F8EX39
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

744872:SPICA RS00420
gene id: 744872:SPICA_RS00420
uniprot id: F8EY97
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

744872:SPICA RS06470
gene id: 744872:SPICA_RS06470
uniprot id: F8F1T3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

744872:SPICA RS10065
gene id: 744872:SPICA_RS10065
uniprot id: F8EXU6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

744872:SPICA RS07930
gene id: 744872:SPICA_RS07930
uniprot id: F8EZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

744872:SPICA RS06855
gene id: 744872:SPICA_RS06855
uniprot id: F8F2V0
names: Similarity
messages: Belongs to the Skp family.

744872:SPICA RS03610
gene id: 744872:SPICA_RS03610
uniprot id: F8EYS4
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

744872:SPICA RS00080
gene id: 744872:SPICA_RS00080
uniprot id: F8EWM6
names: Similarity
messages: Belongs to the peptidase S16 family.

744872:SPICA RS13890
gene id: 744872:SPICA_RS13890
uniprot id: F8F150
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

744872:SPICA RS07855
gene id: 744872:SPICA_RS07855
uniprot id: F8EZ97
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

744872:SPICA RS01775
gene id: 744872:SPICA_RS01775
uniprot id: F8EWY9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

744872:SPICA RS12960
gene id: 744872:SPICA_RS12960
uniprot id: F8EXZ4
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

744872:SPICA RS00800
gene id: 744872:SPICA_RS00800
uniprot id: F8EWU5
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

744872:SPICA RS15560
gene id: 744872:SPICA_RS15560
uniprot id: F8EX94
names: Similarity
messages: Belongs to the UPF0251 family.

744872:SPICA RS06745
gene id: 744872:SPICA_RS06745
uniprot id: F8F2S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

744872:SPICA RS08380
gene id: 744872:SPICA_RS08380
uniprot id: F8F1U3
names: Similarity
messages: Belongs to the P(II) protein family.

744872:SPICA RS07775
gene id: 744872:SPICA_RS07775
uniprot id: F8EZ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

744872:SPICA RS05105
gene id: 744872:SPICA_RS05105
uniprot id: F8EXD0
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

744872:SPICA RS01900
gene id: 744872:SPICA_RS01900
uniprot id: F8EX11
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

744872:SPICA RS06540
gene id: 744872:SPICA_RS06540
uniprot id: F8F2N7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

744872:SPICA RS04670
gene id: 744872:SPICA_RS04670
uniprot id: F8F1L8
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14335
gene id: 744872:SPICA_RS14335
uniprot id: F8F2E4
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

744872:SPICA RS10490
gene id: 744872:SPICA_RS10490
uniprot id: F8EZH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS06840
gene id: 744872:SPICA_RS06840
uniprot id: F8F2U7
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

744872:SPICA RS02395
gene id: 744872:SPICA_RS02395
uniprot id: F8EYQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

744872:SPICA RS10610
gene id: 744872:SPICA_RS10610
uniprot id: F8EZJ1
names: Similarity
messages: Belongs to the LacAB/RpiB family.

744872:SPICA RS07490
gene id: 744872:SPICA_RS07490
uniprot id: F8EXN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

744872:SPICA RS08385
gene id: 744872:SPICA_RS08385
uniprot id: F8F1U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS13055
gene id: 744872:SPICA_RS13055
uniprot id: F8EY12
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

744872:SPICA RS12530
gene id: 744872:SPICA_RS12530
uniprot id: F8F4C9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

744872:SPICA RS09230
gene id: 744872:SPICA_RS09230
uniprot id: F8F3K7
names: Similarity
messages: Belongs to the universal stress protein A family.

744872:SPICA RS01875
gene id: 744872:SPICA_RS01875
uniprot id: F8EX08
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS11740
gene id: 744872:SPICA_RS11740
uniprot id: F8F397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS08550
gene id: 744872:SPICA_RS08550
uniprot id: F8F1X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

744872:SPICA RS12495
gene id: 744872:SPICA_RS12495
uniprot id: F8F4C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

744872:SPICA RS00655
gene id: 744872:SPICA_RS00655
uniprot id: F8EWR6
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

744872:SPICA RS01650
gene id: 744872:SPICA_RS01650
uniprot id: F8EZX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

744872:SPICA RS06170
gene id: 744872:SPICA_RS06170
uniprot id: F8F1M3
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

744872:SPICA RS10795
gene id: 744872:SPICA_RS10795
uniprot id: F8F0W6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

744872:SPICA RS01295
gene id: 744872:SPICA_RS01295
uniprot id: F8EYJ3
names: Subunit
messages: Homodimer.

744872:SPICA RS13895
gene id: 744872:SPICA_RS13895
uniprot id: F8F151
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

744872:SPICA RS01950
gene id: 744872:SPICA_RS01950
uniprot id: F8EX21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

744872:SPICA RS05755
gene id: 744872:SPICA_RS05755
uniprot id: F8EZ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

744872:SPICA RS13100
gene id: 744872:SPICA_RS13100
uniprot id: F8EY21
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

744872:SPICA RS06785
gene id: 744872:SPICA_RS06785
uniprot id: F8F2T6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS10305
gene id: 744872:SPICA_RS10305
uniprot id: F8EZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS01885
gene id: 744872:SPICA_RS01885
uniprot id: F8EX09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

744872:SPICA RS08610
gene id: 744872:SPICA_RS08610
uniprot id: F8F1Y8
names: Subcellular Location Annotation
messages: Periplasmic flagellum

744872:SPICA RS03960
gene id: 744872:SPICA_RS03960
uniprot id: F8F071
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS12870
gene id: 744872:SPICA_RS12870
uniprot id: F8F4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS03965
gene id: 744872:SPICA_RS03965
uniprot id: F8F072
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

744872:SPICA RS03070
gene id: 744872:SPICA_RS03070
uniprot id: F8F1B8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

744872:SPICA RS07940
gene id: 744872:SPICA_RS07940
uniprot id: F8EZB5
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

744872:SPICA RS13840
gene id: 744872:SPICA_RS13840
uniprot id: F8F140
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

744872:SPICA RS02500
gene id: 744872:SPICA_RS02500
uniprot id: F8EZZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

744872:SPICA RS06280
gene id: 744872:SPICA_RS06280
uniprot id: F8F1P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

744872:SPICA RS01680
gene id: 744872:SPICA_RS01680
uniprot id: F8EZY5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

744872:SPICA RS09300
gene id: 744872:SPICA_RS09300
uniprot id: F8F3M1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

744872:SPICA RS14465
gene id: 744872:SPICA_RS14465
uniprot id: F8F3B4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

744872:SPICA RS05165
gene id: 744872:SPICA_RS05165
uniprot id: F8EXE2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

744872:SPICA RS08970
gene id: 744872:SPICA_RS08970
uniprot id: F8F321
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS04160
gene id: 744872:SPICA_RS04160
uniprot id: F8F0A9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

744872:SPICA RS02120
gene id: 744872:SPICA_RS02120
uniprot id: F8EYK8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

744872:SPICA RS04815
gene id: 744872:SPICA_RS04815
uniprot id: F8F2I5
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

744872:SPICA RS08535
gene id: 744872:SPICA_RS08535
uniprot id: F8F1X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

744872:SPICA RS12930
gene id: 744872:SPICA_RS12930
uniprot id: F8EXZ0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

744872:SPICA RS11640
gene id: 744872:SPICA_RS11640
uniprot id: F8F379
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

744872:SPICA RS09265
gene id: 744872:SPICA_RS09265
uniprot id: F8F3L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

744872:SPICA RS09285
gene id: 744872:SPICA_RS09285
uniprot id: F8F3L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

744872:SPICA RS09320
gene id: 744872:SPICA_RS09320
uniprot id: F8F3M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

744872:SPICA RS00980
gene id: 744872:SPICA_RS00980
uniprot id: F8EYD5
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

744872:SPICA RS05030
gene id: 744872:SPICA_RS05030
uniprot id: F8F2M7
names: Similarity
messages: Belongs to the hexokinase family.

744872:SPICA RS13460
gene id: 744872:SPICA_RS13460
uniprot id: F8EZN0
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS05765
gene id: 744872:SPICA_RS05765
uniprot id: F8EZ45
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

744872:SPICA RS06090
gene id: 744872:SPICA_RS06090
uniprot id: F8F0J7
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

744872:SPICA RS06535
gene id: 744872:SPICA_RS06535
uniprot id: F8F2N6
names: Similarity
messages: Belongs to the FemABX family.

