7227:Dmel CG33891
gene id: 7227:Dmel_CG33891
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG2525
gene id: 7227:Dmel_CG2525
uniprot id: Q9VN60
names: Similarity
messages: Belongs to the HUS1 family.

7227:Dmel CG7654
gene id: 7227:Dmel_CG7654
uniprot id: Q95RF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG3425
gene id: 7227:Dmel_CG3425
uniprot id: Q9W265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
messages: Mitochondrion

7227:Dmel CG17871
gene id: 7227:Dmel_CG17871
uniprot id: M9NFD3
uniprot id: Q9VUK5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG5655
gene id: 7227:Dmel_CG5655
uniprot id: Q24491
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: May control important aspects of development.
messages: Nucleus

7227:Dmel CG33635
gene id: 7227:Dmel_CG33635
uniprot id: Q6II06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

7227:Dmel CG8936
gene id: 7227:Dmel_CG8936
uniprot id: A8JV29
uniprot id: Q9VX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

7227:Dmel CG3234
gene id: 7227:Dmel_CG3234
uniprot id: A0A1W5PW00
uniprot id: P49021
names: Disruption Phenotype
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the timeless family.
messages: Expressed in head, photoreceptors, lateral neurons and glial cells in the lamina and medulla of the optic lobes. Expression follows a light-dark cycle, levels show a significant decrease at the end of the night and then remain low throughout the light period (at protein level).
messages: Forms a heterodimer with period (PER); the complex then translocates into the nucleus.
messages: Intron retention.
messages: Mutant flies show loss of both behavioral circadian rhythms and molecular oscillations of per RNA and protein.
messages: Nucleus
messages: Phosphorylated with a circadian rhythmicity.
messages: Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.
messages: perinuclear region

7227:Dmel CG5887
gene id: 7227:Dmel_CG5887
uniprot id: Q7K4Y0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG13389
gene id: 7227:Dmel_CG13389
uniprot id: Q03334
uniprot id: X2J950
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

7227:Dmel CG7694
gene id: 7227:Dmel_CG7694
uniprot id: Q9VE61
names: Function
names: Similarity
messages: Belongs to the RNF181 family.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

7227:Dmel CG8258
gene id: 7227:Dmel_CG8258
uniprot id: Q7K3J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7227:Dmel CG11201
gene id: 7227:Dmel_CG11201
uniprot id: Q9VM92
names: Function
names: Subcellular Location Annotation
messages: Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis.
messages: Nucleus
messages: cytoskeleton

7227:Dmel CG17178
gene id: 7227:Dmel_CG17178
uniprot id: Q9VK50
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Expressed in labella.
messages: Membrane
messages: RNAi-mediated knockdown in sugar gustatory neurons does not affect sucrose response.

7227:Dmel CG3169
gene id: 7227:Dmel_CG3169
uniprot id: Q9VGE2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7562
gene id: 7227:Dmel_CG7562
uniprot id: Q27896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcription factor. Binds to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Belongs to the TBP family.
messages: May be essential for embryonic development.
messages: Nucleus
messages: Primary spermatocytes in the adult testis and in a subset of cells in the dorsal medial region of the embryonic CNS.

7227:Dmel CG7735
gene id: 7227:Dmel_CG7735
uniprot id: A0A0B4LFW0
uniprot id: A1ZBK9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7227:Dmel CG2830
gene id: 7227:Dmel_CG2830
uniprot id: Q9VPS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chaperonin (HSP60) family.
messages: Mitochondrion matrix
messages: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.

7227:Dmel CG12001
gene id: 7227:Dmel_CG12001
uniprot id: Q9VN45
names: Disruption Phenotype
names: Function
names: RNA Editing
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.
messages: Early endosome
messages: Expressed in larval brain, ventral nerve cord and neuropil (at protein level).
messages: Interacts with Eps-15 (via C-terminal region); the interaction is required for spartin localization to the NMJ presynaptic membrane.
messages: Lipid droplet
messages: Mutant larvae show an overgrowth of the third-instar NMJ, with an overall bouton number and satellite bouton number increase of 40% and 90%, respectively, compared with wild type. Mutant larvae also show a decrease in the amplitude of evoked excitatory junction currents (EJCs), but normal spontaneous miniature EJCs (mEJCs) and axonal transport. Adult mutants display reduced locomotor activity and progressive vacuolization in the brain, which is associated with neurodegeneration.
messages: Partially edited. Target of Adar.
messages: Presynaptic cell membrane

7227:Dmel CG10601
gene id: 7227:Dmel_CG10601
uniprot id: M9PI45
uniprot id: Q9VU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7227:Dmel CG10679
gene id: 7227:Dmel_CG10679
uniprot id: Q9VJ33
uniprot id: X2J935
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cleavage of precursor form is necessary for function.
messages: Covalently attached to cullins.
messages: Flies die from growth arrest in the first-instar larval stage.
messages: Nucleus
messages: Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

7227:Dmel CG3809
gene id: 7227:Dmel_CG3809
uniprot id: Q8T3U8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

7227:Dmel CG11323
gene id: 7227:Dmel_CG11323
uniprot id: Q9VM91
names: Function
names: Subcellular Location Annotation
messages: Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains.
messages: cytoskeleton

7227:Dmel CG10731
gene id: 7227:Dmel_CG10731
uniprot id: A1ZAA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

7227:Dmel CG1885
gene id: 7227:Dmel_CG1885
uniprot id: Q9W3B3
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

7227:Dmel CG9113
gene id: 7227:Dmel_CG9113
uniprot id: Q7KVR7
uniprot id: Q7KVR8
uniprot id: Q86B59
uniprot id: Q9W388
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7227:Dmel CG10176
gene id: 7227:Dmel_CG10176
uniprot id: Q9VJ83
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for egr. Plays a role in activation of JNK signaling and is required for egr-induced apoptosis. May also play an egr-independent role in cell proliferation.
messages: Apical cell membrane
messages: Interacts with egr, Traf6/TRAF2 and veli (via PDZ domain).
messages: The name 'grindelwald' comes from the village at the foot of the Eiger mountain in Switzerland after which the egr gene is named.

7227:Dmel CG1826
gene id: 7227:Dmel_CG1826
uniprot id: Q9W2S3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adults display increased motor activity during locomotion, fragmented sleep and a decreased lifespan. Walking speed is not effected however flies spend more time moving with slightly fewer pauses resulting in longer uninterrupted bouts of walking. The total duration of sleep is not effected but average sleep bout length is decreased, the number of sleep bouts is increased and the amount of wake after sleep onset (WASO) is also increased. Dopamine levels are decreased by 50%. No effect on flight or climbing (negative geotaxis). RNAi-mediated knockdown in a large subset of dopaminergic neurons also results in fragmented sleep.
messages: Cytoplasm
messages: Detected in the brain (at protein level).
messages: Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis.
messages: Expressed in larval muscles.

7227:Dmel CG5535
gene id: 7227:Dmel_CG5535
uniprot id: Q7KUR6
uniprot id: Q9VVM0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG14991
gene id: 7227:Dmel_CG14991
uniprot id: Q9VZI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kindlin family.
messages: Cytoplasm
messages: Probably involved in cell adhesion.
messages: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

7227:Dmel CG8666
gene id: 7227:Dmel_CG8666
uniprot id: Q9VID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG11209
gene id: 7227:Dmel_CG11209
uniprot id: Q86LH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG1772
gene id: 7227:Dmel_CG1772
uniprot id: Q7JNL9
names: Similarity
messages: Belongs to the CDI family.

7227:Dmel CG9706
gene id: 7227:Dmel_CG9706
uniprot id: Q9VVA1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4153
gene id: 7227:Dmel_CG4153
uniprot id: F3YDB2
uniprot id: P41375
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region.

7227:Dmel CG3526
gene id: 7227:Dmel_CG3526
uniprot id: Q8IRV4
uniprot id: Q9W4V2
names: Function
names: Similarity
messages: Belongs to the KCMF1 family.
messages: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

7227:Dmel CG13279
gene id: 7227:Dmel_CG13279
uniprot id: P19967
names: Function
names: Tissue Specificity
messages: May play a role in muscle cell metabolism.
messages: Muscle.

7227:Dmel CG8083
gene id: 7227:Dmel_CG8083
uniprot id: A1Z7N2
uniprot id: Q7K4A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

7227:Dmel CG7686
gene id: 7227:Dmel_CG7686
uniprot id: Q7KN79
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTV1 family.
messages: Cytoplasm
messages: Expressed in the larval body and salivary glands.
messages: Interacts with RpS3; the interaction is RNA-independent. Associates with free 40S ribosome subunits.
messages: Lethal at the second larval stage because of defects in pre-rRNA processing. RNAi-mediated knockdown in fat body cells results in accumulation of RpS2 and the pre-40S ribosome in the nucleus and overall decreased cell and nucleus size. RNAi-mediated knockdown in wing imaginal disk results in caspase-dependent cell-death.
messages: Necessary for the biogenesis of 40S ribosome subunits by regulating pre-rRNA processing. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Necessary for endoreplication driven by Myc.

7227:Dmel CG33844
gene id: 7227:Dmel_CG33844
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG4301
gene id: 7227:Dmel_CG4301
uniprot id: M9NEK4
uniprot id: M9NGI1
uniprot id: Q9VXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7227:Dmel CG12756
gene id: 7227:Dmel_CG12756
uniprot id: Q9VRN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the Enok complex composed of at least Br140, enok, Eaf6 and Ing5.
messages: Component of the Enok complex which has a histone H3 acetyltransferase activity (PubMed:27198229). Might be involved in transcriptional activation of selected genes (PubMed:33926075).
messages: Nucleus
messages: RNAi-mediated knockdown results in early lethality.

7227:Dmel CG6642
gene id: 7227:Dmel_CG6642
uniprot id: Q27377
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antenna. In the third antennal segment. Expressed in sencilla coeloconica.
messages: Belongs to the insect A10/OS-D protein family.
messages: Expressed in adult but not in larval olfactory organs.
messages: Secreted

7227:Dmel CG13480
gene id: 7227:Dmel_CG13480
uniprot id: P81829
names: Function
names: Subcellular Location Annotation
messages: Acts through intracellular calcium in Malpighian tubule stellate cells to raise chloride conductance.
messages: Secreted

7227:Dmel CG18065
gene id: 7227:Dmel_CG18065
uniprot id: A1ZBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

7227:Dmel CG7227
gene id: 7227:Dmel_CG7227
uniprot id: Q9VLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG3732
gene id: 7227:Dmel_CG3732
uniprot id: Q9W230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus

7227:Dmel CG15553
gene id: 7227:Dmel_CG15553
uniprot id: Q9VA14
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9468
gene id: 7227:Dmel_CG9468
uniprot id: Q9VLH9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG1458
gene id: 7227:Dmel_CG1458
uniprot id: Q9VAM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane

7227:Dmel CG8946
gene id: 7227:Dmel_CG8946
uniprot id: Q9V7Y2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
messages: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Expression is high in early and late embryos, and then again early in metamorphosis, followed by reduction to basal levels after eclosion of adult flies in both males and females.
messages: Flies lacking Sply display decreased viability associated with altered nephrocytes morphology. Altered lipid metabolism with accumulation of sphingosine-1-phosphate upstream intermediates is observed.
messages: Localized to the developing gut primordium during embryogenesis.

7227:Dmel CG12781
gene id: 7227:Dmel_CG12781
uniprot id: A0A0B4K7Z1
uniprot id: Q9W1X5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17867
gene id: 7227:Dmel_CG17867
uniprot id: E2E510
uniprot id: Q9VYZ1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters, and specifically to ethyl hexanoate, benzaldehyde, and acetophenone.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG18317
gene id: 7227:Dmel_CG18317
uniprot id: M9ND06
uniprot id: M9NDD0
uniprot id: Q9VQ37
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Larval lethal at the third instar stage. Third-instar larva are decreased in size and display reduced locomotion activity. In third stage larvae body wall preparations, mitochondria are abnormally shaped, disorganized and have a significantly higher density. Oxygen consumption rate (i.e. mitochondrial respiration) is also significantly lower than the controls.
messages: Membrane
messages: Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration.
messages: Mitochondrion
messages: Mitochondrion inner membrane

7227:Dmel CG30156
gene id: 7227:Dmel_CG30156
uniprot id: Q5U0V4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7224
gene id: 7227:Dmel_CG7224
uniprot id: A0A1B3Q3M8
uniprot id: Q9VLU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF4 family.
messages: Interacts with SdhA in its FAD-bound form.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SdhA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SdhB into the SDH catalytic dimer (By similarity).

7227:Dmel CG7140
gene id: 7227:Dmel_CG7140
uniprot id: Q9VNW4
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
messages: Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.

7227:Dmel CG1275
gene id: 7227:Dmel_CG1275
uniprot id: Q7KV99
uniprot id: Q9I7U1
uniprot id: Q9I7U2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6028
gene id: 7227:Dmel_CG6028
uniprot id: Q95SI7
names: Similarity
messages: Belongs to the FAH family.

7227:Dmel CG7804
gene id: 7227:Dmel_CG7804
uniprot id: Q9VUN2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG6938
gene id: 7227:Dmel_CG6938
uniprot id: M9PI24
uniprot id: Q9VTS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG10242
gene id: 7227:Dmel_CG10242
uniprot id: B5RJL8
uniprot id: Q9V771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG9999
gene id: 7227:Dmel_CG9999
uniprot id: Q9VIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RNA1 family.
messages: Both full-length and truncated protein are expressed in testis (at protein level) (PubMed:10073941). Expressed in oocytes and nurse cells (at protein level) (PubMed:31626769).
messages: Cytoplasm
messages: Forms a complex with Nup358/RanBP2, sbr/Nxf1 and Nxt1 (PubMed:14729961). Associates with the nuclear pore complex via its interaction with Nup358/RanBP2 (PubMed:14729961, PubMed:17032737).
messages: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).
messages: Nucleus membrane

7227:Dmel CG15084
gene id: 7227:Dmel_CG15084
uniprot id: Q7K0F0
names: Similarity
messages: Belongs to the CWC16 family.

7227:Dmel CG13517
gene id: 7227:Dmel_CG13517
uniprot id: Q86BF9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PBP/GOBP family.
messages: Expressed in non-neuronal cells in hygrosensitive sensilla in the second chamber of the sacculus of the antenna third segment (at protein level).
messages: Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla.
messages: Secreted
messages: Viable with no morphological, mobility or chemosensory response defects (PubMed:30230472). Results in defective hygrotaxis behavior which might be related to increased desiccation resistance and overall longer lifespan (PubMed:30230472).

7227:Dmel CG3626
gene id: 7227:Dmel_CG3626
uniprot id: Q9W4K8
names: Similarity
messages: Belongs to the GcvT family.

7227:Dmel CG14813
gene id: 7227:Dmel_CG14813
uniprot id: Q7K7G0
uniprot id: Q9W555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

7227:Dmel CG8711
gene id: 7227:Dmel_CG8711
uniprot id: Q5BI50
names: Similarity
messages: Belongs to the cullin family.

7227:Dmel CG9048
gene id: 7227:Dmel_CG9048
uniprot id: M9PCA1
uniprot id: P11449
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the vitelline membrane protein family.
messages: Expressed during vitelline membrane biosynthesis.
messages: Follicle cells.
messages: Major early eggshell protein.
messages: Secreted

7227:Dmel CG18729
gene id: 7227:Dmel_CG18729
uniprot id: Q9VA00
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex composed of rod, Zw10 and Zwilch.
messages: Cytoplasm
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:15886105, PubMed:17576797). Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed:15886105, PubMed:17576797). Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex (PubMed:22685323). Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments (PubMed:22685323).
messages: Lagging chromosomes at anaphase and precocious sister chromatid separation upon activation of the spindle checkpoint (PubMed:12686595). In spermatocytes the number of Golgi structures are not affected but they show a mild defect in shape (PubMed:22685323).
messages: kinetochore
messages: spindle

7227:Dmel CG10219
gene id: 7227:Dmel_CG10219
uniprot id: Q9VCI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

7227:Dmel CG10103
gene id: 7227:Dmel_CG10103
uniprot id: M9PBS9
uniprot id: M9PEC1
uniprot id: M9PEJ2
uniprot id: M9PES8
uniprot id: M9PHL4
uniprot id: Q9VRY6
names: Similarity
messages: Belongs to the IST1 family.

7227:Dmel CG6348
gene id: 7227:Dmel_CG6348
uniprot id: P10181
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in cells within, and posterior to, the morphogenetic furrow of the eye imaginal disk, expression is rapidly restricted to the R2, R3, R4, and R5 precursor cells.
messages: Nucleus
messages: R2 and R5 fail to be correctly determined and appear to be transformed into cells of the R3/4/1/6 subtype.
messages: Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk. Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination.

7227:Dmel CG11858
gene id: 7227:Dmel_CG11858
uniprot id: Q9VBU4
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

7227:Dmel CG14408
gene id: 7227:Dmel_CG14408
uniprot id: B7Z0Y5
uniprot id: Q8IR46
uniprot id: Q9VY16
uniprot id: X2JF03
names: Similarity
messages: Belongs to the SH3BP5 family.

7227:Dmel CG18445
gene id: 7227:Dmel_CG18445
uniprot id: Q6NN55
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Oysgedart' is a Yiddish word meaning skinny, chosen because of this protein's role in phospholipid synthesis.
messages: Acyltransferase with broad-specificity, that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), also lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphochethanolamine or LPE) to phosphatidylchethanolamine (LPEAT activity) and lysophosphatidylglycerol (1-acyl-2-hydroxy-sn-glycero-3-phospho-(1'-sn-glycerol) or LPG) to phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) or PG) (LPGAT activity). Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature. Essential for fertility and viability together with Nessy protein (Nes).
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum
messages: Membrane

7227:Dmel CG8635
gene id: 7227:Dmel_CG8635
uniprot id: A0A0B4LEV3
uniprot id: Q7JWR9
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

7227:Dmel CG7582
gene id: 7227:Dmel_CG7582
uniprot id: A0A0B4K6T8
uniprot id: Q9VAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

7227:Dmel CG33837
gene id: 7227:Dmel_CG33837
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG5097
gene id: 7227:Dmel_CG5097
uniprot id: A0A1B3Q3M0
uniprot id: Q9VDN2
names: Domain
names: Function
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 5 family.
messages: This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity).

7227:Dmel CG12096
gene id: 7227:Dmel_CG12096
uniprot id: Q9VYG1
uniprot id: X2JBJ9
names: Function
names: Similarity
names: Subunit
messages: Acts as a chaperone during the assembly of the 26S proteasome.
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Interacts with PI31; this interaction is increased by PI31 ADP-ribosylation. Interacts with Rpt2.

7227:Dmel CG31478
gene id: 7227:Dmel_CG31478
uniprot id: Q9VF89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG31089
gene id: 7227:Dmel_CG31089
uniprot id: Q9VBK6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG7486
gene id: 7227:Dmel_CG7486
uniprot id: Q8IRY7
uniprot id: X2JHT0
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C14A family.
messages: Constitutively expressed in fat bodies of larvae and adults.
messages: Cytoplasm
messages: Effector of the programmed cell death (PCD) activators rpr, grim and hid (PubMed:9740659). May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (PubMed:10934188). Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection (PubMed:11269502). Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA (PubMed:22549468).
messages: Expressed both maternally and zygotically. Embryos exhibit ubiquitous low level of expression until stage 11 and then expression becomes spatially and temporally restricted to areas of PCD.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit (PubMed:9740659). Interacts (via N-terminus) with Diap2; likely to bind Diap2 simultaneously with Fadd to form a trimeric complex (PubMed:10934188, PubMed:22549468).
messages: Polyubiquitinated by Diap2 following activation of the immune deficiency (Imd) pathway.

7227:Dmel CG12217
gene id: 7227:Dmel_CG12217
uniprot id: M9PGI3
uniprot id: Q27884
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Expressed at highest levels in 2-4 hours embryos.
messages: May be involved in controlling cellularization or in regulating transcription of the genes involved in this process.

7227:Dmel CG14987
gene id: 7227:Dmel_CG14987
uniprot id: Q9VZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.

7227:Dmel CG33838
gene id: 7227:Dmel_CG33838
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG1817
gene id: 7227:Dmel_CG1817
uniprot id: P35992
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
messages: Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars.
messages: In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts.
messages: May have a role in axon outgrowth and guidance.
messages: Membrane
messages: This protein is translated by readthrough of a stop codon. Readthrough of the terminator codon TAG occurs between the codons for Arg-1631 and His-1633. There is currently no sequence that provides the identity of residue 1632.

7227:Dmel CG1689
gene id: 7227:Dmel_CG1689
uniprot id: Q27J10
uniprot id: Q9W349
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the pupal eye during programmed cell death.
messages: Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory sensilla development.
messages: Nucleus

7227:Dmel CG14360
gene id: 7227:Dmel_CG14360
uniprot id: Q9VFN2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG8346
gene id: 7227:Dmel_CG8346
uniprot id: Q01068
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
messages: The RNA is supplied maternally, and later on, expression is ubiquitous during all stages of embryonic development.
messages: Transcription repression requires formation of a complex with a corepressor protein (Groucho).
messages: Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation.

7227:Dmel CG17544
gene id: 7227:Dmel_CG17544
uniprot id: Q9VIX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

7227:Dmel CG15035
gene id: 7227:Dmel_CG15035
uniprot id: Q9W3R1
names: Similarity
messages: Belongs to the PP2C family.

7227:Dmel CG12344
gene id: 7227:Dmel_CG12344
uniprot id: A0A0B4LF41
uniprot id: Q8SWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

7227:Dmel CG10417
gene id: 7227:Dmel_CG10417
uniprot id: E2QC56
uniprot id: Q7K4Q5
names: Cofactor
names: Similarity
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.

7227:Dmel CG31937
gene id: 7227:Dmel_CG31937
uniprot id: Q9VQ39
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG14540
gene id: 7227:Dmel_CG14540
uniprot id: Q9VBJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Membrane
messages: Probable chloride channel.

7227:Dmel CG11642
gene id: 7227:Dmel_CG11642
uniprot id: Q9W5C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

7227:Dmel CG11639
gene id: 7227:Dmel_CG11639
uniprot id: H0RNC2
uniprot id: Q9W5B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p30), a beta (p20) and a gamma (p14) subunit (By similarity).

7227:Dmel CG11006
gene id: 7227:Dmel_CG11006
uniprot id: M9PCC4
uniprot id: M9PI47
uniprot id: Q8IQH9
uniprot id: Q8IQI0
uniprot id: Q9XZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

7227:Dmel CG17484
gene id: 7227:Dmel_CG17484
uniprot id: Q7PLI0
names: Similarity
messages: Belongs to the beta-catenin family.

7227:Dmel CG6355
gene id: 7227:Dmel_CG6355
uniprot id: O96838
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Flies contain undetectable phosphatidylinositol 3,5-bisphosphate levels, show profound increases in cell and organ size, and die at the pupal stage. Mutant larvae contain highly enlarged multivesicular bodies and late endosomes that are inefficiently acidified. Even though endocytic receptor trafficking is impaired in fab1 mutants, Notch, Wingless, and Dpp signaling is unaffected.
messages: Regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) or PtdIns(3,5)P2) (PubMed:16837550). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)) on the fifth hydroxyl of the myo-inositol ring, to form PtdIns(3,5)P2 (PubMed:16837550). Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.

7227:Dmel CG4336
gene id: 7227:Dmel_CG4336
uniprot id: P50445
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye.
messages: Rough eye phenotype, and/or male sterility and in, some cases, pupal death.
messages: The rux phenotype is suppressed by mutations of genes involved in cell cycle progression such as CycA and string, and enhanced by mutations of intercellular signaling genes, Ras1 and Star.

7227:Dmel CG32401
gene id: 7227:Dmel_CG32401
uniprot id: E5AJF4
uniprot id: P82982
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in olfactory communication for modulating aggression through the sensing of the male-specific pheromone 11-cis-vaccenyl acetate (cVA). Although acute exposure to cVA elicites aggression through Or67d olfactory receptor neurons (ORNs), chronic cVA exposure reduces aggression through Or65a ORNs. Moreover, cVA leads to generalized learning with mated females. It is a major component of the male cuticular hydrocarbon profile, but it is not found on virgin females. During copulation, cVA is transferred to the female in ejaculate along with sperm and peptides that decrease her sexual receptivity.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG5235
gene id: 7227:Dmel_CG5235
uniprot id: M9PFT8
uniprot id: Q9VUY0
names: Cofactor
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Maternally transcribed. During neurogenesis, expression is reactivated in neuroblasts and ganglion mother cells, and disappears as neurons differentiate.
messages: Secreted

7227:Dmel CG7488
gene id: 7227:Dmel_CG7488
uniprot id: Q9VG07
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

7227:Dmel CG8598
gene id: 7227:Dmel_CG8598
uniprot id: H1UUH1
uniprot id: Q9VS50
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Flies display disrupt centromeric sister chromatid cohesion very early in division. This failure of sister chromatid cohesion does not require separase and is correlated with a failure of the cohesin component Scc1 to accumulate in centromeric regions.
messages: Nucleus

7227:Dmel CG42456
gene id: 7227:Dmel_CG42456
uniprot id: E1JIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

7227:Dmel CG17673
gene id: 7227:Dmel_CG17673
uniprot id: E3W289
uniprot id: P05623
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Drosophila sex peptide family.
messages: Main cells of the accessory glands of males (paragonial gland).
messages: Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:3135120, PubMed:19249273, PubMed:20308537, PubMed:19793753, PubMed:15694303, PubMed:24089336). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20458515, PubMed:20308537, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:3135120, PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336).
messages: No expression in females or embryos (PubMed:3135120, PubMed:20458515). Expression levels are highest in male adults with little to no expression until the late pupal stages (PubMed:3135120, PubMed:20458515).
messages: Secreted
messages: Sperm-bound protein is cleaved to release an active C-terminal peptide. Gradual release from stored sperm may function to prolong PMR and enhance male reproductive success.
messages: Viable and fertile (PubMed:19793753). Males are able to transfer sperm but can only induce weak PMR behaviors in females (PubMed:12897240, PubMed:19793753).

7227:Dmel CG41623
gene id: 7227:Dmel_CG41623
uniprot id: A8Y535
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

7227:Dmel CG10335
gene id: 7227:Dmel_CG10335
uniprot id: Q9VTV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

7227:Dmel CG3242
gene id: 7227:Dmel_CG3242
uniprot id: Q9VQS7
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Has two temporally distinct modes of expression during early embryogenesis; expressed in seven stripes at the blastoderm stage. Also expressed in a non-periodic domain at the anterior of the embryo. During gastrulation, the seven primary stripes are supplemented by seven secondary stripes that appear in alternate segments. This results in the labelling of each of the 14 segments in the extended germ band. Expression is relatively weak at the blastoderm stage, gaining in intensity at gastrulation. Expressed in the invaginating stomodeum and proctodeum of the embryonic gut. By stage 13, expressed in the region that will form the proventriculus and in a wide ring at the most posterior portion of the midgut. Expression continues in the gut through the remainder of embryogenesis. Expressed in the proximal Malpighian tubules, brain and pharyngeal muscles during late embryogenesis. Expressed weakly in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4.
messages: Nucleus
messages: Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity). May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.

7227:Dmel CG1966
gene id: 7227:Dmel_CG1966
uniprot id: Q9V9T4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG11140
gene id: 7227:Dmel_CG11140
uniprot id: A0A0B4KEE1
uniprot id: A0A0B4KEL0
uniprot id: A0A0B4KF99
uniprot id: A0A0C4DHC8
uniprot id: A0A0C4FEI5
uniprot id: A1Z6Z3
uniprot id: A1Z6Z4
uniprot id: A4UZ69
uniprot id: Q7JR61
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7227:Dmel CG17064
gene id: 7227:Dmel_CG17064
uniprot id: E1JH57
uniprot id: Q7K3L1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SAPAP family.
messages: Cell cycle regulator.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the central nervous system and at different stages of gametogenesis. In embryos, it is expressed in central nervous system and brain. In testis, it is strongly expressed in pre-meiotic germ cells, but is not found in somatic or post-meiotic cells.
messages: Predominantly expressed in embryos and in the adult germline (at protein level). Only present in mitotic cells; at the anaphase and telophase, its begins to degrade.
messages: nucleoplasm
messages: spindle

7227:Dmel CG34395
gene id: 7227:Dmel_CG34395
uniprot id: A8DYZ8
uniprot id: P31368
uniprot id: X2JDY7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family.
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.
messages: Expressed both maternally and zygotically.
messages: Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.
messages: Nucleus

7227:Dmel CG32103
gene id: 7227:Dmel_CG32103
uniprot id: M9PF04
uniprot id: Q0E8F2
uniprot id: Q9VTX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG8090
gene id: 7227:Dmel_CG8090
uniprot id: Q3ZAN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

7227:Dmel CG7439
gene id: 7227:Dmel_CG7439
uniprot id: Q9VUQ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with cricket paralysis virus protein 1A; this interaction may block the RISC activity.
messages: Belongs to the argonaute family. Ago subfamily.
messages: Cytoplasmic ribonucleoprotein granule
messages: Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing (PubMed:11498593, PubMed:12368261, PubMed:14508492, PubMed:32504809). RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger (PubMed:11498593, PubMed:12368261, PubMed:14508492).
messages: Interacts with Fmr1, Dcr-1 and vig to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are RpL5, RpL11 and Rm62 (PubMed:11498593, PubMed:14508492, PubMed:12368261). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492).
messages: PAZ domain provides a major contribution for nucleic acid recognition. PAZ binds oligonucleotides of different lengths and has a strong preference for single-stranded nucleic acids (ssRNA or SSDNA) or RNA duplexes with single-stranded 3' overhangs. Can bind the characteristic two-base 3' overhangs of siRNAs, indicating that it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.

7227:Dmel CG16988
gene id: 7227:Dmel_CG16988
uniprot id: Q9NHX0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RING-box family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).
messages: Cytoplasm
messages: Highly expressed in early embryos, and in pupae. Widely expressed in adult males, while it is weakly expressed in adult females.
messages: It is uncertain whether Met-1 or Met-16 is the initiator.
messages: Nucleus
messages: Part of a SCF complex consisting of Skpa (SKP1), Cul1, Roc1B and a F-box protein.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity).

7227:Dmel CG46275
gene id: 7227:Dmel_CG46275
uniprot id: Q8IRZ3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7227:Dmel CG11103
gene id: 7227:Dmel_CG11103
uniprot id: Q9VY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

7227:Dmel CG4233
gene id: 7227:Dmel_CG4233
uniprot id: Q8IPY3
uniprot id: Q9VQ61
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

7227:Dmel CG9206
gene id: 7227:Dmel_CG9206
uniprot id: P13496
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin 150 kDa subunit family.
messages: Cytoplasm
messages: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein.
messages: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
messages: cytoskeleton

7227:Dmel CG3224
gene id: 7227:Dmel_CG3224
uniprot id: Q9W3Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.
messages: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.
messages: Nucleus

7227:Dmel CG15019
gene id: 7227:Dmel_CG15019
uniprot id: Q9VZC8
names: Similarity
messages: Belongs to the learning-associated protein family.

7227:Dmel CG8567
gene id: 7227:Dmel_CG8567
uniprot id: Q24180
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.
messages: Ubiquitous throughout embryogenesis. Highly expressed in stage 3 embryo indicating that it is maternally provided. After stage 15, it is more prominent in the central nervous system.

7227:Dmel CG13367
gene id: 7227:Dmel_CG13367
uniprot id: Q9W5E2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10757
gene id: 7227:Dmel_CG10757
uniprot id: Q9VIN9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.

7227:Dmel CG8764
gene id: 7227:Dmel_CG8764
uniprot id: A0A1B2AJQ1
uniprot id: Q9XY35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG32281
gene id: 7227:Dmel_CG32281
uniprot id: Q8IRE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

7227:Dmel CG7756
gene id: 7227:Dmel_CG7756
uniprot id: P11146
names: Developmental Stage
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock cognate proteins are expressed constitutively during normal development.

7227:Dmel CG32626
gene id: 7227:Dmel_CG32626
uniprot id: D0IQK3
uniprot id: M9MS55
uniprot id: M9NDW2
uniprot id: Q76NQ9
uniprot id: Q76NR0
uniprot id: Q961Q7
uniprot id: Q9VY76
uniprot id: X2JEY5
uniprot id: X2JFA0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

7227:Dmel CG46276
gene id: 7227:Dmel_CG46276
uniprot id: Q8IRZ3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7227:Dmel CG15828
gene id: 7227:Dmel_CG15828
uniprot id: Q7KTG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8213
gene id: 7227:Dmel_CG8213
uniprot id: B7YZU2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Cell membrane
messages: Detected in embryo at stage 13 in the posterior spiracles and foregut primordium. By stage 15, expressed specifically in epithelia secreting cuticle, including the trachea, foregut, hindgut and epidermis.
messages: Embryonic lethal. RNAi-mediated knockdown in tracheal terminal cells results in cystic dilations and discontinuities of the apical membrane; terminal cells are severely pruned with terminal branches largely devoid of lumenal membrane, except for isolated inclusions.
messages: Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins.

7227:Dmel CG18335
gene id: 7227:Dmel_CG18335
uniprot id: Q7JRP4
names: Similarity
messages: Belongs to the UPF0605 family.

7227:Dmel CG6517
gene id: 7227:Dmel_CG6517
uniprot id: P07184
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chorion protein S15/S18 family.
messages: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
messages: Secreted

7227:Dmel CG4643
gene id: 7227:Dmel_CG4643
uniprot id: Q9V6L9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FBXO45/Fsn family.
messages: Component of an E3 ubiquitin ligase complex composed of hiw and Fsn (PubMed:17697379, PubMed:21874015). Interacts with Rae1, probably as part of the hiw-Fsn complex (PubMed:21874015). Interacts (via B30.2/SPRY domain) with vas (PubMed:20123973). Interacts with Cul1 (PubMed:20123973).
messages: Cytoplasm
messages: Dramatic overgrowth of synaptic termini, with a large increase in the number of synaptic boutons and branches. Also impaired synaptic transmission.
messages: Expressed in nurse cells and oocytes (at protein level) (PubMed:20123973). Expressed in the brain (PubMed:21874015). Expressed in the neuromuscular junction (NMJ) (PubMed:17697379).
messages: Expressed in oocytes (at protein level).
messages: Nucleus
messages: Perikaryon
messages: Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation.
messages: Synapse
messages: axon

7227:Dmel CG17026
gene id: 7227:Dmel_CG17026
uniprot id: Q9VUW1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG16836
gene id: 7227:Dmel_CG16836
uniprot id: A1ZB62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bomanin family.
messages: Secreted
messages: Secreted immune-induced peptide induced by Toll signaling (PubMed:25915418, PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489).

7227:Dmel CG3829
gene id: 7227:Dmel_CG3829
uniprot id: Q961K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG33774
gene id: 7227:Dmel_CG33774
uniprot id: A0A1B2AKM1
uniprot id: A1Z7U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST4 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7227:Dmel CG10578
gene id: 7227:Dmel_CG10578
uniprot id: Q24133
names: Induction
names: Subcellular Location Annotation
messages: By heat shock.
messages: Cytoplasm

7227:Dmel CG11781
gene id: 7227:Dmel_CG11781
uniprot id: Q9VBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG1102
gene id: 7227:Dmel_CG1102
uniprot id: A0A126GUP6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: RNAi-mediated knockdown is semi-pupal lethal, with 50% of pupae dying at the late pupal stage or during eclosion (PubMed:16861233). Adults display impaired melanization at the site of septic infection (septic injury) using either Gram-negative (E.coli) or Gram-positive bacteria (M.luteus) (PubMed:16861233). No significant increase in PPO1 activity after septic injury using fungi (B.bassiana) and bacteria (PubMed:16861233). Survival and induction of antimicrobial peptides (Dpt and Drs) is not affected after bacterial or fungal infection (PubMed:16861233). Aseptic wounding has no effect on survival (PubMed:22227521).
messages: Serine protease which plays an essential role in the melanization immune response by acting downstream of sp7 to activate prophenoloxidase (PPO1) (PubMed:16861233). May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea (PubMed:18854145, PubMed:16861233). Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway (PubMed:16861233).
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG2397
gene id: 7227:Dmel_CG2397
uniprot id: Q9V4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG32418
gene id: 7227:Dmel_CG32418
uniprot id: Q8SWS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

7227:Dmel CG11421
gene id: 7227:Dmel_CG11421
uniprot id: P54193
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PBP/GOBP family.
messages: Expressed in adult but not in larval olfactory organs.
messages: In the ventrolateral region of the antenna, expressed in two distinct types of olfactory hairs: in most sensilla trichodea and in a subset of the small sensilla basiconica (at protein level).
messages: Secreted

7227:Dmel CG5793
gene id: 7227:Dmel_CG5793
uniprot id: Q9VDE2
names: Similarity
messages: Belongs to the FAH family.

7227:Dmel CG8303
gene id: 7227:Dmel_CG8303
uniprot id: A0A0B4LFD0
uniprot id: A1ZAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Membrane

7227:Dmel CG17876
gene id: 7227:Dmel_CG17876
uniprot id: P81641
uniprot id: Q5BIJ9
names: Cofactor
names: Polymorphism
names: Similarity
names: Subunit
messages: At least 6 electrophoretic isozymes are known: Amy1, Amy2, Amy3, Amy4, Amy5 and Amy6. Strains KO123 expresses Amy1; J87 expresses Amy3; 1420#1, L16 and TN256 express Amy6.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 Cl(-) ion per subunit.
messages: Monomer.

7227:Dmel CG2658
gene id: 7227:Dmel_CG2658
uniprot id: Q9W4W8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

7227:Dmel CG31152
gene id: 7227:Dmel_CG31152
uniprot id: A0A0B4KGR5
uniprot id: Q8T045
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 90 family.
messages: Endoplasmic reticulum lumen
messages: Expressed both maternally and zygotically.
messages: Flies exhibit a temperature-dependent loss of Notch signaling, resulting in bristle loss (PubMed:18243100). Defects in muscle development (PubMed:27807076).
messages: Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats (PubMed:27428513). Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.

7227:Dmel CG14544
gene id: 7227:Dmel_CG14544
uniprot id: Q9VBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

7227:Dmel CG5815
gene id: 7227:Dmel_CG5815
uniprot id: Q8IMP6
names: Similarity
messages: Belongs to the SPT2 family.

7227:Dmel CG15332
gene id: 7227:Dmel_CG15332
uniprot id: Q9W3M2
names: Similarity
messages: Belongs to the DM7 family.

7227:Dmel CG2893
gene id: 7227:Dmel_CG2893
uniprot id: A0A021WZA4
uniprot id: Q5LJX7
uniprot id: Q5LJX8
uniprot id: Q7PLW1
uniprot id: Q8SXS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7227:Dmel CG10804
gene id: 7227:Dmel_CG10804
uniprot id: B7Z122
uniprot id: Q8IRU1
uniprot id: Q9W4S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG1147
gene id: 7227:Dmel_CG1147
uniprot id: A0A0B4K601
uniprot id: A0A0B4K6A5
uniprot id: A0A0B4K6K3
uniprot id: Q9VNM1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Expressed in midgut, brain lobes and ventral nerve cord of larvae. In adults, expressed in a pair of dorsolateral neurons in the protocerebrum, and the central complex and a small number of neurons in the subesophageal ganglion (at protein level). Expressed in a subset of sugar-responsive PAIN neurons in the thoracic body but is absent from other peripheral PAIN neurons.
messages: Increased NPF or NPFR activity dominantly suppresses PAIN-mediated food aversion in postfeeding larvae. Deficiency in NPF/NPFR signaling causes decreased alcohol sensitivity and overexpression causes a hypersensitive response to alcohol sedation. Controlled functional disruption of NPF or NPFR neurons rapidly triggers acute resistance to ethanol sedation.
messages: Membrane
messages: Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference.

7227:Dmel CG10738
gene id: 7227:Dmel_CG10738
uniprot id: C7LAF5
uniprot id: M9NFA6
uniprot id: Q8IQK2
uniprot id: Q9VU79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

7227:Dmel CG32423
gene id: 7227:Dmel_CG32423
uniprot id: Q8MSV2
names: Function
names: Miscellaneous
messages: Has a role in the perception of gravity.
messages: Named after Alan Bartlett Shepard, Jr. who was the second person and the first American in space and the fifth person to walk on the moon.

7227:Dmel CG16869
gene id: 7227:Dmel_CG16869
uniprot id: Q9VJV2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG1220
gene id: 7227:Dmel_CG1220
uniprot id: O97042
uniprot id: Q7KYD6
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG31373
gene id: 7227:Dmel_CG31373
uniprot id: Q8INL3
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

7227:Dmel CG10158
gene id: 7227:Dmel_CG10158
uniprot id: M9PEZ2
uniprot id: Q9VM65
names: Similarity
messages: Belongs to the SIKE family.

7227:Dmel CG7014
gene id: 7227:Dmel_CG7014
uniprot id: A0A0B4K683
uniprot id: Q9VFE4
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

7227:Dmel CG4637
gene id: 7227:Dmel_CG4637
uniprot id: Q02936
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cholesterylation is required for N-product targeting to lipid rafts and multimerization.
messages: Cytoplasm
messages: Expressed in embryos, larvae and pupae at high levels with maximum expression in 6-12 hours embryos and 0-24 hours pupae (PubMed:8166882, PubMed:1394430, PubMed:1280560, PubMed:1340474). Low levels of expression are seen in adults (PubMed:8166882, PubMed:1394430).
messages: In embryos, expression starts at stage 5 as a few stripes at the anterior and posterior ends, this expands to 17 stripes during stages 8-11 (PubMed:8166882, PubMed:1280560, PubMed:1340474). Expression is also seen in CNS and some PNS cells until stage 13-14, and in foregut, hindgut and salivary glands (PubMed:1340474). In larvae, expression is seen in the posterior compartment of the wing, leg and antennal imaginal disks (PubMed:1394430, PubMed:1340474). In adults, high level of expression in specific regions of the proventriculus and hindgut, with slightly lower levels of expression in the posterior midgut (PubMed:25639794). Relatively low levels of expression in the anterior midgut region (PubMed:25639794).
messages: Interacts with shf.
messages: N-palmitoylation by Rasp of the hedgehog N-product, within the secretory pathway, is required for the embryonic and larval patterning activities of the hedgehog signal.
messages: Nucleus
messages: RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora. Abolishes Cad99C-dependent formation of endosomes and DUOX-dependent up-regulation of reactive oxygen species (ROS) in the intestines of adults fed bacteria-derived uracil.
messages: Strongly up-regulated in the anterior midgut and the posterior midgut in response to bacterial uracil.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (PubMed:7885476). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Once cleaved, the C-product has no signaling activity and diffuses from the cell (PubMed:12586063).
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (PubMed:7885476). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development (PubMed:25639794, PubMed:27195754, PubMed:8166882, PubMed:1394430, PubMed:1340474, PubMed:11319862). Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos (PubMed:27195754, PubMed:25639794, PubMed:8166882, PubMed:1394430, PubMed:1340474, PubMed:11319862).

7227:Dmel CG10794
gene id: 7227:Dmel_CG10794
uniprot id: A1ZBF6
names: Similarity
messages: Belongs to the attacin/sarcotoxin-2 family.

7227:Dmel CG30147
gene id: 7227:Dmel_CG30147
uniprot id: Q0E908
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transglutaminase-like superfamily.
messages: Cleavage furrow
messages: Interacts with pnut.
messages: Localizes to the neuropil of the embryonic central nervous system (at protein level). Also detected in third instar larval brain (at protein level).
messages: May act as a modulator of septin function during cytokinesis in the developing nervous system.
messages: Mutants are viable with a 98.4% hatch rate which is close to the wild-type hatch rate. No apparent defects in the central nervous system.
messages: Very low levels detected in 0-6 hour embryos with expression up-regulated after 12 hours of embryogenesis and persisting into adult stages (at protein level).
messages: cell cortex

7227:Dmel CG18767
gene id: 7227:Dmel_CG18767
uniprot id: Q9I7Q9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

7227:Dmel CG13978
gene id: 7227:Dmel_CG13978
uniprot id: Q9VB32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG43782
gene id: 7227:Dmel_CG43782
uniprot id: Q9VSR3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broadly expressed throughout the nervous system of embryo, larva and adult including the ventral nerve cord and brain (at protein level) (PubMed:23083740, PubMed:32165583). In early embryos, deposited maternally and distributed uniformly throughout the embryo until the extended germband stage (PubMed:21900268). By mid-embryogenesis, highest levels are found in the central and peripheral nervous systems with lower expression also detected in the ectoderm and mesoderm (PubMed:21900268). In adults, high levels are present in the head and body of both sexes with higher expression in testis than ovary (PubMed:21900268). In the ovary, expressed in both germ and follicle cells (PubMed:21900268). In adult head, predominantly neuronal with broad expression throughout the brain and ventral ganglia including the mushroom body (PubMed:17965711, PubMed:21900268).
messages: Cytoplasm
messages: Expressed in 0- to 2-hour-old embryos (at protein level) (PubMed:32165583). Expressed in the larval motor neuron cells in the brain (at protein level) (PubMed:29105522). Expressed throughout development in both the soma and germline. Widely expressed in early embryos with levels dropping during mid-embryogenesis and increasing again in late embryogenesis. Expression is relatively low during larval stages with lowest levels in the first and second instars and an increase during the third instar. Levels increase substantially during the pupal stage and remain relatively high in the adult. In the ovary, little expression in the germarium or previtellogenic stage chambers with levels increasing midway through oogenesis and remaining high until stage 10 (PubMed:21900268). In the testis, there is substantial up-regulation after mitosis is finished and the interconnected spermatocytes begin to grow (PubMed:23209437). Expression peaks as the mature spermatocytes go through meiosis and high levels are found in 32- and 64-cell spermatid cysts with expression persisting after the spermatids in the 64-cell cysts start differentiation and disappearing once elongation and nuclear condensation are completed (PubMed:23209437).
messages: Fails to form stable long-term memory during male courtship suppression, in which a male fly, upon repeated exposure to an unreceptive female, suppresses its courting behavior for days (PubMed:28525754). In neurons, increases levels of the tumor suppressor brat (PubMed:29105522).
messages: In the adult brain the mRNA is expressed as an unspliced non-protein coding mRNA; inclusion of isoform A-specific exon in the mature transcript is important for long-term memory; mRNA levels depends on behavioral stimulus and splicing depends on the activity of the splicing regulator ps.
messages: Lowering pH destabilizes the protein filaments.
messages: Monomer (PubMed:22284910, PubMed:23083740, PubMed:32165583). Upon neuronal stimulation, forms stable amyloid-like oligomers composed of isoform A and isoform B which are required for formation of persistent long-term memory (PubMed:22284910, PubMed:23083740, PubMed:32165583). Isoform A is critical for oligomer formation (PubMed:22284910, PubMed:23083740). Phe-5 of isoform A is required for amyloid-like oligomerization (PubMed:22284910, PubMed:26812143). Rapidly forms amyloids and toxic intermediates are extremely transient (PubMed:26812143). Unlike in the adult nervous system, remains monomeric in the early embryo (PubMed:32165583). Interacts with the translational regulator bol (PubMed:23209437). Interacts with Tob; the interaction is enhanced by neuronal stimulation, stabilizes isoform A and induces oligomerization (PubMed:24523662).
messages: Perikaryon
messages: Phosphorylation regulates interaction with Tob and oligomerization. Protein phosphatase 2A keeps both Orb2 and Tob in an unphosphorylated form. Following synaptic activation, unphosphorylated Orb2 is bound and stabilized by unphosphorylated Tob. Tob recruits activated LimK which phosphorylates both Orb2 and Tob and enhances Orb2 oligomerization.
messages: RNA-binding protein involved in translational regulation and required for long-term memory (PubMed:28525754, PubMed:29105522). Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367, PubMed:32165583). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074, PubMed:32165583). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074, PubMed:32165583). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Plays a role in synapse formation and morphology at neuromuscular junctions by modulating the translation of the tumor suppressor brat (PubMed:29105522). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).
messages: Required for initial memory acquisition (PubMed:26095367, PubMed:28525754). Following subsequent late dopaminergic pathway activation, recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367).
messages: Substantially reduced viability with surviving males being completely sterile due to a failure of spermatocytes to complete meiosis with arrest happening at the G2-M transition (PubMed:23209437). Defective spermatid cyst polarization (PubMed:24830287). RNAi-mediated knockdown in motor neurons decreases number of synapses and accumulation of the tumor suppressor brat at neuromuscular junctions (NMJ) (PubMed:29105522). Simultaneous knockdown of the tumor suppressor brat restablishes the number of synapses at NMJ (PubMed:29105522).
messages: Synapse
messages: The N-terminal Gln/His-rich domain is both dispensable and insufficient for long-term memory and for formation of amyloid-like oligomers with isoform A.
messages: The N-terminal Gln/His-rich domain is necessary and sufficient for long-term memory and is required for formation of amyloid-like oligomers with isoform B (PubMed:17965711, PubMed:23083740). Binds transition metals (PubMed:28763009). Might bind lipid membranes (PubMed:28700922).
messages: The RNA-binding region is essential for long-term memory.
messages: The RNA-binding region is not essential for long-term memory.
messages: axon
messages: dendrite
messages: perinuclear region

7227:Dmel CG32069
gene id: 7227:Dmel_CG32069
uniprot id: Q9VTE1
names: Similarity
messages: Belongs to the YOS1 family.

7227:Dmel CG8249
gene id: 7227:Dmel_CG8249
uniprot id: A1ZA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG13762
gene id: 7227:Dmel_CG13762
uniprot id: Q9W4X5
uniprot id: X2JI61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

7227:Dmel CG6282
gene id: 7227:Dmel_CG6282
uniprot id: M9PET5
uniprot id: Q9VSM5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8821
gene id: 7227:Dmel_CG8821
uniprot id: A1Z913
uniprot id: Q7K380
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG34092
gene id: 7227:Dmel_CG34092
uniprot id: P18929
uniprot id: Q9MGN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG18287
gene id: 7227:Dmel_CG18287
uniprot id: Q9VAJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Expressed in the tracheal system. Expressed in the taste-sensing terminal organ of the larval head. In adults, expressed in hairs on the tibia, femur and wing margin, but not in hairs on the tarsi of the leg.
messages: Membrane
messages: Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport.

7227:Dmel CG11898
gene id: 7227:Dmel_CG11898
uniprot id: Q9VAN4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7169
gene id: 7227:Dmel_CG7169
uniprot id: Q9VP10
names: Similarity
messages: Belongs to the peptidase S8 family.

7227:Dmel CG7960
gene id: 7227:Dmel_CG7960
uniprot id: Q24039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus
messages: Regulates the DNA-binding properties of Runt.

7227:Dmel CG9104
gene id: 7227:Dmel_CG9104
uniprot id: Q9VXA0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823, PubMed:25512509). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823, PubMed:25512509). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823). In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:27672113, PubMed:25512509). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509).
messages: Belongs to the NPR2 family.
messages: Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823). Interacts with Nprl3 (PubMed:24786828).
messages: Cytoplasm
messages: Lysosome
messages: Pupal homozygous semi-lethal (PubMed:27672113). Under nutrient-replete conditions, larvae display a significant increase in TORC1 activity and adult escapers display a small, but significant increase in body weight and a reduction in climbing (PubMed:27672113). Newly hatched males display decreased tolerance to both complete starvation and amino acid starvation, likely due to decreased triacylglyceride (TAG) storage and the inability to down-regulate TORC1 activity and activate catabolic metabolism and autophagy (PubMed:27672113). Conditional RNAi-mediated knockdown in the female germline results in a small decrease in the rate of egg production when females are provided with a protein source of wet yeast (PubMed:24786828). Females starved of amino acids for a brief period have increased numbers of degenerating young eggs and show permanent loss of fertility (PubMed:24786828). Mid-stage egg chambers are unaffected (PubMed:24786828). Double RNAi-mediated knockdown with another GATOR1 complex member Iml1 in the female germline, increases the penetrance of ovarian cysts displaying delayed mitotic exit and producing 32-cell cysts (PubMed:25512509).

7227:Dmel CG13310
gene id: 7227:Dmel_CG13310
uniprot id: Q9VSQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7200
gene id: 7227:Dmel_CG7200
uniprot id: Q9VJ97
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG1469
gene id: 7227:Dmel_CG1469
uniprot id: A0A0B4KHF0
uniprot id: Q9VA83
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7227:Dmel CG17632
gene id: 7227:Dmel_CG17632
uniprot id: A0A0B4LHB3
uniprot id: P12428
names: Disruption Phenotype
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters and metabolic intermediates (PubMed:117796, PubMed:8144619, PubMed:10407069, PubMed:18931318, PubMed:33820991). In the eye and probably in association with w/white, required for the transport of the eye red pigment precursor, guanine, into pigment cell granules (PubMed:8144619, PubMed:117796). In Malpighian tubules, involved in guanine uptake (PubMed:117796). Probably in association with w/white, involved in aging-induced intestinal stem cell proliferation in the midgut by regulating tetrahydrofolate transport (PubMed:33820991).
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Eyes are brown due to a defect in red pigment production (PubMed:10407069). In Malpighian tubules, guanine uptake is impaired (PubMed:117796). Reduces the levels of several metabolites, including kynurenine, kynurenic acid, 3-hydroxykynurenine, guanosine, xanthine, urate, riboflavin, and tetrahydrofolate, and increases the levels of guanine (PubMed:33820991). In the head, levels of neurotransmitters histamine, dopamine and serotonin are reduced; specifically, histamine is reduced in the retina (PubMed:18931318). Severe loss of white protein in the retina lamina and photoreceptors (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, number of synaptic vesicles is reduced (PubMed:18931318). Inhibits aging-induced intestinal stem cell proliferation (PubMed:33820991).
messages: May form a heterodimer with w/white.
messages: Membrane
messages: Probable cloning artifact.
messages: Up-regulated during aging in intestinal stem cells.

7227:Dmel CG30330
gene id: 7227:Dmel_CG30330
uniprot id: P58985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons. In larvae, is expressed in neurons of the terminal external chemosensory organ as well as in the dorsal pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG6054
gene id: 7227:Dmel_CG6054
uniprot id: Q9VG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG12532
gene id: 7227:Dmel_CG12532
uniprot id: Q24253
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7227:Dmel CG9935
gene id: 7227:Dmel_CG9935
uniprot id: A0A023GQ97
uniprot id: Q0KIF2
uniprot id: Q9V4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG9484
gene id: 7227:Dmel_CG9484
uniprot id: P51592
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: A cysteine residue is required for ubiquitin-thioester formation.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrate (PubMed:32339205). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk (PubMed:12421709, PubMed:7958417). Catalyzes 'Lys-63'-linked polyubiquitination of akirin, thereby activating the immune deficiency pathway (Imd) (PubMed:32339205).
messages: Ectopic expression of hh and dpp, resulting in non autonomous overgrowth of the disc and premature photoreceptor differentiation that propagates into the surrounding tissue.
messages: Expressed at all stages of development, with high levels at the embryonic and pupal stages (at protein level).
messages: Nucleus

7227:Dmel CG43665
gene id: 7227:Dmel_CG43665
uniprot id: Q24208
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimeric G-protein composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.
messages: Isoform B expressed maternally and zygotically. Isoform B expressed throughout development, in larvae, in pupae and in adult flies.

7227:Dmel CG7669
gene id: 7227:Dmel_CG7669
uniprot id: Q9VE87
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CFAP97 family.
messages: Cytoplasm
messages: Detected in ciliated sensory neurons at all stages of development, and in adult testis.
messages: In the testis, expressed in spermatocytes and elongating spermatids.
messages: Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs.
messages: Perikaryon
messages: Viable with no gross coordination or gravitaxis defects. Males are sterile with complete absence of mature spermatozoa, while female fertility is unaffected. In developing spermatids, axonemes fail to elongate normally and sperm individualization is disrupted. Tubulin glycylation of spermatid axonemes is abnormal. Hearing is moderately impaired.
messages: cilium

7227:Dmel CG3481
gene id: 7227:Dmel_CG3481
uniprot id: P00334
names: Activity Regulation
names: Polymorphism
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Homodimer.
messages: Inhibited by 2,2,2-trifluoroethanol and pyrazole.
messages: Virtually all natural populations of this species are polymorphic for 2 electrophoretically distinguishable alleles, Adh-S and Adh-F (PubMed:6789320, PubMed:6410283, PubMed:1673107, PubMed:1683848, Ref.12, PubMed:12537569, Ref.18, PubMed:6821373, PubMed:6780981). The sequence of the Adh-S allele is shown (PubMed:6789320, PubMed:6410283, PubMed:1673107, Ref.12, PubMed:12537569, Ref.18, PubMed:6821373). Other naturally occurring alleles include Adh-JA-F, Adh-AF-S, Adh-F-CHD, Adh-71K, Adh-UF and Adh-F' (PubMed:3021568, PubMed:3137352, PubMed:2124644, PubMed:6789328, PubMed:115502, PubMed:6821373). Artificially induced mutations include Adh-NB, Adh-NLA248, Adh-N4 and Adh-N11 (PubMed:6818527, PubMed:3928896, PubMed:3108863, PubMed:6821373, PubMed:2419573).

7227:Dmel CG9537
gene id: 7227:Dmel_CG9537
uniprot id: Q9VMD0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in all developmental stages (PubMed:17933869). Higher level of expression detected at the end of the third larval stage, in adult females and in early embryos containing maternally deposited transcripts (PubMed:17933869). At later stages of development, specific expression can be detected in tissues containing mitotic cells such as in the brain hemispheres and imaginal disks (PubMed:17933869).
messages: Interacts with p53 (via C-terminus) (PubMed:17933869). Interacts (via C-terminus) with His3.3A and His3.3B (PubMed:28320872). Interacts with asf1 (PubMed:28320872).
messages: Nucleus
messages: Reduces longevity and female fertility, but increases resistance to oxidative stress and UV irradiation-induced pupal lethality (PubMed:23593018). Double knockouts for DJ-1beta and Daxx restore normal number of dopaminergic neurons, locomotor activity and sensitivity to oxidative stress and UV-induced damage (PubMed:23593018). RNAi-mediated knockdown results in increased resistance to oxidative stress (PubMed:23593018).
messages: Transcription regulator (PubMed:23593018, PubMed:17933869). Acts as a histone chaperone that facilitates deposition of histone H3.3 (PubMed:28320872). Has a role in chromatin remodeling together with asf1 and XNP (PubMed:28320872). Has role in the transcriptional apoptotic response to oxidative and UV stress (PubMed:17933869, PubMed:23593018).
messages: Ubiquitously expressed with higher levels in the head (at protein level) (PubMed:23593018). Expressed in the germ line, with prominent expression in primary spermatocytes and meiotic spermatocytes (at protein level) (PubMed:28320872). In ovaries, expressed in nurse cells and in the germinal vesicle of the ovarian follicle at stage 10 (at protein level) (PubMed:28320872).
messages: cytosol

7227:Dmel CG8340
gene id: 7227:Dmel_CG8340
uniprot id: P32234
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Deformed (Dfd) is required to activate 128up in maxillary segment cells.
messages: Expressed in embryos and adults.
messages: Expressed in posterior-lateral epidermis of the maxillary lobe.

7227:Dmel CG8627
gene id: 7227:Dmel_CG8627
uniprot id: P42281
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters (By similarity). May be involved in energy metabolism in a manner that depends on the substrate used for energy production. Dbi and its metabolites are involved in the regulation of multiple biological processes.
messages: Expressed from the larval stage onwards throughout the adult stage.
messages: Expressed in larval and pupal brains. In adults, expressed in cardia, part of the Malpighian tubules, fat body, and gametes of both sexes.

7227:Dmel CG33818
gene id: 7227:Dmel_CG33818
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG9636
gene id: 7227:Dmel_CG9636
uniprot id: Q7KSV7
uniprot id: Q95T08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG33832
gene id: 7227:Dmel_CG33832
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG9582
gene id: 7227:Dmel_CG9582
uniprot id: Q9VLF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG5303
gene id: 7227:Dmel_CG5303
uniprot id: A0A0B4LG47
uniprot id: Q24141
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shugoshin family.
messages: Expressed both maternally and zygotically. Present throughout embryogenesis and larval stages.
messages: Homodimer. Interacts with Incenp.
messages: Phosphorylation by polo-like kinase (PLK) on Thr-331 antagonizes cohesive function. Phosphorylation on Thr-331 at the metaphase anaphase transition leads to its dissociation from centromeres. In contrast, phosphorylation by aurB/ial on either Ser-124, Ser-125 or Ser-126 is required for association with centromeres.
messages: Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females.
messages: centromere

7227:Dmel CG7580
gene id: 7227:Dmel_CG7580
uniprot id: Q9VVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG9901
gene id: 7227:Dmel_CG9901
uniprot id: P45888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP2 subfamily.
messages: Component of the Arp2/3 complex.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
messages: cytoskeleton

7227:Dmel CG45071
gene id: 7227:Dmel_CG45071
uniprot id: Q9VUK9
uniprot id: X2J927
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG1342
gene id: 7227:Dmel_CG1342
uniprot id: Q9VA48
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG14079
gene id: 7227:Dmel_CG14079
uniprot id: Q9VVW9
names: Similarity
messages: Belongs to the SPATA6 family.

7227:Dmel CG6352
gene id: 7227:Dmel_CG6352
uniprot id: Q9VX20
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG1640
gene id: 7227:Dmel_CG1640
uniprot id: Q7KV27
uniprot id: Q9VYD9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

7227:Dmel CG42234
gene id: 7227:Dmel_CG42234
uniprot id: Q9W064
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13787
gene id: 7227:Dmel_CG13787
uniprot id: Q9VM09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
messages: Cell membrane
messages: In addition to expression in a large number of taste neurons, Gr28a is also expressed in a few nonchemosensory neurons, including the campaniform sensilla of the wing, leg stretch receptors, and multiple dendritic (MD) neurons in the abdomen. In larvea, is expressed in neurons of the terminal external chemosensory organ, the dorsal external chemosensory organ, as well as in the ventral and posterior pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.

7227:Dmel CG4904
gene id: 7227:Dmel_CG4904
uniprot id: I0DHK3
uniprot id: P12881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG4163
gene id: 7227:Dmel_CG4163
uniprot id: Q9V399
uniprot id: X2JA13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG3048
gene id: 7227:Dmel_CG3048
uniprot id: A8DYU9
uniprot id: Q9XYR0
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG3994
gene id: 7227:Dmel_CG3994
uniprot id: Q8IP48
uniprot id: Q9V471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7227:Dmel CG9536
gene id: 7227:Dmel_CG9536
uniprot id: Q9VMD2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9326
gene id: 7227:Dmel_CG9326
uniprot id: M9PDB2
uniprot id: Q7KT16
uniprot id: Q9VIJ4
names: Similarity
messages: Belongs to the MAGUK family.

7227:Dmel CG32211
gene id: 7227:Dmel_CG32211
uniprot id: M9PG32
uniprot id: P49847
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF6 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). E(y)1 and Taf6 exist as a heterotetramer. Interacts with Taf1.
messages: Nucleus
messages: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

7227:Dmel CG4920
gene id: 7227:Dmel_CG4920
uniprot id: P13582
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activation peptide and active catalytic domain are associated by a disulfide bond. Processed easter is present in extremely low amounts in the early embryo as it is rapidly converted into a high molecular mass complex, which may contain a protease inhibitor. Zymogen activation is also controlled by a negative feedback loop from Dorsal.
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9477324, PubMed:2107028, PubMed:12493753). Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324). Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324).
messages: Expressed both maternally and zygotically.
messages: Secreted
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG12374
gene id: 7227:Dmel_CG12374
uniprot id: Q7JYV3
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG31359
gene id: 7227:Dmel_CG31359
uniprot id: Q8INI8
uniprot id: Q9BIR7
uniprot id: Q9BIS2
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
messages: Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

7227:Dmel CG14696
gene id: 7227:Dmel_CG14696
uniprot id: Q9VGU7
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG1064
gene id: 7227:Dmel_CG1064
uniprot id: Q24090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

7227:Dmel CG3351
gene id: 7227:Dmel_CG3351
uniprot id: Q9VFJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG6384
gene id: 7227:Dmel_CG6384
uniprot id: Q24478
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.
messages: Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:15574329). Interacts with Cp60 and microtubules (PubMed:8590797, PubMed:9700165, PubMed:8491775, PubMed:8522588, PubMed:14996941). Interacts with inv (PubMed:25561495). Interacts with Nup98 (PubMed:28366641).
messages: Expressed in spermatids but not in mature spermatozoa. Localizes within the spermatids to a sheath of microtubules around the nucleus and to microtubules within the tail.
messages: Localizes to the centrosome throughout the nuclear division cycle in early syncytial embryos. Localization to the interphase nucleus is seen from nuclear cycle 9 onwards.
messages: Nucleus
messages: cytoskeleton

7227:Dmel CG42840
gene id: 7227:Dmel_CG42840
uniprot id: B5RJR1
uniprot id: M9MRE4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7227:Dmel CG8269
gene id: 7227:Dmel_CG8269
uniprot id: Q7K2D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 2 family.
messages: Membrane
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity).
messages: Subunit of dynactin, a multiprotein complex associated with dynein.
messages: cytoskeleton

7227:Dmel CG12717
gene id: 7227:Dmel_CG12717
uniprot id: Q9VYJ5
names: Similarity
messages: Belongs to the peptidase C48 family.

7227:Dmel CG18801
gene id: 7227:Dmel_CG18801
uniprot id: Q9I7M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

7227:Dmel CG11949
gene id: 7227:Dmel_CG11949
uniprot id: H5V8A7
uniprot id: Q9V8R9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.
messages: At onset of germ band retraction, expression is seen in epidermis, hindgut and foregut. During retraction, expression extends to tracheal branches and salivary glands.
messages: Expressed weakly in 4-8 hours embryos, more abundant expression in 8-12 hours and remains throughout later embryonic and larval stages.
messages: adherens junction
messages: septate junction

7227:Dmel CG6414
gene id: 7227:Dmel_CG6414
uniprot id: Q9W4N5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG11202
gene id: 7227:Dmel_CG11202
uniprot id: Q9W3F4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG1646
gene id: 7227:Dmel_CG1646
uniprot id: Q7KRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP39 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

7227:Dmel CG7926
gene id: 7227:Dmel_CG7926
uniprot id: A0A0B4KHW0
uniprot id: A4V3M5
uniprot id: B7Z0S0
uniprot id: Q8IMJ7
uniprot id: Q9V407
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).
messages: Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.
messages: Ubiquitously expressed throughout the development.

7227:Dmel CG3830
gene id: 7227:Dmel_CG3830
uniprot id: Q26366
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the developing wing primordia initially along the D/V wing boundary, and by the late third larval instar, maximal expression is seen in cells at the D/V wing disk boundary. Less expression is seen in cells located farther from this boundary.
messages: Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr, may control genes involved in DNA replication.
messages: Loss of vestigial function selectively eliminates wing and haltere formation.
messages: Nucleus
messages: The Ser-rich protein domain within the C-terminal region interacts with the C-terminus of sd to form a complex which acts as a selector for wing development. Interacts with Dhfr.

7227:Dmel CG2993
gene id: 7227:Dmel_CG2993
uniprot id: A0A0B4KGD9
uniprot id: A0A0B4KGR0
uniprot id: Q9VHZ7
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG11447
gene id: 7227:Dmel_CG11447
uniprot id: Q9VDT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

7227:Dmel CG34072
gene id: 7227:Dmel_CG34072
uniprot id: C7DZL0
uniprot id: P84345
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

7227:Dmel CG32169
gene id: 7227:Dmel_CG32169
uniprot id: B7Z063
uniprot id: M9NDB5
uniprot id: M9NG33
uniprot id: M9PCV2
uniprot id: Q9VVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm
messages: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

7227:Dmel CG4465
gene id: 7227:Dmel_CG4465
uniprot id: Q9VDS2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3450
gene id: 7227:Dmel_CG3450
uniprot id: Q9V998
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG18609
gene id: 7227:Dmel_CG18609
uniprot id: Q6NN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG3182
gene id: 7227:Dmel_CG3182
uniprot id: Q7JPB9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG13907
gene id: 7227:Dmel_CG13907
uniprot id: Q9W0L6
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5313
gene id: 7227:Dmel_CG5313
uniprot id: Q9VKW3
names: Similarity
messages: Belongs to the activator 1 small subunits family.

7227:Dmel CG32412
gene id: 7227:Dmel_CG32412
uniprot id: Q9VRQ9
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

7227:Dmel CG33880
gene id: 7227:Dmel_CG33880
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG32006
gene id: 7227:Dmel_CG32006
uniprot id: Q8IMA2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG12400
gene id: 7227:Dmel_CG12400
uniprot id: Q9VQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

7227:Dmel CG7787
gene id: 7227:Dmel_CG7787
uniprot id: Q9VLP3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basal cell membrane
messages: Belongs to the DSS4/MSS4 family.
messages: Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells. This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE.
messages: Interacts with Rab8.
messages: RNAi-mediated knockdown in follicle cells results in the apical localization of the basal membrane (BM) proteins trol and vkg. Results in the apical secretion of vkg, which associates with the apical plasma membrane with an adherent organization. No effect of the localization of proteins involved in intracellular trafficking such as aPKC, dlg and arm.
messages: The name stratum (strat) refers to the geological term for a layer of rock as mutants accumulate basal membrane proteins as a continuous apical sheet/layer. The name also highlights the similarity of the mislocalization phenotype to Crag mutant cells, as both names are based upon geological descriptions of rock formations.

7227:Dmel CG4312
gene id: 7227:Dmel_CG4312
uniprot id: A0A0B4LHD1
uniprot id: P11956
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 5 family.
messages: Expressed predominantly in embryonic and larval stages.
messages: Strongly induced by cadmium, copper and mercury.
messages: This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.

7227:Dmel CG12235
gene id: 7227:Dmel_CG12235
uniprot id: Q9VWE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

7227:Dmel CG12752
gene id: 7227:Dmel_CG12752
uniprot id: A0A1B2AKG3
uniprot id: Q9V3H8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in female gonads (at protein level).
messages: Forms a complex with RanGAP, Nup358/RanBP2 and sbr/Nxf1 (PubMed:14729961). In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). Interacts with nxf2 (via NTF2 domain); the interaction is direct and prevents Nxt1 binding to nucleoporins (PubMed:31368590). Interacts with sbr/nxf1 (PubMed:31570835). Interacts with Nup54 and Nup58 (PubMed:33856346).
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus
messages: Nucleus envelope
messages: RNAi-mediated knockdown in the germline increases transposon expression.
messages: Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346).

7227:Dmel CG10101
gene id: 7227:Dmel_CG10101
uniprot id: Q9VIA5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9318
gene id: 7227:Dmel_CG9318
uniprot id: Q9VIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

7227:Dmel CG44837
gene id: 7227:Dmel_CG44837
uniprot id: Q29R20
uniprot id: R9PY29
uniprot id: X2JCU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7227:Dmel CG3149
gene id: 7227:Dmel_CG3149
uniprot id: Q9Y123
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

7227:Dmel CG9499
gene id: 7227:Dmel_CG9499
uniprot id: Q9VME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG1361
gene id: 7227:Dmel_CG1361
uniprot id: A0A0B4LHV6
uniprot id: P21663
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the andropin family.
messages: Ejaculatory duct of adult males.
messages: In response to mating.
messages: Male-specific peptide with moderate activity against Gram-positive bacteria.
messages: Secreted

7227:Dmel CG31611
gene id: 7227:Dmel_CG31611
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG7358
gene id: 7227:Dmel_CG7358
uniprot id: Q9VWN4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:29535189, PubMed:29555755). In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:29535189, PubMed:29555755).
messages: Belongs to the ZC3H13 family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:29535189, PubMed:29555755).
messages: Expression is enriched in early embryos, decreases during larval stages, and rises again at pupal stages (PubMed:29555755). Strongly expressed during the maternal-to-zygotic transition, a time where N6-methyladenosine (m6A) methylation of mRNAs is decreasing (PubMed:29535189).
messages: Female-specific lethality, associated with sexual transformation phenotypes (PubMed:29555755). Hemizygous males are sterile (PubMed:29555755). Sexual transformation phenotypes resemble other N6-methyladenosine (m6A) factors, such as sexual transformations, Sxl splicing defect, held-out wings, flightless flies and reduction of m6A levels (PubMed:29555755).
messages: Nucleus
messages: Was named Xiong after the Chinese character for maleness.
messages: Widely expressed during embryogenesis but shows enrichment in the neuroectoderm.

7227:Dmel CG14670
gene id: 7227:Dmel_CG14670
uniprot id: A0A0B4KF92
uniprot id: A0A0B4LGM5
uniprot id: A0A0B4LGS6
uniprot id: Q9VNC3
names: Similarity
messages: Belongs to the biotin--protein ligase family.

7227:Dmel CG6576
gene id: 7227:Dmel_CG6576
uniprot id: Q9VSP8
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

7227:Dmel CG11874
gene id: 7227:Dmel_CG11874
uniprot id: Q9VAP8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7227:Dmel CG2890
gene id: 7227:Dmel_CG2890
uniprot id: M9PGT6
uniprot id: Q9W2U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Probably part of a PP4 PPP4C-PPP4R2-PPP4R3 complex containing Pp4-19C, PPP4R2r and flfl.

7227:Dmel CG43347
gene id: 7227:Dmel_CG43347
uniprot id: B7Z141
uniprot id: M9PE86
uniprot id: Q9W2T1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3632
gene id: 7227:Dmel_CG3632
uniprot id: A0A023GPV6
uniprot id: A8JV04
uniprot id: Q7YU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

7227:Dmel CG11921
gene id: 7227:Dmel_CG11921
uniprot id: A0A0B4LHW8
uniprot id: P32028
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in 5-12 hours embryos.
messages: Expressed in early embryogenesis in 14 symmetrical pairs of segmentally arranged neuroblasts. Also, later in embryogenesis, in a cluster of cells in head region.
messages: Involved in development during embryogenesis.
messages: Nucleus

7227:Dmel CG4007
gene id: 7227:Dmel_CG4007
uniprot id: Q9V6K3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Cell membrane
messages: Expressed at high levels in embryos and larvae, low levels in adults and pupae show maximal expression.
messages: Expressed in neural cell lineage from embryonic stage 11 onwards, resulting in expression in the brain and ventral nerve cord at the end of embryogenesis.
messages: Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

7227:Dmel CG1539
gene id: 7227:Dmel_CG1539
uniprot id: A0A0B4K6N4
uniprot id: A0A0B4K7R6
uniprot id: A0A0B4KHF2
uniprot id: A0A0B4KHW6
uniprot id: A8JRH3
uniprot id: C7LAH8
uniprot id: E1JJ21
uniprot id: O46231
uniprot id: Q9VA56
uniprot id: Q9VA58
uniprot id: Q9VA59
names: Subcellular Location Annotation
messages: cytoskeleton

7227:Dmel CG44328
gene id: 7227:Dmel_CG44328
uniprot id: G4LU05
uniprot id: Q9VYC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11967
gene id: 7227:Dmel_CG11967
uniprot id: A0A0B4LGX6
uniprot id: Q9VHJ5
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG13888
gene id: 7227:Dmel_CG13888
uniprot id: M9PGM7
uniprot id: Q9W0M2
uniprot id: X2JCA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in sweet sensing neurons of classical chemosensory sensilla, but also in two supersensitive neurons of atypical taste sensilla.
messages: Membrane
messages: One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior.
messages: Plays a role in the sugar gustatory response.

7227:Dmel CG6781
gene id: 7227:Dmel_CG6781
uniprot id: Q9VSL3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Appears only at the late pupal stage; expressed at high level. Also expressed in the early adult (0-2 days old) at lower level. Expressed exclusively in the adult head.
messages: Belongs to the GST superfamily. Omega family.
messages: Homodimer.
messages: Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8-tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.
messages: Sepia eye color, due to defects in 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA) synthesis, a key intermediate in red eye pigment drosopterin biosynthesis.

7227:Dmel CG6297
gene id: 7227:Dmel_CG6297
uniprot id: Q9V3I5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in vitro.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Chromosome
messages: Interacts with lola. Interacts with proteins of the male specific lethal (MSL) dosage compensation complex; this interaction is mediated by the kinase domains.
messages: Nucleus
messages: Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A.

7227:Dmel CG31094
gene id: 7227:Dmel_CG31094
uniprot id: A0A0B4KHW9
uniprot id: A0A0B4KI25
uniprot id: A8JRD0
uniprot id: A8JRD1
uniprot id: A8JRD2
uniprot id: E1JIX9
uniprot id: Q6NP71
uniprot id: Q9VBN0
uniprot id: Q9VBN1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

7227:Dmel CG9964
gene id: 7227:Dmel_CG9964
uniprot id: Q9VQD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG7830
gene id: 7227:Dmel_CG7830
uniprot id: Q8SY53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG13097
gene id: 7227:Dmel_CG13097
uniprot id: Q9VLK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

7227:Dmel CG4972
gene id: 7227:Dmel_CG4972
uniprot id: Q9VKZ7
names: Similarity
messages: Belongs to the nicastrin family.

7227:Dmel CG9032
gene id: 7227:Dmel_CG9032
uniprot id: Q9VXN2
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels.
messages: Although related to the eukaryotic ATPase epsilon family, there is no evidence for a function in the ATP synthase complex.
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Embryonic lethal. Heterozygotes show increased lifespan and enhanced resistance to oxidative stress. ATP levels are normal.

7227:Dmel CG5508
gene id: 7227:Dmel_CG5508
uniprot id: Q8IMM7
uniprot id: Q8IMM8
uniprot id: Q9Y137
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

7227:Dmel CG16827
gene id: 7227:Dmel_CG16827
uniprot id: Q9V7A4
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin alpha chain family.
messages: Expressed in lamellocytes (at protein level). At the anterior end of the oocyte, expressed in the follicle cells that will form the operculum and the micropyle.
messages: Heterodimer of an alpha and a beta subunit. Alpha-PS4 associates with beta-PS (By similarity).
messages: Intron retention.
messages: Membrane
messages: Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length.
messages: Weakly expressed during late-oogenesis.

7227:Dmel CG12789
gene id: 7227:Dmel_CG12789
uniprot id: Q9VM10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG31320
gene id: 7227:Dmel_CG31320
uniprot id: Q8INF7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNAAF5 family.
messages: Cytoplasm
messages: Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
messages: Dynein axonemal particle
messages: Expressed in chordonotal neurons during their differentiation, after neuronal specification but before cilium formation. Also expressed in the non-ciliated mesoderm of stage 12 embryos.
messages: Expressed in testis.
messages: Homozygous deletion-mutant flies are not viable. The larvae are smaller but do not display obvious morphological phenotype. RNAi-mediated knockdown in sensory neurons affects flies movement coordination and impairs hearing. Testis-specific RNAi-mediated knockdown does not alter spermatogenesis and in particular the formation of sperm axonemes but it impairs sperm motility.

7227:Dmel CG30189
gene id: 7227:Dmel_CG30189
uniprot id: Q9W1V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG9187
gene id: 7227:Dmel_CG9187
uniprot id: Q9W0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

7227:Dmel CG10202
gene id: 7227:Dmel_CG10202
uniprot id: A1Z9V3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

7227:Dmel CG8884
gene id: 7227:Dmel_CG8884
uniprot id: Q960T2
names: Tissue Specificity
messages: Expressed specifically in neurons and transported to synaptic terminals.

7227:Dmel CG8889
gene id: 7227:Dmel_CG8889
uniprot id: A0A0B4LF50
uniprot id: A0A0B4LG64
uniprot id: A1Z8S4
uniprot id: Q8T085
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Membrane

7227:Dmel CG4896
gene id: 7227:Dmel_CG4896
uniprot id: A0A023GRW3
uniprot id: Q8IPW6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG11561
gene id: 7227:Dmel_CG11561
uniprot id: P91682
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Expressed at all developmental stages, though the levels vary.
messages: Interacts with cos.
messages: It is uncertain whether Met-1, Met-9, Met-13 or Met-14 is the initiator.
messages: Phosphorylation by CkIalpha and PKA regulates smo accumulation at the cell surface and its signaling activity in response to hh.
messages: RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora. Abolishes Cad99C-dependent formation of endosomes and DUOX-dependent up-regulation of reactive oxygen species (ROS) in the intestines of adults fed bacteria-derived uracil.
messages: Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

7227:Dmel CG11459
gene id: 7227:Dmel_CG11459
uniprot id: Q9VNK6
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG45057
gene id: 7227:Dmel_CG45057
uniprot id: M9NFZ9
uniprot id: Q9VV43
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TPPP family.
messages: Embryonic nervous system defects characterized by cell misplacement and errors in axonal extension and targeting (PubMed:27422099). Neurons display defective axonal extension (PubMed:27422099). Defects are probably caused by impaired microtubule organization and integrity (PubMed:27422099). During larval neuromuscular junction (NMJ) synaptic development, larvae show reduced synaptic growth and transmission (PubMed:31156389). Flies lacking both Ringer and Futsch display a significant reduction in microtubule loops at the neuromuscular junctions (NMJ) and reduced acetylated-tubulin levels (PubMed:31156389).
messages: Found in a complex with tubulin and Futsch.
messages: Highly expressed in adult head (at protein level).
messages: Mainly expressed in neurons and later in midline glia during ventral nerve cord (VNC) development (at protein level).
messages: Presynapse
messages: Regulator of microtubule required for axonal extension during embryonic development (PubMed:27422099). Promotes microtubule bundling and polymerization (PubMed:27422099). Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389).
messages: axon
messages: cytoskeleton

7227:Dmel CG10367
gene id: 7227:Dmel_CG10367
uniprot id: E1JIU8
uniprot id: P14773
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresponding to the developing gonadal mesoderm. Not expressed in pole cells.
messages: Membrane
messages: Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm.
messages: The activity of HMG-CoA-reductase is suppressed by exogenous mevalonate.

7227:Dmel CG1695
gene id: 7227:Dmel_CG1695
uniprot id: Q8IQ31
names: Similarity
messages: Belongs to the RUTBC family.

7227:Dmel CG8273
gene id: 7227:Dmel_CG8273
uniprot id: Q9VHB0
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in ovarian nurse cells (at protein level).
messages: Nucleus
messages: RNA-binding protein that protects nascent transcripts containing intronic transposable sequences, known as INE-1, from being degraded by DIP1 (PubMed:31730657). Modulates DIP1 activity by repressing its sumoylation levels (PubMed:31730657). This ensures that intronic sequences will be degradated only after splicing (PubMed:31730657). In the ovaries, regulates germline stem cells (GSCs) self-renewal by repressing the expression of the GSC differentiation-promoting factor Rga (PubMed:29887366).
messages: Results in a progressing reduction in egg laying accompanied by a decrease in number of germline stem cells (GSCs) (PubMed:29887366). In the ovaries, results in an increase of Rga pre-mRNA (PubMed:29887366). Results in a decrease in the levels and stability of mRNA and INE-1-containing pre-RNA (PubMed:31730657). Might reduce levels of DIP1 sumoylation (PubMed:31730657). RNAi-mediated knockdown in the germline results in loss of GSCs (PubMed:29887366).

7227:Dmel CG5663
gene id: 7227:Dmel_CG5663
uniprot id: Q9VG79
names: Similarity
messages: Belongs to the peptidase M24B family.

7227:Dmel CG9695
gene id: 7227:Dmel_CG9695
uniprot id: P98081
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds the SH3 domains of drk via the Pro-rich domain. When phosphorylated, can interact with the SH2 domains of drk. Binds sev via the phosphotyrosine interaction domain (PID).
messages: Cytoplasm
messages: Embryonic axonogenesis.
messages: Intron retention.
messages: Probably phosphorylated by the Abl tyrosine kinase. Phosphorylated on tyrosine residues in response to sevenless activation.
messages: Together with Abl, involved in embryonic neural development. May have a role in eye development. Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling.
messages: Uniformly expressed in the embryo from blastoderm through gastrulation. Highly expressed in the mesoderm and CNS during germ-band retraction. CNS expression is later localized to axon bundles. Detected in the embryonic PNS and body wall muscles. Expressed in the eye at the morphogenetic furrow and in developing photoreceptor cells posterior to the furrow.

7227:Dmel CG42267
gene id: 7227:Dmel_CG42267
uniprot id: Q9VRA9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG17045
gene id: 7227:Dmel_CG17045
uniprot id: Q9VFV3
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG34413
gene id: 7227:Dmel_CG34413
uniprot id: A0A0B4LGJ7
uniprot id: A6MHQ4
uniprot id: B5RJJ9
uniprot id: E1JGW7
uniprot id: Q86BN4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Expressed in the brain.
messages: Flies are not viable. However, the decreased expression due to gene disruption leads to a temperature-sensitive phenotype with paralysis at 38 degrees Celsius.
messages: Induces a small but significant sodium conductance when expressed in Xenopus oocytes.
messages: Interacts with nrv1.
messages: Membrane

7227:Dmel CG10627
gene id: 7227:Dmel_CG10627
uniprot id: Q9VTZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

7227:Dmel CG3458
gene id: 7227:Dmel_CG3458
uniprot id: O96651
uniprot id: X2JEB4
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Expressed during the first 6 hours of embryonic development, levels decline during larval and pupal stages to increase again during adulthood.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA.

7227:Dmel CG6844
gene id: 7227:Dmel_CG6844
uniprot id: P17644
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: CNS in embryos.
messages: Cell membrane
messages: Late embryonic and late pupal stages.
messages: Postsynaptic cell membrane

7227:Dmel CG1584
gene id: 7227:Dmel_CG1584
uniprot id: Q9Y1B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC6 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
messages: Nucleus
messages: ORC is composed of six subunits.

7227:Dmel CG1785
gene id: 7227:Dmel_CG1785
uniprot id: Q9W3C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.
messages: nucleolus
messages: nucleoplasm

7227:Dmel CG31148
gene id: 7227:Dmel_CG31148
uniprot id: Q9VCJ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

7227:Dmel CG33101
gene id: 7227:Dmel_CG33101
uniprot id: A0A0B4LH53
uniprot id: P54351
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Nervous system and secretory tissues.
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity).
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
messages: The highest levels are detected in embryos before and during cellularization. After onset of gastrulation the highest levels of expression appear in embryonic regions that give rise to endodermal and ectodermal tissues including the midgut and hindgut.

7227:Dmel CG6800
gene id: 7227:Dmel_CG6800
uniprot id: Q9VD82
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG9623
gene id: 7227:Dmel_CG9623
uniprot id: P12080
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the integrin alpha chain family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar (at protein level). The relative ratio of isoform 1/PS2C and isoform 2/PS2M8 varies widely during development.
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.
messages: In ovaries, highly expressed in follicle cells. At syncytial blastoderm stage, expressed in the embryonic mesodermal precursors but not in the ectoderm. At embryonic stages 7 and 10, expression is restricted to the mesoderm. At stage 12, expressed in the gonadal sheath and the interstitial cells of the gonad. In stage 16 embryos, expressed in the somatic and visceral muscles where localizes to sites of attachment between adjacent muscles. In third larval instar wing imaginal disk, expressed in the ventral compartment and in a subset of adepithelial and peripodial cells (at protein level).
messages: Lateral cell membrane
messages: The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.

7227:Dmel CG12298
gene id: 7227:Dmel_CG12298
uniprot id: A0A0B4LGW1
uniprot id: Q9V877
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Mutant female meiotic spindles can be unipolar, multipolar or frayed with no defined poles.
messages: Required during female meiosis for bipolar spindle formation in the absence of the centrosomes and chromosome homolog segregation. Also has roles in male meiosis and mitotic divisions of the early embryo.
messages: cytoskeleton

7227:Dmel CG31928
gene id: 7227:Dmel_CG31928
uniprot id: Q9VQ11
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG5249
gene id: 7227:Dmel_CG5249
uniprot id: M9PBR0
uniprot id: Q9VRN4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5954
gene id: 7227:Dmel_CG5954
uniprot id: Q9VB52
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG18408
gene id: 7227:Dmel_CG18408
uniprot id: A1Z866
uniprot id: A1Z870
uniprot id: Q7K1M7
uniprot id: Q86P80
uniprot id: Q966U7
names: Subcellular Location Annotation
messages: focal adhesion

7227:Dmel CG4943
gene id: 7227:Dmel_CG4943
uniprot id: Q9V853
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subunit
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.
messages: Flies exhibit lethal defects in hindgut morphogenesis.
messages: Interacts with phosphorylated MAD.
messages: Uniformly expressed at blastoderm stage. Weakly but broadly expressed at later stages of embryogenesis.

7227:Dmel CG12029
gene id: 7227:Dmel_CG12029
uniprot id: Q9VZN4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Highly enriched in the peripheral nervous system but is absent from the central nervous system (PubMed:21368042). Expressed in neurons with more than one dendrite including da neurons, bd neurons and the dmd1 neuron but undetectable in neurons with single dendrites such as external sensory organ neurons and chodonotal neurons (PubMed:26490864).
messages: Nucleus
messages: Severely reduced growth of microtubule-based dendritic branches and elevated levels of microtubule-severing protein spas (PubMed:21368042). Gradual conversion of multipolar neurons into the bipolar or unipolar morphology (PubMed:26490864).
messages: Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042). Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864).

7227:Dmel CG11984
gene id: 7227:Dmel_CG11984
uniprot id: Q95RX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KCMF1 family.
messages: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK.
messages: Interacts with poe.

7227:Dmel CG7242
gene id: 7227:Dmel_CG7242
uniprot id: Q9V3V7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis (PubMed:17895365, PubMed:17333235). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:17895365, PubMed:17333235). Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics (PubMed:17333235). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
messages: Belongs to the SPC25 family.
messages: Component of the Ndc80 complex, which is composed of Ndc80, Nuf2 and Spc25.
messages: Die as late third-instar larvae. Mitotic neuroblasts in larval brains exhibit high levels of aneuploidy: chromosome alignment is compromised during spindle formation, many chromosomes display persistent mono-orientation which leads to aneuploidy during anaphase. Chromosome behavior is also disrupted during both meiotic divisions in spermatocytes: the entire chromosome complement often moves to only one spindle pole.
messages: Nucleus
messages: kinetochore

7227:Dmel CG9662
gene id: 7227:Dmel_CG9662
uniprot id: E0R7Q5
uniprot id: Q9VQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7227:Dmel CG1572
gene id: 7227:Dmel_CG1572
uniprot id: Q9VYX8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1048
gene id: 7227:Dmel_CG1048
uniprot id: P09090
uniprot id: Q0IGT0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.

7227:Dmel CG5621
gene id: 7227:Dmel_CG5621
uniprot id: A0A0B4KHJ0
uniprot id: Q0KI38
uniprot id: Q9VDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG4404
gene id: 7227:Dmel_CG4404
uniprot id: Q9VYI4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13298
gene id: 7227:Dmel_CG13298
uniprot id: A0A1B2AK42
uniprot id: Q9VRV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B6 family.
messages: Component of splicing factor SF3B complex (PubMed:18981222). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity).
messages: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (By similarity).
messages: Nucleus

7227:Dmel CG17762
gene id: 7227:Dmel_CG17762
uniprot id: A4V4D2
uniprot id: Q9VYK5
uniprot id: Q9VYK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7227:Dmel CG2046
gene id: 7227:Dmel_CG2046
uniprot id: Q9VNI4
names: Similarity
messages: Belongs to the PSMG1 family.

7227:Dmel CG16954
gene id: 7227:Dmel_CG16954
uniprot id: Q9VJX7
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

7227:Dmel CG33872
gene id: 7227:Dmel_CG33872
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG33253
gene id: 7227:Dmel_CG33253
uniprot id: M9PI06
uniprot id: Q8MZ13
uniprot id: X2JFR0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7227:Dmel CG2925
gene id: 7227:Dmel_CG2925
uniprot id: O46106
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Noisette' means 'hazel nut' in French, and is due to the small size of testes in mutants.
messages: Belongs to the SF3A3 family.
messages: Expressed throughout embryogenesis from syncytial blastoderm stage.
messages: Nucleus
messages: Probable component of a the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
messages: Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility.
messages: Ubiquitous. In ovaries and testes, it is expressed in all germ and somatic cells. Highly expressed in spermatogonias and spermatocytes. Highly expressed in the germ cells of larval testes, while it is weakly expressed in fat body cells, in polyploid nuclei of salivary glands, and in larval brain.

7227:Dmel CG7123
gene id: 7227:Dmel_CG7123
uniprot id: P11046
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required for Ndg localization to the basement membrane (PubMed:30260959).
messages: Domains VI and IV are globular.
messages: Found in the basement membranes (major component).
messages: In the larva, expressed mainly by fat body adipocytes and blood cells and secreted in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level).
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: Results in strong reduction of Ndg accumulation at the basement membrane in the gut, muscles and ventral nerve cord (PubMed:30260959). RNAi-mediated knockdown in the larvae reduces Ndg accumulation and created holes in the basal membrane of fat bodies (PubMed:30260959).
messages: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
messages: basement membrane

7227:Dmel CG3757
gene id: 7227:Dmel_CG3757
uniprot id: A0A4V1G8Q9
uniprot id: P09957
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major royal jelly protein family.
messages: Controls the pigmentation pattern of the adult cuticle and larval mouth parts.
messages: Flies fail to pigment the adult cuticle and larval mouth parts and show reduced level of locomotor activity and male competitive mating ability.
messages: Required during the later half of pupal development for the normal pigmentation of the adult cuticle.
messages: Secreted

7227:Dmel CG8709
gene id: 7227:Dmel_CG8709
uniprot id: A0A0B4JCQ5
uniprot id: A0A0B4JD00
uniprot id: A0A0B4JD27
uniprot id: A0A0B4JD31
uniprot id: A8DY69
uniprot id: I0E2I4
uniprot id: Q8SXP0
names: Similarity
messages: Belongs to the lipin family.

7227:Dmel CG8893
gene id: 7227:Dmel_CG8893
uniprot id: M9PJN8
uniprot id: P07487
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

7227:Dmel CG1873
gene id: 7227:Dmel_CG1873
uniprot id: A4V3Q6
uniprot id: P05303
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7227:Dmel CG9946
gene id: 7227:Dmel_CG9946
uniprot id: P41374
uniprot id: X2JFR6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Phosphorylation of eIF-2-alpha impairs the recycling of eIF-2 between successive rounds of initiation and thus leads to inhibition of translation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region.

7227:Dmel CG3041
gene id: 7227:Dmel_CG3041
uniprot id: Q24168
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Cause death late in larval development, with defects in cell-cycle progression and chromosome condensation in mitosis.
messages: Chromosome
messages: Component of the origin recognition complex (ORC) that binds origins of replication (PubMed:11137005). DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far (PubMed:11137005). ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (PubMed:11137005). As part of the ORC complex, might also have a role in mRNA export (Probable).
messages: Detected in embryos (at protein level).
messages: Nucleus
messages: ORC is composed of six subunits. Interacts with Mcm10 (PubMed:12808023). Interacts with CG9890 (PubMed:30713769). Interaction between the TREX-2/AMEX complex and the ORC complex is required for ORC localization to mRNPs, and consequently mRNA export (PubMed:27016737).
messages: centromere

7227:Dmel CG42338
gene id: 7227:Dmel_CG42338
uniprot id: B7Z145
uniprot id: E1JJM6
uniprot id: M9NF26
uniprot id: M9PJK5
uniprot id: Q9VYN8
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Expressed in the developing antennal lobe. Expressed in subset of matching olfactory receptor neurons (ORN) and projection neurons (PN) in select glomeruli between 12 to 48 hours after puparium formation (apf) (at protein level).
messages: Homodimer. Heterodimer with Ten-m; the interaction occurs at the neuromuscular junction.
messages: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with ten-m to organize neuromuscular synapses.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane
messages: axon
messages: synaptosome

7227:Dmel CG13204
gene id: 7227:Dmel_CG13204
uniprot id: A1Z8K2
uniprot id: Q6NNF8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG6921
gene id: 7227:Dmel_CG6921
uniprot id: Q9VCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG8497
gene id: 7227:Dmel_CG8497
uniprot id: Q9XYY9
names: Similarity
messages: Belongs to the RHPN family.

7227:Dmel CG6341
gene id: 7227:Dmel_CG6341
uniprot id: A0A0B4LFL3
uniprot id: O96827
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, beta' and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
messages: Phosphorylation affects the GDP/GTP exchange rate.

7227:Dmel CG7003
gene id: 7227:Dmel_CG7003
uniprot id: Q9VUM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Heterodimer of Msh2/Spel and Msh6.
messages: Involved in post-replicative DNA-mismatch repair.

7227:Dmel CG4636
gene id: 7227:Dmel_CG4636
uniprot id: F2FB81
uniprot id: H5V8D0
uniprot id: M9NCT2
uniprot id: M9PCP4
uniprot id: Q9VKM2
uniprot id: X2J5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

7227:Dmel CG18177
gene id: 7227:Dmel_CG18177
uniprot id: Q95SX8
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.
messages: Does not show histone acetyltransferase activity toward free histones.
messages: Shows histone acetyltransferase activity toward free histones.

7227:Dmel CG33129
gene id: 7227:Dmel_CG33129
uniprot id: Q9VKM7
uniprot id: Q9VKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG5446
gene id: 7227:Dmel_CG5446
uniprot id: M9PBA6
uniprot id: Q9VK90
names: Similarity
messages: Belongs to the HSBP1 family.

7227:Dmel CG4087
gene id: 7227:Dmel_CG4087
uniprot id: M9PBK5
uniprot id: P08570
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

7227:Dmel CG4280
gene id: 7227:Dmel_CG4280
uniprot id: Q27367
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Croquemort' means literally 'the one who bites dead persons' in French and is colloquial for undertaker.
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Expressed on hemocytes/macrophages in embryogenesis (PubMed:8630729). First detected in late stage 11 embryos, which corresponds to the first wave of apoptosis (PubMed:8630729). Expressed in cells that by stage 12 spread throughout the embryo and by stage 13/14 have migrated from both ends towards the middle until they are evenly distributed by stage 15 (PubMed:8630729). In L3 instar larvae, expression increases with development in the gastric caeca, midgut, Garland cells and anterior testis (PubMed:21948708). In the ovary expression appears to be restricted to one pole (PubMed:21948708). Expressed in the ring gland, and weak expression in the salivary glands and the central nervous system (PubMed:21948708).
messages: Found on hemocytes from hemolymph, and later in the development, on macrophages that contain apoptotic cell corpses.
messages: Macrophage receptor for apoptotic cells.
messages: N-glycosylated and/or O-glycosylated.

7227:Dmel CG3966
gene id: 7227:Dmel_CG3966
uniprot id: P15425
uniprot id: Q540W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Expressed specifically in photoreceptor cells.
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.

7227:Dmel CG10733
gene id: 7227:Dmel_CG10733
uniprot id: Q9VRU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

7227:Dmel CG5229
gene id: 7227:Dmel_CG5229
uniprot id: M9NEW2
uniprot id: Q9VM15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7227:Dmel CG12301
gene id: 7227:Dmel_CG12301
uniprot id: Q9VUR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

7227:Dmel CG32217
gene id: 7227:Dmel_CG32217
uniprot id: Q9VW51
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELL/occludin family.
messages: Chromosome
messages: Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear. Component of the little elongation complex, at least composed of Ell, Eaf, Ice1 and Ice2. Associates with RNA polymerase II.
messages: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:11689450). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780).
messages: Expressed in salivary glands (at protein level).
messages: Nucleus
messages: nucleolus

7227:Dmel CG7457
gene id: 7227:Dmel_CG7457
uniprot id: Q9VSA4
uniprot id: T2GGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome
messages: Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1.
messages: nucleoplasm

7227:Dmel CG5075
gene id: 7227:Dmel_CG5075
uniprot id: Q9VK47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.

7227:Dmel CG4975
gene id: 7227:Dmel_CG4975
uniprot id: B7YZJ4
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

7227:Dmel CG33236
gene id: 7227:Dmel_CG33236
uniprot id: Q7KV12
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG10781
gene id: 7227:Dmel_CG10781
uniprot id: P23938
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant only during the third larval stage.
messages: Salivary gland specific.
messages: Secreted
messages: To NG-2, also to SGS-3.

7227:Dmel CG7639
gene id: 7227:Dmel_CG7639
uniprot id: Q5BI33
uniprot id: Q9V784
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the SAM50/omp85 family.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: May play a role in the maintenance of the structure of mitochondrial cristae.
messages: Mitochondrion outer membrane

7227:Dmel CG16738
gene id: 7227:Dmel_CG16738
uniprot id: P32030
uniprot id: Q961V5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the posterior half of each parasegment just anterior to the parasegmental boundary.
messages: Nucleus
messages: Present at 0-3 hours of embryogenesis. Maximal expression at 3-6 hours. Strong re-expression in first-instar larvae.
messages: Transcription factor involved in segmentation. Required for the formation of the mandibular lobe. Different levels of slp activity seem to be required in different segments.

7227:Dmel CG30476
gene id: 7227:Dmel_CG30476
uniprot id: Q8ML92
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: 'Aveugle' means 'blind' in French.
messages: Cytoplasm
messages: Expressed ubiquitously throughout development.
messages: Interacts with the SAM domain of cnk.
messages: Membrane
messages: Required for normal photoreceptor differentiation between Ras and Raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation. Probably acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase.

7227:Dmel CG8098
gene id: 7227:Dmel_CG8098
uniprot id: A0A0B4LFK0
uniprot id: D6W4V4
uniprot id: Q9V7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: May be an inorganic phosphate cotransporter.
messages: Membrane

7227:Dmel CG14593
gene id: 7227:Dmel_CG14593
uniprot id: Q4V622
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly expressed in larval brain (PubMed:24098432, PubMed:26020940). Also highly expressed in adult brain with very low levels in larval and adult gut (PubMed:24098432).
messages: Receptor for the neuropeptide CCHamide-2.
messages: Reduced levels of insulin-like peptide Ilp5 mRNA, reduced secretion of Ilp2 and Ilp5 proteins in mid-L3 larvae, growth defects and developmental delay during larval stages.
messages: Very low expression in eggs. Expression increases during the first and second instar larval stages, decreases in the third instar larval stage, increases again in pupae and decreases slightly in adults.

7227:Dmel CG5998
gene id: 7227:Dmel_CG5998
uniprot id: Q9VVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7227:Dmel CG1751
gene id: 7227:Dmel_CG1751
uniprot id: B4F5U4
uniprot id: Q9VYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit twr/SEC11 and three accessory subunits Spase12/SPCS1, Spase25/SPCS2 and Spase22-23/SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG18616
gene id: 7227:Dmel_CG18616
uniprot id: A0A126GUU0
uniprot id: Q9V3G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
messages: Component of the CCR4-NOT complex. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG6827
gene id: 7227:Dmel_CG6827
uniprot id: Q8IQH0
uniprot id: Q94887
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Found in septate junctions of epithelial and glial cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
messages: The C-terminal region interacts with coracle. Interacts with Patj in cis form. Forms a complex with Nrg and Cont.
messages: septate junction

7227:Dmel CG14791
gene id: 7227:Dmel_CG14791
uniprot id: Q9W585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

7227:Dmel CG9372
gene id: 7227:Dmel_CG9372
uniprot id: Q9VW19
names: Similarity
messages: Belongs to the peptidase S1 family. CLIP subfamily.

7227:Dmel CG4942
gene id: 7227:Dmel_CG4942
uniprot id: Q9VST8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

7227:Dmel CG4074
gene id: 7227:Dmel_CG4074
uniprot id: Q4V3Q0
uniprot id: Q9VPC3
names: Similarity
messages: Belongs to the VPS26 family.

7227:Dmel CG34182
gene id: 7227:Dmel_CG34182
uniprot id: A8DYY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

7227:Dmel CG2998
gene id: 7227:Dmel_CG2998
uniprot id: Q9W334
uniprot id: X2JEM4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

7227:Dmel CG11661
gene id: 7227:Dmel_CG11661
uniprot id: A8JNU6
uniprot id: Q8IQQ0
uniprot id: Q9VVC5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

7227:Dmel CG7959
gene id: 7227:Dmel_CG7959
uniprot id: M9PGT9
uniprot id: Q24040
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus
messages: Regulates the DNA-binding properties of Runt.

7227:Dmel CG5430
gene id: 7227:Dmel_CG5430
uniprot id: P54185
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Cells at the bases of a few scattered sensilla on the posterior surface of the antenna.
messages: Secreted

7227:Dmel CG5137
gene id: 7227:Dmel_CG5137
uniprot id: M9PI92
uniprot id: Q9VVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Membrane
messages: Microsome membrane

7227:Dmel CG4500
gene id: 7227:Dmel_CG4500
uniprot id: Q9V3U0
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
messages: In Norse mythology, Heimdall is the fictional character that for ages guarded the bridge to Asgard without sleeping and without the consequences of sleep deprivation.
messages: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104).
messages: Results in neurodegeneration in the central nervous system including degeneration of lamina and retina, defects in the fenestrated basement membrane, ommatidial disarray, locomotor defects and shortened lifespan (PubMed:26893370, PubMed:29739804). The phenotype is exacerbated in constant light conditions and improves in total darkness (PubMed:29739804). Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs) (PubMed:29739804). Feeding the fly mutant with medium-chain fatty acids, blocks the accumulation of excess VLCFAs as well as development of the pathology (PubMed:29739804). Simultaneous knockout of bgm results in enhanced retinal degeneration and altered fatty acids metabolism (PubMed:26893370). RNAi-mediated knockdown in the adult results in reduction of triglycerides and altered neuronal function, including altered sleep rebound following sleep deprivation (PubMed:25409104).

7227:Dmel CG2709
gene id: 7227:Dmel_CG2709
uniprot id: O76908
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in nurse cell and pro-oocytes (at protein level).
messages: High levels of X chromosome non-disjunction at the first meiotic division, severe failure to initiate DNA double-strand breaks in oocytes in early pachytene and complete failure of meiotic recombination.
messages: May interact with itself and with narya and nenya through their RING-type zinc fingers.
messages: Required for the formation of DNA double-strand breaks during meiosis together with narya and nenya.
messages: The name 'vilya' derives from the fact that this protein contains a RING-type zinc finger and vilya is the mightiest of the three rings of power given by the elves of Eregion in J.R.R. Tolkien's books.

7227:Dmel CG17161
gene id: 7227:Dmel_CG17161
uniprot id: O61661
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Expressed both maternally and zygotically. Maternally supplied mRNA is degraded during progression from nuclear stage 12 to nuclear stage 13. Zygotic expression is seen at reduced levels later in embryogenesis and during larval development. Higher expression is seen in pupae, coincident with ovarian differentiation. May be activated during the syncytial blastoderm divisions which precede cellularization, the Drosophila equivalent of the mid-blastula transition (MBT). Developmentally regulated activation of the DNA replication checkpoint may occur as the nucleo-cytoplasmic ratio increases and maternal replication factors are depleted. Elongation of the embryonic cell cycle may allow time for the transcription of genes that initiate the switch from maternal to zygotic control of embryogenesis.
messages: In the germline, simultaneous RNAi-mediated knockdown of grp and Rtel1 results in partial rescue of loss of germline stem cell observed in the single Rtel1 knockdown.
messages: Nucleus
messages: Phosphorylated in a MEI-41/ATR dependent manner in response to DNA damage or the presence of unreplicated DNA.
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression.

7227:Dmel CG1234
gene id: 7227:Dmel_CG1234
uniprot id: Q9VI82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

7227:Dmel CG5029
gene id: 7227:Dmel_CG5029
uniprot id: P91931
uniprot id: Q58CK1
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (By similarity).

7227:Dmel CG10805
gene id: 7227:Dmel_CG10805
uniprot id: Q9VM75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
messages: nucleolus

7227:Dmel CG6703
gene id: 7227:Dmel_CG6703
uniprot id: A0A0B4KH39
uniprot id: E1JIS7
uniprot id: Q24210
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.
messages: In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Increases synapse-specific, activity-dependent autophosphorylation of CaMKII Thr-287.
messages: Interacts with eag. Interacts with CaMKII.
messages: May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.
messages: Probable cloning artifact.

7227:Dmel CG11563
gene id: 7227:Dmel_CG11563
uniprot id: Q9V9U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

7227:Dmel CG9704
gene id: 7227:Dmel_CG9704
uniprot id: P23654
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during embryogenesis and larvae.
messages: In the C-terminal section; belongs to the type-B carboxylesterase/lipase family.
messages: Late in embryogenesis, expression is restricted to cells of the peripheral and central nervous system undergoing proliferation and differentiation. Also expressed in larval CNS, mesoderm and imaginal disks.
messages: May mediate or modulate cell adhesion between embryonic cells during development.
messages: Membrane

7227:Dmel CG10576
gene id: 7227:Dmel_CG10576
uniprot id: Q9VRP2
names: Similarity
messages: Belongs to the peptidase M24 family.

7227:Dmel CG8415
gene id: 7227:Dmel_CG8415
uniprot id: A0A0B4LFD9
uniprot id: Q8T3U2
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Hydroxylation at Pro-62 affects translation termination efficiency.
messages: Rough endoplasmic reticulum
messages: cytosol

7227:Dmel CG8563
gene id: 7227:Dmel_CG8563
uniprot id: Q9VS64
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG33116
gene id: 7227:Dmel_CG33116
uniprot id: Q9VIU4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7227:Dmel CG5367
gene id: 7227:Dmel_CG5367
uniprot id: Q9VKY4
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG12076
gene id: 7227:Dmel_CG12076
uniprot id: Q9VZQ1
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Contaminating sequence.
messages: Mutant flies survive until adulthood but exhibit flight defects and poor locomotion (PubMed:27919077, PubMed:27919081, PubMed:28675155). Flies display sexual transformations dues to Sxl splicing defects (PubMed:27919081, PubMed:28675155).
messages: Nucleus
messages: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:27919077, PubMed:27919081, PubMed:28675155). Acts by acting as a reader of m6A methylation (PubMed:27919077, PubMed:27919081). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:27919081, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077).

7227:Dmel CG8500
gene id: 7227:Dmel_CG8500
uniprot id: Q9VH66
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9528
gene id: 7227:Dmel_CG9528
uniprot id: B5RIN0
uniprot id: M9PB50
uniprot id: Q9VMD6
names: Developmental Stage
names: RNA Editing
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected from at stage 7, where it is expressed in the early germ band. By stage 11, when the germ band is fully extended, it is expressed strongly in the ventral neuroectoderm, which represents the progenitor of the CNS. At this time, a small region of particularly strong expression is visible at the tip of the extended germ band marking the proctodeum (the primordial hindgut) and expression is also visible in the anterior midgut and the foregut primordial region known as the stomodeum. Expression then persists in both the emerging gut and nervous system during the next three developmental stages (12-14). Strong expression in the primordial midgut is rapidly down-regulated prior to stage 15, by when the presumptive midgut has closed both ventrally and dorsally and is largely established. However, expression persists in the hindgut as it continues to develop by projecting towards the antero-dorsal region of the embryo and is also evident in differentiating components of the foregut, which might include the stomatogastric nervous system. Interestingly, it is expressed strongly throughout the developing CNS and the intensity of this staining is maintained through stage 16 during major periods of developmental reorganization, while expression in regions of the gut is rapidly down-regulated. Expression continues in the CNS late into stage 17, but is also clearly reduced by the end of stage 17 immediately prior to hatching. Expressed during all subsequent developmental stages from first instar larvae through to adulthood.
messages: Mitochondrion
messages: Partially edited. Target of Adar.
messages: Restricted to the developing gut and central nervous system (CNS).

7227:Dmel CG9345
gene id: 7227:Dmel_CG9345
uniprot id: Q9VFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7227:Dmel CG40470
gene id: 7227:Dmel_CG40470
uniprot id: Q7PLV6
names: Similarity
messages: Belongs to the peptidase M1 family.

7227:Dmel CG1676
gene id: 7227:Dmel_CG1676
uniprot id: Q9VR99
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CACTIN family.
messages: Cytoplasm
messages: Expressed during embryogenesis (at protein level).
messages: Expressed in ovary (at protein level).
messages: Interacts with cact.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Plays a role during early embryonic development (PubMed:10842059). Involved in the dorsal-ventral embryonic patterning (PubMed:10842059). Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway (PubMed:10842059).

7227:Dmel CG42279
gene id: 7227:Dmel_CG42279
uniprot id: Q9VVI3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: According to some authors (PubMed:12165468) it is involved in axon guidance by promoting ubiquitination of comm and subsequent endocytosis of the comm/robo complex. However, according to others (PubMed:15657595), it is not the case.
messages: Cytoplasm
messages: Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.
messages: Interacts (via WW2 domain) with comm (via PY-motifs) (PubMed:12165468, PubMed:16531238). Interacts with N (PubMed:15620649).
messages: Ubiquitously expressed.

7227:Dmel CG6720
gene id: 7227:Dmel_CG6720
uniprot id: P52485
uniprot id: Q541C3
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.

7227:Dmel CG32164
gene id: 7227:Dmel_CG32164
uniprot id: M9PFR8
uniprot id: Q9VV82
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG11523
gene id: 7227:Dmel_CG11523
uniprot id: Q9VNV2
names: Similarity
messages: Belongs to the GSKIP family.

7227:Dmel CG5144
gene id: 7227:Dmel_CG5144
uniprot id: Q9VST4
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

7227:Dmel CG10673
gene id: 7227:Dmel_CG10673
uniprot id: Q9VRJ6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

7227:Dmel CG3647
gene id: 7227:Dmel_CG3647
uniprot id: M9PD57
uniprot id: M9PDG3
uniprot id: P40798
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NFX1 family.
messages: Major expression is seen in the ovaries while moderate levels of expression are observed during embryogenesis and throughout subsequent stages of fly development.
messages: Nucleus
messages: Ovaries and embryonic central nervous system.
messages: Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo.

7227:Dmel CG11290
gene id: 7227:Dmel_CG11290
uniprot id: Q9W1A9
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

7227:Dmel CG7506
gene id: 7227:Dmel_CG7506
uniprot id: Q95SS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM70 family.
messages: Mitochondrion membrane

7227:Dmel CG2929
gene id: 7227:Dmel_CG2929
uniprot id: Q8I0B7
uniprot id: Q9VND3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

7227:Dmel CG4618
gene id: 7227:Dmel_CG4618
uniprot id: Q9VRJ5
names: Similarity
messages: Belongs to the SNF7 family.

7227:Dmel CG6659
gene id: 7227:Dmel_CG6659
uniprot id: Q9VWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

7227:Dmel CG9319
gene id: 7227:Dmel_CG9319
uniprot id: Q9VIK0
names: Similarity
messages: Belongs to the CoA-transferase III family.

7227:Dmel CG7199
gene id: 7227:Dmel_CG7199
uniprot id: M9MS41
uniprot id: Q24142
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Binds to direct repeats of the sequence 5'-AGGTCA-3'. Inhibits the ecdysone response. Plays an essential role in regulating molting of the tracheal cuticle during larval development.
messages: By 20-hydroxyecdysone (20HE) 106 hours after egg laying.
messages: Death during the larval stages, due to defects in tracheal development characterized by fluid filling of the second instar tracheae. Mutant larvae that survive into the third instar are smaller than wild-type larvae and fail to pupariate.
messages: Highest expression in third instar larvae and prepupae.
messages: Homodimer.
messages: May be due to a competing acceptor splice site.
messages: Nucleus

7227:Dmel CG42673
gene id: 7227:Dmel_CG42673
uniprot id: Q8SXX4
names: Function
names: Tissue Specificity
messages: Expressed at higher level in wing imaginal disk.
messages: Putative adapter protein.

7227:Dmel CG14999
gene id: 7227:Dmel_CG14999
uniprot id: P53034
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Defects in mitotic chromosome cohesion and condensation due to aberrant checkpoint control in response to DNA replication inhibition or damage to chromosomes; premature chromosome condensation and precocious sister chromatid separation figures.
messages: Expressed in early embryos.
messages: Heteropentamer of subunits of 140/145, 40, 38, 37, and 36.5 kDa that forms a complex with PCNA in the presence of ATP.
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP.

7227:Dmel CG5651
gene id: 7227:Dmel_CG5651
uniprot id: Q9VSS1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCE family.
messages: Cytoplasm
messages: Expressed in early and late larval imaginal disks (at protein level).
messages: Interacts with components of eIF3 complex, namely eIF3a, eIF3j, eIF3b, eIF3c and eIF3i (PubMed:17392269). Associates with the 40S ribosome subunit in an ATP-dependent manner and independently from the presence of the eIF3 complex (PubMed:17392269). Forms a complex with Git and Pak; the interaction with Pak may be mediated by pix/dPIX (PubMed:18996366).
messages: Plays a role in translation initiation and quality control of translation (PubMed:16291791, PubMed:17392269, PubMed:29861391). Together with pelo and HBS1, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:17392269). Stabilizes core components of eIF3 complex promoting their assembly into translation initiation-competent complexes (PubMed:17392269). Together with pelo and HBS1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:25128630). Plays a role in the regulation of mRNA turnover (By similarity). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the Pink1-regulated signaling, ubiquitinated by Cnot4 upon mitochondria damage; this modification generates polyubiquitin signals that recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). Required in the wing disk for cell division and growth as well as cell survival (PubMed:16291791). During muscle embryogenesis, required for the recruitment of Pak to muscle attachments in the embryo, hence may play a role in proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes (PubMed:18996366).
messages: The ABC transporter 2 domain is necessary and sufficient for association to the 40S ribosome subunit.
messages: Ubiquitinated by Cnot4 (PubMed:29861391). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (PubMed:29861391).

7227:Dmel CG8105
gene id: 7227:Dmel_CG8105
uniprot id: Q9VXS8
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG8874
gene id: 7227:Dmel_CG8874
uniprot id: A0A0B4KFK7
uniprot id: A0A0B4KGK6
uniprot id: P18106
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 53% of mutants die during embryogenesis with the remainder dying during larval and pupal development. In embryos the rate of dorsal closure is reduced and complete closure is delayed until after stage 16. During dorsal closure, filopodia are normal but the actomyosin cable is reduced and the leading edge cells have an irregular morphology. After dorsal closure, a very small percentage of embryos display a small anterior hole in their cuticle. Reduced phosphorylation of arm.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Expressed during all stages of development.
messages: Expressed in a subset of cells in the embryonic central nervous system (CNS) (PubMed:16831834). In the embryo, expressed in leading edge cells of the dorsal epidermis (at protein level) (PubMed:16831834). Expressed in many tissues during embryonic development, some expression is transient and absent from most of nervous system (PubMed:1898762). In the embryo, strong expression in the leading edge cells from late stage 13 and throughout dorsal closure to the end of stage 15 (PubMed:16831834). In the embryonic CNS, expressed in the midline glia from stage 13, and by stage 16 expressed in a segmentally repeated subset of cells and in the dMP2 neurons (PubMed:16831834). Larvae exhibit expression in neural tissues and graded expression in all imaginal disks (PubMed:1898762). Pupal expression is seen in muscles and varies during development (PubMed:1898762). Expression in adults is strong in the retina and present in ovaries, no expression is present in the adult brain (PubMed:1898762).
messages: Membrane
messages: Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm.
messages: adherens junction

7227:Dmel CG6660
gene id: 7227:Dmel_CG6660
uniprot id: Q9VCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG9943
gene id: 7227:Dmel_CG9943
uniprot id: Q9U4F3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Lethal at larval stage (PubMed:16172499). Larvae show reduced locomotor speed and response to light (PubMed:16172499). Results in smaller muscle fibers with mitochondria defects (PubMed:16172499). RNAi-mediated knockdown is lethal at larval stage (PubMed:25164807). RNAi-mediated knockdown in the developing CNS, in the eye and antenna disk from early larval stages shows increased lifespan with reduction of COX activity, increased succinate dehydrogenase (SDH) activity, reduced locomotor speed and response to light (PubMed:16172499, PubMed:25164807). RNAi-mediated knockdown in mesodermal derivatives from early embryonic stages to pupal metamorphosis is lethal at pupal stage with muscles showing enlarged and disorganized mitochondria and reduced activity of all mitochondrial respiratory chain complexes (PubMed:25164807).
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

7227:Dmel CG2173
gene id: 7227:Dmel_CG2173
uniprot id: Q7JQN4
names: Similarity
messages: Belongs to the DEAD box helicase family.

7227:Dmel CG8013
gene id: 7227:Dmel_CG8013
uniprot id: Q9NJG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
messages: Component of the Esc/E(z) complex, composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho. The Esc/E(z) complex may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.
messages: Nucleus
messages: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.

7227:Dmel CG12345
gene id: 7227:Dmel_CG12345
uniprot id: P07668
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
messages: The 54 kDa and 13 kDa chains exist as a heterodimer.
messages: The N-terminus of choline O-acetyltransferase 67 kDa and 54 kDa chains are blocked.

7227:Dmel CG6863
gene id: 7227:Dmel_CG6863
uniprot id: Q9VC47
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3331
gene id: 7227:Dmel_CG3331
uniprot id: Q9VDC6
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NRP synthetase family.
messages: Cytoplasm
messages: Expressed in the optic neuropils in the lamina and in distinct cells at the distal border of the medulla cortex (at protein level) (PubMed:9852943, PubMed:12205712, PubMed:17678856, PubMed:19715698). Expressed in the protocerebrum and thoracic ganglia (at protein level) (PubMed:17678856). Expressed in antennal lobes, antennal nerves and subesophagic ganglion (at protein level) (PubMed:19715698). Specifically, expressed in epithelial glial cells of the medulla that surround the synaptic cleft of photoreceptor axonal endings (at protein level) (PubMed:12205712, PubMed:17678856, PubMed:19715698). Expressed in some cells in the cuticle (PubMed:9852943).
messages: Expression begins in embryos at stage 13 in two cells of each of the abdominal segments 1 to 7 (at protein level) (PubMed:12205712). Expressed at the third larval instars in the glia (at protein level) (PubMed:12205712, PubMed:17678856). Transiently expressed in the integument of late embryos at stage 14-15 (at protein level) (PubMed:19715698). Expressed in embryonic trachea from stage 11 until stage 15 (at protein level) (PubMed:19715698). In the second and third larval instars, expressed at the periphery and in cells within the brain hemispheres arranged in a crescent-shaped structure (at protein level) (PubMed:9852943, PubMed:12205712, PubMed:25229196). In the ventral ganglion, expressed in cells arranged in two rows: one on each side of the ventral nerve cord (at protein level) (PubMed:9852943, PubMed:12205712). Also expressed in the anterior and posterior spiracles (at protein level) (PubMed:12205712). During pupal stages, no expression between 24 and 60 hours after puparium formation (at protein level) (PubMed:11934851, PubMed:12205712). Expression resumes 60 hours after puparium formation in the lamina neuropil, in single cells at the distal border of the medulla and in some cells of the deeper lobula and lobula plate neuropils (at protein level) (PubMed:12205712). In pharate adults, just before eclosion, expressed in epidermal cells; expression levels are similar in all cells that secrete the abdominal tergites (at protein level) (PubMed:11934851). In pharate adults, expressed in the esophagus epidermis and in the ommatidia lens cuticle (at protein level) (PubMed:19715698).
messages: In the brain, expressed with a circadian rhythm with high levels at the beginning of day and low levels at night (at protein level).
messages: May also use Mn(2+).
messages: Nonribosomal peptide synthase which is required for the regulation of histamine and dopamine levels in various tissues through their condensation with beta-alanine (PubMed:12900414, PubMed:19715698, PubMed:25229196, PubMed:30705105). In epithelial glial cells, plays an essential role in the inactivation of histamine, the main neurotransmitter in the optical nerve system, by catalyzing the conversion of histamine into carcinine (PubMed:5782111, PubMed:12486147, PubMed:12900414, PubMed:25229196, PubMed:30705105). In the cuticle, catalyzes the condensation of beta-alanine with dopamine to form beta-alanyl-dopamine (NBAD), a metabolite involved in the pigmentation and sclerotization of the insect cuticle (PubMed:8580497, PubMed:11934851). Also, regulates the cuticular hydrocarbon composition in females (PubMed:31118901). Acts downstream of the body clock to regulate circadian behavioral rhythms (PubMed:17678856). Can also condense beta-alanine with biogenic amines tyramine, octopamine, and serotonin in vitro (PubMed:12900414, PubMed:19715698).
messages: Reduced histamine levels in the head; specifically, in the central brain, beneath the basement membrane and in proximity to the lamina neuropil (PubMed:12486147). Fewer synaptic vesicles in the terminals of R1-R6 photoreceptors (PubMed:12486147). Loss of carcinine production in the head (PubMed:12486147). Photoreceptor response to light is abnormal (PubMed:5782111). Electroretinogram (ERG) recordings lack 'on' and 'off' transients probably due to an impaired synaptic transmission to postsynaptic cells (PubMed:5782111). Induces a darker pigmentation of the body (PubMed:11934851, PubMed:31118901). The pigment stripe near the posterior edge of each abdominal tergite is darker compared to wild type (PubMed:11934851). Ectopic pigmentation in the thorax and in the wings (PubMed:11934851). In newly emerged female imagoes and fly frass, beta-alanyl-dopamine (NBAD) levels are reduced and dopamine levels are elevated about 2-fold (PubMed:8580497). Females have lower levels of short chain hydrocarbons (CHC) (less than 25C) and higher levels of long chain CHCs (more than 25C) (PubMed:31118901). RNAi-mediated knockdown in oenocytes has no effect on the length of CHC (PubMed:31118901).
messages: The nonribosomal peptide synthase is composed of three domains. The adenylation (A) domain is responsible for the adenylation and activation of beta-alanine using ATP (PubMed:12900414, PubMed:25229196). The thiolation (T) or peptidyl carrier protein domain (PCP) contains the prosthetic group 4'-phosphopantetheine, which activated beta-alanyl-AMP is transferred to via thiolation (PubMed:12900414, PubMed:25229196). The condensation (C) domain both performs the selection of the amine substrate, dopamine or histamine, and the condensation of these amines with beta-alanine via an amide bond (PubMed:12900414, PubMed:25229196, PubMed:30705105).
messages: e/ebony expression levels vary across D.melanogaster population in the wild, affecting both pigmentation and chain hydrocarbon length profiles.

7227:Dmel CG11188
gene id: 7227:Dmel_CG11188
uniprot id: Q9VM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: May function as a general inhibitor of the histone deacetylase HDAC1.
messages: Nucleus

7227:Dmel CG17210
gene id: 7227:Dmel_CG17210
uniprot id: Q9VGQ4
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG8920
gene id: 7227:Dmel_CG8920
uniprot id: E1JGN5
uniprot id: Q0E910
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG3527
gene id: 7227:Dmel_CG3527
uniprot id: Q9W4J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
messages: nucleolus

7227:Dmel CG5849
gene id: 7227:Dmel_CG5849
uniprot id: E1JIS5
uniprot id: Q9VD87
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG7293
gene id: 7227:Dmel_CG7293
uniprot id: M9PF68
uniprot id: P46867
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
messages: Expressed primarily in the central nervous system and in a subset of the peripheral nervous system during embryogenesis.
messages: Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.
messages: cytoskeleton

7227:Dmel CG2054
gene id: 7227:Dmel_CG2054
uniprot id: D0IQG7
uniprot id: Q9W092
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG1397
gene id: 7227:Dmel_CG1397
uniprot id: Q9VZ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG5643
gene id: 7227:Dmel_CG5643
uniprot id: Q9VB23
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7227:Dmel CG6415
gene id: 7227:Dmel_CG6415
uniprot id: Q9VKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

7227:Dmel CG3849
gene id: 7227:Dmel_CG3849
uniprot id: Q8I7C3
names: Subunit
messages: Interacts with osk.

7227:Dmel CG43365
gene id: 7227:Dmel_CG43365
uniprot id: B7Z045
uniprot id: M9PE48
uniprot id: M9PH51
uniprot id: Q960S0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7528
gene id: 7227:Dmel_CG7528
uniprot id: Q7KUA4
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

7227:Dmel CG18673
gene id: 7227:Dmel_CG18673
uniprot id: Q9V9Y6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG10816
gene id: 7227:Dmel_CG10816
uniprot id: P36193
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antibacterial peptide with strong anti-Gram-negative bacteria activity.
messages: Belongs to the drosocin family.
messages: By bacterial infection (at protein level) (PubMed:9736738). In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks (at protein level) (PubMed:9736738).
messages: Expressed in larvae and in adults.
messages: Hemolymph (at protein level).
messages: O-glycosylated (PubMed:8325867, PubMed:9888811, PubMed:9736738). O-glycosylation is essential for full biological activity (PubMed:8325867).
messages: Secreted

7227:Dmel CG11622
gene id: 7227:Dmel_CG11622
uniprot id: Q9VDG2
names: Function
names: RNA Editing
names: Sequence Caution
names: Subunit
messages: Interacts with CycB and numb.
messages: Intron retention.
messages: Partially edited. Target of Adar.
messages: Participates in receptor endocytosis during interphase, is also involved in mitotic processes when endocytosis is switched off.

7227:Dmel CG30340
gene id: 7227:Dmel_CG30340
uniprot id: A1Z7X3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG10347
gene id: 7227:Dmel_CG10347
uniprot id: Q9VYT5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG14616
gene id: 7227:Dmel_CG14616
uniprot id: Q9VR59
uniprot id: X2JCY0
uniprot id: X2JEN2
uniprot id: X2JG41
uniprot id: X2JGE9
uniprot id: X2JLN4
names: Caution
names: Domain
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: Partially edited. Target of Adar.
messages: The N-terminal kinase domain produces inositol polyphosphates. The C-terminal acid phosphatase-like domain binds inositol polyphosphates and negatively regulates their accumulation. The C-terminal domain reduces the amount of inositol pyrophosphates in a dose-dependent manner in vitro.
messages: cytosol

7227:Dmel CG15706
gene id: 7227:Dmel_CG15706
uniprot id: Q8MRB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7227:Dmel CG32280
gene id: 7227:Dmel_CG32280
uniprot id: Q8IRE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG6012
gene id: 7227:Dmel_CG6012
uniprot id: Q9VJG8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG6272
gene id: 7227:Dmel_CG6272
uniprot id: Q9VTE8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5009
gene id: 7227:Dmel_CG5009
uniprot id: B5RIN5
uniprot id: Q7KML2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acyl-CoA oxidase family.
messages: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.
messages: Expressed in glia.
messages: Homodimer.
messages: Most mutants die as pupae. They have increased VLCFA, loss of vision and have glial loss and reduced neuronal survival.
messages: Nucleus
messages: Peroxisome

7227:Dmel CG12744
gene id: 7227:Dmel_CG12744
uniprot id: Q7JUR5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

7227:Dmel CG43073
gene id: 7227:Dmel_CG43073
uniprot id: A0A0B4JCX2
uniprot id: A0A0B4JDC9
uniprot id: A0A0B4KG12
uniprot id: A0A0B4KGQ6
uniprot id: A0A126GUV2
uniprot id: E1JIL7
uniprot id: Q86BP0
uniprot id: Q86BS0
uniprot id: Q9VF66
names: Similarity
messages: Belongs to the RIMBP family.

7227:Dmel CG15104
gene id: 7227:Dmel_CG15104
uniprot id: Q9V8P9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina.
messages: Interacts with h/hairy, p53 and Top1. Interacts with the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw); interacts directly with mod(mdg4) and su(Hw). Interacts with Lam/lamin.
messages: Nucleus

7227:Dmel CG18039
gene id: 7227:Dmel_CG18039
uniprot id: Q9TVI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG8458
gene id: 7227:Dmel_CG8458
uniprot id: Q9VFX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.
messages: In contrast to other members of the family, it is not lipidated.
messages: extracellular matrix

7227:Dmel CG9455
gene id: 7227:Dmel_CG9455
uniprot id: A1Z6R4
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG5375
gene id: 7227:Dmel_CG5375
uniprot id: A8DYY6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the SCHIP1 family.
messages: Death during embryonic or early larval stages. Inactivation in adult eyes results in enlarged eyes with irregular bulging on the surface.
messages: In eye disks of the third instar larvae, expressed in all cells (at protein level).
messages: Interacts with ex; the interaction results in recruitment of Schip1 to the apical cell membrane. Interacts with Tao; the interaction enhances Tao kinase activity. Interacts with Mer.
messages: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. Schip1 promotes kinase activity of Tao and enhances phosphorylation of hpo by Tao.
messages: adherens junction

7227:Dmel CG31938
gene id: 7227:Dmel_CG31938
uniprot id: Q8IPX7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP40 family.
messages: Component of the RNA exosome complex (PubMed:12490954). Specifically part of the catalytically inactive RNA exosome core complex (By similarity).
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (By similarity). In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts such as antisense RNA species, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm (By similarity). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs (By similarity). The catalytic inactive RNA exosome core complex of 9 subunits is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). Required generally for normal embryonic and neuronal development (PubMed:32645003). Also plays a critical role in the maintenance of neuronal function in mature flies by controlling the levels of specific mRNAs such as the synaptic regulator Arc1 (PubMed:32645003).
messages: Nucleus
messages: RNAi-mediated knockdown in the whole body, neurons, glia or muscles is lethal (PubMed:32645003). RNAi-mediated knockdown in mushroom bodies affects the morphology of the alpha- and beta-lobes as well as ellipsoid bodies (PubMed:32645003). RNAi-mediated knockdown in the wing pouch results in severe wing development phenotypes and increase of miR-252-5p expression (PubMed:25892215).
messages: nucleolus

7227:Dmel CG32721
gene id: 7227:Dmel_CG32721
uniprot id: Q9Y113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NELF-B family.
messages: Chromosome
messages: Component of the NELF complex.
messages: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II.
messages: Nucleus

7227:Dmel CG12602
gene id: 7227:Dmel_CG12602
uniprot id: Q9VKF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7227:Dmel CG43946
gene id: 7227:Dmel_CG43946
uniprot id: A0A0S0WFC8
uniprot id: Q8IRI6
uniprot id: X2JBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Facilitative glucose transporter.
messages: Membrane

7227:Dmel CG7769
gene id: 7227:Dmel_CG7769
uniprot id: Q9XYZ5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of the UV-DDB complex which includes DDB1 and DDB2; the heterodimer dimerizes to give rise to a heterotetramer when bound to damaged DNA (By similarity). The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit (By similarity). Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1 (By similarity). DDB1 may recruit specific substrate targeting subunits to the DCX complex (By similarity). These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity). Interacts with Fbw5 and gig (PubMed:18381890). May interact with ohgt (PubMed:27702999).
messages: Cytoplasm
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). Required for degradation of gig (PubMed:18381890). Required for genomic stability in the face of endogenous DNA lesions and for the response to MMS-induced DNA damage (PubMed:16428319). Required for normal wing development (PubMed:16428319).
messages: Reduced tissue growth in the wing imaginal disk.

7227:Dmel CG4899
gene id: 7227:Dmel_CG4899
uniprot id: B7Z061
uniprot id: Q7KNR7
uniprot id: Q8IQN8
uniprot id: Q9VV42
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG3576
gene id: 7227:Dmel_CG3576
uniprot id: Q9W423
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7227:Dmel CG14722
gene id: 7227:Dmel_CG14722
uniprot id: Q8T088
names: Similarity
messages: Belongs to the WD repeat WDR55 family.

7227:Dmel CG9073
gene id: 7227:Dmel_CG9073
uniprot id: P47948
names: Similarity
names: Tissue Specificity
messages: Accumulates almost exclusively in larval muscles.
messages: Belongs to the troponin C family.

7227:Dmel CG5836
gene id: 7227:Dmel_CG5836
uniprot id: Q9VEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

7227:Dmel CG12539
gene id: 7227:Dmel_CG12539
uniprot id: Q8SXY8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG30000
gene id: 7227:Dmel_CG30000
uniprot id: Q7K0B6
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

7227:Dmel CG34074
gene id: 7227:Dmel_CG34074
uniprot id: B6E0P7
uniprot id: P00417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG33806
gene id: 7227:Dmel_CG33806
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG9008
gene id: 7227:Dmel_CG9008
uniprot id: Q8IP67
uniprot id: Q9V3D1
uniprot id: X2JAD3
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

7227:Dmel CG3548
gene id: 7227:Dmel_CG3548
uniprot id: Q9W140
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG31691
gene id: 7227:Dmel_CG31691
uniprot id: D4G7E3
uniprot id: Q9VIR2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A humoral factor that may play a role in stress tolerance.
messages: Belongs to the Turandot family.
messages: By a variety of stressful conditions including bacterial infection, heat shock and exposure to ultraviolet light.
messages: Expressed in late embryos and disappeared by early larval states to reappear in the early pupae.
messages: Secreted

7227:Dmel CG12130
gene id: 7227:Dmel_CG12130
uniprot id: Q9V5E1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: Cell membrane
messages: N-glycosylated.
messages: Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
messages: Widely expressed. In mature larvae, it is ubiquitously expressed with a low expression in all cells and a stronger expression in a subset of neurons. Colocalizes with neuropeptide proctolin. In adults, weak expression is observed in most neuronal cell bodies and in scattered large cells throughout the protocerebrum and also in the subesophageal neuromeres (at protein level).

7227:Dmel CG15100
gene id: 7227:Dmel_CG15100
uniprot id: A1ZBE9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG30410
gene id: 7227:Dmel_CG30410
uniprot id: Q8MLS2
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

7227:Dmel CG6867
gene id: 7227:Dmel_CG6867
uniprot id: Q9VWZ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG1490
gene id: 7227:Dmel_CG1490
uniprot id: Q9VYQ8
uniprot id: X2JEX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Hydrolase that deubiquitinates target proteins.
messages: Nucleus

7227:Dmel CG5370
gene id: 7227:Dmel_CG5370
uniprot id: O02002
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.
messages: Present uniformly throughout embryos of stages 4 and 10. In stage 16 embryos, the expression becomes restricted to the central nervous system, the developing gonads, and a portion of the gut. In stage 17 embryos, expression is mainly localized in cells along the midline of the central nervous system.

7227:Dmel CG6177
gene id: 7227:Dmel_CG6177
uniprot id: Q9VF78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG2 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi morphology and function.

7227:Dmel CG4005
gene id: 7227:Dmel_CG4005
uniprot id: Q45VV3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAP1 family.
messages: Cytoplasm
messages: Interacts (via WW domains) with wts (PubMed:16096061). Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd (PubMed:18313299). The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Interacts with Ack and ex (PubMed:27462444).
messages: Its activity is regulated by multiple phosphorylation events (PubMed:16096061, PubMed:18256197, PubMed:19900439, PubMed:31857346). Phosphorylation at Ser-88, Ser-145 and Ser-227 negatively regulate its activity and restrict its nuclear localization (PubMed:19900439). Wts-mediated phosphorylation at Ser-145 promotes interaction with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Phosphorylation at Ser-88 and Ser-227 regulate nuclear localization and activity independent of 14-3-3 association (PubMed:19900439). Phosphorylation at Ser-146 by Cdk7 promotes its stability by preventing ubiquitination by the DCX(DCAF12) complex (PubMed:31857346).
messages: Named for its loss-of-function phenotype after a very small breed of dog, the Yorkshire Terrier.
messages: Nucleus
messages: Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:16096061, PubMed:18313299, PubMed:22615583, PubMed:27462444). The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein (PubMed:16096061, PubMed:19900439). The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam (PubMed:16096061, PubMed:18313299). Regulates the expression of G1/S-specific CycE and diap1, thereby promoting cell proliferation and inhibiting apoptosis (PubMed:18313299). Required for transcriptional activity of sd in wing imaginal disks (PubMed:18313299). Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f) (PubMed:18313299).
messages: Ubiquitinated by the DCX(DCAF12) complex, leading to its degradation (PubMed:31857346). Phosphorylation at Ser-146 by Cdk7 prevents ubiquitination by the DCX(DCAF12) complex (PubMed:31857346).

7227:Dmel CG5859
gene id: 7227:Dmel_CG5859
uniprot id: A1ZAK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 8 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424).
messages: Nucleus

7227:Dmel CG6295
gene id: 7227:Dmel_CG6295
uniprot id: Q9VB93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG12787
gene id: 7227:Dmel_CG12787
uniprot id: F0JAH7
uniprot id: Q8I930
uniprot id: Q9VR47
uniprot id: Q9Y163
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG31208
gene id: 7227:Dmel_CG31208
uniprot id: Q8IN58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily.
messages: Cell membrane
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG1527
gene id: 7227:Dmel_CG1527
uniprot id: C0HKA0
uniprot id: C0HKA1
uniprot id: X2JCX8
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

7227:Dmel CG10753
gene id: 7227:Dmel_CG10753
uniprot id: Q9VU02
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Interacts with the SMN complex.
messages: Methylated on arginine residues by Art5 and Art7; methylation is not required for assembly and biogenesis of snRNPs.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

7227:Dmel CG11780
gene id: 7227:Dmel_CG11780
uniprot id: Q9VBZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the transfer of galactose onto proteins or lipids.
messages: Membrane

7227:Dmel CG3423
gene id: 7227:Dmel_CG3423
uniprot id: Q9VM62
names: Similarity
messages: Belongs to the SCC3 family.

7227:Dmel CG11533
gene id: 7227:Dmel_CG11533
uniprot id: Q8IMC6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Detected at low levels throughout development. Highest expression levels are seen in embryos.
messages: Detected in larval brain.
messages: Embryonic lethal.
messages: Interacts with Mtor.
messages: Probable serine/threonine protein kinase.
messages: spindle

7227:Dmel CG3228
gene id: 7227:Dmel_CG3228
uniprot id: O46072
names: Developmental Stage
names: Miscellaneous
names: Similarity
messages: 'Kurz' means 'short' in German.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Maternal protein detectable up to 6 hours of embryonic development.

7227:Dmel CG14352
gene id: 7227:Dmel_CG14352
uniprot id: Q9VQ27
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG15027
gene id: 7227:Dmel_CG15027
uniprot id: Q9VXY4
names: Similarity
messages: Belongs to the TMA16 family.

7227:Dmel CG7259
gene id: 7227:Dmel_CG7259
uniprot id: Q9VUM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7227:Dmel CG10243
gene id: 7227:Dmel_CG10243
uniprot id: A0A0B4LFE8
uniprot id: P82711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG4659
gene id: 7227:Dmel_CG4659
uniprot id: Q9V3D9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

7227:Dmel CG1942
gene id: 7227:Dmel_CG1942
uniprot id: Q7K1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

7227:Dmel CG3061
gene id: 7227:Dmel_CG3061
uniprot id: Q9VFP0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG16753
gene id: 7227:Dmel_CG16753
uniprot id: Q9VZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

7227:Dmel CG7842
gene id: 7227:Dmel_CG7842
uniprot id: Q8T3L6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type II malonyltransferase family.
messages: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity).
messages: Eggs have a thin shell.
messages: Mitochondrion

7227:Dmel CG15218
gene id: 7227:Dmel_CG15218
uniprot id: Q961D1
names: Similarity
messages: Belongs to the cyclin family.

7227:Dmel CG11337
gene id: 7227:Dmel_CG11337
uniprot id: Q9V9X7
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

7227:Dmel CG3977
gene id: 7227:Dmel_CG3977
uniprot id: M9NE97
uniprot id: Q9W3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

7227:Dmel CG2478
gene id: 7227:Dmel_CG2478
uniprot id: Q9VIL0
uniprot id: U3PV94
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIBP family.
messages: Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells.
messages: Cytoplasm
messages: Expressed in embryos and adults of males and females.
messages: Failure of both actomyosin ring constriction and furrow ingression in male meiotic cells.
messages: Golgi apparatus
messages: May be part of the multisubunit TRAPP (transport protein particle) complex.

7227:Dmel CG11308
gene id: 7227:Dmel_CG11308
uniprot id: Q9VP40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

7227:Dmel CG6125
gene id: 7227:Dmel_CG6125
uniprot id: Q8SYW1
uniprot id: Q9VF65
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11562
gene id: 7227:Dmel_CG11562
uniprot id: Q9VPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

7227:Dmel CG6197
gene id: 7227:Dmel_CG6197
uniprot id: A1Z9G2
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the crooked-neck family.
messages: Component of the NTC(Nineteen)/Prp19 complex composed of at least fand, Prp19,CG9667/ISY1 and Cdc5/CDC5L. Within the complex, interacts with Prp19 and ISY1/CG9667.
messages: Expressed in adult ovaries and 0-3 hours embryos (at protein level).
messages: Named 'fandango' after the Iberian folk dance to highlight the similarity of the blastoderm cellularization phenotype to the charleston/kuk phenotype (PubMed:24755291). The phenotype 'faint sausage (fas)', consisting of a poorly differentiated cuticle and head, was previously associated with the immunoglobulin domain protein CG17716 but is now known to be caused by mutations in the protein 'fandango' (PubMed:24755291).
messages: Nucleus
messages: Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome (PubMed:24755291, PubMed:28087625). The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation (PubMed:24755291, PubMed:28087625). Essential for efficient pre-mRNA splicing (PubMed:24755291, PubMed:28087625). In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development (PubMed:24755291, PubMed:28087625, PubMed:10502111). Part of its role in promoting embryo tracheal development is also due to specifically splicing bnl transcripts which results in the activation of the BNL-FGF pathway (PubMed:28087625).

7227:Dmel CG4209
gene id: 7227:Dmel_CG4209
uniprot id: M9NFW6
uniprot id: P48451
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.
messages: This protein has four functional calcium-binding sites.

7227:Dmel CG12921
gene id: 7227:Dmel_CG12921
uniprot id: Q7K0A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

7227:Dmel CG14266
gene id: 7227:Dmel_CG14266
uniprot id: P40139
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant only during the third larval stage.
messages: Salivary gland specific.
messages: Secreted
messages: To NG-1, also to SGS-3.

7227:Dmel CG6277
gene id: 7227:Dmel_CG6277
uniprot id: Q9VB89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG42750
gene id: 7227:Dmel_CG42750
uniprot id: Q9VJ94
uniprot id: X2JA84
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7227:Dmel CG2239
gene id: 7227:Dmel_CG2239
uniprot id: Q9TVP3
names: Tissue Specificity
messages: Expressed in the head.

7227:Dmel CG12061
gene id: 7227:Dmel_CG12061
uniprot id: A8Y5A2
uniprot id: Q7PLW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7227:Dmel CG9882
gene id: 7227:Dmel_CG9882
uniprot id: Q9W1V1
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Death at pupal stage.
messages: Essential arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3.
messages: Expressed at low level in ovary.

7227:Dmel CG8361
gene id: 7227:Dmel_CG8361
uniprot id: P13097
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In larva, detected in the optic lobe and weakly in the neuroblasts (at protein level) (PubMed:22357926). Expressed at the time when separation of neural and epidermal precursor cells occurs (PubMed:2540957). Mesectodermal expression appears shortly before the onset of gastrulation (PubMed:2540957). In imaginal disks, expression is seen primarily within presumptive proneural clusters of eye-antennal, wing and leg disks (PubMed:2540957).
messages: Nucleus
messages: Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'.
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
messages: The orange domain and the basic helix-loop-helix motif mediate repression of specific transcriptional activators, such as basic helix-loop-helix protein dimers.
messages: Transcription repression requires formation of a complex with a corepressor protein (Groucho). Forms homodimers.

7227:Dmel CG14789
gene id: 7227:Dmel_CG14789
uniprot id: Q9W589
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families.
messages: Does not require divalent metal ions for optimal activity.
messages: Endoplasmic reticulum
messages: Golgi apparatus

7227:Dmel CG7171
gene id: 7227:Dmel_CG7171
uniprot id: P16163
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Malpighian tubules.
messages: Peroxisome
messages: Repressed by 20-hydroxyecdysone.
messages: Third instar larvae and adult.

7227:Dmel CG9364
gene id: 7227:Dmel_CG9364
uniprot id: A4UZR3
uniprot id: A5XCQ1
uniprot id: Q9W2M2
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

7227:Dmel CG9004
gene id: 7227:Dmel_CG9004
uniprot id: Q9W020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC22 family.
messages: nucleolus

7227:Dmel CG3168
gene id: 7227:Dmel_CG3168
uniprot id: Q9W3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7227:Dmel CG8924
gene id: 7227:Dmel_CG8924
uniprot id: Q9VXL5
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG32788
gene id: 7227:Dmel_CG32788
uniprot id: Q8IRT6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG17397
gene id: 7227:Dmel_CG17397
uniprot id: A0A1B2AKZ9
uniprot id: Q9W5P1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, which includes at least MED4, MED6, MED14, MED17, MED18, MED20, MED21, MED23, MED24, MED27, MED30 and MED31. Also interacts with MED7 and MED10.
messages: Component of the Mediator complex.
messages: Maternally encoded. Expression decreases during larval stages then rises during mid-pupal metamorphosis.
messages: Nucleus

7227:Dmel CG4654
gene id: 7227:Dmel_CG4654
uniprot id: A0A0B4KEQ0
uniprot id: Q24318
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the E2F/DP family.
messages: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription.
messages: Heterodimer of E2f and Dp. Cooperate to give sequence-specific DNA binding and optimal trans-activation. Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, HDAC1/Rpd3 and l(3)mbt.
messages: Nucleus

7227:Dmel CG14280
gene id: 7227:Dmel_CG14280
uniprot id: Q9VDY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17437
gene id: 7227:Dmel_CG17437
uniprot id: Q9V3J8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat WDR5/wds family.
messages: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:25310983). In neurons and together with DNA N6-methyl adenine demethylase Tet, plays a role in the maintenance of transcriptional activation for specific sets of genes (PubMed:30078725).
messages: Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722). Interacts with Set1 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6 (PubMed:21875999). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268). Interacts with Nup98 (PubMed:25310983). Interacts (via WD repeats) with Tet (via C-terminus) (PubMed:30078725).
messages: Expressed at all stages of development.
messages: Expressed in imaginal disks, larval brain, nurse cells, spermatogonia and spermatocytes.
messages: Larval lethal (PubMed:12471440). Conditional RNAi-mediated knockdown in larval wing imaginal disks results in reduced levels of trimethylated 'Lys-4' in histone H3 (PubMed:25310983). RNAi-mediated knockdown in neurons, does not affect mushroom bodies alpha lobe development (PubMed:30078725). Simultaneous RNAi-mediated knockdown of wds and Tet results in enhanced mushroom body alpha lobe development defects compared to the single Tet knockdown (PubMed:30078725).
messages: Nucleus

7227:Dmel CG9177
gene id: 7227:Dmel_CG9177
uniprot id: Q9VXK6
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).

7227:Dmel CG1084
gene id: 7227:Dmel_CG1084
uniprot id: Q9VN14
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Expressed in ectodermally derived epithelial cells from stage 12. All these tissues, such as epidermis, hindgut, foregut, salivary glands and trachea, which contain pleated septate junctions. Expressed by ectodermally derived epithelial cells and along peripheral nerves. Not present in midline glial cells. Expressed in epithelial cells and glial cells of peripheral nerves.
messages: Forms a complex with Nrg and Nrx.
messages: N-glycosylated.
messages: Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.
messages: septate junction

7227:Dmel CG10493
gene id: 7227:Dmel_CG10493
uniprot id: Q9VJ07
names: Function
messages: Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.

7227:Dmel CG4104
gene id: 7227:Dmel_CG4104
uniprot id: Q9Y119
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

7227:Dmel CG8849
gene id: 7227:Dmel_CG8849
uniprot id: Q9VMY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG17998
gene id: 7227:Dmel_CG17998
uniprot id: A0A0B4KI69
uniprot id: P32866
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adult females show severely reduced number of egg chambers and the small germarium in ovarioles. The rare eggs that become fertilized display gross defects in embryogenesis exhibiting fusion of adjacent segments and holes in the dorsal and ventral cuticle.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Expressed both maternally and zygotically.
messages: Expressed in all larval tissues and in adult ovaries. Larval CNS staining is localized to axons projecting to the optic lobes and the mushroom bodies, in the longitudinal connectives, and in cell bodies and nerves of the ring gland corpus allatum. Adult CNS staining is detectable only in cell bodies and processes associated with the ellipsoid body of the central complex and portions of the mushroom bodies. In the wing disk, expression is confined to a stripe that parallels the anterior/posterior boundary of the wing blade and the hinge region, and weak expression in the prospective notum.
messages: Membrane
messages: Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity). Required during oogenesis and embryogenesis; component of a signaling pathway that functions during egg chamber maturation.

7227:Dmel CG2044
gene id: 7227:Dmel_CG2044
uniprot id: P07189
names: Function
messages: Component of the larval cuticle.

7227:Dmel CG9265
gene id: 7227:Dmel_CG9265
uniprot id: Q9VIG6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG3638
gene id: 7227:Dmel_CG3638
uniprot id: A0A0S0X0Z7
uniprot id: A0A0S0X7W8
uniprot id: M9NEN6
uniprot id: M9PGE0
uniprot id: Q9W5A5
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Death during development.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.

7227:Dmel CG34317
gene id: 7227:Dmel_CG34317
uniprot id: A8JRG8
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

7227:Dmel CG34045
gene id: 7227:Dmel_CG34045
uniprot id: A1ZBJ7
names: Similarity
messages: Belongs to the scoloptoxin-05 family.

7227:Dmel CG14476
gene id: 7227:Dmel_CG14476
uniprot id: Q7KMM4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

7227:Dmel CG10388
gene id: 7227:Dmel_CG10388
uniprot id: D8FT40
uniprot id: P83949
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family.
messages: In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
messages: The QA motif is able to mediate transcriptional repression.

7227:Dmel CG11182
gene id: 7227:Dmel_CG11182
uniprot id: Q9W1H7
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG31053
gene id: 7227:Dmel_CG31053
uniprot id: Q8IMM9
names: Function
names: Miscellaneous
names: Subunit
messages: May interact with itself, with narya and vilya through its RING-type zinc finger.
messages: Nenya, narya and vilya contain a RING-type zinc finger domain and are named after the Three Rings of Power given by the elves of Eregion in J.R.R. Tolkien's books.
messages: Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process (PubMed:30615609). Plays a redundant role with narya in chromosome segregation during female meiosis (PubMed:30615609).

7227:Dmel CG10852
gene id: 7227:Dmel_CG10852
uniprot id: O46200
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Main cells of accessory gland and seminal fluid.
messages: Responsible for physiological and behavioral changes in mated female flies.
messages: Secreted

7227:Dmel CG18812
gene id: 7227:Dmel_CG18812
uniprot id: A0A0B4KFB9
uniprot id: Q7JUR6
names: Disruption Phenotype
names: Similarity
messages: Belongs to the GDAP2 family.
messages: Shortened lifespan, impaired locomotor behavior, and increased sensitivity to deleterious effects of stressors such as reactive oxygen species and nutrient deprivation. Locomotor anomalies include righting defects, reduced and uncoordinated walking behavior, and compromised flight.

7227:Dmel CG32751
gene id: 7227:Dmel_CG32751
uniprot id: Q8IRR1
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
messages: Expressed in third instar larvae.
messages: Induced by ethanol.
messages: Secreted

7227:Dmel CG6778
gene id: 7227:Dmel_CG6778
uniprot id: Q9VUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity). Required for terminal arborization of both dendrites and axons during development (PubMed:17529987).
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: axon

7227:Dmel CG8127
gene id: 7227:Dmel_CG8127
uniprot id: A0A0S0WIG6
uniprot id: E3CTP0
uniprot id: M9NED3
uniprot id: P13055
uniprot id: P17671
uniprot id: P17672
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.
messages: In mid instar larvae salivary glands, levels are low during puff stage 1, increase during puff stages 2-4 and diminish from stage 5 onwards. In prepupae, isoform A is the predominant form during puff stage 19 and the transition to stage 20. By stage 3 it is present in the gut, Malpighian tubules and the fat body, levels persist beyond stage 11.
messages: In mid instar larvae salivary glands, levels increase during puff stage 1, then remain relatively constant until the premetamorphic pulse of ecdysone at puff stage 5. Levels increase again in late larvae at puff stages 9-10. At puff stage 1 expression is also seen in the gut. Levels are low in the gut, Malpighian tubules, fat body and wing disks between stages 1 and 11.
messages: In mid instar larvae salivary glands, low basal levels are observed in puff stage 1. Levels increase in late larvae from puff stages 3-10, then decrease abruptly at stage 11. In prepupae, isoform C is the predominant form during the transition between puff stages 18-19. At puff stage 1, expression is also present in the gut. By stage 3 it is present in the wing disks, Malpighian tubules and the fat body. At stage 11, expression is only present in the gut and wing disks.
messages: Nucleus
messages: The expression of this protein is developmentally regulated and is correlated with the 20-OH-ecdysone induced activity of puff 75B.

7227:Dmel CG15510
gene id: 7227:Dmel_CG15510
uniprot id: Q9VAF7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0771 family.
messages: Chromosome
messages: Expressed in larva and adult male. Expression in the sperm nucleus begins between the early and late canoe stages before the protamines appear. Highly expressed from early spermatocyte to late spermatid and persists in mature sperm.
messages: Nucleus
messages: RNAi-mediated knockdown in late spermatogonia to early spermatocytes affects spermiogenesis and results in reduced male fertility. Sperm nuclei are long and needle-shaped due to the elongation of their chromatin region. No effect on the replacement of histones by protamines in the chromatin of sperm during the haploid phase of spermatogenesis.
messages: Regulates chromatin compaction in spermatid nuclei and is essential for male fertility. Functions in parallel with other chromatin-condensing proteins such as ProtA, ProtB and Mst77F.
messages: The C-terminal part (169-201) is essential for male fertility and correct chromatin compaction in mature sperm.

7227:Dmel CG13189
gene id: 7227:Dmel_CG13189
uniprot id: Q8SWW2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5841
gene id: 7227:Dmel_CG5841
uniprot id: Q9VUX2
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.
messages: Interacts with intracellular domain of Dl and Ser.
messages: Ubiquitous in the wing imaginal disk (at protein level).
messages: cell cortex

7227:Dmel CG33117
gene id: 7227:Dmel_CG33117
uniprot id: D3PFH6
uniprot id: Q8INV7
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A humoral factor that may play a role in stress tolerance.
messages: Belongs to the Turandot family.
messages: By a variety of stressful conditions including bacterial infection, heat shock and exposure to ultraviolet light.
messages: Expressed in the third larval instar and maintained through to early pupal development.
messages: Secreted

7227:Dmel CG16916
gene id: 7227:Dmel_CG16916
uniprot id: Q9V405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

7227:Dmel CG18599
gene id: 7227:Dmel_CG18599
uniprot id: Q9VEA3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4986
gene id: 7227:Dmel_CG4986
uniprot id: Q9V3J3
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Accumulates after eclosion and gradually increases during sexual maturation. In males, levels decline immediately after mating and recover progressively.
messages: Lumen fluid of male accessory glands, becomes seminal fluid.
messages: Secreted
messages: Transferred from male to female during mating and may affect egglaying and behavior after mating.
messages: cAMP-dependent phosphorylation.

7227:Dmel CG31221
gene id: 7227:Dmel_CG31221
uniprot id: A0A0B4KGY8
uniprot id: Q7JRL9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG31096
gene id: 7227:Dmel_CG31096
uniprot id: Q9VBP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG32483
gene id: 7227:Dmel_CG32483
uniprot id: Q8IRI8
names: Similarity
messages: Belongs to the peptidase S10 family.

7227:Dmel CG7059
gene id: 7227:Dmel_CG7059
uniprot id: Q86BN5
uniprot id: Q86BN6
uniprot id: Q8T8W6
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7227:Dmel CG5383
gene id: 7227:Dmel_CG5383
uniprot id: Q9VD28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase.
messages: Nucleus

7227:Dmel CG11985
gene id: 7227:Dmel_CG11985
uniprot id: A0A1B2AKC8
uniprot id: Q9VHI4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the SF3B complex (PubMed:27185460, PubMed:18981222). SF3B complex associates with the splicing factor SF3A complex and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP)(PubMed:27185460, PubMed:18981222). Identified in the SAGA transcription regulatory histone acetylation (HAT) complex; the interaction is RNA-independent (PubMed:27185460).
messages: Involved in pre-mRNA splicing as component of spliceosome (PubMed:27185460, PubMed:18981222). As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation (PubMed:27035939). When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes (PubMed:27185460).
messages: Lethal at the first instar larval stage (PubMed:27185460). RNAi-mediated knockdown in germ cells results in male sterility (PubMed:27035939).
messages: Nucleus

7227:Dmel CG4805
gene id: 7227:Dmel_CG4805
uniprot id: Q86LG1
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Cell membrane
messages: Expressed in water-sensing neurons in taste bristles on the proboscis but not in carbonation-sensing taste peg neurons (at protein level). Expressed in the tracheal system.
messages: Flies do not exhibit any general drinking defects, but do exhibit markedly reduced water-elicited proboscis extension reflex responses. Abolishes water-elicited spiking activity of water gustatory neurons.
messages: Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport.
messages: Probable cloning artifact.

7227:Dmel CG16914
gene id: 7227:Dmel_CG16914
uniprot id: P82384
names: Function
messages: Component of the cuticle of the larva.

7227:Dmel CG12367
gene id: 7227:Dmel_CG12367
uniprot id: Q7K175
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of selected small RNAs. Mediates 2'-O-methylation of piRNAs, single-stranded siRNAs and long hairpin RNA genes (hpRNAs). Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries.

7227:Dmel CG3560
gene id: 7227:Dmel_CG3560
uniprot id: Q9VXI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

7227:Dmel CG3796
gene id: 7227:Dmel_CG3796
uniprot id: P10083
names: Function
names: Subunit
names: Tissue Specificity
messages: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: L(1)SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe.

7227:Dmel CG1121
gene id: 7227:Dmel_CG1121
uniprot id: Q9VIB3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG13609
gene id: 7227:Dmel_CG13609
uniprot id: Q9VCB1
names: Caution
names: Similarity
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.

7227:Dmel CG32666
gene id: 7227:Dmel_CG32666
uniprot id: Q0KHT7
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

7227:Dmel CG5188
gene id: 7227:Dmel_CG5188
uniprot id: Q9VKV9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

7227:Dmel CG4094
gene id: 7227:Dmel_CG4094
uniprot id: Q8IRQ5
uniprot id: Q9W3X6
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

7227:Dmel CG8637
gene id: 7227:Dmel_CG8637
uniprot id: M9PG43
uniprot id: Q9NBK5
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by fry.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed in the peripheral and central nervous system (at protein level) (PubMed:15479641, PubMed:32022690). Expressed in the wing imaginal disk (PubMed:11102376).
messages: Interacts with, and is activated by, Mob1.
messages: Nucleus
messages: Results in splitting or branching of epidermal hairs, supernumerary terminal branching and defective dendritic tiling (PubMed:11102376, PubMed:15479641). RNAi-mediated knockdown in neurons increases dendrite length of sensory neurons (PubMed:32022690).
messages: Serine/threonine-protein kinase involved in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites (PubMed:11102376, PubMed:15479641, PubMed:32022690). Together with fry, maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons (PubMed:15479641). Reduces neurite outgrowth by phosphorylating pav, thereby inhibiting its function in microtubule-microtubule sliding (PubMed:32022690).

7227:Dmel CG33884
gene id: 7227:Dmel_CG33884
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG34150
gene id: 7227:Dmel_CG34150
uniprot id: Q0KI15
names: Subcellular Location Annotation
messages: Mitochondrion matrix

7227:Dmel CG13999
gene id: 7227:Dmel_CG13999
uniprot id: Q9VMK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

7227:Dmel CG1165
gene id: 7227:Dmel_CG1165
uniprot id: P37160
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Expressed only during the larval stage, the highest level is reached during the third larval instar.
messages: Found in the midgut, especially the epithelium of the gastric caeca.
messages: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.

7227:Dmel CG17579
gene id: 7227:Dmel_CG17579
uniprot id: P21520
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.
messages: Late endosome
messages: Possesses five pairs of dibasic residues that may be the target of proteolytic processing.

7227:Dmel CG10379
gene id: 7227:Dmel_CG10379
uniprot id: A0A0B4K7Q6
uniprot id: Q9VCH4
names: Similarity
messages: Belongs to the DOCK family.

7227:Dmel CG6051
gene id: 7227:Dmel_CG6051
uniprot id: A0A0B4K6M9
uniprot id: A0A0B4LHZ6
uniprot id: Q9VB70
names: Function
names: Similarity
messages: Belongs to the lst-2 family.
messages: Negative regulator of epidermal growth factor receptor (EGFR) signaling.

7227:Dmel CG43663
gene id: 7227:Dmel_CG43663
uniprot id: E1JIP2
uniprot id: Q7KSD8
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Expressed both maternally and zygotically throughout development with lowest expression levels in L2 and L3 larvae, and highest expression levels during pupal development (PubMed:12482983, PubMed:12697829). Highly expressed in all developmental stages, though its abundance decreases in L2 larvae then returns to high levels in pupae (PubMed:19921261).
messages: GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription.
messages: Interacts with Pcaf/GCN5 as part of a GCN5-containing ADA (GNAT) multiprotein complex (PubMed:12482983, PubMed:12697829). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268).
messages: Nucleus
messages: This protein is produced by a bicistronic gene which also produces the Rpb4 protein by alternative splicing.
messages: Under heat shock conditions, strongly down-regulated in L2 stage larvae with levels remaining low during the L3 and pupal stages. In second instar larvae, down-regulated 1 hr after starvation and then appears to return to normal expression levels 4 hr after nutritional starvation.

7227:Dmel CG12878
gene id: 7227:Dmel_CG12878
uniprot id: A0A0B4KH64
uniprot id: Q7KRX5
uniprot id: Q9VB04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus speckle

7227:Dmel CG5665
gene id: 7227:Dmel_CG5665
uniprot id: M9NFL7
uniprot id: Q9VPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG31692
gene id: 7227:Dmel_CG31692
uniprot id: A0A0U1RVK6
uniprot id: Q9VIS3
uniprot id: X2JES1
names: Similarity
messages: Belongs to the FBPase class 1 family.

7227:Dmel CG4001
gene id: 7227:Dmel_CG4001
uniprot id: A0A0B4K7L1
uniprot id: A0A0B4KFI7
uniprot id: C7LA80
uniprot id: H5V888
uniprot id: P52034
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nearly 90% of the PFK activity in adults is localized to the thorax.

7227:Dmel CG3619
gene id: 7227:Dmel_CG3619
uniprot id: A4V346
uniprot id: P10041
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.
messages: Detected in all areas with neurogenic abilities, for example the neurogenic ectoderm and the primordia of the sense organs. Later expression is restricted to those cells that have adopted a neural fate.
messages: Expressed both maternally and zygotically. Expression is highest early in embryonic development (stage 5) and reduces to a low level during larval stages.
messages: Interacts with N via the EGF repeats and the N EGF repeats.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.
messages: Putative Notch ligand involved in the mediation of Notch signaling.
messages: Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
messages: Ubiquitinated by Mib, leading to its endocytosis and subsequent degradation.

7227:Dmel CG13626
gene id: 7227:Dmel_CG13626
uniprot id: Q9VC58
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG45760
gene id: 7227:Dmel_CG45760
uniprot id: A8QI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

7227:Dmel CG6632
gene id: 7227:Dmel_CG6632
uniprot id: Q9VWS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7227:Dmel CG18241
gene id: 7227:Dmel_CG18241
uniprot id: Q9VLE6
names: Similarity
messages: Belongs to the Toll-like receptor family.

7227:Dmel CG6553
gene id: 7227:Dmel_CG6553
uniprot id: Q4V6B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7262
gene id: 7227:Dmel_CG7262
uniprot id: Q9VFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

7227:Dmel CG18023
gene id: 7227:Dmel_CG18023
uniprot id: M9NDE9
uniprot id: P45447
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Induces the early late puff 78C which triggers puparium formation and development.
messages: Isoform A and isoform B require ecdysone for activity. Isoform B also requires ecdysone-induced proteins for maximal expression.
messages: Isoform A is expressed only in mid-pupal stages, while isoform B is maximally expressed in newly formed prepupae and immediately following isoform A in mid-pupae.
messages: Nucleus

7227:Dmel CG1443
gene id: 7227:Dmel_CG1443
uniprot id: Q8MS59
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea.
messages: Detected in the tracheal system and hindgut from embryonic stage 13 onwards (at protein level).
messages: Tracheal morphogenesis in embryos is grossly normal. The tracheal tubes fail to fill with gas during the final stages of maturation, and instead remain full of fluid. The hydrophobic outer cuticle layer of the trachea appears to be disrupted and forms membranous structures extending into the tracheal lumen.

7227:Dmel CG3411
gene id: 7227:Dmel_CG3411
uniprot id: A0A0B4LGL8
uniprot id: B7YZQ0
uniprot id: Q24535
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After germ band retraction, high levels of zygotic expression are observed in a distinct subset of peripheral tracheal cells distributed throughout the embryo and low levels in somatic muscle. Expressed in the future intervein tissue of the wing imaginal disk from the third instar larvae until eclosion of the adult fly (at protein level).
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea.

7227:Dmel CG7361
gene id: 7227:Dmel_CG7361
uniprot id: Q9VQ29
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

7227:Dmel CG6951
gene id: 7227:Dmel_CG6951
uniprot id: L7VG69
uniprot id: Q9VWA2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Supplies the nucleotide substrate for thymidylate synthetase.

7227:Dmel CG4086
gene id: 7227:Dmel_CG4086
uniprot id: Q9V420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

7227:Dmel CG2699
gene id: 7227:Dmel_CG2699
uniprot id: Q7KTZ2
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

7227:Dmel CG2835
gene id: 7227:Dmel_CG2835
uniprot id: A0A0B4LGI1
uniprot id: P20354
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(s) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase (By similarity).
messages: Preferentially expressed in the nervous system and in the eyes.

7227:Dmel CG2286
gene id: 7227:Dmel_CG2286
uniprot id: A4V449
uniprot id: Q94511
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Complex I is composed of about 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity).
messages: Mitochondrion inner membrane

7227:Dmel CG8707
gene id: 7227:Dmel_CG8707
uniprot id: Q7K519
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

7227:Dmel CG5660
gene id: 7227:Dmel_CG5660
uniprot id: Q9VSR7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG8274
gene id: 7227:Dmel_CG8274
uniprot id: A0A0B4KFE9
uniprot id: A1Z8P9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TPR family.
messages: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:9152019). Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:12027452, PubMed:15356261). Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:12027452, PubMed:20174442). Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442). Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442). Preferentially binds to NARs of the male X chromosome (PubMed:20174442). In males, together with Nup153, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150). In males, restrains dosage-compensated expression at the level of nascent transcription probably by interacting with the MSL complex and by modulating RNA Polymerase II phosphorylation status and activity (PubMed:34133927). During mitosis forms a gel-like spindle matrix complex together with Skeletor, Chro, east, and Asator embedding the microtubule spindle apparatus (PubMed:15356261, PubMed:15962301, PubMed:19273613, PubMed:22855526). During interphase localizes Mad1 to the nuclear pore complex and thereby might act as a scaffold to assemble the Mad1-C-Mad2 complex, an heterotetramer that catalyzes the structural conversion of open-Mad2 (O-Mad2) into closed-Mad2 (C-Mad2) which is essential for spindle-assembly checkpoint (SAC) (PubMed:31913420). During the metaphase-anaphase transition and before chromosome congression, is phosphorylated by Msp-1; this modification releases Mad1 from the nuclear pore complex and thereby promotes assembly of SAC ensuring a timely and ef…
messages: Expressed at all developmental stages (PubMed:9152019). Expressed in embryos (at protein level) (PubMed:16543150).
messages: Expressed in salivary glands, fat body, tracheal tube, esophageal tube and anterior ejaculatory duct (at protein level).
messages: Midbody
messages: Mps1-mediated phosphorylation disrupts interaction with Mad1 during mitosis.
messages: Nucleus
messages: Nucleus envelope
messages: Nucleus lamina
messages: Nucleus matrix
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC) (PubMed:9152019, PubMed:12027452, PubMed:22855526). Associates with male-specific lethal (MSL) histone acetyltransferase complex (PubMed:16543150). Interacts with Mad2; the interaction is required for efficient recruitment of Mad2 to unattached kinetochore and occurs in a microtubule-independent manner (PubMed:19273613). Interacts with Mad1 (N-terminus) (PubMed:31913420). Interacts with Chro, east and Asator; the interaction is part of a macromolecular complex forming the spindle matrix during mitosis (PubMed:15356261, PubMed:15962301, PubMed:19890914). Interacts with Nup98 (PubMed:28366641). In males, interacts with histone acetyltransferase mof (PubMed:34133927).
messages: RNAi-mediated knockdown in the whole body or specifically in the germ line results in a decreased number of germinal stem cells (GSCs) in the testes (PubMed:26714316). RNAi-mediated in the testes results in mislocalization of microtubule-regulating protein Apc2 and shg/E-cadherin, defective centrosome orientation, mitotic spindle formation and chromosome segretation (PubMed:26714316). RNAi-mediated knockdown in male salivary glands increases male-specific gene expression on X chromosome and nuclear expression of roX1 and roX2, two long non-coding RNAs (lncRNAs) part of the males-specific lethal (MSL) complex (PubMed:34133927). Simultaneous RNAi-mediated knockdown of Mtor with RNAi-mediated knockdown of mof or the lncRNAs roX1 or roX2 in male salivary glands results in a rescue of up-regulated X chromosome gene expression (PubMed:34133927).
messages: The C-terminal domain is required for interchromosomal localization during interphase (PubMed:15356261). The C-terminal domain is sufficient for localization to the nuclear lamina as well as for spindle localization (PubMed:15356261).
messages: The N-terminal coiled-coil domain is required for both nuclear pore complex (NPC) and spindle matrix localization.
messages: kinetochore
messages: nuclear pore complex
messages: spindle

7227:Dmel CG7210
gene id: 7227:Dmel_CG7210
uniprot id: Q04652
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Both proteins are expressed in ovaries, male testis, ovariectomized females, cuticle, salivary gland and imaginal disks. Kelch short protein is the predominant form and is also expressed in fat bodies. On entry into metamorphosis levels of full-length protein increase in testis and imaginal disks.
messages: Component of ring canals that regulates the flow of cytoplasm between cells. May be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. Binds actin.
messages: Larvae, pupae and adults.
messages: cytoskeleton

7227:Dmel CG2254
gene id: 7227:Dmel_CG2254
uniprot id: Q9W3K9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG4604
gene id: 7227:Dmel_CG4604
uniprot id: A1Z991
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7227:Dmel CG10298
gene id: 7227:Dmel_CG10298
uniprot id: Q9VI08
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

7227:Dmel CG6488
gene id: 7227:Dmel_CG6488
uniprot id: Q9VKH0
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Intron retention.
messages: Required for normal Golgi function.

7227:Dmel CG1176
gene id: 7227:Dmel_CG1176
uniprot id: P54194
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Present only in a small number of hairs scattered over the surface of the funiculus.
messages: Secreted

7227:Dmel CG32654
gene id: 7227:Dmel_CG32654
uniprot id: A8JUU1
uniprot id: A8JUU3
uniprot id: M9PHF1
uniprot id: X2JEM2
uniprot id: X2JEY9
uniprot id: X2JJP5
names: Similarity
messages: Belongs to the SEC16 family.

7227:Dmel CG32531
gene id: 7227:Dmel_CG32531
uniprot id: Q9VWI3
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

7227:Dmel CG11648
gene id: 7227:Dmel_CG11648
uniprot id: A0A0B4KGT1
uniprot id: A0A126GUV3
uniprot id: A0A126GUV9
uniprot id: A4V304
uniprot id: P09087
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Abd-B homeobox family.
messages: Highly expressed during embryogenesis, lower expression in larvae, pupae and adults.
messages: Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7227:Dmel CG8858
gene id: 7227:Dmel_CG8858
uniprot id: Q9V677
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the proteasome.
messages: Cytoplasm

7227:Dmel CG3931
gene id: 7227:Dmel_CG3931
uniprot id: Q9W1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

7227:Dmel CG4892
gene id: 7227:Dmel_CG4892
uniprot id: Q9VJM2
names: Similarity
messages: Belongs to the CDV3 family.

7227:Dmel CG6643
gene id: 7227:Dmel_CG6643
uniprot id: A0A0B4K6F9
uniprot id: A0A0B4KGU9
uniprot id: Q7KS16
uniprot id: Q9VC62
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1044
gene id: 7227:Dmel_CG1044
uniprot id: Q9VZZ9
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development.
messages: Interacts with DRK.
messages: Membrane
messages: Phosphorylated on Tyr-801 and Tyr-854 in response to sevenless activation, which initiates the recruitment of the phosphatase CSW.
messages: Present in larva (at protein level).

7227:Dmel CG33747
gene id: 7227:Dmel_CG33747
uniprot id: A0A1B2AJ78
uniprot id: P82891
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Catalyzes the dephosphorylation of tyrosine phosphorylated proteins and low-MW aryl phosphates (PubMed:10675607). Can contribute to the regulation of a variety of developmental processes (PubMed:10675607).
messages: Cone cells and primary pigment cells in developing pupal retina.
messages: Cytoplasm
messages: Embryo and adult.

7227:Dmel CG12190
gene id: 7227:Dmel_CG12190
uniprot id: Q9W215
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8353
gene id: 7227:Dmel_CG8353
uniprot id: Q9VLR2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

7227:Dmel CG8344
gene id: 7227:Dmel_CG8344
uniprot id: P25167
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
messages: Nucleus

7227:Dmel CG12511
gene id: 7227:Dmel_CG12511
uniprot id: B6IDP6
uniprot id: Q9VMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

7227:Dmel CG10483
gene id: 7227:Dmel_CG10483
uniprot id: Q9VRR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

7227:Dmel CG12674
gene id: 7227:Dmel_CG12674
uniprot id: M9PC82
uniprot id: Q9VQ73
names: Similarity
messages: Belongs to the PAF1 family.

7227:Dmel CG6465
gene id: 7227:Dmel_CG6465
uniprot id: Q9I7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

7227:Dmel CG9543
gene id: 7227:Dmel_CG9543
uniprot id: Q9Y0Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

7227:Dmel CG13651
gene id: 7227:Dmel_CG13651
uniprot id: Q9VBW9
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Coexpressed with dan in the presumptive distal antenna, but not in the leg imaginal disk. Both proteins are also expressed in the brain and the eye region of the eye-antenna disk. First detected in early L3 eye disks in cells surrounding the newly initiated morphogenetic furrow. Highly expressed in evenly spaced clusters of cells anterior to the furrow, lower levels within and posterior to the furrow.
messages: Flies exhibit partial transformation of antenna toward leg identity. Ectopic expression causes partial transformation of distal leg structure toward antennal identity.
messages: Interacts with itself, dan, ey and dac to form a complex (or complexes) containing the RD factors.
messages: Nucleus
messages: Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.

7227:Dmel CG7402
gene id: 7227:Dmel_CG7402
uniprot id: Q9VVM4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG33203
gene id: 7227:Dmel_CG33203
uniprot id: B7Z0R3
uniprot id: Q86D34
uniprot id: Q9VAS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7227:Dmel CG43444
gene id: 7227:Dmel_CG43444
uniprot id: M9NEY8
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Binds 3 zinc ions per subunit. The zinc ions have a structural role.
messages: Chromosome
messages: Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725). N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838). Promotes differentiation of early germ cells in ovary (PubMed:25936838). Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725). By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725). Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838).
messages: Expressed in brain (at protein level).
messages: Interacts (via C-terminus) with wds (via WD repeats).
messages: Lethality at the pupa stage. A small population of mutant animals are however able to pass through the pupa stage but die within 3 days post-eclosion. Strong developmental defects and significantly increases the abundance of N(6)-methyladenosine (m6A) modification in DNA. RNAi-mediated knockdown results in mushroom bodies abnormalities, including beta-lobes which erroneously cross the midline, missing or misdirected alpha- and beta-lobes, as well as truncated or overbranched lobes (PubMed:30078725). RNAi-mediated knockdown in neurons results in mushroom body abnormalities in adult flies (PubMed:30078725). Simultaneous RNAi-mediated knockdown of Tet and wds results in enhanced mushroom body alpha lobe development defects compared to the single Tet knockdown (PubMed:30078725).
messages: Weakly expressed during early embryonic stages but is highly expressed during the later embryonic stages.