744872:SPICA RS01815
gene id: 744872:SPICA_RS01815
uniprot id: F8EWZ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

744872:SPICA RS00050
gene id: 744872:SPICA_RS00050
uniprot id: F8EWL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

744872:SPICA RS12535
gene id: 744872:SPICA_RS12535
uniprot id: F8F4D0
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

744872:SPICA RS07230
gene id: 744872:SPICA_RS07230
uniprot id: F8F3J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

744872:SPICA RS14500
gene id: 744872:SPICA_RS14500
uniprot id: F8F3C1
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

744872:SPICA RS09640
gene id: 744872:SPICA_RS09640
uniprot id: F8F411
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

744872:SPICA RS10960
gene id: 744872:SPICA_RS10960
uniprot id: F8F100
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

744872:SPICA RS04290
gene id: 744872:SPICA_RS04290
uniprot id: F8F0D5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

744872:SPICA RS09295
gene id: 744872:SPICA_RS09295
uniprot id: F8F3M0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS09315
gene id: 744872:SPICA_RS09315
uniprot id: F8F3M4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

744872:SPICA RS05260
gene id: 744872:SPICA_RS05260
uniprot id: F8EXG1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

744872:SPICA RS07890
gene id: 744872:SPICA_RS07890
uniprot id: F8EZA5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

744872:SPICA RS13680
gene id: 744872:SPICA_RS13680
uniprot id: F8F110
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

744872:SPICA RS08640
gene id: 744872:SPICA_RS08640
uniprot id: F8F1Z4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

744872:SPICA RS09970
gene id: 744872:SPICA_RS09970
uniprot id: F8EXS7
names: Similarity
messages: Belongs to the YggT family.

744872:SPICA RS10150
gene id: 744872:SPICA_RS10150
uniprot id: F8EXW3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

744872:SPICA RS01255
gene id: 744872:SPICA_RS01255
uniprot id: F8EYI5
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

744872:SPICA RS10765
gene id: 744872:SPICA_RS10765
uniprot id: F8F0V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS06020
gene id: 744872:SPICA_RS06020
uniprot id: F8F0I2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

744872:SPICA RS10620
gene id: 744872:SPICA_RS10620
uniprot id: F8EZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS06605
gene id: 744872:SPICA_RS06605
uniprot id: F8F2Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

744872:SPICA RS02050
gene id: 744872:SPICA_RS02050
uniprot id: F8EX42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

744872:SPICA RS04715
gene id: 744872:SPICA_RS04715
uniprot id: F8F2G5
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

744872:SPICA RS10045
gene id: 744872:SPICA_RS10045
uniprot id: F8EXU2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13820
gene id: 744872:SPICA_RS13820
uniprot id: F8F137
names: Similarity
messages: Belongs to the sigma-54 factor family.

744872:SPICA RS07080
gene id: 744872:SPICA_RS07080
uniprot id: F8F3G3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

744872:SPICA RS06435
gene id: 744872:SPICA_RS06435
uniprot id: F8F1S6
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

744872:SPICA RS03635
gene id: 744872:SPICA_RS03635
uniprot id: F8EYS8
names: Similarity
messages: Belongs to the UPF0047 family.

744872:SPICA RS03645
gene id: 744872:SPICA_RS03645
uniprot id: F8EYT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

744872:SPICA RS14410
gene id: 744872:SPICA_RS14410
uniprot id: F8F2F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS03540
gene id: 744872:SPICA_RS03540
uniprot id: F8EXB3
names: Similarity
messages: Belongs to the Dps family.

744872:SPICA RS03310
gene id: 744872:SPICA_RS03310
uniprot id: F8EX67
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

744872:SPICA RS02400
gene id: 744872:SPICA_RS02400
uniprot id: F8EYQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

744872:SPICA RS11630
gene id: 744872:SPICA_RS11630
uniprot id: F8F377
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS10730
gene id: 744872:SPICA_RS10730
uniprot id: F8F0V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

744872:SPICA RS08050
gene id: 744872:SPICA_RS08050
uniprot id: F8F0L9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

744872:SPICA RS02375
gene id: 744872:SPICA_RS02375
uniprot id: F8EYQ0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

744872:SPICA RS10050
gene id: 744872:SPICA_RS10050
uniprot id: F8EXU3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

744872:SPICA RS09980
gene id: 744872:SPICA_RS09980
uniprot id: F8EXS9
names: Subcellular Location Annotation
messages: Cytoplasm

744872:SPICA RS03320
gene id: 744872:SPICA_RS03320
uniprot id: F8EX69
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

744872:SPICA RS06380
gene id: 744872:SPICA_RS06380
uniprot id: F8F1R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS10475
gene id: 744872:SPICA_RS10475
uniprot id: F8EZG7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

744872:SPICA RS11600
gene id: 744872:SPICA_RS11600
uniprot id: F8F371
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

744872:SPICA RS07815
gene id: 744872:SPICA_RS07815
uniprot id: F8EZ89
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

744872:SPICA RS10510
gene id: 744872:SPICA_RS10510
uniprot id: F8EZH4
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06570
gene id: 744872:SPICA_RS06570
uniprot id: F8F2P3
names: Similarity
messages: Belongs to the MEMO1 family.

744872:SPICA RS13325
gene id: 744872:SPICA_RS13325
uniprot id: F8EZK2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

744872:SPICA RS08480
gene id: 744872:SPICA_RS08480
uniprot id: F8F1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS11255
gene id: 744872:SPICA_RS11255
uniprot id: F8F264
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS02280
gene id: 744872:SPICA_RS02280
uniprot id: F8EYN1
names: Similarity
messages: Belongs to the disproportionating enzyme family.

744872:SPICA RS03980
gene id: 744872:SPICA_RS03980
uniprot id: F8F075
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS04010
gene id: 744872:SPICA_RS04010
uniprot id: F8F081
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

744872:SPICA RS10975
gene id: 744872:SPICA_RS10975
uniprot id: F8F103
names: Similarity
messages: Belongs to the universal stress protein A family.

744872:SPICA RS02055
gene id: 744872:SPICA_RS02055
uniprot id: F8EX44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

744872:SPICA RS09075
gene id: 744872:SPICA_RS09075
uniprot id: F8F321
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS04650
gene id: 744872:SPICA_RS04650
uniprot id: F8F1L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

744872:SPICA RS08520
gene id: 744872:SPICA_RS08520
uniprot id: F8F1X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

744872:SPICA RS06910
gene id: 744872:SPICA_RS06910
uniprot id: F8F3C9
names: Similarity
messages: Belongs to the peptidase M16 family.

744872:SPICA RS00440
gene id: 744872:SPICA_RS00440
uniprot id: F8EYA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS01230
gene id: 744872:SPICA_RS01230
uniprot id: F8EYI1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

744872:SPICA RS02795
gene id: 744872:SPICA_RS02795
uniprot id: F8F058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

744872:SPICA RS11260
gene id: 744872:SPICA_RS11260
uniprot id: F8F265
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS12150
gene id: 744872:SPICA_RS12150
uniprot id: F8F3Y5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS07635
gene id: 744872:SPICA_RS07635
uniprot id: F8EZ54
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

744872:SPICA RS13860
gene id: 744872:SPICA_RS13860
uniprot id: F8F144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

744872:SPICA RS06900
gene id: 744872:SPICA_RS06900
uniprot id: F8F3C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

744872:SPICA RS01850
gene id: 744872:SPICA_RS01850
uniprot id: F8EX04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.

744872:SPICA RS04410
gene id: 744872:SPICA_RS04410
uniprot id: F8F1G9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

744872:SPICA RS06355
gene id: 744872:SPICA_RS06355
uniprot id: F8F1R0
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

744872:SPICA RS03975
gene id: 744872:SPICA_RS03975
uniprot id: F8F074
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

744872:SPICA RS02530
gene id: 744872:SPICA_RS02530
uniprot id: F8F004
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

744872:SPICA RS10415
gene id: 744872:SPICA_RS10415
uniprot id: F8EZF7
names: Similarity
messages: Belongs to the thioredoxin family.

744872:SPICA RS06385
gene id: 744872:SPICA_RS06385
uniprot id: F8F1R6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

744872:SPICA RS02340
gene id: 744872:SPICA_RS02340
uniprot id: F8EYP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

744872:SPICA RS10855
gene id: 744872:SPICA_RS10855
uniprot id: F8F0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS10270
gene id: 744872:SPICA_RS10270
uniprot id: F8EZC8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

744872:SPICA RS07860
gene id: 744872:SPICA_RS07860
uniprot id: F8EZ98
names: Similarity
messages: Belongs to the aspartokinase family.