7227:Dmel CG10075
gene id: 7227:Dmel_CG10075
uniprot id: Q9VRZ7
names: Similarity
messages: Belongs to the CBP3 family.

7227:Dmel CG6706
gene id: 7227:Dmel_CG6706
uniprot id: A0A0B4LHR4
uniprot id: Q8IN24
uniprot id: Q9Y133
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG3484
gene id: 7227:Dmel_CG3484
uniprot id: P91615
uniprot id: X2JAH0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG12157
gene id: 7227:Dmel_CG12157
uniprot id: M9PGL7
uniprot id: Q9U4L6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria.
messages: Expressed both maternally and zygotically.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Interacts with mitochondrial targeting sequences (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane
messages: Ubiquitously expressed. In the male germ line expression is detected early in premeiotic spermatogonia and is persistent to the end of meiosis.

7227:Dmel CG3395
gene id: 7227:Dmel_CG3395
uniprot id: C6SUW3
uniprot id: P55935
uniprot id: Q95RG1
names: Developmental Stage
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Expressed both maternally and zygotically throughout development.

7227:Dmel CG33673
gene id: 7227:Dmel_CG33673
uniprot id: Q4ABI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7227:Dmel CG10652
gene id: 7227:Dmel_CG10652
uniprot id: Q9VJ19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

7227:Dmel CG4764
gene id: 7227:Dmel_CG4764
uniprot id: Q9VPX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

7227:Dmel CG9547
gene id: 7227:Dmel_CG9547
uniprot id: Q9VMC6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7227:Dmel CG14041
gene id: 7227:Dmel_CG14041
uniprot id: Q9V3U3
uniprot id: Q9VMV3
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

7227:Dmel CG16785
gene id: 7227:Dmel_CG16785
uniprot id: A8JUT5
uniprot id: O77438
uniprot id: X2JC46
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Expressed in embryos from stage 11 and in larvae.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
messages: The FZ domain is involved in binding with Wnt ligands.
messages: Wing, leg and eye imaginal disks. In embryos, expressed is seen in brain, proventriculus, Malpighian tubules, anal plate and visceral mesoderm of parasegment 8.

7227:Dmel CG7946
gene id: 7227:Dmel_CG7946
uniprot id: Q9VAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

7227:Dmel CG46277
gene id: 7227:Dmel_CG46277
uniprot id: T2FGB0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7227:Dmel CG5285
gene id: 7227:Dmel_CG5285
uniprot id: Q9VEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

7227:Dmel CG43722
gene id: 7227:Dmel_CG43722
uniprot id: A0A0B4KED7
uniprot id: A0A0B4KEK5
uniprot id: E2QC70
uniprot id: Q9U1I1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

7227:Dmel CG5925
gene id: 7227:Dmel_CG5925
uniprot id: Q9VG68
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG44533
gene id: 7227:Dmel_CG44533
uniprot id: M9NEF7
uniprot id: M9NF40
uniprot id: M9NGD4
uniprot id: Q9VY99
uniprot id: X2JBR4
uniprot id: X2JDN6
uniprot id: X2JK43
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed in larvae and adults.
messages: In larvae, highly expressed in the brain, optic lobes, and ventral ganglia.
messages: Metallocarboxypeptidase.
messages: Mitochondrion
messages: Semilethal phenotype: females survive, while males die. Most male flies die between the late second instar larval stage and early pupal stage. Mutant males that survive to produce pupal cases initiate morphogenesis but die before head eversion. Almost all male flies that survive past head eversion do complete morphogenesis, and then eclose as 'escaper' males. Escapers display a range of phenotypes that mirror the disease pathology observed in pcd mice, including retinal degeneration.

7227:Dmel CG13690
gene id: 7227:Dmel_CG13690
uniprot id: C0MJM8
uniprot id: Q9VPP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

7227:Dmel CG45787
gene id: 7227:Dmel_CG45787
uniprot id: A8QI68
names: Caution
names: Similarity
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG2512
gene id: 7227:Dmel_CG2512
uniprot id: P06605
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

7227:Dmel CG33816
gene id: 7227:Dmel_CG33816
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG8776
gene id: 7227:Dmel_CG8776
uniprot id: A0A0B4LEY2
uniprot id: A0A0B4LF85
uniprot id: E2QCC2
uniprot id: Q0E9A2
uniprot id: Q7JR72
uniprot id: Q95T77
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32191
gene id: 7227:Dmel_CG32191
uniprot id: Q8IQS4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG31911
gene id: 7227:Dmel_CG31911
uniprot id: Q9VMB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7227:Dmel CG17134
gene id: 7227:Dmel_CG17134
uniprot id: Q9VKP6
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG7912
gene id: 7227:Dmel_CG7912
uniprot id: Q9VAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7227:Dmel CG30016
gene id: 7227:Dmel_CG30016
uniprot id: A1Z8C9
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

7227:Dmel CG14690
gene id: 7227:Dmel_CG14690
uniprot id: Q9VGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG4437
gene id: 7227:Dmel_CG4437
uniprot id: Q8SXQ7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Membrane
messages: Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.
messages: Regulated by the imd/Relish pathway.

7227:Dmel CG10021
gene id: 7227:Dmel_CG10021
uniprot id: Q9VQU9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at the termini of the blastoderm embryo in three domains; strongly expressed at the posterior pole, relatively weakly expressed at the anterior pole and expressed in a broad transverse stripe just anterior to the presumptive cephalic furrow. Subsequent to the blastoderm stage, the expression pattern reflects the morphological rearrangements associated with gastrulation. Additionally, at early gastrulation, terminal expression is supplemented by weak expression in seven stripes. These primary stripes are rapidly supplemented by seven secondary stripes. Relatively uniformly expressed throughout the anlagen, primordia and epithelia of the embryonic foregut and hindgut. By stage 13, hindgut expression is greatly reduced but foregut expression remains high until stage 17. Segmentally expressed in the developing leg; present at a subset of segmental boundaries including all proximal joints (coxa/femur, femur/tibia, tibia/t1) and the distal t5/pretarsal boundary.
messages: Nucleus
messages: Putative transcription factor. Required for leg joint formation, acting downstream of Notch to pattern the leg tarsal segments. Functions in the terminal pathway during embryogenesis, acting downstream of tll in the posterior of the embryo. Acts in a hierarchy downstream of drm and lin during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.

7227:Dmel CG44239
gene id: 7227:Dmel_CG44239
uniprot id: Q9V7W1
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Homozygous lethal.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere.
messages: Was originally (PubMed:11102367) named veg. However, more thorough studies (PubMed:22575127) found that the veg phenotype does not map to this protein. It is still not known which gene corresponds to the veg phenotype.

7227:Dmel CG33048
gene id: 7227:Dmel_CG33048
uniprot id: Q8IQF1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.
messages: Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
messages: Isoform Mocs1a and isoform Mocs1b probably form a heterooligomer.
messages: Isoform Mocs1a seems to be translated from a bicistronic transcript while isoform Mocs1b seems to be translated from a monocistronic mRNA that is derived by alternative splicing.
messages: The C-terminus of Mocs1a was previously believed to be thiocarboxylated, but it is now known not to be the case.

7227:Dmel CG33908
gene id: 7227:Dmel_CG33908
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG9657
gene id: 7227:Dmel_CG9657
uniprot id: Q9W3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG4860
gene id: 7227:Dmel_CG4860
uniprot id: Q9VGC2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7227:Dmel CG6207
gene id: 7227:Dmel_CG6207
uniprot id: A4V1U5
uniprot id: M9NE76
uniprot id: Q9VTG7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Expressed from early embryos to adults; maximal expression in third instar larvae through to adulthood.
messages: Golgi apparatus membrane
messages: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
messages: Membrane

7227:Dmel CG8831
gene id: 7227:Dmel_CG8831
uniprot id: Q9V6B9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUP54 family.
messages: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050). Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346).
messages: Component of the nuclear pore complex (PubMed:17682050). Interacts with Nup58 (PubMed:33856346). Interacts (via C-terminus) with fs(1)Yb; this interaction occurs in a RNA-independent manner (PubMed:33856346). Interacts with sbr/nxf1 (PubMed:33856346). Interacts with Nxt1 (PubMed:33856346).
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: nuclear pore complex

7227:Dmel CG5878
gene id: 7227:Dmel_CG5878
uniprot id: Q9VBL5
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

7227:Dmel CG3213
gene id: 7227:Dmel_CG3213
uniprot id: Q9VQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

7227:Dmel CG32120
gene id: 7227:Dmel_CG32120
uniprot id: Q9N658
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Almost exclusively restricted to precursors and early differentiating cells of the embryonic PNS. Expressed in the R8 photoreceptor during third instar eye development beginning within the morphogenetic furrow of the eye imaginal disk.
messages: Mutants abolish the further up-regulation and maintenance of proneural gene expression in the SOPs.
messages: Nucleus
messages: Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.

7227:Dmel CG9398
gene id: 7227:Dmel_CG9398
uniprot id: Q86PC9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TUB family.
messages: Cytoplasm
messages: Detected in sensory neurons which have a ciliary structure such as the chordotonal neurons, Orco-expressing olfactory receptor neurons, labellar gustatory receptor neurons and in the femoral chordotonal organ (at protein level) (PubMed:24068974, PubMed:26723017). In the chordotonal neurons of the Johnston's organ expressed in the proximal to distal cilia, with lower levels of expression in the distal portion (at protein level) (PubMed:24068974). Also detected in the salivary glands and antenna (at protein level) (PubMed:24068974). Expressed in photoreceptor cells (at protein level) (PubMed:23228091). At stage 9 expression is detected in a subset of neuroblasts (PubMed:12204260). By stage 12 expression is found in both the CNS and PNS (PubMed:12204260). In late-stage embryos, expression persists in the CNS and PNS with more abundant expression in the antennal-maxillary sensory neurons and in bilateral groups of cells in the brain (PubMed:12204260).
messages: Functions in regulating protein trafficking, retinal maintenance and lipid storage (PubMed:23228091, PubMed:23355467, PubMed:24068974, PubMed:26723017). Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA-mediated endocytosis of the rhodopsin ninaE (Rh1) (PubMed:23228091). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC (PubMed:24068974, PubMed:26723017). Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base (PubMed:24068974, PubMed:26723017). Plays a role in the inhibition of fat storage (PubMed:23355467).
messages: Most abundant at 2-8 hours of embryonic development.
messages: Nucleus
messages: The C-terminus is important for mediating light-induced rhodopsin endocytosis.
messages: Viable and fertile however flies display a decreased climbing index and extracellular sound-evoked potentials are completely abolished (PubMed:24068974). This hearing defect is likely due to the abnormal localization of the two transient receptor potential channels iav and nompC, as well as eys within the cilia (PubMed:24068974). There is no localization of iav to the proximal cilia, and nompc which is typically found in the distal cilia, is localized to the proximal cilia (PubMed:24068974). Also eys displays a much broader expression pattern (PubMed:24068974). RNAi-mediated knockdown in the fat body of larvae fed a high sugar diet, results in an increase in body weight, an increase in triglyceride accumulation and a decrease in hemolymph glucose levels (PubMed:23355467).
messages: cilium membrane

7227:Dmel CG1607
gene id: 7227:Dmel_CG1607
uniprot id: A0A0B4KHK8
uniprot id: Q9V9Y0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG34192
gene id: 7227:Dmel_CG34192
uniprot id: Q6IG91
names: Similarity
messages: Belongs to the GAMAD family.

7227:Dmel CG6743
gene id: 7227:Dmel_CG6743
uniprot id: Q9V466
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Chromosome
messages: Embryonic lethal (PubMed:18562695, PubMed:26485283). RNAi-mediated knockdown in somatic gonadal cells results in female, but not male, infertility associated with extensive disintegration of the egg chambers and cell death in nurse cells (PubMed:26485283). RNAi-mediated knockdown in spermatocytes causes abnormal localization of nuclear type-B lamin Lam, abnormal spindle envelope integrity and overall defective cytokinesis in meiosis (PubMed:27402967).
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:18562695, PubMed:31626769). Expressed in embryonal and larval neuroblasts (at protein level) (PubMed:18562695). Expressed during oogenesis (at protein level) (PubMed:31626769).
messages: Expressed in spermatocytes (at protein level).
messages: Nucleus envelope
messages: Nucleus matrix
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: Plays a role in nuclear pore complex (NPC) assembly and maintenance (PubMed:20547758). Required for nuclear import of Mad (PubMed:20547758). Mediates the association between the nuclear pore complex and a subset of active chromatin regions adjacent to lamin-associated domains (PubMed:31784359). Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope (PubMed:27402967). Regulates female gonad development and oogenesis (PubMed:26485283).
messages: nuclear pore complex
messages: spindle

7227:Dmel CG5006
gene id: 7227:Dmel_CG5006
uniprot id: P81916
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in the antenna and in a subset of 18 olfactory receptor neurons in the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG10778
gene id: 7227:Dmel_CG10778
uniprot id: Q9W3M6
names: Similarity
messages: Belongs to the UPP synthase family.

7227:Dmel CG14149
gene id: 7227:Dmel_CG14149
uniprot id: Q9VTC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted, Pldn and Snapin. Interacts with Pldn.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.

7227:Dmel CG12225
gene id: 7227:Dmel_CG12225
uniprot id: N0D8I3
uniprot id: Q9W420
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Self associates. Interacts with RNA polymerase II. Interacts with the FACT complex, which is composed of dre4/Spt16 and Ssrp/Ssrp1. Interacts with the exosome, a complex with 3'-5' exoribonuclease activity which is composed of at least Csl4, Dis3, Mtr3, Rrp4, Rrp6, Rrp40, Rrp42, Rrp46 and Ski6. Interacts with the DRB sensitivity-inducing factor complex (the DSIF complex), which is composed of Spt4 and Spt5.
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).
messages: Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle.

7227:Dmel CG7393
gene id: 7227:Dmel_CG7393
uniprot id: O61443
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation by Mkk3.
messages: At mid-embryogenesis, highest expression is seen in developing anterior and posterior midguts. Almost ubiquitous expression throughout all development.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
messages: Expressed both maternally and zygotically in the embryo, expression seen in all developmental stages.
messages: Kinase involved in dpp signal transduction pathway in the process of wing morphogenesis when the levels of dpp are enhanced or inhibited. May down-regulate insect immunity gene expression after prolonged infection.
messages: Nucleus
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

7227:Dmel CG6455
gene id: 7227:Dmel_CG6455
uniprot id: A0A0B4KGN2
uniprot id: A0A0B4KHL7
uniprot id: P91928
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity).
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (By similarity). Interacts with the mitochondria-shaping protein Opa1 (PubMed:24998521).
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7227:Dmel CG8277
gene id: 7227:Dmel_CG8277
uniprot id: Q9VSB6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7227:Dmel CG11579
gene id: 7227:Dmel_CG11579
uniprot id: M9PGG4
uniprot id: P18824
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-catenin family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with Mer and Moe at the adherens junction (PubMed:8666669). Interacts with Inx2 (PubMed:15047872). Interacts with alpha-Cat (PubMed:25653389). Interacts with Myo31DF (PubMed:16598259, PubMed:22491943).
messages: Isoform cytoplasmic accumulates at low levels in axons, at high levels in specific cells along the CNS midline and in leg and eye imaginal disks. Isoform neural accumulates in the axon tracts of the CNS. Both isoforms accumulate in the peripheral nervous system.
messages: Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis.
messages: Membrane
messages: Phosphorylated on Ser, Thr and Tyr residues (PubMed:7529201). Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue (PubMed:7529201). Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation (PubMed:7529201). Hypophosphorylated form of arm increases in steady-state levels (PubMed:7529201). Phosphorylated directly or indirectly by CkIalpha which stimulates its degradation (PubMed:11927557).
messages: Present at all stages, but reaches the highest levels during early to mid-embryogenesis. Isoform cytoplasmic is the predominant one from the cellular blastoderm stage until germ-band retraction. Isoform neural is first seen after germ band retraction.
messages: adherens junction

7227:Dmel CG8399
gene id: 7227:Dmel_CG8399
uniprot id: A0A0B4LGL5
uniprot id: Q8MSU3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
messages: The cytochrome b561 domain lacks the conserved His residue that binds iron in the heme. The reductase activity is therefore unsure in vivo.

7227:Dmel CG3158
gene id: 7227:Dmel_CG3158
uniprot id: L0CR04
uniprot id: Q9VF26
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Egg chambers for females lacking spn-E display startmispositioned oocytes. At a low frequency, females generate early egg chambers in which the oocyte is positioned incorrectly within the cyst. At a high frequency, late-stage egg chambers exhibit a ventralized chorion. Flies show transposable elements derepression, an aberrant piRNA profile and a reduction of H3 'Lys-9' methylation and delocalization of HP1 and HP2.
messages: Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis.

7227:Dmel CG7943
gene id: 7227:Dmel_CG7943
uniprot id: Q7K483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG7897
gene id: 7227:Dmel_CG7897
uniprot id: A1Z6H7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NUP210 family.
messages: Component of the nuclear pore complex.
messages: Cytoplasm
messages: Expressed in adult male accessory glands (at protein level).
messages: Expressed in embryos and third instar larvae (at protein level) (PubMed:3919018, PubMed:2517292, PubMed:7641726). Levels are highest during embryogenesis, decrease through larval stages, and finally increase during pupation and adult stages (PubMed:7641726).
messages: Glycosylated.
messages: Nucleus membrane
messages: nuclear pore complex

7227:Dmel CG6269
gene id: 7227:Dmel_CG6269
uniprot id: O77215
uniprot id: X2JCE2
uniprot id: X2JFX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Unc-4 subfamily.
messages: During embryonic and third instar larval stages, expressed in subsets of postmitotic neurons in the central nervous system (CNS) and in the developing epidermis with a segmentally repeated pattern.
messages: Nucleus
messages: Transcription factor that regulates synaptic specificity.

7227:Dmel CG9388
gene id: 7227:Dmel_CG9388
uniprot id: O62531
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

7227:Dmel CG2872
gene id: 7227:Dmel_CG2872
uniprot id: Q9U721
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7227:Dmel CG14620
gene id: 7227:Dmel_CG14620
uniprot id: Q9VR52
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tilB family.
messages: Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella.
messages: Cytoplasm
messages: Expressed in chordotonal sense organs, Johnston's organ and sperm (at protein level). Expressed in ciliated cells. Expressed in the head and testis.
messages: Expressed in ciliated cells of the chordotonal organs, neurons of Johnston's organ and femoral chordotonal organs, olfactory sensilla on the antenna in late stage embryos and larvae.
messages: Larvae mutants are insensitive to touch and have defects in larval locomotion. Adult mutants show defects in motility and coordination and are deaf; lack antenna oscillations and mechanical amplification of stimulus-induced antennal vibrations. Mutant males can mate but are sterile because of amotile sperm; tail axonemes lacked the inner dynein arms.
messages: dendrite
messages: flagellum

7227:Dmel CG9881
gene id: 7227:Dmel_CG9881
uniprot id: Q9VQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: cytoskeleton

7227:Dmel CG7957
gene id: 7227:Dmel_CG7957
uniprot id: Q9VEC1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Chromosome
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. Negatively regulates sex comb development.
messages: Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31. Interacts with Hsf.
messages: Maternally encoded. Expression decreases during larval stages then rises during mid-pupal metamorphosis.
messages: Nucleus

7227:Dmel CG18743
gene id: 7227:Dmel_CG18743
uniprot id: P02825
uniprot id: P82910
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Forms a complex with Hsp83 and Dpit47.
messages: Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
messages: There are two copies of the gene coding for this protein at chromosome locus 87A7.

7227:Dmel CG34367
gene id: 7227:Dmel_CG34367
uniprot id: A2RVG7
uniprot id: A8DYR8
uniprot id: M9PCS1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7537
gene id: 7227:Dmel_CG7537
uniprot id: Q9VWL5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed in the cortex of the pupal CNS and at low levels in the wing imaginal disk.
messages: Little or no embryonic expression.
messages: Structural component of the gap junctions.
messages: gap junction

7227:Dmel CG10083
gene id: 7227:Dmel_CG10083
uniprot id: Q9VU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin (By similarity). Does not seem to be involved in actin-based lamella protrusion during cell migration.
messages: Belongs to the ABP1 family.
messages: cytoskeleton

7227:Dmel CG13495
gene id: 7227:Dmel_CG13495
uniprot id: Q9W2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons, labral sense organ and thorax. In larvae, is in neurons of the terminal external chemosensory organ as well as in the dorsal pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG31929
gene id: 7227:Dmel_CG31929
uniprot id: P58952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Taste bristles in the foreleg and labial palps.

7227:Dmel CG10498
gene id: 7227:Dmel_CG10498
uniprot id: E1JIR3
uniprot id: P23573
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Interacts with cyclin CycG.
messages: Like Cdk1, could play a key role in the control of the eukaryotic cell cycle.

7227:Dmel CG15669
gene id: 7227:Dmel_CG15669
uniprot id: Q7KVN1
uniprot id: Q8IGI1
uniprot id: Q8IRK7
uniprot id: Q8T0V2
uniprot id: Q9GU50
uniprot id: Q9I7V6
uniprot id: Q9I7V7
names: Similarity
messages: Belongs to the NDRG family.

7227:Dmel CG8545
gene id: 7227:Dmel_CG8545
uniprot id: A1Z909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

7227:Dmel CG14206
gene id: 7227:Dmel_CG14206
uniprot id: M9NEQ9
uniprot id: Q9VWG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Cytoplasm

7227:Dmel CG5796
gene id: 7227:Dmel_CG5796
uniprot id: Q9VC52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

7227:Dmel CG6981
gene id: 7227:Dmel_CG6981
uniprot id: Q9VW87
names: Developmental Stage
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
messages: Apicolateral cell membrane
messages: Detected from embryonic stage 12 onwards in midgut and Malpighian tubules (at protein level) (PubMed:22328496, PubMed:22854041, PubMed:26848177). Also detected in the outer epithelial layer of the proventriculus in first instar larvae (at protein level) (PubMed:22854041).
messages: Forms a complex with Tsp2A and mesh (PubMed:26848177). Interacts with mesh; the interaction may be necessary for the localization of both proteins to the cell apicolateral region (PubMed:22854041).
messages: Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A (PubMed:22854041, PubMed:26848177). May be important for barrier function of the midgut epithelium.
messages: Unlikely isoform.
messages: septate junction

7227:Dmel CG10424
gene id: 7227:Dmel_CG10424
uniprot id: Q9VVW8
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

7227:Dmel CG4830
gene id: 7227:Dmel_CG4830
uniprot id: Q9VGC5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG8663
gene id: 7227:Dmel_CG8663
uniprot id: M9PDX8
uniprot id: Q7JS69
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

7227:Dmel CG12891
gene id: 7227:Dmel_CG12891
uniprot id: Q7JQH9
uniprot id: Q9V3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG9842
gene id: 7227:Dmel_CG9842
uniprot id: M9NE01
uniprot id: Q27889
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
messages: Expressed both maternally and zygotically in embryos, larvae and adults.
messages: Expressed in CNS and PNS.
messages: Interacts with sra in a complex that contains CanA-14F.

7227:Dmel CG5008
gene id: 7227:Dmel_CG5008
uniprot id: Q9NHA8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect beta-1,3-glucan binding protein family.
messages: Expressed at very low levels during embryonic development. Expression increases during the larva stages and peaks at a moderate level during the late larval, prepupal and pupal stages, before decreasing in the adult.
messages: Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).
messages: Secreted

7227:Dmel CG12233
gene id: 7227:Dmel_CG12233
uniprot id: Q9VWH4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
messages: Mitochondrion

7227:Dmel CG10523
gene id: 7227:Dmel_CG10523
uniprot id: Q7KTX7
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auto-ubiquitinates in an E2-dependent manner leading to its own degradation.
messages: Belongs to the RBR family. Parkin subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as Paris, Marf, Opa1, Miro, pnut, Septin1, Tom20 and porin (PubMed:16002472, PubMed:17456438, PubMed:25474007, PubMed:20194754, PubMed:24192653, PubMed:24901221, PubMed:27906179, PubMed:31714929, PubMed:32138754, PubMed:32047033, PubMed:23770917). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates, depending on the context (PubMed:18957282, PubMed:24901221, PubMed:25474007, PubMed:23650379, PubMed:27906179, PubMed:31714929, PubMed:32047033). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of Pink1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:12642658, PubMed:15073152, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18957282, PubMed:18799731, PubMed:18230723, PubMed:18443288, PubMed:20496123, PubMed:20194754, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:12642658, PubMed:15073152, PubMed:16002472, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18957282, PubMed:18799731, PubMed:18230723, PubMed:18443288, PubMed:20496123, PubMed:20194754, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033). Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including sperma…
messages: Expressed throughout development (PubMed:14646593, PubMed:12642658, PubMed:16002472, PubMed:15073152). Highest levels of expression in adults and early embryos (PubMed:15073152, PubMed:14646593). First detected in 0-2 hour embryos, likely due to a maternal contribution as it is not detected during the rest of embryogenesis (PubMed:15073152). Expressed in third instar larvae, throughout pupal development and in adults (PubMed:15073152).
messages: Forms an E3 ubiquitin ligase complex with E2 ubiquitin-conjugating enzymes (PubMed:17456438). Interacts with Pink1 (PubMed:19048081). Interacts with Marf (PubMed:24898855, PubMed:20194754). Interacts with Paris (PubMed:32138754). Interacts with septins Septin1 and pnut (PubMed:17456438).
messages: In oocytes, accumulates in early egg chambers where it is enriched until stages 9-10, localizing mainly to the posterior pole and anterior margin (at protein level) (PubMed:20869429). After stage 10 it is no longer detected in the oocyte (at protein level) (PubMed:20869429). In embryos, ubiquitously expressed in the early stages (stages 2 to 5) (at protein level) (PubMed:14646593). Expression levels decrease at later stages and becomes restricted to the brain and nerve cord from stage 9 (at protein level) (PubMed:14646593). Relatively higher levels of expression in the head compared to the body (PubMed:16002472). Enriched in the dorsomedial (DM) dopaminergic neurons (PubMed:16002472).
messages: In the autoinhibited state the side chain of Phe-481 inserts into a hydrophobic groove in RING-0, occluding the ubiquitin acceptor site Cys-449, whereas the REP repressor element binds RING-1 and blocks its E2-binding site (By similarity). Activation of park requires 2 steps: (1) phosphorylation at Ser-94 by Pink1 and (2) binding to phosphorylated ubiquitin, leading to unlock repression of the catalytic Cys-449 by the RING-0 region via an allosteric mechanism and converting park to its fully-active form (PubMed:25474007, PubMed:18957282, PubMed:20194754, PubMed:24901221, PubMed:27906179). According to another report, phosphorylation at Ser-94 by Pink1 is not essential for activation and only binding to phosphorylated ubiquitin is essential to unlock repression (By similarity).
messages: Members of the RBR family are atypical E3 ligases (PubMed:17456438, PubMed:23770917). They interact with E2 conjugating enzymes and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain (PubMed:17456438, PubMed:23770917).
messages: Mitochondrion
messages: Phosphorylated (PubMed:18957282, PubMed:24901221, PubMed:25474007, PubMed:27906179). Activation requires phosphorylation at Ser-94 by Pink1 and binding to Pink1-phosphorylated polyubiquitin chains (PubMed:18957282, PubMed:24901221, PubMed:25474007, PubMed:27906179). Phosphorylation at Thr-187 by Pink1 is also important for mitochondrial localization (PubMed:18957282).
messages: Pupal lethal; large percentage fail to enclose (PubMed:15073152). Escapers that develop into adults display various phenotypes that appear to be the result of mitochondrial abnormalities and/or mitochondrial dysfunction (PubMed:16672980, PubMed:24192653, PubMed:23509287, PubMed:29497364). In various tissues including the indirect flight muscles (IFM), thoracic muscles, sperm, cardiomyocytes and neurons such as the dopaminergic (DA) neurons, mitochondria display abnormalities such as swelling, loss of cristae, fragmentation, aggregation and/or mitochondrial disorganization, and they are dysfunctional resulting in defects such as mitochondrial depolarization, increased reactive oxygen species (ROS) production, reduced ATP, decreased mitochondrial DNA and reduced mitochondrial protein levels (PubMed:15073152, PubMed:17123504, PubMed:18957282, PubMed:18799731, PubMed:20483372, PubMed:24192653, PubMed:24901221, PubMed:29497364). As a result adults are reduced in size, display reduced survival and decreased fertility (PubMed:15073152, PubMed:16672980, PubMed:17123504, PubMed:24192653, PubMed:24901221, PubMed:29497364). They also exhibit age-dependent and progressive degradation of the IFM and the DA neurons, especially in the protocerebral posterior lateral 1 (PPL1) cluster, which likely contribute to the observed locomotive defects, down-turned rigid wings and crushed thorax phenotypes (PubMed:15073152, PubMed:16002472, PubMed:18957282, PubMed:18799731, PubMed:24901221, PubMed:29497364). However, another report did not observe any age-dependent dopaminergic neuron loss within 21 days post-eclosion (PubMed:15073152). Also affects non-motor behaviors such as reduced three-hour memory performance and irregular circadian rhythms under constant darkness, likely as a result of the neurodegradation (PubMed:28435104). Double knockout of Pink1 and park display no increase in the severity of their phenotypes compared to single mutants (PubMed:16672980). However, expression of park…
messages: The RING-type 1 zinc finger domain is required for ubiquitination activity.
messages: cytosol

7227:Dmel CG33836
gene id: 7227:Dmel_CG33836
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG6251
gene id: 7227:Dmel_CG6251
uniprot id: Q7JXF5
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nucleoporin NSP1/NUP62 family.
messages: Chromosome
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes (PubMed:20144760). Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556).
messages: Expressed in adult male accessory glands (at protein level).
messages: Nucleus
messages: Nucleus envelope
messages: RNAi-mediated knockdown in oocytes results in increased nuclear size. RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery disrupting karyosome morphology. Simultaneous RNAi-mediated knockdown of nucleoporin Nup154 restores normal karyosome formation.
messages: centrosome
messages: nuclear pore complex
messages: spindle pole

7227:Dmel CG4491
gene id: 7227:Dmel_CG4491
uniprot id: Q24423
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the Elbow/Noc family.
messages: Expressed from stage 4 in the embryonic termini and at stage 5/6 in the ectodermal stripes. Expressed in the invaginating tracheal pits at stage 11, and ubiquitously throughout the embryo from stage 13. Expressed in the highly proliferative region of the eye-head primordium. Expressed in the distal regions of leg and wing imaginal discs. Expressed predominantly in embryo and pupae.
messages: Highly expressed in the adult head.
messages: Interacts with elB.
messages: May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development.

7227:Dmel CG31014
gene id: 7227:Dmel_CG31014
uniprot id: Q9VA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG1895
gene id: 7227:Dmel_CG1895
uniprot id: M9PEC6
uniprot id: Q9VYT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG1830
gene id: 7227:Dmel_CG1830
uniprot id: Q961E7
uniprot id: Q9I7D0
uniprot id: X2JEJ4
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

7227:Dmel CG9883
gene id: 7227:Dmel_CG9883
uniprot id: Q9VQD6
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed throughout much embryogenesis. Expression peaks at the blastoderm stage (2-4 hours) and at later embryonic stages expression corresponds mostly to the procephalic ectoderm primordium.
messages: Nucleus
messages: The BEN domain mediates DNA-binding.
messages: The heterotrimeric Elba complex consists of Elba1, Elba2 and Elba3.
messages: The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity (PubMed:23240086). Elba2 can act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495).

7227:Dmel CG6070
gene id: 7227:Dmel_CG6070
uniprot id: Q9VB75
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6315
gene id: 7227:Dmel_CG6315
uniprot id: A0A0B4K713
uniprot id: Q9Y091
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:1695150, PubMed:27919077). M6A methylation is also required for neuronal functions (PubMed:27919077). Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174).
messages: Belongs to the fl(2)d family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755). Interacts with vir and msk (PubMed:12444081). Part of a complex containing fl(2)d, Sxl and vir (PubMed:12444081).
messages: Major.
messages: Minor.
messages: Nucleus
messages: Ubiquitously expressed in early embryonic stages with enrichment in the neuroectoderm at later stages.

7227:Dmel CG5323
gene id: 7227:Dmel_CG5323
uniprot id: Q7JVK8
names: Similarity
messages: Belongs to the FAM136 family.

7227:Dmel CG7069
gene id: 7227:Dmel_CG7069
uniprot id: Q9VD23
names: Similarity
messages: Belongs to the pyruvate kinase family.

7227:Dmel CG7398
gene id: 7227:Dmel_CG7398
uniprot id: Q9VRV8
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG3400
gene id: 7227:Dmel_CG3400
uniprot id: Q0KHQ6
uniprot id: Q9VWH7
uniprot id: X2JED9
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

7227:Dmel CG8427
gene id: 7227:Dmel_CG8427
uniprot id: A0A1B2AJH4
uniprot id: O44437
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Interacts with the SMN complex.
messages: Methylated on arginine residues by Art5 and Art7; methylation is not required for assembly and biogenesis of snRNPs.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

7227:Dmel CG7411
gene id: 7227:Dmel_CG7411
uniprot id: Q9VDU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG5026
gene id: 7227:Dmel_CG5026
uniprot id: Q8SZY7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7227:Dmel CG40733
gene id: 7227:Dmel_CG40733
uniprot id: G5CKU5
names: Function
names: Subcellular Location Annotation
messages: Neuropeptides RYamide-1 and RYamide-2 are ligands for the G-protein coupled receptor RYa-R (PubMed:21843505, PubMed:21704020). May suppress feeding behavior (PubMed:21704020).
messages: Secreted

7227:Dmel CG17287
gene id: 7227:Dmel_CG17287
uniprot id: A1ZAR2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG6607
gene id: 7227:Dmel_CG6607
uniprot id: Q9VC66
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

7227:Dmel CG8093
gene id: 7227:Dmel_CG8093
uniprot id: Q4V6L4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG8483
gene id: 7227:Dmel_CG8483
uniprot id: Q9VFY2
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG8808
gene id: 7227:Dmel_CG8808
uniprot id: A0A0B4K7V5
uniprot id: A0A0B4KFG2
uniprot id: A8DY78
uniprot id: P91622
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Expressed both maternally and zygotically.
messages: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
messages: Mitochondrion matrix

7227:Dmel CG32500
gene id: 7227:Dmel_CG32500
uniprot id: Q8SY96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion
messages: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.

7227:Dmel CG11755
gene id: 7227:Dmel_CG11755
uniprot id: A0A0B4KFI0
uniprot id: Q9VHN3
names: Similarity
messages: Belongs to the CDPF1 family.

7227:Dmel CG12792
gene id: 7227:Dmel_CG12792
uniprot id: Q8SYL1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG9522
gene id: 7227:Dmel_CG9522
uniprot id: Q9VY11
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG11155
gene id: 7227:Dmel_CG11155
uniprot id: Q8IM95
uniprot id: Q9V4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG17818
gene id: 7227:Dmel_CG17818
uniprot id: Q9U9P7
names: Function
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.
messages: Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity.

7227:Dmel CG7660
gene id: 7227:Dmel_CG7660
uniprot id: Q9VEG6
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per heterodimer.
messages: Expressed at low levels in the germarium and early follicles. Expression becomes progressively stronger during vitellogenesis, and is highly expressed in germ cells and somatic cells. A subset of follicle cells, termed border cells (BC), exhibit a high level of expression.
messages: Expressed both maternally and zygotically.
messages: Females are sterile, and maturing follicles show defects in actin filament formation, nurse cell membrane stability and border cell migration.
messages: Heterodimer.
messages: Required for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.
messages: Secreted

7227:Dmel CG3534
gene id: 7227:Dmel_CG3534
uniprot id: Q9VEQ0
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

7227:Dmel CG17950
gene id: 7227:Dmel_CG17950
uniprot id: Q05783
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.
messages: Chromosome
messages: Nucleus
messages: Present in all stages of development.

7227:Dmel CG6262
gene id: 7227:Dmel_CG6262
uniprot id: A1ZAE9
uniprot id: A1ZAF2
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

7227:Dmel CG33849
gene id: 7227:Dmel_CG33849
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG12531
gene id: 7227:Dmel_CG12531
uniprot id: M9PHM0
uniprot id: Q9VWD3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5619
gene id: 7227:Dmel_CG5619
uniprot id: Q24155
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the noggin family.
messages: Required for activity of the tor receptor, could be a ligand of tor. Involved in specifying terminal body pattern.
messages: Secreted

7227:Dmel CG11851
gene id: 7227:Dmel_CG11851
uniprot id: Q9VBV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG7081
gene id: 7227:Dmel_CG7081
uniprot id: Q9VSH8
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

7227:Dmel CG12268
gene id: 7227:Dmel_CG12268
uniprot id: Q9VCF6
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG8822
gene id: 7227:Dmel_CG8822
uniprot id: Q9VQL9
names: Similarity
messages: Belongs to the PPP phosphatase family.

7227:Dmel CG9503
gene id: 7227:Dmel_CG9503
uniprot id: Q9VY00
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG9463
gene id: 7227:Dmel_CG9463
uniprot id: Q9VLI2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG14084
gene id: 7227:Dmel_CG14084
uniprot id: Q9VVX6
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG15302
gene id: 7227:Dmel_CG15302
uniprot id: Q9W2U9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG7187
gene id: 7227:Dmel_CG7187
uniprot id: A0A0B4KGW6
uniprot id: Q9VEB9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG9191
gene id: 7227:Dmel_CG9191
uniprot id: P46863
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Cytoplasm
messages: Homotetramer (PubMed:8538794, PubMed:9885249, PubMed:24714498). Consists of two pairs of polypeptides associated by coiled-coil interactions to form two homodimers (PubMed:8538794). The homodimers are linked by lateral interactions between their coiled-coil regions to form a bipolar homotetramer consisting of a central rod with two motor domains projecting from either end (PubMed:8538794). Parallel coiled coils extend from each pair of motor heads, switch to two antiparallel coiled coils in the central region and then back to parallel coiled coils (PubMed:24714498). Interacts with Wee1 (PubMed:19800237).
messages: Important role in mitotic dividing cells (PubMed:8227131). Microtubule motor required for spindle body separation (PubMed:8918872). Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function (PubMed:8918872, PubMed:8589456, PubMed:19062285). Forms cross-links between microtubules within interpolar microtubule bundles (PubMed:9885249, PubMed:19158379). Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinetochore spacing, and anaphase A rates (PubMed:19158379). Displays microtubule-stimulated ATPase activity (PubMed:8589456). Required for normal fusome organization (PubMed:10469596). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
messages: Phosphorylation is required for localization to mitotic spindles (PubMed:9885249). Phosphorylation of Thr-933 during mitosis controls association with the spindle apparatus (By similarity). Phosphorylated in vitro by Wee1 (PubMed:19800237).
messages: Specifically expressed in proliferating tissues during embryonic and larval development.
messages: spindle
messages: spindle pole

7227:Dmel CG10289
gene id: 7227:Dmel_CG10289
uniprot id: M9PEB1
uniprot id: M9PEH8
uniprot id: Q9VRV1
names: Similarity
messages: Belongs to the SAPS family.

7227:Dmel CG13997
gene id: 7227:Dmel_CG13997
uniprot id: Q9VMK5
names: Function
messages: Major early eggshell protein.

7227:Dmel CG5906
gene id: 7227:Dmel_CG5906
uniprot id: Q9VTQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG5102
gene id: 7227:Dmel_CG5102
uniprot id: P11420
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Daughterless/Achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
messages: Homodimer. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with Amos. Interacts (via bHLH motif) with sisA and sc. Interacts with dpn (via bHLH motif).
messages: Nucleus
messages: Ubiquitous.

7227:Dmel CG3238
gene id: 7227:Dmel_CG3238
uniprot id: Q9VQR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

7227:Dmel CG13775
gene id: 7227:Dmel_CG13775
uniprot id: Q9VM61
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG6582
gene id: 7227:Dmel_CG6582
uniprot id: Q9V431
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis.
messages: Belongs to the API5 family.
messages: Enhanced E2f1-induced apoptosis.
messages: Nucleus

7227:Dmel CG33133
gene id: 7227:Dmel_CG33133
uniprot id: Q9U405
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: Homodimer; at the zf-AD.
messages: Nucleus
messages: Present throughout embryogenesis, in larvae, in ovaries and other tissues of adult females, and in adult males. In ovaries, it is expressed in both follicle cells and nurse cells. Expressed from stage 9 in the germarium. Weakly or not expressed in the oocyte nucleus.
messages: The N-terminal zf-AD is an atypical treble-clef like zinc binding domain which enables dimerization, and appears not to have any DNA-binding ability. DNA binding is achieved through the zinc fingers at the C-terminus.
messages: Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.

7227:Dmel CG14998
gene id: 7227:Dmel_CG14998
uniprot id: A8JNK1
uniprot id: F2FB68
uniprot id: M9PBN6
uniprot id: M9PE93
uniprot id: M9PEK8
uniprot id: M9PHB1
uniprot id: Q8IRB9
uniprot id: Q8IRC0
uniprot id: Q8IRC1
uniprot id: Q9I7T2
uniprot id: Q9VZI0
names: Similarity
messages: Belongs to the MAP7 family.

7227:Dmel CG2671
gene id: 7227:Dmel_CG2671
uniprot id: M9NCX1
uniprot id: M9PBJ2
uniprot id: P08111
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat L(2)GL family.
messages: Cytoplasm
messages: Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk.
messages: Expressed abundantly in early embryogenesis. Moderate expression is found in larval and adult stages.
messages: Expressed in the epithelial cells of the digestive tract and in gonads.
messages: Has an accessory function in control of cell proliferation and differentiation during development.
messages: Has an essential role in control of cell proliferation and differentiation during development and could act as a tumor suppressor.
messages: May form multimeric complexes. Interacts with mahj. Interacts with aPKC; leading to phosphorylation (PubMed:18094021, PubMed:20644714). Interacts with ball (PubMed:31735666).
messages: Phosphorylated by aPKC which lowers lipid affinity and promotes dissociation from the cell cortex (PubMed:26481050). In developing oocytes, aPKC-mediated phosphorylation restricts activity to the oocyte posterior and is required for oocyte polarity formation (PubMed:18094021, PubMed:18327897).
messages: The phospho-regulated basic and hydrophobic (PRBH) motif is necessary and sufficient for interaction with phospholipids permitting cortical localization (PubMed:26481050). Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane (PubMed:26481050).
messages: cell cortex

7227:Dmel CG1732
gene id: 7227:Dmel_CG1732
uniprot id: Q8IMC1
uniprot id: Q9V4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG18661
gene id: 7227:Dmel_CG18661
uniprot id: M9MRG1
uniprot id: Q9VLF6
names: Similarity
messages: Belongs to the UPF0585 family.

7227:Dmel CG11124
gene id: 7227:Dmel_CG11124
uniprot id: Q6XPX3
uniprot id: Q8SZB2
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG12983
gene id: 7227:Dmel_CG12983
uniprot id: B7Z092
uniprot id: B7Z093
uniprot id: B7Z094
uniprot id: M9NDE2
uniprot id: M9PID5
names: Similarity
messages: Belongs to the DNAI7 family.

7227:Dmel CG7103
gene id: 7227:Dmel_CG7103
uniprot id: Q9BLX1
uniprot id: Q9VWP6
uniprot id: X2JCH3
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7227:Dmel CG7383
gene id: 7227:Dmel_CG7383
uniprot id: M9PIJ7
uniprot id: P15370
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: During embryonic stages 10 and 11, expression was observed in four neuroblasts, NB2-4, NB3-3, NB6-4 and NB7-3. Except for NB6-4, expression reaches a maximum at the very beginning of expression or in the period of neuroblast delamination. Weak expression is also observed in a few putative progeny of NB7-3 during late embryonic stage 11 and 12. All eagle expression in abdominal segments disappears by stage 13.
messages: EG cells fail to acquire the neural fate or underwent an extremely delayed differentiation, while EW neurons produced neurites in abnormal directions.
messages: May play a critical role in development of the progeny of eagle-positive neuroblasts.
messages: Nucleus

7227:Dmel CG7158
gene id: 7227:Dmel_CG7158
uniprot id: Q9VNZ8
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Deterioration of locomotion in adults with climbing ability strongly depressed.
messages: Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab5 into its active GTP-bound form.
messages: In the embryo, expressed in a wide range of tissues including the epidermis and the ventral nerve cord.

7227:Dmel CG4262
gene id: 7227:Dmel_CG4262
uniprot id: M9NFP7
uniprot id: P16914
names: Function
names: Similarity
messages: Belongs to the RRM elav family.
messages: Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism.

7227:Dmel CG9850
gene id: 7227:Dmel_CG9850
uniprot id: A0A0B4KFG8
uniprot id: A0A0B4KGD6
uniprot id: B7YZP6
uniprot id: Q2MGN5
uniprot id: Q9W1J9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG4747
gene id: 7227:Dmel_CG4747
uniprot id: M9MRG2
uniprot id: Q8T079
uniprot id: X2JDP6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Binds to mononucleosomes (PubMed:29759984). Interacts with male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3 (PubMed:23295261).
messages: Chromosome
messages: In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
messages: Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation and colocalizes with a subset of trimethylated 'Lys-36' histone H3 (H3K36me3)-enriched regions (PubMed:23295261, PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Facilitates male-specific lethal (MSL) histone acetyltransferase complex targeting to active genes on the X chromosome (PubMed:23295261). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by nej (PubMed:29759984). May have oxidoreductase activity (By similarity).
messages: RNAi-mediated knockdown results in ectopic MSL-binding sites on autosomes of male larvae.
messages: The PWWP domain is a H3 reader and strongly binds DNA.

7227:Dmel CG14788
gene id: 7227:Dmel_CG14788
uniprot id: Q9W590
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.
messages: Cytoplasm
messages: Expressed in larval serotonergic neurons.
messages: GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: Larvae reach less than 60% of normal size and have fewer and smaller cells, the adults that survive exhibit normal body proportions and are healthy. In the brains excess serotonin and insulin accumulate, while peripheral insulin pathway activation is low.

7227:Dmel CG11590
gene id: 7227:Dmel_CG11590
uniprot id: Q9VY55
names: Similarity
messages: Belongs to the CutA family.

7227:Dmel CG11881
gene id: 7227:Dmel_CG11881
uniprot id: Q9VAP2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules (PubMed:19836241).
messages: Belongs to the HAUS6 family.
messages: Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:18443220, PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules (PubMed:18443220). dgt6 interacts with CENP-meta, gamma-tubulin, msps, Ndc80, Nuf2 and tacc (PubMed:19836241).
messages: The name 'dim gamma-tubulin 6' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt6 in S2 cells.
messages: centromere
messages: centrosome
messages: kinetochore
messages: spindle
messages: spindle pole

7227:Dmel CG3441
gene id: 7227:Dmel_CG3441
uniprot id: Q9W0W6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the receptor-type guanylate cyclase Gyc76C (PubMed:21893139). Stimulates Gyc76c-dependent cGMP production and modulates the IMD innate immune pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Does not appear to play a role in Gyc76C-mediated wing development (PubMed:26440503).
messages: MTYamide peptide: Expressed in the larval CNS (at protein level). NAP peptide: Expressed in the larval CNS (at protein level). IPNamide peptide: Expressed in the ventral ganglion of the third larval instar and adult brain (at protein level).
messages: Occasional ectopic branching from the posterior crossvein.
messages: Secreted

7227:Dmel CG32813
gene id: 7227:Dmel_CG32813
uniprot id: Q9W599
uniprot id: Q9W5A0
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG13185
gene id: 7227:Dmel_CG13185
uniprot id: A8DYB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

7227:Dmel CG45074
gene id: 7227:Dmel_CG45074
uniprot id: P08155
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Beta isoform is expressed during embryogenesis, most abundant in midembryogenesis, and in adults. Alpha isoform is expressed from embryogenesis to 8 hours after pupariation, major period of expression is during second instar.
messages: Plays a general role in the hierarchies of gene expression leading to metamorphosis.

7227:Dmel CG12743
gene id: 7227:Dmel_CG12743
uniprot id: P10383
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Essential for female fertility; germ cell division and differentiation.
messages: Expressed in both oocyte and nurse cells of the germarium.
messages: Expression is cooperatively activated by Ovo and Stil.

7227:Dmel CG4091
gene id: 7227:Dmel_CG4091
uniprot id: Q7KVH9
names: Similarity
messages: Belongs to the TNFAIP8 family.

7227:Dmel CG6449
gene id: 7227:Dmel_CG6449
uniprot id: Q8MPP0
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ninjurin family.
messages: Cell membrane
messages: Cleaved by Mmp1 protease to generate the Secreted ninjurin-A form.
messages: Homooligomer.
messages: Homophilic transmembrane adhesion molecule involved in non-apoptotic necrotic cell death (PubMed:23028562). Promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity). Probably involved in non-apoptotic necrotic cell death by mediating plasma membrane rupture (cytolysis), leading to release intracellular molecules that propagate the inflammatory response (PubMed:33472215).
messages: No visible phenotype; flies are viable and fertile with no obvious developmental abnormalities.
messages: Secreted
messages: Secreted form generated by cleavage, which acts as a negative regulator of cell adhesion (PubMed:16815999). Promotes the loss of cell adhesion in a cell non-autonomous manner (PubMed:16815999).
messages: Up-regulated upon injury.

7227:Dmel CG9526
gene id: 7227:Dmel_CG9526
uniprot id: Q9VMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Highest activity with lysophosphatidylinositol (1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) or LPI) producing phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) or PI) (LPIAT activity), but also converts lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) producing phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Has a preference for unsaturated fatty acid arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature.
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

7227:Dmel CG3835
gene id: 7227:Dmel_CG3835
uniprot id: Q7K511
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG9450
gene id: 7227:Dmel_CG9450
uniprot id: P25823
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed throughout the life cycle.
messages: Interacts with vls (PubMed:15800004). Interacts with me31B (when dimethylated on Arg residues) (PubMed:28945271).
messages: Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation.
messages: The TUD mRNA accumulates within the posterior region of the developing oocyte during the early to middle stages of oogenesis.

7227:Dmel CG8732
gene id: 7227:Dmel_CG8732
uniprot id: A0A0B4KFE4
uniprot id: A1Z7H2
uniprot id: A1Z7H3
uniprot id: Q8T3L1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG6121
gene id: 7227:Dmel_CG6121
uniprot id: M9PGN1
uniprot id: M9PH08
uniprot id: Q960X4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-355 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV.
messages: Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.
messages: Nucleus

7227:Dmel CG30345
gene id: 7227:Dmel_CG30345
uniprot id: Q1EC10
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG14886
gene id: 7227:Dmel_CG14886
uniprot id: Q9VEU5
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in embryos in a segmental pattern in the ventral nerve cord (VNC) and in the brain, beginning at stage 13 and continuing through to stage 17. Colocalized with Gyc-89Db in several peripheral neurons that innervate trachea, basiconical sensilla and the sensory cones in the posterior segments of the embryo. Expression in wandering 3rd instar larvae is most prominent in a small cluster of cells located in the anterior medial region of each brain lobe. In the VNC, expression is found in scattered cells both laterally and at the midline.
messages: Heterodimer; with Gyc88E, in the presence of magnesium or manganese.
messages: Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
messages: Probably not activated by nitric oxide (NO). Heterodimer exhibits some stimulation, compounds (SIN-1 and two of the NONOates) that were ineffective at stimulating Gyc-88E homodimer did stimulate the heterodimer.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

7227:Dmel CG9273
gene id: 7227:Dmel_CG9273
uniprot id: Q9VIH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

7227:Dmel CG6622
gene id: 7227:Dmel_CG6622
uniprot id: A0A0B4KFT3
uniprot id: A8DYG9
uniprot id: D3DMK5
uniprot id: P05130
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Head neural tissue.
messages: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
messages: The sequence shown is that of Oregon-R.
messages: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.
messages: Up-regulated in the midgut epithelium in response to bacterial uracil.

7227:Dmel CG10198
gene id: 7227:Dmel_CG10198
uniprot id: Q9VCH5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nucleoporin GLFG family.
messages: Chromosome
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: Defective germline population maintenance and differentiation when both Nup98 and Nup96 are disrupted (PubMed:21949861). RNAi-mediated knockdown in the larval salivary glands results in reduced transcription of developmental genes Eip74EF and Eip75B and compromised transcriptional recovery after heat shock (PubMed:20144761). RNAi-mediated knockdown in the larva results in reduced expression of Hox genes such as Ubx and Antp (PubMed:25310983). RNA-mediated knockdown in the adult fly increases viral replication of Sindbis virus (SINV), vesicular stomatitis virus (VSV) and Drosophila C virus (DCV) (PubMed:25197089).
messages: Expressed during larval development (PubMed:20144761). Expressed in brain in third instar larvae (at protein level) (PubMed:28366641).
messages: Expressed in brain.
messages: Isoform A and isoform C are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively.
messages: Nucleus
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC) (PubMed:25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PubMed:20547758, PubMed:28554770). Plays a role in nuclear mRNA export (PubMed:28554770). Promotes cell antiviral response by up-regulating FoxK-dependent antiviral gene transcription (PubMed:25197089, PubMed:25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PubMed:21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PubMed:25201876).
messages: Part of the nuclear pore complex (NPC) (PubMed:25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PubMed:20144760, PubMed:20144761, PubMed:28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PubMed:28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PubMed:20144761, PubMed:25310983, PubMed:28366641).
messages: Part of the nuclear pore complex (NPC) (PubMed:25310983). Interacts with Rae1 (PubMed:21874015, PubMed:28554770). Nuclear pore complex protein Nup98: Interacts with pzg and Chro (PubMed:25310983). Interacts with MBD-R2; the interaction allows Nup98 recruitment to chromatin (PubMed:25310983). Interacts with Trx (PubMed:25310983). Interacts with Wds (PubMed:25310983). Interacts with Mtor and Cp190 (PubMed:28366641). Upon ecdysone stimulation, interacts with EcR, CTCF, su(Hw) and Trl (PubMed:28366641).
messages: Part of the nuclear pore complex (NPC).
messages: Up-regulated upon Drosophila C virus (DCV) or Sindbis virus (SINV) infection.
messages: nuclear pore complex
messages: nucleoplasm

7227:Dmel CG8949
gene id: 7227:Dmel_CG8949
uniprot id: Q9VX88
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-118' (By similarity). Regulates the cell-cycle checkpoint activation in response to DNA damage (By similarity). Positive regulator of amino acid starvation-induced autophagy (PubMed:26812014). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates Tor activity (PubMed:26812014). Promotes, in an energy-dependent manner, the assembly of the TTT complex and the RUVBL complex composed of pont and rept into the TTT-RUVBL complex (By similarity). This leads to dimerization of the mTORC1 complex and its subsequent activation (By similarity). May negatively regulate the ubiquitin proteasome pathway (By similarity). Required for habituation, a form of non-associative learning (PubMed:26757981).
messages: Expressed in adult head and thorax and in larval central nervous system and fat body.
messages: Lysosome
messages: Neurodegeneration, slow growth, decreased starvation-induced autophagy, increased basal autophagy and decreased Tor activity (PubMed:26812014). RNAi-mediated knockdown in neurons results in impaired habituation during a light-off jump reflex habituation assay where flies are exposed to a series of sudden light-off pulses and measured each time for a jump response (PubMed:26757981). Mutants fail to adapt their behavior and retain high average jump response throughout the experiment in contrast to controls which quickly habituate to the repeated light-off stimuli (PubMed:26757981).
messages: Nucleus

7227:Dmel CG8439
gene id: 7227:Dmel_CG8439
uniprot id: A1Z8U4
uniprot id: Q7KKI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7227:Dmel CG16752
gene id: 7227:Dmel_CG16752
uniprot id: Q8SWR3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed throughout development. Highest expression is in the embryos.
messages: Fully viable without obvious effects in the nervous system or reproductive organs (PubMed:18066048). Sperm transfer and storage in the females is not affected and egg fertilization and development is normal (PubMed:18066048). However, females lay fewer eggs, mate again at high frequency and do not reject a second male after mating (PubMed:18066048). Male and female flies display reduced overall sleep duration associated with shorter sleep-bout lengths, although the number of sleep-bouts is not affected (PubMed:25333796). Sleep recovery following sleep deprivation is also impaired (PubMed:25333796).
messages: In the female, expressed in the reproductive organs; strongly expressed in the spermathecae and the lower oviduct (PubMed:18066048). No expression in the male reproductive organs (PubMed:18066048). In the central nervous system of both sexes, it is expressed in the brain and ventral nerve cord (VNC); strongly expressed in the ventral regions of the suboesophageal ganglion, the cervical connective and in many nerve roots of the brain and VNC (PubMed:18066048, PubMed:25333796). Expressed in the s-LNvs and l-LNvs pdf neurons (at protein level) (PubMed:25333796).
messages: Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20458515, PubMed:20308537, PubMed:24089336, PubMed:25333796). MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796). SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336). The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336).

7227:Dmel CG4396
gene id: 7227:Dmel_CG4396
uniprot id: E1NZB4
uniprot id: Q9VYI0
names: Similarity
messages: Belongs to the RRM elav family.

7227:Dmel CG6249
gene id: 7227:Dmel_CG6249
uniprot id: Q9VKJ4
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG33748
gene id: 7227:Dmel_CG33748
uniprot id: D2NUJ1
uniprot id: P82890
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cone cells and primary pigment cells in developing pupal retina.
messages: Cytoplasm
messages: Larvae, pupae and adults.

7227:Dmel CG33755
gene id: 7227:Dmel_CG33755
uniprot id: Q9U5V6
names: Developmental Stage
names: Tissue Specificity
messages: During spermatogenesis.
messages: In bundles of maturing sperm of larval, pupal and adult males.

7227:Dmel CG6675
gene id: 7227:Dmel_CG6675
uniprot id: Q9V9P0
uniprot id: X2J9D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG5078
gene id: 7227:Dmel_CG5078
uniprot id: Q9VPD8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3006
gene id: 7227:Dmel_CG3006
uniprot id: Q9W1E9
names: Similarity
messages: Belongs to the FMO family.

7227:Dmel CG34224
gene id: 7227:Dmel_CG34224
uniprot id: Q6IGP6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG33281
gene id: 7227:Dmel_CG33281
uniprot id: Q8IPZ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG7303
gene id: 7227:Dmel_CG7303
uniprot id: C9QPG7
uniprot id: Q9VTN0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Dsx-dependent essential component of pheromone-driven courtship behavior (PubMed:12971900). Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating (PubMed:12971900). Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males (PubMed:26083710). Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the release of the neuropeptide tachykinin from a cluster of 8-10 neurons in the SEZ (PubMed:26083710).
messages: Expressed in chemosensory neurons of about 20 male-specific gustatory bristles in the forelegs (PubMed:12971900). No expression is seen in the mechanosensory neurons (PubMed:12971900). In larvae, expressed in the ventral pharyngeal sense organ (PubMed:22031876).
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mutant males display robust courtship behavior in the presence of CH503-perfumed females.

7227:Dmel CG11539
gene id: 7227:Dmel_CG11539
uniprot id: A0A0B4KHX9
uniprot id: Q9V9V9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Detected in syncytial embryos and larvae (at protein level).
messages: Interacts with microtubules as well as alpha/beta-tubulin heterodimers.
messages: N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin (PubMed:33479178). Required for microtubule stability and inhibition of JNK signaling to promote cell survival during development, possibly acting independently of its N-acetyltransferase activity (PubMed:33479178). Necessary for the stabilization of spindle microtubules and for mitosis progression (PubMed:33479178). Regulates microtubule stability by inhibiting Spastin-mediated depolymerization and promoting Eb1-mediated polymerization (PubMed:33479178).
messages: Nucleus
messages: RNAi-mediated knockdown in the posterior compartment of the wing disk, results in adult wings that are reduced in size, display abnormally thin veins and form blisters in the posterior part of the wing (PubMed:33479178). Defects are mainly due to activation of the JNK signaling pathway leading to increased apoptosis in the developing wing (PubMed:33479178). RNAi-mediated knockdown in the dorsoventral (DV) boundary and anterior-posterior (AP) boundary regions of the wing disk, induces notching along the adult wing margin and a reduction in the AP boundary region between the L3 and L4 veins (PubMed:33479178). RNAi-mediated knockdown in the adult thorax causes defects in the abdominal segments (PubMed:33479178). RNAi-mediated knockdown in the adult eyes induces ectopic tissue growth and reduced eye size (PubMed:33479178). RNAi-mediated knockdown in embryos, results in various abnormal mitotic patterns, such as defective chromosome alignments, short spindles and a loss of chromosomes (PubMed:33479178).
messages: spindle
messages: spindle pole

7227:Dmel CG4276
gene id: 7227:Dmel_CG4276
uniprot id: Q8IPW1
uniprot id: Q9VPU7
names: Similarity
messages: Belongs to the EPS8 family.

7227:Dmel CG7744
gene id: 7227:Dmel_CG7744
uniprot id: A1ZBL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

7227:Dmel CG5412
gene id: 7227:Dmel_CG5412
uniprot id: Q9VDL1
names: Similarity
messages: Belongs to the LovG family.

7227:Dmel CG7974
gene id: 7227:Dmel_CG7974
uniprot id: Q9W0A9
names: Similarity
messages: Belongs to the TLS1 family.

7227:Dmel CG7514
gene id: 7227:Dmel_CG7514
uniprot id: Q9VZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG43128
gene id: 7227:Dmel_CG43128
uniprot id: A8JNI9
uniprot id: M9MRU9
uniprot id: M9MRZ7
uniprot id: M9ND32
uniprot id: M9NFJ6
uniprot id: M9PE38
uniprot id: P17970
uniprot id: Q0E8I8
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Shab sub-subfamily.
messages: Expressed in late embryos and pupae.
messages: Heterotetramer of potassium channel proteins.
messages: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

7227:Dmel CG8475
gene id: 7227:Dmel_CG8475
uniprot id: M9PCI5
uniprot id: Q9VLS1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity).

7227:Dmel CG42335
gene id: 7227:Dmel_CG42335
uniprot id: Q9VD85
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG3388
gene id: 7227:Dmel_CG3388
uniprot id: B6IDY6
uniprot id: P09082
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed in segmentally repeating pattern to define the polarity of embryonic segments.
messages: Expressed in the posterior ventrolateral part of each segment throughout the embryo, including head and tail segments. At first expression is restricted to the ectoderm. During germ-band extension, expression is induced in the mesoderm.
messages: Nucleus

7227:Dmel CG12529
gene id: 7227:Dmel_CG12529
uniprot id: B7FNK0
uniprot id: P12646
uniprot id: X2JEF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
messages: Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
messages: cytosol

7227:Dmel CG2128
gene id: 7227:Dmel_CG2128
uniprot id: Q7KTS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

7227:Dmel CG8337
gene id: 7227:Dmel_CG8337
uniprot id: O97178
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the M4-like protein family.
messages: Mesectodermal expression appears shortly before the onset of gastrulation. Later it is detected in the neuro-ectoderm as well as in the mesoderm in a highly dynamic pattern in many stages of embryogenesis. In imaginal disks, expressed as following: in the eye disk, within and posterior to the morphogenetic furrow; in the wing pouch, in the presumptive intervein regions and wing margin; in the leg disk, general expression.
messages: Part of the Notch signaling pathway.

7227:Dmel CG8491
gene id: 7227:Dmel_CG8491
uniprot id: Q9VW47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for leg and eye development and macrochaete specification or differentiation.
messages: Nucleus

7227:Dmel CG9023
gene id: 7227:Dmel_CG9023
uniprot id: A0A0B4KET4
uniprot id: A0A0B4KFD6
uniprot id: A0A0B4KFN8
uniprot id: A0A0B4LG55
uniprot id: F3YDC9
uniprot id: H6V591
uniprot id: Q9V5Z7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel.
messages: Homotetramer.
messages: Membrane

7227:Dmel CG9247
gene id: 7227:Dmel_CG9247
uniprot id: Q9VIF1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the mut-7 family.
messages: Homozygous semilethal and sterile. Mutant flies show accumulation of the longest isoforms of multiple-isoform miRNAs including miR-3 and miR-34.
messages: Interacts with AGO1; the interaction is not RNA dependent.
messages: Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation.

7227:Dmel CG8722
gene id: 7227:Dmel_CG8722
uniprot id: Q7K2X8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adults develop normally, however females display ovarian defects and reduced fertility likely due to the significant decrease in TORC1 activity within the germline cells (PubMed:21521741, PubMed:25512509). Ovarian defects include adherent cyst divisions due to mitotic delay, accumulation of autolysosomes resulting in reduced number of egg chambers and reduced number of eggs laid per female per day (PubMed:21521741, PubMed:25512509). Spindle defects and mitotic delay results in egg chambers often containing 16 polyploid nurse cells and no oocyte because the oocyte enters the endocycle and develops as a polyploid nurse cell (PubMed:21521741). In early meiotic germline cells, the nucleoporin Mtor is displaced from the nuclear envelope to the nucleoplasm, most notably as cysts enter the meiotic cycle beginning in R2a of the germarium (PubMed:21521741). However, there is no effect on the recruitment of Mtor or other nucleoporins (Nup107, Nup153, Mtor and FG-containing nucleoporins) to the nuclear pore complex (PubMed:21521741). In contrast, somatic tissues do not display any obvious developmental defects; there is no decrease in TORC1 activity and no accumulation of autolysosomes in the larval fat body (PubMed:25512509, PubMed:21521741, PubMed:27166823). Increasing TORC1 activity in the mutant female germline via RNAi-mediated knockdown of the GATOR1 subcomplex members Nprl2, Nprl3, Iml1 or knockdown of Tsc1 rescues the ovarian defects (PubMed:25512509). However, knockdown of Nprl2 or Nprl3 does not rescue the accumulation of autolysosomes (PubMed:27166823).
messages: An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238, PubMed:25512509). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation growth under nutrient replete conditions and growth during female oocyte development (PubMed:21521741, PubMed:25512509, PubMed:23723238, PubMed:27166823). This component is required for activating TORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate, probably influences the organization and/or function of microtubules within ovarian cysts, and promotes accumulation of another GATOR2 complex member mio in germline and somatic tissues (PubMed:27166823, PubMed:23723238, PubMed:25512509, PubMed:21521741). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the TORC1 complex, functions independently of TORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823).
messages: Belongs to the WD repeat SEC13 family.
messages: Expressed in ovarian cysts.
messages: Lysosome
messages: Nucleus envelope
messages: Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823).
messages: Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells (PubMed:21521741). It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC (PubMed:21521741).

7227:Dmel CG16771
gene id: 7227:Dmel_CG16771
uniprot id: Q9VIW9
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG1420
gene id: 7227:Dmel_CG1420
uniprot id: F3YDP8
uniprot id: Q9VAQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

7227:Dmel CG17941
gene id: 7227:Dmel_CG17941
uniprot id: Q24292
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell junction
messages: Cell membrane
messages: Expressed in embryonic ectoderm. In larvae, expression is restricted to imaginal disks and brain.
messages: Expressed throughout embryogenesis where it is first detected during gastrulation. Also expressed in larvae and adults.
messages: Interacts (via cytoplasmic region) with Myo31DF.
messages: Overexpression in segment H1 of the imaginal ring causes aberrant gut looping in about 40% of the cases, but no phenotype is observed when both Myo31DF and ds are overexpressed.
messages: Phosphorylated by fj on Ser/Thr of cadherin domains.
messages: RNAi-mediated knockdown in subdomain H1 of the imaginal ring causes loss of H2 cell orientation bias, resulting in aberrant looping of the adult hindgut.
messages: Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:7601355, PubMed:26073018). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018).

7227:Dmel CG3029
gene id: 7227:Dmel_CG3029
uniprot id: Q9W1E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

7227:Dmel CG2304
gene id: 7227:Dmel_CG2304
uniprot id: Q7KRW1
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Expressed in oocytes throughout development.
messages: Interacts with VHL. Interacts with the MPN domain of CSN5. Interacts with EIF3F and EIF3H.
messages: Intron retention.
messages: Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development.
messages: The RING-type zinc finger domain may be essential for ubiquitin ligase activity.

7227:Dmel CG11980
gene id: 7227:Dmel_CG11980
uniprot id: Q8INP8
uniprot id: Q8INP9
uniprot id: Q9VHI8
names: Similarity
messages: Belongs to the MYG1 family.

7227:Dmel CG9288
gene id: 7227:Dmel_CG9288
uniprot id: Q9VFR1
names: Function
names: Similarity
messages: Belongs to the ABITRAM family.
messages: May regulate actin polymerization.

7227:Dmel CG4201
gene id: 7227:Dmel_CG4201
uniprot id: Q9VEZ5
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated; upon LPS stimulation it is transiently activated, and can be autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
messages: Cytoplasm
messages: Expressed both maternally and zygotically throughout development. Highest expression is in early embryos and third larval instar.
messages: Interacts with key to form the I-kappa-B kinase complex. In vitro, interacts with cact.
messages: Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel (PubMed:10636911, PubMed:11018014, PubMed:11156609, PubMed:30119996). Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor (PubMed:10636911, PubMed:11018014, PubMed:11156609). Essential for antibacterial immune response (PubMed:11018014). Also required for antiviral immune response (PubMed:30119996).

7227:Dmel CG12110
gene id: 7227:Dmel_CG12110
uniprot id: A4UZ54
uniprot id: B7YZT5
uniprot id: Q7KML4
names: Similarity
messages: Belongs to the phospholipase D family.

7227:Dmel CG15171
gene id: 7227:Dmel_CG15171
uniprot id: Q9VJ18
names: Similarity
messages: Belongs to the GAMAD family.

7227:Dmel CG5488
gene id: 7227:Dmel_CG5488
uniprot id: M9PHF0
uniprot id: Q24256
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: B-H1 and B-H2 are abundant in the eye-antenna imaginal disk. Expressed in R1 and R6 cells throughout larval stage until 30 hours after puparium formation, at which time expression is seen in the anterior and posterior primary pigment cells. Coexpressed in embryonic glial cells, neurons of the CNS and PNS, most latitudinal anterior cells of the developing notum and the central circular region of the leg and antennal imaginal disk throughout larval development.
messages: B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
messages: Belongs to the Antp homeobox family.
messages: Coexpressed at high levels with B-H1 in embryo and pupae and at low levels in larvae.
messages: Nucleus

7227:Dmel CG10990
gene id: 7227:Dmel_CG10990
uniprot id: Q9VY91
names: Similarity
messages: Belongs to the PDCD4 family.

7227:Dmel CG8708
gene id: 7227:Dmel_CG8708
uniprot id: A0A0B4K711
uniprot id: Q7JRF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

7227:Dmel CG3380
gene id: 7227:Dmel_CG3380
uniprot id: Q9W269
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG11221
gene id: 7227:Dmel_CG11221
uniprot id: Q9VM90
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Activated by Pka-C1-mediated phosphorylation of Ser-334.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Expressed broadly in the third instar larvae and adult flies (at protein levels).
messages: Expressed in the mushroom bodies (at protein level).
messages: Meng-Po is the Lady of Forgetfulness, a character in Chinese mythology, who ensures that people are ready for reincarnation by providing the 'Tea of Forgetfulness' that makes them loose the memories associated with their former life.
messages: Results in a decreased CrebB protein translation or stability in the brain. RNAi-mediated knockdown in the mushroom bodies results in a reduction of memory formation, including anesthesia-sensitive memory (ASM) and long-term memory (LTM) performance but not anesthesia-resistant memory (ARM) or learning ability.
messages: Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM).

7227:Dmel CG8029
gene id: 7227:Dmel_CG8029
uniprot id: Q7JR49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump (By similarity). May interact with ATP6AP2 (PubMed:29995586).
messages: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles.
messages: Belongs to the vacuolar ATPase subunit S1 family.
messages: Endoplasmic reticulum membrane

7227:Dmel CG15016
gene id: 7227:Dmel_CG15016
uniprot id: M9NDH8
uniprot id: Q9VZD5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7227:Dmel CG17141
gene id: 7227:Dmel_CG17141
uniprot id: Q9VCU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity).

7227:Dmel CG11251
gene id: 7227:Dmel_CG11251
uniprot id: Q9VU50
names: Similarity
messages: Belongs to the FAH family.

7227:Dmel CG9780
gene id: 7227:Dmel_CG9780
uniprot id: Q9VN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG14899
gene id: 7227:Dmel_CG14899
uniprot id: Q9VEU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

7227:Dmel CG7091
gene id: 7227:Dmel_CG7091
uniprot id: Q9VG14
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG12906
gene id: 7227:Dmel_CG12906
uniprot id: A1Z881
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG10246
gene id: 7227:Dmel_CG10246
uniprot id: Q27594
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG1074
gene id: 7227:Dmel_CG1074
uniprot id: Q960G1
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

7227:Dmel CG8909
gene id: 7227:Dmel_CG8909
uniprot id: B5X533
uniprot id: Q9VXM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11152
gene id: 7227:Dmel_CG11152
uniprot id: Q9V481
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8426
gene id: 7227:Dmel_CG8426
uniprot id: Q7K126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

7227:Dmel CG13281
gene id: 7227:Dmel_CG13281
uniprot id: Q9XZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPO2/CSE1 family.
messages: Binds with high affinity to importin-alpha only in the presence of RanGTP.
messages: Cytoplasm
messages: Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).
messages: Nucleus

7227:Dmel CG11027
gene id: 7227:Dmel_CG11027
uniprot id: L0MNA8
uniprot id: P40945
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Uniformly distributed throughout adults.

7227:Dmel CG9102
gene id: 7227:Dmel_CG9102
uniprot id: M9PBH6
uniprot id: Q9W0K4
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
messages: Leg imaginal disk at the central region of the tarsus and in eye antenna disk at the basal cylinder.
messages: Nucleus
messages: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.

7227:Dmel CG1418
gene id: 7227:Dmel_CG1418
uniprot id: A1Z823
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

7227:Dmel CG3289
gene id: 7227:Dmel_CG3289
uniprot id: Q9VQQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG5190
gene id: 7227:Dmel_CG5190
uniprot id: Q7JUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: May function in mitochondrial tRNA maturation.
messages: Mitochondrion

7227:Dmel CG18493
gene id: 7227:Dmel_CG18493
uniprot id: Q9VDX6
names: Similarity
messages: Belongs to the peptidase S28 family.

7227:Dmel CG13795
gene id: 7227:Dmel_CG13795
uniprot id: Q9VLY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG1129
gene id: 7227:Dmel_CG1129
uniprot id: E2QCZ9
uniprot id: Q7JZB4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

7227:Dmel CG42253
gene id: 7227:Dmel_CG42253
uniprot id: M9PB59
uniprot id: M9PB60
uniprot id: M9PC92
uniprot id: M9PC95
uniprot id: M9PCF0
uniprot id: M9PCT2
uniprot id: M9PF01
uniprot id: Q8IPI3
uniprot id: Q9VM31
uniprot id: Q9VM32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

7227:Dmel CG2774
gene id: 7227:Dmel_CG2774
uniprot id: Q9VQQ6
uniprot id: X2J8I7
names: Similarity
messages: Belongs to the sorting nexin family.

7227:Dmel CG3245
gene id: 7227:Dmel_CG3245
uniprot id: Q7KVM5
names: Similarity
messages: Belongs to the PPP phosphatase family.

7227:Dmel CG6045
gene id: 7227:Dmel_CG6045
uniprot id: Q9VF51
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG7034
gene id: 7227:Dmel_CG7034
uniprot id: Q9VDE6
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Detected in developing rhabdomeres in photoreceptor cells.
messages: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8 (By similarity). Interacts with RAB3, RAB8, RAB11 and RAB27.

7227:Dmel CG11665
gene id: 7227:Dmel_CG11665
uniprot id: Q7JWI7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG17974
gene id: 7227:Dmel_CG17974
uniprot id: Q9W2H3
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG15386
gene id: 7227:Dmel_CG15386
uniprot id: Q9VQ88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

7227:Dmel CG14100
gene id: 7227:Dmel_CG14100
uniprot id: Q9VW14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1580 (Gm1580) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

7227:Dmel CG3655
gene id: 7227:Dmel_CG3655
uniprot id: M9PGK1
uniprot id: Q9V3U1
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7227:Dmel CG18090
gene id: 7227:Dmel_CG18090
uniprot id: P09040
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the gastrin/cholecystokinin family.
messages: Expressed at all developmental stages.
messages: Expressed in larval brain tissue localizing to cells in the anterior and medial protocerebrum. Expressed in cells in the brain lobe, optic lobe, subesophageal ganglion, thoracic ganglia and the eighth abdominal neuromere. Drosulfakinin-0 is expressed in the central nervous system including the subesophageal ganglion and an abdominal ganglion.
messages: In adults, RNAi-mediated knockdown in insulin-producing cells or all Dsk-expressing cells, increases total food intake and the number of feeding bouts over a 24 hour period (PubMed:25187989). However, feeding them the CCK antagonist SR 27897 does not result in a further increase in total food intake and feeding bouts, as in wild-type adults (PubMed:25187989).
messages: Involved in diverse biological roles including regulating aspects of gut function, satiety and food ingestion, hyperactivity, and aggression (PubMed:17632121, PubMed:24142897, PubMed:25187989). Regulates gut muscle contraction in adults but not in larvae (PubMed:17632121). Functions downstream of TfAP-2 and twz in octopamine signaling pathways to modulate feeding and male aggression (PubMed:24142897, PubMed:25187989). Inhibits consummatory behavior in adults and functions as part of a negative feedback loop with TfAP-2 and twz to prevent overeating; TfAP-2 and twz regulate octopamine signaling to initiate feeding, then octopamine activates expression of Dsk in insulin-producing cells (IPCs) to inhibit feeding (PubMed:25187989).
messages: Secreted
messages: Up-regulated 24 hours after starvation and then appears to return to normal expression levels 48 hours after nutritional starvation.

7227:Dmel CG30403
gene id: 7227:Dmel_CG30403
uniprot id: Q8MLV3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4926
gene id: 7227:Dmel_CG4926
uniprot id: D9PTS3
uniprot id: Q24488
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Expressed in neurons of the developing nervous system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

7227:Dmel CG11419
gene id: 7227:Dmel_CG11419
uniprot id: Q9V831
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
messages: The APC is composed of at least 11 subunits.

7227:Dmel CG14941
gene id: 7227:Dmel_CG14941
uniprot id: Q24338
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat ESC family.
messages: Component of the Esc/E(z) complex, composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho. The Esc/E(z) complex may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.
messages: Expressed both maternally and zygotically. Strongly expressed in the oocyte and in early embryos, then decreases at the end of embryogenesis. Weakly expressed in third instar larvae. Transiently required between 2 and 6 hours of embryogenesis to establish PcG silencing and promote viable adults.
messages: Nucleus
messages: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
messages: Widely expressed.

7227:Dmel CG7264
gene id: 7227:Dmel_CG7264
uniprot id: Q9VTP5
names: Similarity
messages: Belongs to the RIB43A family.

7227:Dmel CG18369
gene id: 7227:Dmel_CG18369
uniprot id: A1Z9G3
names: Similarity
messages: Belongs to the peptidase M17 family.

7227:Dmel CG15899
gene id: 7227:Dmel_CG15899
uniprot id: A8JUY8
uniprot id: M9NDQ0
uniprot id: M9NGR9
uniprot id: M9PGH9
uniprot id: Q9W433
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3523
gene id: 7227:Dmel_CG3523
uniprot id: B7Z001
uniprot id: Q9VQL7
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

7227:Dmel CG6518
gene id: 7227:Dmel_CG6518
uniprot id: P13677
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Exclusively expressed in photoreceptor cells.
messages: Expression primarily in adults.
messages: Tetrapeptide ligand at C-terminus is tethered to inaD by interaction with the second PDZ domain.
messages: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
messages: Up-regulated in the midgut epithelium in response to bacterial uracil.

7227:Dmel CG5864
gene id: 7227:Dmel_CG5864
uniprot id: A0A0B4KHB7
uniprot id: B8A403
uniprot id: Q9VCF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Golgi apparatus
messages: clathrin-coated pit

7227:Dmel CG8153
gene id: 7227:Dmel_CG8153
uniprot id: Q24595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPC family.
messages: Heterodimer.
messages: Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity).
messages: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
messages: Nucleus

7227:Dmel CG1891
gene id: 7227:Dmel_CG1891
uniprot id: A0A0B4K7J3
uniprot id: Q7JQ36
uniprot id: Q95U21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Belongs to the scoloptoxin-05 family.
messages: Membrane

7227:Dmel CG6255
gene id: 7227:Dmel_CG6255
uniprot id: Q9VDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

7227:Dmel CG10146
gene id: 7227:Dmel_CG10146
uniprot id: P45884
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the attacin/sarcotoxin-2 family.
messages: By bacterial infection (at protein level).
messages: Hemolymph (at protein level).
messages: Hemolymph antibacterial protein.
messages: Secreted

7227:Dmel CG42853
gene id: 7227:Dmel_CG42853
uniprot id: C0PDE0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG6612
gene id: 7227:Dmel_CG6612
uniprot id: Q9VGU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

7227:Dmel CG9572
gene id: 7227:Dmel_CG9572
uniprot id: E8NH67
uniprot id: M9MSF5
uniprot id: Q9W5X1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17645
gene id: 7227:Dmel_CG17645
uniprot id: Q9VGB6
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7227:Dmel CG9314
gene id: 7227:Dmel_CG9314
uniprot id: Q9VLI6
names: Similarity
messages: Belongs to the catalase family.

7227:Dmel CG11059
gene id: 7227:Dmel_CG11059
uniprot id: L0MQ08
uniprot id: Q9V498
uniprot id: X2J9E8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds synaptic Ca(2+) with its cytoplasmic domain.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: May modulate calcium-mediated postsynaptic signals.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Vesicle
messages: neuron projection

7227:Dmel CG4311
gene id: 7227:Dmel_CG4311
uniprot id: Q7K4Q9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

7227:Dmel CG17914
gene id: 7227:Dmel_CG17914
uniprot id: Q9VJI5
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG3203
gene id: 7227:Dmel_CG3203
uniprot id: Q9W3W8
uniprot id: X2JIQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

7227:Dmel CG15296
gene id: 7227:Dmel_CG15296
uniprot id: Q9W2T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG10882
gene id: 7227:Dmel_CG10882
uniprot id: M9PC99
uniprot id: Q9VQ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG9778
gene id: 7227:Dmel_CG9778
uniprot id: A0A0B4KF61
uniprot id: Q9VN04
names: Similarity
messages: Belongs to the synaptotagmin family.

7227:Dmel CG1505
gene id: 7227:Dmel_CG1505
uniprot id: O62589
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9618496, PubMed:9477324, PubMed:12493753). Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324). Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324).
messages: Expressed both maternally and zygotically.
messages: Expression begins in previtellogenic stages and is seen in germline-derived nurse cells of the germarium. Expression continues throughout oogenesis with transcripts from the nurse cells accumulating in the oocytes. Most abundant in the ovaries, the level of protein decreases from the moment of egg laying and is essentially gone by 4 hours.
messages: Intron retention.
messages: Secreted

7227:Dmel CG17916
gene id: 7227:Dmel_CG17916
uniprot id: Q9VDM1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG18214
gene id: 7227:Dmel_CG18214
uniprot id: Q7KVD1
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG7620
gene id: 7227:Dmel_CG7620
uniprot id: Q9VG00
names: Similarity
messages: Belongs to the COX20 family.

7227:Dmel CG42381
gene id: 7227:Dmel_CG42381
uniprot id: B7YZN8
names: Similarity
messages: Belongs to the CMC4 family.

7227:Dmel CG32260
gene id: 7227:Dmel_CG32260
uniprot id: M9PE97
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Secreted
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG9149
gene id: 7227:Dmel_CG9149
uniprot id: Q9W0H6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7227:Dmel CG7454
gene id: 7227:Dmel_CG7454
uniprot id: Q9VHS4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG7815
gene id: 7227:Dmel_CG7815
uniprot id: D7PER7
uniprot id: Q9VUN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with tamo (PubMed:12653959).
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

7227:Dmel CG3018
gene id: 7227:Dmel_CG3018
uniprot id: Q7KNM2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG1057
gene id: 7227:Dmel_CG1057
uniprot id: A0A0B4K6R3
uniprot id: A0A0B4KG28
uniprot id: A0A0B4LGM8
uniprot id: Q8IH24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene.
messages: Component of the Mediator complex, which includes at least MED4, MED6, MED14, MED17, MED18, MED20, MED21, MED23, MED24, MED27, MED30 and MED31.
messages: Component of the Mediator complex.
messages: Nucleus

7227:Dmel CG31507
gene id: 7227:Dmel_CG31507
uniprot id: D3PFI0
uniprot id: Q8IN42
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A humoral factor that may play a role in stress tolerance.
messages: Belongs to the Turandot family.
messages: By a variety of stressful conditions such as bacterial infection, heat shock, paraquat feeding and exposure to ultraviolet light.
messages: Expressed in the early pupae.
messages: Secreted

7227:Dmel CG3820
gene id: 7227:Dmel_CG3820
uniprot id: Q9W1X4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (PubMed:14638854). Interacts with mbo/Nup88 and (via C-terminus) with emb to attenuate emb-mediated protein export (PubMed:14638854, PubMed:17032737).
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG-rich region is required for emb localization to the nuclear pore complex.
messages: Nucleus membrane
messages: Part of the nuclear pore complex (PubMed:14638854). Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad (PubMed:17682050, PubMed:20547758, PubMed:17032737). Protects mbo/Nup88 from proteasomal degradation at the nuclear pore (PubMed:17032737). Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export (PubMed:17032737). Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response (PubMed:17032737).
messages: nuclear pore complex

7227:Dmel CG8342
gene id: 7227:Dmel_CG8342
uniprot id: O97176
names: Developmental Stage
messages: Expressed at the time when separation of neural and epidermal precursor cells occurs. Accumulates transiently at the fusion sites of anterior and posterior midgut and very specifically to high levels in the proventriculus of the embryo. Not expressed in the imaginal disks of third instar larvae.

7227:Dmel CG6817
gene id: 7227:Dmel_CG6817
uniprot id: M9PES6
uniprot id: Q9VSL7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Expressed both maternally and zygotically.
messages: Glycosylated.
messages: Maternal foi has almost completely disappeared by embryonic stage 3 except in the pole cells. In stage 6 embryos, expression is enriched in the invaginating mesoderm. In stage 9 embryos, high levels in the anterior and posterior midgut primordia. In stage 14 embryos, broad expression with low levels in the epidermis.
messages: Membrane
messages: Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells.

7227:Dmel CG6745
gene id: 7227:Dmel_CG6745
uniprot id: Q9VSK9
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Neurological defects, characterized by behavioral disorders, including increased activity, disorientation, and aggressiveness (PubMed:30526862). Impaired pseudouridylation oF tRNAS (PubMed:30526862).
messages: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs, such as tRNAs and mRNAs.

7227:Dmel CG13106
gene id: 7227:Dmel_CG13106
uniprot id: Q9VLE5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to propyl acetate and anisole.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG5962
gene id: 7227:Dmel_CG5962
uniprot id: A8E775
uniprot id: P19107
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the arrestin family.
messages: Inner and outer segments, and the inner plexiform regions of the retina.
messages: Phosphorylated upon light exposure.
messages: Probably plays an important role in the photoreceptor transduction.

7227:Dmel CG6773
gene id: 7227:Dmel_CG6773
uniprot id: Q9V3J4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:27166823).
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Expressed during larval development.
messages: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II (PubMed:20144761). Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development (PubMed:20144761). Required for reactivation of transcription after heat shock (PubMed:20144761). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
messages: Lysosome membrane
messages: Nucleus envelope
messages: Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with msk (PubMed:20547758). Interacts (preferentially when phosphorylated) with Mad (PubMed:20547758).
messages: RNAi-mediated knockdown in the larva results in reduced transcription of developmental genes Eip74EF and Eip75B in the salivary glands, compromised transcriptional recovery after heat shock and defective recruitment of Nup98.
messages: Salivary glands.
messages: centrosome
messages: nuclear pore complex
messages: nucleoplasm

7227:Dmel CG3278
gene id: 7227:Dmel_CG3278
uniprot id: Q9V9M6
names: Similarity
messages: Belongs to the RRN3 family.

7227:Dmel CG9826
gene id: 7227:Dmel_CG9826
uniprot id: Q9W1Z0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8332
gene id: 7227:Dmel_CG8332
uniprot id: A1ZAH8
uniprot id: Q7JZW2
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

7227:Dmel CG18550
gene id: 7227:Dmel_CG18550
uniprot id: A0A0B4KGZ1
uniprot id: A0A0B4KHA3
uniprot id: Q9VG09
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major royal jelly protein family.
messages: Expressed in larvae and pupae, with highest levels in later larval and early pupal stages. Very low expression in 1-day-old adults.
messages: Incomplete sequence.
messages: Secreted
messages: Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages.

7227:Dmel CG10923
gene id: 7227:Dmel_CG10923
uniprot id: M9PF35
uniprot id: Q9VSW5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG1793
gene id: 7227:Dmel_CG1793
uniprot id: Q9V4F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 26 family.
messages: Component of the Mediator complex (By similarity). Interacts with MED6 and MED17.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene.
messages: Nucleus

7227:Dmel CG1133
gene id: 7227:Dmel_CG1133
uniprot id: P39768
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Expressed throughout all segment primordia; expressed ubiquitously in the ectoderm and mesoderm precursors.
messages: Nucleus
messages: The peak expression is seen between 2 and 12 hours of embryogenesis. Expression continues through the larval instars and during pupation although at lower levels compared with embryogenesis.
messages: Transcription factor essential for parasegmental subdivision of the embryo. It is involved in the activation of wingless (wg) in odd parasegments. It is also required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments.

7227:Dmel CG1471
gene id: 7227:Dmel_CG1471
uniprot id: A4V3N7
uniprot id: Q9VA70
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neutral ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition.
messages: N-glycosylated.
messages: Overexpression rescues retinal degeneration in arrestin and phospholipase C mutants, probably by facilitating membrane turnover and endocytosis of rhodopsin in photoreceptors.
messages: Secreted
messages: Widely expressed in different tissues but enriched in neurons at all stages of development.

7227:Dmel CG5543
gene id: 7227:Dmel_CG5543
uniprot id: Q9W1J3
names: Similarity
messages: Belongs to the WD repeat GAD-1 family.

7227:Dmel CG30085
gene id: 7227:Dmel_CG30085
uniprot id: Q9XZ34
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RIF1 family. Highly divergent.
messages: Chromosome
messages: Embryos have a reduced hatch rate and develop into adults with reduced survival (PubMed:29746464). During mid-blastula transition in embryos, S phase 14 is significantly shorter (PubMed:29746464). In larval salivary glands, loss of DNA underreplication resulting in abnormally enlarged chromocenters (PubMed:30277458). RNAi-mediated knockdown results in lethality (PubMed:26022086). Escaper flies only live for a few days and are infertile (PubMed:26022086). Females show increased necrotic spots in the abdominal segments (PubMed:26022086). RNAi-mediated knockdown in the imaginal disks does not affect viability (PubMed:26022086).
messages: Expressed in embryos at high levels between 0-2 hours; from 8 to 14 hours, the highest levels are in the brain then diminishes to negligible levels (at protein level) (PubMed:22712556, PubMed:26022086, PubMed:29746464). Expressed in larval imaginal disks and salivary glands (at protein level) (PubMed:26022086). Detected in larvae at lower levels in imaginal disks, the central nervous system and ovary and, at extremely low levels, in testis (PubMed:26022086).
messages: Expressed in nurse cells and follicle cells in the adult female (at protein level) (PubMed:26022086, PubMed:30277458). Detected in adult at extremely low levels (PubMed:26022086).
messages: Interacts with Pp1-87b (PubMed:26022086, PubMed:29746464). Interacts with SuUR (via SNF2-like region) (PubMed:30277458).
messages: Nucleus
messages: Phosphorylated, probably by Cdk1; phosphorylation regulates dissociation from heterochromatin.
messages: Regulates the timing of initiation of DNA replication (PubMed:29746464, PubMed:30277458, PubMed:26022086). Functions in copy number control by promoting the underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes (PubMed:30277458). Promotes underreplication by localizing to active DNA replication forks in a partially SuUR-dependent manner, and inhibiting replication fork progression (PubMed:30277458). Might also work as an adapter to recruit Pp1-87B to multiple sites on the chromosome and may function with Pp1-87B to mediate underreplication (PubMed:26022086, PubMed:29746464, PubMed:30277458). Plays an essential role in embryonic development, in the transition from larvae to pupae and, probably, in proliferating tissues later on (PubMed:26022086, PubMed:29746464). In embryos, during mid-blastula transition, binds to and selectively delays the replication of large blocks of repetitive DNA satellite sequences during S phase in response to the activity of Cdk1; maternal Rif1 is specifically required for the normal extension of S phase 14 (PubMed:29746464). Unlike mammalian orthologs, does not appear to play a role in DNA damage repair (PubMed:22712556, PubMed:26022086).
messages: telomere

7227:Dmel CG6283
gene id: 7227:Dmel_CG6283
uniprot id: Q9VB90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG11048
gene id: 7227:Dmel_CG11048
uniprot id: Q7K2N1
names: Subcellular Location Annotation
messages: cilium axoneme

7227:Dmel CG9122
gene id: 7227:Dmel_CG9122
uniprot id: Q9W0K2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

7227:Dmel CG7385
gene id: 7227:Dmel_CG7385
uniprot id: Q9VW78
names: Similarity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

7227:Dmel CG3180
gene id: 7227:Dmel_CG3180
uniprot id: A0A0B4LI86
uniprot id: P08266
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
messages: Nucleus
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

7227:Dmel CG17028
gene id: 7227:Dmel_CG17028
uniprot id: Q9VUW3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG7157
gene id: 7227:Dmel_CG7157
uniprot id: Q9V3R1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected in the male accessory glands (at protein level) (PubMed:24514904). Produced in the accessory glands and secreted into seminal fluid (PubMed:9474779).
messages: Proteolytically cleaved by the seminal metalloprotease Semp1 (PubMed:24514904). Cleavage appears to take place in the mated female (PubMed:24514904).
messages: Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
messages: Secreted

7227:Dmel CG12765
gene id: 7227:Dmel_CG12765
uniprot id: A1Z9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

7227:Dmel CG31644
gene id: 7227:Dmel_CG31644
uniprot id: Q8T970
uniprot id: X2J713
uniprot id: X2JD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Membrane

7227:Dmel CG5068
gene id: 7227:Dmel_CG5068
uniprot id: Q95R98
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated.

7227:Dmel CG5361
gene id: 7227:Dmel_CG5361
uniprot id: Q9VH28
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG6764
gene id: 7227:Dmel_CG6764
uniprot id: Q9VGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24 (By similarity).
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).
messages: nucleolus

7227:Dmel CG4231
gene id: 7227:Dmel_CG4231
uniprot id: I6LTZ3
uniprot id: P81910
names: Caution
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed with Orco in 20-22 sensory neurons on the medial-proximal edge of the antenna. This expression pattern matches the distribution of the large sensilla basiconica. Expression is first seen at 60 hours APF in a subset of cells restricted to a subregion of the developing antenna. Expression continues throughout antennal development. Expressed in the ab3A neuron which responds to ethyl butyrate.
messages: Interacts with Orco, via conserved C-terminal cytoplasmic loops. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Intron retention and rearrangement of DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG7920
gene id: 7227:Dmel_CG7920
uniprot id: Q9VAC1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

7227:Dmel CG7791
gene id: 7227:Dmel_CG7791
uniprot id: A1Z6H6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

7227:Dmel CG32403
gene id: 7227:Dmel_CG32403
uniprot id: E5AJI4
uniprot id: P82984
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG8948
gene id: 7227:Dmel_CG8948
uniprot id: X2JDY8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: GTPase-activating protein for Rho family proteins (PubMed:33835025). Essential component of the CLIC (clathrin-independent carrier)/GEEC (GPI-anchored protein-enriched early endocytic compartment) endocytic pathway (PubMed:28993397). During hematopoiesis, inhibits Egfr-ras-MAPK signaling by promoting Spi-induced Egfr internalization through CLIC/GEEC endocytosis, thereby preventing plasmatocyte overproliferation (PubMed:28993397). Essential for normal mushroom body (MB) development and consequently the formation of olfactory long-term memories (PubMed:33892766). During MD development, required to stop the MB beta-lobe from crossing the brain midline, possibly acting via its role in the CLIC/GEEC endocytic pathway to down-regulate the Egfr-ras-MAPK signaling at the tip of the beta-lobes (PubMed:33892766). Required during embryo cellularization for maintaining and regulating the rate of actomyosin ring constriction (PubMed:33835025). During cellularization, inhibits Rho-GTP levels at the furrow canal tip in a spatiotemporal manner, thus delaying the onset of actomyosin contraction and ensuring appropriate closure of the cells at the base of nuclei after membrane extension (PubMed:33835025).
messages: In the adult brain, expressed in the antennal lobe, the subesophageal ganglion and the alpha/beta neurons of the mushroom body.
messages: In the larval primary lymph gland, expressed throughout the medullary and cortical zones (at protein level). Also detected in larval and embryo plasmatocytes (at protein level).
messages: Interacts with Egfr (when ubiquitinated).
messages: RNAi-mediated knockdown in embryos is lethal at 24 hr, likely due to defective cellularization (PubMed:33835025). During cellularization, the F-actin network at the base of the furrow canal is unorganized, the furrow tips contain wavy edges and there is a loss of contact between adjacent furrow tips (PubMed:33835025). Actomyosin ring constriction is enhanced, and the nuclei have a bottleneck appearance likely due to premature constriction at the furrow canal tip during the mid cellularization stage (PubMed:33835025). Another study reports that flies are viable and fertile (PubMed:28993397). RNAi-mediated knockdown in the alpha/beta neurons of the adult mushroom body (MB), results in abnormal crossing of the MB beta lobe over the brain midline (PubMed:33892766).
messages: The Rho-GAP domain is necessary for inhibiting contractile ring constriction during cellularization.
messages: cytosol

7227:Dmel CG42780
gene id: 7227:Dmel_CG42780
uniprot id: M9MS21
uniprot id: X2JAR4
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG11377
gene id: 7227:Dmel_CG11377
uniprot id: M9PDP6
uniprot id: Q9VPJ0
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG15065
gene id: 7227:Dmel_CG15065
uniprot id: A1ZB63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bomanin family.
messages: Hemolymph.
messages: Secreted
messages: Secreted immune-induced peptide induced by Toll signaling (PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489).

7227:Dmel CG4015
gene id: 7227:Dmel_CG4015
uniprot id: P11450
names: Tissue Specificity
messages: Expressed in follicle cells during vitelline membrane formation.

7227:Dmel CG7108
gene id: 7227:Dmel_CG7108
uniprot id: Q24317
names: Activity Regulation
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6773966, PubMed:6806812, PubMed:6812052, PubMed:6403945, PubMed:6409898). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Can add both ribo- and deoxynucleotides during elongation of the primers (PubMed:6812052). Binds single stranded DNA (By similarity).
messages: Expressed both maternally and zygotically. Expression is very low in late embryos, larvae, pupae and adult males.
messages: Expressed in embryos (at protein level).
messages: Heterodimer of a catalytic subunit Prim1 and a regulatory subunit Prim2, also known as the DNA primase complex (PubMed:6403945, PubMed:6409898). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit PolA1, the regulatory subunit PolA2, and the primase complex subunits Prim1 and Prim2 respectively (PubMed:6773966, PubMed:6403945, PubMed:6409898). PolA1 associates with the DNA primase complex before association with PolA2 (PubMed:6409898).
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
messages: The presence of the regulatory subunit Prim2 accelerates the kinetics of initiation and primer extension.

7227:Dmel CG1017
gene id: 7227:Dmel_CG1017
uniprot id: Q9W062
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MFAP1 family.
messages: Component of the spliceosome B complex (By similarity). Interacts (via C-terminus) with Prp38.
messages: Nucleus
messages: Required for pre-mRNA splicing.

7227:Dmel CG10694
gene id: 7227:Dmel_CG10694
uniprot id: Q9VCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

7227:Dmel CG6349
gene id: 7227:Dmel_CG6349
uniprot id: P26019
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DNA polymerase type-B family.
messages: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9858578, PubMed:6773966, PubMed:6806812, PubMed:6403945, PubMed:6409898). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (PubMed:9858578, PubMed:6773966, PubMed:6806812, PubMed:6409898). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In addition to polymerase activity, exhibits 3' to 5' exonuclease activity (PubMed:3112771, PubMed:3129427).
messages: Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit PolA1, the regulatory subunit PolA2, and the primase complex subunits Prim1 and Prim2 respectively (PubMed:6773966, PubMed:6403945, PubMed:6409898, PubMed:7592543). PolA1 associates with the DNA primase complex before association with PolA2 (PubMed:6409898). Interacts with Dpit47; the interaction inhibits the activity of the DNA polymerase and occurs only in proliferating cells but not in quiescent cells (PubMed:11493638).
messages: Expressed both maternally and zygotically. Highest level of zygotic expression seen in second-instar larva, level is reduced at other stages of development.
messages: Expressed in embryos (at protein level).
messages: In embryos, a cleaved form of 130 kDa is produced up to cycle 14 and then disappears.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Inhibited by N2-(p-n-butylphenyl) deoxyguanosine 5'-triphosphate and N2-(p-n-butylphenyl) deoxyadenosine 5'-triphosphate (PubMed:3129427). DNA synthesis is not inhibited by fungal toxin alpha-amaitin (PubMed:6806812). The 3'-5' exonuclease activity is inhibited by 10mM dGMP (PubMed:3129427).
messages: Nucleus
messages: The CysA-type zinc finger is required for PCNA-binding.

7227:Dmel CG12021
gene id: 7227:Dmel_CG12021
uniprot id: Q9NB04
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Patj family.
messages: Component of the SAC complex, a complex composed of crb, Patj and sdt. Interacts directly with nrx via its third and fourth PDZ domains. Interacts directly with par-6, possibly mediating a link between the SAC complex and the par-6 complex, which is composed of par-6, baz and aPKC.
messages: Expressed both maternally and zygotically. Appears in mitotic cycle 11 when the furrows made by the imprint of the embryonic nuclei become apparent.
messages: Expressed in primary and some secondary epithelial cells such as ectodermal cells, salivary glands, foregut, hindgut and invaginating tracheal cells. Also expressed in specific cells of the peripheral nervous system. Expressed in the germline.
messages: Involved in cell polarity establishment. Probably participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex.
messages: Membrane
messages: Was originally thought to be the Disks lost (Dlt) protein. However, PubMed:14667407 showed that it is not the case and renamed it Patj. This drastically changes the first conclusions drawn about its essential function, since the mutant used contained defects for another protein, which is now called Dlt. If its association with proteins involved in cell polarization complexes is clear, Patj is not essential since its absence apparently does not lead to important defects.

7227:Dmel CG16973
gene id: 7227:Dmel_CG16973
uniprot id: Q7KV88
uniprot id: Q7KV89
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7227:Dmel CG32258
gene id: 7227:Dmel_CG32258
uniprot id: P83296
uniprot id: Q7KV53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: Membrane
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast.
messages: Plays a role in the sugar gustatory response.

7227:Dmel CG30493
gene id: 7227:Dmel_CG30493
uniprot id: B5RJR6
uniprot id: Q8MKN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

7227:Dmel CG14818
gene id: 7227:Dmel_CG14818
uniprot id: O97420
names: Similarity
messages: Belongs to the UPF0184 (EST00098) family.

7227:Dmel CG14704
gene id: 7227:Dmel_CG14704
uniprot id: A0A0B4K741
uniprot id: A4V2P5
uniprot id: Q8INK6
names: Cofactor
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Binds 1 zinc ion per subunit.
messages: Does not contain a signal sequence.
messages: Expressed from old embryos. Expressed in larvae and adults.
messages: Monomer.
messages: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
messages: Secreted
messages: Strongly up-regulated by PGN from B.subtilis. Regulated by the imd/Relish pathway.
messages: Widely expressed.

7227:Dmel CG42783
gene id: 7227:Dmel_CG42783
uniprot id: A0A0B4JD78
uniprot id: A0A0B4KEQ8
uniprot id: A0A0B4KEV2
uniprot id: A0A0B4KFQ6
uniprot id: A0A0B4KG15
uniprot id: A1Z9X0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apicolateral cell membrane
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Expressed in the testis. In spermatid cysts, localizes near the tips of spermatid flagellar axonemes (at protein level). Detectable in freshly laid eggs before onset of zygotic transcription so is deposited in the egg during oogenesis. At the cellular blastoderm stage, present in all cells except the pole cells. During gastrulation, strongly expressed in tissues undergoing morphogenetic movements such as invaginating mesoderm, proctodeum and cephalic furrow. Strongly expressed in neuroblasts.
messages: Interacts with baz; the interaction is required for apical localization of aPKC in neuroblasts and epithelial cells. Interacts with Dap160; the interaction promotes aPKC apical localization and kinase activity. Interacts with and phosphorylates l(2)gl and yrt. Interacts with crb and ref(2)P. Forms a complex with baz, fz and Patj.
messages: Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.
messages: Zygotes survive to mid-larval stages where they exhibit defects in neuroblast and epithelial cell polarity. Mutant neuroblasts lack apical localization of l(2)gl and par-6, and fail to exclude mira from the apical cortex. Oocytes do not differentiate and display failure of BicD and ORB to translocate from the anterior to the posterior crescent, accumulation of Dhc64C in the two posterior-most presumptive pre-oocytes instead of in a single cell as normal, and defective posterior assembly of the microtubule organizing center. Adherens junctions form atypical planar-polarized puncta at gastrulation. Reduced yrt phosphorylation.
messages: cell cortex

7227:Dmel CG8404
gene id: 7227:Dmel_CG8404
uniprot id: P40657
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG32616
gene id: 7227:Dmel_CG32616
uniprot id: Q9NIV2
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG10327
gene id: 7227:Dmel_CG10327
uniprot id: Q8SXP8
uniprot id: Q9W1I0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4849
gene id: 7227:Dmel_CG4849
uniprot id: Q9VAX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

7227:Dmel CG4258
gene id: 7227:Dmel_CG4258
uniprot id: Q9VPU8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Expression is detected in nurse cells during oogenesis throughout stage 10A and persists through stage 14 with some expression in the anterior part of the oocyte. Expression is ubiquitously detected at all stages of embryogenesis. Observed in salivary gland cells from heat shocked transgenic third instar larvae.
messages: Homozygous mutant larvae show arrested development at the first instar stage as they fail to increase in size or develop into the second instar larval stage and die 2-3 days after hatching, without morphological defect. Mutant larvae show an overall reduction of most intermediate and mature rRNA as a consequence of abnormal pre-rRNA processing. Mutants show defects in rRNA processing and aberrant pre-rRNA species. An abnormal cleavage in the 3'-end of the pre-rRNA occurs within the presumptive 28S rRNA but it does not lead to accumulation of a truncated 28S rRNA.
messages: Monomer. Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.
messages: nucleolus

7227:Dmel CG6196
gene id: 7227:Dmel_CG6196
uniprot id: Q9VF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

7227:Dmel CG10240
gene id: 7227:Dmel_CG10240
uniprot id: A0A0B4LGH5
uniprot id: Q9V769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG34384
gene id: 7227:Dmel_CG34384
uniprot id: A0A0B4K634
uniprot id: A0A0B4K6B6
uniprot id: A0A0B4K6W3
uniprot id: A0A0B4LHW4
uniprot id: A8JQ65
uniprot id: E2QD61
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Cytoplasm
messages: Frameshift and deletion of residues 1685-1699.
messages: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

7227:Dmel CG8885
gene id: 7227:Dmel_CG8885
uniprot id: Q9VMX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

7227:Dmel CG3558
gene id: 7227:Dmel_CG3558
uniprot id: M9PB19
uniprot id: Q9VQK0
names: Similarity
messages: Belongs to the FHIP family.

7227:Dmel CG6570
gene id: 7227:Dmel_CG6570
uniprot id: A0A0B4KH37
uniprot id: Q9VDA2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG32473
gene id: 7227:Dmel_CG32473
uniprot id: Q8INH5
uniprot id: Q8INH6
uniprot id: Q9VFW7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG30084
gene id: 7227:Dmel_CG30084
uniprot id: A1ZA47
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: Expression is first detected in the proctodeum and the midgut primordium. In stage 11 embryos, expression is predominant in the leading edge of epidermal cells adjacent to the amnioserosa. Stage 12 embryos exhibit expression in the midgut and the leading edge. Expressed in several rows of germ band cells next to the leading edge at stage 14. Strong expression is visible in the midgut and pharyngeal muscles of stage 17 embryos. Also expressed in somatic muscles and visceral mesoderm. Colocalizes with mys (beta PS integrin) in myotendinous junctions and with Actn in muscle Z lines.
messages: Fails to form the muscle Z line. At the myotendinous junction, muscles detach with the onset of contractility.
messages: Interacts with alpha-actinin (Actn).
messages: Intron retention.
messages: Regulator of cell matrix adhesion having two related functions, one upstream of Actn organizing the Z line and the other downstream of integrins regulating assembly of integrin adhesion sites. Also required for the formation of myotendinous junctions in muscles.
messages: cytoskeleton

7227:Dmel CG13090
gene id: 7227:Dmel_CG13090
uniprot id: M9PCK7
uniprot id: Q9VLJ8
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Also essential during biosynthesis of the molybdenum cofactor (By similarity). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:26715182). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (By similarity). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A (By similarity). Subsequently, a transient disulfide bond is formed (PubMed:26715182). Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity).
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
messages: RNAi-mediated knockdown results in reduced levels of urmylation and increased resistance to oxidative stress.

7227:Dmel CG7942
gene id: 7227:Dmel_CG7942
uniprot id: Q9VSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).
messages: Nucleus

7227:Dmel CG9389
gene id: 7227:Dmel_CG9389
uniprot id: Q9VP62
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG44123
gene id: 7227:Dmel_CG44123
uniprot id: Q9W4Q1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10324
gene id: 7227:Dmel_CG10324
uniprot id: Q9VES0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG9906
gene id: 7227:Dmel_CG9906
uniprot id: Q9VXF6
names: Similarity
messages: Belongs to the calreticulin family.

7227:Dmel CG6329
gene id: 7227:Dmel_CG6329
uniprot id: Q7K188
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Belongs to the scoloptoxin-05 family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG11699
gene id: 7227:Dmel_CG11699
uniprot id: Q9VYX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

7227:Dmel CG6113
gene id: 7227:Dmel_CG6113
uniprot id: M9MRM3
uniprot id: Q9VKT9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG9494
gene id: 7227:Dmel_CG9494
uniprot id: Q9VLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG34351
gene id: 7227:Dmel_CG34351
uniprot id: M9PCK0
uniprot id: Q059C4
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

7227:Dmel CG33180
gene id: 7227:Dmel_CG33180
uniprot id: M9MS57
uniprot id: M9MSB0
uniprot id: M9MSD3
uniprot id: M9MSN9
uniprot id: Q9GQN0
uniprot id: X2JFC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exportin family.
messages: Binds to nucleoporins and the GTP-bound form of Ran.
messages: Cytoplasm
messages: May function as a nuclear transport receptor.
messages: Nucleus

7227:Dmel CG33470
gene id: 7227:Dmel_CG33470
uniprot id: C0HLZ9
uniprot id: C0HM00
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection (at protein level) (PubMed:9736738, PubMed:16510152). Detected within 24 hours of infection (PubMed:9736738). Up-regulated in the fat body following infection with M.luteus, with expression levels increasing from 2 to 48 hours post infection (PubMed:34432851). In adults, also up-regulated in the head including the border of the eyes and the ocelli, and in the brain tissue including the region posterior to the central brain furrow (PubMed:34432851). Up-regulated in the wing veins, along the borders of the thoracic pleura, and in the spermatheca of females (PubMed:34432851). In larvae, induced in the brain tissue at the posterior of the ventral nervous system (PubMed:34432851).
messages: Hemolymph (at protein level).
messages: In some wild flies and common laboratory strains, the BaraA locus has undergone a duplication event to produce two identical paralogs, BaraA1 and BaraA2 (PubMed:34432851). However BaraA copy number varies within these strains indicating that the duplication event is recent and not fixed (PubMed:34432851).
messages: Proteolytically cleaved.
messages: Secreted
messages: Secreted immune-induced peptides induced by Toll signaling (PubMed:9736738, PubMed:34432851). Has a significant role in resistance to infection by the entomopathogenic fungus B.bassiana R444 and weak antifungal activity against M.rileyi PHP1705 (PubMed:34432851). In adult males, activity appears to be important for neuromuscular processes that mediate correct wing posture upon Toll activation (PubMed:34432851).
messages: The name 'Baramicin' derives from the Japanese idiom Bara-Bara, meaning to break apart, and refers to the multiple peptides produced from the precursor protein.
messages: Viable with no obvious morphological defects, however flies have an increased susceptibility to entomopathogenic fungi (PubMed:34432851). Displays increased fungal load 48 hours after infection with B.bassiana R444 spores resulting in a significant decrease in survival (PubMed:34432851). Survival is also slightly decreased following septic injury with M.rileyi PHP1705 (PubMed:34432851). Some adult males display an erect wing phenotype upon infection with Gram-positive bacteria, fungi, and to a lesser extent, Gram-negative bacteria and clean injury (PubMed:34432851). Males also display the erect wing phenotype after injury with heat-killed E.faecalis suggesting that the phenotype occurs due to Toll activation and is not the result of infection (PubMed:34432851). No effect on activation of the Toll or imd/NF-kappa-B signaling cascades in response to microbial infection (PubMed:34432851). No significant affect on lifespan, resistance to bacterial infection and survival following clean injury (PubMed:34432851).

7227:Dmel CG3193
gene id: 7227:Dmel_CG3193
uniprot id: P17886
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the crooked-neck family.
messages: Causes defects in the proliferation of brain neuroblasts and results in the absence of identified neuronal lineages in the central and peripheral nervous systems (PubMed:2044955). During embryonic Malpighian morphogenesis, most of the cells of the Malpighian tubules fail to undergo rearrangement to form tubes with a two cell circumference. Only cells at the distal end of the tubule rearrange (PubMed:10502111).
messages: Colocalizes with a complex containing snRNP proteins.
messages: Is expressed throughout embryonic, larval, pupal and adult stages at relatively constant levels.
messages: May be involved in pre-mRNA splicing process (PubMed:12163015, PubMed:2044955). Involved in embryonic neurogenesis and cell rearrangement during Malpighian tubule morphogenesis (PubMed:2044955, PubMed:10502111).
messages: Nucleus speckle
messages: Transcribed in all cells during embryonic development.

7227:Dmel CG11849
gene id: 7227:Dmel_CG11849
uniprot id: A0A0B4KHU6
uniprot id: A0A0B4KI14
uniprot id: Q9VBW6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Coexpressed with danr in the presumptive distal antenna, but not in the leg imaginal disk. Both proteins are also expressed in the brain and the eye region of the eye-antenna disk. First detected in early L3 eye disks in cells surrounding the newly initiated MF. Levels are uniform and high anterior to the furrow, lower levels within and posterior to the furrow. Limited expression is seen in small groups of cells in leg and wing. These appear in the location of prominent sense organ progenitors at relatively late stages of disk development.
messages: Flies exhibit partial transformation of antenna toward leg identity and small rough eyes. Ectopic expression causes partial transformation of distal leg structures toward antennal identity and antennal precursors into eye tissue.
messages: Homomers. Interacts with itself, danr, ey and dac to form a complex (or complexes) containing the RD factors.
messages: Nucleus
messages: Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.

7227:Dmel CG13248
gene id: 7227:Dmel_CG13248
uniprot id: Q9VPG2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG17593
gene id: 7227:Dmel_CG17593
uniprot id: Q9VQR9
names: Subcellular Location Annotation
messages: Membrane
messages: Rough endoplasmic reticulum membrane

7227:Dmel CG33756
gene id: 7227:Dmel_CG33756
uniprot id: M9PFK4
uniprot id: P22468
names: Developmental Stage
names: Similarity
names: Tissue Specificity
messages: Belongs to the gonadal family.
messages: During oogenesis and spermatogenesis.
messages: In stage 6-14 egg chamber nurse cells and oocytes of adult females and spermatocyte cysts and bundles of maturing sperm of larval, pupal and adult males.

7227:Dmel CG7362
gene id: 7227:Dmel_CG7362
uniprot id: Q9VFG4
names: Similarity
messages: Belongs to the pyruvate kinase family.

7227:Dmel CG7490
gene id: 7227:Dmel_CG7490
uniprot id: M9PG76
uniprot id: P19889
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All stages of development. A larger transcript is restricted to the embryonic and early larval stages.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Cytoplasm
messages: Nucleus
messages: P0 forms a pentameric complex by interaction with dimers of P1 and P2.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

7227:Dmel CG33135
gene id: 7227:Dmel_CG33135
uniprot id: A0A0B4KEH2
uniprot id: A0A0B4KEI9
uniprot id: A0A0B4KEP9
uniprot id: A0A0B4KF62
uniprot id: A0A0B4KFJ4
uniprot id: A1Z856
uniprot id: B7YZR3
uniprot id: B7YZR4
uniprot id: Q5PXF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG10642
gene id: 7227:Dmel_CG10642
uniprot id: Q9VRK9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG1513
gene id: 7227:Dmel_CG1513
uniprot id: A0A0B4KEI3
uniprot id: A1Z814
uniprot id: E1JH23
names: Similarity
messages: Belongs to the OSBP family.

7227:Dmel CG7478
gene id: 7227:Dmel_CG7478
uniprot id: M9PFZ6
uniprot id: P02574
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: Expressed during larval stages and at a lower level in pupae.
messages: In Drosophila there are 6 closely related actin genes.
messages: Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
messages: Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
messages: cytoskeleton

7227:Dmel CG13793
gene id: 7227:Dmel_CG13793
uniprot id: Q9VLY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG12325
gene id: 7227:Dmel_CG12325
uniprot id: Q5U0X8
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

7227:Dmel CG33977
gene id: 7227:Dmel_CG33977
uniprot id: Q2PDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

7227:Dmel CG31721
gene id: 7227:Dmel_CG31721
uniprot id: M9MRI4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Defective axonal patterning of terminal processes in class IV nociceptive sensory neurons (C4da), including defective contralateral projections in ddaC and vdaB neurons, during larval development (PubMed:22084112, PubMed:21338947, PubMed:24746793). Defective larval locomotion behavior (PubMed:22084112). Defective targeting of R8 photoreceptor growth cones to the medulla layer during eye development (PubMed:27743477).
messages: Detected at embryonic stages 13-14 (PubMed:22084112). During embryonic and larval development, expressed in the ventral nerve cord (VNC) in a subset of peripheral nervous system neurons including C4da (at protein level) (PubMed:22084112, PubMed:21338947, PubMed:24746793).
messages: E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra (PubMed:22084112, PubMed:21338947). Regulates fine-scale topography of C4da axon terminals upon neuronal activity (PubMed:24746793). During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra (PubMed:27743477).
messages: Induced by neuronal activity in C4da neurons.
messages: Interacts (via fibronectin type-III domain) with pico. Interacts (via SPRY domain) with netrin receptor fra.
messages: Perikaryon
messages: The fibronectin type-III, SPRY and coil-coil domains are necessary for C4da axon patterning.
messages: axon

7227:Dmel CG8291
gene id: 7227:Dmel_CG8291
uniprot id: Q0E961
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Expressed in third instar eye disks.
messages: Membrane
messages: Putative sodium-dependent transporter which is required for viability, early imaginal disk development and adult motor coordination (PubMed:17890365). Also has a role in the fate commitment of the R3/R4 photoreceptor cells (PubMed:17890365). May function in ommatidial polarity by regulating the activity of the core polarity genes, acting upstream of (or in parallel to) Vang, dsh, pk, stan, and dgo, but downstream or independently of fz (PubMed:17890365).
messages: The imaginal disks of third instar larvae are dramatically decreased in size (PubMed:17890365). Overall larval size is unaffected (PubMed:17890365).
messages: The name 'bedraggled' derives from escaper mutant adults which upon eclosion, immediately fall into their food and die due to severe defects in motor coordination.

7227:Dmel CG4755
gene id: 7227:Dmel_CG4755
uniprot id: Q9VDS5
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

7227:Dmel CG34407
gene id: 7227:Dmel_CG34407
uniprot id: A0A0B4LEZ3
uniprot id: A8DY80
uniprot id: A8DY81
uniprot id: A8DY82
uniprot id: E2QCN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

7227:Dmel CG11340
gene id: 7227:Dmel_CG11340
uniprot id: Q9V9Y4
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: In third-instar larvae, expressed in the principal cells of the excretory Malpighian tubules (at protein level) (PubMed:32269334, PubMed:27358471). Also detected in the enterocytes of the copper cell region and the iron cell region of the larval midgut (at protein level) (PubMed:32269334). In the copper cell region expression is confined to the interstitial cells and in the iron cell region it is expressed in the anterior portion (at protein level) (PubMed:32269334). Expressed in the Malpighian tubules and the middle midgut of third instar larvae and adults (PubMed:27172217).
messages: Larval lethal (PubMed:32269334). Larval development is delayed due to decreased food intake and reduced systematic insulin signaling (PubMed:32269334). However, escapers eventually attain a normal size during the pupal and adult stages (PubMed:32269334). Unlike in wild-type larvae, mutants do not develop a preference for zinc supplemented food or eat more when fed a zinc rich diet (PubMed:32269334). The copper cell region of the larval midgut displays developmental and functional defects such as reduced luminal acidity, increased bacterial titers and enlarged cell volume (PubMed:32269334). The interstitial cells also display increased cell volume due to reduced basal infolding (PubMed:32269334). They also display an increased tolerance to copper but not zinc, likely due to increased cell acidity which has been found to decrease copper uptake (PubMed:27172217). Postembryonic knockdown specifically in interstitial and Malpighian tubule principal cells also results in reduced food intake and increased time to pupation, whereas knockdown only in principal cells, iron cells or copper cells has no effect on larval development (PubMed:32269334). Mutants display a further increase in developmental delay in a Tor RNAi-mediated background (PubMed:32269334).
messages: Late endosome membrane
messages: Ligand and pH-gated channel that mediates chloride transport primarily in the mid-gut and thereby functions in larval metabolism and fluid homeostasis (PubMed:32269334, PubMed:27358471, PubMed:27172217). Channel opening is triggered by zinc binding or, to a lesser extent, an increase in extracellular pH (PubMed:32269334, PubMed:27358471). Zinc-dependent activity in the mid-gut is required for modulating Tor-dependent metabolic programs that promote larval feeding and systematic growth (PubMed:32269334). It may therefore act as an intestinal zinc sensor that mediates larval growth and metabolism in response to micronutrient availability (PubMed:32269334). Activates Tor signaling via its activity in maintaining lysosome homeostasis in interstitial cells and/or by its role in activating the release of insulin-like peptides in the brain after feeding, via an unknown mechanism (PubMed:32269334). Functions in lysosome homeostasis by regulating chloride transport into enterocyte lysosomes to sustain V-ATPase function which maintains lysosomal acidification and consequently promotes Tor activation at the lysosome membrane (PubMed:32269334). Also appears to play a role in regulating fluid secretion and osmotic homeostasis in Malpighian tubules in response to the pH of extracellular urine (PubMed:27358471). This function is important for proper urine production during diuresis (PubMed:27358471).
messages: Lysosome membrane
messages: Probable cloning artifact.
messages: The name 'hodor' is an acronym for 'hold on, don't rush', referring to the developmental delay phenotype in mutants.
messages: microvillus membrane

7227:Dmel CG12287
gene id: 7227:Dmel_CG12287
uniprot id: H0RNL2
uniprot id: P31369
uniprot id: Q9VK71
uniprot id: X2J9L4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family.
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
messages: Expressed primarily during the first half of embryogenesis.
messages: Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.
messages: Nucleus

7227:Dmel CG9095
gene id: 7227:Dmel_CG9095
uniprot id: A8JUX3
uniprot id: M9PHT4
uniprot id: Q9VXX7
uniprot id: X2JBY1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG2144
gene id: 7227:Dmel_CG2144
uniprot id: A1Z705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG14612
gene id: 7227:Dmel_CG14612
uniprot id: A0A0B4LGS3
uniprot id: Q9VI60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated AMEX complex (anchoring and mRNA export complex), composed of at least e(y)2 and xmas-2. Component of the SAGA transcription coactivator-HAT complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and Nipped-A/Trrap. Within the SAGA complex, e(y)2, Sgf11, and not/nonstop form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Component of the THO complex, composed of at least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7. Interacts with e(y)1. Interacts with su(Hw) (via zinc fingers). Interacts with xmas-2; required for localization to the nuclear periphery. Interacts with the nuclear pore complex (NPC).
messages: Cytoplasm
messages: Expressed specifically in testis.
messages: Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in transcription elongation by recruiting the THO complex onto nascent mRNA. The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: Testis-specific paralog of the ubiquitously expressed transcription and mRNA export factor e(y)2. Cannot functionally replace e(y)2.
messages: nucleoplasm

7227:Dmel CG34089
gene id: 7227:Dmel_CG34089
uniprot id: B6E0Q2
uniprot id: P18933
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

7227:Dmel CG2346
gene id: 7227:Dmel_CG2346
uniprot id: P10552
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: In insects, FMRFamide and related peptides have modulatory actions at skeletal neuromuscular junctions, and peptides that are immunologically related to FMRFamide are released into the circulation from neurohemal organs.
messages: Secreted
messages: This precursor includes 13 peptides that have FMRF or related sequences at their C-termini, and other putative neuropeptides.

7227:Dmel CG2125
gene id: 7227:Dmel_CG2125
uniprot id: H5V858
uniprot id: H9XVL6
uniprot id: H9XVL7
uniprot id: P19538
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
messages: In embryos, expressed uniformly throughout the blastoderm stage and gastrulation (from stage 5). During stage 10, ci is eliminated from the posterior compartment of each segment forming 15 segmentally repeating stripes at the end of the short phase of germ-band extension.
messages: Interacts with RDX (PubMed:16740475). Interacts with cos (PubMed:9244298, PubMed:15691767). Interacts with slmb; the interaction is enhanced by phosphorylation by CkIalpha and dco (PubMed:16326393).
messages: Nucleus
messages: Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylation is essential for its proteolytic processing. cos recruits multiple kinases to promote efficient phosphorylation of ci while Hh signaling inhibits phosphorylation by restricting the accessibility of ci to the kinases (PubMed:15691767). Phosphorylation by CkIalpha and dco enhances binding to Slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing (PubMed:16326393).
messages: Polyubiquitinated by RDX in the presence of CUL3, which results in proteasomal degradation.
messages: RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora. Abolishes Cad99C-dependent formation of endosomes and DUOX-dependent up-regulation of reactive oxygen species (ROS) in the intestines of adults fed bacteria-derived uracil.
messages: Transcriptional repressor ciR, a C-terminally truncated form, is generated from the full-length ci (ciFL/ci-155) through proteolytic processing. Hh suppresses the formation of ci75 and promotes the conversion of ci155 into a transcriptional activator (ci155A).

7227:Dmel CG8183
gene id: 7227:Dmel_CG8183
uniprot id: A0A0B4KFR5
uniprot id: A0A0B4KG24
uniprot id: A0A0B4LGK5
uniprot id: A1ZA18
uniprot id: A4UZI0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG18642
gene id: 7227:Dmel_CG18642
uniprot id: O76462
names: Similarity
messages: Belongs to the LovG family.

7227:Dmel CG30145
gene id: 7227:Dmel_CG30145
uniprot id: Q9V938
names: Function
names: Similarity
messages: Belongs to the PBP/GOBP family.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.

7227:Dmel CG17662
gene id: 7227:Dmel_CG17662
uniprot id: Q9W1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7227:Dmel CG8713
gene id: 7227:Dmel_CG8713
uniprot id: Q7JZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG11551
gene id: 7227:Dmel_CG11551
uniprot id: Q7KUL4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4523
gene id: 7227:Dmel_CG4523
uniprot id: Q0KHV6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a serine/threonine-protein kinase (PubMed:16672980, PubMed:18799731, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Exhibits a substrate preference for proline at position P+1 and a general preference at several residues for basic residues such as arginine (By similarity). Also exhibits moderate preferences for a phosphotyrosine at position P-3 and a tryptophan at P-5 (By similarity). Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as park and likely Drp1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:16672980, PubMed:18799731, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:23509287, PubMed:24901221, PubMed:25474007). Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18443288, PubMed:18799731, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:32138754). Mediates the translocation and activation of park at the outer membrane (OMM) of dysfunctional/d…
messages: Adults display various phenotypes that appear to be the result of mitochondrial abnormalities and/or mitochondrial dysfunction (PubMed:16672980, PubMed:16672981, PubMed:18799731, PubMed:18443288, PubMed:24901221, PubMed:27906179, PubMed:30772175). In various tissues including the indirect flight muscles (IFM), thoracic muscles, sperm, cardiomyocytes and neurons including the dopaminergic (DA) neurons, mitochondria display abnormalities such as swelling, loss of cristae, fragmentation, aggregation and/or mitochondrial disorganization, and they are dysfunctional resulting in defects such as mitochondrial depolarization, increased reactive oxygen species (ROS) production, reduced ATP, decreased mitochondrial DNA and reduced mitochondrial protein levels (PubMed:16672980, PubMed:16672981, PubMed:18443288, PubMed:18799731, PubMed:24901221, PubMed:27906179, PubMed:23509287). As a result adults are reduced in size, display reduced survival and decreased fertility (PubMed:16672980, PubMed:16672981, PubMed:18799731). They also exhibit age-dependent and progressive degradation of the IFM and DA neurons, especially in the protocerebral posterior lateral 1 (PPL1) cluster, which likely contribute to the observed locomotive defects, down-turned rigid wings and crushed thorax phenotypes (PubMed:16672980, PubMed:18443288, PubMed:24901221, PubMed:27906179). Also affects non-motor behaviors such as reduced learning, intermediate-term memory and irregular circadian rhythms under constant darkness, likely as a result of the neurodegradation (PubMed:28435104). On the surface of mitochondria enriched with a deleterious mutation, negative regulation of larp-mediated protein synthesis is reduced, and as a consequence the transmission of the deleterious mtDNA mutation to the mature oocyte is more random compared to control oocytes which display decreased inheritance of the mutation (PubMed:30772175). RNAi-mediated knockdown increases the net velocity of anterograde mitochondrial transport in…
messages: Autophosphorylated on Ser-346, which activates kinase activity (PubMed:25474007, PubMed:27906179). Loss of mitochondrial membrane potential results in the precursor accumulating on the outer mitochondrial membrane (OMM) where it is activated by autophosphorylation at Ser-346 (PubMed:27906179). Autophosphorylation is sufficient and essential for selective recruitment of park to depolarized mitochondria, likely via Pink1-dependent phosphorylation of polyubiquitin chains (PubMed:25474007, PubMed:27906179).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Expressed throughout development, with high levels of expression in adults and low levels of expression in larvae and pupae (PubMed:16672980, PubMed:16672981). Adult males display higher levels of expression than females (PubMed:16672980).
messages: High expression in the brain and retinas (PubMed:16938835). High expression in the head and testes (PubMed:16672981). High expression in the thorax compared to the head and abdomen (PubMed:16672980).
messages: Interacts with park (PubMed:19048081). Interacts with rho-7 and HtrA2 (PubMed:19048081).
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Proteolytically cleaved (PubMed:19048081). In healthy cells, the precursor is continuously imported into mitochondria where it is proteolytically cleaved into its short form by the mitochondrial rhomboid protease rho-7 (PubMed:19048081). The short form is then released into the cytosol where it rapidly undergoes proteasome-dependent degradation (Probable). In unhealthy cells, when cellular stress conditions lead to the loss of mitochondrial membrane potential, mitochondrial import is impaired leading to the precursor accumulating on the outer mitochondrial membrane (OMM) (PubMed:27906179).
messages: cytosol

7227:Dmel CG18190
gene id: 7227:Dmel_CG18190
uniprot id: A1ZBF1
names: Similarity
messages: Belongs to the MAPRE family.

7227:Dmel CG14507
gene id: 7227:Dmel_CG14507
uniprot id: Q8IML0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

7227:Dmel CG10189
gene id: 7227:Dmel_CG10189
uniprot id: Q9VIV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

7227:Dmel CG17450
gene id: 7227:Dmel_CG17450
uniprot id: Q8I044
uniprot id: Q8IRZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7227:Dmel CG7638
gene id: 7227:Dmel_CG7638
uniprot id: Q9VTF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

7227:Dmel CG30446
gene id: 7227:Dmel_CG30446
uniprot id: A1Z6N4
names: Similarity
messages: Belongs to the group II decarboxylase family.

7227:Dmel CG11875
gene id: 7227:Dmel_CG11875
uniprot id: Q9VBU8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: (Microbial infection) After infection with E.chaffeensis, results in reduced bacterial replication rate and increased survival.
messages: (Microbial infection) Required for optimal replication of E.chaffeensis.
messages: As part of the nuclear pore complex (NPC), has a role in its assembly and function.
messages: nuclear pore complex

7227:Dmel CG11880
gene id: 7227:Dmel_CG11880
uniprot id: C4XVJ5
uniprot id: Q9VAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7227:Dmel CG9809
gene id: 7227:Dmel_CG9809
uniprot id: Q8IPM0
uniprot id: Q8IPM1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4459
gene id: 7227:Dmel_CG4459
uniprot id: Q9VDR9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32251
gene id: 7227:Dmel_CG32251
uniprot id: Q8IRB5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the claspin family.
messages: Detected in the ovary but not in the testis (at protein level).
messages: Expressed during S phase, in a cell-cycle-dependent fashion. Expression levels are highest in embryos (0-4 hours old) and in the ovaries of adult females. Little to no expression in larvae and pupae (at protein level).
messages: Hatch rate of embryos is less than one percent. Nuclear morphology of embryos is normal until the 10th nuclear cycle when the shape and size of nuclei becomes abnormal and surface nuclei also begin to exhibit an irregular distribution. The phosphorylation of Cdk1 at the mid-blastula transition (between 2 to 4 hours after egg deposition) is also severely delayed. Increased sensitivity to HU with reduced survival rates. In the eye disks from mutant third stage larvae treated with HU, there is a higher percentage of mitotic cells compared to untreated mutant larvae. Is insensitive to ionizing radiation; the percentage of mitotic cells is unaffected in the eye disks of larvae treated with IR, and IR-induced apoptosis in larvae also appears to be unaffected.
messages: Nucleus
messages: Phosphorylated in response to DNA damage by IR and HU treatment. Phosphorylation does not require mei-41 or tefu.
messages: Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells.

7227:Dmel CG30030
gene id: 7227:Dmel_CG30030
uniprot id: P58961
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr57a subfamily.
messages: Cell membrane
messages: Expressed in neurons of the terminal external chemosensory organ of larvae.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG12220
gene id: 7227:Dmel_CG12220
uniprot id: Q9V9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Mitochondrion

7227:Dmel CG13650
gene id: 7227:Dmel_CG13650
uniprot id: Q9VBX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG5809
gene id: 7227:Dmel_CG5809
uniprot id: Q9V438
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein disulfide isomerase family.
messages: Binds to both apoptotic cells and phagocytes and promotes Drpr-dependent phagocytosis of apoptotic cells.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Expressed throughout development from embryo to adult.
messages: In the blastoderm embryo, expression starts at the anterior and posterior poles and later appears as broad stripes. Following gastrulation, expressed in midline precursor cells and the posterior head with low levels present throughout the embryo. During germ band extension, weak dorsoventral stripes of expression are evident. Midline expression begins and is retained throughout embryogenesis in clusters of cells in each segment in the central nervous system. At least some of the midline expression occurs in VUM neurons.
messages: Interacts with Drpr (via extracellular region).
messages: Reduced levels of phagocytosis. Loss of both CaBP1 and Prtp does not cause a further decrease in the reduced level of phagocytosis seen in either CaBP1-lacking or Prtp-lacking embryos.

7227:Dmel CG3504
gene id: 7227:Dmel_CG3504
uniprot id: Q24008
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in rhabdomeres of the compound eyes and ocelli.
messages: Interacts with the C-terminus of trp, and with norpA and inaC to form the inaD signaling complex. Interacts with Fkbp59, which together with trpl, rhodopsin and calmodulin may also be part of the inaD complex.
messages: Involved in the negative feedback regulation of the light-activated signaling cascade in photoreceptors through a calcium-mediated process. Interacts with tetrapeptide ligand located in C-terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex.
messages: Phosphorylated by inaC.
messages: Second PDZ domain is a type I PDZ domain that tethers type I PDZ ligand inaC by interaction with its C-terminus.

7227:Dmel CG6453
gene id: 7227:Dmel_CG6453
uniprot id: Q9VJD1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG12323
gene id: 7227:Dmel_CG12323
uniprot id: Q7K148
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG33090
gene id: 7227:Dmel_CG33090
uniprot id: Q7KT91
uniprot id: X2J9U5
uniprot id: X2JAF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Cell membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide.
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

7227:Dmel CG6074
gene id: 7227:Dmel_CG6074
uniprot id: Q9VB76
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG11760
gene id: 7227:Dmel_CG11760
uniprot id: Q8INQ3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG30169
gene id: 7227:Dmel_CG30169
uniprot id: Q9W157
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates.
messages: Interacts with Rad9 (PubMed:18266476). Interacts with spn-A/Rad51 (PubMed:17822964). Interacts with cyclin CycG (PubMed:22976300).
messages: Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.
messages: Nucleus

7227:Dmel CG6361
gene id: 7227:Dmel_CG6361
uniprot id: A8JUP7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Secreted
messages: Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding.
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
messages: Up-regulated after wounding to the integument. Levels are higher with septic wounding, using either Gram-negative or Gram-positive bacteria.
messages: Viable and fertile with no obvious phenotype. Reduced adult survival after wounding of the thorax, especially when the injury completely penetrates the thorax (strong wound). Wounding coupled with septic infection (septic injury) does not further reduce survival. Survival after wounding is increased when flies ingest the oxidant paraquat. Impaired melanization at the wound site. In pupae, aseptic and septic-injury does not induce the cleavage of PPO1, and in adults and larvae PPO1 activity is abolished.

7227:Dmel CG4792
gene id: 7227:Dmel_CG4792
uniprot id: Q9VCU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination.
messages: Interacts with AGO2 and Fmr1 to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation; other components of the complex are RpL5, RpL11, AGO2 and Rm62 (PubMed:11498593, PubMed:12368261). Interacts with piwi and vas; these interactions occur in the polar granules (PubMed:16949822).

7227:Dmel CG34423
gene id: 7227:Dmel_CG34423
uniprot id: E1JGT3
uniprot id: Q9W1R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mitochondrion

7227:Dmel CG9680
gene id: 7227:Dmel_CG9680
uniprot id: P26802
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
messages: Expressed in the germline tissue of the ovary.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

7227:Dmel CG4046
gene id: 7227:Dmel_CG4046
uniprot id: A0A0B4LG52
uniprot id: Q9W237
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

7227:Dmel CG11154
gene id: 7227:Dmel_CG11154
uniprot id: L0MQ04
uniprot id: Q05825
uniprot id: X2JH42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

7227:Dmel CG1358
gene id: 7227:Dmel_CG1358
uniprot id: Q7K1D7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7952
gene id: 7227:Dmel_CG7952
uniprot id: P39572
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer or heterodimer.
messages: It is uncertain whether Met-1, Met-3, Met-8 or Met-23 is the initiator.
messages: Nucleus
messages: Phosphorylated at multiple sites.
messages: Represses the expression of both the krueppel and knirps segmentation gap genes. Binds, in vitro, to the krueppel regulatory elements CD1 and CD2. It is required in the early embryo for the development of portions of the head and abdomen.

7227:Dmel CG2863
gene id: 7227:Dmel_CG2863
uniprot id: Q9VPR4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NLE1/RSA4 family.
messages: Interacts with Notch (via cytoplasmic domain) (PubMed:9857191). Associates with the pre-60S ribosomal particle (By similarity).
messages: Plays a role in regulating Notch activity.
messages: The name 'Notchless' derives from the ability to suppress the wing notching caused by some Notch mutant alleles.
messages: nucleolus

7227:Dmel CG6958
gene id: 7227:Dmel_CG6958
uniprot id: Q9VCW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup133 family.
messages: Forms part of the Nup107-Nup160 subcomplex in the nuclear pore.
messages: Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance (PubMed:20547758).
messages: nuclear pore complex

7227:Dmel CG13948
gene id: 7227:Dmel_CG13948
uniprot id: M9PAZ2
uniprot id: Q9VPT1
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons. Carbon dioxide-responsive neurons coexpress Gr21a and Gr63a in a pair of chemosensory receptors at both larval and adult life stages. A single bilateral neuron, expressing the Gr21a receptor, is responsible for CO(2) detection in larvae.
messages: Gr21a and Gr63a probably form a heterodimer that responds to CO(2).
messages: Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Impairs CO(2) avoidance of larvae.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The Myb-MuvB complex mediates neuron-specific expression of the carbon dioxide receptor genes Gr63a and Gr21a.

7227:Dmel CG4303
gene id: 7227:Dmel_CG4303
uniprot id: Q9VYG2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subunit
messages: Expressed both maternally and zygotically. Maternal expression is uniform at the blastoderm stage. Zygotic expression becomes predominant at the extended band stage. After germ band retraction, expression is restricted to the ventral nerve chord and the brain.
messages: Involved in the recruitment and site-specific anchoring of the Brahma complex at specific promoter sites (PubMed:16083904, PubMed:24618901). The Brahma complex is a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA (PubMed:16083904, PubMed:24618901). This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (PubMed:16083904). Participates in X-chromosomal dosage compensation (PubMed:16083904). Participates in neurogenesis (PubMed:16083904, PubMed:24618901).
messages: RNAi-mediated knockdown results in ectopic expression of type II neuroblast lineages in larval brains.
messages: There are 2 distinct Brahma complexes in the fruit fly, the Brahma-associated proteins (BAP) and Polybromo-containing BAP (PBAP) complexes, which are composed of common subunits Brm, Mor, Snr1/Bap45, Bap111/Dalo, Bap55, Bap60 and Act42A/Bap47, and additional signature subunits osa in the BAP complex and Polybromo and Bap170 in the PBAP complex (PubMed:15060132). Interacts with sisA and sc (PubMed:16083904). Interacts with mor (PubMed:10809665). Interacts with p53 (PubMed:20308539). Interacts with erm (via N-terminal) (PubMed:24618901). Interacts with akirin; interaction is immune stimulation-dependent; activates selected Rel target gene promoters (PubMed:25180232).

7227:Dmel CG1021
gene id: 7227:Dmel_CG1021
uniprot id: B7Z0W3
uniprot id: E1JJ71
uniprot id: Q9VI21
names: Similarity
messages: Belongs to the TEX28 family.

7227:Dmel CG44296
gene id: 7227:Dmel_CG44296
uniprot id: A0A0B4LF36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG18662
gene id: 7227:Dmel_CG18662
uniprot id: Q9VLG0
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: JanA and janB regulate somatic sex differentiation.

7227:Dmel CG15539
gene id: 7227:Dmel_CG15539
uniprot id: A0A0B4LHW6
uniprot id: Q0KHY7
uniprot id: Q4V443
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG43776
gene id: 7227:Dmel_CG43776
uniprot id: A0A0B4KFH2
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG2380
gene id: 7227:Dmel_CG2380
uniprot id: L0MPW8
uniprot id: Q86P06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTF/NF-I family.
messages: Nucleus

7227:Dmel CG5626
gene id: 7227:Dmel_CG5626
uniprot id: Q9VTV4
names: Similarity
messages: Belongs to the SEN54 family.

7227:Dmel CG10117
gene id: 7227:Dmel_CG10117
uniprot id: A0A0B4KER9
uniprot id: D5SHU8
uniprot id: Q9V730
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Tout velu' means 'very hairy' in French.
messages: According to some authors (PubMed:10549295) ttv mutants have no effect on wg signaling, while according to others (PubMed:14645127, PubMed:14729575 and PubMed:15056609) wg signaling is affected. Such discrepancy may be explained by the fact that the absence of ttv could be partially compensated by the intact sotv protein.
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically.
messages: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, dpp and wg morphogens.
messages: Golgi apparatus membrane
messages: Interacts with sau (PubMed:23720043).
messages: Ubiquitously expressed in early embryos. Later (in stage 10 embryos), it is expressed at higher level in the nervous system. Ubiquitously expressed in wing imaginal disk.

7227:Dmel CG42310
gene id: 7227:Dmel_CG42310
uniprot id: A0A0B4LGM0
uniprot id: A0AVW1
uniprot id: B7YZQ3
uniprot id: Q8MLN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane

7227:Dmel CG8824
gene id: 7227:Dmel_CG8824
uniprot id: A0A0B4LF89
uniprot id: A0A0B4LG91
uniprot id: Q8WSF3
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 20 family.
messages: In third instar larval and early pupal brains, expressed in cells sending projections across the interhemispheric junction. In adult brain, expressed in mushroom body, ellipsoid body and pars intercerebralis.
messages: Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing.

7227:Dmel CG2969
gene id: 7227:Dmel_CG2969
uniprot id: A2RVF0
uniprot id: Q9VQY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG31013
gene id: 7227:Dmel_CG31013
uniprot id: Q9VA50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG15395
gene id: 7227:Dmel_CG15395
uniprot id: Q7KU18
names: Similarity
messages: Belongs to the TPX2 family.

7227:Dmel CG7589
gene id: 7227:Dmel_CG7589
uniprot id: Q9VVH4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG11761
gene id: 7227:Dmel_CG11761
uniprot id: Q7JVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

7227:Dmel CG10371
gene id: 7227:Dmel_CG10371
uniprot id: Q86BN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Highly enriched in testis.
messages: Lipid phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Protein phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Does not dephosphorylate Akt.
messages: Mitochondrion inner membrane

7227:Dmel CG14472
gene id: 7227:Dmel_CG14472
uniprot id: M9PB68
uniprot id: Q9VLT5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the UBR4 family.
messages: Expressed in embryonic central nervous system and adult testes.
messages: Flies increase the growth of the perineurial glial layer of the larval peripheral nerve and exhibit male sterility due to the inhibition of sperm individualization.
messages: Has a role in growth of the perineurial glial layer of the larval peripheral nerve (PubMed:27552662). May have a role in male fertility and eye development or function (PubMed:27552662). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662).
messages: May bind calmodulin (PubMed:9813038). Interacts with Kcmf1 (PubMed:27552662).

7227:Dmel CG6919
gene id: 7227:Dmel_CG6919
uniprot id: E1JIT6
uniprot id: Q9VCZ3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037). Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037). Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037).
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in adult, pupae, third instar larvae, and 0-4 hour and 0-18 hour old embryos (PubMed:15816867, PubMed:22303848). Levels increase significantly at the late embryonic stage, gradually decrease during postembryonic development and increase slightly in the adult (PubMed:22303848).
messages: Fails to respond to starvation by increasing locomotor activity. Decreased basal levels of locomotion. Overgrowth of octopaminergic and glutamatergic (type I and type II) neuromuscular junctions. Increase in the number of terminal type I and type II boutons and in the motile filopodia-like extensions (synaptopods) which form during the expansion of type II terminals in developing larvae.
messages: In the adult, expressed in the superior protocerebrum and the optic lobe medulla of the central nervous system, nurse cells of egg chambers in the ovary at oogenic stages 1-10, and spermatogonia and spermatocytes in the testis (PubMed:22303848). Expressed in embryonic and larval ventral nerve cord and brain lobe, and the larval imaginal disk and larval salivary gland (PubMed:22303848). Also expressed in larval synaptic boutons and retinal cells in the optic disk (PubMed:22553037).
messages: Membrane

7227:Dmel CG12473
gene id: 7227:Dmel_CG12473
uniprot id: Q24212
uniprot id: X2JCY4
uniprot id: X2JGF5
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: Interacts with the second C2 domain of Syt.
messages: Partially edited.
messages: Present at synaptic connections both in the CNS and in neuromuscular junctions in the mature embryo (20-22h) and throughout larval development. In the third instar larva, it is expressed in all synaptic bouton types, including I, II and III boutons.
messages: StnA, which is involved in the same pathway, is derived from the same bicistronic transcript that encodes these two different proteins.
messages: Synapse
messages: The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, are known to interact with the EH domain.

7227:Dmel CG5325
gene id: 7227:Dmel_CG5325
uniprot id: Q8IP97
names: Similarity
messages: Belongs to the peroxin-19 family.

7227:Dmel CG15144
gene id: 7227:Dmel_CG15144
uniprot id: Q9VJC4
names: Similarity
messages: Belongs to the CFAP91 family.

7227:Dmel CG8019
gene id: 7227:Dmel_CG8019
uniprot id: B7Z0G1
uniprot id: Q02870
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of haywire/XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Belongs to the helicase family. RAD25/XPB subfamily.
messages: Component of the 7-subunit TFIIH core complex composed of haywire/XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. Interacts with ATF7IP. Interacts with Epstein-Barr virus EBNA2.
messages: Nucleus

7227:Dmel CG15629
gene id: 7227:Dmel_CG15629
uniprot id: Q9VR28
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG12026
gene id: 7227:Dmel_CG12026
uniprot id: Q9W068
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11354
gene id: 7227:Dmel_CG11354
uniprot id: M9PJE4
uniprot id: Q9V472
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG6382
gene id: 7227:Dmel_CG6382
uniprot id: M9PD08
uniprot id: Q9VK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

7227:Dmel CG7314
gene id: 7227:Dmel_CG7314
uniprot id: Q7K566
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Expressed throughout development. Expression levels are very weak, but increase in the adult stages.
messages: Expression levels are higher in the head than the body.
messages: Functions as a mitochondrial uncoupling protein when expressed in yeast.
messages: Mitochondrion inner membrane
messages: No visible phenotype. Reduced levels of total sugars (glucose and trehalose) in normal-fed flies and increased susceptibility to starvation. Life span is increased when fed a low-calorie diet and flies gain less weight when fed a high-calorie diet. Females lay a lower proportion of eggs, particularly under a restricted diet. Glycogen and triacylglyceride (TAG) levels are not affected in normal-fed flies. However, TAG levels decrease at a faster rate under starvation conditions. No increase in life span when fed a high-calorie diet or under starvation conditions.
messages: Regulates metabolic homeostasis in response to nutritional cues and may therefore be involved in adaptation to dietary variations. May not function in creating mitochondrial proton leaks across the inner mitochondrial membrane (i.e. mitochondrial uncoupling).

7227:Dmel CG7104
gene id: 7227:Dmel_CG7104
uniprot id: Q9VLV7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subunit
messages: 'Spaetzle' means 'noodles' in German.
messages: Expressed in larval muscles.
messages: Homodimer; disulfide-linked.
messages: Neurotrophin which may function as a ligand to the Toll-related receptor Tollo. Involved in a Tollo and JNK signaling pathway that positively regulates neuromuscular junction (NMJ) growth in presynaptic motorneurons. May function by activating Tollo to promote the phosphorylation of JNK.
messages: RNAi-mediated knockdown has no effect on neuromuscular junction (NMJ) growth. However, conditional knockdown in the muscles results in a decrease in bouton number at the NMJs.

7227:Dmel CG4729
gene id: 7227:Dmel_CG4729
uniprot id: D5AEK7
uniprot id: Q9VV51
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

7227:Dmel CG7629
gene id: 7227:Dmel_CG7629
uniprot id: Q9VEH5
names: Similarity
messages: Belongs to the attacin/sarcotoxin-2 family.

7227:Dmel CG1796
gene id: 7227:Dmel_CG1796
uniprot id: Q9VYQ9
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

7227:Dmel CG1618
gene id: 7227:Dmel_CG1618
uniprot id: M9PH10
uniprot id: P46461
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Nervous system.
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

7227:Dmel CG5583
gene id: 7227:Dmel_CG5583
uniprot id: A0A0B4LHS8
uniprot id: B7FNJ4
uniprot id: P29775
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Expressed throughout development with lower levels during larval development.
messages: May have a role in germline development.
messages: Nucleus
messages: Transient high expression in pole cells during embryonic stages 8-11.

7227:Dmel CG5722
gene id: 7227:Dmel_CG5722
uniprot id: Q9VL24
uniprot id: X2J9B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7227:Dmel CG11110
gene id: 7227:Dmel_CG11110
uniprot id: Q4QQ12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG33286
gene id: 7227:Dmel_CG33286
uniprot id: Q7KTX4
names: Similarity
messages: Belongs to the DNAI7 family.

7227:Dmel CG42237
gene id: 7227:Dmel_CG42237
uniprot id: Q9VYG9
uniprot id: X2JBI9
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG30048
gene id: 7227:Dmel_CG30048
uniprot id: A1Z8Y9
uniprot id: A1Z8Z0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG5755
gene id: 7227:Dmel_CG5755
uniprot id: Q9VJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG4103
gene id: 7227:Dmel_CG4103
uniprot id: Q9V3N8
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

7227:Dmel CG14672
gene id: 7227:Dmel_CG14672
uniprot id: A0A1B2AJ56
uniprot id: Q9VNE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

7227:Dmel CG9801
gene id: 7227:Dmel_CG9801
uniprot id: Q0KIA2
names: RNA Editing
messages: Partially edited. Target of Adar.

7227:Dmel CG4574
gene id: 7227:Dmel_CG4574
uniprot id: P25455
names: Function
names: Tissue Specificity
messages: Expressed in neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia in adults, and the brain of larvae.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

7227:Dmel CG3028
gene id: 7227:Dmel_CG3028
uniprot id: Q9VFP6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG42641
gene id: 7227:Dmel_CG42641
uniprot id: M9PG62
uniprot id: P25161
names: Caution
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S3 family.
messages: Blood (crystal) cells and cuticle.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).
messages: Was originally thought to be the diphenol oxidase A2 component involved in catecholamine metabolism, melanin formation, and sclerotization of the cuticle.

7227:Dmel CG8595
gene id: 7227:Dmel_CG8595
uniprot id: Q7KIN0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Toll-like receptor family.
messages: Cell membrane
messages: Expressed in the fan-shaped body and the ellipsoid body, which are components of the locomotion center in the CNS (at protein level) (PubMed:23892553).
messages: In embryos, expressed in the ventral neurons, motor neurons and in the longitudinal interneuron axons (at protein level) (PubMed:23892553). May also be expressed in the motor neuron dendrites or possibly the glia (at protein level) (PubMed:23892553). Expressed 48 hours after puparium formation in the lateral glomeruli of the anterior and central regions of the antennal lobe, including the DA1, VA1d and VA1v glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At germ band extension, expressed as 14 stripes in the embryo (PubMed:12617819). At germ band retraction, expressed in a subset of neurons in the CNS, the precursors of the leg imaginal disks and in the ventral epithelium of the large intestine (PubMed:12617819). Expressed in the posterior and anterior spiracles (PubMed:12617819). In stage 16 embryos, expression decreases and is mainly localized to the CNS (PubMed:12617819). Expressed in the proximal region of the wing imaginal disks, around the wing pouch and hinge regions (PubMed:21158756). Also expressed in the distal segments of the leg imaginal disks, with high levels of expression around the A-P border of the tarsal to tibia segments (PubMed:21158756). In larvae, detected in the fat body (PubMed:12617819).
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Mistargeting of VA1d ORN axons to a medial position (PubMed:25741726). No effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). RNAi-mediated knockdown results in adults that are acutely sensitive to the vesicular stomatitis virus (vsv) (PubMed:22464169). Following infection with vsv adult survival is decreased, and adults show a dramatic increase in viral RNA production 6 days post vsv infection and viral replication 9 days post infection (PubMed:22464169). Reduced autophagy in adult fat body cells following vsv infection (PubMed:22464169). Starvation-induced autophagy is not affected (PubMed:22464169).
messages: Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
messages: Up-regulated during vesicular stomatitis virus (VSV) infection.

7227:Dmel CG31366
gene id: 7227:Dmel_CG31366
uniprot id: P02825
uniprot id: P82910
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Forms a complex with Hsp83 and Dpit47.
messages: Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
messages: There are two copies of the gene coding for this protein at chromosome locus 87A7.

7227:Dmel CG4567
gene id: 7227:Dmel_CG4567
uniprot id: Q9VM33
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Larvae are able to survive on maternal contribution until the third larval stage but they fail to initiate the rapid growth phase and die.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Essential during development as it acts as a retrograde signal from mitochondria to the nucleus to slow down cell proliferation if mitochondrial energy output is low.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7227:Dmel CG17528
gene id: 7227:Dmel_CG17528
uniprot id: Q7PLI7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7227:Dmel CG3922
gene id: 7227:Dmel_CG3922
uniprot id: P17704
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

7227:Dmel CG40305
gene id: 7227:Dmel_CG40305
uniprot id: P83088
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7227:Dmel CG8827
gene id: 7227:Dmel_CG8827
uniprot id: Q10714
uniprot id: X2J8C3
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed in the amnioserosa during germ band elongation, shortening and heart morphogenesis. Expressed in midgut throughout embryogenesis.
messages: Expressed in vesicular structures in spermatocytes and early spermatids (at protein level).
messages: Glycosylated.
messages: Inhibited by captopril and, to a lesser extent, by lisinopril, trandolaprilat, fosinoprilat and enalaprilat.
messages: Male flies are sterile.
messages: May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.
messages: extracellular space

7227:Dmel CG4546
gene id: 7227:Dmel_CG4546
uniprot id: Q9VF23
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG31196
gene id: 7227:Dmel_CG31196
uniprot id: C6TP70
uniprot id: P92177
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer (By similarity). Interacts with phosphorylated yki (PubMed:18256197, PubMed:19900439). Interacts with pav (when serine phosphorylated); the interaction is necessary for association of the complex pav-14-3-3epsilon complex to the microtubules, thereby inhibiting microtubule sliding (PubMed:32022690).
messages: Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization. Together with pav, has a role in the inhibition of microtubule sliding during neurite outgrowth (PubMed:32022690).

7227:Dmel CG10131
gene id: 7227:Dmel_CG10131
uniprot id: Q5U1B0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

7227:Dmel CG3167
gene id: 7227:Dmel_CG3167
uniprot id: Q7JRE4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: High levels of expression in eggs and first instar larvae (at protein level) (PubMed:16439308). Levels decline between the second and third instar stages, and then increase during the pupal to adult stages (at protein level) (PubMed:16439308). Expressed in the pupal and larval wing (PubMed:20036230). In pupal wings, expression appears to be enhanced in the presumptive longitudinal veins (PubMed:20036230).
messages: Inner nuclear membrane protein (PubMed:16439308). Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ) (PubMed:18723885, PubMed:20036230). Appears to be required for pupal development and consequently transition to the adult stage (PubMed:18723885, PubMed:20036230). During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote (PubMed:24700158).
messages: Interacts with Lam and LamC (PubMed:16439308). Interacts with Mad (PubMed:20036230). Interacts (via N-terminus) with baf (PubMed:20036230).
messages: Loss of maternal and zygotic activity results in a reduction in survival at each developmental stage, with mutants rarely surviving to the adult stage (PubMed:18723885). Adult escapers display held out wings and exhibit wing patterning defects with thickened longitudinal veins, a varied number of anterior crossveins, branched posterior crossvein and folded wing blades (PubMed:18723885). In adults, climbing is impaired and their climbing ability further decreases with age (PubMed:18723885). Males are sterile and females display reduced fecundity (PubMed:18723885). No significant decrease in adult survival, however double mutants with either Ote or bocks do not survive to the adult stage (PubMed:24700158). No effect on nuclear envelope formation (PubMed:18723885). Larval brain size and imaginal disks are normal in double mutants with either Ote or bocks (PubMed:24700158).
messages: Nucleus inner membrane
messages: nucleoplasm
messages: spindle pole

7227:Dmel CG4460
gene id: 7227:Dmel_CG4460
uniprot id: P02515
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG7121
gene id: 7227:Dmel_CG7121
uniprot id: Q9VJX9
names: Similarity
messages: Belongs to the Toll-like receptor family.

7227:Dmel CG9962
gene id: 7227:Dmel_CG9962
uniprot id: Q9VQE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG42304
gene id: 7227:Dmel_CG42304
uniprot id: Q9VZY7
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8783
gene id: 7227:Dmel_CG8783
uniprot id: B6IDY8
uniprot id: Q9VUB4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A high percentage of mutants die as pupae or pharate adults (PubMed:27166823, PubMed:27672113). Under nutrient-replete conditions, larvae display a significant increase in TORC1 activity (PubMed:27672113, PubMed:27166823). Adult escapers display a small but significant increase in body weight and a reduction in climbing (PubMed:27672113). Newly hatched males have a decreased tolerance to both complete starvation and amino acid starvation, likely due to decreased triacylglyceride (TAG) storage and the inability to down-regulate TORC1 activity and activate catabolic metabolism and autophagy (PubMed:27672113). Conditional RNAi-mediated knockdown in the female germline results in a small decrease in the rate of egg production when females are provided with a protein source of wet yeast (PubMed:24786828). Females starved of amino acids for a brief period have increased numbers of degenerating young eggs and show permanent loss of fertility (PubMed:24786828). Mid-stage egg chambers are unaffected (PubMed:24786828).
messages: An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823, PubMed:25512509). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823, PubMed:25512509). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823). In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:27672113, PubMed:25512509). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509).
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823). Interacts with Nprl2 (PubMed:24786828).
messages: Cytoplasm
messages: Lysosome

7227:Dmel CG5520
gene id: 7227:Dmel_CG5520
uniprot id: Q9VAY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm

7227:Dmel CG14271
gene id: 7227:Dmel_CG14271
uniprot id: Q8MT08
uniprot id: X2JCG2
uniprot id: X2JI73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: Cytoskeletal linker which probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity).
messages: cytoskeleton
messages: flagellum basal body

7227:Dmel CG7872
gene id: 7227:Dmel_CG7872
uniprot id: Q9VXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

7227:Dmel CG5876
gene id: 7227:Dmel_CG5876
uniprot id: Q9V3R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Mitochondrion membrane
messages: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption.

7227:Dmel CG14013
gene id: 7227:Dmel_CG14013
uniprot id: Q9VMP6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

7227:Dmel CG9947
gene id: 7227:Dmel_CG9947
uniprot id: Q9VXG0
uniprot id: X2JKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

7227:Dmel CG1803
gene id: 7227:Dmel_CG1803
uniprot id: Q76NR6
uniprot id: Q9VYR1
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.

7227:Dmel CG11857
gene id: 7227:Dmel_CG11857
uniprot id: A0A140SRF8
uniprot id: Q9VBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

7227:Dmel CG41378
gene id: 7227:Dmel_CG41378
uniprot id: A0A0C4DHM7
uniprot id: A0A0C4DHN1
uniprot id: A0A0C4DHN2
uniprot id: A0A0C4DHN6
names: Similarity
messages: Belongs to the GILT family.

7227:Dmel CG1844
gene id: 7227:Dmel_CG1844
uniprot id: Q7Z2C4
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in larvae and adults but strongest expression is found in embryos, within syncytial blastoderm, cellular blastoderm and gastrulation stages.
messages: Golgi apparatus membrane
messages: Plays a role in the life span. May be involved in regulating the redox state of the cell and possesses anticarcinogenic properties.

7227:Dmel CG11888
gene id: 7227:Dmel_CG11888
uniprot id: A0A0B4KHE9
uniprot id: A0A0B4KI10
uniprot id: Q9V3P6
names: Function
names: Similarity
names: Subunit
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

7227:Dmel CG2789
gene id: 7227:Dmel_CG2789
uniprot id: Q9VPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

7227:Dmel CG5933
gene id: 7227:Dmel_CG5933
uniprot id: Q9VCE6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MT-A70-like family.
messages: Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:27919081, PubMed:28675155). In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:27919081, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077). During oogenesis, required for egg chamber development probably as part of the N/Notch signaling (PubMed:21873203).
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:28675155, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:28675155, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:29535189, PubMed:29555755).
messages: Expressed in testes (PubMed:21873203). In the ovaries, detected in germaria, prefollicle, follicle and polar cells (at protein levels) (PubMed:21873203). Detected in the ooplasm and in the cells of the 16-cell cyst of early stages (at protein levels) (PubMed:21873203).
messages: Flies have a reduced lifespan and exhibit multiple behavioral defects: flight and locomotion are severely affected and they spend more time grooming (PubMed:27919077, PubMed:27919081, PubMed:28675155). They also display a mild held-out wing appearance resulting from failure to fold their wings together over the dorsal surface of the thorax and abdomen (PubMed:27919077, PubMed:28675155). RNAi-mediated knockdown results in semi lethality and reduced fertility due to the presence of compound egg chambers with supernumerary nurse cells in the ovaries (PubMed:21873203).
messages: Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
messages: Nucleus
messages: Ubiquitously expressed in early embryonic stages with enrichment in the neuroectoderm at later stages.

7227:Dmel CG34147
gene id: 7227:Dmel_CG34147
uniprot id: Q0E959
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG9792
gene id: 7227:Dmel_CG9792
uniprot id: Q9VFV1
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG8176
gene id: 7227:Dmel_CG8176
uniprot id: A0A0B4KFZ2
uniprot id: Q6AWD5
uniprot id: Q9VHC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

7227:Dmel CG7882
gene id: 7227:Dmel_CG7882
uniprot id: Q0IGX4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7227:Dmel CG33200
gene id: 7227:Dmel_CG33200
uniprot id: Q9N2P6
names: Developmental Stage
names: Tissue Specificity
messages: Expressed in ventral cells of the blastoderm and/or in cells of ventral origin. The sharp lateral boundaries overlap with snail (sna) expression.
messages: Not expressed after germ-band retraction.

7227:Dmel CG3945
gene id: 7227:Dmel_CG3945
uniprot id: A8JNV5
uniprot id: O96533
names: Similarity
messages: Belongs to the rad9 family.

7227:Dmel CG1088
gene id: 7227:Dmel_CG1088
uniprot id: A0A0B4LGS4
uniprot id: P54611
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase E subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

7227:Dmel CG17224
gene id: 7227:Dmel_CG17224
uniprot id: Q0E8U4
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

7227:Dmel CG10143
gene id: 7227:Dmel_CG10143
uniprot id: Q7KGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7227:Dmel CG10908
gene id: 7227:Dmel_CG10908
uniprot id: M9PBP5
uniprot id: Q9VQ57
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
messages: Membrane

7227:Dmel CG8745
gene id: 7227:Dmel_CG8745
uniprot id: Q9VU95
names: Caution
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Does not seem to possess aminotransferase activity.

7227:Dmel CG14039
gene id: 7227:Dmel_CG14039
uniprot id: Q9VMU5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Tissue Specificity
messages: Adult males appear unable to discriminate between males and females when choosing a mate; either because they display increased levels of courtship behavior towards males (when presented with only males) or they display the same levels of courtship towards both males and females (when presented with both sexes) (PubMed:10747058, PubMed:22292044). During male-female courtship, they also begin courting virgin females earlier than wild-type males, suggesting that their increased tendency to court both sexes may also be due to an increase in male sexual activity (PubMed:10747058). No effect on female sexual behavior, and other aspects of male sexual behavior appear unaffected (PubMed:10747058). RNAi-mediated knockdown in neurons of adult males abolishes their ability to discriminate between male and female during courtship (PubMed:22292044). RNAi-mediated knockdown in the mushroom bodies of adult males, results in a slight, but not significant, decrease in their ability to discriminate between males and females (PubMed:22292044). Howver, RNAi-mediated knockdown in various chemosensory peripheral neurons have no effect on male sex discrimination (PubMed:22292044).
messages: Detected in embryos, adult males and females.
messages: Expressed in the third antennal segment and the maxillary palp, with increased expression near the cuticle of both olfactory organs (PubMed:10747058). Also detected in the second antenna segment (PubMed:10747058). In the brain, expressed in the central nervous system, with high levels of expression in the visual system including the retina and optic lobe, and uniform expression in the cortex (PubMed:10747058). Detected in the thorax and abdomen, with increased expression in the ventral ganglion (PubMed:10747058). In males, detected in the reproductive tract including the ejaculatory bulb and testis (PubMed:10747058).
messages: In adult males, modulates sexual behavior by playing a role in sex discrimination and maintaining normal levels of sexual activity towards both males and females.
messages: The name 'quick-to-court' derives from mutant males being quick to initiate courtship of both females and males.

7227:Dmel CG1543
gene id: 7227:Dmel_CG1543
uniprot id: Q86B61
uniprot id: X2JIW9
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At larval stage, present in cell bodies of the ventral ganglion and in neuropil (at protein level).
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion (PubMed:14623230, PubMed:14978721, PubMed:8656284). Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity (PubMed:23142736).
messages: Flies survive to adulthood. Mutant males are fertile, but mutant females are sterile due to defects in ovulation.
messages: Membrane
messages: Present in head and in neurons innervating the oviduct (at protein level).
messages: Slightly down-regulated in adults fed a high calorie diet.

7227:Dmel CG9565
gene id: 7227:Dmel_CG9565
uniprot id: Q9W5Y0
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: In embryos, expressed in the central nervous system from stages 14 to 17. In third-instar larvae, expressed in the brain, ventral ganglion and midgut.
messages: Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle-term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation.
messages: RNAi-mediated knockdown in the dorsal paired medial neurons impairs middle-term (MTM) and long-term memory (LTM), but has no effect on normal aversion learning and anesthesia-resistant memory (ARM) (PubMed:27629706). RNAi-mediated knockdown in all mushroom body neurons has no effect on learning, ARM and LTM (PubMed:27629706). However, simultaneous knockdown with Nep2 or Nep4 does impair LTM, and simultaneous knockdown with both Nep2 and Nep4 results in a further reduction in LTM formation (PubMed:27629706). Wild-type females mated to males that undergo RNAi-mediated knockdown, lay the same number of eggs and have a similar hatch rate to those mated to wild-type males (PubMed:24395329).

7227:Dmel CG1848
gene id: 7227:Dmel_CG1848
uniprot id: A0A650FBE4
uniprot id: E1JJM7
uniprot id: Q8IR79
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Expressed from early third instar to late pupal stages.
messages: Expressed throughout the imaginal disks of the eye, leg and wing.
messages: Interacts with LATS1, and this interaction inhibits phosphorylation of tsr/cofilin.
messages: Midbody
messages: Phosphorylated on serine and/or threonine residues by ROCK1. Phosphorylated by PAK4 resulting in increased LIMK1 ability to phosphorylate cofilin. May be dephosphorylated and inactivated by SSH1 (By similarity).
messages: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.

7227:Dmel CG1559
gene id: 7227:Dmel_CG1559
uniprot id: Q9VYS3
uniprot id: X2JBC1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: In Drosophila, the definition of premature stop codons in mRNAs appears to be independent of exon boundaries and of the EJC complex.
messages: Phosphorylated, probably by nonC.
messages: RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity).

7227:Dmel CG5972
gene id: 7227:Dmel_CG5972
uniprot id: Q9VMH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

7227:Dmel CG9987
gene id: 7227:Dmel_CG9987
uniprot id: Q9VIW7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

7227:Dmel CG44098
gene id: 7227:Dmel_CG44098
uniprot id: A0A0B4KF18
uniprot id: D2NUL5
uniprot id: Q9VN52
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10704
gene id: 7227:Dmel_CG10704
uniprot id: M9PFA4
uniprot id: Q8T0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

7227:Dmel CG7225
gene id: 7227:Dmel_CG7225
uniprot id: A0A0B4LGZ1
uniprot id: O44342
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Windbeutel' means 'profiteroles' in German.
messages: Briefly expressed in the follicle cells of the ovary, at around the time when the dorsoventral axis of the egg chamber is first established.
messages: Endoplasmic reticulum lumen
messages: Expressed in ovaries, early embryo (0-4 hours) and adult males. Almost undetectable in female carcasses. In ovaries, it is not detected in the germarium or early stage egg-chambers and is first detectable in the follicle cells of stage 8 egg-chambers. The peak of expression occurs in the follicle cells of stages 9 and early 10, and it disappears completely before stage 11. Not expressed in the germline cells (nurse cells and oocyte), with the possible exception of late stage 10 nurse cells.
messages: Homodimer.
messages: Homodimer. Interacts directly with pip.
messages: Probable chaperone protein involved in dorsoventral axis patterning in early embryos. Probably acts by folding and targeting pipe (pip) into the Golgi.
messages: The CXXC motif was initially thought to constitute the active site of a potential protein disulfide isomerase activity. However, such motif is not essential, suggesting that it has no disulfide isomerase activity. Its precise role remains unclear.

7227:Dmel CG9474
gene id: 7227:Dmel_CG9474
uniprot id: Q9VH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

7227:Dmel CG9703
gene id: 7227:Dmel_CG9703
uniprot id: O97132
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG15148
gene id: 7227:Dmel_CG15148
uniprot id: Q0E8P6
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG18258
gene id: 7227:Dmel_CG18258
uniprot id: Q9VX70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG13874
gene id: 7227:Dmel_CG13874
uniprot id: Q9V8Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PBP/GOBP family.
messages: Expressed in both gustatory and olfactory systems of larvae and adults. Expressed in antenna, proboscis and larval chemosensory organ. Expressed in five sensilla on each third antennal segment, in the pharyngeal organs and in the dorsal organ, terminal organ and the ventral pits of the third instar larvae. Also expressed in wing and tarsi.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid (By similarity). May function in both olfactory and gustatory systems.
messages: Secreted

7227:Dmel CG33813
gene id: 7227:Dmel_CG33813
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG10325
gene id: 7227:Dmel_CG10325
uniprot id: E1JIM9
uniprot id: P29555
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed by Abd-B only in the eight and ninth abdominal segments.

7227:Dmel CG4875
gene id: 7227:Dmel_CG4875
uniprot id: Q9VX99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

7227:Dmel CG2903
gene id: 7227:Dmel_CG2903
uniprot id: B7FNJ7
uniprot id: C9QP23
uniprot id: Q960X8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
messages: Expressed both maternally and zygotically throughout development.
messages: Homodimer; in vitro. Interacts with ubiquitin.
messages: cell cortex
messages: perinuclear region

7227:Dmel CG7380
gene id: 7227:Dmel_CG7380
uniprot id: M9PCH8
uniprot id: Q9VLU0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BAF family.
messages: Chromosome
messages: Cytoplasm
messages: Death at the larval-pupal transition with small brains and missing imaginal disks. Specific abnormalities in interphase nuclear structure; clumping of chromatin and convolution of nuclear shape.
messages: May interact with MAD1.
messages: Nucleus
messages: Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle.

7227:Dmel CG2650
gene id: 7227:Dmel_CG2650
uniprot id: O76879
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Abundantly expressed during pupation and decreases rapidly with age. Expression is under pupal (eclosion) circadian clock control.
messages: Belongs to the TO family.
messages: Component of the circadian clock or downstream effector of clock function (PubMed:2517256, PubMed:31080079). Required for suppressing daytime sleep (siesta) under ambient environmental temperatures. Part of a heat avoidance mechanism that modulates daytime sleep behavior under different environmental temperatures to minimize the risk of heat exposure. Under cooler ambient temperatures, suppresses daytime sleep (siesta) and thus allows for longer periods of daytime activity (PubMed:31080079).
messages: Epidermis of newly eclosed adults.
messages: Expression is under the control of a thermosensitive enhancer element called dmpi8 that is encoded in an intron of the close-by circadian clock gene per. At lower temperatures, splicing efficiency of dmpi8 is increased resulting in an increase in the expression of dyw.
messages: Named 'daywake' based upon its function in daytime sleep suppression.
messages: RNAi-mediated knockdown in per-expressing cells increases daytime sleep levels whereas night-time sleep levels are relatively unaffected.

7227:Dmel CG12048
gene id: 7227:Dmel_CG12048
uniprot id: A0A0B4KHH4
uniprot id: Q9VAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG4486
gene id: 7227:Dmel_CG4486
uniprot id: Q9V4I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG5805
gene id: 7227:Dmel_CG5805
uniprot id: Q9VC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG5122
gene id: 7227:Dmel_CG5122
uniprot id: Q9VK40
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7227:Dmel CG15735
gene id: 7227:Dmel_CG15735
uniprot id: Q9VYR0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LSM12 family.
messages: Component of the Atx2-tyf activator complex which functions in the circadian pacemaker neurons to activate the TYF-dependent translation of per and maintain 24 hour periodicity in circadian behaviors. Within the Atx2-tyf complex, likely to function as a molecular adapter which stabilizes the interaction between Atx2 and the translational regulator tyf.
messages: Component of the Atx2-tyf activator complex, composed of Atx2, tyf, pAbp, Lsm12. Interacts with tyf, Atx2 and pAbp.
messages: RNAi-mediated knockdown in pigment dispersing factor (Pdf)-expressing clock neurons disrupts circadian locomotor rhythms, with mutants displaying long period locomotor rhythms under constant dark conditions. Enhances the period-lengthening phenotype of tyf mutants.

7227:Dmel CG10877
gene id: 7227:Dmel_CG10877
uniprot id: Q9VDL4
names: Similarity
messages: Belongs to the CoA-transferase III family.

7227:Dmel CG32064
gene id: 7227:Dmel_CG32064
uniprot id: Q95R35
names: Similarity
messages: Belongs to the peptidase M17 family.

7227:Dmel CG7533
gene id: 7227:Dmel_CG7533
uniprot id: Q9VTI8
uniprot id: X2JAZ6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DDIT4 family.
messages: Cytoplasm
messages: Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and mildly by hypoxia in midgut but not fat body.
messages: Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells.
messages: Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development.