744872:SPICA RS00880
gene id: 744872:SPICA_RS00880
uniprot id: F8EWW1
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

744872:SPICA RS06750
gene id: 744872:SPICA_RS06750
uniprot id: F8F2S9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

744872:SPICA RS15565
gene id: 744872:SPICA_RS15565
uniprot id: F8F3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

744872:SPICA RS10055
gene id: 744872:SPICA_RS10055
uniprot id: F8EXU4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

744872:SPICA RS04455
gene id: 744872:SPICA_RS04455
uniprot id: F8F1H8
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

744872:SPICA RS11520
gene id: 744872:SPICA_RS11520
uniprot id: F8F357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

744872:SPICA RS02710
gene id: 744872:SPICA_RS02710
uniprot id: F8F041
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS10025
gene id: 744872:SPICA_RS10025
uniprot id: F8EXT8
names: Similarity
messages: Belongs to the acetyltransferase family. ArgA subfamily.

744872:SPICA RS09170
gene id: 744872:SPICA_RS09170
uniprot id: F8F3J9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

744872:SPICA RS00670
gene id: 744872:SPICA_RS00670
uniprot id: F8EWR9
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

744872:SPICA RS05835
gene id: 744872:SPICA_RS05835
uniprot id: F8F0E6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

744872:SPICA RS14575
gene id: 744872:SPICA_RS14575
uniprot id: F8EWV8
names: Similarity
messages: Belongs to the TrpF family.

744872:SPICA RS14710
gene id: 744872:SPICA_RS14710
uniprot id: F8F1G2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06525
gene id: 744872:SPICA_RS06525
uniprot id: F8F2N4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

744872:SPICA RS01130
gene id: 744872:SPICA_RS01130
uniprot id: F8EYG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS00225
gene id: 744872:SPICA_RS00225
uniprot id: F8EWQ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

744872:SPICA RS12995
gene id: 744872:SPICA_RS12995
uniprot id: F8EY00
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

744872:SPICA RS04770
gene id: 744872:SPICA_RS04770
uniprot id: F8F2H6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08540
gene id: 744872:SPICA_RS08540
uniprot id: F8F1X4
names: Similarity
messages: Belongs to the DprA/Smf family.

744872:SPICA RS09405
gene id: 744872:SPICA_RS09405
uniprot id: F8F3P0
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

744872:SPICA RS12130
gene id: 744872:SPICA_RS12130
uniprot id: F8F3Y1
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

744872:SPICA RS12250
gene id: 744872:SPICA_RS12250
uniprot id: F8F476
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

744872:SPICA RS02210
gene id: 744872:SPICA_RS02210
uniprot id: F8EYM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

744872:SPICA RS06260
gene id: 744872:SPICA_RS06260
uniprot id: F8F1P1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

744872:SPICA RS14535
gene id: 744872:SPICA_RS14535
uniprot id: F8EY83
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS10000
gene id: 744872:SPICA_RS10000
uniprot id: F8EXT3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

744872:SPICA RS04420
gene id: 744872:SPICA_RS04420
uniprot id: F8F1H1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS07785
gene id: 744872:SPICA_RS07785
uniprot id: F8EZ83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

744872:SPICA RS02845
gene id: 744872:SPICA_RS02845
uniprot id: F8F068
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

744872:SPICA RS01510
gene id: 744872:SPICA_RS01510
uniprot id: F8EZV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

744872:SPICA RS08665
gene id: 744872:SPICA_RS08665
uniprot id: F8F1Z9
names: Similarity
messages: Belongs to the UPF0178 family.

744872:SPICA RS08560
gene id: 744872:SPICA_RS08560
uniprot id: F8F1X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

744872:SPICA RS00270
gene id: 744872:SPICA_RS00270
uniprot id: F8EY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

744872:SPICA RS07795
gene id: 744872:SPICA_RS07795
uniprot id: F8EZ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

744872:SPICA RS01990
gene id: 744872:SPICA_RS01990
uniprot id: F8EX29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS09805
gene id: 744872:SPICA_RS09805
uniprot id: F8F439
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

744872:SPICA RS14190
gene id: 744872:SPICA_RS14190
uniprot id: F8F2B6
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

744872:SPICA RS14110
gene id: 744872:SPICA_RS14110
uniprot id: F8F2A2
names: Similarity
messages: Belongs to the ParB family.

744872:SPICA RS11705
gene id: 744872:SPICA_RS11705
uniprot id: F8F391
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS02900
gene id: 744872:SPICA_RS02900
uniprot id: F8F188
names: Similarity
messages: Belongs to the DEAD box helicase family.

744872:SPICA RS14270
gene id: 744872:SPICA_RS14270
uniprot id: F8F2D2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

744872:SPICA RS02690
gene id: 744872:SPICA_RS02690
uniprot id: F8F038
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

744872:SPICA RS14515
gene id: 744872:SPICA_RS14515
uniprot id: F8F3C4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

744872:SPICA RS04825
gene id: 744872:SPICA_RS04825
uniprot id: F8F2I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

744872:SPICA RS10225
gene id: 744872:SPICA_RS10225
uniprot id: F8EXX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

744872:SPICA RS07195
gene id: 744872:SPICA_RS07195
uniprot id: F8F3I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

744872:SPICA RS08525
gene id: 744872:SPICA_RS08525
uniprot id: F8F1X1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

744872:SPICA RS03145
gene id: 744872:SPICA_RS03145
uniprot id: F8F1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS02195
gene id: 744872:SPICA_RS02195
uniprot id: F8EYM3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

744872:SPICA RS11760
gene id: 744872:SPICA_RS11760
uniprot id: F8F3A1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14905
gene id: 744872:SPICA_RS14905
uniprot id: F8F412
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

744872:SPICA RS09160
gene id: 744872:SPICA_RS09160
uniprot id: F8F3J7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

744872:SPICA RS12355
gene id: 744872:SPICA_RS12355
uniprot id: F8F496
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

744872:SPICA RS00240
gene id: 744872:SPICA_RS00240
uniprot id: F8EY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

744872:SPICA RS10845
gene id: 744872:SPICA_RS10845
uniprot id: F8F0X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

744872:SPICA RS04675
gene id: 744872:SPICA_RS04675
uniprot id: F8F1L9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

744872:SPICA RS13900
gene id: 744872:SPICA_RS13900
uniprot id: F8F152
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

744872:SPICA RS04725
gene id: 744872:SPICA_RS04725
uniprot id: F8F2G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

744872:SPICA RS12935
gene id: 744872:SPICA_RS12935
uniprot id: F8EXZ1
names: Function
names: Similarity
messages: Belongs to the PyrI family.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

744872:SPICA RS12550
gene id: 744872:SPICA_RS12550
uniprot id: F8F4D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

744872:SPICA RS01165
gene id: 744872:SPICA_RS01165
uniprot id: F8EYG8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

744872:SPICA RS10850
gene id: 744872:SPICA_RS10850
uniprot id: F8F0X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS01910
gene id: 744872:SPICA_RS01910
uniprot id: F8EX13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

744872:SPICA RS01175
gene id: 744872:SPICA_RS01175
uniprot id: F8EYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS07800
gene id: 744872:SPICA_RS07800
uniprot id: F8EZ86
names: Similarity
messages: Belongs to the MotB family.

744872:SPICA RS04275
gene id: 744872:SPICA_RS04275
uniprot id: F8F0D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

744872:SPICA RS07935
gene id: 744872:SPICA_RS07935
uniprot id: F8EZB4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

744872:SPICA RS05350
gene id: 744872:SPICA_RS05350
uniprot id: F8EXH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS03785
gene id: 744872:SPICA_RS03785
uniprot id: F8EYV9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

744872:SPICA RS12365
gene id: 744872:SPICA_RS12365
uniprot id: F8F498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

744872:SPICA RS13075
gene id: 744872:SPICA_RS13075
uniprot id: F8EY16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

744872:SPICA RS06045
gene id: 744872:SPICA_RS06045
uniprot id: F8F0I8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

744872:SPICA RS00755
gene id: 744872:SPICA_RS00755
uniprot id: F8EWT6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08010
gene id: 744872:SPICA_RS08010
uniprot id: F8F0L1
names: Similarity
messages: Belongs to the Nth/MutY family.