7227:Dmel CG1056
gene id: 7227:Dmel_CG1056
uniprot id: A8JQT4
uniprot id: E1JJ46
uniprot id: Q6AWQ4
uniprot id: Q8IPN2
uniprot id: Q9VN38
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG9539
gene id: 7227:Dmel_CG9539
uniprot id: Q8STG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

7227:Dmel CG3469
gene id: 7227:Dmel_CG3469
uniprot id: M9PEL6
uniprot id: Q24173
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

7227:Dmel CG42387
gene id: 7227:Dmel_CG42387
uniprot id: A3RLR1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: At early stages of embryogenesis, the polycistronic RNA is expressed in seven segmentally separated blastoderm stripes and in a cluster of cells in the anterior part of the embryo (PubMed:17439302). By stage 13 to the end of embryo development, it is expressed in the dorsal trunks, posterior spiracles, pharynx, hindgut and the area which forms the denticle belts (PubMed:17439302). In the leg disk, it is expressed in a ring pattern presumed to be developing tarsal region around 80 to 96 h after egg laying (AEL) and then in the tarsal furrow at the mid-third instar larval stage (PubMed:17439302, PubMed:18801356). Not detected in the tarsal primordium after 100h AEL but is still expressed in a dorsal chordotonal organ of the leg disk (PubMed:17439302). In pupae, expressed broadly throughout the leg disk 0-3 h after puparium formation (APF) but is not detected in this region 6h APF (PubMed:25344753). High expression 4-8 h APF in the presumptive joints between tarsal segments (PubMed:21682860). In the noctum expressed from 40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae, expressed in two anterior stripes and later in the precursors for chemosensory organs (PubMed:21682860). From late third stage instar larvae to early pupal stages, it is also expressed in the wing provein cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In eye disks, expressed in preclusters for presumptive R8 photoreceptors and in a stripe of cells in the posterior region of the disk (PubMed:21682860).
messages: Cytoplasm
messages: Nucleus
messages: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114).
messages: Polycistronic RNA up-regulated by ecdysone.
messages: Simultaneous knockout of tal-1A, tal-2A, tal-3A and tal-AA is embryonic lethal (PubMed:17439302, PubMed:17486114). In embryos chitin secretion and formation of the cuticular exoskeleton appears to be normal (PubMed:17439302, PubMed:17486114). However embryos display a loss of denticle belts and dorsal hairs (PubMed:17439302, PubMed:17486114). Segment-specific epidermal sensory organs are present and segments form normally (PubMed:17439302). The cephalopharyngeal skeleton is lost, and the head skeleton and posterior spiracles are deformed (PubMed:17439302). In the developing leg, tarsal constriction occurs but the tarsal fold does not form (PubMed:17439302). The tracheal system is abnormal displaying a loss of network integrity, an irregular tube diameter and the absence of taenidial folds (PubMed:17439302, PubMed:17486114). Cell packing is not affected, but there is no accumulation of F-actin at the sites of denticle differentiation or formation of F-actin bundles during taenidial development and tracheal tube dilation (stages 14 and 16) (PubMed:17486114). Other F-actin based developmental processes such as filopodia formation of tracheal tip cells, dorsal closure, mitosis or tight packing of denticle cells are unaffected (PubMed:17486114). Denticle and tracheal defects can be rescued by ectopic expression of any one of the four tal peptides (tal-1A, tal-2A, tal-3A and tal-AA) (PubMed:17486114).
messages: This protein is produced by a polycistronic gene which also produces tal-1A, tal-2A and tal-3A from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).

7227:Dmel CG6276
gene id: 7227:Dmel_CG6276
uniprot id: Q9VF93
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG33827
gene id: 7227:Dmel_CG33827
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG10610
gene id: 7227:Dmel_CG10610
uniprot id: B6IDJ7
uniprot id: Q9U6M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Interacts with Traf6.
messages: Involved in the innate immune response. Promotes the production of antibacterial peptides.
messages: Mitochondrion
messages: Nucleus
messages: Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

7227:Dmel CG33841
gene id: 7227:Dmel_CG33841
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG3071
gene id: 7227:Dmel_CG3071
uniprot id: Q9W4Z9
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG16868
gene id: 7227:Dmel_CG16868
uniprot id: Q5BI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel subunit alpha-2/delta family.
messages: Membrane

7227:Dmel CG34370
gene id: 7227:Dmel_CG34370
uniprot id: A8DYL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG15168
gene id: 7227:Dmel_CG15168
uniprot id: Q9VJ25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

7227:Dmel CG31823
gene id: 7227:Dmel_CG31823
uniprot id: Q8IP31
names: Similarity
messages: Belongs to the peptidase S10 family.

7227:Dmel CG8261
gene id: 7227:Dmel_CG8261
uniprot id: P38040
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Predominantly expressed in the central nervous system.

7227:Dmel CG7279
gene id: 7227:Dmel_CG7279
uniprot id: O46107
uniprot id: X2JDS0
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Could be a digestive enzyme.
messages: Expressed from 14 hours embryos through to adulthood. There is a weak maternal contribution to early embryos.
messages: In 14 hours embryos expression is seen in the foregut/midgut boundary.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Secreted

7227:Dmel CG18284
gene id: 7227:Dmel_CG18284
uniprot id: Q9VKS9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG11901
gene id: 7227:Dmel_CG11901
uniprot id: A0A0B4JD11
uniprot id: Q9NJH0
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

7227:Dmel CG8333
gene id: 7227:Dmel_CG8333
uniprot id: Q01070
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in sensory organ precursors in the wing, leg and eye imaginal disk.
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Homodimer (PubMed:22357926). Heterodimer with dpn (PubMed:22357926). Might form higher-order oligomers (PubMed:22357926). Transcription repression requires formation of a complex with a corepressor protein (Groucho) (By similarity).
messages: In embryo, detected in the neuroectoderm at stage 8, and later in neuroblasts at stage 9 (at protein level) (PubMed:22357926). By stage 16, detected only in the neuroblasts (at protein level) (PubMed:22357926). In larvae, detected in a subset of neuroblasts, some of which will give rise to the optic lobe (at protein level) (PubMed:22357926). In embryo, detected during the initial stages of germ band exclusively within the neuroectoderm, both in the territory of the trunk and in cephalic regions (PubMed:1427040). During stage 9, detected within the procephalic lobe and the ventral ectoderm (PubMed:1427040).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
messages: Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:24618901). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae (PubMed:10790334, PubMed:22357926). In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) derived from type II neuroblasts (PubMed:24618901).

7227:Dmel CG4482
gene id: 7227:Dmel_CG4482
uniprot id: Q7KT87
uniprot id: Q9VJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

7227:Dmel CG9820
gene id: 7227:Dmel_CG9820
uniprot id: P81923
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in neurons of the third antennal segment.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, anisole, hexanoic acid, and pyrazines.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG18558
gene id: 7227:Dmel_CG18558
uniprot id: Q9VQH7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32575
gene id: 7227:Dmel_CG32575
uniprot id: Q9VXG1
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed ubiquitously in the nervous system, in neurons not glia.
messages: Flies exhibit defective responses to environmental stressors, such as heat and the free-radical-generating agent paraquat.
messages: Nucleus
messages: Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine.
messages: Stress, at both the cellular and systemic levels, contributes to drug- and addiction-related behaviors in mammals. Function of hang suggests that this role may be conserved across evolution.

7227:Dmel CG1814
gene id: 7227:Dmel_CG1814
uniprot id: A1Z7V8
uniprot id: A1Z7V9
uniprot id: Q7K3S2
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7227:Dmel CG4605
gene id: 7227:Dmel_CG4605
uniprot id: O46203
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Responsible for physiological and behavioral changes in mated female flies.
messages: Secreted
messages: Seminal fluid.

7227:Dmel CG13549
gene id: 7227:Dmel_CG13549
uniprot id: Q0E8X9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10964
gene id: 7227:Dmel_CG10964
uniprot id: Q9W3H4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG14526
gene id: 7227:Dmel_CG14526
uniprot id: Q9Y136
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG3347
gene id: 7227:Dmel_CG3347
uniprot id: Q9VQN2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13018
gene id: 7227:Dmel_CG13018
uniprot id: Q4V429
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

7227:Dmel CG5609
gene id: 7227:Dmel_CG5609
uniprot id: Q9VDH4
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A humoral factor that may play a role in stress tolerance.
messages: Belongs to the Turandot family.
messages: By a variety of stressful conditions including bacterial infection, heat shock and exposure to ultraviolet light.
messages: Expressed in late stage embryos. Disappears by early larval states and reappears in the third larval instar. Subsequently maintained throughout pupal development until adulthood.
messages: Secreted

7227:Dmel CG10521
gene id: 7227:Dmel_CG10521
uniprot id: Q24568
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At 24 hr after puparium formation (APF), detected in the most anterior (oldest) L3, L4 and L5 lamina neurons (at protein level) (PubMed:29513217). At 48 hr APF, expressed in all L3, L4 and L5 neurons with slightly higher expression in the L3 neurons (at protein level) (PubMed:29513217). At the midline of developing CNS and in different subsets of neurons, muscles, and epidermal patches (PubMed:8780645, PubMed:8780646).
messages: Binds to unc-5 and fra receptors.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons (PubMed:8780645, PubMed:8780646, PubMed:11719202). Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively (PubMed:11719202). While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5 (PubMed:11719202).
messages: extracellular matrix
messages: perinuclear region

7227:Dmel CG3893
gene id: 7227:Dmel_CG3893
uniprot id: Q8SWX0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for repression of transposons and neighboring genes in ovarian somatic and germline cells.
messages: Belongs to the UPF0224 (FAM112) family.
messages: Interacts with piwi.
messages: Mutant females are viable but sterile (PubMed:23913922). They have small and severely deformed ovaries (PubMed:23913921, PubMed:23913922). Soma- and germline-specific transposable elements are severely derepressed in the ovary (PubMed:23913922). Ovaries lack a follicle cell layer and show misexpression of orb (PubMed:23913921).
messages: Nucleus
messages: The zinc fingers are required for transcriptional silencing activity.

7227:Dmel CG3059
gene id: 7227:Dmel_CG3059
uniprot id: M9PBV2
uniprot id: O76268
uniprot id: Q8IPZ6
uniprot id: Q9VQI8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7227:Dmel CG7665
gene id: 7227:Dmel_CG7665
uniprot id: Q9VEG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG33993
gene id: 7227:Dmel_CG33993
uniprot id: Q6NR09
names: Disruption Phenotype
names: Function
names: Subunit
names: Tissue Specificity
messages: Detected along the wing margin, with high levels of expression in two stripes of cells on either side of the dorsal/ventral boundary and lower levels of expression in a small region at the anteroposterior boundary (at protein level) (PubMed:34411095). High levels of expression along two parallel stripes of cells on either side of the wing pouch dorsal/ventral boundary, and slightly lower levels of expression in a region either side of the anteroposterior boundary (PubMed:34411095). Also expressed in discrete regions of the wing imaginal disk outside of the pouch (PubMed:34411095). Expressed in eye imaginal disk photoreceptors with highest levels of expression in R7 photoreceptor cells (PubMed:34411095).
messages: Involved in the negative regulation of the Egfr/Ras signaling pathway (PubMed:34411095). During wing morphogenesis, may function redundantly with PVRAP to inhibit Egfr activity and prevent uncontrolled cell growth (PubMed:34411095).
messages: May interact (via SH2 domain) with Egfr (when phosphorylated).
messages: RNAi-mediated knockdown in adults does not result in a visible phenotype (PubMed:34411095). However, simultaneous knockdown of EGFRAP (CG33993) and PVRAP results in the development of ectopic sensory organs in the notum and blisters in the wings (PubMed:34411095). RNAi-mediated knockdown in the posterior compartment of the wing disks, increases expression of PEK (PubMed:34411095).

7227:Dmel CG6845
gene id: 7227:Dmel_CG6845
uniprot id: Q961F6
uniprot id: Q9W0V0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10915
gene id: 7227:Dmel_CG10915
uniprot id: Q8SX68
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Named 'Nausicaa' after the princess in Homer's 'The Odyssey' who helps to ensure Odysseus' safe passage home from Phaeacia.
messages: Regulates lamellipodial actin dynamics in a Cortactin-dependent manner and is therefore likely involved in controlling actin branch density, actin-retrograde flow rates and lamellipodial protrusion. Functions by slowing the dissociation of Cortactin from Arp2/3 nucleated branches thereby increasing branch nucleation and junction stability.
messages: lamellipodium
messages: stress fiber

7227:Dmel CG1495
gene id: 7227:Dmel_CG1495
uniprot id: A4V110
uniprot id: Q7JMV3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG7391
gene id: 7227:Dmel_CG7391
uniprot id: O61735
names: Domain
names: Function
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters.
messages: Contains three polyglutamine repeats which could correspond to the transactivation domain. The length of the repeats is polymorphic. In the arrhythmic mutant JRK, deletion of this region leads to the loss of circadian rhythmicity and altered light response.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with Cycle.
messages: Nucleus
messages: The variability in length of the polyglutamine stretch is due to polymorphism of this region. Variant B encodes two conceptual proteins, the first consists only of the bHLH domain, the other consists of the PAS-1 and all C-terminal domains. Variant B is expressed weakly at all the times of the day, and it cycles in phase with the full-length form.
messages: Widely expressed. Found in head, body, and appendage fractions.

7227:Dmel CG8696
gene id: 7227:Dmel_CG8696
uniprot id: P07190
names: Developmental Stage
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.

7227:Dmel CG32792
gene id: 7227:Dmel_CG32792
uniprot id: B7Z123
uniprot id: Q0KHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG30343
gene id: 7227:Dmel_CG30343
uniprot id: A0A0B4K7V3
names: Similarity
messages: Belongs to the SEN15 family.

7227:Dmel CG16894
gene id: 7227:Dmel_CG16894
uniprot id: A1ZBR5
names: Caution
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.

7227:Dmel CG1474
gene id: 7227:Dmel_CG1474
uniprot id: B5RIV5
uniprot id: O44424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

7227:Dmel CG1763
gene id: 7227:Dmel_CG1763
uniprot id: P18105
uniprot id: X2JEV2
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Embryonic, larval, and pupal stages. Only expressed in female adults.
messages: In adult female, found in meiotically active ovaries.
messages: Required for the distributive chromosome segregation of non-exchange chromosomes during meiosis. May be a microtubule motor required to hold distributively 'paired' chromosomes at the metaphase plate until anaphase.
messages: The nod(DTW) mutation is a cold-sensitive recessive lethal mutation.
messages: cytoskeleton

7227:Dmel CG2943
gene id: 7227:Dmel_CG2943
uniprot id: A0A0B4LGV1
uniprot id: Q9VHY6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG17976
gene id: 7227:Dmel_CG17976
uniprot id: A0A0B4KEF1
uniprot id: Q7KJP2
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7227:Dmel CG1828
gene id: 7227:Dmel_CG1828
uniprot id: Q8IRG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is required for expression of Hox genes.
messages: Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp. Interacts with TRL/GAGA.
messages: Nucleus

7227:Dmel CG9155
gene id: 7227:Dmel_CG9155
uniprot id: Q23979
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Binds F-actin.
messages: Cell membrane
messages: Cytoplasm
messages: Expression starts at 8-12 hours embryonic development, continues to increase until third larval instar, disappears in pupae and is present at a low level in adults. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. In third instar larvae, detected in segment A8 of the male genital disk (PubMed:22491943). First detected at stage 12 in the embryonic anterior and posterior midgut, and in the stomatogastric nervous system. Detected in trachea at stage 14. Widely expressed in stage 16 in embryos (PubMed:25659376).
messages: In the embryo, expressed in gastric caeca, midgut cells of the proventriculus, and in the mid and hindgut. In the larval and adult gut brush border, expressed in the microvilli. Also expressed at high levels in follicle cells during oogenesis.
messages: Overexpression in larval epidermis causes sinistral twisting of the whole larval body. Ectopic expression in tracheal precursor cells causes sinistral spiraling of tracheal branches, giving rise to a spiraling ribbon shape instead of the normal smooth tube. Ectopic expression in epithelial cells causes increased elongation and a clear shift of the membrane orientation toward one side, so that the membrane is no longer perpendicular to the anterior-posterior axis (PubMed:30467170). Overexpression causes reversal of the normal left-right laterality of the embryonic midgut and hindgut (PubMed:16598258, PubMed:18521948). Overexpression causes loss of the normal dextral rotation of the male genitalia, and leads to sinistral rotation in some cases (PubMed:22491943).
messages: The myosin motor domain contains the derminants for the direction of left-right body asymmetry.
messages: Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Functions as antagonist for Myo31DF, an unconventional myosin with an essential role in the establishment of body left-right asymmetry (PubMed:16598258, PubMed:18521948, PubMed:22491943, PubMed:25659376, PubMed:30467170).
messages: Viable and fertile, but adults have a shortened lifespan. Flies deficient in both Myo31DF and Myo61F are viable and fertile, but adults have a shorter lifespan than single mutants. Flies deficient in Myo61F show normal left-right asymmetry of the embryonic gut and normal, dextral rotation of male genitalia, and the same is observed in mutants deficient in both Myo61F and Myo95E. Mutants deficient in Myo31DF and Myo61F display stronger sinistral rotation of the male genitalia than mutants deficient for Myo31DF (PubMed:25659376). RNAi-mediated knockdown causes defects in embryonic midgut laterality, but only with low-frequency (PubMed:16598258). RNAi-mediated knockdown has no effect on normal, dextral rotation of male genitalia (PubMed:22491943). Combined RNAi-mediated knockdown of Myo31DF and Myo61F gives rise to the same phenotype as knockdown of Myo31DF alone, i.e sinistral rotation of the male genitalia (PubMed:22491943).
messages: cell cortex

7227:Dmel CG6584
gene id: 7227:Dmel_CG6584
uniprot id: A0A1B2AJD1
uniprot id: A0A1B2AJI9
uniprot id: A0A1B2AKC4
uniprot id: D3DMP0
uniprot id: Q8INK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.
messages: Nucleus
messages: Present in the embryonic nervous system (brain and cord) in neuronal cell bodies, along axons. Also present in embryonic muscles in motor axons. Localizes to growing bristle tips where it is distributed in small puntae. Present at and at sites of actin localization.
messages: cytoskeleton

7227:Dmel CG18102
gene id: 7227:Dmel_CG18102
uniprot id: A4V4I8
uniprot id: A4V4J0
uniprot id: E1JJA4
uniprot id: E1JJA5
uniprot id: M9PHQ0
uniprot id: M9PJN9
uniprot id: P27619
uniprot id: X2JE15
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: 'Shibire' means 'paralyzed' in Japanese.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Chimeric cDNA. There is a 6 amino acid insertion at position 634 due to a chimera of DNA from chromosome arms X and 3L.
messages: Cytoplasm
messages: Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.
messages: Shibire mutation is the cause of temperature-sensitive paralysis. This is believed to be due to a reversible block of endocytosis, which prevents membrane cycling and thus depletes synaptic vesicles.
messages: cytoskeleton

7227:Dmel CG31075
gene id: 7227:Dmel_CG31075
uniprot id: A0A0B4K6I6
uniprot id: Q9VB96
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7227:Dmel CG7789
gene id: 7227:Dmel_CG7789
uniprot id: Q9VAG9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG8717
gene id: 7227:Dmel_CG8717
uniprot id: A0A0B4LET7
uniprot id: Q7JVE7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Expressed throughout development with the highest expression in embryos from 4 to 12 h. Expressed in the salivary glands from stage 11, when the placodes are being specified.
messages: Golgi apparatus membrane
messages: Mediates both low-affinity uptake and efflux of sugar across the membrane.
messages: Mediates sugar transport across membranes.
messages: Membrane

7227:Dmel CG33894
gene id: 7227:Dmel_CG33894
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG33544
gene id: 7227:Dmel_CG33544
uniprot id: A1ZAJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG7024
gene id: 7227:Dmel_CG7024
uniprot id: Q9W4H4
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

7227:Dmel CG1291
gene id: 7227:Dmel_CG1291
uniprot id: Q9VZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

7227:Dmel CG4084
gene id: 7227:Dmel_CG4084
uniprot id: C4IXX8
uniprot id: Q27333
names: Developmental Stage
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Expressed only in embryos.
messages: In strains Harvich and Apxo, there are 2 genes which code for l(2)not protein. They differ in their C-terminus.
messages: Membrane

7227:Dmel CG7144
gene id: 7227:Dmel_CG7144
uniprot id: Q9VLX0
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

7227:Dmel CG33848
gene id: 7227:Dmel_CG33848
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG3961
gene id: 7227:Dmel_CG3961
uniprot id: E2QCY2
uniprot id: M9PCX4
uniprot id: Q9VVT8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

7227:Dmel CG4061
gene id: 7227:Dmel_CG4061
uniprot id: O77264
uniprot id: X2JI07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: nucleoplasm

7227:Dmel CG31547
gene id: 7227:Dmel_CG31547
uniprot id: Q9VNC6
uniprot id: Q9VNC7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2091
gene id: 7227:Dmel_CG2091
uniprot id: Q9VNH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Nucleus

7227:Dmel CG18741
gene id: 7227:Dmel_CG18741
uniprot id: A0A0B4KI18
uniprot id: Q24563
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in both central and peripheral nervous systems.
messages: Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning.

7227:Dmel CG2520
gene id: 7227:Dmel_CG2520
uniprot id: A0A0B4K603
uniprot id: A0A0B4K631
uniprot id: A0A0B4K6V2
uniprot id: A0A0B4KF90
uniprot id: A0A0B4KFE2
uniprot id: A0A0B4KGC6
uniprot id: B7Z0U7
uniprot id: E1JJ78
uniprot id: Q9VI75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
messages: Belongs to the PICALM/SNAP91 family.
messages: Binds clathrin and phosphatidylinositol 4,5-bisphosphate.
messages: Golgi apparatus
messages: In embryos, expression is seen in central and peripheral nervous systems (brain and ventral nerve cord) and Garland cells. Coexpressed with clathrin at presynaptic boutons of neuromuscular junctions.
messages: clathrin-coated pit
messages: clathrin-coated vesicle

7227:Dmel CG31280
gene id: 7227:Dmel_CG31280
uniprot id: C9QPH3
uniprot id: Q8IMZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: In larvae, is expressed in neurons of the terminal external chemosensory organ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG15556
gene id: 7227:Dmel_CG15556
uniprot id: Q9VA10
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4679
gene id: 7227:Dmel_CG4679
uniprot id: A1Z9A8
uniprot id: T2FGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrial protein that may have a role in mitochondrial translation.
messages: Mitochondrion

7227:Dmel CG8271
gene id: 7227:Dmel_CG8271
uniprot id: Q5U154
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7780
gene id: 7227:Dmel_CG7780
uniprot id: Q9VED8
names: Similarity
messages: Belongs to the DNase II family.

7227:Dmel CG3629
gene id: 7227:Dmel_CG3629
uniprot id: A2VEF7
uniprot id: P20009
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the embryo in limb primordia of the head and thoracic segments. Expressed in regions of the larval leg, wing, antennal and haltere disks that form the distal-most regions of the mature structures (in the leg this corresponds to the tarsus and the distal tibia). Found in the optic center of the developing larval brain.
messages: Nucleus
messages: Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.

7227:Dmel CG4125
gene id: 7227:Dmel_CG4125
uniprot id: Q08180
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Membrane
messages: Postembryonic expression is strong in the developing optic lobe and in the eye imaginal disk.
messages: Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina.
messages: Strongly expressed in embryos. Also found in late larval and pupal stages.

7227:Dmel CG1587
gene id: 7227:Dmel_CG1587
uniprot id: H9XVM6
uniprot id: Q95RW2
uniprot id: Q9XYM0
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.
messages: Belongs to the CRK family.
messages: Embryonic zygotic expression is seen in invaginating presumptive mesoderm and ectodermally derived tissues during gastrulation. At stage 8, expression is also seen in anterior and posterior midgut and cephalic furrow. By stage 9, expression is highest in visceral mesoderm of anterior and posterior midgut, ventral nerve cord and somatic mesoderm.
messages: Expressed both maternally and zygotically throughout embryogenesis, declines during larval stages and reappears during pupation.

7227:Dmel CG33653
gene id: 7227:Dmel_CG33653
uniprot id: Q9NHE5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
messages: Cytoplasmic vesicle membrane
messages: Flies display locomotory deficits and complete embryonic lethality. The mutant NMJ reveals a 50% loss in evoked glutamatergic transmission, and an accumulation of synaptic vesicles at active zones. They also display a 3-fold accumulation of DCVs in synaptic terminals.
messages: Incomplete sequence.
messages: Not detected in early embryos through stage 8. Strongly expressed in neural-specific cells at the onset of early stages of neuronal differentiation beginning at stage 9-10. Accumulates from stage 12 through the rest of embryogenesis in all neuronal cells within the brain and ventral nerve cord (VNC). Remains restricted to the central nervous system and not detected in other tissues at any stage of development.
messages: Restricted to the nervous system at all stages of development and highly localized at synapses (at protein level).
messages: Synapse
messages: The PH domain is essential for regulated exocytosis and binds phospholipids.

7227:Dmel CG9154
gene id: 7227:Dmel_CG9154
uniprot id: H0RNC9
uniprot id: Q9VMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

7227:Dmel CG32183
gene id: 7227:Dmel_CG32183
uniprot id: Q9VVK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG44252
gene id: 7227:Dmel_CG44252
uniprot id: Q7KVJ6
uniprot id: Q9W1W0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG5198
gene id: 7227:Dmel_CG5198
uniprot id: Q9VKV5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Embryonic lethal. Embryonic wound healing defects. The few adult escapers show subtle rough eye phenotype and extra and/or misplaced or missing macrochaetae on the scutellum.
messages: Expressed maternally and zygotically. Expression is ubiquitous throughout embryonic development.
messages: Nucleus
messages: Required for embryonic epithelial tissue repair, but not for the assembly of the actomyosin cable at the wound edge. Probably acts downstream of rl in the regulation of Ddc and msn transcription to promote wound healing.

7227:Dmel CG18003
gene id: 7227:Dmel_CG18003
uniprot id: A1Z8D3
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

7227:Dmel CG18290
gene id: 7227:Dmel_CG18290
uniprot id: A0A0B4LH50
uniprot id: P10981
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.
messages: In Drosophila there are 6 closely related actin genes.
messages: Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
messages: Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
messages: cytoskeleton

7227:Dmel CG5393
gene id: 7227:Dmel_CG5393
uniprot id: A0A0B4KGD0
uniprot id: O61602
uniprot id: Q8MLR4
uniprot id: Q9W1M6
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG13568
gene id: 7227:Dmel_CG13568
uniprot id: A0A0B4LGF3
uniprot id: A8DYP1
uniprot id: A8DYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG6446
gene id: 7227:Dmel_CG6446
uniprot id: Q7KK54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG4354
gene id: 7227:Dmel_CG4354
uniprot id: A0A0B4LGG2
uniprot id: Q02637
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At stage 9 detected in centrally located anterior polar cells, and in border cells before and as they migrate (at protein level). At stage 10, detected in centripetal cells and levels decrease in border cells as they finish migrating (at protein level).
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a dimer and can form stable heterodimers (PubMed:1459454). Interacts with trbl (PubMed:23305818).
messages: Nucleus
messages: Required for the expression of gene products mediating border cell migration (PubMed:1459454, PubMed:10949024, PubMed:23305818). Among the DNA sequences that this protein binds with high affinity is a conserved site within the promoter of its gene (PubMed:1459454).
messages: Ubiquitination/deubiquitination regulates border cell migration. Ubiquitination is stimulated by trbl, which leads to proteasomal degradation and inhibits border cell migration. Deubiquitination by Usp47, leads to its stabilization and promotes border cell migration.

7227:Dmel CG18497
gene id: 7227:Dmel_CG18497
uniprot id: Q8SX83
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RRM Spen family.
messages: Isoform 3 is expressed both maternally and zygotically.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Nucleus
messages: Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins.
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1.
messages: Produced by alternative splicing of isoform 2.
messages: Ubiquitous. Expressed prior to cellularization in stage 3 embryos, and in blastoderm cells, including pole cells. Expressed throughout the rest of embryogenesis. Later, it is expressed at higher level in epidermal cells and CNS.

7227:Dmel CG4272
gene id: 7227:Dmel_CG4272
uniprot id: Q9U4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

7227:Dmel CG30463
gene id: 7227:Dmel_CG30463
uniprot id: Q8MRC9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:30158631). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:30158631).
messages: Expressed both maternally and zygotically (PubMed:16251381). Expressed through embryonic and larval stages (PubMed:16251381). During embryonic stages 9-11, expressed in the developing anterior midgut and amnioserosa (PubMed:16251381). Expressed in the salivary glands from embryonic stage 12 onwards (PubMed:16251381). During embryonic stages 12-13, still expressed in the amnioserosa region (PubMed:16251381). In third instar larvae, expressed ubiquitously in wing, with increased expression in the notum and ventral wing pouch, leg and haltere imaginal disks (PubMed:16251381). In eye-antennal imaginal disk, expressed in the presumptive eye region only (PubMed:16251381). Isoform A: Expressed in trachea, midgut, salivary gland, hindgut, central nervous system and Malpighian tubules (PubMed:30158631). Isoform B: Specifically expressed in the salivary gland (PubMed:30158631).
messages: Golgi apparatus membrane
messages: Intron retention.
messages: Isoform A forms homotetramer. Isoform B forms homodimer.
messages: N-acetylgalactosaminyltransferase which preferentially O-glycosylates negatively charge substrates. O-glycosylates mucin-like protein Sgs3 in the salivary gland but to a lesser extent than isoform B. By regulating the O-glycosylation of secretory cargo proteins plays a role in the morphology and maturation of salivary gland secretory granules.
messages: N-acetylgalactosaminyltransferase which preferentially O-glycosylates positively charge substrates. O-glycosylates mucin-like protein Sgs3 in the salivary gland. By regulating the O-glycosylation of secretory cargo proteins, plays a role in the morphology and maturation of salivary gland secretory granules.
messages: RNAi-mediated knockdown in the whole body, in the mesoderm, the respiratory system or the amnioserosa results in lethality (PubMed:22157008). RNAi-mediated knockdown in the epidermis or the digestive system and reproductive tract results in a reduction in viability (PubMed:22157008). RNAi-mediated knockdown in salivary glands results in aberrant secretory granule morphology showing angular, shard-like morphology (PubMed:30158631).
messages: The alpha subunit loop in the ricin B-type lectin domain regulates substrate specificity and modulates the substrate access to the active site. In isoform A, the alpha subunit loop is composed of positively charged residues and acts on negatively charged substrates. In isoform B, the alpha subunit loop is composed of negatively charged residues and acts on positively charged substrates.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG33853
gene id: 7227:Dmel_CG33853
uniprot id: Q4AB57
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG7276
gene id: 7227:Dmel_CG7276
uniprot id: Q7KUM9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7227:Dmel CG3268
gene id: 7227:Dmel_CG3268
uniprot id: Q9V9A8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG18559
gene id: 7227:Dmel_CG18559
uniprot id: P82713
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG3726
gene id: 7227:Dmel_CG3726
uniprot id: Q8SWW7
uniprot id: X2JDV1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG11094
gene id: 7227:Dmel_CG11094
uniprot id: A0A0B4KFS4
uniprot id: A0A0B4KGR7
uniprot id: A0A0B4LGS9
uniprot id: P23023
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.
messages: Experimentally shown to bind zinc.
messages: Nucleus

7227:Dmel CG5880
gene id: 7227:Dmel_CG5880
uniprot id: Q9VB73
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG5748
gene id: 7227:Dmel_CG5748
uniprot id: P22813
uniprot id: Q4H2F7
uniprot id: Q4H2F8
uniprot id: Q4H2F9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HSF family.
messages: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
messages: Exhibits temperature-dependent phosphorylation.
messages: Homotrimer.
messages: Nucleus

7227:Dmel CG2944
gene id: 7227:Dmel_CG2944
uniprot id: A0A0B4K6X3
uniprot id: A1Z6E0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPSB family.
messages: Cytoplasm
messages: Expressed during oogenesis, in early embryos (0 to 4 hours) and in fertile adult females (at protein level).
messages: Expressed in ovaries, primarily in nurse cells and oocytes (at protein level).
messages: Homozygous females produce defective eggs, which desiccate and collapse soon after egg laying, or embryos, which hatch very rarely. Mutants exhibit wing morphology defects, including blistering, formation of ectopic vein material, and loss of material at the margin.
messages: Interacts (via B30.2/SPRY domain) with vas; this interaction may be necessary for the transport of vas to the posterior pole of the oocyte. Interacts with Cul-5. May associate with the Elongin BC complex composed of Elongin-B and Elongin-C.
messages: Involved in the localization of vas to the posterior pole of the oocyte. Required maternally in the germ line for efficient primordial germ cell formation.
messages: Nucleus

7227:Dmel CG12034
gene id: 7227:Dmel_CG12034
uniprot id: Q9VZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neutral sphingomyelinase family.
messages: Membrane

7227:Dmel CG14749
gene id: 7227:Dmel_CG14749
uniprot id: Q9V4W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLE1 family.
messages: Cytoplasm
messages: May associate with the NPC.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
messages: nuclear pore complex

7227:Dmel CG1709
gene id: 7227:Dmel_CG1709
uniprot id: Q6NLA3
uniprot id: Q8IML3
uniprot id: Q8IML4
uniprot id: Q8IML5
uniprot id: Q9XZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7227:Dmel CG7656
gene id: 7227:Dmel_CG7656
uniprot id: Q8IQM5
uniprot id: Q9VUR4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG8593
gene id: 7227:Dmel_CG8593
uniprot id: M9PEL3
uniprot id: Q9VS54
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

7227:Dmel CG3978
gene id: 7227:Dmel_CG3978
uniprot id: A0A0B4KH81
uniprot id: A8WHL1
uniprot id: P52168
uniprot id: Q9VEZ8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with OSA.
messages: It is first seen in the dorsal portion of the embryo just after cellularization and is expressed at high levels during early embryogenesis and as development progresses high levels are seen in the dorsal epidermis.
messages: Nucleus
messages: Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.

7227:Dmel CG12653
gene id: 7227:Dmel_CG12653
uniprot id: Q24266
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: First expressed in a stripe covering the head anlagen of the syncytial blastoderm embryo, persists through gastrulation and decays during germ band extension. Expressed later in development in a complex spatially restricted pattern.
messages: Nucleus
messages: Required for the development of the antennal, intercalary and mandibular segments of the head.

7227:Dmel CG6168
gene id: 7227:Dmel_CG6168
uniprot id: Q9VTH7
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

7227:Dmel CG4919
gene id: 7227:Dmel_CG4919
uniprot id: Q9VCW6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

7227:Dmel CG42796
gene id: 7227:Dmel_CG42796
uniprot id: A0A0B4KFU6
uniprot id: Q8INQ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG7288
gene id: 7227:Dmel_CG7288
uniprot id: Q9VWP1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG16778
gene id: 7227:Dmel_CG16778
uniprot id: A0A0B4LGK1
uniprot id: P14083
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Has a regulatory role during midline cell development.
messages: Initially expressed at blastoderm stage, transient accumulation at dorso-lateral positions of the embryo and differences along the longitudinal axis. At later stages of embryogenesis, expression is found exclusively in neural anlagen. Expressed in 4 posterior-most ventral unpaired median interneurons (VUM) neurons, VUM interneurons and one progeny of the median neuroblast (MNB).
messages: Nucleus
messages: Was originally thought to be a kinase on the basis of weak and non-significant similarities.

7227:Dmel CG31682
gene id: 7227:Dmel_CG31682
uniprot id: Q8IPY9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7227:Dmel CG10361
gene id: 7227:Dmel_CG10361
uniprot id: Q9VTN9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

7227:Dmel CG8224
gene id: 7227:Dmel_CG8224
uniprot id: A1Z7L8
uniprot id: A1Z7L9
uniprot id: Q7YU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Belongs to the scoloptoxin-05 family.
messages: Membrane

7227:Dmel CG7526
gene id: 7227:Dmel_CG7526
uniprot id: M9PHP7
uniprot id: Q9VS89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG41562
gene id: 7227:Dmel_CG41562
uniprot id: A8QI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

7227:Dmel CG11505
gene id: 7227:Dmel_CG11505
uniprot id: Q9I7T7
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
messages: Expressed throughout development and in adults. Ubiquitously expressed in the central nervous system and imaginal disks.
messages: Probable RNA binding protein. Negatively regulates myc at the protein level, via an unknown mechanism, and may therefore have a role in growth. Has no effect on myc mRNA levels.
messages: Probable cloning artifact.
messages: The HTH La-type RNA-binding and RRM domains are required for its function in negatively regulating organ and cell size.

7227:Dmel CG30031
gene id: 7227:Dmel_CG30031
uniprot id: C0HKA2
uniprot id: C0HKA3
uniprot id: C0HKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG9610
gene id: 7227:Dmel_CG9610
uniprot id: P23757
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in somatic mesoderm.
messages: Nucleus

7227:Dmel CG10699
gene id: 7227:Dmel_CG10699
uniprot id: M9NCY1
uniprot id: M9PD53
uniprot id: Q9VJ00
uniprot id: Q9VJ02
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG30329
gene id: 7227:Dmel_CG30329
uniprot id: A1ZBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7227:Dmel CG12253
gene id: 7227:Dmel_CG12253
uniprot id: Q9VKM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

7227:Dmel CG43313
gene id: 7227:Dmel_CG43313
uniprot id: Q9VYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7227:Dmel CG43795
gene id: 7227:Dmel_CG43795
uniprot id: A8DY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG1697
gene id: 7227:Dmel_CG1697
uniprot id: Q9VYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

7227:Dmel CG2855
gene id: 7227:Dmel_CG2855
uniprot id: M9PCE6
uniprot id: Q9VQG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
messages: Membrane

7227:Dmel CG17143
gene id: 7227:Dmel_CG17143
uniprot id: Q8IRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC7 family.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Part of the THO complex containing HPR1, THOC2, THOC5, THOC6 and THOC7.
messages: The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.

7227:Dmel CG6998
gene id: 7227:Dmel_CG6998
uniprot id: M9NDP1
uniprot id: Q24117
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a non-catalytic accessory component of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: Flies exhibit defects in bristle and wing development.
messages: Interacts with spn-F (PubMed:16540510). Forms ternary complexes with spn-F and IKKepsilon (PubMed:26092846, PubMed:26540204).
messages: Ubiquitous.
messages: cytoskeleton

7227:Dmel CG34333
gene id: 7227:Dmel_CG34333
uniprot id: A8JUV4
names: Function
messages: Major early eggshell protein.

7227:Dmel CG8389
gene id: 7227:Dmel_CG8389
uniprot id: Q0E960
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9025
gene id: 7227:Dmel_CG9025
uniprot id: A1ZBY1
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the fem-1 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex.
messages: Primarily detected in the embryonic central nervous system.
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.

7227:Dmel CG14901
gene id: 7227:Dmel_CG14901
uniprot id: Q9VEU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr77a subfamily.
messages: Cell membrane
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG4845
gene id: 7227:Dmel_CG4845
uniprot id: Q9VDQ7
uniprot id: U3Q053
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MDM20/NAA25 family.
messages: Component of the N-terminal acetyltransferase B (NatB) complex.
messages: Expressed in the fat body after immune challenge.
messages: Flies are deficient in the induction of Defensin whether the infection was with a Gram-negative or Gram-positive micro-organism.
messages: Lysosome
messages: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body. Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response.

7227:Dmel CG7603
gene id: 7227:Dmel_CG7603
uniprot id: A0A1B2AJ92
uniprot id: Q9VVH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG6583
gene id: 7227:Dmel_CG6583
uniprot id: Q9VKA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG32669
gene id: 7227:Dmel_CG32669
uniprot id: P83740
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane

7227:Dmel CG12414
gene id: 7227:Dmel_CG12414
uniprot id: A0A0S0WNY8
uniprot id: A8JNX5
uniprot id: M9NE13
uniprot id: M9PDC9
uniprot id: Q95RL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG16788
gene id: 7227:Dmel_CG16788
uniprot id: Q9VHC0
names: Similarity
messages: Belongs to the splicing factor SR family.

7227:Dmel CG9867
gene id: 7227:Dmel_CG9867
uniprot id: Q9VQB7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp).
messages: Defects in apical extracellular matrix. Embryos show defects in the formation of the innermost layer of the apical extracellular matrix and its attachment to the epidermis. Most larvae die during second-instar or second/third-instar interface, but some survive until early third-instar. Surviving larvae display cuticle defect and irregular tracheal morphology. Ultrastructural analysis of larval epidermis reveals disruption of the deposition zone of the endocuticle, leading to separation of the epidermis from the chitin layers.
messages: Endoplasmic reticulum lumen
messages: Expressed both maternally and zygotically. Highly expressed in preblastoderm-stage embryos. During the later stages of embryogenesis, expression is ubiquitous with the level progressively decreasing.

7227:Dmel CG11654
gene id: 7227:Dmel_CG11654
uniprot id: M9PHN8
uniprot id: Q27580
uniprot id: X2JF40
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Interacts with AhcyL1; the interaction may negatively regulate Ahcy catalytic activity.
messages: RNAi-mediated knockdown results in increased S-adenosyl-homocysteine levels and reduced lifespan.

7227:Dmel CG1115
gene id: 7227:Dmel_CG1115
uniprot id: Q9VN88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Late endosome membrane

7227:Dmel CG11200
gene id: 7227:Dmel_CG11200
uniprot id: Q7K0F7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG13095
gene id: 7227:Dmel_CG13095
uniprot id: Q9VLK3
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG5575
gene id: 7227:Dmel_CG5575
uniprot id: O77459
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Highly expressed in embryos and pupae, and at lower level in larvae. In adults, it is expressed at higher level in females.
messages: Expressed from stage 5 in two rather faint stripes at positions of 64% (anterior domain; AD) and 17% (posterior domain; PD) egg length. During early gastrulation, at stage 6, these two stripes become more evident and detectable at the region posterior to the cephalic furrow and in the hindgut primordium. The AD disappears as gastrulation proceeds, while the PD remains. At stage 15, the AD appears again in the foregut, and PD expression in the hindgut and anal pad. In imaginal disks, it is ubiquitously expressed in both males and females in genital and eye-antennal disks. Not expressed in the brain. In genital disks, it is expressed along the margin of the anterior bulbus in males, while in females it is expressed in the posterior compartment along the anterior-posterior border, with medial expansion in the most posterior region.
messages: Flies show low mating success and reduced copulation duration. Men and female genitalia often remain inside the body, and genitalia and analia are missing in some homozygous flies. These flies are named after the famous dolls who also lack these 'features'.
messages: Nucleus
messages: Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.

7227:Dmel CG30296
gene id: 7227:Dmel_CG30296
uniprot id: A0A0B4KFX1
uniprot id: A0A0B4LH23
uniprot id: E1JGP2
uniprot id: E1JGP3
uniprot id: E1JGP4
uniprot id: E1JGP5
uniprot id: E1JGP6
uniprot id: E1JGP7
uniprot id: E1JGP8
uniprot id: E1JGP9
uniprot id: E1JGQ0
uniprot id: E1JGQ1
uniprot id: Q058V3
uniprot id: Q9W2N3
uniprot id: Q9W2N4
names: Similarity
messages: Belongs to the ric-3 family.

7227:Dmel CG8988
gene id: 7227:Dmel_CG8988
uniprot id: Q7JZ56
names: Similarity
messages: Belongs to the peptidase M50A family.

7227:Dmel CG10795
gene id: 7227:Dmel_CG10795
uniprot id: Q9W2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

7227:Dmel CG31674
gene id: 7227:Dmel_CG31674
uniprot id: Q8INU6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7227:Dmel CG3649
gene id: 7227:Dmel_CG3649
uniprot id: Q9W1Y9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2175
gene id: 7227:Dmel_CG2175
uniprot id: P18169
uniprot id: P18170
uniprot id: P18171
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Allele FC1 is found only in strain Samarkand, allele FC3 only in strain Shahrinau and FC4 only in strain Dilizhan. Allele FC2 Is found in both strains Israel and Ghanghry.
messages: Expressed during embryonic stage 11.
messages: Expression peaks at embryonic stage 10A, is slightly reduced by stage 10B, and undetected in stage 11.
messages: Proteolytic cleavage of isoform FC106 generates 2 further products, S80 and S60.
messages: Required for proper assembly of the eggshell.
messages: Secreted
messages: Synthesized in early stage 10 egg chambers. Cleavage generates S80, a 80 kDa species, during late stage 10 which is incorporated into the eggshell. During the latter stages of chorion formation, S80 is processed to a 60 kDa component, S60.

7227:Dmel CG43155
gene id: 7227:Dmel_CG43155
uniprot id: Q9VYY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG42498
gene id: 7227:Dmel_CG42498
uniprot id: E1JIY8
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

7227:Dmel CG10561
gene id: 7227:Dmel_CG10561
uniprot id: P18487
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant in embryos and adults.
messages: Cytoplasm
messages: Has a non-vital function.
messages: Low levels seen in adult heads, thorax, abdomen and ovaries, high levels in testes.

7227:Dmel CG8330
gene id: 7227:Dmel_CG8330
uniprot id: A1Z6L1
uniprot id: H0RNC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria.
messages: Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex). Interacts with mitochondrial targeting sequences (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane
messages: Only expressed in the male germline, detected in primary spermatocytes as well as post-meiotic stages. Not detected in stem cells and spermatogonia near the tip of the testis.

7227:Dmel CG3455
gene id: 7227:Dmel_CG3455
uniprot id: Q9W414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG8859
gene id: 7227:Dmel_CG8859
uniprot id: Q9V675
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane
messages: More highly expressed in DDT-susceptible strains (Canton-S and 91-C) as compared to the DDT-resistant strains (91-R and Wisconsin).

7227:Dmel CG5912
gene id: 7227:Dmel_CG5912
uniprot id: A1Z9D7
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG4980
gene id: 7227:Dmel_CG4980
uniprot id: Q9VAY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

7227:Dmel CG33831
gene id: 7227:Dmel_CG33831
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG11425
gene id: 7227:Dmel_CG11425
uniprot id: Q9VNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7227:Dmel CG5343
gene id: 7227:Dmel_CG5343
uniprot id: Q9VKV8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CFAP20 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for sperm individualization, differentiation of the sperm flagellum and tubulin polyglycylation of axonemal microtubules.
messages: Expressed in spermatocytes and chordotonal organs in sensory neurons of the antenna.
messages: Flies are viable and develop until late pupal stages. Display defects in wing posture and inflation, in locomotion and climbing activities and have a reduced lifespan. Males produce immotile sperm and show defects in sperm individualization process within cysts. Display defects of polyglycylation incorporation in sperm axonemal microtubules.
messages: Nucleus
messages: centriole
messages: cilium
messages: flagellum
messages: nucleolus

7227:Dmel CG6383
gene id: 7227:Dmel_CG6383
uniprot id: A0A0B4K7R8
uniprot id: A0A0B4KHS1
uniprot id: P10040
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the Crumbs protein family.
messages: Component of the SAC complex, a complex composed of crb, Patj and sdt (PubMed:11740560, PubMed:10102271, PubMed:11076972). May interact with the par-6 complex, which is composed of par-6, baz and aPKC, via its interaction with Patj (PubMed:12900452, PubMed:10102271, PubMed:11076972). Interacts with other proteins with Patj and sdt via its short cytoplasmic tail (PubMed:11740560). Component of the CGX complex composed of crb, galla (galla-1 or galla-2) and Xpd (PubMed:25065591). Able to interact independently (via intracellular domain) with galla-1, galla-2 and Xpd (PubMed:25065591). Interacts with apn (PubMed:30645584).
messages: Expressed in the larval trachea (at protein level).
messages: Flies show severe disruptions in the organization of ectodermally derived epithelia and leading in some cases to cell death in these tissues (PubMed:2344615). RNAi-mediated knockdown in the whole body or tracheae results in depletion of its binding partner sdt, twisted tracheal tubes, lack of gas filling and reduced apical surfaces of tracheal tube cells with death occurring at larval stage 2 or 3 (PubMed:30645584). RNAi-mediated knockdown in germline cells results in severe chromosomal and spindle microtubule defects such as chromosome bridges, bent chromosomes, monopolar spindles and fusion with one or more neighboring spindles (PubMed:25065591).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated in the cytoplasmic domain.
messages: Plays a central role in cell polarity establishment, and contributes to the organization of zonula adherens, epithelial morphogenesis, and tissue growth (PubMed:2344615, PubMed:12900452, PubMed:10102271, PubMed:11740560). Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex (PubMed:11740560, PubMed:12900452, PubMed:10102271, PubMed:11076972). Controls the coalescence of the spots of zonula adherens (ZA) into an adhesive ring around the cells (PubMed:11740560). It may act as a signal (PubMed:2344615). Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina (PubMed:12900452). In cooperation with aPKC, required for the formation and maintenance of the rhabdomeric and stalk apical cortical membrane domains (PubMed:32579558). Recruits aPKC to the apical stalk membrane where it phosphorylates and displaces rhabdomere specifying proteins such as PIP82, to restrict their localization and thus activity to the rhabdomeric apical domain (PubMed:32579558). Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos (PubMed:25065591). The CGX complex is also required for cell proliferation in developing wing disks (PubMed:25065591). In the CGX complex, acts with galla-1 or galla-2 to recruit Xpd and thus form the functional complex. Together with apn, plays a key role in trachea development at larval stages (PubMed:30645584).
messages: spindle

7227:Dmel CG10605
gene id: 7227:Dmel_CG10605
uniprot id: P54269
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Caupolican' is named after the Araucanian American-Indian tribe, also called mohawks, who shaved all but a medial stripe of hairs on the head.
messages: Belongs to the TALE/IRO homeobox family.
messages: Controls proneural and vein forming genes. Positive transcriptional controler of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation.
messages: Nucleus

7227:Dmel CG4099
gene id: 7227:Dmel_CG4099
uniprot id: Q9V3H7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG13972
gene id: 7227:Dmel_CG13972
uniprot id: Q9VB28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

7227:Dmel CG3164
gene id: 7227:Dmel_CG3164
uniprot id: Q8IPV3
uniprot id: Q9VPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG4946
gene id: 7227:Dmel_CG4946
uniprot id: Q9VL13
names: Similarity
messages: Belongs to the MOB1/phocein family.

7227:Dmel CG12007
gene id: 7227:Dmel_CG12007
uniprot id: Q9VN77
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

7227:Dmel CG6869
gene id: 7227:Dmel_CG6869
uniprot id: I0DHK8
uniprot id: Q9VUL9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes alpha-1,3 glycosidic linkages of N-glycans (PubMed:11382750). Plays a role in neuronal development by promoting ventral nerve cord formation, possibly by promoting interactions between migrating cells and the extracellular matrix or by promoting neural activity (PubMed:21203496).
messages: Defective alpha-1,3-fucosylation activity and a significantly lower longitudinal length-to-width ratio of the ventral nerve cord (VNC).
messages: Golgi stack membrane

7227:Dmel CG3004
gene id: 7227:Dmel_CG3004
uniprot id: B4F5L6
uniprot id: Q9W328
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of a minimal complex, TORC1, consisting of tor, raptor and lst8. Interacts with tor but not raptor. Does not require raptor for binding to tor. Part of a minimal complex, TORC2, consisting of tor, rictor and lst8.
messages: Reduced tissue growth (PubMed:22493059, PubMed:25999153). Adults display an overall reduction in size with a 25% reduction in body weight, and have smaller wings and eyes (PubMed:22493059, PubMed:25999153). Reduced phosphorylation of Akt1 which is a direct target of the TORC2 complex but no effect on the phosphorylation of SK6 which is a major target of the TORC1 complex (PubMed:22493059).
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals (PubMed:22493059, PubMed:25999153). Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1 (PubMed:22493059, PubMed:25999153). However it is not required for TORC1-mediated functions such as TORC1-dependent regulation of cell growth, autophagy and phosphorylation of S6K (PubMed:22493059).
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1-dependent regulation of cell growth, autophagy and phosphorylation of S6K.

7227:Dmel CG3806
gene id: 7227:Dmel_CG3806
uniprot id: Q9W541
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

7227:Dmel CG12051
gene id: 7227:Dmel_CG12051
uniprot id: P02572
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: All cells and tissues of the developing embryo. Later in development, expression is higher in midgut, brain, nerve cord, and gonads.
messages: Belongs to the actin family.
messages: By 20-hydroxyecdysone.
messages: In Drosophila there are 6 closely related actin genes.
messages: Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
messages: Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
messages: cytoskeleton

7227:Dmel CG3201
gene id: 7227:Dmel_CG3201
uniprot id: P54357
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

7227:Dmel CG33834
gene id: 7227:Dmel_CG33834
uniprot id: Q4AB94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG5986
gene id: 7227:Dmel_CG5986
uniprot id: Q9VCE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

7227:Dmel CG8009
gene id: 7227:Dmel_CG8009
uniprot id: A0A1B2AJJ7
uniprot id: H9XQA7
uniprot id: Q8T0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: May form with the serine/threonine protein phosphatase l(1)G0269 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (By similarity).
messages: Membrane
messages: Nucleus membrane

7227:Dmel CG3567
gene id: 7227:Dmel_CG3567
uniprot id: A0A0B4LET2
uniprot id: Q9V979
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG12193
gene id: 7227:Dmel_CG12193
uniprot id: I6LU58
uniprot id: P81909
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed with Orco in 17-20 sensory neurons on the medial-proximal edge of the antenna. Expressed in the ab3A neuron which responds to ethyl butyrate.
messages: Interacts with Orco, via conserved C-terminal cytoplasmic loops. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway. Interacts with snmp1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG3671
gene id: 7227:Dmel_CG3671
uniprot id: A0A0B4K7L4
uniprot id: A0A0B4KGL5
uniprot id: A4V370
uniprot id: P49283
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Malvolio' is a character in Shakespeare's twelfth night, who 'taste(d) with distempered appetite'.
messages: Belongs to the NRAMP family.
messages: Expressed in macrophages and in the nervous system.
messages: Membrane
messages: Putative transporter required for normal taste behavior. May be a nitrite/nitrate transporter.

7227:Dmel CG11128
gene id: 7227:Dmel_CG11128
uniprot id: Q9VNP7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG43345
gene id: 7227:Dmel_CG43345
uniprot id: Q9VIE9
names: Similarity
messages: Belongs to the phospholipase D family.

7227:Dmel CG30152
gene id: 7227:Dmel_CG30152
uniprot id: A0A0B4LG04
uniprot id: A0A0B4LH12
uniprot id: Q9V968
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MIP18 family.
messages: Component of the CGX complex composed of crb, galla (galla-1 or galla-2) and Xpd. Interacts with crb (via intracellular domain). Is not able to interact with Xpd in the absence of crb.
messages: Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex.
messages: Expressed at low levels during larval stages, and at higher levels in pupae and adults (at protein level). Ubiquitously expressed in the wing disk (at protein level).
messages: Mutant flies show temperature-sensitive lethality. Prior to cellularization many embryos display signs of incomplete chromosome segregation during mitotic divisions likely due to defective organization of spindle microtubules.
messages: The name 'galla' means splitting in Korean and is derived from its role in chromosome segregation.
messages: spindle

7227:Dmel CG31821
gene id: 7227:Dmel_CG31821
uniprot id: Q9VJN0
names: Similarity
messages: Belongs to the peptidase S10 family.

7227:Dmel CG11537
gene id: 7227:Dmel_CG11537
uniprot id: M9NDY4
uniprot id: Q6NLL3
uniprot id: Q8T014
uniprot id: Q9VZU9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4062
gene id: 7227:Dmel_CG4062
uniprot id: A0A0B4KF06
uniprot id: Q0E993
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG9734
gene id: 7227:Dmel_CG9734
uniprot id: Q9VF15
names: Similarity
messages: Belongs to the globin family.

7227:Dmel CG5504
gene id: 7227:Dmel_CG5504
uniprot id: Q27237
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed throughout development, highest expression in first and second instar larvae and adults.
messages: In strains Harvich and Apxo, there are 2 identical genes which code for l(2)tid protein.
messages: May act as a tumor suppressor in larval imaginal disks.
messages: Mitochondrion outer membrane
messages: Ubiquitously expressed throughout embryonic development. In larvae, expression is seen in sensory organs, gopplet cells, gonads, imaginal disks, proventriculus, fat body, hematopoietic organ, midgut, Malpighian tubules and ring gland.

7227:Dmel CG10108
gene id: 7227:Dmel_CG10108
uniprot id: Q27934
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by the Ras1/MAPK pathway in R1, R6 and R7 cells in the eye. Down-regulated by the Notch pathway.
messages: Component of some E3 complex at least composed of sina, ebi and phyl, required for the degradation of ttk.
messages: Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk. Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells.
messages: Expressed both maternally and zygotically.
messages: In embryos, it is ubiquitously present before cellularization. During stages 9-11, it is expressed in neuroblasts and the SOP cells. From stage 12 onward, it decreases, but remains in a subset of PNS cells at stages 12-14. Weakly expressed in wing imaginal disks, in the SOP cells of wing margin bristles, notal macrochaetes, and other sensory organs. In leg disks, it is expressed in the precursors of the femoral chordotonal organs, as well as in external sensory SOP cells. Strongly expressed in the eye-antenna disk, it is specifically expressed in R1, R6 and R7 cells, and not in R3, R3, R4, R5 and R8 cells.
messages: Nucleus

7227:Dmel CG1104
gene id: 7227:Dmel_CG1104
uniprot id: A0A0B4K6K7
uniprot id: Q9VI55
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the UFL1 family.
messages: E3 UFM1-protein ligase that mediates ufmylation of target proteins.
messages: RNAi-mediated knockdown is lethal.

7227:Dmel CG5374
gene id: 7227:Dmel_CG5374
uniprot id: A4V391
uniprot id: P12613
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

7227:Dmel CG1100
gene id: 7227:Dmel_CG1100
uniprot id: Q9V3Z4
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

7227:Dmel CG8102
gene id: 7227:Dmel_CG8102
uniprot id: A1Z9Z6
uniprot id: A1Z9Z7
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

7227:Dmel CG42670
gene id: 7227:Dmel_CG42670
uniprot id: A0A0B4KGY6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the central nervous system in mushroom body neurons (at protein level).
messages: Expressed in the salivary gland, anterior and posterior midgut primordia, the fully formed midgut, amnioserosa, malpighian tubules, several regions of the head, and in isolated cells along the germ band, which are likely to be hemocytes.
messages: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity). Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance (PubMed:28525754).
messages: In both embryo and larva, results in irregularly shaped salivary glands with bulges of variable sizes, leading to greater distances between neighboring nuclei and decreased apical secretion.
messages: Nucleus
messages: The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain.

7227:Dmel CG2718
gene id: 7227:Dmel_CG2718
uniprot id: E1JHQ1
uniprot id: P20477
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.
messages: Mitochondrion

7227:Dmel CG1667
gene id: 7227:Dmel_CG1667
uniprot id: A0A0B4LFY9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Expression is directly activated by Rel (Relish).
messages: Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:29934091, PubMed:29924997, PubMed:30119996, PubMed:33262294, PubMed:34261127, PubMed:34261128). Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L.monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (PubMed:29924997). Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGlr1 and cGlr2 in response to RNA virus in the cytosol (PubMed:34261127, PubMed:34261128). Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP (PubMed:34261127). Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish) (PubMed:34261127, PubMed:34261128). Activated in brain in response to Zika virus infection, leading to autophagy (PubMed:29934091).

7227:Dmel CG1736
gene id: 7227:Dmel_CG1736
uniprot id: Q9VA12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase T1A family.
messages: Nucleus
messages: Testis, prominent after meiosis II. After meiosis, predominantly localized to the haploid spermatid nuclei of the 64-cell cysts, remaining during the elongation and condensation of the spermatid nuclei. In mature, motile sperm, expression is seen exclusively in the sperm head.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG5130
gene id: 7227:Dmel_CG5130
uniprot id: Q9VPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7227:Dmel CG5970
gene id: 7227:Dmel_CG5970
uniprot id: Q7K284
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

7227:Dmel CG12284
gene id: 7227:Dmel_CG12284
uniprot id: M9PI74
uniprot id: Q24306
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.
messages: Belongs to the IAP family.
messages: Detected in wing disks (at protein level).
messages: Interacts (via BIR 2 domain) with Dronc (via residues 114-125). Rpr, hid and grim can outcompete Dronc for binding Diap1 therefore removing Diap1-mediated ubiquitination. Interacts (via BIR 2 domain) with HtrA2; this displaces any bound Dronc. Interacts with Strica (PubMed:11550090). The N-terminally cleaved form interacts with Ubr3 (via UBR-type zinc finger) (PubMed:25146930, PubMed:26383956); the interaction promotes the recruitment and uniquitination of substrate capases such as Dronc (PubMed:25146930).
messages: Ubiquitinated and degraded by HtrA2 in apoptotic cells; proteolytic cleavage at specific sites in the BIR domain linker region generating inactive fragments. Mutation of one site reduces but does not abolish cleavage as another site is selected by the protease.

7227:Dmel CG9960
gene id: 7227:Dmel_CG9960
uniprot id: Q9VQF8
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

7227:Dmel CG14575
gene id: 7227:Dmel_CG14575
uniprot id: M9PFX5
uniprot id: Q8ITC7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed weakly in 16-24 hours embryos and second instar larvae and strongly in first and third instar larvae and adults.
messages: In adults, expression in thorax and/or abdomen.
messages: Membrane

7227:Dmel CG17166
gene id: 7227:Dmel_CG17166
uniprot id: Q9VUJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL39 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG4746
gene id: 7227:Dmel_CG4746
uniprot id: Q9U3W6
names: Caution
names: Similarity
messages: Belongs to the mab-21 family.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.

7227:Dmel CG4627
gene id: 7227:Dmel_CG4627
uniprot id: Q059A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

7227:Dmel CG8994
gene id: 7227:Dmel_CG8994
uniprot id: P28750
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the osk RNP complex, which is composed of at least exuperantia (exu), ypsilon schachtel (yps), aret (bruno), cup, and the mRNA of osk (PubMed:10662770). In the sponge body, forms a ribonucleoprotein complex (RNP) containing at least me31B, exu, yps and the mRNA of osk; interactions with exu and yps are RNA dependent (PubMed:11546740).
messages: Cytoplasmic ribonucleoprotein granule
messages: Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA.
messages: Expressed in stage 6 egg chambers.

7227:Dmel CG11062
gene id: 7227:Dmel_CG11062
uniprot id: O61643
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.
messages: Development of larvae with small brains and aberrant photoreceptor axon targeting.
messages: Expressed in embryonic, larval and adult stages.
messages: Homodimer or heterodimer; disulfide-linked.
messages: Secreted
messages: Widely expressed in larval brains.

7227:Dmel CG7972
gene id: 7227:Dmel_CG7972
uniprot id: Q9VSE2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Chromosome
messages: Impaired meiosis, leading to maternal mutants with eggshell defects (PubMed:9362456, PubMed:16888338). Mutant females produce ventralized egg shells, with phenotypes ranging from fused dorsal appendages to fully ventralized eggs with no dorsal appendages (PubMed:16888338). Mutant flies are hypersensitive to chemical mutagens (PubMed:16888338).
messages: Nucleus
messages: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:16888338). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity).

7227:Dmel CG5353
gene id: 7227:Dmel_CG5353
uniprot id: Q8IP94
uniprot id: Q9VKB0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7227:Dmel CG17657
gene id: 7227:Dmel_CG17657
uniprot id: M9PBR4
uniprot id: M9PE00
uniprot id: Q9VQ36
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Expressed during embryogenesis mainly in embryonic epidermis.
messages: Membrane
messages: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Functions cell autonomously to regulate wing cell hair polarity and number.
messages: cilium axoneme

7227:Dmel CG6690
gene id: 7227:Dmel_CG6690
uniprot id: Q9VD62
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

7227:Dmel CG1688
gene id: 7227:Dmel_CG1688
uniprot id: Q7KMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG12715
gene id: 7227:Dmel_CG12715
uniprot id: Q9VYH4
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7227:Dmel CG32022
gene id: 7227:Dmel_CG32022
uniprot id: Q8T481
names: Similarity
messages: Belongs to the WRB/GET1 family.

7227:Dmel CG33879
gene id: 7227:Dmel_CG33879
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG1063
gene id: 7227:Dmel_CG1063
uniprot id: A0A0B4LGN1
uniprot id: P29993
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Isoform A is expressed only in early embryos. Isoform B is expressed from mid-late embryos to adults. Predominant expression is in the adult.
messages: Membrane
messages: RNAi-mediated knockdown in the perineurial glia results in decreased ethanol tolerance following repeated ethanol exposure (PubMed:29444420). RNAi-mediated knockdown in muscle reduces mitochondrial calcium uptake (PubMed:28726639).
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:1322910). Together with MCU, has a role in oxidative stress-induced ER-mitochondria calcium transfer (PubMed:28726639). May be involved in visual and olfactory transduction, and myoblast proliferation (PubMed:1322910). May be involved in ethanol tolerance (PubMed:29444420).
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: Segmental expression of isoform B is first detected in stage 13 embryos in lateral and posterior epidermis. Expression extends to head region during stages 13-17: gnathal buds, clypeolabrum, procephalic lobe, labial organ and anterior sense organs. Adults exhibit high expression in antenna and lower expression in retina, head, legs and thorax.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

7227:Dmel CG9140
gene id: 7227:Dmel_CG9140
uniprot id: Q9VMI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

7227:Dmel CG11864
gene id: 7227:Dmel_CG11864
uniprot id: Q9VJN9
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Loss of cleavage of accessory gland proteins Acp26Aa and Acp36DE in females mated with mutant males (PubMed:24514904). RNAi-mediated knockdown in males results in incomplete and delayed processing of Acp26Aa and Acp36DE in females mated with these males.
messages: Produced in the male accessory glands and secreted into seminal fluid. In mated females, confined to the reproductive tract and also detected in eggs laid by mated females (at protein level).
messages: Secreted
messages: Seminal fluid metalloprotease which is transferred to females during mating and is required for processing of two other seminal fluid proteins Acp26Aa and Acp36DE in mated females.
messages: Undergoes cleavage in the male during mating with a cleaved product detected in the ejaculatory duct and/or bulb of males by 8-10 minutes after the start of mating (PubMed:17116868). Further cleavage occurs in the mated female (PubMed:15979005). May undergo cleavage in a two-step process where it is first cleaved by Sems, making it susceptible to activational cleavage which may be carried out by another protease or by autocleavage (PubMed:24514904).

7227:Dmel CG9115
gene id: 7227:Dmel_CG9115
uniprot id: Q9VMI9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7227:Dmel CG11793
gene id: 7227:Dmel_CG11793
uniprot id: P61851
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

7227:Dmel CG1762
gene id: 7227:Dmel_CG1762
uniprot id: A0A0S0WGT1
uniprot id: Q27591
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin beta chain family.
messages: Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.
messages: Expressed throughout development. Highest expression occurs during 12-15 hours of embryonic development (at protein level).
messages: Expression is confined to the developing midgut endoderm and its precursors during embryogenesis. In the larvae, expression is concentrated in the midgut imaginal disks. Expressed in embryonic and larval hemocytes (at protein level).
messages: Heterodimer of an alpha and a beta subunit. Interacts with scb/alpha-PS3.
messages: Homozygous mutant flies are viable and fertile. Mutant embryos show reduced level of phagocytosis, but normal level of hemocytes or apoptosis. At NMJ, mutant larvae show normal patterns of synaptic proteins but increased branch length, bouton number and quantal content in basal synaptic transmission recording.
messages: Membrane

7227:Dmel CG7595
gene id: 7227:Dmel_CG7595
uniprot id: G7H829
uniprot id: Q9V3Z6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Expressed in the setae, micro- and macrochaetae on the head, thorax and wing.
messages: Flies exhibit altered morphology of setae, micro- and macrochaetae on the head, thorax and wing (PubMed:15579689). The number and distribution of setae on the thorax is altered, as is the morphology of the aristae (PubMed:15579689). Mutants also exhibit scolopidial apical detachment and overall Johnston's organ (JO) disorganization (PubMed:15579689). RNAi-mediated knockdown in Johnston's organs, disrupts the filamentous structure of the glycoprotein NompA at the apical junction (PubMed:27331610). NompA occurs as puncta and scolopidia detatch from the hinge of the second and third antennal segment (PubMed:27331610).
messages: Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).
messages: Myosins are actin-based motor molecules with ATPase activity (PubMed:16585515). Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter (PubMed:16585515). A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments (PubMed:16585515). Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (PubMed:15579689). Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability (PubMed:15579689, PubMed:16585515). Necessary for auditory transduction: plays a role in Johnston's organ organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (PubMed:15886106, PubMed:27331610). Interaction with the myosin zip may be important for its function in scolopidial apical attachment (PubMed:27331610). During oogenesis it has Cad99c-dependent and Cad99c-independent roles in regulating the shape and spacing of the follicle cell microvilli which secrete eggshell material such as the vitelline membrane (PubMed:25236597). May be required for the normal expression of Cad99c in the follicle cell microvilli (PubMed:25236597).
messages: Throughout oogenesis expressed in the germline and associated somatic cells (at protein level) (PubMed:25236597). In germline cells of the germarium, expression levels peak during follicle formation and again from mid-oogenesis until late oogenesis (at protein level). Expressed both maternally and zygotically (PubMed:15579689). Expression peaks in 12-18 hour embryos, and continues at a constant low level of expression through to adults (PubMed:15579689).
messages: cell cortex
messages: microvillus

7227:Dmel CG18363
gene id: 7227:Dmel_CG18363
uniprot id: M9PFM0
uniprot id: Q9VVS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG8194
gene id: 7227:Dmel_CG8194
uniprot id: Q9VSC3
names: Similarity
messages: Belongs to the RNase T2 family.

7227:Dmel CG42731
gene id: 7227:Dmel_CG42731
uniprot id: Q9VMH0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tectonic family.
messages: Expressed in chordotonal neurons in the antennae and male germ cells (at protein level).
messages: Membrane
messages: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273).
messages: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
messages: Simultaneous knockout of B9d2 and tctn is viable and does not show sensory behavioral defects (PubMed:27646273). Males produce motile sperm and show only slightly reduced fertility (PubMed:27646273). Sperm flagella show weak ultrastructural defects including broken and disorganised structure (PubMed:27646273). Length of the transition zone is decreased and recruitment of the tectonic-like complex compromised (PubMed:27646273).
messages: centriole
messages: cilium basal body

7227:Dmel CG4162
gene id: 7227:Dmel_CG4162
uniprot id: Q9V3F2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

7227:Dmel CG8320
gene id: 7227:Dmel_CG8320
uniprot id: A1ZA77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

7227:Dmel CG11423
gene id: 7227:Dmel_CG11423
uniprot id: A1ZAW7
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

7227:Dmel CG7670
gene id: 7227:Dmel_CG7670
uniprot id: Q9VE86
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRNexo family.
messages: Females are sterile. Hypersensitive to the topoisomerase I inhibitor camptothecin. Highly elevated rates of mitotic DNA recombination resulting from excessive reciprocal exchange.
messages: Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (PubMed:18346216, PubMed:18056975, PubMed:18956248). Essential for the formation of DNA replication focal centers (PubMed:18346216, PubMed:18956248). Has an important role in maintaining genome stability (PubMed:18346216, PubMed:18956248).
messages: Nucleus

7227:Dmel CG42699
gene id: 7227:Dmel_CG42699
uniprot id: Q9W474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

7227:Dmel CG8175
gene id: 7227:Dmel_CG8175
uniprot id: Q24395
names: Developmental Stage
names: Function
names: Induction
names: Polymorphism
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection (at protein level) (PubMed:9736738). Up-regulated in hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks (at protein level) (PubMed:9736738).
messages: Expressed rapidly and strongly at all stages.
messages: Hemolymph (at protein level) (PubMed:9736738). Highest expression in fat body (PubMed:7588819).
messages: Potent antifungal and antibacterial activity against Gram-positive bacteria.
messages: Secreted
messages: There are 2 allelic forms (A1 and A2) varying in two positions. The isoform shown here is A1.

7227:Dmel CG34402
gene id: 7227:Dmel_CG34402
uniprot id: A8JQY3
uniprot id: Q15KK8
uniprot id: Q4V495
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3290
gene id: 7227:Dmel_CG3290
uniprot id: Q9W274
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG9745
gene id: 7227:Dmel_CG9745
uniprot id: P22058
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Chromosome
messages: D1 may be the most abundant member of a small family of D1-like proteins.
messages: Nucleus
messages: This satellite DNA-associated protein is a double-stranded DNA binding protein specific for tracts of pure at DNA. It may play a role in organizing the higher-order structure of euchromatin as well as heterochromatin.

7227:Dmel CG9165
gene id: 7227:Dmel_CG9165
uniprot id: Q9W0G4
names: Similarity
messages: Belongs to the HMBS family.

7227:Dmel CG3466
gene id: 7227:Dmel_CG3466
uniprot id: Q27589
uniprot id: X2JI29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG14750
gene id: 7227:Dmel_CG14750
uniprot id: Q7JXV9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS25 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be involved in the regulation of autophagy. ESCRT-II interacts with bicoid mRNA, which is required for the anterior localization of bicoid mRNA in the developing egg.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II) (By similarity). Interacts with Lsn/Snf8/Vps22 (Probable).
messages: Cytoplasm
messages: Endosome membrane
messages: Vps25 mutant cells exhibit multivesicular body sorting defects, with large amounts of ubiquitinated proteins detected on endosomes. This leads to activation of signals (through Notch and Dpp receptors) that drive cell proliferation, non-autonomous overgrowth, loss of epithelial organization, and render cells sensitive to apoptosis. Vps25 mutant cells display accumulation of autophagosomes. Bicoid mRNA is mislocalized in developing eggs.

7227:Dmel CG7013
gene id: 7227:Dmel_CG7013
uniprot id: Q9XZ63
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ARMET family.
messages: Expressed both maternally and zygotically through all developmental stages.
messages: In stage 12, expression is seen in the stomodeum and the salivary gland primordia, and weakly in the mesoderm. From stage 13 onward, expression is in Garland cells, the outer wall of the proventriculus and salivary glands. Punctuate expression is also in the ventral nerve cord (VNC), specifically in eagle (eg)-positive cell body glia. Epidermal expression is seen at stage 15.
messages: Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels.
messages: Secreted
messages: Total loss of dopaminergic neurites and drastic reduction in dopamine levels followed by degeneration of axonal bundles in the embryonic central nervous system and subsequent nonapoptotic cell death. Also exhibits cuticular defects.

7227:Dmel CG32486
gene id: 7227:Dmel_CG32486
uniprot id: Q9VZV5
names: Similarity
messages: Belongs to the ZFTRAF1 family.

7227:Dmel CG15102
gene id: 7227:Dmel_CG15102
uniprot id: Q7KB18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Catalyzes juvenile hormone hydrolysis.
messages: Endoplasmic reticulum membrane

7227:Dmel CG2818
gene id: 7227:Dmel_CG2818
uniprot id: Q9VQU3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7227:Dmel CG15377
gene id: 7227:Dmel_CG15377
uniprot id: P81911
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Not expressed in either the antenna or maxillary palp.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG6395
gene id: 7227:Dmel_CG6395
uniprot id: Q03751
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in wide range of synaptic terminals: embryonic nervous system, larval neuromuscular junctions, adult visual system (neuropil of optic ganglia and terminal of R1-8 photoreceptors) and thoracic neuromuscular junctions. Also expressed in non-neuronal cells: follicle cells, spermatheca, testis and ejaculatory bulb. Low level of expression is found in many neuronal and non-neuronal tissues.
messages: Fatty acylated. Heavily palmitoylated in the cysteine string motif.
messages: May have an important role in presynaptic function.
messages: Membrane

7227:Dmel CG17029
gene id: 7227:Dmel_CG17029
uniprot id: Q9VUW2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG42500
gene id: 7227:Dmel_CG42500
uniprot id: Q9VFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bomanin family.
messages: Secreted

7227:Dmel CG9521
gene id: 7227:Dmel_CG9521
uniprot id: Q9VY10
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG10728
gene id: 7227:Dmel_CG10728
uniprot id: Q9VIP8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Abundant in ovaries, early embryos and adult females, but reduced in adult males.
messages: In oocytes, localizes to pole plasm and nuage (at protein level). Expressed stronger in the germline than in somatic cells. In the germarium it sometimes concentrates in perinuclear aggregates that disappear by stage 2 of oogenesis. At later stages, it is uniformly distributed in the nurse cells and oocyte, as well as in young embryos, with no particular enrichment at the posterior or inside the pole cells (at protein level).
messages: Interacts with csul and tud.
messages: Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul.

7227:Dmel CG31105
gene id: 7227:Dmel_CG31105
uniprot id: A0A0B4K6G4
uniprot id: Q8IMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG17919
gene id: 7227:Dmel_CG17919
uniprot id: Q9VI09
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

7227:Dmel CG12275
gene id: 7227:Dmel_CG12275
uniprot id: Q9VB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Cytoplasm

7227:Dmel CG12373
gene id: 7227:Dmel_CG12373
uniprot id: Q7JVK1
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

7227:Dmel CG30295
gene id: 7227:Dmel_CG30295
uniprot id: A0A0B4KEV9
uniprot id: A0A0B4LH15
uniprot id: A8DYK1
uniprot id: Q9W2Q7
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Contributes to the formation of Ins(1,2,3,4,5,6)P6 (InsP6, IP6 or phytate) (PubMed:15322119). Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form InsP6 (Probable). Together with Ipk2, they are the main contributors to higher InsP synthesis (PubMed:15322119).
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

7227:Dmel CG5786
gene id: 7227:Dmel_CG5786
uniprot id: Q9VDE5
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the PPAN family.
messages: Expressed both maternally and zygotically, highest expression level is during embryogenesis.
messages: Required for initiation of larval growth and normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Required for progression of normal oogenesis and maturation of some imaginal tissues into adult structures.
messages: Ubiquitous.

7227:Dmel CG3938
gene id: 7227:Dmel_CG3938
uniprot id: A4V0R4
uniprot id: M9NDQ2
uniprot id: P54733
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin E subfamily.
messages: Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.
messages: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex (PubMed:11565033). The cyclin subunit imparts substrate specificity to the complex (PubMed:11565033). Interacts (via C-terminus) with Z600 (via C-terminus) (PubMed:17431409).
messages: Isoform II is expressed maternally and isoform I zygotically in larvae.
messages: Isoform II is ubiquitous in early embryos and, prior to mitosis 14, is rapidly degraded in all cells except the pole (germ) cells. Expressed during G1 phase in proliferating peripheral nervous system cells. Constitutive expression in embryonic cycles lacking a G1 phase.
messages: Nucleus

7227:Dmel CG8971
gene id: 7227:Dmel_CG8971
uniprot id: Q9W385
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the frataxin family.
messages: Expressed throughout development, levels are high during embryogenesis but low in following stages.
messages: Mitochondrion
messages: Monomer (probable predominant form) (PubMed:18540637). Oligomer (PubMed:18540637). Might form a complex with bcn92, IscU and Nsf1 (Probable). Interacts with IscU (By similarity).
messages: Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:18540637). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:18540637). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:18540637). Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition (PubMed:25628335).
messages: RNAi-mediated knockdown results in nearly absent pupariation and reduced ecdysteroid peak level required to proceed to pupal stage (PubMed:25628335). RNAi-mediated knockdown in the prothoracic gland results in delayed or absent pupariation (PubMed:25628335).

7227:Dmel CG15116
gene id: 7227:Dmel_CG15116
uniprot id: Q4V6H2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7227:Dmel CG9359
gene id: 7227:Dmel_CG9359
uniprot id: P61857
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Testis specific.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7227:Dmel CG10320
gene id: 7227:Dmel_CG10320
uniprot id: Q9W2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

7227:Dmel CG17291
gene id: 7227:Dmel_CG17291
uniprot id: P36179
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase 2A regulatory subunit A family.
messages: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
messages: Expressed both maternally and zygotically. Expressed at lower levels in larvae and adult.
messages: Expression varies in tissues throughout development. Highly distributed expression in early embryos. In late embryonal development, found at high levels in nervous system and gonads. In third instar larvae, found in brain, imaginal disks and salivary glands.
messages: Intron retention.
messages: PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme.
messages: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

7227:Dmel CG8912
gene id: 7227:Dmel_CG8912
uniprot id: A1ZAK7
uniprot id: A1ZAK8
uniprot id: A1ZAK9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG15224
gene id: 7227:Dmel_CG15224
uniprot id: A4V4C1
uniprot id: M9NDU6
uniprot id: M9NGA3
uniprot id: M9PHA6
uniprot id: P08182
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
messages: Phosphorylated by alpha subunit.
messages: Tetramer of two alpha and two beta subunits.

7227:Dmel CG5220
gene id: 7227:Dmel_CG5220
uniprot id: Q9VEP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

7227:Dmel CG14641
gene id: 7227:Dmel_CG14641
uniprot id: Q95RB1
names: Similarity
messages: Belongs to the SLT11 family.

7227:Dmel CG11679
gene id: 7227:Dmel_CG11679
uniprot id: Q9VXQ8
names: Similarity
messages: Belongs to the RMD1/sif2 family.

7227:Dmel CG31449
gene id: 7227:Dmel_CG31449
uniprot id: C7LA76
uniprot id: Q8INI8
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
messages: Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

7227:Dmel CG6976
gene id: 7227:Dmel_CG6976
uniprot id: Q8IPH6
uniprot id: Q8IPH7
uniprot id: Q8IPH8
uniprot id: Q9VLZ3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7227:Dmel CG4239
gene id: 7227:Dmel_CG4239
uniprot id: Q9VXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane

7227:Dmel CG33513
gene id: 7227:Dmel_CG33513
uniprot id: E1JJC6
uniprot id: Q6IWN7
uniprot id: Q8MM14
uniprot id: Q9W581
uniprot id: X2JDW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG3985
gene id: 7227:Dmel_CG3985
uniprot id: E2QCY9
uniprot id: E2QCZ0
uniprot id: Q24546
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synapsin family.
messages: Detected at all developmental stages after mid-embryogenesis.
messages: Identified in a complex with Syt1 and nwk.
messages: Mutants show no obvious defects in brain morphology and no striking qualitative changes in behavior are observed. Quantitative differenes are seen: mutants show faster habituation of an olfactory jump response, enhanced ethanol tolerance, and significant defects in learning and memory as measured using three different paradigms.
messages: Plays a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behavior.
messages: Readthrough of the terminator UGA may occur between the codons for 581-Met and 583-Glu.
messages: Synapse
messages: Widely expressed in the embryonic and adult nervous system synaptic terminals.

7227:Dmel CG4461
gene id: 7227:Dmel_CG4461
uniprot id: Q9VSX2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG2914
gene id: 7227:Dmel_CG2914
uniprot id: A8DYS7
uniprot id: A8E758
uniprot id: P29776
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Embryonic ventral nervous system and 1 pair of neurons in each thoracic segment.
messages: Expressed throughout development.
messages: Nucleus

7227:Dmel CG2261
gene id: 7227:Dmel_CG2261
uniprot id: Q9V9V0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG40478
gene id: 7227:Dmel_CG40478
uniprot id: P83102
names: PTM
names: Sequence Caution
names: Similarity
messages: Autophosphorylated on tyrosine residues.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Intron retention.

7227:Dmel CG13472
gene id: 7227:Dmel_CG13472
uniprot id: Q9VUH8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

7227:Dmel CG6219
gene id: 7227:Dmel_CG6219
uniprot id: Q95RV2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds to chromosome ends in a sequence-dependent manner and is required for telomere capping.
messages: Death at the larval/pupal boundary due to extensive telomere-telomere fusions in larval brain cells.
messages: Expressed both maternally and zygotically.
messages: Interacts (via C-terminus) with Su(var)205 dimer (via hinge and chromoshadow domain) and with moi to form the terminin telomere-capping complex. Interacts with HP6, which is also part of the terminin complex.
messages: Multiple telomeric associations (TAs) in the same metaphase spread often result in multicentric linear chromosomes that resemble little 'trains' of chromosomes, hence the name 'caravaggio', an Italian train.
messages: Nucleus
messages: telomere

7227:Dmel CG9327
gene id: 7227:Dmel_CG9327
uniprot id: P18053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG11956
gene id: 7227:Dmel_CG11956
uniprot id: Q0KI00
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG6859
gene id: 7227:Dmel_CG6859
uniprot id: Q9VUL8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

7227:Dmel CG9470
gene id: 7227:Dmel_CG9470
uniprot id: A0A0B4KFM8
uniprot id: P04357
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 5 family.
messages: Late embryogenesis, larva and adult.
messages: Strongly induced by cadmium, copper and mercury.
messages: This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

7227:Dmel CG4993
gene id: 7227:Dmel_CG4993
uniprot id: O61722
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apicolateral cell membrane
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Compartment-specific localization and function depends on long untranslated sequences (UTR) in the PRL-1 mRNA.
messages: Cytoplasm
messages: Expressed in the adult head (at protein level) (PubMed:31404830). Expressed in neurons in the antennal lobe and V-glomeruli (at protein level) (PubMed:31404830). Expressed in dorsocentral neurons (at protein level) (PubMed:31048465).
messages: Expressed ubiquitously during embryogenesis and larval development (at protein level) (PubMed:23577193). Expressed in wing disks and developing eyes in both actively dividing cells (anterior to the morphogenetic furrow) and differentiated cells (posterior to the morphogenetic furrow) (at protein level) (PubMed:23577193).
messages: Homotrimer (By similarity). Interacts with uex, possibly at the plasma membrane (PubMed:31404830).
messages: Probable phosphatase (Probable). Inhibits growth possibly by negatively regulating Src64B-induced growth (PubMed:23577193). Regulates central nervous system circuit formation and stabilization of synapse-dense terminal arbors (PubMed:31048465). In dorsocentral neurons, regulates synaptogenesis in terminal arbors via modulation of the insulin receptor pathway, likely upstream of Akt1, and via reduction of PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) levels (PubMed:31048465). In the nervous system, plays a protective role together with uex in response to olfactory carbon dioxide stimulation (PubMed:31404830).
messages: Viable (PubMed:31404830, PubMed:31048465). Results in delayed hatching, locomotor defects and inability to fly (PubMed:31048465). Results in defects in axonal target areas in several central nervous system circuits (PubMed:31048465). Results in axonal and synapses defects in two distinct brain neuropils in the antennal lobes and mushroom bodies, respectively related to olfaction and olfaction-associated learning (PubMed:31048465). Reduces size of the central nervous system neuropil (a region of densely packed axons, dendrites, and synapses) (PubMed:31048465). When exposed to high concentration of carbon dioxide treatment results in a vertical held-up wing phenotype with calcium hyperactivation of neurons in the antennal lobe (PubMed:31404830, PubMed:31048465). Results in loss of synaptic arborizations from the contralateral mechanosensory neuron axon collateral with no defect in morphology (PubMed:31048465). RNAi-mediated knockdown in mechanosensory neurons eliminates terminal arbors and reduces numbers of synapses in the contralateral projecting axon collateral (PubMed:31048465).
messages: axon

7227:Dmel CG6151
gene id: 7227:Dmel_CG6151
uniprot id: D8FT42
uniprot id: F0JAK1
uniprot id: Q95T12
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis. Isoform A and isoform B are mainly required in the nervous system and necessary in photoreceptor cells.
messages: Belongs to the calcium channel flower family.
messages: Homomultimer; Isoform B.
messages: Impaired intracellular resting calcium levels and impaired endocytosis in presynaptic terminals, exocytosis is normal. Mutant boutons at the neuromuscular junctions exhibit a significant depletion in the number of synaptic vesicles. There are numerous extra boutons which are often small, clustered, and flowery in nature. Mutant nerve terminals display omega structures and collared pits.
messages: Isoform B is expressed in the neuropils of embryonic, larval, adult CNS, and R1-R6 terminals. Expression in the central nervous system (CNS) starts at embryonic stage 13.
messages: Membrane
messages: synaptic vesicle membrane

7227:Dmel CG5048
gene id: 7227:Dmel_CG5048
uniprot id: Q9VUG3
names: Similarity
messages: Belongs to the PIH1 family.

7227:Dmel CG10250
gene id: 7227:Dmel_CG10250
uniprot id: P22816
uniprot id: Q4V6U8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Initially localized to segmentally repeated clusters of mesodermal cells, and subsequently in at least a subset of growing muscle precursors and mature muscle fibers that exhibit distinct segmental differences.
messages: May play an important role in the early development of muscle.
messages: Nucleus

7227:Dmel CG5463
gene id: 7227:Dmel_CG5463
uniprot id: Q9VCD0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7227:Dmel CG33338
gene id: 7227:Dmel_CG33338
uniprot id: P83100
names: Function
names: PTM
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Kinase involved in a signal transduction pathway.
messages: The phosphorylation on Thr-177 activates the enzyme (By similarity). A conserved Tyr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by His-179 in this sequence.

7227:Dmel CG6875
gene id: 7227:Dmel_CG6875
uniprot id: H0RNM3
uniprot id: Q9VC45
names: Developmental Stage
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed both maternally and zygotically in embryos.
messages: Intron retention.
messages: Nucleus
messages: Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation.
messages: spindle

7227:Dmel CG7772
gene id: 7227:Dmel_CG7772
uniprot id: Q9VX02
names: Similarity
messages: Belongs to the MTFP1 family.

7227:Dmel CG1644
gene id: 7227:Dmel_CG1644
uniprot id: Q9VRI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG7280
gene id: 7227:Dmel_CG7280
uniprot id: Q9VWP4
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Expressed in the ensheathing glia with relatively weak expression in the CNS cortex (at protein level).
messages: It is not obvious if the molybdenum-pterin domain is functional; the conserved cysteine (position 339) is replaced by an isoleucine.
messages: Mitochondrion intermembrane space
messages: Named 'shopper' because of the mutant locomotion phenotype in which larvae stop and bend their heads more frequently.
messages: RNAi-mediated knockdown in larvae results in reduced levels of sulfite oxidase activity. RNAi-mediated knockdown in ensheathing glial cells results in larval locamotion defects, including reduced run phases with more stops and an increase in head bending frequency. RNAi-mediated knockdown in the cortex glia, astrocytes or neurons has no effect on locomotion or head bending frequency.
messages: Required in ensheathing glial cells for normal larval locomotion. Oxidizes sulfite which is required to maintain glutamate homeostasis and as a consequence, neuronal network function.

7227:Dmel CG1877
gene id: 7227:Dmel_CG1877
uniprot id: Q24311
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cullin family.
messages: Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larval neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (PubMed:20392747). Interacts directly with Roc1a (PubMed:11500045). Interacts with Fsn (PubMed:20123973). Interacts with Dlish (PubMed:27692068). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:27331610). Interacts with Sans (PubMed:27331610).
messages: Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747). Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment (PubMed:27331610). May function by acting in a Ubr3-mediated pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck (PubMed:27331610).
messages: Cytoplasm
messages: Expressed in testis.
messages: Neddylated (PubMed:12183637, PubMed:18493598). Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:12183637).
messages: Severe dendrite pruning defects in ddaC neurons at 16 hours after puparium formation (APF) and axon pruning defects in mushroom body gamma neurons at 24 hours APF. RNAi-mediated knockdown results in a significant increase in Akt1 protein levels and activity in ddaC somas (PubMed:24068890). In the larval brain there is a large increase in the number of neuroblasts, 40% of which show a spindle misorientation at metaphase (PubMed:24413555). RNAi-mediated knockdown results in apical detachment of scolopidial cells in Johnston's organ (PubMed:27331610).

7227:Dmel CG7476
gene id: 7227:Dmel_CG7476
uniprot id: Q9VSE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG33105
gene id: 7227:Dmel_CG33105
uniprot id: Q86BA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

7227:Dmel CG2972
gene id: 7227:Dmel_CG2972
uniprot id: Q9W2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

7227:Dmel CG32178
gene id: 7227:Dmel_CG32178
uniprot id: Q0E8D8
uniprot id: Q8IQR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7227:Dmel CG2979
gene id: 7227:Dmel_CG2979
uniprot id: P02844
uniprot id: X2JB25
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: By beta-ecdysone; in males.
messages: Expressed during late pupal development and in adult females between days 1-3.
messages: Secreted
messages: Synthesized in the fat body and ovarian follicle cells and accumulate in the oocyte.
messages: Tyrosine sulfation occurs in the female only and plays an essential functional role.
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG8442
gene id: 7227:Dmel_CG8442
uniprot id: Q03445
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Central nervous system.
messages: Homooligomer.
messages: No expression is seen in early embryogenesis, whereas high expression occurs in late embryos. During larval development, expression decreases to undetectable levels in late larvae, resumes at the early pupal stage and gradually increases in late pupae and early adult flies. High levels of expression coincide with major stages of neurogenesis.
messages: Postsynaptic cell membrane
messages: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate.

7227:Dmel CG33517
gene id: 7227:Dmel_CG33517
uniprot id: Q8IS44
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in larva, pupae and adult.
messages: Highest expression is in adult heads.
messages: Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

7227:Dmel CG4426
gene id: 7227:Dmel_CG4426
uniprot id: Q9VPW1
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the asteroid family.
messages: Expressed at higher levels during the embryonic and pupal stages of development. Expressed in proliferating tissues of the presumptive mesoderm in stage 7 gastrulating embryos. Expressed in the mesectoderm and anterior and posterior midgut primordia of stage 9 embryos. Also expressed in proliferating cells of the central nervous system during germ-band retraction.
messages: Expressed in the proliferative tissues of embryos and in the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal disks.
messages: May function in EGF receptor signaling. May play a role in compound eye morphogenesis.

7227:Dmel CG9770
gene id: 7227:Dmel_CG9770
uniprot id: Q9VHN9
uniprot id: U3PV63
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the HPS5 family.
messages: Expressed in eye pigment granules.
messages: Expressed throughout development, highest expression being in adult heads.
messages: Flies exhibit defects in vesicular transport to lysosomes and therefore can alter eye color.
messages: Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes.
messages: Pink was the second eye color gene identified by Morgan and colleagues, mutant flies were isolated in June 1910 just 2 months after isolation of the first white mutant allele. Another mutant allele of pink, peach, was isolated by Bridges in 1913, and according to a review published by Bridges and Morgan 10 years later, these alleles represented the first case of multiple allelomorphs described for an autosomal gene in Drosophila.

7227:Dmel CG1692
gene id: 7227:Dmel_CG1692
uniprot id: Q9VRA2
uniprot id: X2JFY7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

7227:Dmel CG3689
gene id: 7227:Dmel_CG3689
uniprot id: Q0E8G6
uniprot id: Q9VSY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

7227:Dmel CG6339
gene id: 7227:Dmel_CG6339
uniprot id: A0A0B4K7L0
uniprot id: Q9W252
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Chromosome
messages: Death during pupal stage, possibly due to the accumulation of DNA DSBs and the induction of apoptosis in third instar larvae.
messages: Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair. The complex participates in processes such as DNA recombination, DNA repair, genome stability, telomere integrity and meiosis. The MRN complex may protect telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.
messages: Homodimer. Probable component of the MRN complex with mre11 (By similarity).
messages: Nucleus
messages: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).
messages: telomere

7227:Dmel CG11924
gene id: 7227:Dmel_CG11924
uniprot id: P20385
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Contaminating sequence. Potential poly-A sequence.
messages: Isoform I is found in embryos, pupae and adult somatic tissue; isoform II occurs in embryos, pupae, ovaries, testis and to a lesser extent in adult somatic tissue.
messages: Nucleus
messages: Transcriptional regulator; binds to the promoter region of Cp15. Also binds to its own promoter, thus having a probable autoregulatory role.

7227:Dmel CG6666
gene id: 7227:Dmel_CG6666
uniprot id: Q9VGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b560 family.
messages: Membrane

7227:Dmel CG9336
gene id: 7227:Dmel_CG9336
uniprot id: M9NEV7
uniprot id: Q9VII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG7740
gene id: 7227:Dmel_CG7740
uniprot id: M9PDX6
uniprot id: M9PH44
uniprot id: P82295
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Intron retention.
messages: Membrane

7227:Dmel CG6011
gene id: 7227:Dmel_CG6011
uniprot id: Q9V437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

7227:Dmel CG12753
gene id: 7227:Dmel_CG12753
uniprot id: A0A0B4KH88
uniprot id: Q9VEV4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLEC16A/gop-1 family.
messages: Golgi apparatus membrane
messages: Interacts with the class C Vps-HOPS complex components; Car, Dor and Vps16a.
messages: Late endosome membrane
messages: Pupal lethal (PubMed:20194640). Larval neuromuscular junctions (NMJ) display an increase in synaptic bouton number and synaptic area (PubMed:20194640). In Garland cells endosome trafficking is impaired (PubMed:20194640). Early and late endosomes are unable to progress into mature degradative endosomes and lysosomes resulting in enlarged endosomal compartments (PubMed:20194640). In larvae, starvation-induced autophagosomes are significantly decreased in size (PubMed:22493244). However, autophagosomes are able to form and can mature via fusion with endosomes and lysosomes (PubMed:22493244).
messages: Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways (PubMed:20194640, PubMed:22493244). Required for endosome trafficking and maturation (PubMed:20194640). Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes (PubMed:20194640). In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy (PubMed:22493244). Essential for the recruitment of lva-positive Golgi elements to autophagosomes (PubMed:22493244). Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes (PubMed:22493244). Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling (PubMed:20194640).
messages: autophagosome membrane

7227:Dmel CG11335
gene id: 7227:Dmel_CG11335
uniprot id: Q9V9X5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG31048
gene id: 7227:Dmel_CG31048
uniprot id: A0A0B4KHD2
uniprot id: B7Z0R2
uniprot id: Q9VAS8
names: Similarity
messages: Belongs to the DOCK family.

7227:Dmel CG6105
gene id: 7227:Dmel_CG6105
uniprot id: Q9VKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

7227:Dmel CG17292
gene id: 7227:Dmel_CG17292
uniprot id: Q7K3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG9193
gene id: 7227:Dmel_CG9193
uniprot id: P17917
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PCNA family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed at high levels in adult ovary.
messages: Expressed maternally and zygotically (PubMed:1968224). Expressed at high levels in embryos at 0-2 and 8-12 h of development (PubMed:17087725, PubMed:1968224). Moderate levels detected at later stages of embryogenesis, in unfertilized eggs and adult females, and relatively low levels of expression were detected in larvae and adult males (PubMed:17087725).
messages: Homotrimer (PubMed:17087725). Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Interacts with E2f (PubMed:19081076). Interacts with the catalytic subunits of two DNA polymerase complexes: PolD1 from the delta complex and PolE1/DNApol-epsilon255 from the epsilon complex (PubMed:17087725).
messages: Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility.
messages: Mutant flies show temperature-sensitive lethality, hypersensitivity to DNA-damaging agents such as ionizing radiation and methyl methanesulfonate, suppression of position-effect variegation and female sterility.
messages: Nucleus

7227:Dmel CG1827
gene id: 7227:Dmel_CG1827
uniprot id: Q8MR45
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).
messages: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Intron retention.

7227:Dmel CG3050
gene id: 7227:Dmel_CG3050
uniprot id: Q9VFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG10988
gene id: 7227:Dmel_CG10988
uniprot id: Q9XYP8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin small complex (Gamma TuSC) is a heterotetrameric complex which contains two molecules of gamma-tubulin, and one molecule each of Dgrip84 and Dgrip91. The gamma-tubulin in this complex binds preferentially to GDP over GTP.
messages: centrosome

7227:Dmel CG1467
gene id: 7227:Dmel_CG1467
uniprot id: Q9VR90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

7227:Dmel CG14214
gene id: 7227:Dmel_CG14214
uniprot id: Q9VWE9
uniprot id: X2JCL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

7227:Dmel CG8548
gene id: 7227:Dmel_CG8548
uniprot id: O76521
names: Similarity
messages: Belongs to the importin alpha family.

7227:Dmel CG14743
gene id: 7227:Dmel_CG14743
uniprot id: A1Z7I2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6842
gene id: 7227:Dmel_CG6842
uniprot id: Q9Y162
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

7227:Dmel CG9118
gene id: 7227:Dmel_CG9118
uniprot id: P83972
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Found in the midgut.
messages: Maximal expression is found during the third larval instar, it drops to become undetectable in the late pupal stage. The expression in adults is similar to that of first and second larval instars.
messages: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.

7227:Dmel CG11315
gene id: 7227:Dmel_CG11315
uniprot id: Q8IMH5
uniprot id: Q9VA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

7227:Dmel CG12479
gene id: 7227:Dmel_CG12479
uniprot id: Q9VY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG3989
gene id: 7227:Dmel_CG3989
uniprot id: F0JAN1
uniprot id: Q9I7S8
names: Function
names: Similarity
names: Subunit
messages: Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

7227:Dmel CG3642
gene id: 7227:Dmel_CG3642
uniprot id: Q9VPT8
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160.
messages: During oogenesis, expression is detected in the germarium, in nurse cells, in the oocyte, and in the somatically derived follicular epithelial cells (at protein level). At oogenesis stage 12, nurse cells degenerate and their content is transferred into the oocyte. In larvae, expressed in all organs and disks (at protein level). In the larval salivary gland, expression is initially confined to cells at the anterior end but later expands throughout the entire gland (at protein level).
messages: Expressed both maternally and zygotically. During embryogenesis expressed only at transcript level. Expressed in larvae (at protein level), pupae and adults. Initial embryonic expression is maternally derived, then gradually decreases until third-instar larvae when there is a burst of zygotic expression. Most of the female expression is ovarian (at protein level).
messages: Nucleus
messages: The C-terminal region containing the two CCHC-type zinc fingers confers a binding preference for RNAs that contain G- and/or C-rich clusters.
messages: The N-terminal region containing the five C3H1-type zinc fingers is essential for endonuclease activity.

7227:Dmel CG5861
gene id: 7227:Dmel_CG5861
uniprot id: Q9V3I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG15696
gene id: 7227:Dmel_CG15696
uniprot id: Q9VDH9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG40411
gene id: 7227:Dmel_CG40411
uniprot id: P35875
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Expressed both maternally and zygotically in embryos, pupae and adults. Expression is highest in embryos.
messages: Expressed in adult female oocytes, anal plates of stage 12 embryos and in cells around the central nervous system in later embryos.
messages: Nucleus
messages: Plays a fundamental role in organizing chromatin on a global scale (PubMed:12183365). Autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment (PubMed:12183365).
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17827147). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of CG1218/HPF1 (By similarity). Following interaction with CG1218/HPF1, catalyzes serine ADP-ribosylation of target proteins; CG1218/HPF1 conferring serine specificity by completing the Parp active site (By similarity).
messages: nucleolus

7227:Dmel CG1954
gene id: 7227:Dmel_CG1954
uniprot id: A0A0B4LI13
uniprot id: P13678
uniprot id: Q4QQA3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
messages: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.

7227:Dmel CG8048
gene id: 7227:Dmel_CG8048
uniprot id: B7YZI0
uniprot id: Q9V7N5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase C subunit family.
messages: In larvae, expressed in the ring gland, CNS, imaginal disks and lymph gland.
messages: RNAi-mediated knockdown specifically in pHCl-2 expressing enterocytes delays pupariation and reduces food intake.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

7227:Dmel CG3827
gene id: 7227:Dmel_CG3827
uniprot id: P10084
names: Developmental Stage
names: Function
names: Subunit
names: Tissue Specificity
messages: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Interacts with da (via bHLH motif). Interacts with Bap60.
messages: Expressed zygotically in embryos from 0 to 12 hours after fertilization, with a peak of expression during the 2 to 4 hour period. Expression reappears in third instar larvae and pupae.
messages: L(1)SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe. Associates with the somatic nuclei through nuclear cycles 9 and 10. During nuclear cycle 11 distributes uniformly in the embryo.

7227:Dmel CG30108
gene id: 7227:Dmel_CG30108
uniprot id: A1ZAX2
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

7227:Dmel CG31961
gene id: 7227:Dmel_CG31961
uniprot id: Q95TP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

7227:Dmel CG15626
gene id: 7227:Dmel_CG15626
uniprot id: Q9VR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

7227:Dmel CG11715
gene id: 7227:Dmel_CG11715
uniprot id: Q8IR88
uniprot id: Q9VYY4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in larval brain cortex cells and ring glands and weakly in larval digestive system and adult nervous system.
messages: Expressed throughout development.
messages: Microsome membrane
messages: Probably involved in steroid hormones biosynthesis.

7227:Dmel CG1076
gene id: 7227:Dmel_CG1076
uniprot id: A0A0B4K626
uniprot id: Q9VNL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.

7227:Dmel CG42566
gene id: 7227:Dmel_CG42566
uniprot id: A8DYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG18519
gene id: 7227:Dmel_CG18519
uniprot id: Q8IND5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG9743
gene id: 7227:Dmel_CG9743
uniprot id: Q9VA92
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG1416
gene id: 7227:Dmel_CG1416
uniprot id: Q9V9Q4
names: Similarity
messages: Belongs to the AHA1 family.

7227:Dmel CG8806
gene id: 7227:Dmel_CG8806
uniprot id: A0A0B4KEN7
uniprot id: Q9V579
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed from the earliest stages of development, and is ubiquitous throughout embryonic development (PubMed:15700158). At stage 16, it is strongly up-regulated in the developing brain lobes, but not in the ventral nerve cord (PubMed:15700158). Also up-regulated in specific regions of the midgut (PubMed:15700158). Expressed during all subsequent developmental stages from first instar larvae through to adulthood (PubMed:15700158). In larvae, expressed in dendritic arborization (da) neurons, with highest levels of expression in class IV neurons compared to the other da classes (PubMed:19855018).
messages: Involved in maintaining the structural and functional integrity of mitochondria (PubMed:19855018). Activity is required for maintaining the subcellular distribution, shape and activity of mitochondria in neurons and as a consequence has an important role in the development and maintenance of dendritic arbors (PubMed:19855018). Function may be particularly important in class IV dendritic arborization (da) neurons (PubMed:19855018).
messages: Lethal at early larval stages.
messages: Mitochondrion
messages: Widely expressed.

7227:Dmel CG33526
gene id: 7227:Dmel_CG33526
uniprot id: Q7KU01
uniprot id: Q9VPU9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10955
gene id: 7227:Dmel_CG10955
uniprot id: Q9W261
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Death at pupal stage. Weaker mutants that live to adulthood exhibit reduced wing width.
messages: Detected in embryo. Expression is very low in larvae, pupae or adults.
messages: Interacts with the RNA polymerase II complex. May interact with the PAF1 complex.
messages: Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat-shock genes. Plays a role in Notch signaling in the wing margins.
messages: nucleoplasm

7227:Dmel CG1417
gene id: 7227:Dmel_CG1417
uniprot id: A4V4U5
uniprot id: M9NFJ2
uniprot id: M9NHG9
uniprot id: Q04499
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate (PubMed:8096642). Involved in the conversion of proline to glutamate, which functions as transmitter at neuromuscular junctions (PubMed:8096642). Glutamate deficiency could possibly account for reduced motor activity (PubMed:8096642).
messages: Converts proline to delta-1-pyrroline-5-carboxylate.
messages: Expressed in developing embryo as well as in adult.
messages: Flies exhibit reduced proline oxidase activity which produces sluggish behavior.
messages: Mitochondrion matrix
messages: Most abundant in developing nervous system.

7227:Dmel CG11176
gene id: 7227:Dmel_CG11176
uniprot id: Q9VYA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango2 family.
messages: Cytoplasm
messages: Golgi apparatus
messages: May play a role in Golgi organization.
messages: Mitochondrion

7227:Dmel CG6136
gene id: 7227:Dmel_CG6136
uniprot id: A0A0B4JDE8
uniprot id: Q9VF71
names: Function
names: Similarity
messages: Belongs to the CutC family.
messages: Involved in copper homeostasis.

7227:Dmel CG9659
gene id: 7227:Dmel_CG9659
uniprot id: O01346
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system.
messages: Membrane

7227:Dmel CG10247
gene id: 7227:Dmel_CG10247
uniprot id: Q9V774
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG12200
gene id: 7227:Dmel_CG12200
uniprot id: Q9VWI4
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in nurse cell and pro-oocytes (at protein level).
messages: May interact with itself, with nenya and vilya through its RING-type zinc finger.
messages: Nenya, narya and vilya contain a RING-type zinc finger domain and are named after the Three Rings of Power given by the elves of Eregion in J.R.R. Tolkien's books.
messages: Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process (PubMed:30615609). Plays a role in DSBs processing into crossovers (PubMed:30615609). Plays a redundant role with nenya in chromosome segregation during female meiosis (PubMed:30615609).

7227:Dmel CG3733
gene id: 7227:Dmel_CG3733
uniprot id: M9ND16
uniprot id: M9PEB2
uniprot id: Q7KU24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome (By similarity). Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromosome
messages: Component of the SAGA complex (By similarity). Interacts with SSRP1.
messages: Nucleus
messages: The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
messages: The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes.

7227:Dmel CG3409
gene id: 7227:Dmel_CG3409
uniprot id: Q8T043
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8667
gene id: 7227:Dmel_CG8667
uniprot id: B6VQA1
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Detected in the developing nervous system in the bilateral domains in the cephalic region that later on forms part of the ring gland. Concomitantly expressed in the larval central nervous system (CNS), including the dorsal chain neurons as well as several bilateral clusters of neurons: large, midline protocerebral brain cells (MC), lateral protocerebral brain cells (LC), ventral subesophageal neurons (SE) and lateral abdominal neurons, and the transverse nerves. Outside the CNS, detected in at least three classes of endocrine cells: intrinsic cells of the corpora cardiaca, midgut cells, the Inka cells, lateral Bipolar neurons associated with the segmental transverse nerve, and several peptidergic cells of the enteric nervous system. Expressed only in central and peripheral neuroendocrine secretory cells and neurosecretory neurons but not in sensory or motor neurons.
messages: First detected in the embryonic ectoderm at early stage 11, but this expression is transient. Zygotic expression is first detected in stage 12 embryos and cytoplasmic expression is detected in many cells around stage 14. Embryonic cells maintain expression throughout their lifetime and expression continues into hatchling larvae less than 24 hours old.
messages: Forms homodimers via the bHLH domain. These dimers bind the core E-box sequence.
messages: The basic domain binds to the canonical E-box (5'-CANNTG-3'), with a particular preference for TA relative to AT or CG in the variable central nucleotide positions.
messages: Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes.

7227:Dmel CG1239
gene id: 7227:Dmel_CG1239
uniprot id: A0A0B4LGT7
uniprot id: Q9VNH1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Embryonic lethality (PubMed:31145769). Conditional knockdown in ovary leads to female sterility, possibly caused by dysregulation of miRNAs and mRNAsso (PubMed:31145769).
messages: Probable RNA methyltransferase.

7227:Dmel CG10116
gene id: 7227:Dmel_CG10116
uniprot id: Q9VU78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG4924
gene id: 7227:Dmel_CG4924
uniprot id: A1ZAW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1 and WDR77/MEP50; may mediate SNRPD1 and SNRPD3 methylation. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: cytosol

7227:Dmel CG5379
gene id: 7227:Dmel_CG5379
uniprot id: Q4V4S9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG9696
gene id: 7227:Dmel_CG9696
uniprot id: A0A0B4LFX8
uniprot id: Q8MLW2
uniprot id: Q9NDJ2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.
messages: Isoform A and isoform B are present in 0-12 hours embryonic extracts. During embryonic development, isoform A expression is restricted to the developing nervous system, whereas isoform B is ubiquitously expressed. During postembryonic development, isoform B is found in brain, imaginal disks, lymph glands and salivary glands and isoform A is found in some brain regions, photoreceptor cells and sensory organ precursors (at protein level).
messages: Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level).
messages: Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.
messages: Nucleus

7227:Dmel CG32300
gene id: 7227:Dmel_CG32300
uniprot id: Q7KVA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
messages: Divalent metal cations. Calcium or manganese or magnesium.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

7227:Dmel CG33852
gene id: 7227:Dmel_CG33852
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG12369
gene id: 7227:Dmel_CG12369
uniprot id: Q24372
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in embryos.
messages: Expressed on differentiating neuronal cells from the onset of neurogenesis in both the central and peripheral nervous systems. First detected in the cellularized blastoderm, apart from in the ventral side. Expression persists uniformly in the early ectoderm until the end of gastrulation. From stage 10, expressed in an alternating strong/weak pattern in each segment until stage 15 when it disappears. From stage 11, expressed in subsets of neurons and later subsets of glial cells. From early stage 13, strongly expressed in trachea, hindgut, foregut and the nervous system.
messages: Flies exhibit more sinuous tracheal branches and uneven lumen with numerous breaks in the dorsal and lateral branches.
messages: Probable cloning artifact.
messages: Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. Functions as a homophilic cell-adhesion molecule. May play a role in early neuronal differentiation and axon outgrowth.

7227:Dmel CG3022
gene id: 7227:Dmel_CG3022
uniprot id: Q9VPS7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32487
gene id: 7227:Dmel_CG32487
uniprot id: Q9VZW4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG3793
gene id: 7227:Dmel_CG3793
uniprot id: M9NF32
uniprot id: Q9V3K7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

7227:Dmel CG7637
gene id: 7227:Dmel_CG7637
uniprot id: Q9V5P6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP10 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Repressed during starvation.
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

7227:Dmel CG40263
gene id: 7227:Dmel_CG40263
uniprot id: A0A0C4DHN7
uniprot id: Q494G7
uniprot id: Q7PLD0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG15485
gene id: 7227:Dmel_CG15485
uniprot id: Q9VK72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG15220
gene id: 7227:Dmel_CG15220
uniprot id: Q9VYW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

7227:Dmel CG2139
gene id: 7227:Dmel_CG2139
uniprot id: A0A0B4K6V1
uniprot id: A0A0B4KHW3
uniprot id: Q9VA73
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Binds to one calcium ion with high affinity.
messages: Homodimer (via N-terminus).
messages: Membrane
messages: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (By similarity). Necessary for gamma-aminobutyric acid (GABA) uptake in brain mitochondria in response to increased mitochondrial membrane polarization (PubMed:32200800).
messages: Mitochondrion inner membrane
messages: Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain.

7227:Dmel CG33904
gene id: 7227:Dmel_CG33904
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG17440
gene id: 7227:Dmel_CG17440
uniprot id: Q8T3Y1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13922
gene id: 7227:Dmel_CG13922
uniprot id: Q9W086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

7227:Dmel CG34157
gene id: 7227:Dmel_CG34157
uniprot id: A0A0B4KGB9
uniprot id: A0A0B4KGH0
uniprot id: A0A0B4KHE2
uniprot id: A0A0B4KHR4
uniprot id: Q0KI50
uniprot id: Q7YU29
uniprot id: Q9VDW3
uniprot id: Q9VDW6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.
messages: During embryogenesis and in third instar larvae, expression is seen in pericardial cells of the dorsal vessel and in the ventral nerve cord. Expression is absent from both the embryonic and larval musculature.
messages: Expressed both maternally and zygotically throughout development.
messages: Expressed in neuronally derived tissues, mainly the CNS and the brain of stage 16 embryos. Lower level expression is seen in the sensory organs. Expression is absent from the musculature. In larvae, expression is predominant throughout the neuropil and brain and in the eye antennal disks.
messages: Expressed predominantly in all body wall muscle fibers during embryogenesis and in third instar larvae. Expression is also seen in the embryonic and larval ventral midline and larval brain.
messages: Flies exhibit muscle degeneration and lethality. Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes.
messages: Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent, or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes.
messages: Flies that have reduced expression of all isoforms (transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes.
messages: Isoform A is expressed in embryos and larvae and levels increase further in adults. Isoform F has weak expression in embryos, increases in larvae and falls again in adults. Isoform G is weakly expressed in adult flies, and not detectable earlier in development.
messages: Isoform A, isoform F and isoform G are expressed in the midgut endoderm of stage 12 embryos. In stage 16 embryos, expression is also seen in the pericardial cells, cells at the ectoderm segmental border and cells along the midline of the CNS. During embryogenesis, isoform A is also expressed in the visceral mesoderm, muscle attachment sites, mesectodermal cells at the midline, the gut, and throughout muscle fibers. In larvae, isoform A is found in all muscle fibers, but not detectable in the brain or neuropil.
messages: Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: Specifically required for survival and integrity of the larval musculature: the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: Wings exhibit a 'crossveinless' phenotype. Adult flies are viable and the crossvein defect is the sole overt morphological defect observed. Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes.
messages: cytoskeleton
messages: sarcolemma

7227:Dmel CG14167
gene id: 7227:Dmel_CG14167
uniprot id: E7BBS2
uniprot id: Q9VT52
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.
messages: Expressed in the larva, but not in the embryo.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

7227:Dmel CG4824
gene id: 7227:Dmel_CG4824
uniprot id: E2QCR4
uniprot id: Q24009
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Abundantly expressed in ovaries and early embryos.
messages: Belongs to the BicC family.
messages: Expressed in the devoloping ovary. First detectable at stages 3 and 4 of oogenesis but remains very faint until stage 5, when the protein level increases substantially. In stages 4 to 6 is visible throughout the oocyte cytoplasm but is enriched at the osterior pole of the oocyte. During stages 7 to 9 is abundant in the oocyte cytoplasm, with some enrichment at the anterior of the oocyte and around the oocyte cortex. In stage 10 and in later stages is expressed at high levels in the nurse cells (at protein level).
messages: RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression.

7227:Dmel CG2411
gene id: 7227:Dmel_CG2411
uniprot id: P18502
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane
messages: Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).

7227:Dmel CG4362
gene id: 7227:Dmel_CG4362
uniprot id: Q9VDN6
names: Similarity
messages: Belongs to the polysaccharide monooxygenase AA13 family.

7227:Dmel CG10776
gene id: 7227:Dmel_CG10776
uniprot id: M9PE88
uniprot id: Q9VZI9
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Belongs to the scoloptoxin-05 family.

7227:Dmel CG40486
gene id: 7227:Dmel_CG40486
uniprot id: Q5LJT3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG8560
gene id: 7227:Dmel_CG8560
uniprot id: Q961J8
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG42702
gene id: 7227:Dmel_CG42702
uniprot id: A1Z9R4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed throughout life. Expressed in embryos, first- and third-instar larvae, late pupae and adults.
messages: Flies display a structurally abnormal 'filzkoerper' part of the posterior spiracles. They die during larval stage, possibly due to spiracular defects.
messages: In embryos, it is expressed in posterior spiracles and peripheral nervous system.
messages: Nucleus
messages: Probable transcription factor that can both act as an activator or a repressor depending on the context (By similarity). Involved in posterior spiracle development. Acts downstream of ems and cut in posterior spiracle development.

7227:Dmel CG8288
gene id: 7227:Dmel_CG8288
uniprot id: Q9VXQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

7227:Dmel CG12700
gene id: 7227:Dmel_CG12700
uniprot id: Q9VWC5
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG9633
gene id: 7227:Dmel_CG9633
uniprot id: Q24492
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

7227:Dmel CG3069
gene id: 7227:Dmel_CG3069
uniprot id: Q9XZT7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At embryonic stage 9, expression is seen in the mesodermal layer and midgut primordia. The mesoderm-specific expression persists in later stages of development and at its highest level is detected in midgut, hindgut, and differentiating somatic muscle fibers. Coexpressed with Taf10 in the lateral epidermis and anal plate.
messages: Belongs to the TAF10 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). The N-terminus interacts with the histone fold of Taf8.
messages: Cytoplasm
messages: Expressed both maternally and zygotically throughout development.
messages: Nucleus
messages: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

7227:Dmel CG9379
gene id: 7227:Dmel_CG9379
uniprot id: Q9VHC3
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

7227:Dmel CG12500
gene id: 7227:Dmel_CG12500
uniprot id: Q24211
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.
messages: Cytoplasm
messages: Interacts with the second C2 domain of Syt.
messages: Present at synaptic connections both in the CNS and in neuromuscular junctions in the mature embryo (20-22h) and throughout larval development. In the third instar larva, it is expressed in all synaptic bouton types, including I, II and III boutons.
messages: StnB, which is involved in the same pathway, is derived from the same bicistronic transcript that encodes these two different proteins.
messages: Synapse
messages: The Asp-Pro-Phe (DPF) motifs, which are found in many presynatic proteins, are thought to mediate an interaction with AP-2alpha.
messages: synaptic vesicle

7227:Dmel CG15739
gene id: 7227:Dmel_CG15739
uniprot id: Q9VYT0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG10037
gene id: 7227:Dmel_CG10037
uniprot id: A0A0S0WGV5
uniprot id: A0A0S0WNN1
uniprot id: A8E6G8
uniprot id: E1JI48
uniprot id: P16241
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family.
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
messages: Coexpressed with acj6 in overlapping subsets of neurons in the embryonic epidermis and central nervous system. First detected in the precursor of the tracheal pits and the stomodeal invagination and later in the peripheral nervous system.
messages: Expressed at maximal levels in early embryos (6-12 hours). Expressed at lower levels during development.
messages: Nucleus
messages: Was originally thought to interact with acj6.

7227:Dmel CG7499
gene id: 7227:Dmel_CG7499
uniprot id: M9PEN8
uniprot id: Q9V3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

7227:Dmel CG6214
gene id: 7227:Dmel_CG6214
uniprot id: A0A0S0WIA2
uniprot id: Q7KTB7
uniprot id: Q7KTB8
uniprot id: Q7KTB9
uniprot id: Q7KTC0
uniprot id: Q7KTC1
uniprot id: Q7KTC2
uniprot id: Q7KTC3
uniprot id: Q7KTC4
uniprot id: Q7KTC5
uniprot id: Q7KTC6
uniprot id: Q7KTC7
uniprot id: Q7KTC8
uniprot id: Q7KTC9
uniprot id: Q7KTD0
uniprot id: Q9I7N0
uniprot id: Q9VK56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG32042
gene id: 7227:Dmel_CG32042
uniprot id: M9PEM5
uniprot id: Q95T64
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Cell membrane
messages: Expressed from old embryos. Expressed in larvae and adults.
messages: Expressed in uninduced hemocytes and mbn-2 cells.
messages: Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.

7227:Dmel CG1134
gene id: 7227:Dmel_CG1134
uniprot id: Q9VZJ9
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated.
messages: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway.
messages: Interacts with Marf.
messages: Mitochondrion outer membrane
messages: No gross morphological defects. Mitochondria are slightly elongated.

7227:Dmel CG16982
gene id: 7227:Dmel_CG16982
uniprot id: Q9W5E1
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RING-box family.
messages: Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larvae neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). Interacts directly with Cul1 and Slmb (PubMed:11500045). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (Probable).
messages: Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088). During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: Severe pruning defect in ddaC neurons (PubMed:24068890). Also shows defects in ddaD and ddaE neuron pruning and in ddaF apoptosis (PubMed:24068890). RNAi-mediated knockdown results in apical detachment of scolopidial cells in Johnston's organ (PubMed:27331610).
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity).
messages: Widely expressed. Expressed in embryonic, larval and adult tissues.

7227:Dmel CG6220
gene id: 7227:Dmel_CG6220
uniprot id: A1Z9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

7227:Dmel CG17009
gene id: 7227:Dmel_CG17009
uniprot id: Q9VLD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

7227:Dmel CG6729
gene id: 7227:Dmel_CG6729
uniprot id: Q9VKQ6
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity).

7227:Dmel CG9240
gene id: 7227:Dmel_CG9240
uniprot id: D5A7R5
uniprot id: Q9VXR8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

7227:Dmel CG18815
gene id: 7227:Dmel_CG18815
uniprot id: C0PDF4
uniprot id: M9PEW1
uniprot id: Q9I7R0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

7227:Dmel CG30040
gene id: 7227:Dmel_CG30040
uniprot id: Q95NU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG18361
gene id: 7227:Dmel_CG18361
uniprot id: P51140
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DSH family.
messages: Cytoplasm
messages: Expressed at high levels at 0-1 hour and from 5-17 hours. Also expressed at high levels in early pupae.
messages: Found in egg chambers of the ovary and ubiquitously throughout embryogenesis and in disks. Expression is not seen in salivary glands, muscles or ventral ganglia but is observed in brain lobes.
messages: Interacts with nkd. This interaction may require zinc.
messages: Membrane
messages: Nucleus
messages: Phosphorylated. Wg signaling generates the hyperphosphorylated active forms.
messages: Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.

7227:Dmel CG3086
gene id: 7227:Dmel_CG3086
uniprot id: A4V402
uniprot id: P49071
names: Function
names: PTM
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25).
messages: Phosphorylated and activated by MAP kinase.

7227:Dmel CG13897
gene id: 7227:Dmel_CG13897
uniprot id: M9PBH2
uniprot id: Q9W0N1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG33957
gene id: 7227:Dmel_CG33957
uniprot id: M9ND93
uniprot id: M9NFV3
uniprot id: M9PCJ5
uniprot id: M9PCK2
uniprot id: M9PFA3
uniprot id: M9PFA8
uniprot id: M9PFJ2
uniprot id: M9PFP0
uniprot id: M9PFP4
uniprot id: M9PI63
uniprot id: Q400N1
uniprot id: Q400N2
names: Subcellular Location Annotation
messages: centrosome

7227:Dmel CG14031
gene id: 7227:Dmel_CG14031
uniprot id: Q9VMS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG15406
gene id: 7227:Dmel_CG15406
uniprot id: Q9VQN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG10898
gene id: 7227:Dmel_CG10898
uniprot id: Q9VGM4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7227:Dmel CG5131
gene id: 7227:Dmel_CG5131
uniprot id: Q9VJD0
names: Similarity
messages: Belongs to the peptidase M76 family.

7227:Dmel CG10564
gene id: 7227:Dmel_CG10564
uniprot id: M9PD54
uniprot id: M9PG27
uniprot id: M9PID8
uniprot id: Q9VP76
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalytically inactive.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling (PubMed:10603085, PubMed:23929551). Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine (PubMed:19046378). Has no role in bitter perception (PubMed:19046378). In the circadian brain neuron evening cells (E-cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases (PubMed:23929551).
messages: Cell membrane
messages: Does not have adenylyl cyclase activity and it is not involved in taste perception.
messages: Expressed in labella, particularly in sugar-sensitive gustatory receptor neurons (GRNs).
messages: Isoform B: Ubiquitously expressed in embryos, larvae and adult (PubMed:10603085). Isoform C: Temporally restricted to the earliest hours of embryogenesis before cellularization (PubMed:10603085). As germ band extension commences, expression decreases along the entire ventral surface of the embryo and is restricted to the cephalic furrow (CF) and anterior and posterior dorsal transverse folds (DTFs) (PubMed:10603085). By state 7, restricted expression in the CF and DTFs on the dorsal and lateral surfaces of the embryo (PubMed:10603085).
messages: Membrane
messages: RNAi-mediated knockdown in sugar gustatory neurons results in reduced sucrose response and no alteration in response to water (PubMed:19046378). RNAi-mediated knockdown in the pacemaker dorsal lateral neurons (LNDs) results in reduced Pigment-dispersing factor (Pdf) response in the circadian brain neurons evening cells (E-cells) (PubMed:23929551). Isoform B: Results in reduced sucrose and trehalose substances response and no alteration of water response or bitter perception (PubMed:19046378).
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

7227:Dmel CG4300
gene id: 7227:Dmel_CG4300
uniprot id: Q9VTW0
uniprot id: Q9VTW1
uniprot id: X2JB05
uniprot id: X2JGL7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

7227:Dmel CG3309
gene id: 7227:Dmel_CG3309
uniprot id: Q9W4D1
uniprot id: X2JCL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

7227:Dmel CG32031
gene id: 7227:Dmel_CG32031
uniprot id: A8JNP1
uniprot id: A8JNP2
uniprot id: P48610
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

7227:Dmel CG9828
gene id: 7227:Dmel_CG9828
uniprot id: M9PD23
uniprot id: Q9VK35
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG16717
gene id: 7227:Dmel_CG16717
uniprot id: Q9VT29
names: Similarity
messages: Belongs to the UPF0046 family.

7227:Dmel CG2669
gene id: 7227:Dmel_CG2669
uniprot id: A0A126GUQ3
uniprot id: Q9VNA8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DONSON family.
messages: Essential for DNA amplification in the ovary and required for cell proliferation during development.
messages: Expressed throughout development.
messages: Expression peaks during late G1 and S phase (at protein level).
messages: Flies display a distinct thin-eggshell phenotype.
messages: Nucleus

7227:Dmel CG11242
gene id: 7227:Dmel_CG11242
uniprot id: A1ZBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

7227:Dmel CG11964
gene id: 7227:Dmel_CG11964
uniprot id: Q9VHJ7
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8219
gene id: 7227:Dmel_CG8219
uniprot id: Q9VRV9
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG13624
gene id: 7227:Dmel_CG13624
uniprot id: Q9VC61
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. CREBRF subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Interacts (via C-terminus) with REPTOR-BP (via C-terminus). Interacts with the TORC1 complex component raptor. Interacts (when phosphorylated) with 14-3-3zeta, this interaction may assist its cytoplasmic retention.
messages: Nucleus
messages: Phosphorylation by the TORC1 kinase complex at Ser-527 and Ser-530 abolishes nuclear localization. Upon TORC1 inhibition, dephosphorylated in a mts/PP2a-dependent manner leading to nuclear localization.
messages: Sensitive to nutrient stress. Larvae display no obvious phenotype under normal feeding conditions; larval growth and development is normal, and there is no effect on triglyceride and glycogen levels. However when mutants pupate and become adults they display reduced triglyceride and glycogen stores leading to adults dying within 18 hours of starvation whereas controls survive 2.5 days without food. Larvae are also sensitive to nutrient stress displaying 50% lethality when fed a low nutrient diet. Double knockouts of REPTOR with a hypomorphic Tor, rescue the Tor-mediated increase in triglyceride levels and partially rescue the larval growth defect.
messages: Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts as the transcriptional activator. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking site for 14-3-3 proteins. Upon TORC1 inhibition resulting from nutrient stress, REPTOR is recruited into the nucleus where it interacts with REPTOR-BP and together they maintain organismal metabolism by activating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis. The complex also appears to negatively regulate some aspects of TORC1-dependent larval growth.

7227:Dmel CG2033
gene id: 7227:Dmel_CG2033
uniprot id: E1JJM9
uniprot id: P48149
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

7227:Dmel CG1894
gene id: 7227:Dmel_CG1894
uniprot id: Q9VAV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7227:Dmel CG4302
gene id: 7227:Dmel_CG4302
uniprot id: Q9W2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG7441
gene id: 7227:Dmel_CG7441
uniprot id: Q9VVL8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG6680
gene id: 7227:Dmel_CG6680
uniprot id: Q0E8C8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: In larvae, highly expressed in the tracheal system. Weak expression is also detected in other larval tissues including the gut and epidermis.
messages: RNAi-mediated knockdown results in spontaneous melanization of the tracheal system in larvae and pupae (PubMed:18854145, PubMed:22227521). Displays melanization at the 2nd or 3rd larval stage and affected larvae die a few days after it first occurs (PubMed:18854145). Melanization is first detected between tracheal cells and the overlying cuticle, then increases in intensity and spreads to the epithelial layer of the affected tracheal cells (PubMed:18854145). Increased expression of the antimicrobial gene Drs in the trachea and fat body (PubMed:18854145).
messages: Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection (PubMed:18854145, PubMed:22227521). Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade (PubMed:18854145).
messages: extracellular space

7227:Dmel CG6145
gene id: 7227:Dmel_CG6145
uniprot id: A1Z9F0
uniprot id: E1JH60
uniprot id: E1JH61
uniprot id: Q6IDH2
uniprot id: Q8SZX5
names: Similarity
messages: Belongs to the NAD kinase family.

7227:Dmel CG1341
gene id: 7227:Dmel_CG1341
uniprot id: Q7KMQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

7227:Dmel CG13391
gene id: 7227:Dmel_CG13391
uniprot id: Q9VLM8
uniprot id: T2FFB7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Monomer.

7227:Dmel CG18681
gene id: 7227:Dmel_CG18681
uniprot id: P35005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG2330
gene id: 7227:Dmel_CG2330
uniprot id: Q9VI25
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the neurochondrin family.
messages: Expressed in both somatic and visceral musculature.
messages: Strongly up-regulated in Mhc mutants suggesting a role in muscle function.

7227:Dmel CG10342
gene id: 7227:Dmel_CG10342
uniprot id: Q9VET0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NPY family.
messages: Expressed in midgut, brain lobes and ventral nerve cord of larvae. Predominantly expressed in two pairs of protocerebral neurons in the larval CNS (at protein level). Intense expression is also seen in the fan-shaped body of the central complex and two lateral areas of the lower part of the central brain that appear to harbor the giant commissural interneurons of the giant fiber pathway (at protein level). Upon glucose feeding, two additional dNPFergic neurons are consistently detected on the ventromedial surface of the subesophageal ganglion (SEG) of third instars larvae. Expressed in a subset of sugar-responsive PAIN neurons in the thoracic body but is absent from other peripheral PAIN neurons.
messages: Expression is high in larvae seeking food and is down-regulated in late embryos coinciding with the onset of the behavior of older larvae, including food aversion, hypermobility, and cooperative burrowing. In males, expression is increased by mating and reduced by sexual deprivation.
messages: Increased NPF or NPFR activity dominantly suppresses PAIN-mediated food aversion in postfeeding larvae. Deficiency in NPF/NPFR signaling causes decreased alcohol sensitivity and overexpression causes a hypersensitive response to alcohol sedation. Controlled functional disruption of NPF or NPFR neurons rapidly triggers acute resistance to ethanol sedation.
messages: Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference.
messages: Secreted

7227:Dmel CG2656
gene id: 7227:Dmel_CG2656
uniprot id: Q9VI70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

7227:Dmel CG2051
gene id: 7227:Dmel_CG2051
uniprot id: Q0KIB3
names: Similarity
messages: Belongs to the HAT1 family.

7227:Dmel CG17725
gene id: 7227:Dmel_CG17725
uniprot id: P20007
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Monomer.

7227:Dmel CG4381
gene id: 7227:Dmel_CG4381
uniprot id: Q9VG97
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Has no glutathione S-transferase activity.
messages: Homodimer.
messages: In vitro shows no activity towards glutathione. Lacks 16 amino acids at the N-terminus including a glutathione binding site known to be important for catalysis.

7227:Dmel CG12252
gene id: 7227:Dmel_CG12252
uniprot id: Q9W147
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

7227:Dmel CG4865
gene id: 7227:Dmel_CG4865
uniprot id: Q9W4M8
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918).
messages: Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:18443220, PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules (PubMed:18443220).
messages: The name 'dim gamma-tubulin 4' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt4 in S2 cells.
messages: spindle

7227:Dmel CG1163
gene id: 7227:Dmel_CG1163
uniprot id: A0A1B2AK96
uniprot id: Q24320
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
messages: Nucleus

7227:Dmel CG7378
gene id: 7227:Dmel_CG7378
uniprot id: A8JUQ2
uniprot id: Q9VWN2
uniprot id: X2JEB8
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7227:Dmel CG4908
gene id: 7227:Dmel_CG4908
uniprot id: Q9VL22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG12223
gene id: 7227:Dmel_CG12223
uniprot id: B7Z0Z0
uniprot id: F2FBA6
uniprot id: Q24537
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Binds preferentially single-stranded DNA and unwinds double-stranded DNA.
messages: Chromosome
messages: Nucleus

7227:Dmel CG30445
gene id: 7227:Dmel_CG30445
uniprot id: A1Z6N2
names: Similarity
messages: Belongs to the group II decarboxylase family.

7227:Dmel CG1427
gene id: 7227:Dmel_CG1427
uniprot id: A0A0C4DHG1
uniprot id: Q9VNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

7227:Dmel CG1464
gene id: 7227:Dmel_CG1464
uniprot id: O18381
uniprot id: Q53XF9
uniprot id: Q59DQ1
uniprot id: Q59DQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expression is confined to the eye imaginal disks, parts of the brain, the ventral ganglion and the salivary glands.
messages: Involved in eye morphogenesis.
messages: Nucleus

7227:Dmel CG8392
gene id: 7227:Dmel_CG8392
uniprot id: A0AQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG14283
gene id: 7227:Dmel_CG14283
uniprot id: Q9VE04
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the mitochondrion-specific ribosomal protein mL55 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Expressed both maternally and zygotically. Expressed throughout embryogenesis.
messages: Flies do not grow after hatching, moved slowly and died as first instar larvae.
messages: Involved in mitochondrial biogenesis and G2/M phase cell cycle progression.
messages: Mitochondrion
messages: Ubiquitously expressed (at protein level).

7227:Dmel CG14996
gene id: 7227:Dmel_CG14996
uniprot id: M9PE30
uniprot id: Q9VZI1
names: Similarity
messages: Belongs to the calponin family.

7227:Dmel CG42631
gene id: 7227:Dmel_CG42631
uniprot id: Q9VTM5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Encoded on a bicistronic transcript that code for two proteins mtTFB1 and CG42630.
messages: Mitochondrion
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. In contrast to mtTFB2, it does not have a critical role in either transcription or regulation of the copy number of mitochondrial DNA.

7227:Dmel CG6485
gene id: 7227:Dmel_CG6485
uniprot id: Q9VVF0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

7227:Dmel CG5315
gene id: 7227:Dmel_CG5315
uniprot id: A4V392
uniprot id: C6TP81
uniprot id: Q9VCY8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.
messages: Belongs to the ADIPOR family.
messages: Cell membrane
messages: Expressed throughout development and in adult.
messages: In larval and adult brain, expressed in insulin-producing cells and in neurons of the subesophageal region. Also expressed in lateral neurons of the adult brain (at protein level). In third instar larvae, expressed in central nervous system (CNS), imaginal disk, salivary gland, fat body, gut and malphigian tubules.
messages: Membrane

7227:Dmel CG33862
gene id: 7227:Dmel_CG33862
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG33497
gene id: 7227:Dmel_CG33497
uniprot id: Q7KWG3
uniprot id: X2JCQ7
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7227:Dmel CG4901
gene id: 7227:Dmel_CG4901
uniprot id: Q9VL25
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Mutants show hypotrophy of the nucleolus.
messages: Part of a translational control module, also containing pths/DDX47 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation.
messages: nucleolus

7227:Dmel CG15744
gene id: 7227:Dmel_CG15744
uniprot id: Q7KV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG11652
gene id: 7227:Dmel_CG11652
uniprot id: Q9VTM2
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

7227:Dmel CG33976
gene id: 7227:Dmel_CG33976
uniprot id: A0A126GUT9
uniprot id: E1JIJ4
uniprot id: Q4LBB9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037).
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in adult, pupae and third instar larvae. Levels peak at the late embryonic and late larvae stages. Relatively low expression in the pupal stage, with a slight increase in the adult.
messages: In the adult, expressed in the superior protocerebrum and the optic lobe medulla of the central nervous system, nurse cells of egg chambers in the ovary at oogenic stages 1-10, and spermatogonia and spermatocytes in the testis (PubMed:22303848). Expressed in the oviduct epithelium (PubMed:25099506). Also expressed in the spermatheca (PubMed:25353988). Expressed in embryonic and larval ventral nerve cord and brain lobe, embryonic and larval salivary glands and larval imaginal disk and midgut (PubMed:22303848). Also expressed in larval synaptic boutons (PubMed:21186359).
messages: Males appear viable and fertile whereas females are sterile (PubMed:25099506, PubMed:25353988). Female pre- and post-mating behaviors, such as courtship and post-mating rejection, are not affected and sperm storage appears normal (PubMed:25099506, PubMed:25353988). However, ovulation and egg-laying is severely impaired and females display a strong delay in copulation rates (PubMed:25099506, PubMed:25353988). Ovaries are enlarged due to a higher number of retained eggs and the small number of eggs that are laid are not fertilized (PubMed:25353988). Larvae fail to respond to starvation by increasing locomotor activity (PubMed:21186359). Reduced growth of octopaminergic and glutamatergic (type I and type II) neuromuscular junctions (PubMed:21186359). Decrease in the number of terminal type I and type II boutons and in the motile filopodia-like extensions (synaptopods) which form during the expansion of type II terminals in developing larvae (PubMed:21186359).

7227:Dmel CG17885
gene id: 7227:Dmel_CG17885
uniprot id: Q9W5G6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanal, heptanal, and 2-heptanone.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG5682
gene id: 7227:Dmel_CG5682
uniprot id: M9PCV1
uniprot id: Q9VK27
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7227:Dmel CG16721
gene id: 7227:Dmel_CG16721
uniprot id: Q9W461
names: Similarity
messages: Belongs to the TCP11 family.

7227:Dmel CG12859
gene id: 7227:Dmel_CG12859
uniprot id: Q6IDF5
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.

7227:Dmel CG6884
gene id: 7227:Dmel_CG6884
uniprot id: Q9VVS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which may include CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Nucleus

7227:Dmel CG9437
gene id: 7227:Dmel_CG9437
uniprot id: Q9W2K3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG16736
gene id: 7227:Dmel_CG16736
uniprot id: Q9VHG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG9726
gene id: 7227:Dmel_CG9726
uniprot id: Q9VA65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG11546
gene id: 7227:Dmel_CG11546
uniprot id: Q7JX82
names: Similarity
messages: Belongs to the GIPC family.

7227:Dmel CG5492
gene id: 7227:Dmel_CG5492
uniprot id: Q7JZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG5047
gene id: 7227:Dmel_CG5047
uniprot id: Q9VPD5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mTERF family.
messages: Binds promoter DNA and regulates initiation of transcription (By similarity). Regulator of mitochondrial ribosome biogenesis and translation that is essential for development (PubMed:16787637, PubMed:23300484). Required for normal mitochondrial transcription and translation (PubMed:16787637, PubMed:23300484). Required for assembly of mitochondrial respiratory complexes and normal mitochondrial function (PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:23300484).
messages: Mitochondrion
messages: RNAi-mediated knockdown is pupal lethal. Larvae display a delay in development and a decrease in body size. Display progressive defects in mitochondrial respiratory chain capacity as well as a decrease in the enzyme activity of all mitochondrial oxidative phosphorylation complexes. Decrease in enzyme activity is particularly severe in complex I and IV which also display a decrease in the levels of their assembled complexes. Progressive reduction in 16S rRNA levels and impaired assembly of the large (39S) mitochondrial ribosomal subunit. Increase in mitochondrial DNA (mtDNA) transcription and impaired mitochondrial translation.

7227:Dmel CG5207
gene id: 7227:Dmel_CG5207
uniprot id: Q9VGQ3
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG3131
gene id: 7227:Dmel_CG3131
uniprot id: M9PCF1
uniprot id: Q9VQH2
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane
messages: Peroxidase activity is inhibited by aminotriazole and azide.
messages: Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794). Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120).
messages: RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora.

7227:Dmel CG6567
gene id: 7227:Dmel_CG6567
uniprot id: Q9VGV9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

7227:Dmel CG14133
gene id: 7227:Dmel_CG14133
uniprot id: Q9VTM0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S6 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted, Pldn and Snapin. Interacts with Blos1, Blos4 and Dysb.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021). In response to high synaptic activity at neuromuscular junctions, plays a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021).
messages: Expressed throughout development from embryo to adult stages (at protein level) (PubMed:28317021). In larvae, expressed at the neuromuscular junction both pre- and postsynaptically (at protein level) (PubMed:28317021).
messages: Synapse
messages: Viable and fertile (PubMed:28317021). In the neuromuscular junctions, results in abnormal tubular endosomal compartments and a reduction in early endosomes which leads to a decrease recycling and recovery of the synaptic vesicle pool and results in failure to sustain neurotransmitter release during high-frequency stimulation (PubMed:28317021). Does not affect synaptic morphology or basal function (PubMed:28317021).
messages: Z line
messages: cytoskeleton

7227:Dmel CG33856
gene id: 7227:Dmel_CG33856
uniprot id: Q4AB57
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG13591
gene id: 7227:Dmel_CG13591
uniprot id: Q24536
names: Similarity
messages: Belongs to the casein kinase 2 subunit beta family.

7227:Dmel CG4552
gene id: 7227:Dmel_CG4552
uniprot id: Q9VPW9
names: Subcellular Location Annotation
messages: trans-Golgi network

7227:Dmel CG15860
gene id: 7227:Dmel_CG15860
uniprot id: Q9W0Y6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family.
messages: Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons.
messages: Membrane
messages: Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.
messages: Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.

7227:Dmel CG6513
gene id: 7227:Dmel_CG6513
uniprot id: Q9VUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

7227:Dmel CG8435
gene id: 7227:Dmel_CG8435
uniprot id: Q7JVH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.

7227:Dmel CG45784
gene id: 7227:Dmel_CG45784
uniprot id: A0A0A1EI90
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7227:Dmel CG7073
gene id: 7227:Dmel_CG7073
uniprot id: Q9VD29
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

7227:Dmel CG5860
gene id: 7227:Dmel_CG5860
uniprot id: Q9VEK4
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG6331
gene id: 7227:Dmel_CG6331
uniprot id: Q9VCA2
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Chimeric cDNA.
messages: Expressed in embryos and adults at low level. Expressed at higher level in third instar larvae.
messages: Membrane
messages: Probably transports organic cations.

7227:Dmel CG4145
gene id: 7227:Dmel_CG4145
uniprot id: P08120
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: Belongs to the type IV collagen family.
messages: Collagen type IV is specific for basement membranes.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

7227:Dmel CG10444
gene id: 7227:Dmel_CG10444
uniprot id: Q8SWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG4760
gene id: 7227:Dmel_CG4760
uniprot id: Q24207
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM DAZ family.
messages: Cytoplasm
messages: Interacts with the translational regulator orb2.
messages: Not expressed in embryos. Expressed in larvae, pupae and adult males. Expressed during spermatogenesis.
messages: Nucleus
messages: RNA-binding protein that plays a central role in spermatogenesis. Required for meiotic entry and germline differentiation, at the transition between G2 and M phases of meiosis I. Acts by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. Essential for translation of twine (twe) mRNA. Required for the expression of various genes such as CG6784, CG17210, CG15841 scpr-B, scpr-C, and rho-6.
messages: Testis specific.

7227:Dmel CG17510
gene id: 7227:Dmel_CG17510
uniprot id: B7YZT2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:18443288, PubMed:20194754). Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission (PubMed:18443288).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown results in elongated mitochondria.
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

7227:Dmel CG33156
gene id: 7227:Dmel_CG33156
uniprot id: A1Z9F4
uniprot id: A8DYC9
uniprot id: Q7JRK7
uniprot id: Q86NK6
uniprot id: Q8IGA7
names: Similarity
messages: Belongs to the NAD kinase family.

7227:Dmel CG9466
gene id: 7227:Dmel_CG9466
uniprot id: Q9VLI0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG33113
gene id: 7227:Dmel_CG33113
uniprot id: E1JHT6
uniprot id: E1JHT9
uniprot id: Q7KTP4
uniprot id: Q9VMV9
uniprot id: Q9VMW1
uniprot id: Q9VMW2
uniprot id: Q9VMW4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG3491
gene id: 7227:Dmel_CG3491
uniprot id: Q9V453
names: Similarity
messages: Belongs to the SBNO family.

7227:Dmel CG7921
gene id: 7227:Dmel_CG7921
uniprot id: A0A0B4KHE4
uniprot id: Q59DT4
uniprot id: Q961U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG32226
gene id: 7227:Dmel_CG32226
uniprot id: Q9VWB0
names: Function
names: Similarity
messages: Belongs to the TECPR1 family.
messages: Involved in peroxisome biogenesis.

7227:Dmel CG5338
gene id: 7227:Dmel_CG5338
uniprot id: A0A0B4KGR4
uniprot id: Q7KS38
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

7227:Dmel CG9664
gene id: 7227:Dmel_CG9664
uniprot id: M9NEQ1
uniprot id: Q0E8U2
uniprot id: Q8IQ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG11678
gene id: 7227:Dmel_CG11678
uniprot id: P45890
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP6 subfamily.
messages: Expressed both maternally and zygotically. Expressed throughout development, with highest expression observed in embryos (at protein level).
messages: cytoskeleton
messages: nucleoplasm

7227:Dmel CG7937
gene id: 7227:Dmel_CG7937
uniprot id: Q7KS72
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG42863
gene id: 7227:Dmel_CG42863
uniprot id: Q9W060
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that regulates intracellular membrane fusion reactions (By similarity) (PubMed:33725482). Regulates the fusion of lysosome-related organelles (PubMed:33725482). Promotes microtubules nucleation and centrosomal recruitment of microtubule nucleating proteins such as msps (PubMed:33725482). In syncytial embryos, during the formation of yolk granules, suppresses vesicle fusion events with lipid droplets, possibly via interaction with Rab5 (PubMed:33725482). In the eye, regulates pigment granules size (PubMed:22934826). In hemocytes, required for the late steps of bacteria phagocytosis (PubMed:22934826). In fat body, required for autophagosome maturation (PubMed:22934826).
messages: Expressed in follicular epithelial cells on the side facing the developing oocyte where yolk components are secreted before uptake into the oocyte (at protein level) (PubMed:33725482). Expressed in syncytial embryos (at protein level) (PubMed:33725482).
messages: Interacts with Rab5; the interaction is independent of GDP or GTP (PubMed:33725482). Interacts with msps (PubMed:33725482).
messages: Vesicle
messages: spindle
messages: spindle pole

7227:Dmel CG18593
gene id: 7227:Dmel_CG18593
uniprot id: Q8MR62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosducin family.
messages: Cytoplasm
messages: Modulates the activation of caspases during apoptosis.

7227:Dmel CG43689
gene id: 7227:Dmel_CG43689
uniprot id: M9PGE8
uniprot id: M9PGM4
uniprot id: M9PH00
uniprot id: M9PJ12
uniprot id: Q9W4N4
uniprot id: X2JCH4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4122
gene id: 7227:Dmel_CG4122
uniprot id: P42787
uniprot id: Q6AWJ5
uniprot id: X2J9Z1
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Embryonic and adult stages (PubMed:8000074, PubMed:16556608, PubMed:16676361). Also detected in larvae (PubMed:16556608).
messages: Expressed in the central nervous system (CNS) of adults and larvae (PubMed:31309630). In the adult brain, increased levels of expression in the mushroom body (MB) and neurosecretory cells (PubMed:27430952).
messages: Inhibited by 2-guanidinoethylmercaptosuccinic acid (GEMSA).
messages: Intron retention.
messages: Larvae lethal (PubMed:16556608, PubMed:20386952). Larvae die around the first molt at the first or second instar stage (PubMed:16556608).
messages: Membrane
messages: Metallocarboxypeptidase that catalyzes the release of C-terminal arginine or lysine residues from peptides and proteins (PubMed:16556608, PubMed:31309630, PubMed:20600119, PubMed:12393882, PubMed:20386952). Functionally important for processing a broad range of proteins including growth factors, peptide hormones (such as Akh) and neuropeptides (PubMed:16556608, PubMed:27430952, PubMed:31309630, PubMed:20600119, PubMed:20386952). Consequently, it is involved in a wide range of processes including viability, memory formation, locomotive activity, wing formation, and peptide-regulated behaviors such as starvation-induced hyperactivity, appetitive gustatory preference, and cold and ethanol sensitivity (PubMed:27430952, PubMed:31309630, PubMed:20600119, PubMed:20386952). Key enzyme in neuropeptide processing (PubMed:31309630). Involved in regulation of memory formation, possibly via the insulin pathway in neurosecretory cells (PubMed:27430952).
messages: Monomer.
messages: Named 'silver' because mutants form cuticular structures that are pale and silvery in color due to reduced melanization.
messages: Secreted
messages: The C-terminus in isoforms 4, 5 and 6 may be required for the retrograde transport of these proteins from the cell membrane to the trans-Golgi network.
messages: There are 3 carboxypeptidase-like domains (PubMed:12393882, PubMed:20386952). Only the first two domains seem to have catalytic activity (PubMed:12393882, PubMed:16556608, PubMed:20386952). However, in svr proteins there are two alternative carboxypeptidase-like 1 domains (CP-1), a catalytically inactive 1A form (in isoforms 3, 4 and 6) and an active 1B form (in isoforms 1, 5, and 7) (PubMed:12393882). All 3 carboxypeptidase-like domains (active CP-1, CP-2 and CP-3) appear to necessary for maintaining full viability (PubMed:20386952). The active CP-1 and CP-2 domains display redundant functions in terms of processing peptides involved in viability, and in behaviors like cold and ethanol sensitivity, as well as long-term memory (PubMed:20386952). However, the active CP-1 domain appears to preferentially remove C-terminal Arg residues while CP-2 preferentially removes C-terminal Lys residues (PubMed:20386952). The active CP-1 is sufficient for survival (PubMed:16556608). The CP-3 domain appears to be important for development from embryo to adult (PubMed:20386952).
messages: perinuclear region
messages: trans-Golgi network

7227:Dmel CG42299
gene id: 7227:Dmel_CG42299
uniprot id: Q9VXT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

7227:Dmel CG10391
gene id: 7227:Dmel_CG10391
uniprot id: Q9VJ71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG31813
gene id: 7227:Dmel_CG31813
uniprot id: Q8IP68
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adults display disrupted sleep. Consolidation of daytime sleep is decreased, particularly in males, such that the number of bouts is increased and bout duration is decreased. Adults are more easily roused from sleep and have impaired sleep rebound, thereby recovering sleep more slowly after sleep deprivation. Mutants infected with S.marcescens or E.coli at zeitgeber time 18 (ZT18) show a significant reduction in infection-induced sleep during ZT0 to ZT2 the next morning.
messages: Antimicrobial protein which is essential for the homeostatic regulation of sleep. Promotes sleep following sleep deprivation or bacterial infection and increases survival following bacterial infection. Likely to promote survival to bacterial infection in two ways; by contributing to the innate immune response and by promoting sleep during sickness to aid recovery.
messages: Detected in the brain where it accumulates in the dorsal fan-shaped body following sleep deprivation (at protein level). Expressed in the adult body.
messages: In the adult brain by sleep deprivation (at protein level). Up-regulated after bacterial infection in the whole adult body and in brains of some flies.
messages: Secreted
messages: The name 'nemuri' means sleep in Japanese.

7227:Dmel CG10864
gene id: 7227:Dmel_CG10864
uniprot id: Q9VE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG32232
gene id: 7227:Dmel_CG32232
uniprot id: Q8IRA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

7227:Dmel CG13229
gene id: 7227:Dmel_CG13229
uniprot id: Q7JVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG3533
gene id: 7227:Dmel_CG3533
uniprot id: P10379
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Required for normal axon patterning during neurogenesis.

7227:Dmel CG7840
gene id: 7227:Dmel_CG7840
uniprot id: Q9VLP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

7227:Dmel CG4020
gene id: 7227:Dmel_CG4020
uniprot id: Q9W459
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG6755
gene id: 7227:Dmel_CG6755
uniprot id: H5V896
uniprot id: Q9VCP0
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Expression at low levels during embryonic expression and peaks during mid larval stages.
messages: Nucleus
messages: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). May play an important role in metamorphosis.
messages: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

7227:Dmel CG12173
gene id: 7227:Dmel_CG12173
uniprot id: Q9VN95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

7227:Dmel CG4379
gene id: 7227:Dmel_CG4379
uniprot id: P12370
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Composed of two regulatory chains and two catalytic chains.
messages: More abundant in adult head than adult body.
messages: Serine/threonine-protein kinase involved in memory formation (PubMed:29473541). Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity (PubMed:29473541). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane (PubMed:29444420).

7227:Dmel CG14887
gene id: 7227:Dmel_CG14887
uniprot id: G4LU61
uniprot id: P17719
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dihydrofolate reductase family.
messages: By interacting with vestigial (vg), may control genes involved in DNA replication.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
messages: Monomer. Interacts with vg.

7227:Dmel CG9635
gene id: 7227:Dmel_CG9635
uniprot id: A0A0B4K7T7
uniprot id: A0A0B4LFF8
uniprot id: A1ZAN6
uniprot id: A1ZAN7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

7227:Dmel CG15094
gene id: 7227:Dmel_CG15094
uniprot id: A1ZBD9
uniprot id: A1ZBE0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8418
gene id: 7227:Dmel_CG8418
uniprot id: Q7JMZ0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1367
gene id: 7227:Dmel_CG1367
uniprot id: C0HKQ7
uniprot id: C0HKQ8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cecropin family.
messages: By bacterial infection (at protein level) (PubMed:16510152). Induced as part of the humoral response to a bacterial invasion (PubMed:2390977). Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours (PubMed:2104802). Similar response is seen when flies ingest bacteria present in their food (PubMed:2104802). 8 hours after bacterial infection of embryos (2-6 hours after hatching), up-regulated in the larval epidermis and 16 h post-infection is up-regulated in the larval fat body (PubMed:11266367). Up-regulated in the larval fat body by injection of bacterial lipopolysaccharides (LPS), but not up-regulated in the epidermis (PubMed:11266367).
messages: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria (PubMed:2390977, PubMed:11266367). Functions in the imd/NF-kappa-B (Imd) epithelial and humoral immune response to Gram-negative bacteria (PubMed:11266367).
messages: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
messages: Hemolymph (at protein level) (PubMed:16510152). Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria (PubMed:2390977). Maximal expression in the adult involves fat body cells of the head, thorax and abdomen (PubMed:2390977).
messages: Induced as part of the humoral response to a bacterial invasion (PubMed:2390977). Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours (PubMed:2104802). Similar response is seen when flies ingest bacteria present in their food (PubMed:2104802).
messages: Secreted
messages: Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen.

7227:Dmel CG3510
gene id: 7227:Dmel_CG3510
uniprot id: C9QPI9
uniprot id: P20439
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
messages: Interacts with the protein kinase Cdk1 to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

7227:Dmel CG30502
gene id: 7227:Dmel_CG30502
uniprot id: Q8SXY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG32201
gene id: 7227:Dmel_CG32201
uniprot id: Q8IQS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG1838
gene id: 7227:Dmel_CG1838
uniprot id: Q9V4F4
names: Similarity
messages: Belongs to the TGF-beta family.

7227:Dmel CG14413
gene id: 7227:Dmel_CG14413
uniprot id: Q9VY28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7227:Dmel CG11130
gene id: 7227:Dmel_CG11130
uniprot id: P56175
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).
messages: nucleolus

7227:Dmel CG17935
gene id: 7227:Dmel_CG17935
uniprot id: Q01645
names: Developmental Stage
names: Domain
names: Similarity
names: Tissue Specificity
messages: Belongs to the MST(3)CGP family.
messages: Primary spermatocytes.
messages: Testis.
messages: This protein is mostly composed of repetitive C-G-P motifs.

7227:Dmel CG9495
gene id: 7227:Dmel_CG9495
uniprot id: A0A0B4K6M7
uniprot id: Q9VHA0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCM family.
messages: Expressed both maternally and zygotically. Levels are highest in 0-2 hours embryos and at lower levels during later embryonic and larval stages. A modest increase in expression is seen during the pupal stage. Expressed throughout the 9 hours embryo. After 12 hours expression is concentrated in the central nervous system.
messages: Nucleus
messages: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.
messages: Scm associates with the PRC1 core complex containing PSC, PC, PH and Sce/RING1. Forms homotypic and heterotypic interactions. Interacts with the SAM domain of ph-p via its SAM domain in vitro. Interacts with corto in vitro.
messages: The SAM domain is essential for function.

7227:Dmel CG10593
gene id: 7227:Dmel_CG10593
uniprot id: M9PCE8
uniprot id: Q9VLJ6
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Defective heart morphogenesis leading to lethality.
messages: Expressed in presumptive heart cells during dorsal closure.
messages: Glycosylated.
messages: In contrast to ance, does not hydrolyze angiotensin I.
messages: Inhibited by captopril, lisinopril, trandolaprilat, fosinoprilat and enalaprilat.
messages: May be involved in the specific maturation or degradation of a number of bioactive peptides. May have a role in the specification of heart progenitors.
messages: extracellular space

7227:Dmel CG2813
gene id: 7227:Dmel_CG2813
uniprot id: Q9VPR7
names: Similarity
messages: Belongs to the scoloptoxin-05 family.

7227:Dmel CG9786
gene id: 7227:Dmel_CG9786
uniprot id: P05084
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hunchback C2H2-type zinc-finger protein family.
messages: Expressed maternally and zygotically. Expression of the maternal transcript decreases until embryonic stage 14, zygotic transcript is first detected at stage 11.
messages: Gap class segmentation protein that controls development of head structures.
messages: In embryo, expression of maternal transcript is highest in anterior region. Zygotic transcript is expressed in anterior region until the beginning of gastrulation and in posterior region until early gastrulation. After this, it is expressed in developing nervous system.
messages: Nucleus

7227:Dmel CG6459
gene id: 7227:Dmel_CG6459
uniprot id: Q7JXC4
names: Similarity
messages: Belongs to the MAM33 family.

7227:Dmel CG9383
gene id: 7227:Dmel_CG9383
uniprot id: C0MIY4
uniprot id: Q9V464
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Chromosome
messages: Component of the replication coupling assembly factor (RCAF), composed of asf1, histone H3 and histone H4 (PubMed:10591219). Interacts with the Caf1-105 subunit of the CAF-1 complex (PubMed:11533245). Interacts with brm, mor and tlk (PubMed:12381660, PubMed:14561777). Interacts with Daxx (PubMed:28320872).
messages: Highly expressed in embryos and at lower levels in larvae, pupae and adults.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10591219, PubMed:12381660, PubMed:14561777, PubMed:16151251, PubMed:16396992). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11533245). Plays a role in the formation of silent heterochromatin (PubMed:12381660, PubMed:28320872).
messages: Nucleus
messages: Phosphorylated on undefined residues by tlk.

7227:Dmel CG15862
gene id: 7227:Dmel_CG15862
uniprot id: P81900
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in follicle cells, germline-derived cells, germline line stem cells and outer rim of ring canals of nurse cells throughout oogenesis (at protein level).
messages: RNAi-mediated knockdown increases ethanol sedation sensitivity when first exposed to ethanol and decreases ethanol tolerance following repeated ethanol exposure.
messages: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (PubMed:10781603, PubMed:9196067). Mediates membrane association by binding to anchoring proteins, such as Akap200 (PubMed:9196067, PubMed:12223401). Might play an essential role in the regulation of neuronal activity in the brain (PubMed:10781603, PubMed:9196067).
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits (PubMed:9196067). In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity). Interacts with Akap200 (PubMed:10480936).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear (By similarity).

7227:Dmel CG33909
gene id: 7227:Dmel_CG33909
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG31335
gene id: 7227:Dmel_CG31335
uniprot id: Q8IN22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3973
gene id: 7227:Dmel_CG3973
uniprot id: Q9W3Y4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GAS2 family.
messages: Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons.
messages: Expressed in the ovary and the ring canals of the germline cells. In larvae, expressed in the notal region of the wing disk.
messages: Named 'Picked eggs' based upon the mutant ovary phenotype.
messages: cell cortex
messages: cytoskeleton

7227:Dmel CG7234
gene id: 7227:Dmel_CG7234
uniprot id: Q9VMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG18143
gene id: 7227:Dmel_CG18143
uniprot id: Q9VMY9
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Also has 7,8-dihydropterin deaminase activity, which plays a role in synthesis of the red eye pigment aurodrosopterin.
messages: Peak dihydropterin deaminase activity is observed in late pupae and newly eclosed adults, which correlates with the time of eye pigment formation.
messages: Strongly inhibited by p-chloromercuribenzoate (PCMB). Potassium cyanide (KCN) strongly inhibits activity towards 7,8-dihydropterin but has almost no effect on activity towards guanine. Pterin inhibits activity towards guanine but has little effect on activity towards 7,8-dihydropterin.

7227:Dmel CG11988
gene id: 7227:Dmel_CG11988
uniprot id: P29503
names: Function
names: Subcellular Location Annotation
messages: Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
messages: Nucleus

7227:Dmel CG31183
gene id: 7227:Dmel_CG31183
uniprot id: Q9VF17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

7227:Dmel CG17759
gene id: 7227:Dmel_CG17759
uniprot id: P23625
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses.
messages: Isoform D is expressed only in the retina and ocellus of the adult head. Isoform A is expressed in chemosensory cells of the olfactory and taste structures, including a subset of olfactory and gustatory neurons, and in cells of the central nervous system, including neurons in the lamina ganglionaris.

7227:Dmel CG14808
gene id: 7227:Dmel_CG14808
uniprot id: O76892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

7227:Dmel CG8069
gene id: 7227:Dmel_CG8069
uniprot id: A1Z7P3
uniprot id: Q6NL95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

7227:Dmel CG5289
gene id: 7227:Dmel_CG5289
uniprot id: A0A0B4LIJ0
uniprot id: P48601
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Interacts with PSMD5.
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

7227:Dmel CG14902
gene id: 7227:Dmel_CG14902
uniprot id: Q9VET9
names: Similarity
messages: Belongs to the peptidase C14A family.

7227:Dmel CG7597
gene id: 7227:Dmel_CG7597
uniprot id: Q9VP22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Chromosome
messages: Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation.
messages: Interacts with cyclin CycK.
messages: Nucleus

7227:Dmel CG10671
gene id: 7227:Dmel_CG10671
uniprot id: Q9VRJ2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:28067622) (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:28067622) (By similarity). Required for correct morphology of nociceptive multi-dendritic sensory neurons (PubMed:28067622). Required for normal mechanical amplification in hearing (PubMed:28067622).
messages: RNAi-mediated knockdown results in loss of auditory sensitivity (PubMed:28067622). In the whole body or specifically in muscle cells or fat body, results in locomotor impairment, uncontrolled and uncoordinated wing movements leading to flightless phenotype (PubMed:28067622). In nociceptive dorsal class IV dendritic arborization C (ddaC) neurons results in altered branching and dendritic field coverage in third instar larvae (PubMed:28067622). In fat body reduces lipid droplet size with aging (PubMed:28067622). In all neurons does not show any of the phenotypes above (PubMed:28067622).

7227:Dmel CG3477
gene id: 7227:Dmel_CG3477
uniprot id: Q01603
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Involved in the chorion hardening process, through protein cross-linking mediated by the formation of di- and tri-tyrosine bonds.
messages: Secreted

7227:Dmel CG9150
gene id: 7227:Dmel_CG9150
uniprot id: Q9VMH9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG10334
gene id: 7227:Dmel_CG10334
uniprot id: A4V0W1
uniprot id: Q01083
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed throughout the embryo.
messages: Golgi apparatus membrane
messages: Interacts with Star via the lumenal domain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.
messages: N-glycosylated and O-glycosylated.
messages: Proteolytic processing by Rhomboid occurs in the Golgi. Cleavage takes place within the transmembrane domain close to residue 144 and the active growth factor is released.

7227:Dmel CG10138
gene id: 7227:Dmel_CG10138
uniprot id: Q9W2A5
names: Similarity
messages: Belongs to the PPP phosphatase family.

7227:Dmel CG7786
gene id: 7227:Dmel_CG7786
uniprot id: A1ZAC2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10811
gene id: 7227:Dmel_CG10811
uniprot id: A8DZ29
uniprot id: O61380
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7227:Dmel CG13630
gene id: 7227:Dmel_CG13630
uniprot id: Q9VC48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

7227:Dmel CG3572
gene id: 7227:Dmel_CG3572
uniprot id: A1Z6S7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Expressed in the mesoderm during embryogenesis.
messages: Interacts with Miro.
messages: Mitochondrion
messages: Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). By interacting with Miro, promotes mitochondrial fission in response to high calcium concentrations (PubMed:27716788).
messages: RNAi-mediated knockdown perturbs mitochondrial distribution and dynamics.
messages: cytosol

7227:Dmel CG4579
gene id: 7227:Dmel_CG4579
uniprot id: Q9V463
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: Chromosome
messages: Component of the nuclear pore complex (PubMed:17410542). Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope (PubMed:22718353). In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad (PubMed:21696798). Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes (PubMed:9732281, PubMed:10511559, PubMed:17410542, PubMed:17277377). Has a role in male spermatogenesis and fertility (PubMed:9732281, PubMed:10511559). Has a role in germ line cell proliferation (PubMed:21696798).
messages: Cytoplasm
messages: Embryonic lethal (PubMed:10511559). RNAi-mediated knockdown results in failed nuclear import of phosphorylated Mad in response to activation of the dpp signaling cascade (PubMed:21696798). RNAi-mediated knockdown results in altered karyosome morphology, in the reduction of Nup62 association with the nuclear envelope and its accumulation in the cytoplasm (PubMed:26341556). RNAi-mediated knockdown of Nup62 in combination with Nup154 rescues the phenotype of the Nup62 knockdown restablishing correct kariosome morphology and chromatin detachment from the nuclear envelope (PubMed:26341556).
messages: Expressed in embryo (at protein level) (PubMed:9732281). Expressed in ovaries; more specifically in the germarium and throughout egg chamber development both in germ line and nurse cells (at protein level) (PubMed:9732281, PubMed:17410542, PubMed:17277377). Expressed in spermatocytes (at protein level) (PubMed:9732281). In embryos, detected during germ-band elongation and in the developing mesoderm (PubMed:10511559). At stage 11, mostly prominent in the central nervous system and gut (PubMed:10511559). By stage 14, detected in the brain and dorsal vessel (PubMed:10511559). At the end of embryogenesis restricted to lymph glands (hematopoietic organ), gonadal germline and specific neurons in the brain (PubMed:10511559). In larvae, detected in the imaginal disks, certain regions of the brain and all tissues containing dividing cells (PubMed:10511559). In larval, detected in testes and in all germline cells up through the meiotic stages (PubMed:10511559). In adult, detected in testes, ovaries in germanium region 2 and throughout later stage of oogenesis (PubMed:10511559).
messages: Interacts (via N-terminus) with Nup93-1 (PubMed:22718353). Interacts with Nup35 (PubMed:22718353). Interacts with cup (PubMed:17277377).
messages: Nucleus
messages: Nucleus membrane
messages: nuclear pore complex

7227:Dmel CG33128
gene id: 7227:Dmel_CG33128
uniprot id: Q9VQ12
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG7698
gene id: 7227:Dmel_CG7698
uniprot id: Q9VE51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'-end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160. Interacts with Sym and Cpsf100 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.
messages: Nucleus

7227:Dmel CG10173
gene id: 7227:Dmel_CG10173
uniprot id: Q9VRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Membrane

7227:Dmel CG40494
gene id: 7227:Dmel_CG40494
uniprot id: Q29QE1
uniprot id: X2J9V9
uniprot id: X2JC00
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

7227:Dmel CG5398
gene id: 7227:Dmel_CG5398
uniprot id: Q9W1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7227:Dmel CG10651
gene id: 7227:Dmel_CG10651
uniprot id: Q9VIN6
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG11299
gene id: 7227:Dmel_CG11299
uniprot id: A0A0B4LGG4
uniprot id: Q9W1K5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sestrin family.
messages: Cytoplasm
messages: Functions as a negative feedback regulator of TOR function.
messages: Highly expressed in muscle-enriched tissues (at protein level).
messages: Nucleus
messages: Sesn-null flies do not exhibit developmental abnormalities. However, fat bodies from third-instar larvae contain more lipids and adults also contain more triglycerides. Flies heart function is compromised with arrhythmia and decreased heart rate. Skeletal muscle undergo accelerated age-related degeneration.
messages: Up-regulated by reactive oxygen species/ROS generated, for instance, upon chronic TOR signaling activation.

7227:Dmel CG8103
gene id: 7227:Dmel_CG8103
uniprot id: E1JI46
uniprot id: M9PIA6
uniprot id: O97159
uniprot id: Q59E34
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by binding to either DNA or nucleosomes.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromosome
messages: Expressed in embryos, with levels peaking around 6 to 9 hours after egg deposition, and then sharply decreases becoming undetectable at the first larval stage (at protein level) (PubMed:18250149). Reappears at the pupal stage when it is weakly expressed (at protein level) (PubMed:18250149). Strongly expressed in adult females but expression is low to absent in adult males (at protein level) (PubMed:18250149).
messages: Helicase which acts in nucleosome-remodeling by catalyzing ATP-dependent nucleosome mobilization (PubMed:18250149). Involved in regulating transcription (PubMed:9836641, PubMed:18250149). Plays a vital role in development (PubMed:9836641). Binds to a portion of Hunchback (HB) protein that is critical for repression of bithorax complex (BXC) genes (PubMed:9836641). May also function in polycomb group (PcG) repression of Hox genes (PubMed:9836641). May also act as part of the nucleosome remodeling and deacetylase complex (the NuRD complex) which participates in the remodeling of chromatin by deacetylating histones (PubMed:18250149).
messages: Interacts with the NuRD complex member HDAC1/Rpd3.
messages: Nucleus

7227:Dmel CG1152
gene id: 7227:Dmel_CG1152
uniprot id: P18173
uniprot id: U3PT72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GMC oxidoreductase family.
messages: Essential for cuticular modification during development.
messages: Secreted

7227:Dmel CG5045
gene id: 7227:Dmel_CG5045
uniprot id: Q9VKY3
names: Similarity
messages: Belongs to the peptidase S14 family.

7227:Dmel CG4466
gene id: 7227:Dmel_CG4466
uniprot id: P02518
uniprot id: X2JC82
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG2615
gene id: 7227:Dmel_CG2615
uniprot id: Q9V3Y8
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG4843
gene id: 7227:Dmel_CG4843
uniprot id: A0A0B4KHJ9
uniprot id: H1UUJ7
uniprot id: P09491
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Homodimer.
messages: Pre-cellular embryos exhibit abnormal nuclear divisions with frequent loss of chromosome fragments. During cellularization, apico-basal polarity is also disrupted.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.

7227:Dmel CG11210
gene id: 7227:Dmel_CG11210
uniprot id: Q6NP91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

7227:Dmel CG10881
gene id: 7227:Dmel_CG10881
uniprot id: F3YDD7
uniprot id: Q9VDM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

7227:Dmel CG11739
gene id: 7227:Dmel_CG11739
uniprot id: Q9VN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria.
messages: Mitochondrion membrane

7227:Dmel CG7964
gene id: 7227:Dmel_CG7964
uniprot id: Q86NT5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

7227:Dmel CG5016
gene id: 7227:Dmel_CG5016
uniprot id: Q9VBL7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Last day of pupal development and adults.
messages: Lumen fluid of male accessory glands, becomes seminal fluid.
messages: Secreted
messages: Transferred from male to female during mating and may affect egglaying and behavior after mating.

7227:Dmel CG17324
gene id: 7227:Dmel_CG17324
uniprot id: Q9VJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG3299
gene id: 7227:Dmel_CG3299
uniprot id: O46037
uniprot id: X2JAB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Exhibits self-association properties.
messages: Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.
messages: Membrane
messages: adherens junction
messages: cytoskeleton

7227:Dmel CG7056
gene id: 7227:Dmel_CG7056
uniprot id: Q9VDF0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG40042
gene id: 7227:Dmel_CG40042
uniprot id: Q8MRW1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG33134
gene id: 7227:Dmel_CG33134
uniprot id: Q9V9C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

7227:Dmel CG2574
gene id: 7227:Dmel_CG2574
uniprot id: Q9VYN3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG11348
gene id: 7227:Dmel_CG11348
uniprot id: E8NHB5
uniprot id: P04755
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: CNS in embryos.
messages: Cell membrane
messages: Late embryonic and late pupal stages.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG34418
gene id: 7227:Dmel_CG34418
uniprot id: P91620
uniprot id: P91621
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At stage 14, expression occurs in each segment of the central nervous system. At stage 17, expression becomes restricted to the synaptic regions of the brain and ventral nerve cord, where synapses undergo maturation (PubMed:8999801). At 45 hours after puparium formation (apf) expression is enriched in the shaft of bristle cells in the sub-apical region. Present in all photoreceptors (PubMed:30290152).
messages: In the adult eye is expressed in the two primary pigment cells in the subapical region of the eye. Also present in photoreceptors.
messages: Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons (PubMed:8999801). May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation (PubMed:30290152).
messages: Synapse

7227:Dmel CG31147
gene id: 7227:Dmel_CG31147
uniprot id: P83118
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG33958
gene id: 7227:Dmel_CG33958
uniprot id: A1ZB47
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

7227:Dmel CG31482
gene id: 7227:Dmel_CG31482
uniprot id: Q9VI35
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG4584
gene id: 7227:Dmel_CG4584
uniprot id: Q8IPB1
uniprot id: Q9V3I1
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

7227:Dmel CG3803
gene id: 7227:Dmel_CG3803
uniprot id: Q9W1F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

7227:Dmel CG4338
gene id: 7227:Dmel_CG4338
uniprot id: Q9VFA0
names: Caution
names: Function
names: Similarity
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG4319
gene id: 7227:Dmel_CG4319
uniprot id: Q24475
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subunit
messages: Activator of apoptosis, as well as grim and hid, that acts on the effector Dredd.
messages: Ectopic expression in the developing eye results in a small eye owing to excess cell death.
messages: Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development.
messages: Interacts with Diap2 (via BIR2 domain).

7227:Dmel CG15881
gene id: 7227:Dmel_CG15881
uniprot id: Q7KUT5
uniprot id: Q9VW41
names: Similarity
messages: Belongs to the MIX23 family.

7227:Dmel CG6860
gene id: 7227:Dmel_CG6860
uniprot id: Q960C5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Embryos homozygous for a null allele of the gene are viable and do not display gross developmental defects, developing to adult stage, albeit with a slightly decreased viability (PubMed:20805893). Homozygous females are sterile, laying rare embryos that display no sign of development (PubMed:20805893). Mutant flies display increased lethality at extreme temperatures (PubMed:20805893).
messages: May play a role in the stabilization of the actin-rich cell cortex during cell division.
messages: There is a maternal contribution to the expression during the early stages of embryogenesis (PubMed:20805893). Zygotic expression is ubiquitous but reinforced in several embryonic tissues (PubMed:20805893). From stage 11 to 12, accumulates in the developing tracheal system, then in subsets of cells composing the central nervous system (PubMed:20805893). Finally, from stage-15, it is also strongly expressed in the gonads (PubMed:20805893).
messages: cell cortex
messages: cytoskeleton

7227:Dmel CG1913
gene id: 7227:Dmel_CG1913
uniprot id: P06603
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with Ote (PubMed:22751930).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

7227:Dmel CG34410
gene id: 7227:Dmel_CG34410
uniprot id: Q9VP48
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Partially edited. Target of Adar.
messages: Participates in exocrine secretion.

7227:Dmel CG9977
gene id: 7227:Dmel_CG9977
uniprot id: Q9VZX9
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Although it belongs to the adenosylhomocysteinase family, recombinant mouse homolog AHCYL1 expressed in bacteria shows no hydrolase activity, suggesting that Drosophila AhcyL1 may also lack this activity.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Interacts with Ahcy; the interaction may negatively regulate Ahcy catalytic activity.
messages: Might play a role in the regulation of methionine metabolism possibly by binding and inactivating Ahcy.
messages: RNAi-mediated knockdown results in extended lifespan with increased fecundity and suppression of age-related decreased climbing activity and intestinal integrity (PubMed:27313316). Does not affect oxidative stress resistance (PubMed:27313316). Decreases levels of S-adenosyl-homocysteine and homocysteine (PubMed:27313316). Suppresses histone H3K4 trimethylation (PubMed:27313316). RNAi-mediated knockdown in neurons results in extended life span (PubMed:27313316). RNAi-mediated knockdown in the fat body does not show any phenotype (PubMed:27313316). Simultaneous knockdown of AhcyL2 in intestine results in extended life span (PubMed:27313316).

7227:Dmel CG13142
gene id: 7227:Dmel_CG13142
uniprot id: Q9VKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

7227:Dmel CG10954
gene id: 7227:Dmel_CG10954
uniprot id: Q9VIM5
uniprot id: X2JAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
messages: cytoskeleton

7227:Dmel CG2062
gene id: 7227:Dmel_CG2062
uniprot id: Q9V4T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG3339
gene id: 7227:Dmel_CG3339
uniprot id: Q0KI05
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG6578
gene id: 7227:Dmel_CG6578
uniprot id: Q9VWR5
uniprot id: X2JG03
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically.
messages: First seen at the early (syncytial) blastoderm stage 4. During cellularization of the blastoderm (stage 5), stripes of expression appear and remain through to stage 10. Expression becomes undetectable during germ band retraction (stages 11-14). By stage 15, some expression resumes in the primordium of the ring gland, so that by stage 17 strong expression is seen, but only in the ring gland. This specific localization continues throughout the larval instars (at protein level). Expressed in the prothoracic gland cells of the larval ring gland (RG). Levels decline just after the molt to the third instar then increase later during the wandering stage. Low levels of expression are seen in the larval brain and fat body. In the adult, majority of expression is restricted to the ovaries, with low levels in the head and carcass of both sexes.
messages: Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.
messages: It is uncertain whether Met-1 or Met-14 is the initiator.
messages: Member of the Halloween gene group.
messages: Microsome membrane

7227:Dmel CG12242
gene id: 7227:Dmel_CG12242
uniprot id: Q9VG95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).
messages: Homodimer.