744872:SPICA RS14425
gene id: 744872:SPICA_RS14425
uniprot id: F8F3A6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

744872:SPICA RS01755
gene id: 744872:SPICA_RS01755
uniprot id: F8EWY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

744872:SPICA RS00925
gene id: 744872:SPICA_RS00925
uniprot id: F8EWX0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

744872:SPICA RS08695
gene id: 744872:SPICA_RS08695
uniprot id: F8F205
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

744872:SPICA RS02130
gene id: 744872:SPICA_RS02130
uniprot id: F8EYL0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

744872:SPICA RS07145
gene id: 744872:SPICA_RS07145
uniprot id: F8F3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

744872:SPICA RS00840
gene id: 744872:SPICA_RS00840
uniprot id: F8EWV3
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

744872:SPICA RS04245
gene id: 744872:SPICA_RS04245
uniprot id: F8F0C6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS00815
gene id: 744872:SPICA_RS00815
uniprot id: F8EWU8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

744872:SPICA RS00825
gene id: 744872:SPICA_RS00825
uniprot id: F8EWV0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

744872:SPICA RS05960
gene id: 744872:SPICA_RS05960
uniprot id: F8F0H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

744872:SPICA RS01810
gene id: 744872:SPICA_RS01810
uniprot id: F8EWZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

744872:SPICA RS10965
gene id: 744872:SPICA_RS10965
uniprot id: F8F101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

744872:SPICA RS02590
gene id: 744872:SPICA_RS02590
uniprot id: F8F017
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

744872:SPICA RS11610
gene id: 744872:SPICA_RS11610
uniprot id: F8F373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS14375
gene id: 744872:SPICA_RS14375
uniprot id: F8F2F1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

744872:SPICA RS03695
gene id: 744872:SPICA_RS03695
uniprot id: F8EYU0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

744872:SPICA RS12345
gene id: 744872:SPICA_RS12345
uniprot id: F8F494
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

744872:SPICA RS00290
gene id: 744872:SPICA_RS00290
uniprot id: F8EY71
names: Similarity
messages: Belongs to the Nudix hydrolase family.

744872:SPICA RS00580
gene id: 744872:SPICA_RS00580
uniprot id: F8EYC8
names: Similarity
messages: Belongs to the UPF0303 family.

744872:SPICA RS07140
gene id: 744872:SPICA_RS07140
uniprot id: F8F3H3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

744872:SPICA RS12200
gene id: 744872:SPICA_RS12200
uniprot id: F8F467
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09845
gene id: 744872:SPICA_RS09845
uniprot id: F8F447
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

744872:SPICA RS01920
gene id: 744872:SPICA_RS01920
uniprot id: F8EX15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

744872:SPICA RS06315
gene id: 744872:SPICA_RS06315
uniprot id: F8F1Q2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13395
gene id: 744872:SPICA_RS13395
uniprot id: F8EZL6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09865
gene id: 744872:SPICA_RS09865
uniprot id: F8F451
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

744872:SPICA RS11995
gene id: 744872:SPICA_RS11995
uniprot id: F8F3V4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

744872:SPICA RS08225
gene id: 744872:SPICA_RS08225
uniprot id: F8F0Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

744872:SPICA RS14540
gene id: 744872:SPICA_RS14540
uniprot id: F8EY85
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

744872:SPICA RS12245
gene id: 744872:SPICA_RS12245
uniprot id: F8F475
names: Similarity
messages: Belongs to the SAICAR synthetase family.

744872:SPICA RS13180
gene id: 744872:SPICA_RS13180
uniprot id: F8EY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

744872:SPICA RS10655
gene id: 744872:SPICA_RS10655
uniprot id: F8F0T7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS02170
gene id: 744872:SPICA_RS02170
uniprot id: F8EYL8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

744872:SPICA RS00940
gene id: 744872:SPICA_RS00940
uniprot id: F8EWX3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

744872:SPICA RS02750
gene id: 744872:SPICA_RS02750
uniprot id: F8F049
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS11365
gene id: 744872:SPICA_RS11365
uniprot id: F8F283
names: Similarity
messages: Belongs to the band 7/mec-2 family.

744872:SPICA RS15725
gene id: 744872:SPICA_RS15725
uniprot id: F8EXG0
names: Subcellular Location Annotation
messages: Nucleus

744872:SPICA RS03185
gene id: 744872:SPICA_RS03185
uniprot id: F8F1E0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

744872:SPICA RS12140
gene id: 744872:SPICA_RS12140
uniprot id: F8F3Y3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

744872:SPICA RS09520
gene id: 744872:SPICA_RS09520
uniprot id: F8F3Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS09110
gene id: 744872:SPICA_RS09110
uniprot id: F8F328
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

744872:SPICA RS13185
gene id: 744872:SPICA_RS13185
uniprot id: F8EY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

744872:SPICA RS09725
gene id: 744872:SPICA_RS09725
uniprot id: F8F427
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

744872:SPICA RS03160
gene id: 744872:SPICA_RS03160
uniprot id: F8F1D5
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

744872:SPICA RS13865
gene id: 744872:SPICA_RS13865
uniprot id: F8F145
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

744872:SPICA RS04380
gene id: 744872:SPICA_RS04380
uniprot id: F8F1G3
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

744872:SPICA RS07820
gene id: 744872:SPICA_RS07820
uniprot id: F8EZ90
names: Similarity
messages: Belongs to the FlgD family.

744872:SPICA RS12590
gene id: 744872:SPICA_RS12590
uniprot id: F8F4E2
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

744872:SPICA RS10410
gene id: 744872:SPICA_RS10410
uniprot id: F8EZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

744872:SPICA RS05320
gene id: 744872:SPICA_RS05320
uniprot id: F8EXH3
names: Similarity
messages: Belongs to the UPF0164 family.

744872:SPICA RS09485
gene id: 744872:SPICA_RS09485
uniprot id: F8F3Q7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

744872:SPICA RS11355
gene id: 744872:SPICA_RS11355
uniprot id: F8F281
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03270
gene id: 744872:SPICA_RS03270
uniprot id: F8EX58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS04710
gene id: 744872:SPICA_RS04710
uniprot id: F8F2G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

744872:SPICA RS05690
gene id: 744872:SPICA_RS05690
uniprot id: F8EZ30
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

744872:SPICA RS03290
gene id: 744872:SPICA_RS03290
uniprot id: F8EX62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS00325
gene id: 744872:SPICA_RS00325
uniprot id: F8EY78
names: Function
names: Similarity
messages: Belongs to the UxaE family.
messages: Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).

744872:SPICA RS03925
gene id: 744872:SPICA_RS03925
uniprot id: F8EYY4
names: Similarity
messages: Belongs to the pyruvate kinase family.

744872:SPICA RS05640
gene id: 744872:SPICA_RS05640
uniprot id: F8EZ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

744872:SPICA RS06210
gene id: 744872:SPICA_RS06210
uniprot id: F8F1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

744872:SPICA RS13400
gene id: 744872:SPICA_RS13400
uniprot id: F8EZL7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

744872:SPICA RS01700
gene id: 744872:SPICA_RS01700
uniprot id: F8EZY9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

744872:SPICA RS01925
gene id: 744872:SPICA_RS01925
uniprot id: F8EX16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

744872:SPICA RS10905
gene id: 744872:SPICA_RS10905
uniprot id: F8F0Y9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

744872:SPICA RS03690
gene id: 744872:SPICA_RS03690
uniprot id: F8EYT9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

744872:SPICA RS07915
gene id: 744872:SPICA_RS07915
uniprot id: F8EZB0
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

744872:SPICA RS07000
gene id: 744872:SPICA_RS07000
uniprot id: F8F3E7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

744872:SPICA RS12660
gene id: 744872:SPICA_RS12660
uniprot id: F8F4F6
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

744872:SPICA RS14915
gene id: 744872:SPICA_RS14915
uniprot id: F8F443
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

744872:SPICA RS13965
gene id: 744872:SPICA_RS13965
uniprot id: F8F165
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

744872:SPICA RS14210
gene id: 744872:SPICA_RS14210
uniprot id: F8F2C0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS02320
gene id: 744872:SPICA_RS02320
uniprot id: F8EYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

744872:SPICA RS07910
gene id: 744872:SPICA_RS07910
uniprot id: F8EZA9
names: Similarity
messages: Belongs to the DtxR/MntR family.

744872:SPICA RS00415
gene id: 744872:SPICA_RS00415
uniprot id: F8EY96
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

744872:SPICA RS08360
gene id: 744872:SPICA_RS08360
uniprot id: F8F0T0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

744872:SPICA RS12965
gene id: 744872:SPICA_RS12965
uniprot id: F8EXZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

744872:SPICA RS04250
gene id: 744872:SPICA_RS04250
uniprot id: F8F0C7
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS12695
gene id: 744872:SPICA_RS12695
uniprot id: F8F4G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS09290
gene id: 744872:SPICA_RS09290
uniprot id: F8F3L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

744872:SPICA RS02490
gene id: 744872:SPICA_RS02490
uniprot id: F8EZZ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

744872:SPICA RS01060
gene id: 744872:SPICA_RS01060
uniprot id: F8EYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS05850
gene id: 744872:SPICA_RS05850
uniprot id: F8F0E9
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

744872:SPICA RS13110
gene id: 744872:SPICA_RS13110
uniprot id: F8EY23
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

744872:SPICA RS02685
gene id: 744872:SPICA_RS02685
uniprot id: F8F037
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

744872:SPICA RS12270
gene id: 744872:SPICA_RS12270
uniprot id: F8F480
names: Similarity
messages: Belongs to the GARS family.

744872:SPICA RS05485
gene id: 744872:SPICA_RS05485
uniprot id: F8EZ00
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

744872:SPICA RS10895
gene id: 744872:SPICA_RS10895
uniprot id: F8F0Y7
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08720
gene id: 744872:SPICA_RS08720
uniprot id: F8F210
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

744872:SPICA RS08915
gene id: 744872:SPICA_RS08915
uniprot id: F8F321
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS01515
gene id: 744872:SPICA_RS01515
uniprot id: F8EZV2
names: Similarity
messages: Belongs to the glycosyl hydrolase.

744872:SPICA RS01870
gene id: 744872:SPICA_RS01870
uniprot id: F8EX07
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

744872:SPICA RS07075
gene id: 744872:SPICA_RS07075
uniprot id: F8F3G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

744872:SPICA RS09390
gene id: 744872:SPICA_RS09390
uniprot id: F8F3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

744872:SPICA RS08485
gene id: 744872:SPICA_RS08485
uniprot id: F8F1W3
names: Subcellular Location Annotation
messages: Cytoplasm

744872:SPICA RS06010
gene id: 744872:SPICA_RS06010
uniprot id: F8F0I0
names: Similarity
messages: Belongs to the UPF0237 family.

744872:SPICA RS08530
gene id: 744872:SPICA_RS08530
uniprot id: F8F1X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

744872:SPICA RS06915
gene id: 744872:SPICA_RS06915
uniprot id: F8F3D0
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13875
gene id: 744872:SPICA_RS13875
uniprot id: F8F147
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

744872:SPICA RS07400
gene id: 744872:SPICA_RS07400
uniprot id: F8EXL9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

744872:SPICA RS01460
gene id: 744872:SPICA_RS01460
uniprot id: F8EZU1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS12235
gene id: 744872:SPICA_RS12235
uniprot id: F8F473
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03370
gene id: 744872:SPICA_RS03370
uniprot id: F8EX79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS04490
gene id: 744872:SPICA_RS04490
uniprot id: F8F1I5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

744872:SPICA RS02075
gene id: 744872:SPICA_RS02075
uniprot id: F8EX48
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

744872:SPICA RS05740
gene id: 744872:SPICA_RS05740
uniprot id: F8EZ40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Periplasm
messages: Periplasmic flagellum
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.

744872:SPICA RS05170
gene id: 744872:SPICA_RS05170
uniprot id: F8EXE3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

744872:SPICA RS13025
gene id: 744872:SPICA_RS13025
uniprot id: F8EY06
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

744872:SPICA RS04180
gene id: 744872:SPICA_RS04180
uniprot id: F8F0B3
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

744872:SPICA RS06885
gene id: 744872:SPICA_RS06885
uniprot id: F8F2V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

744872:SPICA RS08580
gene id: 744872:SPICA_RS08580
uniprot id: F8F1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

744872:SPICA RS13695
gene id: 744872:SPICA_RS13695
uniprot id: F8F113
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

744872:SPICA RS06880
gene id: 744872:SPICA_RS06880
uniprot id: F8F2V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

744872:SPICA RS00305
gene id: 744872:SPICA_RS00305
uniprot id: F8EY74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS10020
gene id: 744872:SPICA_RS10020
uniprot id: F8EXT7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

744872:SPICA RS02430
gene id: 744872:SPICA_RS02430
uniprot id: F8EYR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

744872:SPICA RS00140
gene id: 744872:SPICA_RS00140
uniprot id: F8EWN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

744872:SPICA RS06625
gene id: 744872:SPICA_RS06625
uniprot id: F8F2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

744872:SPICA RS03275
gene id: 744872:SPICA_RS03275
uniprot id: F8EX59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS06905
gene id: 744872:SPICA_RS06905
uniprot id: F8F3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

744872:SPICA RS13310
gene id: 744872:SPICA_RS13310
uniprot id: F8EZJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

744872:SPICA RS04525
gene id: 744872:SPICA_RS04525
uniprot id: F8F1J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

744872:SPICA RS06110
gene id: 744872:SPICA_RS06110
uniprot id: F8F0K1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

744872:SPICA RS03365
gene id: 744872:SPICA_RS03365
uniprot id: F8EX78
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

744872:SPICA RS09255
gene id: 744872:SPICA_RS09255
uniprot id: F8F3L2
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

744872:SPICA RS03440
gene id: 744872:SPICA_RS03440
uniprot id: F8EX93
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

744872:SPICA RS05705
gene id: 744872:SPICA_RS05705
uniprot id: F8EZ33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

744872:SPICA RS04505
gene id: 744872:SPICA_RS04505
uniprot id: F8F1I8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS02015
gene id: 744872:SPICA_RS02015
uniprot id: F8EX34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

744872:SPICA RS08330
gene id: 744872:SPICA_RS08330
uniprot id: F8F0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

744872:SPICA RS14235
gene id: 744872:SPICA_RS14235
uniprot id: F8F2C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

744872:SPICA RS09210
gene id: 744872:SPICA_RS09210
uniprot id: F8F3K3
names: Subcellular Location Annotation
messages: Periplasm

744872:SPICA RS12445
gene id: 744872:SPICA_RS12445
uniprot id: F8F4B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS08615
gene id: 744872:SPICA_RS08615
uniprot id: F8F1Y9
names: Subcellular Location Annotation
messages: Periplasmic flagellum

744872:SPICA RS00650
gene id: 744872:SPICA_RS00650
uniprot id: F8EWR5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14395
gene id: 744872:SPICA_RS14395
uniprot id: F8F2F5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09700
gene id: 744872:SPICA_RS09700
uniprot id: F8F422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS06810
gene id: 744872:SPICA_RS06810
uniprot id: F8F2U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

744872:SPICA RS08555
gene id: 744872:SPICA_RS08555
uniprot id: F8F1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

744872:SPICA RS01575
gene id: 744872:SPICA_RS01575
uniprot id: F8EZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS10325
gene id: 744872:SPICA_RS10325
uniprot id: F8EZD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

744872:SPICA RS03330
gene id: 744872:SPICA_RS03330
uniprot id: F8EX71
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

744872:SPICA RS03265
gene id: 744872:SPICA_RS03265
uniprot id: F8EX57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

744872:SPICA RS08430
gene id: 744872:SPICA_RS08430
uniprot id: F8F1V2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS04320
gene id: 744872:SPICA_RS04320
uniprot id: F8F1F2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

744872:SPICA RS07055
gene id: 744872:SPICA_RS07055
uniprot id: F8F3F8
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

744872:SPICA RS02865
gene id: 744872:SPICA_RS02865
uniprot id: F8F181
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

744872:SPICA RS09235
gene id: 744872:SPICA_RS09235
uniprot id: F8F3K8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

744872:SPICA RS13120
gene id: 744872:SPICA_RS13120
uniprot id: F8EY25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

744872:SPICA RS08280
gene id: 744872:SPICA_RS08280
uniprot id: F8F0R5
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

744872:SPICA RS11860
gene id: 744872:SPICA_RS11860
uniprot id: F8F3S8
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

744872:SPICA RS02830
gene id: 744872:SPICA_RS02830
uniprot id: F8F065
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS04685
gene id: 744872:SPICA_RS04685
uniprot id: F8F2F9
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

744872:SPICA RS14340
gene id: 744872:SPICA_RS14340
uniprot id: F8F2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

744872:SPICA RS02720
gene id: 744872:SPICA_RS02720
uniprot id: F8F043
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

744872:SPICA RS09215
gene id: 744872:SPICA_RS09215
uniprot id: F8F3K4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

744872:SPICA RS09880
gene id: 744872:SPICA_RS09880
uniprot id: F8F454
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