7227:Dmel CG9667
gene id: 7227:Dmel_CG9667
uniprot id: A0A0B4LGT9
uniprot id: Q9VHV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

7227:Dmel CG11887
gene id: 7227:Dmel_CG11887
uniprot id: Q7K4B3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ELP2 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in the regulation of the STAT pathway (Ref.4).
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly.
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7227:Dmel CG42565
gene id: 7227:Dmel_CG42565
uniprot id: Q9W219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG33870
gene id: 7227:Dmel_CG33870
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG8630
gene id: 7227:Dmel_CG8630
uniprot id: Q9VFX5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG3762
gene id: 7227:Dmel_CG3762
uniprot id: A4V0N4
uniprot id: Q27331
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.

7227:Dmel CG6371
gene id: 7227:Dmel_CG6371
uniprot id: Q9VG55
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pyrokinin family.
messages: Expressed during embryogenesis through to adult stages with highest expression at later half of embryogenesis and during larval stages.
messages: Expressed in a subgroup of neurosecretory cells in the subesophageal ganglion from embryonic stage 9 to larval stages.
messages: Probably has a role in larval molting.
messages: Secreted

7227:Dmel CG1112
gene id: 7227:Dmel_CG1112
uniprot id: Q9VIB5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG6628
gene id: 7227:Dmel_CG6628
uniprot id: Q9VT84
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG7289
gene id: 7227:Dmel_CG7289
uniprot id: Q9VQ60
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7125
gene id: 7227:Dmel_CG7125
uniprot id: A0A0B4KHC3
uniprot id: Q9VE91
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

7227:Dmel CG6199
gene id: 7227:Dmel_CG6199
uniprot id: Q9VTH0
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Fe(2+) ion per subunit.
messages: Endoplasmic reticulum
messages: Expressed throughout embryogenesis (at protein level). First detected at stage 12 in the haemocytes and in the fat body at stage 13 (at protein level). High levels also detected in the anal pads of stage 16 embryos (at protein level).
messages: Forms hydroxylysine residues in collagen type IV (By similarity). Required for the secretion of collagen type IV (vkg) from haemocytes, fat body and follicle cells (PubMed:23369713, PubMed:20888931).
messages: RNAi-mediated knockdown in follicle cells results in round eggs. Collagen type IV protein vkg accumulates in the basal cytoplasm of the follicle cells and is likely to cause the distended ER region in the basal cytoplasm.
messages: extracellular space

7227:Dmel CG11606
gene id: 7227:Dmel_CG11606
uniprot id: Q9VPM0
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

7227:Dmel CG10415
gene id: 7227:Dmel_CG10415
uniprot id: O96880
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.

7227:Dmel CG11357
gene id: 7227:Dmel_CG11357
uniprot id: Q9VZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG3143
gene id: 7227:Dmel_CG3143
uniprot id: A0A0B4KGN1
uniprot id: A0A126GUT4
uniprot id: Q95V55
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with melt.
messages: Mutant foxo lacking Akt1 phosphorylation sites no longer responds to insulin inhibition, remains in the nucleus, and is constitutively active, inducing cell arrest.
messages: Nucleus
messages: Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.

7227:Dmel CG7025
gene id: 7227:Dmel_CG7025
uniprot id: Q9VLZ1
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG17737
gene id: 7227:Dmel_CG17737
uniprot id: A0A1B2AJV1
uniprot id: Q9VZS3
names: Function
names: Similarity
messages: Belongs to the SUI1 family.
messages: Probably involved in translation.

7227:Dmel CG5848
gene id: 7227:Dmel_CG5848
uniprot id: Q03017
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated IKKbeta phosphorylates cact.
messages: Belongs to the NF-kappa-B inhibitor family.
messages: Cytoplasm
messages: Expressed during embryogenesis (at protein level). Isoform A is expressed in ovaries and 0-1 hour embryos. After 2-3 hours unphosphorylated zygotic protein is expressed. Between 4-8 hours phosphorylated zygotic protein is expressed. After 12 hours the amount of unphosphorylated zygotic protein increases until, by the end of embryogenesis, it is the most abundant form of cactus.
messages: Expressed in ovary (at protein level).
messages: Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.
messages: Phosphorylated isoform A binds to dorsal (dl); inhibits dl translocation to the nucleus and therefore from binding to DNA. In vitro, interacts with IKKbeta. Interacts with cactin and kappa-B-Ras.

7227:Dmel CG12358
gene id: 7227:Dmel_CG12358
uniprot id: Q9VG13
names: Similarity
messages: Belongs to the PAIP2 family.

7227:Dmel CG6182
gene id: 7227:Dmel_CG6182
uniprot id: Q9VCC4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

7227:Dmel CG6019
gene id: 7227:Dmel_CG6019
uniprot id: O18475
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNA polymerase type-A family.
messages: Expressed from before hatching of first instar larvae (at protein level).
messages: Expressed in ovaries (at protein level).
messages: Hypersensitivity to DNA-cross-linking agents (PubMed:8816490). In follicle cells, results in reduced fork progression in physiological rereplication regions necessary for the amplification of the eggshell (chorion) protein genes (PubMed:27849606). Reduces mRNA expression of chorion protein genes which results in compromised eggshell integrity and reduced egg hatching frequency (PubMed:27849606). In follicle cells, simultaneous knockout of DNAlig4 and DNApol-theta reduces rereplication origin firing (PubMed:27849606).
messages: In adult males, cleaved to produce a 100 kDa form.
messages: Multifunctional protein with both DNA polymerase and ATPase activities (PubMed:10343651, PubMed:15961355). Might have 3' to 5' exonuclease activity (PubMed:10343651). Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks (PubMed:20936147, PubMed:20617203, PubMed:28542210). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions (PubMed:20617203). Utilizes short microhomologies present in partially and fully single-stranded DNA (ssDNA) as primers for DNA synthesis (PubMed:28542210). Prefers poly(dA)/oligo(dT) as a template-primer (PubMed:10343651). The ATPase activity is necessary during interstrand cross-link (ICL) repair and has a critical role in generating templated insertions during MMEJ (PubMed:28542210). Necessary for processing DNA damage induced by oxygen and N-ethylation (PubMed:10732683, PubMed:20936147). In follicle cells, contributes to double-strand break repair at physiological rereplication forks necessary for survival of fertilized eggs (PubMed:20936147, PubMed:27849606).
messages: Nucleus
messages: Resistant to aphidicolin, but sensitive to dideoxythymindine triphosphate (ddTTP) and N-ethyl malemide (NEM).

7227:Dmel CG9304
gene id: 7227:Dmel_CG9304
uniprot id: Q9W2B3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4050
gene id: 7227:Dmel_CG4050
uniprot id: E2QCJ5
uniprot id: Q7K4B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

7227:Dmel CG1621
gene id: 7227:Dmel_CG1621
uniprot id: Q7JUZ9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG12306
gene id: 7227:Dmel_CG12306
uniprot id: P52304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cytoplasm
messages: Larval disks, brain and testis.
messages: May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828). Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288). Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288).

7227:Dmel CG7564
gene id: 7227:Dmel_CG7564
uniprot id: Q9VVI1
names: Similarity
messages: Belongs to the Luc7 family.

7227:Dmel CG6598
gene id: 7227:Dmel_CG6598
uniprot id: P46415
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

7227:Dmel CG10104
gene id: 7227:Dmel_CG10104
uniprot id: A1Z9Q9
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG2241
gene id: 7227:Dmel_CG2241
uniprot id: Q9VA54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

7227:Dmel CG6696
gene id: 7227:Dmel_CG6696
uniprot id: Q9VWR6
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG15442
gene id: 7227:Dmel_CG15442
uniprot id: M9MRC9
uniprot id: P41092
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

7227:Dmel CG9652
gene id: 7227:Dmel_CG9652
uniprot id: A0A0B4K6H0
uniprot id: A0A0B4KHI2
uniprot id: A0A126GUU2
uniprot id: P41596
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed both maternally and zygotically.
messages: Expressed in the larval and adult CNS in structures that mediate higher-order brain functions such as learning, memory and motor control: in the mushroom body neuropil and four unpaired neurons in each thoracic segment. The adult CNS has intense expression in the central complex, moderate expression in several neurosecretory cells, and weak expression in two unpaired neurons in the mesothoracic neuromere. Also seen in the somata of the optic lobes.
messages: Membrane
messages: Potency of neurotransmitter agonists in stimulating cAMP production and the lack of stimulation by other transmitters and metabolites suggests this is a D1-like receptor. Low homology to vertebrate D1 receptors suggests this may be a progenitor of the D1 receptor subfamily.
messages: Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.
messages: Simultaneous knockdown of Dop1R1 and myc restores the induced male-male courtship observed in the single myc knockdown.

7227:Dmel CG6739
gene id: 7227:Dmel_CG6739
uniprot id: M9PCG9
uniprot id: Q9VLZ6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3430
gene id: 7227:Dmel_CG3430
uniprot id: Q9VM60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity).
messages: Belongs to the MCMBP family.
messages: Interacts with the MCM complex.
messages: Nucleus

7227:Dmel CG9220
gene id: 7227:Dmel_CG9220
uniprot id: Q7KUZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7227:Dmel CG42341
gene id: 7227:Dmel_CG42341
uniprot id: H1UUF3
uniprot id: M9MRY3
uniprot id: M9MS37
uniprot id: M9MS72
uniprot id: P16905
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear.

7227:Dmel CG16987
gene id: 7227:Dmel_CG16987
uniprot id: Q9VQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Cytoplasm

7227:Dmel CG31321
gene id: 7227:Dmel_CG31321
uniprot id: Q8INF8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG30498
gene id: 7227:Dmel_CG30498
uniprot id: Q8T9B6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MESD family.
messages: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.
messages: Endoplasmic reticulum
messages: Monomer (By similarity). Interacts with Arrow and Yolkless.
messages: The LDLR maturation activity resides in the N- and C-terminal unstructured regions.

7227:Dmel CG4244
gene id: 7227:Dmel_CG4244
uniprot id: Q9Y0H4
names: Function
names: Subunit
names: Tissue Specificity
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.
messages: Expressed in pupal wings, at the boundary between vein and intervein territories.
messages: Interacts with N.

7227:Dmel CG8228
gene id: 7227:Dmel_CG8228
uniprot id: Q9VHB5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

7227:Dmel CG5254
gene id: 7227:Dmel_CG5254
uniprot id: Q9V3T2
uniprot id: X2JA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG3066
gene id: 7227:Dmel_CG3066
uniprot id: Q9V3Z2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: First detected in stage 11 embryos, in cells close to the gnathal region. At stage 13, expressed in numerous cells that are dispersed throughout the embryo. During organogenesis predominantly expressed under the cuticle in the proventricular zone close to the hindgut. In L3 larvae, expressed in the lymph glands, the hematopoietic organ that flanks the dorsal vessel and in mature hemolymph crystal cells that appear in clusters attached to diverse organs.
messages: Interacts with Spn27A.
messages: RNAi-mediated knockdown is semi-pupal lethal, with 50% of pupae dying at the late pupal stage or during eclosion (PubMed:16861233). Adults display impaired melanization at the site of septic infection (septic injury) using either Gram-negative or Gram-positive bacteria (PubMed:16256951, PubMed:16861233, PubMed:19071960). Reduced survival, PPO1 activity and induction of the antimicrobial peptide Drs following septic injury using the fungus B.bassiana (PubMed:16256951, PubMed:16861233). Septic injury with various bacteria reduces survival (L.monocytogenes, S.typhimurium and S.aureus) and in some cases decreases (E.faecelis) or increases bacterial growth (L.monocytogenes, S.typhimurium and B.cepacia). Aseptic injury reduces survival (PubMed:19071960). Aseptic wounding has no effect on survival (PubMed:22227521). Significant increase in survival after immune challenge with S.pneumoniae although there is no increase in melanization (PubMed:19071960). No effect on the survival following infection with various bacteria (E.coli, B.cepacia and E.faecelis) (PubMed:19071960). No induction of the antimicrobial peptides Drs and Dpt following infection with E.carotovora (PubMed:16861233).
messages: Secreted
messages: Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding (PubMed:16256951, PubMed:16322759, PubMed:19071960, PubMed:24260243, PubMed:16861233). May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea (PubMed:18854145, PubMed:24260243, PubMed:16322759). Important for the innate immune response to fungi (PubMed:16861233). Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway (PubMed:16861233).
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
messages: Up-regulated after wounding. Levels are higher with septic wounding, using either Gram-negative or Gram-positive bacteria.

7227:Dmel CG2543
gene id: 7227:Dmel_CG2543
uniprot id: Q9VYL1
uniprot id: X2JDF2
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

7227:Dmel CG1598
gene id: 7227:Dmel_CG1598
uniprot id: Q7JWD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.

7227:Dmel CG11430
gene id: 7227:Dmel_CG11430
uniprot id: E2QCH2
uniprot id: Q9U6B8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import.
messages: Cell membrane
messages: In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).
messages: Membrane

7227:Dmel CG13475
gene id: 7227:Dmel_CG13475
uniprot id: Q9NHP8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3284
gene id: 7227:Dmel_CG3284
uniprot id: A0A0B4K652
uniprot id: P36958
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
messages: Expressed both maternally and zygotically throughout development.
messages: nucleolus

7227:Dmel CG6697
gene id: 7227:Dmel_CG6697
uniprot id: Q9XZ16
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

7227:Dmel CG6987
gene id: 7227:Dmel_CG6987
uniprot id: Q9V3W7
names: Similarity
messages: Belongs to the splicing factor SR family.

7227:Dmel CG4768
gene id: 7227:Dmel_CG4768
uniprot id: Q9VXB1
names: Similarity
messages: Belongs to the TAPR1 family.

7227:Dmel CG3017
gene id: 7227:Dmel_CG3017
uniprot id: O18680
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

7227:Dmel CG7535
gene id: 7227:Dmel_CG7535
uniprot id: A0A0B4KHS0
uniprot id: A0A0B4LHB7
uniprot id: A0A0B4LHB9
uniprot id: A0A0B4LID6
uniprot id: E1JIQ1
uniprot id: E1JIQ2
uniprot id: Q0IGX3
uniprot id: Q94900
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.
messages: Cell membrane
messages: Channels desensitize rapidly in the continued presence of glutamate and are activated by the glutamate analog ibotenate. In Xenopus oocytes, avermectins and nodulisporic acid directly activate channel conductance.
messages: Expressed in the medulla layers (at protein level) (PubMed:31535971). Expressed in all major ON pathway medulla neurons (Mi1, Tm3, Mi4, and Mi9) and in OFF pathway neurons (Tm1, Tm2, Tm4, and Tm9) (PubMed:31535971).
messages: Expressed throughout development.
messages: Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration (PubMed:8702744, PubMed:11095718). Inhibited by picrotoxin (PubMed:31535971).
messages: Glutamate-gated chloride channel subunit (PubMed:11095718, PubMed:8702744). Together with Gamma-aminobutyric acid receptor Rdl, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons (PubMed:31535971).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Partially edited. Edited by Adar.
messages: Pentamer (By similarity). Homomultimer.
messages: Postsynaptic cell membrane
messages: Viable but with locomotor deficits (PubMed:31535971). Results in loss of light response in all neuronal layers part of the ON visual system (PubMed:31535971). In Mi1 neurons, does not affect function of the ON visual response (PubMed:31535971). RNAi-mediated knockdown in Mi1 or Tm3 neurons, does not affect function of the ON visual response (PubMed:31535971).

7227:Dmel CG14979
gene id: 7227:Dmel_CG14979
uniprot id: Q9VZL7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Expressed in the medial aspect of the third antennal segment. Carbon dioxide-responsive neurons coexpress Gr21a and Gr63a in a pair of chemosensory receptors at both larval and adult life stages.
messages: Gr21a and Gr63a probably form a heterodimer that responds to CO(2).
messages: Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a.
messages: The Myb-MuvB complex mediates neuron-specific expression of the carbon dioxide receptor genes Gr63a and Gr21a. Conversely, Mip120 and E2F2, are required for repression of Gr63a in inappropriate neurons.

7227:Dmel CG10788
gene id: 7227:Dmel_CG10788
uniprot id: P40140
names: Developmental Stage
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant during the third larval stage.
messages: Salivary gland specific.
messages: Secreted

7227:Dmel CG34042
gene id: 7227:Dmel_CG34042
uniprot id: Q86LH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG3085
gene id: 7227:Dmel_CG3085
uniprot id: Q9W1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7227:Dmel CG42492
gene id: 7227:Dmel_CG42492
uniprot id: E1JJE6
uniprot id: M9PDU2
uniprot id: M9PGH2
uniprot id: M9PGQ4
uniprot id: M9PJ56
uniprot id: Q9W4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG43867
gene id: 7227:Dmel_CG43867
uniprot id: Q9W5D0
names: Sequence Caution
messages: Contaminating sequence. Potential poly-A sequence.

7227:Dmel CG3935
gene id: 7227:Dmel_CG3935
uniprot id: Q06453
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed during embryonic development, in distinct epidermal patterns in head, thorax and abdomen and in an endodermal pattern in the anterior intestinal tract.
messages: First expressed in 4-8 hours old embryos, peaks in 8-12 hours old embryos and continues through development up to late larval stage. In the head region, detected at stage 10 in the maxillary and labial segment primordia, and in later stages, in the prospective antennal and mandibular segment. In the epidermis, expression is seen from stage 11 in thoracic and abdominal lateral patches. Expression in the intestinal tract begins at stage 13, continues through stages 14 and 15 in the endoderm of the anterior midgut and at stage 16, is found in the posterior end. Expression in the imaginal disks is seen from late third-instar larvae in the prospective thorax, claw organ, antenna, scutellum and wing blade.
messages: Flies display a reduction in size of the arista and scutellum, a reduction or complete absence of the tarsal claws, irregularities of the sternopleural bristles and of the wing vein, and a bending of the wing blade.
messages: Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development.
messages: Nucleus

7227:Dmel CG18853
gene id: 7227:Dmel_CG18853
uniprot id: A1Z758
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

7227:Dmel CG7913
gene id: 7227:Dmel_CG7913
uniprot id: A0A0B4KHB9
uniprot id: A0A0B4KHP7
uniprot id: B7Z0L6
uniprot id: B7Z0L7
uniprot id: Q0KI58
uniprot id: Q5BIJ2
uniprot id: Q8IN89
uniprot id: Q8IN90
uniprot id: Q9VEC6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7227:Dmel CG10061
gene id: 7227:Dmel_CG10061
uniprot id: Q9VI72
names: Similarity
messages: Belongs to the TCP10 family.

7227:Dmel CG30291
gene id: 7227:Dmel_CG30291
uniprot id: Q95SK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK5RAP3 family.
messages: Cytoplasm
messages: Nucleus
messages: Probable regulator of cell proliferation. May regulate CDK5, NF-kappa-B-mediated gene transcription and p53/TP53 activation.

7227:Dmel CG4402
gene id: 7227:Dmel_CG4402
uniprot id: Q9W2C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG12324
gene id: 7227:Dmel_CG12324
uniprot id: Q7KR04
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

7227:Dmel CG7218
gene id: 7227:Dmel_CG7218
uniprot id: A0A0B4LH99
uniprot id: Q9VED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

7227:Dmel CG14401
gene id: 7227:Dmel_CG14401
uniprot id: M9NDC5
uniprot id: M9PGD2
uniprot id: Q9VIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Belongs to the scoloptoxin-05 family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG6127
gene id: 7227:Dmel_CG6127
uniprot id: A0A0B4LIS1
uniprot id: P18168
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.
messages: Putative Notch ligand involved in the mediation of Notch signaling.
messages: Restricted exclusively to cells of ectodermal origin.
messages: Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
messages: Ubiquitinated by mind-bomb, leading to its endocytosis and subsequent degradation.

7227:Dmel CG5262
gene id: 7227:Dmel_CG5262
uniprot id: Q9VPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM104 family.
messages: Membrane

7227:Dmel CG4252
gene id: 7227:Dmel_CG4252
uniprot id: Q9VXG8
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Called dATM in some references while it is the ortholog of ATR.
messages: Expressed both maternally and zygotically.
messages: In embryos, during S phase of mid-blastula transition, fails to delay the activation of Cdk1, leads to loss of Rif1 foci, and results in cells entering prematurely into mitosis 13 before the completion of replication resulting in chromosome bridging.
messages: Interacts with mus304.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo. Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication. Also plays an important role during meiosis, where it may monitor double-strand-break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis.

7227:Dmel CG11626
gene id: 7227:Dmel_CG11626
uniprot id: Q9VDX1
names: Similarity
messages: Belongs to the peptidase S28 family.

7227:Dmel CG7137
gene id: 7227:Dmel_CG7137
uniprot id: Q7K2B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

7227:Dmel CG33864
gene id: 7227:Dmel_CG33864
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG9542
gene id: 7227:Dmel_CG9542
uniprot id: Q9VMC9
uniprot id: X2J8X6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

7227:Dmel CG42632
gene id: 7227:Dmel_CG42632
uniprot id: Q9VGW9
names: Subcellular Location Annotation
messages: Mitochondrion

7227:Dmel CG42264
gene id: 7227:Dmel_CG42264
uniprot id: M9NE86
uniprot id: Q9W477
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG1106
gene id: 7227:Dmel_CG1106
uniprot id: Q07171
names: Caution
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
messages: Intron retention.
messages: Isoform 1 and isoform 2 are ubiquitously expressed in early embryo. Isoform 1 is expressed in the fat body, and is abundant in hemolymph. Isoform 2 is expressed in parts of the gut.
messages: Lacks one of the cysteines to make the disulfide bridge in isoform 1. It is replaced by Val-233.
messages: Secreted
messages: cytoskeleton

7227:Dmel CG9700
gene id: 7227:Dmel_CG9700
uniprot id: A0A0B4KGT9
uniprot id: P81924
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 15% of the 120 sensory neurons within the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
messages: The strain (Berkeley) sequenced by the collaborative genome project contains a 3' deletion and is considered a pseudogene.

7227:Dmel CG18173
gene id: 7227:Dmel_CG18173
uniprot id: Q9W096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

7227:Dmel CG10862
gene id: 7227:Dmel_CG10862
uniprot id: Q9I7T6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG17610
gene id: 7227:Dmel_CG17610
uniprot id: P42287
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Critical for defining the anterior-posterior and dorsal-ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway.
messages: Expressed in nurse cells and oocyte up to oogenesis stage 7. Specifically accumulates in dorsal anterior corner of the oocyte during stages 9/10, at later stages expression is seen as an anterior ring. In stage 10 ovaries, it is concentrated between the oocyte nucleus and the adjacent oolemma. During vitellogenesis stage it can be detected at the oocyte surface, especially on the microvilli. It is also found at the microvilli covering the apical surface of the follicular epithelium and within follicle cells.
messages: Interacts with cni.

7227:Dmel CG9072
gene id: 7227:Dmel_CG9072
uniprot id: Q9VXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

7227:Dmel CG16837
gene id: 7227:Dmel_CG16837
uniprot id: Q9W168
names: Similarity
messages: Belongs to the GAMAD family.

7227:Dmel CG14358
gene id: 7227:Dmel_CG14358
uniprot id: Q4V4I9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in endocrine cells of the larval midgut (at protein level) (PubMed:24098432, PubMed:24850274). Low levels in larval brain with higher levels in larval and adult gut and adult brain (PubMed:24098432).
messages: Ligand for the CCHamide-1 receptor CCHa1-R.
messages: No effect on developmental timing or on levels of the insulin-like peptides Ilp2 and Ilp3.
messages: Secreted
messages: Very low expression in eggs. Expression increases during larval stages, decreases in pupae and increases again in adults.

7227:Dmel CG3808
gene id: 7227:Dmel_CG3808
uniprot id: Q9VVV7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG10192
gene id: 7227:Dmel_CG10192
uniprot id: Q9VCH1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7227:Dmel CG6707
gene id: 7227:Dmel_CG6707
uniprot id: Q9VT68
uniprot id: Q9VT69
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

7227:Dmel CG31676
gene id: 7227:Dmel_CG31676
uniprot id: Q9VII5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG30157
gene id: 7227:Dmel_CG30157
uniprot id: A0A0B4LFP9
uniprot id: Q4V6M7
names: Function
names: Similarity
messages: Belongs to the peptidase C78 family.
messages: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins.

7227:Dmel CG4851
gene id: 7227:Dmel_CG4851
uniprot id: Q9VKH6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Expressed in adult head and crop.
messages: Low level expression is detected in embryonic development with no distinct tissue specific enrichment. Expression levels increase at third larval instar stage and continue through to adulthood.
messages: Lysosome
messages: Probable thioesterase removing fatty acyl groups from various substrates such as S-palmitoyl-CoA. Because of structural constraints, may be unable to remove palmitate from peptides or proteins (By similarity).

7227:Dmel CG4428
gene id: 7227:Dmel_CG4428
uniprot id: M9PBM3
uniprot id: Q9VPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

7227:Dmel CG11098
gene id: 7227:Dmel_CG11098
uniprot id: Q9VMA7
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIA/OTOR family. Tango1 subfamily.
messages: Deletion of 12 residues at position 1268 causing a frameshift.
messages: Deletion of 172 residues at position 924.
messages: Golgi apparatus membrane
messages: RNAi-mediated knockdown results in basal membrane proteins such as vkg, LanB1 and Trol accumulating in the basal ER.
messages: Required for protein secretion (PubMed:16452979, PubMed:23369713). May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier (PubMed:16452979). At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters (PubMed:23369713).
messages: trans-Golgi network

7227:Dmel CG32495
gene id: 7227:Dmel_CG32495
uniprot id: Q86B44
uniprot id: Q8IQZ1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

7227:Dmel CG3821
gene id: 7227:Dmel_CG3821
uniprot id: Q7K0E6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

7227:Dmel CG12782
gene id: 7227:Dmel_CG12782
uniprot id: Q9W1T0
names: Similarity
messages: Belongs to the WD repeat rae1 family.

7227:Dmel CG7115
gene id: 7227:Dmel_CG7115
uniprot id: D8FT19
uniprot id: M9PCH3
uniprot id: Q9XZ28
names: Similarity
messages: Belongs to the PP2C family.

7227:Dmel CG10626
gene id: 7227:Dmel_CG10626
uniprot id: Q9VRM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7227:Dmel CG17285
gene id: 7227:Dmel_CG17285
uniprot id: Q04691
names: Developmental Stage
names: Induction
names: Tissue Specificity
messages: By ecdysone.
messages: Expressed during the late third larval stage.
messages: Fat body.

7227:Dmel CG7610
gene id: 7227:Dmel_CG7610
uniprot id: O01666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

7227:Dmel CG7593
gene id: 7227:Dmel_CG7593
uniprot id: Q9VAI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG32063
gene id: 7227:Dmel_CG32063
uniprot id: Q961W5
names: Similarity
messages: Belongs to the peptidase M17 family.

7227:Dmel CG13375
gene id: 7227:Dmel_CG13375
uniprot id: Q9W5G7
uniprot id: X2JC14
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2970
gene id: 7227:Dmel_CG2970
uniprot id: Q9W1F7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7227:Dmel CG4817
gene id: 7227:Dmel_CG4817
uniprot id: B5RJ65
uniprot id: Q05344
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant throughout oogenesis and embryogenesis, decreases during larval stages and increases again in pupae.
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.
messages: Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp. Interacts with CHD1 and TRL/GAGA.
messages: Expressed at highest levels in nurse cells of the ovary.
messages: Nucleus
messages: nucleolus

7227:Dmel CG42685
gene id: 7227:Dmel_CG42685
uniprot id: Q9VJS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG5911
gene id: 7227:Dmel_CG5911
uniprot id: Q86C62
uniprot id: Q9VDC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

7227:Dmel CG31741
gene id: 7227:Dmel_CG31741
uniprot id: Q9VJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG10305
gene id: 7227:Dmel_CG10305
uniprot id: M9PG47
uniprot id: P13008
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

7227:Dmel CG6475
gene id: 7227:Dmel_CG6475
uniprot id: Q9VDA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG2277
gene id: 7227:Dmel_CG2277
uniprot id: Q961B3
uniprot id: X2JCB6
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7227:Dmel CG7614
gene id: 7227:Dmel_CG7614
uniprot id: Q7KPG8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

7227:Dmel CG1422
gene id: 7227:Dmel_CG1422
uniprot id: Q9W3N6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Cytoplasm
messages: Detected in embryos and larvae (at protein level) (PubMed:12876273). Expressed in larval imaginal disks (at protein level) (PubMed:11514618).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae.
messages: Golgi stack
messages: Golgi stack membrane
messages: RNAi-mediated knockdown results in a loss of Golgi stacks and affects the organization of the transitional ER (tER) sites. Golgi stacks break down and form clusters of vesicles and tubules. The Golgi stacks that are present have an adherent morphology, including a decrease in stack diameter and total cisternae (stacked and single). The tER sites lose their organization and become dispersed throughout the cytoplasm. However, the efficiency of anterograde intracellular transport is not affected.

7227:Dmel CG18301
gene id: 7227:Dmel_CG18301
uniprot id: Q9VKT8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG11138
gene id: 7227:Dmel_CG11138
uniprot id: B7Z143
uniprot id: M9PHN7
uniprot id: Q9VYL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

7227:Dmel CG1759
gene id: 7227:Dmel_CG1759
uniprot id: M9PDI3
uniprot id: P09085
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Caudal homeobox family.
messages: Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora.
messages: Expressed both maternally and zygotically.
messages: Maternally localized in an anteroposterior gradient in the syncytial blastoderm. Also expressed in the pole cells. Zygotically localized in the primordia of the terminal abdominal segment, the hindgut and in the posterior midgut rudiment. Expressed in the gut, the gonads and parts of the genital disks of third instar larvae (at protein level).
messages: Nucleus

7227:Dmel CG30390
gene id: 7227:Dmel_CG30390
uniprot id: Q9W2I4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG40452
gene id: 7227:Dmel_CG40452
uniprot id: P36975
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNAP-25 family.
messages: Exclusively found in brain and ganglia.
messages: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity).
messages: synaptosome

7227:Dmel CG33871
gene id: 7227:Dmel_CG33871
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG17521
gene id: 7227:Dmel_CG17521
uniprot id: M9PIM0
uniprot id: O61231
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).

7227:Dmel CG12068
gene id: 7227:Dmel_CG12068
uniprot id: Q9VAH3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG4647
gene id: 7227:Dmel_CG4647
uniprot id: F3YDM8
uniprot id: Q9VYI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG42318
gene id: 7227:Dmel_CG42318
uniprot id: A2VEY9
uniprot id: Q9VTV6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Detected in embryo, imaginal disks and pupal wings (at protein level) (PubMed:18804377). Enriched in the somatic musculature and gut throughout embryonic development (PubMed:18719403).
messages: Endoplasmic reticulum membrane
messages: Interacts with Dlish (via N-terminus including SH3 domain 1); this leads to palmitoylation of Dlish by app. Interacts with ft; this is likely to interfere with the interaction between app and Dlish, reducing the ability of app to palmitoylate Dlish and tether it to the apical cell cortex.
messages: Membrane
messages: Palmitoylates Dlish which is required for the apical cell cortex localization, total cellular level and full activity of dachs.
messages: Semi-lethal in homozygotes and heterozygotes with adult escapers showing abdominal planar cell polarity defects and also extensive wing planar cell polarity defects, both proximally and in a distal region between the third and fourth longitudinal veins. Greatly reduced accumulation of dachs at the apical cell cortex.
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG18234
gene id: 7227:Dmel_CG18234
uniprot id: Q9VVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG40050
gene id: 7227:Dmel_CG40050
uniprot id: Q1JUZ1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cholesterol 7-desaturase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol (PubMed:21632547). Essential regulator of steroid biosynthesis, as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid (PubMed:21632547, PubMed:16763204). Required for insect molting, metamorphosis and body growth throughout development via the regulation of ecdysteroid biosynthesis in the prothoracic gland (PubMed:16763204).
messages: Expressed predominantly in the prothoracic gland and weakly in brain and malpighian tubules.
messages: Membrane
messages: Nvd_Dm plays a pivotal role in larval development in Drosophila. On this basis of the prolonged first instar larval phenotype, the gene was named 'neverland', which is the fictional island featured in J. M. Barrie's play Peter Pan, where children cease to age.
messages: RNAi animals show apparent growth arrest in body size compared with control animal, also loss of nvd-Dm function prevents larval growth prior to the initiation of the molting process.

7227:Dmel CG1683
gene id: 7227:Dmel_CG1683
uniprot id: O62526
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

7227:Dmel CG13516
gene id: 7227:Dmel_CG13516
uniprot id: Q2PE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG10855
gene id: 7227:Dmel_CG10855
uniprot id: Q8SX86
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, at least composed of ntc, skpA and Cul1. Interacts (via F-box domain) with skpA and Cul1. Interacts with Prosalpha7 and PI31. Interacts with Bruce.
messages: Cytoplasm
messages: Expressed in testis (at protein level).
messages: Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability.
messages: Male sterility.

7227:Dmel CG17352
gene id: 7227:Dmel_CG17352
uniprot id: Q8IQA8
uniprot id: Q8IQA9
uniprot id: Q9VSI3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7793
gene id: 7227:Dmel_CG7793
uniprot id: P26675
names: Function
names: Subunit
messages: May form a complex with sevenless and DRK.
messages: Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.

7227:Dmel CG9458
gene id: 7227:Dmel_CG9458
uniprot id: Q9VH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG32146
gene id: 7227:Dmel_CG32146
uniprot id: Q7KUL1
uniprot id: Q9VUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

7227:Dmel CG3766
gene id: 7227:Dmel_CG3766
uniprot id: Q9VLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization.
messages: trans-Golgi network

7227:Dmel CG4472
gene id: 7227:Dmel_CG4472
uniprot id: Q8MM24
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
messages: Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.
messages: Expressed both maternally and zygotically. Expressed throughout development, with a much stronger expression during larval stages.
messages: Lacks the typical Glu active site in position 150 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.
messages: Primarily expressed in yolk cells and fat body. In larvae, it is expressed in large salivary gland cells and weakly expressed in imaginal disks. Less expressed than Idgf2 and Idgf4.
messages: Secreted

7227:Dmel CG7354
gene id: 7227:Dmel_CG7354
uniprot id: Q9VVN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7227:Dmel CG1789
gene id: 7227:Dmel_CG1789
uniprot id: Q9W3C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

7227:Dmel CG10798
gene id: 7227:Dmel_CG10798
uniprot id: Q9W4S7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Efficient DNA binding requires dimerization with another bHLH protein (PubMed:8929412). Binds DNA as a heterodimer with Max (PubMed:8929412). Interacts with ago (PubMed:15182669, PubMed:24173801). Interacts with lid (PubMed:17311883). Part of a complex containing lid, Myc and ash2 (PubMed:17311883). Component of a complex with pont and rept (PubMed:16087886). Interacts with puf (PubMed:24173801).
messages: Expressed both maternally and zygotically in embryos.
messages: Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature.
messages: Nucleus
messages: Participates in the regulation of gene transcription (PubMed:8929412, PubMed:16087886, PubMed:24173801, PubMed:24615015, PubMed:25999153, PubMed:25858587). Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG (PubMed:8929412). Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth (PubMed:16087886, PubMed:25999153, PubMed:25858587). Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex (PubMed:25999153). Inhibits the demethylase activity of Lid (PubMed:17311883). Activates transcription of mbm (PubMed:24615015). Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1 (PubMed:25858587). Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation (PubMed:15182669, PubMed:24173801). It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf (PubMed:24173801). In dopaminergic neurons, regulates dopamine levels by binding to the E-box (E1) of the dopamine decarboxylase Ddc promoter and thereby inhibiting its transcription (PubMed:35167135). This regulation is required to suppress male-male courtship (PubMed:35167135).
messages: Probably targeted for ubiquitination by the SFC ubiquitin ligase complex member ago, leading to its proteasomal degradation.
messages: RNAi-mediated knockdown in the neurons, only dopaminergic neurons or only adult neurons increases transcription of the dopamine decarboxylase Ddc and thereby dopamine concentration (PubMed:35167135). In addition, induces male courtship propensity towards other males without altering male sexual preference towards females (PubMed:35167135). RNAi-mediated knockdown in muscle or fat body does not elicit male-male courtship (PubMed:35167135). Simultaneous knockdown of Ddc and myc restores increased dopamine levels and the induced male-male courtship observed in the single myc knockdown (PubMed:35167135). Simultaneous knockdown of dopamine receptor Dop1R1 and myc restores the induced male-male courtship observed in the single myc knockdown (PubMed:35167135).

7227:Dmel CG10209
gene id: 7227:Dmel_CG10209
uniprot id: A0A0B4KEQ7
uniprot id: Q7K3Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Nucleus
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG9169
gene id: 7227:Dmel_CG9169
uniprot id: Q9W0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7227:Dmel CG3688
gene id: 7227:Dmel_CG3688
uniprot id: Q9VJQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Nucleus
messages: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity).

7227:Dmel CG1262
gene id: 7227:Dmel_CG1262
uniprot id: O46202
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Produced in the male genital tract (at protein level) (PubMed:10612039). Present in seminal fluid (PubMed:9474779). Transferred to the female genital tract within the first 3 minutes after the start of mating (ASM) and crosses the posterior vaginal wall into the female hemolymph 5 minutes ASM (at protein level) (PubMed:10612039).
messages: Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.
messages: Secreted

7227:Dmel CG1401
gene id: 7227:Dmel_CG1401
uniprot id: Q9VAQ0
names: Similarity
messages: Belongs to the cullin family.

7227:Dmel CG6824
gene id: 7227:Dmel_CG6824
uniprot id: P51521
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adult lethal (PubMed:12915226). In the rare adult escapers, trichomes are often absent from large areas of the thorax and wing, or they are sparse and atrophied (PubMed:12915226). In the aristae, the central core is shorter and lateral cells either fail to develop or are strongly reduced in size (PubMed:12915226). Embryos display a smooth cuticle with sparse atrophied denticles (PubMed:12915226). Isoform D: No visible phenotype (PubMed:3428601). Isoform D: Males are viable whereas females are sterile and do not lay eggs (PubMed:3428601). Isoform D: Ovaries are atrophic and slightly larger than the oviducts at the posterior end of the ovaries, and egg chambers and germline cells are not visible (PubMed:3428601). Isoform D: In female embryos undergoing gastrulation, pole cells undergo cell death and are consequently either absent or reduced in number (PubMed:3428601). Isoform D: Pole cell morphology and their position in the embryo is unaffected (PubMed:3428601). Isoform D: Embryonic germline cells are unaffected while, in female larvae, germline cells undergo cell death and by the third instar stage, the germline cells in most mutants are either absent or reduced in number whereas, in the remaining mutants, the number of germline cells are not affected (PubMed:8652413). Isoform B: RNAi-mediated knockdown results in reduced expression of miniature (m) in the developing embryo (PubMed:28506986).
messages: Cytoplasm
messages: Expressed both maternally and zygotically (PubMed:7935398, PubMed:9012532, PubMed:1712294, PubMed:17246162, PubMed:28059165). Isoform B: Expressed in the notum from early pupation to 36 h after puparium formation, disappearing once epidermal cells develop apical extensions (at protein level) (PubMed:25344753). Isoform B: Expressed in the trichomes of stages 11 and 12 embryos and disappears by stage 15 but the cleaved transcriptional activator form svb is still present (at protein level) (PubMed:20647469). Isoform B: Not detected until the blastoderm stage when it is expressed in the head (PubMed:7748792). Isoform B: No expression in the primordial germ cells (PGCs) (PubMed:28059165). Isoform B: In stage 12 embryos, expressed in the trunk, and in stage 14 embryos expressed in the region of denticle belt setae and dorsal hairs (PubMed:7748792). Isoform B: Not detected in the pole cells throughout embryogenesis (PubMed:7748792). Isoform B: Expressed in the pupal tarsal segments in several segmentally separated stripes (PubMed:21527259). Isoform D: Expressed in the germinal stem cells of the germarium and later in the nurse cells (at protein level) (PubMed:7748792). Isoform D: Uniformly expressed in early cleavage and blastoderm stage embryos (at protein level) (PubMed:7748792). Isoform D: At germ band extension (stage 8), expression levels decrease rapidly and becomes localized to the pole cells in the posterior midgut pocket (at protein level) (PubMed:7748792). Isoform D: In stage 14 embryos, expressed in the forming gonads and some dispersed cells presumed to be pole cells lost during cell migration (at protein level) (PubMed:7748792). Isoform D: Expressed in male and female embryos, and in the germ cell in the gonads of male and female larvae (at protein level) (PubMed:7748792). Isoform D: Detected in adults, and in males is expressed in the apical part of each testis (at protein level) (PubMed:7748792). Isoform D: Expressed during early oogenesis in all female germ…
messages: Interacts (via N-terminus) with Ubr3; the interaction is mediated by tal.
messages: N-terminus is proteolytically cleaved and ubiquitinated via a tal-dependent mechanism, leading to the proteolytic degradation of the N-terminus and the production of transcriptional activator shavenbaby, a truncated form with transcriptional activator activity.
messages: Nucleus
messages: Only 3 of the 4 C2H2-type zinc-fingers are required for DNA-binding. Based on its marked lack of evolutionary conservation, the fourth zinc-finger is unlikely to be required.
messages: Produced by alternative promoter usage and alternative splicing.
messages: Produced by alternative promoter usage.
messages: Transcriptional activator which initiates trichome development and also promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). Has an essential somatic role regulating the tal-dependent formation of trichomes, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:20647469, PubMed:21527259, PubMed:25344753, PubMed:26383956). Function with SoxN is required for correct denticle morphogenesis on the embryonic epidermis (PubMed:28506986). SoxN and svb appear to act both independently and in conjunction with each other to activate certain genes involved in denticle morphogenesis; Svb appears to be involved in regulating denticle length whereas SoxN regulates the denticle base circumference (PubMed:28506986). Also functions in the development of other apical cell extensions such as bristles (PubMed:25344753). Also has an important role in tarsal joint development, repressing expression of the N ligand Dl and defining its signaling boundary (PubMed:21527259).
messages: Transcriptional activator which is specifically involved in female germline development, where it functions antagonistically to isoform C (PubMed:10648246, PubMed:1712294, PubMed:3428601, PubMed:8652413). Necessary and sufficient for normal oogenesis (PubMed:1712294, PubMed:12051822). Required in the primordial germ cells (PGCs) for normal development of male and female germline cells (PubMed:28059165). Plays a role in germline sex determination (PubMed:2116356). Binds the promoter DNA and positively regulates the transcription of the otu gene in a stage-specific manner (PubMed:10525184, PubMed:11290304, PubMed:9634487). May have autoregulatory activity (PubMed:11290304, PubMed:9634487).
messages: Transcriptional regulator with essential functions in the germline and soma (PubMed:9012532, PubMed:12915226, PubMed:10421370). Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:12915226, PubMed:10421370).
messages: Transcriptional repressor which functions in postembryonic development (PubMed:21527259, PubMed:26383956). The full-length unprocessed form acts as a transcriptional repressor (Transcriptional repressor svb) (PubMed:26383956).
messages: Transcriptional repressor which is specifically involved in female germline development, where it functions antagonistically to isoform D (PubMed:10648246, PubMed:28059165). Negatively regulates expression of otu and may also have autoregulatory activity (PubMed:10648246). Negatively regulates expression of piwi in the primordial germ cells (PGCs) (PubMed:28059165).
messages: nucleoplasm

7227:Dmel CG9849
gene id: 7227:Dmel_CG9849
uniprot id: Q9W1W9
names: Function
names: Subcellular Location Annotation
messages: May be involved in iversification of muscle cell fates.
messages: Secreted

7227:Dmel CG17498
gene id: 7227:Dmel_CG17498
uniprot id: Q9VRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAD2 family.
messages: Nucleus

7227:Dmel CG9573
gene id: 7227:Dmel_CG9573
uniprot id: Q9VLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

7227:Dmel CG4025
gene id: 7227:Dmel_CG4025
uniprot id: O77262
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG34342
gene id: 7227:Dmel_CG34342
uniprot id: A8JNC9
uniprot id: E2QCY5
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG4626
gene id: 7227:Dmel_CG4626
uniprot id: A4V438
uniprot id: Q9NBW1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
messages: The FZ domain is involved in binding with Wnt ligands.

7227:Dmel CG9749
gene id: 7227:Dmel_CG9749
uniprot id: A0A0B4K774
uniprot id: A0A0B4KH51
uniprot id: Q9Y0S9
names: Similarity
messages: Belongs to the ABI family.

7227:Dmel CG42803
gene id: 7227:Dmel_CG42803
uniprot id: A0A0B4KFP4
uniprot id: Q8INR6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Expressed in embryos, larvae and adults.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Was named 'grappa' because the eyes of mutant flies are of a color similar to that of the Italian spirit.

7227:Dmel CG6512
gene id: 7227:Dmel_CG6512
uniprot id: Q8IQQ9
uniprot id: Q8T4G5
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

7227:Dmel CG8345
gene id: 7227:Dmel_CG8345
uniprot id: A0A0B4LEU2
uniprot id: Q9V9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG32944
gene id: 7227:Dmel_CG32944
uniprot id: Q0KID3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG3153
gene id: 7227:Dmel_CG3153
uniprot id: Q9VFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

7227:Dmel CG8646
gene id: 7227:Dmel_CG8646
uniprot id: Q8SZ72
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG2681
gene id: 7227:Dmel_CG2681
uniprot id: Q9W4W4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

7227:Dmel CG4372
gene id: 7227:Dmel_CG4372
uniprot id: Q9W2C3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

7227:Dmel CG7415
gene id: 7227:Dmel_CG7415
uniprot id: Q9VHR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues.
messages: Membrane

7227:Dmel CG30069
gene id: 7227:Dmel_CG30069
uniprot id: A1Z9M5
names: Similarity
messages: Belongs to the FAM154 family.

7227:Dmel CG8137
gene id: 7227:Dmel_CG8137
uniprot id: Q9VLQ7
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG9070
gene id: 7227:Dmel_CG9070
uniprot id: Q7JZV0
names: Function
messages: Component of the larval cuticle.

7227:Dmel CG1520
gene id: 7227:Dmel_CG1520
uniprot id: Q86B74
uniprot id: Q9VAT0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG18647
gene id: 7227:Dmel_CG18647
uniprot id: Q9VS05
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to DNA.
messages: Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer and drives expression of Ndg in the late visceral musculature. May be involved in the transcriptional regulation of wupA in the visceral mesoderm. Plays an indirect role in the later stages of salivary gland positioning.
messages: First detected at 10 dpc, when it is expressed in progenitors of all three types of visceral musculature including in primordia of the circular midgut muscles, in foregut and hindgut visceral mesoderm primordia and in the caudal visceral mesoderm. At 10 dpc to 11 dpc, it is detected in nuclei of cells of the presumptive visceral mesoderm. At 12 dpc, expression persists in trunk and hindgut visceral mesoderm. By 14 dpc, expressed in both circular and longitudinal precursors of midgut muscles, and by 16 dpc, expressed in foregut, midgut and hindgut visceral muscles (at protein level). First detected at the embryonic syncytial blastoderm stage.
messages: In embryo, expressed in all types of visceral muscles and their progenitors (at protein level). In late stage 10 embryo, expressed in the caudal visceral mesoderm and trunk and hindgut visceral mesoderm progenitors.
messages: Nucleus

7227:Dmel CG2691
gene id: 7227:Dmel_CG2691
uniprot id: Q9VYA7
uniprot id: X2JEW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP12 family.
messages: Nucleus

7227:Dmel CG31855
gene id: 7227:Dmel_CG31855
uniprot id: Q8IP73
names: Similarity
messages: Belongs to the DDA1 family.

7227:Dmel CG3691
gene id: 7227:Dmel_CG3691
uniprot id: Q9W123
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Interacts with Zeste.
messages: Nucleus
messages: Probable RNA-binding protein that specifically binds to the fourth chromosome and may bind an RNA that spreads the fourth chromosome. May be a reminiscence of X chromosome dosage compensation of ancestral Drosophila species in which the X and the fourth chromosomes are one single chromosome.
messages: Weakly expressed in embryos. Expression increases during larval and pupal stages. In adults, it is predominantly expressed in males, while it is weakly expressed in females.

7227:Dmel CG13399
gene id: 7227:Dmel_CG13399
uniprot id: Q9V444
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes (PubMed:10856248, PubMed:11447119, PubMed:18327268). Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin (PubMed:10856248, PubMed:11447119). As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf (PubMed:16260604). Has a role in DNA damage response by preventing cid mislocalization to chromatin (PubMed:24703848).
messages: Expressed in oocytes and in the early embryo and down-regulated afterwards (at protein level).
messages: Homodimer (PubMed:18327268). Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit PolE1/DNApol-epsilon255 and the accessory subunits PolE2/DNApol-epsilon58, Chrac-14/DNApolE3 and PolE4 (By similarity). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Forms an heterodimer with Chrac-16 (PubMed:10856248, PubMed:16260604). The Chrac-14/Chrac-16 heterodimer interacts with Acf (via N-terminus) (PubMed:16260604). Interacts directly with Iswi and this interaction is further stabilized by association with Chrac-16 (PubMed:10856248). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268). Interacts with cid (PubMed:24703848).
messages: Nucleus

7227:Dmel CG1311
gene id: 7227:Dmel_CG1311
uniprot id: M9PHD2
uniprot id: Q9VZE7
uniprot id: U3PXB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7227:Dmel CG15324
gene id: 7227:Dmel_CG15324
uniprot id: Q9W3P2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6510
gene id: 7227:Dmel_CG6510
uniprot id: P41093
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

7227:Dmel CG5658
gene id: 7227:Dmel_CG5658
uniprot id: Q9VB25
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Diffuse movement of Sara-expressing endosomes, failed targeting of Sara-expressing endosomes to the central spindle and symmetric endosome localization in daughter SOP cells.
messages: Early endosome
messages: Interacts with Atg8a and Rab14.
messages: Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14 (PubMed:26763909).

7227:Dmel CG13061
gene id: 7227:Dmel_CG13061
uniprot id: Q9VV28
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG4553
gene id: 7227:Dmel_CG4553
uniprot id: Q9VBR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

7227:Dmel CG2990
gene id: 7227:Dmel_CG2990
uniprot id: Q8IRL9
uniprot id: Q9W2Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

7227:Dmel CG32379
gene id: 7227:Dmel_CG32379
uniprot id: Q9VS65
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG15110
gene id: 7227:Dmel_CG15110
uniprot id: Q9XZ08
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Expressed throughout the developmental stages in both head and body from males and females.
messages: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens.
messages: Golgi apparatus membrane
messages: In wing imaginal disk, it is ubiquitously expressed.
messages: Interacts with sau.

7227:Dmel CG4330
gene id: 7227:Dmel_CG4330
uniprot id: Q9VYG7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG14980
gene id: 7227:Dmel_CG14980
uniprot id: Q9VZL5
names: Similarity
messages: Belongs to the CCZ1 family.

7227:Dmel CG9888
gene id: 7227:Dmel_CG9888
uniprot id: E4NKN3
uniprot id: Q9W1V3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
messages: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.
messages: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).
messages: nucleolus

7227:Dmel CG6155
gene id: 7227:Dmel_CG6155
uniprot id: B6IDM7
uniprot id: P48604
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
messages: Mitochondrion matrix
messages: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, Roe1, TIM44, blp/TIM16 and TIM14.

7227:Dmel CG10789
gene id: 7227:Dmel_CG10789
uniprot id: P40141
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG6443
gene id: 7227:Dmel_CG6443
uniprot id: Q9VKR2
names: Similarity
messages: Belongs to the rtf2 family.

7227:Dmel CG8509
gene id: 7227:Dmel_CG8509
uniprot id: Q9VXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG1925
gene id: 7227:Dmel_CG1925
uniprot id: Q9GSR1
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: As the catalytic subunit of the DNA polymerase zeta complex, plays a crucial role in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:11267835, PubMed:16507570, PubMed:22532806, PubMed:15175013). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function (PubMed:15175013). During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase eta to initiate repair synthesis which is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806). May participate in the Rrp1-dependent base excision repair (BER) pathway responsible for repair of DNA lesions that gives rise to apurinic/apyrimidinic (AP) sites (PubMed:16507570). Unlike mammalian orthologs, it is not an error-prone polymerase (PubMed:15175013).
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalytic subunit of the zeta DNA polymerase complex, which consists of PolZ1/DNApol-zeta and the accessory component PolZ2/Rev7 (PubMed:16507570, PubMed:15175013). Interacts with the apurinic/apyrimidinic (AP) endonuclease Rrp1; the interaction is likely indirect and mediated via PolZ2 (PubMed:16507570).
messages: Expressed in embryos (at protein level) (PubMed:15175013). Expressed throughout development, with highest levels of expression in 0-8 hour embryos and adult females (PubMed:16507570).
messages: Inhibited by tetracyclic diterpene antibiotic aphidicolin.

7227:Dmel CG34340
gene id: 7227:Dmel_CG34340
uniprot id: A0AVV3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4842
gene id: 7227:Dmel_CG4842
uniprot id: Q9VV47
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG42236
gene id: 7227:Dmel_CG42236
uniprot id: A0A0B4K851
uniprot id: A0A0B4KFL0
uniprot id: A0A126GUM4
uniprot id: Q4Z8K6
uniprot id: X5D3H6
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RANBP9/10 family.
messages: Cytoplasm
messages: Expressed in the GSCs and in dividing cysts. Expression is reduced in the germline as individual egg chambers are formed. Isoform C is expressed in all somatic and germline cells of the ovary. Isoform D is expressed in the GSC niche.
messages: Intron retention.
messages: Lack of isoform D causes an increase in niche cell size and abnormal terminal filament organization. This in turn increases niche capacity by increasing the potential contact surface between CpCs and stem cells. Lack of isoform C causes defects in the organization of the follicle cell layer and defects in dorsal appendage morphogenesis.
messages: May be involved in JAK/STAT signaling. Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche. The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC). Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity to support stem cells, isoform C and isoform D are important factors in mediating this regulation. In contrast, isoform C acts as a positive regulator of cell adhesion in follicle cell epithelium.
messages: Membrane
messages: Nucleus

7227:Dmel CG4495
gene id: 7227:Dmel_CG4495
uniprot id: A2VEI2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICU1 family. MICU1 subfamily.
messages: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult (PubMed:27568554).
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: RNAi-mediated knockdown results in lethality (PubMed:27568554). RNAi-mediated knockdown in neurons shortens lifespan and severely impairs climbing ability (PubMed:28198506). RNAi-mediated knockdown in the developing eye decreases ommatidia number and disrupts ommatidial array (PubMed:28198506). RNAi-mediated knockdown in neurons and, more specifically, in alpha/beta or gamma mushroom body neurons, impairs mitochondrial calcium entry and decreases intermediate-term memory after conditioning (PubMed:27568554). Does not affect olfactory learning (PubMed:27568554).

7227:Dmel CG34086
gene id: 7227:Dmel_CG34086
uniprot id: B6E0Q1
uniprot id: P18934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

7227:Dmel CG14142
gene id: 7227:Dmel_CG14142
uniprot id: E1JID2
uniprot id: E1JID3
uniprot id: Q9VTG6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

7227:Dmel CG17767
gene id: 7227:Dmel_CG17767
uniprot id: Q9Y0V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity).
messages: Component of the TIM22 complex, whose core is composed of Tim22, associated with peripheral protein Tim9b/Tim10b and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10 (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of Tim9b/Tim10b from the cytoplasm into the mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across the mitochondrial outer membrane (By similarity).

7227:Dmel CG11737
gene id: 7227:Dmel_CG11737
uniprot id: Q9VHQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

7227:Dmel CG18749
gene id: 7227:Dmel_CG18749
uniprot id: Q8MSK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG9958
gene id: 7227:Dmel_CG9958
uniprot id: N0BKF4
uniprot id: Q9VQF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPIN family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted, Pldn and Snapin. Interacts with Blos2 and Dysb.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis (PubMed:20015953). May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
messages: Membrane
messages: cytosol

7227:Dmel CG10842
gene id: 7227:Dmel_CG10842
uniprot id: Q9V558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG5362
gene id: 7227:Dmel_CG5362
uniprot id: Q9VKX2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

7227:Dmel CG18176
gene id: 7227:Dmel_CG18176
uniprot id: Q9VT41
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 7 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Essential for development (PubMed:19326441, PubMed:21078872). Required for cell signaling and/or cell proliferation (PubMed:19326441).
messages: Cytoplasm
messages: Expressed at low levels. First detected after cellularization, in the early epidermal tissues of embryos undergoing gastrulation. At later stages of embryogenesis, strongest expression is in the gut, and there is also expression in the central nervous system and perhaps the peripheral nervous system.
messages: Nucleus
messages: The name 'deflated' originates from the 'deflated balloon' appearance of mutant abdomens.

7227:Dmel CG7749
gene id: 7227:Dmel_CG7749
uniprot id: Q9VW71
uniprot id: X2JCN4
names: Caution
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Contaminating sequence. Potential poly-A sequence.
messages: Defects in actin filament orientation correlate with a failure of egg chambers to elongate during oogenesis (PubMed:19906848). In follicle cells, Rab10 protein polarizes normally along the apical-basal axis, but is mislocalized within the epithelial plane (PubMed:23369713). Epithelia migration is impaired and the structure of the basal membrane is disrupted (PubMed:23369713).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Localizes where basal actin filaments terminate.
messages: Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells (PubMed:19906848, PubMed:23369713). Required for proper egg chamber shape and elongation of the egg chamber during oogenesis (PubMed:19906848, PubMed:23369713). Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation (PubMed:23369713).

7227:Dmel CG3578
gene id: 7227:Dmel_CG3578
uniprot id: E1JJD8
uniprot id: M9NE80
uniprot id: M9NEV8
uniprot id: M9PH16
uniprot id: Q24432
uniprot id: X2JI97
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Essential protein that may function as a transcription regulator. Vital for pupal development. Required for proper development of the optic lobes and wings, and abdominal pigmentation.
messages: In third-instar larvae, expressed in the brain region that will develop into optic lobes and more weakly in the thoracic part of the ventral ganglion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: The peak periods of expression are: mid-embryogenesis, the second day of pupal development and in the adult.

7227:Dmel CG7833
gene id: 7227:Dmel_CG7833
uniprot id: Q24169
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC5 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
messages: Nucleus
messages: ORC is composed of six subunits.

7227:Dmel CG8075
gene id: 7227:Dmel_CG8075
uniprot id: A0A0B4KEN4
uniprot id: A1Z7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG7849
gene id: 7227:Dmel_CG7849
uniprot id: Q29QN4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

7227:Dmel CG42324
gene id: 7227:Dmel_CG42324
uniprot id: M9PBL9
uniprot id: M9PE63
uniprot id: M9PEH1
uniprot id: M9PH72
uniprot id: Q9VZP0
uniprot id: Q9VZP1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9735
gene id: 7227:Dmel_CG9735
uniprot id: Q0KI98
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG17320
gene id: 7227:Dmel_CG17320
uniprot id: Q9VJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Mitochondrion
messages: Peroxisome

7227:Dmel CG6551
gene id: 7227:Dmel_CG6551
uniprot id: P23647
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Expressed both maternally and zygotically, low expression is present in males, larvae and pupae.
messages: Expressed in all imaginal disks, higher level in wing disk.
messages: Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2.

7227:Dmel CG12359
gene id: 7227:Dmel_CG12359
uniprot id: Q9VWK5
names: Similarity
messages: Belongs to the peptidase C48 family.

7227:Dmel CG12295
gene id: 7227:Dmel_CG12295
uniprot id: Q7K0H4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9195
gene id: 7227:Dmel_CG9195
uniprot id: Q9VXV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

7227:Dmel CG17228
gene id: 7227:Dmel_CG17228
uniprot id: A0A0B4K630
uniprot id: A0A0B4K6Q6
uniprot id: P29617
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Prospero homeodomain family.
messages: Cytoplasm
messages: Embryonic lethal, results in the aberrant expression of the homeobox genes ftz, eve and en in a subset of neuroblasts, and in axonal outgrowth and pathfinding defects in both motoneurons and sensory neurons.
messages: Homeodomain protein that controls neuronal identity (PubMed:1842358). As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd (PubMed:12429095, PubMed:15837198, PubMed:9380747). Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems (PubMed:20152183, PubMed:27510969, PubMed:1720353, PubMed:1842358, PubMed:1540176, PubMed:11051550, PubMed:18342578, PubMed:23056424, PubMed:16564014). Regulates asymmetric stem cell self-renewal together with brat (PubMed:16564014).
messages: In embryos, expressed mainly in neuronal precursors but detected also in cells lining the gut and Garland cells (at protein level) (PubMed:20152183, PubMed:27510969, PubMed:1720353, PubMed:1540176). Expressed during embryogenesis in different cells of the central and peripheral nervous system including neuroblasts and ganglion mother cells (GMC) (PubMed:1720353, PubMed:1842358).
messages: Nucleus
messages: The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
messages: cell cortex

7227:Dmel CG15078
gene id: 7227:Dmel_CG15078
uniprot id: A1ZBD6
uniprot id: Q7JZN2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds Ca(2+) via the C2 domains in absence of phospholipids.
messages: Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Motor neurons (at protein level).
messages: Mutant flies exhibit impaired homeostatic modulation of presynaptic neurotransmitter release and altered baseline neurotransmitter release transmission.

7227:Dmel CG4569
gene id: 7227:Dmel_CG4569
uniprot id: A0A0B4LHK2
uniprot id: Q27575
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Testis specific.
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG3264
gene id: 7227:Dmel_CG3264
uniprot id: Q9W273
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG7841
gene id: 7227:Dmel_CG7841
uniprot id: Q9VUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

7227:Dmel CG15145
gene id: 7227:Dmel_CG15145
uniprot id: Q9VJC3
names: Similarity
messages: Belongs to the CFAP91 family.

7227:Dmel CG31960
gene id: 7227:Dmel_CG31960
uniprot id: Q8IQ15
names: Function
names: Similarity
messages: Belongs to the calmodulin family.
messages: May be involved in calcium-mediated signal transduction.

7227:Dmel CG3262
gene id: 7227:Dmel_CG3262
uniprot id: Q9V9M8
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

7227:Dmel CG4686
gene id: 7227:Dmel_CG4686
uniprot id: Q9VDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

7227:Dmel CG3499
gene id: 7227:Dmel_CG3499
uniprot id: A0A0B4KFY4
uniprot id: F3YDF1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26160069). Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:31125351). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:26160069, PubMed:31125351). Required to control the accumulation of nonassembled respiratory chain subunits such as ND-30 (PubMed:26160069).
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion inner membrane
messages: Viable but lifespan is reduced and males are sterile. Mitochondrial proteostasis is disrupted leading to crista disorganization, mitochondrial unfolded protein stress and impaired complex I activity which increases levels of reactive oxygen species (ROS). These defects all likely contribute to the increase in Dronc-mediated apoptosis in neuromuscular tissue. The severity of the mitochondrial abnormalities and their resulting phenotypes increase with age, resulting in the progressive degeneration of photoreceptor neurons and locomotor activity and increased sensitivity to genetic and environmental stresses.

7227:Dmel CG17202
gene id: 7227:Dmel_CG17202
uniprot id: Q9VG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

7227:Dmel CG17584
gene id: 7227:Dmel_CG17584
uniprot id: Q9V6H2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG11086
gene id: 7227:Dmel_CG11086
uniprot id: A1Z6W5
names: Similarity
messages: Belongs to the GADD45 family.

7227:Dmel CG7012
gene id: 7227:Dmel_CG7012
uniprot id: A0A0B4KHG2
uniprot id: E1JIV8
uniprot id: Q7KS07
uniprot id: Q9VC27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
messages: Membrane

7227:Dmel CG3473
gene id: 7227:Dmel_CG3473
uniprot id: Q9VJS5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG14216
gene id: 7227:Dmel_CG14216
uniprot id: M9PHZ3
uniprot id: Q9VWE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

7227:Dmel CG4412
gene id: 7227:Dmel_CG4412
uniprot id: D1Z3A2
uniprot id: Q24407
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

7227:Dmel CG7496
gene id: 7227:Dmel_CG7496
uniprot id: Q9VS97
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Expressed from old embryos. Expressed in larvae and adults.
messages: In larvae, it is mainly expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.
messages: Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN.
messages: Secreted
messages: Strongly up-regulated by PGN from B.subtilis. Weakly or not expressed in normal conditions. Regulated by the imd/Relish pathway.

7227:Dmel CG8907
gene id: 7227:Dmel_CG8907
uniprot id: H9ZYQ1
uniprot id: Q95TJ6
names: Similarity
messages: Belongs to the EPS8 family.

7227:Dmel CG5808
gene id: 7227:Dmel_CG5808
uniprot id: Q9XYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG5450
gene id: 7227:Dmel_CG5450
uniprot id: M9NDC7
uniprot id: O96860
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a non-catalytic accessory component of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

7227:Dmel CG2246
gene id: 7227:Dmel_CG2246
uniprot id: A0A0B4JD23
uniprot id: A0A0B4JDE3
uniprot id: A0A0B4KHF5
uniprot id: A0A0B4KHJ3
uniprot id: A0A0B4KHW7
uniprot id: Q7KRU0
uniprot id: Q8IMI0
uniprot id: Q961V3
uniprot id: Q9VA53
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

7227:Dmel CG18530
gene id: 7227:Dmel_CG18530
uniprot id: Q9VG50
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG5440
gene id: 7227:Dmel_CG5440
uniprot id: Q9VQ00
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG2715
gene id: 7227:Dmel_CG2715
uniprot id: M9PIV2
uniprot id: Q7KVY7
uniprot id: S5W2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

7227:Dmel CG41624
gene id: 7227:Dmel_CG41624
uniprot id: A8Y592
names: Similarity
messages: Belongs to the cytochrome P450 family.

7227:Dmel CG5966
gene id: 7227:Dmel_CG5966
uniprot id: Q9W448
uniprot id: X2JDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG1989
gene id: 7227:Dmel_CG1989
uniprot id: D3DMZ2
uniprot id: Q8MSV1
uniprot id: Q9XZF0
names: Similarity
names: Subunit
messages: Belongs to the yippee family.
messages: Interacts with hemolin.

7227:Dmel CG31842
gene id: 7227:Dmel_CG31842
uniprot id: Q8IP62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

7227:Dmel CG1962
gene id: 7227:Dmel_CG1962
uniprot id: Q9VIK6
names: Similarity
messages: Belongs to the CDR2 family.

7227:Dmel CG2210
gene id: 7227:Dmel_CG2210
uniprot id: A0A0B4LHX6
uniprot id: A0A0B4LJ12
uniprot id: P08879
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homohexamer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
messages: Mutations cause abnormal tissue morphology and necrosis and widespread aberrant differentiation.
messages: cytoskeleton

7227:Dmel CG12113
gene id: 7227:Dmel_CG12113
uniprot id: Q9W3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 4 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Essential for development (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
messages: Nucleus

7227:Dmel CG32056
gene id: 7227:Dmel_CG32056
uniprot id: Q8IQD7
uniprot id: Q8IQD8
uniprot id: Q9VT88
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7227:Dmel CG16975
gene id: 7227:Dmel_CG16975
uniprot id: B7YZV6
uniprot id: M9PFS7
uniprot id: Q9VK33
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with pho as a component of the pho-repressive complex (PhoRC).
messages: MBT repeats have unique discriminatory binding activity for methylated Lys residues in H3 and H4; the MBT repeats bind mono- and dimethylated H3K9Me1, H3K9Me2, H4K20Me1 and H4K20Me2 but fail to interact with these residues if they are unmodified or trimethylated.
messages: Nucleus
messages: Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.

7227:Dmel CG9880
gene id: 7227:Dmel_CG9880
uniprot id: P81912
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 10-40 sensory cells in the third antenna segment and in the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG33839
gene id: 7227:Dmel_CG33839
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG7431
gene id: 7227:Dmel_CG7431
uniprot id: Q9VEG1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG8697
gene id: 7227:Dmel_CG8697
uniprot id: P07187
names: Function
messages: Component of the larval cuticle.

7227:Dmel CG15792
gene id: 7227:Dmel_CG15792
uniprot id: A0A0B4JD57
uniprot id: A0A0B4JD95
uniprot id: A0A0B4K7Q4
uniprot id: Q59E58
uniprot id: Q59E59
uniprot id: Q99323
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At germband retraction (stage 12), expression is high in the embryo amnioserosa and relatively low at the apical edge of the leading edge/ dorsalmost epidermal (DME) cells (PubMed:18816840, PubMed:23579691). Whereas at dorsal closure (stage 13), expression is relatively low in the amnioserosa and high in the DME cells (PubMed:18816840, PubMed:23579691). Isoforms containing exon 7 are detected in all stages of development and are expressed in embryos, early and late larvae, and adults (PubMed:8568878).
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: In Johnston's organ, expressed in neurons and scolopale cells.
messages: Interacts with sau (PubMed:24786584). Interacts with ck and Ubr3 (PubMed:27331610).
messages: Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis (PubMed:24786584). Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment (PubMed:27331610). Interaction with the myosin ck may be important for this function (PubMed:27331610).
messages: Ubiquitinated.
messages: cilium

7227:Dmel CG2867
gene id: 7227:Dmel_CG2867
uniprot id: A0A0B4K6L4
uniprot id: Q27601
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Involved in the first step (and regulatory point) of the de novo biosynthesis of purine nucleotides, where it catalyzes the transfer of glutamine amide to 5-phospho-alpha-D-ribose 1-diphosphate.
messages: Reduction in viability and frequent wing defects.

7227:Dmel CG2678
gene id: 7227:Dmel_CG2678
uniprot id: Q8T053
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

7227:Dmel CG43388
gene id: 7227:Dmel_CG43388
uniprot id: M9NEC7
uniprot id: M9NF11
uniprot id: M9NGY7
uniprot id: M9PE66
uniprot id: M9PGS8
uniprot id: M9PHI0
uniprot id: Q9W2W9
uniprot id: Q9W2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

7227:Dmel CG8166
gene id: 7227:Dmel_CG8166
uniprot id: A0A0B4LFH9
uniprot id: Q95TU8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylated on different cytoplasmic tyrosine residues.
messages: Prior to gastrulation, it is strongly expressed in the presumptive mesoderm. Mesodermal expression begins to fade during stages 13-14, persisting only in the cells that form the dorsal vessel. Expressed within the CNS from late stage 13, shortly after the first axons have extended. Detected in several dispersed clusters of cells within the CNS, increasing in number as development proceeds. Also expressed in the peripheral and exit glia, which migrate laterally out of the CNS between stages 14 and 17. Strongly expressed in motor axons that exit the CNS ipsilaterally via the segmental nerve root (SN). Not expressed on either commissural or longitudinal axons within the CNS, nor on motor axons that exit via the intersegmental nerve (ISN). In the periphery, it is detected on all branches of the SN. Also expressed at high level in exit and peripheral glia along both the SN and ISN.
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
messages: Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.

7227:Dmel CG6818
gene id: 7227:Dmel_CG6818
uniprot id: M9PI97
uniprot id: Q9VVW6
names: Similarity
messages: Belongs to the UPF0489 family.

7227:Dmel CG10742
gene id: 7227:Dmel_CG10742
uniprot id: Q9W4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG3943
gene id: 7227:Dmel_CG3943
uniprot id: O18391
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily.
messages: May have a role in detoxification and digestion during embryogenesis and larval development.
messages: Probably expressed both maternally and zygotically.
messages: Ubiquitously expressed before embryonic stage 11. At stage 11, expression is concentrated in the foregut and posterior midgut. By stage 15, in gastric caeca, pharynx, posterior spiracles and anterior edge of midgut. At the end of embryogenesis, expression is confined to gastric caeca. During third instar larvae, expressed at low levels in gastric caeca, midgut and hindgut and high level in fat body.

7227:Dmel CG10825
gene id: 7227:Dmel_CG10825
uniprot id: Q8SZZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ICE2 family.
messages: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
messages: Component of the little elongation complex (LEC), at least composed of Ell, Eaf, Ice1 and Ice2.
messages: Nucleus

7227:Dmel CG3157
gene id: 7227:Dmel_CG3157
uniprot id: P23257
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Interacts with Ote.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
messages: centrosome

7227:Dmel CG2302
gene id: 7227:Dmel_CG2302
uniprot id: Q9W3G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG6641
gene id: 7227:Dmel_CG6641
uniprot id: P54195
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in antenna, mostly on the medial and posterior surface of the third antennal segment.
messages: Secreted

7227:Dmel CG32479
gene id: 7227:Dmel_CG32479
uniprot id: M9PDK3
uniprot id: Q9W0L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG6888
gene id: 7227:Dmel_CG6888
uniprot id: Q9VUM4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

7227:Dmel CG18292
gene id: 7227:Dmel_CG18292
uniprot id: M9PEA2
uniprot id: Q9VZ27
names: Similarity
messages: Belongs to the CDK2AP family.

7227:Dmel CG4542
gene id: 7227:Dmel_CG4542
uniprot id: Q9W3V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Functions in developmental processes such as germband extension, the apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis prior to gastrulation (PubMed:24681004). Involved in the glycosylation and intracellular distribution of shg (E-cadherin) (PubMed:24681004). Function in cell intercalation in the lateral epidermis during germband extension may be due to its effect on shg (PubMed:24681004).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

7227:Dmel CG34031
gene id: 7227:Dmel_CG34031
uniprot id: M9NDG6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG18048
gene id: 7227:Dmel_CG18048
uniprot id: Q8SX24
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

7227:Dmel CG9160
gene id: 7227:Dmel_CG9160
uniprot id: A0A1B2AKC6
uniprot id: M9PDU4
uniprot id: Q94519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
messages: Complex I is composed of about 45 different subunits.
messages: Mitochondrion

7227:Dmel CG17934
gene id: 7227:Dmel_CG17934
uniprot id: Q01643
names: Developmental Stage
names: Domain
names: Similarity
names: Tissue Specificity
messages: Belongs to the MST(3)CGP family.
messages: Primary spermatocytes.
messages: Testis.
messages: This protein is mostly composed of repetitive C-G-P motifs.

7227:Dmel CG18347
gene id: 7227:Dmel_CG18347
uniprot id: Q9VGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG6963
gene id: 7227:Dmel_CG6963
uniprot id: A0A0B4K697
uniprot id: A0A0B4K7C4
uniprot id: A0A0B4KHL4
uniprot id: Q4AB31
uniprot id: Q59DW8
uniprot id: Q86BR9
uniprot id: Q86NK8
uniprot id: Q8IHB0
uniprot id: Q8INB6
uniprot id: Q9VEX2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

7227:Dmel CG8710
gene id: 7227:Dmel_CG8710
uniprot id: A1Z7A8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the coilin family.
messages: Cajal body
messages: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs (PubMed:19846657). Required for Cajal body formation (PubMed:19158395, PubMed:19846657).
messages: Cytoplasm
messages: In egg chambers expressed in the follicle cells, nurse cells and oocyte. Expressed in the larval brain, salivary glands, fat bodies and in the somatic hub cells at the tip of the testis. Expressed in the spermatogonia and spermatocytes, and in the adult ejaculatory duct (at protein level). Expressed in the adult Malpighian tubules.
messages: Nucleus
messages: Viable and fertile with no obvious phenotype (PubMed:19158395). Loss of Cajal bodies (CBs) in the nurse cells, spermatocytes, ejaculatory ducts (PubMed:19158395). Loss of CBs in the adult Malpighian tubule cells (PubMed:19158395, PubMed:19846657). Histone locus bodies (HLBs) in the same cell types are present and not affected (PubMed:19158395). In stage 8-9 oocytes, the single CB present in the germinal vesicle is unaffected (PubMed:19158395).
messages: centromere
messages: nucleoplasm
messages: spindle

7227:Dmel CG9969
gene id: 7227:Dmel_CG9969
uniprot id: E1JIA4
uniprot id: E5AJE7
uniprot id: Q9VZW8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or63a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butyl acetate, isoamyl acetate, and hexanoic acid.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG32448
gene id: 7227:Dmel_CG32448
uniprot id: Q8IPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

7227:Dmel CG3258
gene id: 7227:Dmel_CG3258
uniprot id: P09775
names: Function
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in the determination of the neuronal precursors of optic lobes in the central nervous system.
messages: L(1)SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe.

7227:Dmel CG4226
gene id: 7227:Dmel_CG4226
uniprot id: Q9VPV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG2168
gene id: 7227:Dmel_CG2168
uniprot id: P55830
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm
messages: Essential for oogenesis; required for late follicle cell development.
messages: Expressed both maternally and zygotically throughout all development.
messages: Flies exhibit disappearance of the follicular cells of the ovary and abnormalities of the associated germline derivatives, leading to failure of egg production.
messages: Produced by alternative splicing.
messages: Ubiquitously expressed in stage 8 embryos. During oogenesis, expression is located basally in somatic follicular epithelium and in the oocyte at the later stages.

7227:Dmel CG10119
gene id: 7227:Dmel_CG10119
uniprot id: Q03427
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Expressed in 12-22 hours embryos. Expression peaks in larvae and declines in pupae and adults.
messages: First detected from late stage 12 in the oenocytes, abdominal segments, hindgut and posterior spiracles, with expression increasing in stage 13 (PubMed:7593280) (at protein level). In stage 14, also becomes detectable in the foregut (PubMed:7593280) (at protein level). Stage 15 shows expression in the epidermis, dorsal longitudinal trunk, pharynx, esophagus and proventriculus, with the dorsal pharyngeal musculature showing expression in late stage 15 (PubMed:7593280) (at protein level). In stage 16 embryos, also detected in the exit glia with increasing expression in the somatic musculature (PubMed:7593280) (at protein level). Also detected in the visceral mesoderm but not in the midgut or central nervous system until the end of embryogenesis (PubMed:7593280) (at protein level). In third instar larvae, detectable at varying levels in all cell types (PubMed:7593280) (at protein level). Expressed in spermatocytes (at protein level) (PubMed:27402967).
messages: Interacts with MAN1.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis (PubMed:27402967).
messages: Nucleus
messages: Nucleus lamina

7227:Dmel CG31201
gene id: 7227:Dmel_CG31201
uniprot id: Q0KI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG6104
gene id: 7227:Dmel_CG6104
uniprot id: O97177
names: Developmental Stage
names: Function
messages: Expressed at the time when separation of neural and epidermal precursors cells occurs. Detected in the neuro-ectoderm of stage 9 embryos. At stage 10/11, accumulates at high levels in the presumptive mesoderm, however, it disappears quickly with the onset of germ band retraction. In eye disk, expression occurs close to, as well as posterior to the morphogenetic furrow. In the wing disk, found in the proneural clusters areas, the dorso-ventral boundary and vein/intervein regions.
messages: Part of the Notch signaling pathway.

7227:Dmel CG32335
gene id: 7227:Dmel_CG32335
uniprot id: Q8SXQ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

7227:Dmel CG7586
gene id: 7227:Dmel_CG7586
uniprot id: Q9VLT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11966
gene id: 7227:Dmel_CG11966
uniprot id: Q9VHJ6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Embryonic lethal. RNAi-mediated knockdown in the trachea of first instar larvae results in discontinuous tubes. RNAi-mediated knockdown in the tracheal terminal cells of first instar larva results in lumen devoid of taenidiae and occluded with disorganized electron-dense material, pan-tracheal liquid clearance defect as well as a breaks in the dorsal trunks.
messages: Expressed in embryo from stage 10 in all ectodermally-derived epithelia secreting cuticle. During germband retraction, epidermal expression is strongest in the T2, T3, and A8 epidermal parasegments, but not detected during primary branching. Pan-tracheal expression is first detected at stage 14 and continues during later stages coinciding with lumen growth and cuticle deposition. In addition to tracheal expression, expressed in epidermis, foregut, and hindgut.
messages: Nucleus
messages: Transcriptional activator. In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes.

7227:Dmel CG5904
gene id: 7227:Dmel_CG5904
uniprot id: Q9VUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

7227:Dmel CG2692
gene id: 7227:Dmel_CG2692
uniprot id: P09083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed in a segmentally repeating pattern to define the polarity of embryonic segments.
messages: Expressed in a single-segment repeat in the neurectoderm during germ-band extension and later in single neurons during neuronal differentiation.
messages: Nucleus

7227:Dmel CG2915
gene id: 7227:Dmel_CG2915
uniprot id: Q0E9F9
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG1487
gene id: 7227:Dmel_CG1487
uniprot id: Q9V393
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG18278
gene id: 7227:Dmel_CG18278
uniprot id: Q5BIL9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG31660
gene id: 7227:Dmel_CG31660
uniprot id: M9ND25
uniprot id: M9NDF0
uniprot id: M9PEK9
uniprot id: Q59E18
uniprot id: Q9VR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG1583
gene id: 7227:Dmel_CG1583
uniprot id: Q9W3I8
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG8801
gene id: 7227:Dmel_CG8801
uniprot id: A0A0B4LEY9
uniprot id: Q9V411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle (PubMed:24255106). May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs (PubMed:24255106). Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539, PubMed:35413237).
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

7227:Dmel CG9334
gene id: 7227:Dmel_CG9334
uniprot id: Q9VII7
uniprot id: X2JAJ8
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG32854
gene id: 7227:Dmel_CG32854
uniprot id: Q8I0J3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

7227:Dmel CG9092
gene id: 7227:Dmel_CG9092
uniprot id: M9PCA6
uniprot id: Q9VMJ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7227:Dmel CG34396
gene id: 7227:Dmel_CG34396
uniprot id: Q9W2L7
uniprot id: Q9W2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG3589
gene id: 7227:Dmel_CG3589
uniprot id: Q9W106
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

7227:Dmel CG13167
gene id: 7227:Dmel_CG13167
uniprot id: A1Z8V7
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

7227:Dmel CG17598
gene id: 7227:Dmel_CG17598
uniprot id: Q9VR62
names: Similarity
messages: Belongs to the PP2C family.

7227:Dmel CG7970
gene id: 7227:Dmel_CG7970
uniprot id: A0A0S0WGR0
uniprot id: Q9W0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG5247
gene id: 7227:Dmel_CG5247
uniprot id: L0CQ48
uniprot id: Q23976
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku70 family.
messages: Chromosome
messages: Expressed both maternally and zygotically, expression is at low levels in all stages of development.
messages: Heterodimer of a 70 kDa and a 80 kDa subunit.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats.

7227:Dmel CG7590
gene id: 7227:Dmel_CG7590
uniprot id: Q9VTH4
names: Developmental Stage
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DDIT4 family.
messages: Cytoplasm
messages: Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and by hypoxia in midgut and fat body.
messages: Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic developmental stages, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells.
messages: Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development.
messages: Intron retention.

7227:Dmel CG3340
gene id: 7227:Dmel_CG3340
uniprot id: P07247
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules.
messages: Nucleus

7227:Dmel CG3814
gene id: 7227:Dmel_CG3814
uniprot id: A0A0B4KEN6
uniprot id: Q6AWP0
uniprot id: Q8T8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7227:Dmel CG11253
gene id: 7227:Dmel_CG11253
uniprot id: Q9VU41
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZMYND10 family.
messages: Cytoplasm
messages: During embryogenesis expression is restricted to developing Ch neurons and absent from other ciliated sensory neurons. In the pupal antenna, expressed exclusively in the Ch neurons of Johnston's organ.
messages: Dynein axonemal particle
messages: Expression is dependent on the transcription factors that regulate motile cilia such as Rfx and Fd3F.
messages: Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility.
messages: Sensory defects and loss of the axonemal dynein arms. Flies display defective proprioception as a result of malfunctioning Ch neurons caused by inner and outer dynein arms (IDA and ODA, respectively) defects. Males sterility due to immotile sperm.
messages: Specifically expressed in cells with flagella and motile cilia: chordotonal sensory neurons and sperm.
messages: cilium

7227:Dmel CG17293
gene id: 7227:Dmel_CG17293
uniprot id: Q9VLN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 (PubMed:21694722, PubMed:21875999). Together with su(sable), part of a transcription termination checkpoint that promotes transcription termination of aberrant RNAs and their subsequent degradation by the nuclear exosome (PubMed:26577379).
messages: Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722, PubMed:21875999). Interacts with male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3 (PubMed:23295261). Interacts with su(sable) (PubMed:26577379).
messages: Nucleus

7227:Dmel CG17835
gene id: 7227:Dmel_CG17835
uniprot id: P05527
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the engrailed homeobox family.
messages: Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification. Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis. Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule.
messages: Expressed in row 6/7 of the embryonic neuroectoderm.
messages: Nucleus

7227:Dmel CG1514
gene id: 7227:Dmel_CG1514
uniprot id: Q9W3N0
names: Similarity
messages: Belongs to the sorting nexin family.

7227:Dmel CG1440
gene id: 7227:Dmel_CG1440
uniprot id: A8JV22
uniprot id: A8JV24
uniprot id: Q9W3F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

7227:Dmel CG31033
gene id: 7227:Dmel_CG31033
uniprot id: B7Z0R7
uniprot id: Q86BR6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

7227:Dmel CG4795
gene id: 7227:Dmel_CG4795
uniprot id: Q02910
names: Developmental Stage
names: Function
names: RNA Editing
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed early in photoreceptor cell development.
messages: Homodimer.
messages: Partially edited. Target of Adar.
messages: Plays important roles in both rhabdomere development and in photoreceptor cell survival. Might function as a calcium-sequestering 'sponge' to regulate the amount of free cytoplasmic calcium. It binds 0.3 mole of Ca(2+) per mole of protein.
messages: Soma and axons of photoreceptor cells of compound eyes and ocelli.

7227:Dmel CG33933
gene id: 7227:Dmel_CG33933
uniprot id: Q9VDQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity).
messages: Membrane

7227:Dmel CG31931
gene id: 7227:Dmel_CG31931
uniprot id: P84180
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Expressed in taste bristles in the foreleg and labial palps. In larvae, is expressed in neurons of the dorsal and posterior pharyngeal sense organs. Expressed in taste neurons that mediate sensitivity to bitter compounds.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds.

7227:Dmel CG2988
gene id: 7227:Dmel_CG2988
uniprot id: P18488
uniprot id: Q5BIB4
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a homeotic selector gene controlling antennal and mandibular segment identity.
messages: Belongs to the EMX homeobox family.
messages: EMS has two different spatial patterns of expression during embryogenesis. The EMS head-specific expression pattern initiates prior to cellular blastoderm and continues only until early germ-band extension. The EMS metameric expression pattern initiates after gastrulation and is expressed in the lateral neuroblasts, in ectodermal cells at the anterior lateral borders of each segment, and in the Filzkoerper primordia.
messages: Nucleus
messages: The sequence shown is that of strain canton S.

7227:Dmel CG1516
gene id: 7227:Dmel_CG1516
uniprot id: Q0E9E2
uniprot id: Q7KN97
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

7227:Dmel CG11771
gene id: 7227:Dmel_CG11771
uniprot id: Q9VC06
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

7227:Dmel CG12404
gene id: 7227:Dmel_CG12404
uniprot id: Q9VK46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG9386
gene id: 7227:Dmel_CG9386
uniprot id: Q9VHB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

7227:Dmel CG10440
gene id: 7227:Dmel_CG10440
uniprot id: D5SHR0
names: Disruption Phenotype
names: Function
names: Induction
messages: Functions with the transcription factor TfAP-2 to regulate octopamine neuronal signaling pathways that control behaviors such as male aggression, male mating, and the initiation of feeding (PubMed:30231996, PubMed:24142897, PubMed:25187989). Required for TfAP-2 transcriptional activity in octopaminergic neurons (PubMed:24142897, PubMed:25187989). Functions with TfAP-2 to regulate expression of genes which are involved in promoting octopamine production and secretion from octopaminergic neurons, such as Tbh and Vmat (PubMed:24142897, PubMed:25187989). Octopamine then modulates feeding and male aggression by regulating the expression of the satiation hormone Dsk in insulin-producing cells (IPCs) (PubMed:24142897, PubMed:25187989). Functions with octopamine and Dsk as part of a negative feedback loop to prevent overeating; acts with TfAP-2 to regulate octopamine signaling pathways that initiate feeding, then octopamine activates expression of Dsk which inhibits consummatory behavior (PubMed:25187989). May also be involved in negatively regulating nociception in larvae to prevent spontaneous pain and hyperalgesia (PubMed:30231996).
messages: RNAi-mediated knockdown in adult octopaminergic neurons, disrupts TfAP-2 expression resulting in behavioral abnormalities such as increased male aggression, reduced walking pace and overeating (PubMed:24142897, PubMed:25187989). Males display an increase in low-intensity fighting, with males performing more wing flicks and shoves during a 20 min fighting bout (PubMed:24142897). Males also display increased courtship behaviors, such as singing, circling and abdomen bends, towards males and virgin females (PubMed:24142897). Adults also eat significantly more over a 24 hr period and some overeat after starvation (PubMed:25187989). Inhibits expression of TfAP-2 in adults fed a normal diet, and inhibits the up-regulation of TfAP-2 in adults fed a low calorie diet or undergoing starvation (PubMed:25187989). Adults display decreased expression of the octopamine synthesis genes Tbh and Vmat, and the octopmaine signaling gene Dsk (PubMed:24142897). RNAi-mediated knockdown in class I, II, III, and IV md neurons, results in hypersensitive nociception behaviors, with larvae displaying reduced nocifensive escape locomotion (NEL) response latency to a 42 degrees Celsius heat probe (PubMed:30231996).
messages: Up-regulated in adults by starvation for 48 hours, whereas no up-regulation was detected at 24 hours.