744872:SPICA RS02225
gene id: 744872:SPICA_RS02225
uniprot id: F8EYM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

744872:SPICA RS02505
gene id: 744872:SPICA_RS02505
uniprot id: F8EZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

744872:SPICA RS13285
gene id: 744872:SPICA_RS13285
uniprot id: F8EY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS09415
gene id: 744872:SPICA_RS09415
uniprot id: F8F3P2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

744872:SPICA RS02290
gene id: 744872:SPICA_RS02290
uniprot id: F8EYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

744872:SPICA RS14405
gene id: 744872:SPICA_RS14405
uniprot id: F8F2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS06150
gene id: 744872:SPICA_RS06150
uniprot id: F8F0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

744872:SPICA RS04575
gene id: 744872:SPICA_RS04575
uniprot id: F8F1K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS03025
gene id: 744872:SPICA_RS03025
uniprot id: F8F1B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

744872:SPICA RS02305
gene id: 744872:SPICA_RS02305
uniprot id: F8EYN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

744872:SPICA RS00185
gene id: 744872:SPICA_RS00185
uniprot id: F8EWP6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS07615
gene id: 744872:SPICA_RS07615
uniprot id: F8EXR1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

744872:SPICA RS09515
gene id: 744872:SPICA_RS09515
uniprot id: F8F3Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS04510
gene id: 744872:SPICA_RS04510
uniprot id: F8F1I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

744872:SPICA RS10010
gene id: 744872:SPICA_RS10010
uniprot id: F8EXT5
names: Similarity
messages: Belongs to the RecJ family.

744872:SPICA RS06975
gene id: 744872:SPICA_RS06975
uniprot id: F8F3E2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

744872:SPICA RS05955
gene id: 744872:SPICA_RS05955
uniprot id: F8F0G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

744872:SPICA RS06940
gene id: 744872:SPICA_RS06940
uniprot id: F8F3D5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

744872:SPICA RS05295
gene id: 744872:SPICA_RS05295
uniprot id: F8EXG8
names: Similarity
messages: Belongs to the thymidine kinase family.

744872:SPICA RS14785
gene id: 744872:SPICA_RS14785
uniprot id: F8F0H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

744872:SPICA RS08270
gene id: 744872:SPICA_RS08270
uniprot id: F8F0R3
names: Similarity
messages: Belongs to the citrate synthase family.

744872:SPICA RS02520
gene id: 744872:SPICA_RS02520
uniprot id: F8F002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

744872:SPICA RS12455
gene id: 744872:SPICA_RS12455
uniprot id: F8F4B6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

744872:SPICA RS01270
gene id: 744872:SPICA_RS01270
uniprot id: F8EYI8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS12015
gene id: 744872:SPICA_RS12015
uniprot id: F8F3V8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

744872:SPICA RS02760
gene id: 744872:SPICA_RS02760
uniprot id: F8F051
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

744872:SPICA RS14180
gene id: 744872:SPICA_RS14180
uniprot id: F8F2B4
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03325
gene id: 744872:SPICA_RS03325
uniprot id: F8EX70
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

744872:SPICA RS10250
gene id: 744872:SPICA_RS10250
uniprot id: F8EXY3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS04150
gene id: 744872:SPICA_RS04150
uniprot id: F8F0A7
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03725
gene id: 744872:SPICA_RS03725
uniprot id: F8EYU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS05750
gene id: 744872:SPICA_RS05750
uniprot id: F8EZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

744872:SPICA RS03580
gene id: 744872:SPICA_RS03580
uniprot id: F8EYR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

744872:SPICA RS10945
gene id: 744872:SPICA_RS10945
uniprot id: F8F0Z7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS05210
gene id: 744872:SPICA_RS05210
uniprot id: F8EXF1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

744872:SPICA RS07300
gene id: 744872:SPICA_RS07300
uniprot id: F8EXJ9
names: Subcellular Location Annotation
messages: Cytoplasm

744872:SPICA RS04500
gene id: 744872:SPICA_RS04500
uniprot id: F8F1I7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

744872:SPICA RS15000
gene id: 744872:SPICA_RS15000
uniprot id: F8F462
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

744872:SPICA RS11020
gene id: 744872:SPICA_RS11020
uniprot id: F8F227
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

744872:SPICA RS11720
gene id: 744872:SPICA_RS11720
uniprot id: F8F393
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

744872:SPICA RS09240
gene id: 744872:SPICA_RS09240
uniprot id: F8F3K9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

744872:SPICA RS15605
gene id: 744872:SPICA_RS15605
uniprot id: F8EYD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

744872:SPICA RS12360
gene id: 744872:SPICA_RS12360
uniprot id: F8F497
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

744872:SPICA RS07685
gene id: 744872:SPICA_RS07685
uniprot id: F8EZ64
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01915
gene id: 744872:SPICA_RS01915
uniprot id: F8EX14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

744872:SPICA RS00830
gene id: 744872:SPICA_RS00830
uniprot id: F8EWV1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

744872:SPICA RS09580
gene id: 744872:SPICA_RS09580
uniprot id: F8F3Z9
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

744872:SPICA RS10310
gene id: 744872:SPICA_RS10310
uniprot id: F8EZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS03525
gene id: 744872:SPICA_RS03525
uniprot id: F8EXB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS03605
gene id: 744872:SPICA_RS03605
uniprot id: F8EYS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS04265
gene id: 744872:SPICA_RS04265
uniprot id: F8F0D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

744872:SPICA RS01975
gene id: 744872:SPICA_RS01975
uniprot id: F8EX26
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

744872:SPICA RS13275
gene id: 744872:SPICA_RS13275
uniprot id: F8EY54
names: Similarity
messages: Belongs to the threonine synthase family.

744872:SPICA RS10185
gene id: 744872:SPICA_RS10185
uniprot id: F8EXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

744872:SPICA RS05780
gene id: 744872:SPICA_RS05780
uniprot id: F8EZ48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

744872:SPICA RS01405
gene id: 744872:SPICA_RS01405
uniprot id: F8EZT3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

744872:SPICA RS01380
gene id: 744872:SPICA_RS01380
uniprot id: F8EZS9
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

744872:SPICA RS11875
gene id: 744872:SPICA_RS11875
uniprot id: F8F3T1
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

744872:SPICA RS03485
gene id: 744872:SPICA_RS03485
uniprot id: F8EXA2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09600
gene id: 744872:SPICA_RS09600
uniprot id: F8F403
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

744872:SPICA RS07330
gene id: 744872:SPICA_RS07330
uniprot id: F8EXK5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS10990
gene id: 744872:SPICA_RS10990
uniprot id: F8F220
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

744872:SPICA RS04550
gene id: 744872:SPICA_RS04550
uniprot id: F8F1J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS04800
gene id: 744872:SPICA_RS04800
uniprot id: F8F2I2
names: Similarity
messages: Belongs to the aspartokinase family.

744872:SPICA RS03600
gene id: 744872:SPICA_RS03600
uniprot id: F8EYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS02040
gene id: 744872:SPICA_RS02040
uniprot id: F8EX40
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS02000
gene id: 744872:SPICA_RS02000
uniprot id: F8EX31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

744872:SPICA RS10710
gene id: 744872:SPICA_RS10710
uniprot id: F8F0U8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

744872:SPICA RS06655
gene id: 744872:SPICA_RS06655
uniprot id: F8F2R0
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS10350
gene id: 744872:SPICA_RS10350
uniprot id: F8EZE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
messages: Monomer.

744872:SPICA RS13745
gene id: 744872:SPICA_RS13745
uniprot id: F8F123
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01905
gene id: 744872:SPICA_RS01905
uniprot id: F8EX12
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

744872:SPICA RS11415
gene id: 744872:SPICA_RS11415
uniprot id: F8F338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

744872:SPICA RS13530
gene id: 744872:SPICA_RS13530
uniprot id: F8EZP3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

744872:SPICA RS07475
gene id: 744872:SPICA_RS07475
uniprot id: F8EXN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

744872:SPICA RS06345
gene id: 744872:SPICA_RS06345
uniprot id: F8F1Q8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

744872:SPICA RS06015
gene id: 744872:SPICA_RS06015
uniprot id: F8F0I1
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

744872:SPICA RS06970
gene id: 744872:SPICA_RS06970
uniprot id: F8F3E1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

744872:SPICA RS04310
gene id: 744872:SPICA_RS04310
uniprot id: F8F1F0
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

744872:SPICA RS11295
gene id: 744872:SPICA_RS11295
uniprot id: F8F272
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

744872:SPICA RS02065
gene id: 744872:SPICA_RS02065
uniprot id: F8EX46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

744872:SPICA RS13225
gene id: 744872:SPICA_RS13225
uniprot id: F8EY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS05315
gene id: 744872:SPICA_RS05315
uniprot id: F8EXH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

744872:SPICA RS14205
gene id: 744872:SPICA_RS14205
uniprot id: F8F2B9
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13665
gene id: 744872:SPICA_RS13665
uniprot id: F8F104
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

744872:SPICA RS00055
gene id: 744872:SPICA_RS00055
uniprot id: F8EWM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

744872:SPICA RS02665
gene id: 744872:SPICA_RS02665
uniprot id: F8F033
names: Similarity
messages: Belongs to the polysaccharide synthase family.

744872:SPICA RS03120
gene id: 744872:SPICA_RS03120
uniprot id: F8F1C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

744872:SPICA RS11475
gene id: 744872:SPICA_RS11475
uniprot id: F8F349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

744872:SPICA RS07365
gene id: 744872:SPICA_RS07365
uniprot id: F8EXL2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

744872:SPICA RS01980
gene id: 744872:SPICA_RS01980
uniprot id: F8EX27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

744872:SPICA RS10825
gene id: 744872:SPICA_RS10825
uniprot id: F8F0X3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS04950
gene id: 744872:SPICA_RS04950
uniprot id: F8F2L1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

744872:SPICA RS00145
gene id: 744872:SPICA_RS00145
uniprot id: F8EWN8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

744872:SPICA RS04205
gene id: 744872:SPICA_RS04205
uniprot id: F8F0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS14220
gene id: 744872:SPICA_RS14220
uniprot id: F8F2C2
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

744872:SPICA RS08770
gene id: 744872:SPICA_RS08770
uniprot id: F8F2V9
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13540
gene id: 744872:SPICA_RS13540
uniprot id: F8EZP5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS14475
gene id: 744872:SPICA_RS14475
uniprot id: F8F3B6
names: Similarity
messages: Belongs to the peptidase M29 family.

744872:SPICA RS06890
gene id: 744872:SPICA_RS06890
uniprot id: F8F3C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

744872:SPICA RS02020
gene id: 744872:SPICA_RS02020
uniprot id: F8EX36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

744872:SPICA RS00750
gene id: 744872:SPICA_RS00750
uniprot id: F8EWT5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

744872:SPICA RS01945
gene id: 744872:SPICA_RS01945
uniprot id: F8EX20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

744872:SPICA RS08515
gene id: 744872:SPICA_RS08515
uniprot id: F8F1W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

744872:SPICA RS02660
gene id: 744872:SPICA_RS02660
uniprot id: F8F032
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

744872:SPICA RS08750
gene id: 744872:SPICA_RS08750
uniprot id: F8F216
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

744872:SPICA RS04220
gene id: 744872:SPICA_RS04220
uniprot id: F8F0C1
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

744872:SPICA RS04820
gene id: 744872:SPICA_RS04820
uniprot id: F8F2I6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

744872:SPICA RS11965
gene id: 744872:SPICA_RS11965
uniprot id: F8F3U8
names: Similarity
messages: Belongs to the GcvT family.

744872:SPICA RS05695
gene id: 744872:SPICA_RS05695
uniprot id: F8EZ31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasmic flagellum

744872:SPICA RS04025
gene id: 744872:SPICA_RS04025
uniprot id: F8F083
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

744872:SPICA RS04995
gene id: 744872:SPICA_RS04995
uniprot id: F8F2M0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

744872:SPICA RS03670
gene id: 744872:SPICA_RS03670
uniprot id: F8EYT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS09660
gene id: 744872:SPICA_RS09660
uniprot id: F8F414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS08110
gene id: 744872:SPICA_RS08110
uniprot id: F8F0N1
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

744872:SPICA RS11605
gene id: 744872:SPICA_RS11605
uniprot id: F8F372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS01140
gene id: 744872:SPICA_RS01140
uniprot id: F8EYG3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06095
gene id: 744872:SPICA_RS06095
uniprot id: F8F0J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

744872:SPICA RS05010
gene id: 744872:SPICA_RS05010
uniprot id: F8F2M3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

744872:SPICA RS05545
gene id: 744872:SPICA_RS05545
uniprot id: F8EZ09
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

744872:SPICA RS02835
gene id: 744872:SPICA_RS02835
uniprot id: F8F066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

744872:SPICA RS06700
gene id: 744872:SPICA_RS06700
uniprot id: F8F2R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

744872:SPICA RS14240
gene id: 744872:SPICA_RS14240
uniprot id: F8F2C6
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14130
gene id: 744872:SPICA_RS14130
uniprot id: F8F2A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

744872:SPICA RS08335
gene id: 744872:SPICA_RS08335
uniprot id: F8F0S6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

744872:SPICA RS02695
gene id: 744872:SPICA_RS02695
uniprot id: F8F039
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

744872:SPICA RS13080
gene id: 744872:SPICA_RS13080
uniprot id: F8EY17
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

744872:SPICA RS04990
gene id: 744872:SPICA_RS04990
uniprot id: F8F2L9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS07620
gene id: 744872:SPICA_RS07620
uniprot id: F8EXR2
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS07790
gene id: 744872:SPICA_RS07790
uniprot id: F8EZ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

744872:SPICA RS07765
gene id: 744872:SPICA_RS07765
uniprot id: F8EZ79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

744872:SPICA RS11015
gene id: 744872:SPICA_RS11015
uniprot id: F8F226
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

744872:SPICA RS08685
gene id: 744872:SPICA_RS08685
uniprot id: F8F203
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

744872:SPICA RS02085
gene id: 744872:SPICA_RS02085
uniprot id: F8EYK1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03795
gene id: 744872:SPICA_RS03795
uniprot id: F8EYW1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS12750
gene id: 744872:SPICA_RS12750
uniprot id: F8F4H3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS09975
gene id: 744872:SPICA_RS09975
uniprot id: F8EXS8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS04535
gene id: 744872:SPICA_RS04535
uniprot id: F8F1J4
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

744872:SPICA RS11275
gene id: 744872:SPICA_RS11275
uniprot id: F8F268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS04460
gene id: 744872:SPICA_RS04460
uniprot id: F8F1H9
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

744872:SPICA RS10915
gene id: 744872:SPICA_RS10915
uniprot id: F8F0Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS05225
gene id: 744872:SPICA_RS05225
uniprot id: F8EXF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

744872:SPICA RS05285
gene id: 744872:SPICA_RS05285
uniprot id: F8EXG6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

744872:SPICA RS06815
gene id: 744872:SPICA_RS06815
uniprot id: F8F2U2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

744872:SPICA RS12970
gene id: 744872:SPICA_RS12970
uniprot id: F8EXZ6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS12050
gene id: 744872:SPICA_RS12050
uniprot id: F8F3W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

744872:SPICA RS00490
gene id: 744872:SPICA_RS00490
uniprot id: F8EYB0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

744872:SPICA RS00935
gene id: 744872:SPICA_RS00935
uniprot id: F8EWX2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

744872:SPICA RS01955
gene id: 744872:SPICA_RS01955
uniprot id: F8EX22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

744872:SPICA RS08645
gene id: 744872:SPICA_RS08645
uniprot id: F8F1Z5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

744872:SPICA RS06295
gene id: 744872:SPICA_RS06295
uniprot id: F8F1P8
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08135
gene id: 744872:SPICA_RS08135
uniprot id: F8F0N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

744872:SPICA RS06180
gene id: 744872:SPICA_RS06180
uniprot id: F8F1M5
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS13070
gene id: 744872:SPICA_RS13070
uniprot id: F8EY15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS11620
gene id: 744872:SPICA_RS11620
uniprot id: F8F375
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

744872:SPICA RS00025
gene id: 744872:SPICA_RS00025
uniprot id: F8EWL4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

744872:SPICA RS10870
gene id: 744872:SPICA_RS10870
uniprot id: F8F0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS12265
gene id: 744872:SPICA_RS12265
uniprot id: F8F479
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

744872:SPICA RS05630
gene id: 744872:SPICA_RS05630
uniprot id: F8EZ24
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

744872:SPICA RS13560
gene id: 744872:SPICA_RS13560
uniprot id: F8EZP9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS01985
gene id: 744872:SPICA_RS01985
uniprot id: F8EX28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

744872:SPICA RS06530
gene id: 744872:SPICA_RS06530
uniprot id: F8F2N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

744872:SPICA RS04720
gene id: 744872:SPICA_RS04720
uniprot id: F8F2G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

744872:SPICA RS10330
gene id: 744872:SPICA_RS10330
uniprot id: F8EZE0
names: Similarity
messages: Belongs to the fabD family.

744872:SPICA RS02935
gene id: 744872:SPICA_RS02935
uniprot id: F8F195
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS06620
gene id: 744872:SPICA_RS06620
uniprot id: F8F2Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

744872:SPICA RS04210
gene id: 744872:SPICA_RS04210
uniprot id: F8F0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS03150
gene id: 744872:SPICA_RS03150
uniprot id: F8F1D3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

744872:SPICA RS08965
gene id: 744872:SPICA_RS08965
uniprot id: F8F2Z8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

744872:SPICA RS14055
gene id: 744872:SPICA_RS14055
uniprot id: F8F291
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

744872:SPICA RS07640
gene id: 744872:SPICA_RS07640
uniprot id: F8EZ55
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

744872:SPICA RS13870
gene id: 744872:SPICA_RS13870
uniprot id: F8F146
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

744872:SPICA RS02420
gene id: 744872:SPICA_RS02420
uniprot id: F8EYQ9
names: Similarity
messages: Belongs to the acylphosphatase family.

744872:SPICA RS00385
gene id: 744872:SPICA_RS00385
uniprot id: F8EY90
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS08035
gene id: 744872:SPICA_RS08035
uniprot id: F8F0L6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

744872:SPICA RS09325
gene id: 744872:SPICA_RS09325
uniprot id: F8F3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

744872:SPICA RS08595
gene id: 744872:SPICA_RS08595
uniprot id: F8F1Y5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

744872:SPICA RS01820
gene id: 744872:SPICA_RS01820
uniprot id: F8EWZ8
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

744872:SPICA RS00425
gene id: 744872:SPICA_RS00425
uniprot id: F8EY98
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

744872:SPICA RS08495
gene id: 744872:SPICA_RS08495
uniprot id: F8F1W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

744872:SPICA RS09140
gene id: 744872:SPICA_RS09140
uniprot id: F8F331
names: Similarity
messages: Belongs to the creatininase superfamily.

744872:SPICA RS05160
gene id: 744872:SPICA_RS05160
uniprot id: F8EXE1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

744872:SPICA RS12280
gene id: 744872:SPICA_RS12280
uniprot id: F8F482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

744872:SPICA RS08635
gene id: 744872:SPICA_RS08635
uniprot id: F8F1Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

744872:SPICA RS04120
gene id: 744872:SPICA_RS04120
uniprot id: F8F0A1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

744872:SPICA RS10995
gene id: 744872:SPICA_RS10995
uniprot id: F8F222
names: Similarity
messages: Belongs to the RutC family.

744872:SPICA RS07245
gene id: 744872:SPICA_RS07245
uniprot id: F8F3J3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

744872:SPICA RS08060
gene id: 744872:SPICA_RS08060
uniprot id: F8F0M1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

744872:SPICA RS14345
gene id: 744872:SPICA_RS14345
uniprot id: F8F2E6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

744872:SPICA RS00625
gene id: 744872:SPICA_RS00625
uniprot id: F8EWR0
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS01040
gene id: 744872:SPICA_RS01040
uniprot id: F8EYE3
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS02670
gene id: 744872:SPICA_RS02670
uniprot id: F8F034
names: Similarity
messages: Belongs to the archaeal-type GPI family.

744872:SPICA RS01155
gene id: 744872:SPICA_RS01155
uniprot id: F8EYG6
names: Similarity
messages: Belongs to the PspA/IM30 family.

744872:SPICA RS09345
gene id: 744872:SPICA_RS09345
uniprot id: F8F3N0
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

744872:SPICA RS11455
gene id: 744872:SPICA_RS11455
uniprot id: F8F346
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

744872:SPICA RS15090
gene id: 744872:SPICA_RS15090
uniprot id: F8EZK8
names: Similarity
messages: Belongs to the peptidase C40 family.

744872:SPICA RS14450
gene id: 744872:SPICA_RS14450
uniprot id: F8F3B1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS03730
gene id: 744872:SPICA_RS03730
uniprot id: F8EYU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

744872:SPICA RS04520
gene id: 744872:SPICA_RS04520
uniprot id: F8F1J1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

744872:SPICA RS06830
gene id: 744872:SPICA_RS06830
uniprot id: F8F2U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

744872:SPICA RS08445
gene id: 744872:SPICA_RS08445
uniprot id: F8F1V5
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate ammonia-lyase family.
messages: Homodimer.

744872:SPICA RS11405
gene id: 744872:SPICA_RS11405
uniprot id: F8F336
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

744872:SPICA RS07200
gene id: 744872:SPICA_RS07200
uniprot id: F8F3I4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

744872:SPICA RS03255
gene id: 744872:SPICA_RS03255
uniprot id: F8EX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

744872:SPICA RS09785
gene id: 744872:SPICA_RS09785
uniprot id: F8F435
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

744872:SPICA RS00010
gene id: 744872:SPICA_RS00010
uniprot id: F8EWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

744872:SPICA RS06460
gene id: 744872:SPICA_RS06460
uniprot id: F8F1T1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

744872:SPICA RS07755
gene id: 744872:SPICA_RS07755
uniprot id: F8EZ77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

744872:SPICA RS12375
gene id: 744872:SPICA_RS12375
uniprot id: F8F4A0
names: Cofactor
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

744872:SPICA RS08150
gene id: 744872:SPICA_RS08150
uniprot id: F8F0N9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

744872:SPICA RS04735
gene id: 744872:SPICA_RS04735
uniprot id: F8F2G9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

744872:SPICA RS06175
gene id: 744872:SPICA_RS06175
uniprot id: F8F1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

744872:SPICA RS02080
gene id: 744872:SPICA_RS02080
uniprot id: F8EX50
names: Similarity
messages: Belongs to the leucine-binding protein family.

744872:SPICA RS12210
gene id: 744872:SPICA_RS12210
uniprot id: F8F469
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

744872:SPICA RS10705
gene id: 744872:SPICA_RS10705
uniprot id: F8F0U7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS14400
gene id: 744872:SPICA_RS14400
uniprot id: F8F2F6
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

744872:SPICA RS06025
gene id: 744872:SPICA_RS06025
uniprot id: F8F0I3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

744872:SPICA RS09655
gene id: 744872:SPICA_RS09655
uniprot id: F8F413
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

744872:SPICA RS07550
gene id: 744872:SPICA_RS07550
uniprot id: F8EXP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

744872:SPICA RS12755
gene id: 744872:SPICA_RS12755
uniprot id: F8F4H4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

744872:SPICA RS11685
gene id: 744872:SPICA_RS11685
uniprot id: F8F388
names: Similarity
messages: Belongs to the HepT RNase toxin family.

744872:SPICA RS05370
gene id: 744872:SPICA_RS05370
uniprot id: F8EXI2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

744872:SPICA RS02175
gene id: 744872:SPICA_RS02175
uniprot id: F8EYL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

744872:SPICA RS13260
gene id: 744872:SPICA_RS13260
uniprot id: F8EY51
names: Similarity
messages: Belongs to the disproportionating enzyme family.

744872:SPICA RS13465
gene id: 744872:SPICA_RS13465
uniprot id: F8EZN1
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS02805
gene id: 744872:SPICA_RS02805
uniprot id: F8F060
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS14040
gene id: 744872:SPICA_RS14040
uniprot id: F8F288
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

744872:SPICA RS01835
gene id: 744872:SPICA_RS01835
uniprot id: F8EX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

744872:SPICA RS04495
gene id: 744872:SPICA_RS04495
uniprot id: F8F1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

744872:SPICA RS02030
gene id: 744872:SPICA_RS02030
uniprot id: F8EX38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

744872:SPICA RS03515
gene id: 744872:SPICA_RS03515
uniprot id: F8EXA8
names: Subcellular Location Annotation
messages: Membrane

744872:SPICA RS11470
gene id: 744872:SPICA_RS11470
uniprot id: F8F348
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

744872:SPICA RS08575
gene id: 744872:SPICA_RS08575
uniprot id: F8F1Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

744872:SPICA RS03050
gene id: 744872:SPICA_RS03050
uniprot id: F8F1B6
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

744872:SPICA RS06160
gene id: 744872:SPICA_RS06160
uniprot id: F8F1M1
names: Function
names: Similarity
names: Subunit
messages: Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

744872:SPICA RS13115
gene id: 744872:SPICA_RS13115
uniprot id: F8EY24
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.