7227:Dmel CG18859
gene id: 7227:Dmel_CG18859
uniprot id: Q9I816
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in ai2A olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the preference for citrus fruits for oviposition, especially through the response to valencene, the primary ligand of Or19a. Larvae growing on citrus fruits suffer a reduced risk of parasitism since endoparasitoid wasps that parasitize larvae are strongly repelled by the smell of citrus, as well as by valencene.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG2647
gene id: 7227:Dmel_CG2647
uniprot id: M9PGJ3
uniprot id: P07663
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
messages: Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).
messages: Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.
messages: Expression is sensitive to temperature but not to light.
messages: Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.
messages: Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).
messages: Nucleus
messages: Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.
messages: perinuclear region

7227:Dmel CG7529
gene id: 7227:Dmel_CG7529
uniprot id: Q9VP25
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG4539
gene id: 7227:Dmel_CG4539
uniprot id: Q9VL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

7227:Dmel CG7577
gene id: 7227:Dmel_CG7577
uniprot id: A0A0B4KHD5
uniprot id: A0A0B4KHV2
uniprot id: Q9VAJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG31116
gene id: 7227:Dmel_CG31116
uniprot id: H1UUP0
uniprot id: Q9VGH7
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At embryonic stages 13-16, expressed in a subset of the midline cells of the midline primordium and in all of the midline glia. Expressed along the Z-line of the sarcomere in larval longitudinal muscles.
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane
messages: Partially edited. Target of Adar.
messages: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.
messages: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

7227:Dmel CG9057
gene id: 7227:Dmel_CG9057
uniprot id: Q0KHS6
uniprot id: Q0KHS7
uniprot id: Q9VXY7
uniprot id: X2JKC1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the perilipin family.
messages: Cytoplasm
messages: Essential for embryogenesis. Required for normal deposition of neutral lipids in the oocyte.
messages: Expressed both maternally and zygotically. Expressed throughout development with highest zygotic expression in third instar larva and pupae.
messages: Lipid droplet
messages: Ubiquitous expression in early embryos. At stage 5 expression is restricted to the pole cells. At stage 11 expression is seen in the amnioserosa, refined to the fat body and midgut by stage 14. Also seen in the hindgut by the end of embryogenesis. Expression is seen in larval fat body (at protein level).

7227:Dmel CG1484
gene id: 7227:Dmel_CG1484
uniprot id: Q24020
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the villin/gelsolin family.
messages: Consists of a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction, and a C-terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding.
messages: Expressed both maternally and zygotically.
messages: Found in ovaries, larval fat bodies, brain and adult thorax.
messages: May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development.

7227:Dmel CG3606
gene id: 7227:Dmel_CG3606
uniprot id: M9PH94
uniprot id: Q27294
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Cabeza' means 'head' in Spanish.
messages: Belongs to the RRM TET family.
messages: Expressed in the developing embryo from the earliest stages of cellularization and is subsequently found in many cell types.
messages: May participate in a function common to the expression of most genes transcribed by RNA polymerase II.
messages: Nucleus
messages: Ubiquitous. Enriched in the brain and central nervous system during embryogenesis. Enriched in the adult head. Embryos contain both isoforms A and B, whereas later in development (heads and torsos) only isoform B is detected.

7227:Dmel CG17949
gene id: 7227:Dmel_CG17949
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG11184
gene id: 7227:Dmel_CG11184
uniprot id: Q9W1H3
names: Similarity
messages: Belongs to the RENT3 family.

7227:Dmel CG10850
gene id: 7227:Dmel_CG10850
uniprot id: Q9VZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

7227:Dmel CG2003
gene id: 7227:Dmel_CG2003
uniprot id: Q9V9S4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5602
gene id: 7227:Dmel_CG5602
uniprot id: Q9W1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Nucleus

7227:Dmel CG15719
gene id: 7227:Dmel_CG15719
uniprot id: Q9VYH6
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

7227:Dmel CG8470
gene id: 7227:Dmel_CG8470
uniprot id: Q9VXP3
names: Subcellular Location Annotation
messages: Mitochondrion

7227:Dmel CG6241
gene id: 7227:Dmel_CG6241
uniprot id: A0A0B4KG32
uniprot id: A0A0B4KH26
uniprot id: Q9VH20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

7227:Dmel CG41128
gene id: 7227:Dmel_CG41128
uniprot id: Q8SY69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG33336
gene id: 7227:Dmel_CG33336
uniprot id: A0A0B4K7P1
uniprot id: Q8IMZ4
uniprot id: Q9N6D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the p53 family.
messages: Nucleus

7227:Dmel CG14964
gene id: 7227:Dmel_CG14964
uniprot id: Q9VZT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG43089
gene id: 7227:Dmel_CG43089
uniprot id: M9ND39
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG2974
gene id: 7227:Dmel_CG2974
uniprot id: Q9W2Y3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

7227:Dmel CG3454
gene id: 7227:Dmel_CG3454
uniprot id: A0A0B4KEQ1
uniprot id: I0B8M2
uniprot id: Q05733
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.
messages: Localized primarily to the photoreceptors, in the eye.
messages: Required in photoreceptor transmitter synthesis (PubMed:8096176). Catlayzes the conversion of L-histidine to histamine (Probable).

7227:Dmel CG12031
gene id: 7227:Dmel_CG12031
uniprot id: Q9W0P8
uniprot id: T2GG71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which may include CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Component of the Mediator complex.
messages: Nucleus

7227:Dmel CG4726
gene id: 7227:Dmel_CG4726
uniprot id: Q9VPX2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1442
gene id: 7227:Dmel_CG1442
uniprot id: Q9VAR1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7227:Dmel CG8972
gene id: 7227:Dmel_CG8972
uniprot id: A1Z8R8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S54 family.
messages: Interacts with Pink1 and HtrA2.
messages: Lethal with most dying before pupation (PubMed:16713954). Mitochondria in the testis and skeletal muscles display morphological defects indicative of defective mitochondrial fusion (PubMed:16713954). The few escapers that survive to adulthood, display neurological defects, male sterility, and do not survive for longer than three days (PubMed:16713954). Also displays photoreceptor degeneration after prolonged light stimulation and abnormal photoreceptor synaptic function which specifically affects both the generation of light responses and the signal transfer across the first visual synapse (PubMed:16713954).
messages: Mitochondrial intramembrane protease which plays a critical role in the regulation of mitochondrial function (PubMed:16713954, PubMed:21945938). Essential for mitochondrial development and fusion during spermatogenesis and the development of neurons and muscles (PubMed:16713954, PubMed:21945938). Essential for proteolytic processing of Pink1 and HtrA2 into their mature forms (PubMed:19048081). May also be involved, but not required, for the proteolytic processing of Opa1 (PubMed:19048081, PubMed:21945938).
messages: Mitochondrion inner membrane

7227:Dmel CG15010
gene id: 7227:Dmel_CG15010
uniprot id: Q9VZF4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in follicle cell epithelium and imaginal disks, particularly in the morphogenetic furrow.
messages: Nucleus
messages: Part of a SCF E3 ubiquitin-protein ligase complex. Interacts with Myc and puf (PubMed:15182669, PubMed:24173801). Interacts with CycE (PubMed:11565033).
messages: RNAi-mediated knockdown in the posterior compartment of the larval wing disk increases cell size in the posterior compartment of the adult wing, resulting in an increase in the size of the posterior compartment as well as an increase in the ratio between the posterior and anterior areas.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively (PubMed:11565033, PubMed:15182669). Required for endocycles, but not mitosis in follicle cell epithelium (PubMed:15175253).

7227:Dmel CG32174
gene id: 7227:Dmel_CG32174
uniprot id: M9NDU8
uniprot id: Q9VVG6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7227:Dmel CG18627
gene id: 7227:Dmel_CG18627
uniprot id: Q9XZ68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

7227:Dmel CG9138
gene id: 7227:Dmel_CG9138
uniprot id: E1JHA6
uniprot id: Q9VM55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7227:Dmel CG9755
gene id: 7227:Dmel_CG9755
uniprot id: P25822
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Expressed both maternally and zygotically in embryos.
messages: Flies display defective abdomen pattern formation and are embryonic lethal.
messages: Interacts with nos and brat. Acts via the formation of a quaternary complex composed of pum, nos, brat and the 3'-UTR mRNA of hb.
messages: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:1459455, PubMed:1576962, PubMed:9404893, PubMed:9660969, PubMed:22345517). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:22345517). Mediates post-transcriptional silencing of E2f mRNA by binding to its 3'-UTR and promoting miRNA regulation (PubMed:22345517). Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole (PubMed:1459455, PubMed:1576962, PubMed:9404893, PubMed:9660969).
messages: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. Pum is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.

7227:Dmel CG5025
gene id: 7227:Dmel_CG5025
uniprot id: Q9VKY8
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Expressed both maternally and zygotically.
messages: First expressed in the midgut anlagen with subsequent expression in a variety of tissues including the gut and nervous system.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

7227:Dmel CG9038
gene id: 7227:Dmel_CG9038
uniprot id: Q9VXN1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10006
gene id: 7227:Dmel_CG10006
uniprot id: A4IJ72
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2204
gene id: 7227:Dmel_CG2204
uniprot id: P16378
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Expressed in the surface glial cells of the nerve cords at the larval stage (at protein level). Expressed throughout development.
messages: Expressed primarily in neuronal cell bodies in the brain, optic lobe, and thoracic and abdominal ganglia. Also expressed in antenna, oocytes and ovarian nurse cells.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.

7227:Dmel CG4625
gene id: 7227:Dmel_CG4625
uniprot id: A0A0B4KHK0
uniprot id: Q9VBQ6
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

7227:Dmel CG8715
gene id: 7227:Dmel_CG8715
uniprot id: Q86S05
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts in the nervous system to mediate the control of copulatory organs during courtship.
messages: At stage 11, expression is restricted to the neuroblasts, predominant in the central nervous system (CNS), including the brain and ventral nerve cord, and in the PNS. Later embryonic expression is seen in the gonads. Late third instar larvae show expression in the CNS, imaginal disks (including genital, eye-antennal, leg, wing and haltere disks), and gonads. In the larval brain, it is expressed in all of the glial cells and in clusters of neurons that projected contralaterally. In the larval ventral ganglion, it is expressed in subperineurial glia, peripheral exit glia, and a number of interneurons, but not in motor neurons. Isoform B is abundantly expressed in males and females. Isoform D is male specific and expressed at low levels.
messages: Cytoplasm
messages: Expressed both maternally and zygotically throughout development. Zygotic expression levels rise after embryonic stage 9.
messages: Male flies exhibit abnormal copulation. They fail to successfully withdraw their genitalia upon termination of copulation so end up 'stuck' to the female, tugging to separate. There is also a 'non-copulating' behavioral phenotype. There are no morphological defects in the male genitalia. Females can mate successfully but have reduced fertility. Complete loss of lig function results in lethality during early pupal stages.

7227:Dmel CG7892
gene id: 7227:Dmel_CG7892
uniprot id: Q8IQ91
uniprot id: Q8T030
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7227:Dmel CG8091
gene id: 7227:Dmel_CG8091
uniprot id: Q9XYF4
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C14A family.
messages: By ecdysone; exposure of salivary glands and midgut isolated from second instar larvae results in a massive increase in levels.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Interacts with Diap1; residues 114-125 interact with the second BIR domain of Diap1. Can form a stable complex with Drice. Rpr can out-compete Dronc for binding Diap1, therefore removing Diap1-mediated ubiquitination.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.
messages: The promiscuous caspase inhibitor p35 is neither cleaved by Dronc in vitro nor blocks Dronc activity in vivo.
messages: Ubiquitinated by Diap1, leading to its subsequent degradation.
messages: Ubiquitously expressed in embryos during early stages of development. In late third instar larvae, dramatic up-regulation in salivary glands and midgut before histolysis of these tissues.

7227:Dmel CG15643
gene id: 7227:Dmel_CG15643
uniprot id: Q9VXT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG1712
gene id: 7227:Dmel_CG1712
uniprot id: A0A0B4LEE5
uniprot id: Q0E9G8
uniprot id: Q9V4K2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons and in the adult head, abdomen, leg and wing. In larvae, is expressed in taste organs, as well as the brain and the gastrointestinal system.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7392
gene id: 7227:Dmel_CG7392
uniprot id: D3DML3
uniprot id: M9NEC0
uniprot id: M9PF42
uniprot id: Q9VLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

7227:Dmel CG6746
gene id: 7227:Dmel_CG6746
uniprot id: Q9VKD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG2050
gene id: 7227:Dmel_CG2050
uniprot id: P13469
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development. It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories.
messages: Nucleus
messages: The N-terminus is blocked.

7227:Dmel CG33981
gene id: 7227:Dmel_CG33981
uniprot id: A0A0B4KEY8
uniprot id: A1ZAZ9
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

7227:Dmel CG18473
gene id: 7227:Dmel_CG18473
uniprot id: Q9VHF2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

7227:Dmel CG4144
gene id: 7227:Dmel_CG4144
uniprot id: C6TP47
uniprot id: Q9VVR4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect beta-1,3-glucan binding protein family.
messages: Expressed at very low levels during embryonic development and at moderate levels in the larva, prepupal, pupal and adult stages.
messages: Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).
messages: Secreted

7227:Dmel CG5181
gene id: 7227:Dmel_CG5181
uniprot id: Q9VM17
names: Similarity
messages: Belongs to the SOSS-B family.

7227:Dmel CG17785
gene id: 7227:Dmel_CG17785
uniprot id: Q8SZ63
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May be involved in maintaining Golgi structure and in intra-Golgi transport.

7227:Dmel CG3856
gene id: 7227:Dmel_CG3856
uniprot id: A0A0B4KGF4
uniprot id: A0A0B4KGK1
uniprot id: A0A126GUW9
uniprot id: Q7JQF1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly enriched in mushroom body neuropil and in the ellipsoid body (at protein level) (PubMed:9570796). Expressed in oviduct epithelium (at protein level) (PubMed:19262750). Expressed in the adult and larval brain, thoracic and abdominal ganglia, terminal cells of the larval tracheal system, muscle, mature eggs and reproductive system (PubMed:14623240, PubMed:25743690).
messages: Isoform C: Barely detectable in adult body but is expressed in adult head and third instar larva. Isoform B: Detected in adult head, adult body, pupa, third instar larva, 0-4 hour embryo, 0-18 hour embryo and 17-19 hour embryo with lowest expression observed in adult body and 17-19 hour embryo.
messages: Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed:9570796, PubMed:15816867). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed:9570796, PubMed:15816867). Required for ovulation (PubMed:14623240, PubMed:19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed:26473732). Ligand binding probably also leads to activation of CamKII which is also required for ovulation (PubMed:19262750). Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness (PubMed:20223202). Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females (PubMed:23055498). Required in the mushroom body for appetitive olfactory learning (PubMed:23103875, PubMed:23345239). Specifically conveys the short-term reinforcing effects of sweet taste (PubMed:23103875, PubMed:25728694). In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3 (PubMed:24923784). Also plays a role in social behavior by modulating male agression (PubMed:24923784).
messages: Viable with no gross anatomical defects and females display normal courtship and copulation but are impaired in ovulation (PubMed:14623240). Many mature eggs are retained in the ovaries with mutant females laying significantly fewer eggs and taking much longer to ovulate an egg (PubMed:14623240, PubMed:26473732). Increased sleep with longer sleep bouts during the night and a greater number of sleep bouts during the day (PubMed:20223202). Severely impaired learning in appetitive olfactory conditioning which tests the capacity to learn and remember the odor associated with a sugar reward (PubMed:23345239).

7227:Dmel CG9889
gene id: 7227:Dmel_CG9889
uniprot id: Q9W1R1
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG4758
gene id: 7227:Dmel_CG4758
uniprot id: C6SV41
uniprot id: Q9VL49
uniprot id: Q9VL50
uniprot id: X2J9A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG3615
gene id: 7227:Dmel_CG3615
uniprot id: A0A0B4KF86
uniprot id: Q7JQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

7227:Dmel CG7832
gene id: 7227:Dmel_CG7832
uniprot id: Q9VFH4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG14792
gene id: 7227:Dmel_CG14792
uniprot id: P38979
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with oho23B/rpS21.
messages: Cytoplasm
messages: Expressed both maternally and zygotically in embryos.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development.
messages: Was originally thought to be a laminin receptor.

7227:Dmel CG33829
gene id: 7227:Dmel_CG33829
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG4561
gene id: 7227:Dmel_CG4561
uniprot id: Q9VV60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

7227:Dmel CG3382
gene id: 7227:Dmel_CG3382
uniprot id: Q9W270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane

7227:Dmel CG11453
gene id: 7227:Dmel_CG11453
uniprot id: Q9VDU0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG9293
gene id: 7227:Dmel_CG9293
uniprot id: Q9VJY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Chromosome
messages: Component of the Enok complex composed of at least Br140, enok, Eaf6 and Ing5.
messages: Component of the Enok complex which has a histone H3 acetyltransferase activity.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7227:Dmel CG17198
gene id: 7227:Dmel_CG17198
uniprot id: Q9VBM8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG14992
gene id: 7227:Dmel_CG14992
uniprot id: Q9VZI2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm
messages: Detected in ovaries (at protein level) (PubMed:25223282). In adults, relatively higher expression in the head compared to the body (PubMed:11997505).
messages: In stage 13 embryos at the beginning of dorsal closure, enriched in the leading edge of the epidermis (at protein level).
messages: Interacts with yki and ex (PubMed:27462444). Interacts with drk (PubMed:22615583). Likely to be a member of an axonal guidance receptor complex that includes SH3PX1, dock and Dscam (PubMed:11773052). Interacts (via N-terminus) with dock (PubMed:23562806, PubMed:11773052). Interacts with SH3PX1 (via SH3 domain) (PubMed:11773052).
messages: No visible developmental defects but males and females display reduced fertility (PubMed:27462444, PubMed:22615583, PubMed:23562806). Males are sterile due to disruption of spermatid coiling (PubMed:27462444, PubMed:22615583, PubMed:23562806). Spermatids individualization complexes are displaced from the outer region of the testis coil to the inner region and display increased apoptosis (PubMed:22615583). During oogenesis, defective assembly and disassembly of cytoophidium in nurse cells result in a range of phenotypes resulting from reduced CTP production (PubMed:25223282). These include reduced egg laying, disruptions in the plasma membrane between adjacent nurse cells that result in the nurse cells fusing, and reduced nurse cell nuclei diameter most likely as a result of defective endoreplication (PubMed:25223282). Cytoophidium are observed in the germanium at an earlier developmental stage and persist inappropriately into late-stage egg chambers (PubMed:25223282). The number of cytoophidium in the cytoplasm of nurse cells is increased and their length is reduced (PubMed:25223282). Enhances the small eye phenotype in hid mutants (PubMed:22615583). Developing embryos display a very low frequently of dorsal defects (PubMed:18816840). Simultaneous knockdown of Ack and Ack-like results in many embryos failing to properly secrete the cuticle likely due to the loss of zip expression (PubMed:18816840). Mutants also display defects in the dorsal surface including holes in the cuticle and germband retraction failure (PubMed:18816840).
messages: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in diverse biological functions such as cell survival, cell differentiation, cell growth and proliferation (PubMed:11997505, PubMed:18816840, PubMed:22615583, PubMed:23562806, PubMed:25223282, PubMed:27462444). Phosphorylates SH3PX1 and ex (PubMed:22615583, PubMed:11773052, PubMed:27462444). Phosphorylates SH3PX1 predominantly on 'Tyr-56', which likely promotes the recruitment of SH3PX1 to an axonal guidance receptor complex that includes dock and Dscam; because phosphorylation of SH3PX1 increases its interaction with the complex member dock while decreasing its interaction with the actin cytoskeleton modulator WASp (PubMed:11773052). In the wing and eye, promotes tissue growth, and during embryogenesis coordinates cell shape changes required for correct dorsal closure (PubMed:22615583, PubMed:27462444, PubMed:18816840). Functions in the negative regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway by enhancing yki activity thereby promoting cell proliferation and inhibiting apoptosis (PubMed:22615583, PubMed:27462444). This is accomplished, at least in part, by phosphorylating ex thereby reducing its ability to efficiently activate the Hippo signaling cascade (PubMed:27462444). In the eye disk, wing disk and possibly spermatids, inhibits programmed cell death induced by hid and rpr through a mechanism that is independent of the MAP kinase signal transduction pathway (PubMed:22615583). Essential for male and female fertility (PubMed:22615583, PubMed:23562806). During oogenesis required for the correct temporal assembly, and consequently the catalytic activity of long CTPsyn filaments (cytoophidium) in the germline nurse cells, likely by phosphorylating an unidentified substrate that is essential for linking individual CTPsyn filaments into large, catalytically active assemblies (PubMed:25223282).
messages: Phosphorylated (PubMed:22615583). Autophosphorylated (PubMed:11773052).
messages: The SAM and SH3 domains are required for localization to clathrin-coated vesicles in spermatocytes.
messages: The SAM, Protein kinase and SH3 domains are required for sperm formation.
messages: clathrin-coated vesicle

7227:Dmel CG14120
gene id: 7227:Dmel_CG14120
uniprot id: Q9VU22
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7227:Dmel CG7033
gene id: 7227:Dmel_CG7033
uniprot id: Q9W392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7227:Dmel CG3747
gene id: 7227:Dmel_CG3747
uniprot id: O77062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7227:Dmel CG6871
gene id: 7227:Dmel_CG6871
uniprot id: P17336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Homotetramer.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

7227:Dmel CG12128
gene id: 7227:Dmel_CG12128
uniprot id: A1Z830
uniprot id: A1Z831
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

7227:Dmel CG4454
gene id: 7227:Dmel_CG4454
uniprot id: Q9VLD6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the borealin family.
messages: Component of the CPC complex.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of embryonic mitosis. The CPC complex has essential functions at the centromere for ensuring sister chromatid cohesion, recruitment of the CPC to kinetochores, and chromosome alignment and segregation. There is no function in meiotic histone phosphorylation or spindle formation.
messages: Flies show multiple mitotic defects, including multipolar spindles that result in large polyploid cells and often in delayed apoptosis. The developmental consequences of these defects include cell-autonomous and non-autonomous defects in cell-type specification and tissue architecture. Flies also display a drastic decrease in histone H3 'Ser-10' phosphorylation, suggesting that the CPC complex mediates phosphorylation of 'Ser-10' of histone H3.
messages: Nucleus
messages: Ubiquitously expressed in the early embryo. Expression is restricted to the ventral nerve cord and brain during later embryonic stages.
messages: centromere
messages: spindle

7227:Dmel CG7359
gene id: 7227:Dmel_CG7359
uniprot id: M9PGI6
uniprot id: O77434
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

7227:Dmel CG11859
gene id: 7227:Dmel_CG11859
uniprot id: Q9VBU2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

7227:Dmel CG17265
gene id: 7227:Dmel_CG17265
uniprot id: Q9VQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

7227:Dmel CG3874
gene id: 7227:Dmel_CG3874
uniprot id: B7Z066
uniprot id: Q95YI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Golgi apparatus membrane
messages: Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen.
messages: Membrane

7227:Dmel CG10222
gene id: 7227:Dmel_CG10222
uniprot id: Q9VU67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

7227:Dmel CG10803
gene id: 7227:Dmel_CG10803
uniprot id: M9PDP5
uniprot id: M9PGK9
uniprot id: Q9W4R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

7227:Dmel CG1637
gene id: 7227:Dmel_CG1637
uniprot id: Q9VZ56
uniprot id: Q9VZ57
uniprot id: Q9VZ58
uniprot id: X2JB52
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

7227:Dmel CG14744
gene id: 7227:Dmel_CG14744
uniprot id: A0A0B4LEG9
uniprot id: A0A0B4LEV7
uniprot id: A1Z7I1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9492
gene id: 7227:Dmel_CG9492
uniprot id: A0A0B4K614
uniprot id: A0A0B4K648
uniprot id: A0A0B4LH20
uniprot id: Q9VH97
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG7241
gene id: 7227:Dmel_CG7241
uniprot id: Q9VG17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG34401
gene id: 7227:Dmel_CG34401
uniprot id: Q9VWN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ZSWIM8 family.
messages: Component of the SCF-like E3 ubiquitin-protein ligase complex.
messages: Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO1, thereby exposing miRNAs for degradation (By similarity).

7227:Dmel CG32547
gene id: 7227:Dmel_CG32547
uniprot id: Q59E37
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG6846
gene id: 7227:Dmel_CG6846
uniprot id: Q9VVU2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

7227:Dmel CG2677
gene id: 7227:Dmel_CG2677
uniprot id: O76863
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

7227:Dmel CG3845
gene id: 7227:Dmel_CG3845
uniprot id: A1Z968
uniprot id: Q0E996
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7227:Dmel CG5149
gene id: 7227:Dmel_CG5149
uniprot id: Q9VM22
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2086
gene id: 7227:Dmel_CG2086
uniprot id: M9PBI3
uniprot id: M9PDW5
uniprot id: M9PGU6
uniprot id: Q9W0A0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MEGF family.
messages: By axon injury which results in up-regulation on severed axons with levels reaching a peak between 12 and 24 hours after injury (at protein level) (PubMed:16772169). By ecdysone (PubMed:16772168).
messages: Cell membrane
messages: Cytoplasm
messages: Dephosphorylated by csw which is required for the inhibition of glial cell engulfment of axonal debris produced following axonal injury.
messages: Embryos show no defects in early central nervous system (CNS) development but display defective CNS cell corpse engulfment (PubMed:12765609). Increased number and volume of apoptotic particles in the nerve cord (PubMed:18455990). Suppression of glial engulfment of larval axons which results in defective axon pruning with most larval axons remaining in the mushroom body dorsal lobe at 18 hours after puparium formation in contrast to the wild-type where most of the larval axons are pruned by this time (PubMed:16772168, PubMed:16772170). Failure of glia to respond to axon injury, resulting in severed axons not being cleared from the CNS (PubMed:16772169). Impaired clearance of degenerating dendrites (PubMed:24412417). Highly abnormal neuromuscular junctions characterized by reduced synaptic growth, the accumulation of presynaptic debris and pruned ghost boutons, and reduced larval mobility (PubMed:19707574). Significant defects in germ cell engulfment by follicle cells (PubMed:22992958). Defective larval salivary gland death with persistance of salivary gland material in 98% of mutants 24 hours after puparium formation (PubMed:20577216). Reduced hemocyte phagocytosis of S.aureus following infection with infected flies dying earlier than controls (PubMed:19890048). Following wounding, impaired migration of macrophages to wound sites (PubMed:26028435). Reduced lifespan.(PubMed:25111228,Ref.27) Reduced climbing performance and impaired motor function with mutants displaying abnormal positioning of the legs and a rapid age-dependent decline in locomotor activity from 3 days to 7-10 days of adult life (PubMed:25111228). In 30-40 day old flies, pathological changes in thoracic skeletal muscle, such as loss of striation, variability in fiber size and vacuolization, that mainly affect the tergal depressor of the trochanter.(PubMed:25111228) Marked degeneration and vacuolization of the nervous system including brain and thoracic ventral ganglia, and degeneration of the retina a…
messages: Expressed in adult head (at protein level) (PubMed:22426252). Expressed in glia, macrophages and ectoderm (at protein level) (PubMed:18455990). Detected in glia around the mushroom body dorsal lobe and in glial processes infiltrating the medial lobe (at protein level) (PubMed:16772168). Expressed in adult brain glia including antennal lobe glia (at protein level) (PubMed:16772169). Expressed in the larval fat body (at protein level) (PubMed:20577216). Expressed in the ovary (at protein level) (PubMed:22992958). Isoform B: Predominant isoform in adult glia (PubMed:22426252).
messages: In glial cells around the mushroom body dorsal lobe, expression is weak in wandering larvae and pupae at 12 hours after puparium formation (APF) and is elevated in pupae at 6 hours APF (PubMed:16772168). In naive stage 11 macrophages, expressed at low levels with increased levels seen following apoptotic cell corpse uptake and a further increase observed by stage 15 (PubMed:27212238). Isoform A: Selectively expressed in adults (PubMed:22426252).
messages: Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168).
messages: Interacts with csw; this results in dephosphorylation of drpr isoform A which is required for the inhibition of glial cell engulfment of axonal debris produced following axonal injury (PubMed:22426252).
messages: Isoform B: The intracellular domain is required for glial engulfment activity. Isoform A: The intracellular domain contains an 11-residue insertion compared to isoform B and is incapable of promoting glial engulfment.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated on tyrosine residues (PubMed:18432193, PubMed:19927123, PubMed:23337816, PubMed:23420848). Phosphorylation is induced by binding to prtp (PubMed:19927123). It is also induced by binding to the membrane phospholipid phosphatidylserine (PubMed:23420848). Phosphorylation may be mediated directly or indirectly by Src42a and is required for interaction with shark (PubMed:18432193).
messages: Postsynaptic cell membrane
messages: Potently inhibits glial cell engulfment of axonal debris produced following axonal injury.
messages: Promotes engulfment of axonal debris by glial cells following axonal injury.
messages: Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (PubMed:15342648, PubMed:16772168, PubMed:16772169, PubMed:18984163, PubMed:20577216, PubMed:22992958, PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (PubMed:19927123, PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (PubMed:16772168, PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (PubMed:16772169, PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (PubMed:22992958, PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (PubMed:20577216). Also involved in bacterial phagocytosis (PubMed:18984163). Required for hemocyte phagocyto…
messages: axon
messages: cell cortex
messages: phagocytic cup
messages: phagosome

7227:Dmel CG6549
gene id: 7227:Dmel_CG6549
uniprot id: Q9VJD3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG5 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Expressed in embryos, and adult males and females.
messages: Golgi apparatus membrane
messages: Males are sterile.
messages: Required for normal Golgi function and necessary during spermatogenesis. Required for cleavage furrow ingression during cytokinesis in dividing spermatocytes and for the extensive polarized cell growth that accompanies spermatid elongation.

7227:Dmel CG11518
gene id: 7227:Dmel_CG11518
uniprot id: Q9V9W8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear ARM/PAN complex.
messages: Expressed both maternally and zygotically throughout development.
messages: Involved in signal transduction through the Wnt pathway.
messages: Nucleus
messages: Ubiquitous throughout embryogenesis and larval development.

7227:Dmel CG2227
gene id: 7227:Dmel_CG2227
uniprot id: P36951
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

7227:Dmel CG7100
gene id: 7227:Dmel_CG7100
uniprot id: O15943
uniprot id: Q4ABE7
uniprot id: Q4ABE8
uniprot id: Q4ABE9
uniprot id: Q4ABF0
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
messages: Cell membrane
messages: In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

7227:Dmel CG10130
gene id: 7227:Dmel_CG10130
uniprot id: Q7JZN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

7227:Dmel CG31693
gene id: 7227:Dmel_CG31693
uniprot id: Q2PDP2
uniprot id: Q7KRS1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5359
gene id: 7227:Dmel_CG5359
uniprot id: Q9VH45
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7227:Dmel CG14049
gene id: 7227:Dmel_CG14049
uniprot id: Q9W4Z4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed at a low level in the larval gut.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

7227:Dmel CG9773
gene id: 7227:Dmel_CG9773
uniprot id: Q9VHN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Golgi apparatus membrane
messages: Required for cell surface expression of acetylcholine receptors.

7227:Dmel CG10125
gene id: 7227:Dmel_CG10125
uniprot id: M9PEB8
uniprot id: Q9VRX6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed both maternally and zygotically. First seen at the embryonic syncytial blastoderm stage.
messages: Expressed in nurse cells and oocyte during oogenesis. Uniform expression in imaginal wing disk and low expression in developing imaginal CNS. Expressed in embryonic pole cells and primordial germ cells.
messages: Membrane
messages: Structural component of the gap junctions in germline cells. Required for differentiation and survival of germline cysts in females and of spermatogonia in males; gap junctional communication between spermatogonia and somatic cyst cells may be required for normal differentiation and survival of spermatogonia.
messages: Structural component of the gap junctions.
messages: gap junction

7227:Dmel CG31728
gene id: 7227:Dmel_CG31728
uniprot id: Q9VK10
names: Similarity
messages: Belongs to the peptidase S1 family. CLIP subfamily.

7227:Dmel CG7852
gene id: 7227:Dmel_CG7852
uniprot id: Q9W0E1
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17795
gene id: 7227:Dmel_CG17795
uniprot id: Q9VRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG2028
gene id: 7227:Dmel_CG2028
uniprot id: E1JJI5
uniprot id: P54367
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity increases following DNA damage.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling (PubMed:22095083). Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling (PubMed:11955436, PubMed:11927557, PubMed:22095083). Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh (PubMed:15616566). Together with dco, regulates proteolytic processing of ci by phosphorylating it, which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing (PubMed:16326393). Inhibits condensin II interphase activity by promoting degradation of the Cap-H2 regulatory subunit and limiting the levels of chromatin-bound Cap-H2 which regulates interphase chromosome organization (PubMed:25723539).
messages: Cytoplasm
messages: Expressed during early embryogenesis and in adult females (at protein level).
messages: Interacts with cos.
messages: Nucleus
messages: Phosphorylated. The dephosphorylated kinase is active in the cytoplasm while the active kinase in the nucleus is phosphorylated.

7227:Dmel CG32490
gene id: 7227:Dmel_CG32490
uniprot id: A0A0B4KG19
uniprot id: A0A1B2AKT6
uniprot id: E1JJ32
uniprot id: E1JJ33
uniprot id: E1JJ35
uniprot id: E1JJ37
uniprot id: E8NH35
uniprot id: Q8IPM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complexin/synaphin family.
messages: Binds to the SNARE core complex containing Snap25, synaptobrevin and Syx1A.
messages: Membrane
messages: Positively regulates a late step in synaptic vesicle exocytosis.

7227:Dmel CG9033
gene id: 7227:Dmel_CG9033
uniprot id: A1Z8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG2072
gene id: 7227:Dmel_CG2072
uniprot id: Q7KND8
names: Similarity
messages: Belongs to the MAD1 family.

7227:Dmel CG2257
gene id: 7227:Dmel_CG2257
uniprot id: Q7JW03
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7227:Dmel CG32732
gene id: 7227:Dmel_CG32732
uniprot id: Q9W3U1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: No visible phenotype (PubMed:30067821). Cells show complete loss of actin histidine methylation (PubMed:30526847).
messages: Nucleus
messages: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-74'.

7227:Dmel CG14946
gene id: 7227:Dmel_CG14946
uniprot id: Q9VKB8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG9540
gene id: 7227:Dmel_CG9540
uniprot id: Q9VY19
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG31495
gene id: 7227:Dmel_CG31495
uniprot id: Q8ING5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

7227:Dmel CG33548
gene id: 7227:Dmel_CG33548
uniprot id: O46040
uniprot id: P83501
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.

7227:Dmel CG11218
gene id: 7227:Dmel_CG11218
uniprot id: Q8SY61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PBP/GOBP family.
messages: Exclusively or primarily restricted to the olfactory system. Expressed in all olfactory sensilla including antenna, maxillary palp, proboscis, other adult chemosensory and larval chemosensory organ. Also expressed in the wing and tarsal gustatory sensilla and dorsal organ. Expressed in larval hemolymph.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
messages: Secreted

7227:Dmel CG7848
gene id: 7227:Dmel_CG7848
uniprot id: Q7K3R0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

7227:Dmel CG9621
gene id: 7227:Dmel_CG9621
uniprot id: Q9VFS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7227:Dmel CG9504
gene id: 7227:Dmel_CG9504
uniprot id: Q9VY01
names: Developmental Stage
names: Function
names: Induction
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Highly expressed in the late stage of the last instar larval stage and the pre-pupal stage (PubMed:15813704). Detected at 4h into the last larval instar; however, expression levels are low during the feeding stage (PubMed:15813704). Levels increase from 16 h, reach a peak at 48h, quickly decrease just before puparium formation, and rise again after pupariation (PubMed:15813704). Highly expressed in midgut in the third instar larvae (PubMed:15813704).
messages: Induced by RH-0345, which is an ecdysone agonist used as insecticide.
messages: Involved in the inactivation of ecdysteroid molting hormones by converting ecdysteroids into 3-dehydroecdysteroids.

7227:Dmel CG32679
gene id: 7227:Dmel_CG32679
uniprot id: Q8IRL3
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG7878
gene id: 7227:Dmel_CG7878
uniprot id: Q7K4L8
names: Similarity
messages: Belongs to the DEAD box helicase family.

7227:Dmel CG9699
gene id: 7227:Dmel_CG9699
uniprot id: Q0KHR7
uniprot id: Q7KUX3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7227:Dmel CG7911
gene id: 7227:Dmel_CG7911
uniprot id: Q9VAC4
names: Similarity
messages: Belongs to the nucleoplasmin family.

7227:Dmel CG9825
gene id: 7227:Dmel_CG9825
uniprot id: Q9W1Z1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10281
gene id: 7227:Dmel_CG10281
uniprot id: Q05913
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIF alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Nucleus
messages: Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

7227:Dmel CG10159
gene id: 7227:Dmel_CG10159
uniprot id: Q7JN06
uniprot id: Q94513
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8850
gene id: 7227:Dmel_CG8850
uniprot id: A1Z8V9
uniprot id: A1Z8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG6463
gene id: 7227:Dmel_CG6463
uniprot id: Q9VTB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7227:Dmel CG8484
gene id: 7227:Dmel_CG8484
uniprot id: Q9VH70
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in testis; primary spermatocytes.
messages: Interacts with comr.
messages: Nucleus
messages: Required for male meiotic division and spermatid differentiation. Required for accumulation of aly and comr on chromatin. May function as a transcription factor.

7227:Dmel CG1078
gene id: 7227:Dmel_CG1078
uniprot id: Q9VN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

7227:Dmel CG3665
gene id: 7227:Dmel_CG3665
uniprot id: P34082
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: GPI-anchored form.
messages: In embryos, both isoforms are initially expressed on the surface of the axons in the MP1 pathway and later on several other longitudinal axon fascicles.
messages: Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

7227:Dmel CG31368
gene id: 7227:Dmel_CG31368
uniprot id: Q7KSN8
uniprot id: Q9VGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWF11 family.
messages: Nucleus

7227:Dmel CG30181
gene id: 7227:Dmel_CG30181
uniprot id: Q8MLR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG16724
gene id: 7227:Dmel_CG16724
uniprot id: P11596
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males.
messages: Nucleus speckle
messages: RS domain directs localization of proteins to the speckled subnuclear compartment and the purpose of this localization is to allow colocalization and co-concentration of components of the splicing and splicing regulatory machinery to permit relatively high rates and/or efficiencies of reaction and interaction.
messages: The sexual regulation of tra occurs through a mechanism of sex-specific alternative RNA splicing. The non-sex-specific RNA expressed in males is not translated.

7227:Dmel CG7471
gene id: 7227:Dmel_CG7471
uniprot id: Q94517
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:11571273, PubMed:28245922, PubMed:12408863). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:11571273, PubMed:8955276, PubMed:15545624, PubMed:15306652). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed:11571273). Involved in position-effect variegation (PEV) (PubMed:11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed:28245922).
messages: Component of a form of the Esc/E(z) complex present specifically during early embryogenesis which is composed of Caf1-55, esc, E(z), Su(z)12, Pcl and HDAC1 (PubMed:12533794, PubMed:12408863, PubMed:12697833). The Esc/E(z) complex may also associate with Pcl and HDAC1 during early embryogenesis (PubMed:12697833). This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2 (PubMed:12533794). The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (PubMed:12533794). Interacts with the histone methyltransferase Su(var)3-9 (PubMed:11571273). Component of a complex that contains at least HDAC1, CoRest and Su(var)3-3/Hdm (PubMed:15306652). Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, HDAC1 and l(3)mbt (PubMed:15545624). Interacts with the chromatin-remodeler Mi-2 (PubMed:18250149).
messages: Nucleus
messages: RNAi-mediated knockdown results in loss of type II neuroblasts.

7227:Dmel CG9062
gene id: 7227:Dmel_CG9062
uniprot id: A0A0B4KET0
uniprot id: Q1LZ08
names: Function
names: Similarity
messages: Belongs to the WD repeat WDR48 family.
messages: Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity).
messages: Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.

7227:Dmel CG5994
gene id: 7227:Dmel_CG5994
uniprot id: P92204
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Component of the NELF complex, which is at least composed of TH1/Nelf-D and Nelf-E.
messages: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.
messages: Nucleus

7227:Dmel CG9750
gene id: 7227:Dmel_CG9750
uniprot id: M9PFN1
uniprot id: Q9V3K3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth.
messages: Belongs to the RuvB family.
messages: Death at first larval instar.
messages: Expressed both maternally and zygotically.
messages: Forms homohexameric rings. May form a dodecamer with rept made of two stacked hexameric rings (By similarity). Component of the chromatin remodeling Ino80 complex. Interacts with Myc and pont.
messages: Higher expression occurs in primordia of mesoderm, anterior and posterior midgut and cephalic furrow early in gastrulation, as well as in endoderm and mesoderm lineages during germ band extension. Later in development expression is only maintained in endoderm cells. Expressed in thoracic and abdominal segment neural precursors of all embryonic chordotonal organs.
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

7227:Dmel CG31103
gene id: 7227:Dmel_CG31103
uniprot id: Q9VBV9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11205
gene id: 7227:Dmel_CG11205
uniprot id: A1Z757
uniprot id: Q7JY97
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

7227:Dmel CG9761
gene id: 7227:Dmel_CG9761
uniprot id: A0A0B4K692
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Detected in the stellate cells in the main segment and the bar-shaped cells in the initial segment of male and female Malpighian tubules (at protein level) (PubMed:15554877). Expressed in the spermatheca (at protein level) (PubMed:24395329). Expressed in the somatic cyst cells of the testes, with increased expression at the tail end of elongating cysts (PubMed:15554877, PubMed:24395329). Expressed in the ovaries with strong expression in the posterior polar cells and in border cells of stage 8, 9, and 10 follicles (PubMed:24395329). In adults and third-instar larvae, expressed in the brain, ventral ganglion, and stellate cells (PubMed:24395329). Also expressed in the foregut and the imaginal disks (eye, antennal and leg) of third-instar larvae (PubMed:24395329). In stage 17 embryos, expressed in the tracheal system, foregut, hindgut and epidermis (PubMed:24395329). Also expressed in the stellate cell progenitors of the caudal visceral mesoderm in embryos (PubMed:17157960).
messages: Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706).
messages: N-glycosylated.
messages: RNAi-mediated knockdown in females mated to wild-type males results in laying of fewer eggs due to impaired sperm retention and increased sperm displacement by rival ejaculates (PubMed:24395329). Females also show a reduced hatch rate and only 20% of their progeny reach the adult stage (PubMed:24395329). Unhatched eggs are fertilized but contain a clear polar body rosette instead of an embryo, suggesting that the eggs activate and complete meiosis but then embryogenesis is arrested (PubMed:24395329). Wild-type females mated to males that undergo RNAi-mediated knockdown, display a slight reduction in fertility but lay the same number of eggs and have the same hatch rate as those mated to wild-type males (PubMed:24395329). RNAi-mediated knockdown in the dorsal paired medial neurons impairs middle-term memory (MTM), but has no effect on long-term memory (LTM) formation, normal aversion learning and anesthesia-resistant memory (ARM) (PubMed:27629706). RNAi-mediated knockdown in all mushroom body neurons has no effect on learning, ARM and LTM (PubMed:27629706). However, simultaneous knockdown with Nep3 does impair LTM, and simultaneous knockdown with both Nep3 and Nep4 results in a further reduction in LTM formation (PubMed:27629706). Simultaneous knockdown with only Nep4 has no effect on LTM formation (PubMed:27629706).
messages: Secreted
messages: The soluble form is probably produced by proteolytic cleavage.

7227:Dmel CG5345
gene id: 7227:Dmel_CG5345
uniprot id: Q7JXZ2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

7227:Dmel CG8544
gene id: 7227:Dmel_CG8544
uniprot id: A8JUY5
uniprot id: A8JUY9
uniprot id: E1JJ99
uniprot id: M9PH78
uniprot id: P30052
uniprot id: Q8IR25
uniprot id: X2JFL9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Nucleus
messages: Subset of neuroblasts in the central nervous system and in the peripheral sense organs of the embryo. Expressed in the developing wing primordia initially along the D/V wing boundary, and by the late third larval instar, maximal expression is seen in cells at the D/V wing disk boundary. Less expression in cells located farther from this boundary. Also expressed in wing progenitor cells.
messages: The C-terminus of sd interacts with the C-terminal serine-rich protein domain of vg, to form a complex which acts as a selector for wing development. Interacts (via C-terminus) with yki (via N-terminus) and this interaction enhances its transcriptional activity.
messages: Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Sd promotes nuclear localization of Yki. Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system. When in combination with vestigial (vg) it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to vg switches the DNA target selectivity of sd. Required autonomously for cell proliferation and viability within the wing blade. Required for proper sensory organ precursor (SOP) differentiation at the wing margin; required for correct expression of sens.

7227:Dmel CG31198
gene id: 7227:Dmel_CG31198
uniprot id: Q8IN25
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG6814
gene id: 7227:Dmel_CG6814
uniprot id: Q9VEX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the asunder family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193,PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938).
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed in the nucleus during the G2 phase of primary spermatocytes at stages S3-S4. Distributed between the nucleus and the cytoplasm in G2 phase of primary spermatocytes at stage S5. Localized in the cytoplasm in G2 phase of primary spermatocytes at stage S6. Remains dispersed throughout the cell until the completion of meiosis when it becomes restricted from nuclei of onion-stage spermatides.
messages: Expressed in nurse cells at stages 9-10 of oogenesis and exported to the oocyte. Also expressed in the follicle cells surrounding the oocyte.
messages: Nucleus
messages: Phosphorylated.
messages: Results in almost complete steril males. Mature sperm formed in small amounts in testes are immotile or weakly motile; seminal vesicles are largely empty. Primary spermatocytes appeared normal (Cysts of 16 cells); however, spermatids show irregularities in nuclear size and number. Spermatocytes I exhibit failure of nucleus-centrosome coupling that normally occur upon meiotic phase entry; those that progress through meiotic divisions exhibit defects in spindle assembly and chromosome segregation. When injected into Xenopus embryos, causes developmental arrest with gastrulation defects and defective cell cycles resulting in polyploid nuclei. RNAi injection into HeLa cells or Drosophila syncytial embryos causes mitotic cell cycle, giving rise to multinucleated polyploidy cells.
messages: perinuclear region

7227:Dmel CG3206
gene id: 7227:Dmel_CG3206
uniprot id: D3PK91
uniprot id: O46077
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 20 sensory neurons on the distal edge of the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG12620
gene id: 7227:Dmel_CG12620
uniprot id: Q4V424
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

7227:Dmel CG1632
gene id: 7227:Dmel_CG1632
uniprot id: Q9W3H0
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG33807
gene id: 7227:Dmel_CG33807
uniprot id: Q4ABD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG3832
gene id: 7227:Dmel_CG3832
uniprot id: O01404
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Death as late embryos with morphological defects that resemble those of animals with mutations in genes of the ecdysone-inducible regulatory circuit. Amidated peptides are largely absent but peptide precursors, a nonamidated neuropeptide, nonpeptide transmitters, and other peptide biosynthetic enzymes are detected.
messages: Expressed in the central nervous system (CNS) in a small number of CNS neurons (approximately a few hundred). Expression is present both in cell bodies and within neuropil regions. It is strongly expressed in neuroendocrine neurons (at protein level).
messages: Monooxygenase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Produces an unstable peptidyl(2-hydroxyglycine) intermediate. C-terminal amidation of peptides is required for normal developmental transitions and for biosynthesis of secretory peptides throughout the life.
messages: Secreted
messages: Transcriptionally regulated by DIMM.

7227:Dmel CG5081
gene id: 7227:Dmel_CG5081
uniprot id: Q7K0X9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG12006
gene id: 7227:Dmel_CG12006
uniprot id: Q9VZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).

7227:Dmel CG3790
gene id: 7227:Dmel_CG3790
uniprot id: Q961J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Beta-alanine transporter required for the uptake of beta-alanine by the glia (PubMed:28806173). Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission (PubMed:28806173). Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine (PubMed:28806173).
messages: Cell membrane
messages: Expressed in the head and predominantly in the retinal pigment cells of the compound eye.

7227:Dmel CG6504
gene id: 7227:Dmel_CG6504
uniprot id: Q9VK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

7227:Dmel CG42514
gene id: 7227:Dmel_CG42514
uniprot id: Q0E8E1
uniprot id: Q9I7R2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10230
gene id: 7227:Dmel_CG10230
uniprot id: Q7KMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

7227:Dmel CG4720
gene id: 7227:Dmel_CG4720
uniprot id: Q9VDS9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

7227:Dmel CG12056
gene id: 7227:Dmel_CG12056
uniprot id: Q9W376
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein.
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 99 and 126.

7227:Dmel CG1402
gene id: 7227:Dmel_CG1402
uniprot id: Q9W3P7
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

7227:Dmel CG12759
gene id: 7227:Dmel_CG12759
uniprot id: Q07886
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: Probable ATP-binding RNA helicase.

7227:Dmel CG8582
gene id: 7227:Dmel_CG8582
uniprot id: M9MRQ6
uniprot id: M9MRR7
uniprot id: M9MSK4
uniprot id: Q9NFP5
names: Similarity
messages: Belongs to the SH3BGR family.

7227:Dmel CG4067
gene id: 7227:Dmel_CG4067
uniprot id: A0A0B4K623
uniprot id: E8NH74
uniprot id: O96553
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Present in all tissues.
messages: This trifunctional enzyme consists of two major domains: a N-terminal part, containing the methylene-THF dehydrogenase and the methenyl-THF cyclohydrolase activities and a larger formyl-THF synthetase domain.

7227:Dmel CG33239
gene id: 7227:Dmel_CG33239
uniprot id: Q7KV15
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG17139
gene id: 7227:Dmel_CG17139
uniprot id: Q9VKP3
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

7227:Dmel CG3780
gene id: 7227:Dmel_CG3780
uniprot id: Q9W424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

7227:Dmel CG11324
gene id: 7227:Dmel_CG11324
uniprot id: M9PB54
uniprot id: M9PEX1
uniprot id: O96607
uniprot id: Q0E8S7
uniprot id: Q9VM94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

7227:Dmel CG14225
gene id: 7227:Dmel_CG14225
uniprot id: M9NE35
uniprot id: Q9VWE1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG33803
gene id: 7227:Dmel_CG33803
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG17302
gene id: 7227:Dmel_CG17302
uniprot id: M9PE80
uniprot id: Q9VQE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG5276
gene id: 7227:Dmel_CG5276
uniprot id: Q9VGN8
names: Similarity
messages: Belongs to the apyrase family.

7227:Dmel CG6379
gene id: 7227:Dmel_CG6379
uniprot id: Q9W4N2
uniprot id: T2GGJ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via C-terminus) with r2d2 (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs (PubMed:32504809). Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1) (PubMed:32504809). Positively regulates the Ago2-dependent small RNA pathway, with roles in both siRNA biogenesis and RISC assembly (PubMed:32504809). Involved in facilitating conversion of pre-RISC into holo-RISC, possibly by promoting the unwinding of Ago2-bound siRNA duplexes and thus the retention of the guide strand in holo-RISC (PubMed:32504809).

7227:Dmel CG2917
gene id: 7227:Dmel_CG2917
uniprot id: Q9W102
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

7227:Dmel CG34063
gene id: 7227:Dmel_CG34063
uniprot id: J7FL05
uniprot id: P03896
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG12661
gene id: 7227:Dmel_CG12661
uniprot id: Q9W3A7
names: Similarity
messages: Belongs to the FAM136 family.

7227:Dmel CG7207
gene id: 7227:Dmel_CG7207
uniprot id: Q9Y128
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

7227:Dmel CG10542
gene id: 7227:Dmel_CG10542
uniprot id: Q9VRP9
uniprot id: X2JGB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
messages: Nucleus

7227:Dmel CG4585
gene id: 7227:Dmel_CG4585
uniprot id: A0A0B4LGC8
uniprot id: O77475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the biosynthesis of ceramide phosphoethanolamine (CPE) through the transfer of a phosphatidyl head group from cytidine 5'-diphosphate (CDP)-ethanolamine on to the primary hydroxyl of ceramide.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG30062
gene id: 7227:Dmel_CG30062
uniprot id: A1Z9D5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7227:Dmel CG13334
gene id: 7227:Dmel_CG13334
uniprot id: A1Z9F8
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

7227:Dmel CG18341
gene id: 7227:Dmel_CG18341
uniprot id: Q9W470
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG1994
gene id: 7227:Dmel_CG1994
uniprot id: H0RNM5
uniprot id: Q9W3C1
uniprot id: X2JD07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Component of the PRC1 complex (PSC, PC, PH and dRING1) in 0-12 hours Drosophila embryos. This complex is distinct from the Esc/E(z) complex, which contains many other PcG proteins like Esc, E(z), Su(z)12, HDAC1/Rpd3, Caf1-55 and probably Pho. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility (PubMed:11493925).
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

7227:Dmel CG31620
gene id: 7227:Dmel_CG31620
uniprot id: P58960
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons and in abdominal ganglions. In larvae, is expressed in neurons of the dorsal and posterior pharyngeal sense organs.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Has also atypical sensory function in organ not limited to conventional taste sensing like abdominal ganglions.

7227:Dmel CG6673
gene id: 7227:Dmel_CG6673
uniprot id: Q9VSL4
uniprot id: Q9VSL5
names: Similarity
messages: Belongs to the GST superfamily. Omega family.

7227:Dmel CG7611
gene id: 7227:Dmel_CG7611
uniprot id: Q7K0L4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: G-beta-like protein involved in cell signal transduction (By similarity).
messages: Mitochondrion

7227:Dmel CG4257
gene id: 7227:Dmel_CG4257
uniprot id: A0A0B4KGE1
uniprot id: A0A0B4KGI7
uniprot id: A0A0B4KH10
uniprot id: A0A0B4KHS6
uniprot id: A0A0B4KHS7
uniprot id: Q24151
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Exibits aberrant expression of the pair rule gene even-skipped at the cellular blastoderm stage, leading to larval segmentation defects.
messages: Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern.
messages: Forms a homodimer or a heterodimer with a related family member.
messages: Might play a role in signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression in early development as part of the Janus kinase-STAT pathway (PubMed:8608595). Might play a role in male germline stem cell maintenance (PubMed:34644293).
messages: Nucleus
messages: Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.

7227:Dmel CG3929
gene id: 7227:Dmel_CG3929
uniprot id: Q23985
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Deltex family.
messages: Cytoplasm
messages: Homomultimer; the oligomerization is required for its function. Interacts with the ankyrin repeats of Notch.
messages: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway.
messages: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
messages: Ubiquitous. Expressed at low levels throughout embryogenesis and in larvae.

7227:Dmel CG12177
gene id: 7227:Dmel_CG12177
uniprot id: Q9VYA1
names: Similarity
messages: Belongs to the IUNH family.

7227:Dmel CG4180
gene id: 7227:Dmel_CG4180
uniprot id: Q9V3Y2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

7227:Dmel CG3876
gene id: 7227:Dmel_CG3876
uniprot id: Q9VPT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).

7227:Dmel CG11501
gene id: 7227:Dmel_CG11501
uniprot id: Q9VAK8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Diedel family.
messages: By viral infection with Drosophila C virus (DCV), feline herpesvirus (FHV), Sindbis virus (SINV) and vesicular stomatitis virus (VSV). Strongest induction occurs with SINV and VSV. Highest levels of induction occur 6-24 hours after infection with levels declining steadily until 96 hours after infection. Induction requires the dorsal-related immunity factor Dif but does not require the myeloid differentiation primary response protein MyD88 (PubMed:26739560). By muscle tissue stress (PubMed:30036358).
messages: Contains two subdomains, SD1 and SD2. SD1 is composed of an antiparallel beta-sheet covered by an alpha-helix and displays a ferredoxin-like fold. SD2 displays a new protein fold made of loops connected by four disulfide bridges.
messages: Cytokine which promotes survival following infection by Sindbis virus by suppressing the immune deficiency pathway (PubMed:26739560). Following infection by the enteropathogenic bacteria E.carotovora limits intestinal stem cells proliferation (PubMed:30036358). When secreted from muscle or adipose tissue, can attenuate age-related intestinal tissue degeneration by inhibiting apoptosis (PubMed:30036358).
messages: Detected in hemolymph (at protein level). Also expressed in the fat body and is probably synthesized in the fat body and secreted into the hemolymph.
messages: Expressed in muscle and fat body with levels increasing in the adult stage.
messages: Mutants have a shortened lifespan and succumb more rapidly than controls to SINV infection (PubMed:26739560). RNAi-mediated knockdown in fat body leads to accelerated aging of the intestine with intestinal stem cell hyperproliferation, epithelial dysplasia and accelerated induction of apoptosis in the aging midgut (PubMed:30036358). RNAi-mediated knockdown in muscle had no impact on systemic intestinal tissue aging (PubMed:30036358).
messages: Secreted
messages: The name 'Diedel' is the German translation of Tweedle and is based on the fictional Lewis Carroll characters Tweedledum and Tweedledee due to the presence of two subdomains within the protein.

7227:Dmel CG7464
gene id: 7227:Dmel_CG7464
uniprot id: B7Z099
uniprot id: Q9VNW7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32638
gene id: 7227:Dmel_CG32638
uniprot id: Q8IR72
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6376
gene id: 7227:Dmel_CG6376
uniprot id: A0A0B4KGM3
uniprot id: A0A0B4LHG1
uniprot id: Q27368
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the E2F/DP family.
messages: Heterodimer of E2f and Dp. Cooperates to give sequence-specific DNA binding and optimal trans-activation. Interacts with PCNA.
messages: Nucleus
messages: Segmentally repeated expression throughout early embryos is restricted to the ventral nerve cord in later embryos.
messages: The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
messages: Throughout embryonic development.
messages: Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg.
messages: Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase. Ubiquitination by the DCX(DTL) complex is essential for cell cycle control and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation.

7227:Dmel CG18522
gene id: 7227:Dmel_CG18522
uniprot id: Q9VF53
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG1634
gene id: 7227:Dmel_CG1634
uniprot id: P20241
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Forms a complex with Nrx and Cont.
messages: Long isoform is restricted to surface of neurons and glia in the developing nervous system and the short isoform to other non-neuronal tissues.
messages: The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
messages: tight junction

7227:Dmel CG6208
gene id: 7227:Dmel_CG6208
uniprot id: Q9VH25
names: Similarity
messages: Belongs to the SNAP family.

7227:Dmel CG7931
gene id: 7227:Dmel_CG7931
uniprot id: C0MHU3
uniprot id: P20349
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the janus family.
messages: From the third-instar larval stage to the adult stage.
messages: Germline cells of adult males.
messages: JanA and janB regulate somatic sex differentiation.

7227:Dmel CG8881
gene id: 7227:Dmel_CG8881
uniprot id: Q7KJ69
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG34067
gene id: 7227:Dmel_CG34067
uniprot id: A0A075E6K7
uniprot id: P00399
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane
messages: There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts. In PubMed:19540318, further evidence for the presence of the same start codon coding for Ser in D.melanogaster CoI transcript is presented.

7227:Dmel CG42249
gene id: 7227:Dmel_CG42249
uniprot id: Q9VZ32
uniprot id: Q9VZ33
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

7227:Dmel CG14644
gene id: 7227:Dmel_CG14644
uniprot id: A0A0B4KFI9
uniprot id: Q8T4B6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7227:Dmel CG31445
gene id: 7227:Dmel_CG31445
uniprot id: Q95SR0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG32475
gene id: 7227:Dmel_CG32475
uniprot id: M9PBG4
uniprot id: Q9W0V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG13421
gene id: 7227:Dmel_CG13421
uniprot id: Q9V931
names: Function
names: Similarity
messages: Belongs to the PBP/GOBP family.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.

7227:Dmel CG5661
gene id: 7227:Dmel_CG5661
uniprot id: Q7YU67
uniprot id: Q9VTT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG4521
gene id: 7227:Dmel_CG4521
uniprot id: Q9VXD9
uniprot id: X2JC86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG12622
gene id: 7227:Dmel_CG12622
uniprot id: Q9VYZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily.
messages: Cell membrane
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG4780
gene id: 7227:Dmel_CG4780
uniprot id: Q9VRL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Part of a unique SNARE complex.
messages: cis-Golgi network membrane

7227:Dmel CG8365
gene id: 7227:Dmel_CG8365
uniprot id: P13098
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (PubMed:22357926). Heterodimers with dpn (PubMed:22357926).Transcription repression requires formation of a complex with a corepressor protein (Groucho) (PubMed:8001118).
messages: In larvae, detected in neuroblasts (at protein level) (PubMed:22357926). Mesectodermal expression appears shortly before the onset of gastrulation (PubMed:2540957). In imaginal disks, expression is seen primarily within presumptive proneural clusters of eye-antennal, wing and leg disks (PubMed:2540957).
messages: Nucleus
messages: Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo (PubMed:2540957). Transcriptional repressor (PubMed:8001118). Binds DNA on N-box motifs: 5'-CACNAG-3' (PubMed:8001118). Part of the Notch signaling pathway (PubMed:22357926).
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
messages: The orange domain and the basic helix-loop-helix motif mediate repression of specific transcriptional activators, such as basic helix-loop-helix protein dimers.

7227:Dmel CG10016
gene id: 7227:Dmel_CG10016
uniprot id: Q9VQS6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Has two temporally distinct modes of expression during early embryogenesis. Expressed in seven stripes at the blastoderm stage, then during gastrulation the seven primary stripes are supplemented by seven secondary stripes which appear in alternate segments. This results in the labelling of each of the 14 segments in the extended germ band. Also expressed in the anterior gut primordium starting at stage 5 and in the embryonic foregut (including the proventriculus) and hindgut. Strongly expressed in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4. In early third instar leg disks, expression starts in a proximal ring corresponding to the presumptive coxa. The number of segmental rings progressively increases to 5 by the end of larval development.
messages: Interacts with lin.
messages: Nucleus
messages: Putative transcription factor. May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation. Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.
messages: The C2H2-type domain 1 is essential for binding to and repressing lin, while the C2H2-type domain 2 contributes to lin binding.

7227:Dmel CG9127
gene id: 7227:Dmel_CG9127
uniprot id: P35421
names: Disruption Phenotype
names: Function
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway (PubMed:3086869). Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (PubMed:3086869). Because of its role in metabolisms, is involved in sleep regulation (PubMed:3086869).
messages: Pupal lethal (PubMed:21441212). RNAi-mediated knockdown in the fat body reduces energy storage of both triglyceride and free glucose, increases waking activity during the day and the night, reduces sleep bout length, with total sleep bout number reduced during the day and increased during the night (PubMed:30249751).

7227:Dmel CG6652
gene id: 7227:Dmel_CG6652
uniprot id: Q9VVD0
names: Similarity
messages: Belongs to the LCA5 family.

7227:Dmel CG17333
gene id: 7227:Dmel_CG17333
uniprot id: Q9VZ64
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

7227:Dmel CG9913
gene id: 7227:Dmel_CG9913
uniprot id: Q7KSK2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG8931
gene id: 7227:Dmel_CG8931
uniprot id: Q9VXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG12858
gene id: 7227:Dmel_CG12858
uniprot id: A1Z9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7227:Dmel CG30176
gene id: 7227:Dmel_CG30176
uniprot id: P82804
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Expression detected in the ovary. In the oocyte expressed in the germarium, nurse cell and follicle cell.
messages: Interacts (via N-terminus) with mago and tsu/RBM8A; the interaction is direct.
messages: Nucleus
messages: Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit or components of the translation initiation complex. May not function in cap-dependent translation regulation.
messages: Viable and fertile. No visible phenotype.

7227:Dmel CG33169
gene id: 7227:Dmel_CG33169
uniprot id: A0A1B2AL38
uniprot id: Q8SY72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

7227:Dmel CG33878
gene id: 7227:Dmel_CG33878
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG17266
gene id: 7227:Dmel_CG17266
uniprot id: Q4V5H1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG9089
gene id: 7227:Dmel_CG9089
uniprot id: Q9VX95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: May function as a co-chaperone.
messages: Membrane

7227:Dmel CG17436
gene id: 7227:Dmel_CG17436
uniprot id: A0A021WW32
uniprot id: O96689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

7227:Dmel CG13436
gene id: 7227:Dmel_CG13436
uniprot id: A1ZBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

7227:Dmel CG31802
gene id: 7227:Dmel_CG31802
uniprot id: Q8T415
names: Similarity
messages: Belongs to the centrin family.

7227:Dmel CG1131
gene id: 7227:Dmel_CG1131
uniprot id: A0A0B4K604
uniprot id: A0A0B4K6L1
uniprot id: Q9I7L5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG44746
gene id: 7227:Dmel_CG44746
uniprot id: P40421
names: Cofactor
names: Function
names: Sequence Caution
names: Similarity
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family.
messages: Binds 2 manganese ions per subunit.
messages: Expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain.
messages: Intron retention.
messages: Phosphatase required to prevent light-induced retinal degeneration.

7227:Dmel CG13957
gene id: 7227:Dmel_CG13957
uniprot id: Q9VXH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458).
messages: Belongs to the SWIP family.
messages: Component of the WASH complex.
messages: Early endosome

7227:Dmel CG8536
gene id: 7227:Dmel_CG8536
uniprot id: Q7KN92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the transfer of galactose onto proteins or lipids.
messages: Membrane

7227:Dmel CG32154
gene id: 7227:Dmel_CG32154
uniprot id: Q9VV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

7227:Dmel CG3730
gene id: 7227:Dmel_CG3730
uniprot id: Q9U6Y9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA) (By similarity). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. Required for arginine symmetrical dimethylation of piwi family proteins, piwi, aub and AGO3, during germline development. Required during oogenesis for pole cell formation in the pathway controlled by oskar (osk) and for abdominal segments during early embryogenesis. Involved in nanos (nos) and germ cell mRNAs localization.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed from stage 3 egg chambers onward, becoming restricted to the cortex of the oocytes at stage 10. Evenly distributed in preblastoderm embryos.
messages: Expressed only in ovaries.
messages: Flies are viable and do not display neuromuscular dysfunctions. Strong synthetic lethal phenotype in the presence of a hypomorphic Smn mutation.
messages: Interacts with vls.

7227:Dmel CG5265
gene id: 7227:Dmel_CG5265
uniprot id: Q9VEM4
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7227:Dmel CG8860
gene id: 7227:Dmel_CG8860
uniprot id: A0A1B2AK15
uniprot id: Q9V668
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

7227:Dmel CG5157
gene id: 7227:Dmel_CG5157
uniprot id: Q9VUZ3
names: Similarity
messages: Belongs to the cytochrome b5 family.

7227:Dmel CG10363
gene id: 7227:Dmel_CG10363
uniprot id: M9PD73
uniprot id: M9PDF6
uniprot id: M9PDR0
uniprot id: Q9VIT9
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

7227:Dmel CG7261
gene id: 7227:Dmel_CG7261
uniprot id: Q9VQ78
names: Similarity
messages: Belongs to the TBCD family.

7227:Dmel CG2852
gene id: 7227:Dmel_CG2852
uniprot id: Q9W227
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG1451
gene id: 7227:Dmel_CG1451
uniprot id: A0A126GV30
uniprot id: Q9VAS9
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

7227:Dmel CG33245
gene id: 7227:Dmel_CG33245
uniprot id: Q7KV12
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG7718
gene id: 7227:Dmel_CG7718
uniprot id: Q8SYL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

7227:Dmel CG5863
gene id: 7227:Dmel_CG5863
uniprot id: Q9VEK3
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG11680
gene id: 7227:Dmel_CG11680
uniprot id: P24785
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Chromosome
messages: Expressed throughout development; highest in embryos and at equal levels in males and females.
messages: Interacts with Top2.
messages: Nucleus
messages: Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X-chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction.

7227:Dmel CG33243
gene id: 7227:Dmel_CG33243
uniprot id: Q7KV19
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG7085
gene id: 7227:Dmel_CG7085
uniprot id: Q9VQ93
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homooligomer (By similarity). Interacts with botv, Ext2 and ttv (PubMed:23720043). Interacts with Vti1 (PubMed:23720043). Interacts with Vps35, Rab5, Chc, Rab11, zip, Pav and Septin1 (PubMed:24786584).
messages: Lethal (PubMed:23720043, PubMed:24786584). Embryos display an aberrant pattern of denticles with some additional dorsalization and twisting (PubMed:23720043). It is associated with a defect in heparan sulfate proteoglycan synthesis which in turn alters hedgehog signaling (PubMed:23720043).
messages: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi (PubMed:19837035, PubMed:24786584). Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking (PubMed:23720043, PubMed:24786584). May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression (PubMed:24786584). May also have a role in the intital steps of central spindle formation (PubMed:24786584). Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro (PubMed:24786584).

7227:Dmel CG4751
gene id: 7227:Dmel_CG4751
uniprot id: Q9VKJ1
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase M67 family.
messages: Probable protease.
messages: The JAMM motif may mediate the protease activity.

7227:Dmel CG8683
gene id: 7227:Dmel_CG8683
uniprot id: Q9VLT1
uniprot id: X2J564
names: Function
names: Similarity
messages: Belongs to the MON2 family.
messages: May be required for traffic between late Golgi and early endosomes.

7227:Dmel CG10093
gene id: 7227:Dmel_CG10093
uniprot id: D4G7E5
uniprot id: Q9VGB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG30483
gene id: 7227:Dmel_CG30483
uniprot id: A0A0B4K7Z0
uniprot id: A0A0B4LF25
uniprot id: A0A0B4LFA9
uniprot id: A1Z9K8
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG12512
gene id: 7227:Dmel_CG12512
uniprot id: Q9VMR6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG1132
gene id: 7227:Dmel_CG1132
uniprot id: D3PFH7
uniprot id: Q02360
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryonic posterior mesoderm.
messages: Expressed in embryos, maximal level between 5-12 hours.
messages: Involved in development during embryogenesis.
messages: Nucleus

7227:Dmel CG10212
gene id: 7227:Dmel_CG10212
uniprot id: Q7KK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

7227:Dmel CG17246
gene id: 7227:Dmel_CG17246
uniprot id: Q94523
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Disruption of mitochondrial function has no effect on the initial stages of photoreceptor development (R cells develop normally, adopt the correct cell fates, innervate the appropriate synaptic partners, and assemble synapses normally). However, beginning around the time of eclosion, R cells degenerate, progressively losing expression of synaptic markers and undergoing extensive morphological changes. Synapse loss is caused by reactive oxygen species (ROS) production, not energy depletion, as photoreceptor ATP levels are normal.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
messages: Mitochondrion inner membrane

7227:Dmel CG12262
gene id: 7227:Dmel_CG12262
uniprot id: G3KKP7
uniprot id: Q9VSA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: This enzyme is specific for acyl chain lengths of 4 to 16.

7227:Dmel CG8564
gene id: 7227:Dmel_CG8564
uniprot id: M9PEV1
uniprot id: Q9VS63
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG10790
gene id: 7227:Dmel_CG10790
uniprot id: P26023
names: Developmental Stage
names: Tissue Specificity
messages: Low expression in first to third instar larvae salivary glands.
messages: Throughout the larval period.

7227:Dmel CG17943
gene id: 7227:Dmel_CG17943
uniprot id: Q24139
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the commissureless family.
messages: Cell membrane
messages: Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone.
messages: Cytoplasmic vesicle membrane
messages: Interacts (probably via PY-motifs) with Nedd4 (via WW2 domain) (PubMed:12165468, PubMed:16531238). Interacts with Robo (PubMed:12165468).
messages: The cytoplasmic domain is required for function in axon guidance.
messages: Ubiquitinated by Nedd4; which promotes endocytosis of the comm/robo complex and comm proteasomal degradation (PubMed:12165468). Not ubiquitinated by Nedd4 (PubMed:15657595).

7227:Dmel CG6562
gene id: 7227:Dmel_CG6562
uniprot id: Q5U0V7
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

7227:Dmel CG7479
gene id: 7227:Dmel_CG7479
uniprot id: Q9VZ82
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG34117
gene id: 7227:Dmel_CG34117
uniprot id: Q0KI97
names: Similarity
messages: Belongs to the FMC1 family.

7227:Dmel CG32380
gene id: 7227:Dmel_CG32380
uniprot id: Q9VS60
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: A phosphatidylethanolamine (PE)/ceramide ethanolamine phosphotransferase that catalyzes the synthesis of ceramide phosphoethanolamines (CPE), a class of lipids that is a sphingomyelin analog and a major membrane constituent in Drosophila. Transfers the head group from PE (1,2-diacyl-sn-glycero-3-phosphoethanolamine) on to different ceramides such as N-acylsphinganine (dihydroceramide) and N-acyl-(4R)-hydroxysphinganine (phytoceramide) to form N-acyl-sphinganine-1-phosphoethanolamine and N-acyl-(4R)-hydroxysphinganine-1-phosphoethanolamine, respectively. Operates as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum, which is critical for the integrity of the early secretory pathway.
messages: Belongs to the sphingomyelin synthase family.
messages: Endoplasmic reticulum membrane
messages: Probable cloning artifact.
messages: The SAM domain is required to retain SMSR in the endoplasmic reticulum.

7227:Dmel CG5857
gene id: 7227:Dmel_CG5857
uniprot id: Q9VCG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.
messages: Nucleus membrane
messages: nuclear pore complex

7227:Dmel CG32843
gene id: 7227:Dmel_CG32843
uniprot id: A0A0B4KEN5
uniprot id: A0A0B4KF12
uniprot id: A1Z9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG7424
gene id: 7227:Dmel_CG7424
uniprot id: Q9VLT7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

7227:Dmel CG8453
gene id: 7227:Dmel_CG8453
uniprot id: B6IDY5
uniprot id: Q9V674
names: Developmental Stage
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: 91-R, Hikone-R, WC2 and Wisconsin are insecticide resistant strains, 91-C, Canton-S and Oregon-RC are insecticide susceptible. Cyp6g1 is more highly expressed in the resistant strains.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed throughout development, low levels in embryos and first and second instar larvae, levels increase from third instar through to adult.
messages: Microsome membrane
messages: Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones.

7227:Dmel CG16817
gene id: 7227:Dmel_CG16817
uniprot id: A0A0B4K6D2
uniprot id: Q9VH95
names: Similarity
messages: Belongs to the p23/wos2 family.

7227:Dmel CG17712
gene id: 7227:Dmel_CG17712
uniprot id: Q9Y153
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

7227:Dmel CG18374
gene id: 7227:Dmel_CG18374
uniprot id: Q8IRJ9
uniprot id: Q9W0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

7227:Dmel CG43729
gene id: 7227:Dmel_CG43729
uniprot id: A0A0B4KER3
uniprot id: A0A0B4KEV7
uniprot id: A0A0B4KFR2
uniprot id: A0A0B4KG20
uniprot id: A0A0B4LFI1
uniprot id: A0A0B4LGK0
uniprot id: A8DYE9
names: Subcellular Location Annotation
messages: sarcolemma

7227:Dmel CG1625
gene id: 7227:Dmel_CG1625
uniprot id: A1Z7Z9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CEP131 family.
messages: Cilium-specific protein with a role in cilium/flagellum formation (PubMed:21750193, PubMed:27646273). May be involved in transport of components into the growing cilium (PubMed:21750193). In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme (PubMed:27646273).
messages: Displays reduced climbing ability and die very soon after eclosion (PubMed:21750193). Loss of protein expression leads to truncated sensory cilia formation and impaired intraflagellar transport processes (PubMed:21750193). Simultaneous knockout of Cby and dila results in lack of motor coordination and absence of cilia in chordotonal neurons where centrioles fail to build a transition zone and Cep290 and Mks1 are mis-localized. Males are sterile: aberrant microtubule extensions, lack of ciliary cap and mislocalization of Mks1 and B9d1 to the basal body result in failure of axoneme formation and lack of mature sperm; sperm cysts fail to elongate whereas the overall size of the testes is not reduced (PubMed:27646273).
messages: Expressed in chordotonal (Ch) neuronal precursors. Expressed in ciliated cells, like sensory neurons and spermatids.
messages: Expressed in developing and differentiating ciliated sensory neurons of both the chordotonal (Ch) mechanosensory neurons and external sensory (ES) cells.
messages: centriole
messages: centrosome
messages: cilium basal body

7227:Dmel CG8939
gene id: 7227:Dmel_CG8939
uniprot id: Q9VXK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
messages: nucleolus

7227:Dmel CG15002
gene id: 7227:Dmel_CG15002
uniprot id: Q9VZH2
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Embryonic lethal as a result of neuronal defects in the central nervous system (CNS) and peripheral nervous system (PNS) from stage 15, and defective muscle attachment from stage 16 (PubMed:7851790, PubMed:8817456). Defects in the CNS include stalling of the growth cones of pioneer axons of anterior and posterior corner cells (aCC and pCC) leading to abnormalities in the horizontal commissures and discontinuities in the longitudinal connectives respectively (PubMed:8817456). Defects in the PNS include defects in the location of the sense organs and in their projections in the sensory nerves, including missing neurons and more often defects in the axonal paths with erroneous connections with the ventral ganglia (PubMed:8817456). Defects in muscle attachment include the appearance of myospheroid-like bodies and the collapse of lateral transverse muscles 1-3 (PubMed:7851790).
messages: In embryogenesis, has a role in somatic muscle attachment and in the development of axonal pathways probably by stabilizing cell-matrix adhesion and/or by acting as a competitive antagonist of serine proteases.
messages: In embryos, from stage 14 till stage 17, expressed in epidermal cells, tracheal system and denticle belts (at protein level) (PubMed:7851790). In larva and in early pupa, expressed in brain cells along the ventral midline, in cell bodies in the cellular cortex of the ventral nerve cord, in cells contributing to the perineum around the cerebral hemispheres and in axons of the longitudinal connectives of the central nervous system (CNS); at low level, expressed throughout the antennal disk (at protein level) (PubMed:7851790, PubMed:8817456). In pupae, expressed in pupal appendages and body epidermis, in the proboscis and pseudotrachea (at protein level) (PubMed:8817456). Expressed in embryos; from stage 11 until the end of stage 13 expressed in small cells along the midline of the central nervous system; at state 12, expressed in the epidermis; from stage 13 onwards, expressed in the epidermal cells in particular in the anterior border of each segment; from stage 14-17, detected in the cells of the tracheal system (PubMed:7851790). Detected in larva and pupa, but not in adult flies (PubMed:7851790, PubMed:8817456).
messages: Lacks the conserved Ser residue within the catalytic triad which is replaced by a Gly residue, probably resulting in a loss of proteolytic activity.
messages: Proteolytically cleaved and thereafter secreted.
messages: Secreted
messages: The CLIP domain consists of 37-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
messages: axon

7227:Dmel CG33182
gene id: 7227:Dmel_CG33182
uniprot id: Q9V6L0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).

7227:Dmel CG5127
gene id: 7227:Dmel_CG5127
uniprot id: Q9VBR1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

7227:Dmel CG6030
gene id: 7227:Dmel_CG6030
uniprot id: A0A0B4LHL7
uniprot id: Q24251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase d subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

7227:Dmel CG12822
gene id: 7227:Dmel_CG12822
uniprot id: A1Z759
uniprot id: Q8MR50
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

7227:Dmel CG3895
gene id: 7227:Dmel_CG3895
uniprot id: Q9NF31
uniprot id: Q9W523
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG4944
gene id: 7227:Dmel_CG4944
uniprot id: O97428
uniprot id: Q8IRS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: cytoskeleton

7227:Dmel CG15270
gene id: 7227:Dmel_CG15270
uniprot id: M9PCX9
uniprot id: Q7KT76
uniprot id: Q9V416
uniprot id: X2J9Y1
uniprot id: X2JE80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG4832
gene id: 7227:Dmel_CG4832
uniprot id: P54623
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Core component of the centrosome throughout spermatogenesis. May participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. Is a target of several homeotic genes.
messages: Cytoplasm
messages: Developing visceral mesoderm of the midgut, the central and peripheral nervous system, and developing gonads. Isoform J: Expressed in ovaries, testis and embryos. Isoform A: Expressed in testis only.
messages: Expressed both maternally and zygotically.
messages: Monomer.
messages: centrosome
messages: flagellum basal body

7227:Dmel CG4451
gene id: 7227:Dmel_CG4451
uniprot id: Q9VDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

7227:Dmel CG11594
gene id: 7227:Dmel_CG11594
uniprot id: Q9VZJ8
names: Similarity
messages: Belongs to the FGGY kinase family.

7227:Dmel CG30093
gene id: 7227:Dmel_CG30093
uniprot id: Q4QPY7
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

7227:Dmel CG2096
gene id: 7227:Dmel_CG2096
uniprot id: H5V895
uniprot id: P48462
uniprot id: Q8T0U6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Interacts with Nop17l (PubMed:17007873). Interacts with uri; uri inhibits flw phosphatase activity (PubMed:18412953).
messages: Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development.

7227:Dmel CG5581
gene id: 7227:Dmel_CG5581
uniprot id: P20240
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Cytoplasm
messages: Expressed in all cell types of the germarium and testis (PubMed:18410727, PubMed:27174470). Expressed in nurse cells, follicle cells and oocytes (PubMed:9199347).
messages: Inner nuclear membrane protein (PubMed:2186029, PubMed:9199347, PubMed:18410727, PubMed:22751930). Involved in the attachment of membrane vesicles to chromatin during nuclear assembly, and is probably required for centrosome maturation and cell cycle progression during mitosis (PubMed:9199347, PubMed:22751930). Essential for differentiation of certain tissues and the maintenance of progenitor cell populations (PubMed:18410727, PubMed:24700158, PubMed:23806619, PubMed:27174470). Required for the differentiation and maintenance of male and female germline stem cells (GSCs), as well as the maintenance of somatic cells in the GSC niche (PubMed:18410727, PubMed:23806619, PubMed:27174470). This role is likely to be independent of the BMP (Dpp) pathway that negatively regulates bam transcription during GSC differentiation (PubMed:18410727, PubMed:23806619). During development, plays essential and redundant functions with the other LEM domain proteins; bocks and MAN1 (PubMed:24700158). Also has a redundant but important role with bocks during larval development (PubMed:24700158).
messages: Interacts with Med (PubMed:18410727). Interacts with Lam (PubMed:9632815, PubMed:22751930). Interacts with aurA, alphaTub84B, gammaTub23C and gammaTub37C (PubMed:22751930). Interacts with Nemp (PubMed:32923640).
messages: No obvious phenotype (PubMed:18410727, PubMed:23806619, PubMed:24700158). However females are sterile and aging males become prematurely sterile (PubMed:18410727, PubMed:23806619). Males and females exhibit a range of defects in their germarium that may be age dependent phenotypes (PubMed:18410727, PubMed:23806619, PubMed:27174470). Most phenotypes result from defects in germline stem cell (GSC) differentiation that often lead to GSC loss (PubMed:23806619, PubMed:27174470). Also affects somatic cells of the ovarian stem cell niche, with delayed terminal filament formation and cap cell loss (PubMed:27174470). In 10 day old males, stem cell niches display a decrease in hub cell number but somatic cyst stem cells are unaffected (PubMed:27174470). No significant decrease in adult survival, however double mutants with either bocks or Man1 do not survive to the adult stage (PubMed:24700158). Double bocks and Ote mutant larvae have small brains, their imaginal disks are reduced in size or absent, and only 10% of second-instar larvae reach the pupal stage (PubMed:24700158). In Ote and MAN1 double mutants, pupal survival and larval development is unaffected (PubMed:24700158).
messages: Nucleus inner membrane
messages: Phosphorylation at Thr-63 by aurA may be required for exit from mitosis (PubMed:22751930). May be phosphorylated by Cdk1 and Pka-C1 (PubMed:9199347).
messages: Relatively high levels of expression in eggs and 1st instar larvae compared to pupal and adult stages, with weak expression in 2nd instar larvae (at protein level) (PubMed:16439308). Expressed throughout development in all somatic cells (PubMed:9199347). Highest levels of expression in embryos and weak expression in larvae and adults (PubMed:2186029, PubMed:9199347). Expressed throughout development (at protein level) (PubMed:2517292).
messages: centrosome
messages: nucleoplasm
messages: spindle pole

7227:Dmel CG7002
gene id: 7227:Dmel_CG7002
uniprot id: M9PCE5
uniprot id: Q9VU94
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7875
gene id: 7227:Dmel_CG7875
uniprot id: A0A0B4KHH9
uniprot id: P19334
uniprot id: U3PXB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
messages: Cell membrane
messages: Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.
messages: Membrane
messages: Phosphorylated by inaC.
messages: The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC), inaC (PKC), and possibly trpl, ninaC, Fkbp59, calmodulin and rhodopsin. Forms homomultimers and heteromultimers with trpl. Interaction with trpl is mediated in part by the N-terminal region and the transmembrane domains. Also interacts, though to a lower extent, with Trpgamma.

7227:Dmel CG8979
gene id: 7227:Dmel_CG8979
uniprot id: A0A0B4KEK7
uniprot id: Q9V637
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylation by Tnks increases its affinity for assembly chaperones PSMD9 and PMSD5, sequestering them away from the proteasome Rpt base subunits and promoting in this way 26S proteasome assembly. Also interferes with its inhibitory effect on 20S proteasome.
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Expressed in adults.
messages: In testis, expressed in germline stem cells and primary spermatocytes (at protein level).
messages: Interacts with ntc. Interacts with Tnks (via ANK repeats). Interacts with 20S proteasome subunits Prosalpha1, Prosalpha3, Prosalpha4 and Prosalpha6, but not with Prosalpha2 and Prosalpha5. The interaction with Prosalpha4 is reduced by PI31 ADP-ribosylation. Interacts with the 19S assembly chaperones PSMD5 and PSMD9; these interactions are increased by PI31 ADP-ribosylation.
messages: Larval lethal. Mutant larvae develop melanotic tumors.
messages: Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression.
messages: The Hydrophobic-Tyrosine-X (HbYX) motif is involved in proteasome activation.

7227:Dmel CG13551
gene id: 7227:Dmel_CG13551
uniprot id: Q0E8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mitochondrion

7227:Dmel CG10275
gene id: 7227:Dmel_CG10275
uniprot id: Q9VJ82
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG13809
gene id: 7227:Dmel_CG13809
uniprot id: Q9W040
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT172 family.
messages: Required for the maintenance and formation of cilia.
messages: cilium

7227:Dmel CG7221
gene id: 7227:Dmel_CG7221
uniprot id: Q9VLU5
uniprot id: X2J7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity).

7227:Dmel CG9246
gene id: 7227:Dmel_CG9246
uniprot id: Q9VIF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOC2 family.
messages: Nucleus

7227:Dmel CG30191
gene id: 7227:Dmel_CG30191
uniprot id: Q8MLS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3301
gene id: 7227:Dmel_CG3301
uniprot id: Q9VDC0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG3172
gene id: 7227:Dmel_CG3172
uniprot id: Q9VFM9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form.
messages: Maternally expressed. Ubiquitously expressed in embryos and throughout development.
messages: cell cortex
messages: cytoskeleton

7227:Dmel CG7219
gene id: 7227:Dmel_CG7219
uniprot id: Q9VLU4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: RNAi-mediated knockdown is often lethal at the pupal stage, with flies displaying small black or brown spots prior to death. A small percentage of adults survive when grown at 23 degrees Celsius to preclude pupal lethality. These adult escapers (then kept at 29 degrees Celsius) do not display melanotic areas until several hours after eclosion. These melanotic regions or spots are predominately in air-exposed parts of the body, such as those close to the cuticle, and the thoracic and abdominal spiracles. In the tracheae melanization occurs only in the trunk closest to the spiracle. The ptilinal suture and the surrounding area between the eyes also display various amounts of melanization. Around half display reduced pigmentation of their abdomen, and this often occurred in adults that had large melanotic areas. After septic injury, flies display impaired melanization at the wound site, and in their hemolymph there is an overall reduction in the protein level of PPO1 and no significant activity of PO.
messages: Secreted
messages: Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction (PubMed:18801354, PubMed:22227521). Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults (PubMed:18801354, PubMed:22227521). Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea (PubMed:18801354, PubMed:22227521). May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and pigmentation (PubMed:18801354).
messages: Up-regulated by injury in larvae and adults.

7227:Dmel CG7907
gene id: 7227:Dmel_CG7907
uniprot id: Q4V551
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

7227:Dmel CG8995
gene id: 7227:Dmel_CG8995
uniprot id: M9NDY2
uniprot id: Q9VXN9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Expressed in hemolymph. Localizes at the lumenal surface of the trachea (at protein level).
messages: Highly expressed in 0-5 hours embryos and in adult females, suggesting that it is expressed maternally.
messages: Monomer. Peptidoglycan binding induces oligomerization.
messages: Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram-negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is required for infection-dependent activation of melanization. Required for Relish processing and nuclear translocation following proteolytic cleavage. Its localization suggests a role in the recognition and subsequent activation of the signaling at the first point of contact with invading bacteria.
messages: Secreted

7227:Dmel CG5433
gene id: 7227:Dmel_CG5433
uniprot id: M9PF24
uniprot id: M9PFG7
uniprot id: P46824
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: The light chain is composed of three structural domains: a large globular N-terminal domain which may be involved in binding to kinesin heavy chains, a central alpha-helical coiled-coil domain that mediates the light chain dimerization; and a small globular C-terminal which may play a role in regulating mechanochemical activity or attachment of kinesin to membrane-bound organelles.
messages: Ubiquitous.
messages: cytoskeleton

7227:Dmel CG34145
gene id: 7227:Dmel_CG34145
uniprot id: M9PI08
uniprot id: Q0KHQ3
uniprot id: R9PY33
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG2104
gene id: 7227:Dmel_CG2104
uniprot id: Q9VNG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG10043
gene id: 7227:Dmel_CG10043
uniprot id: A8DZ19
uniprot id: A8DZ20
uniprot id: C3KGL5
uniprot id: M9PBE8
uniprot id: M9PGB1
uniprot id: Q9VIN1
names: Subcellular Location Annotation
messages: lamellipodium

7227:Dmel CG31936
gene id: 7227:Dmel_CG31936
uniprot id: P58953
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons.
messages: Taste bristles on the labial palp, labral and cibarial sense organs, chemosensory bristles on the leg and anterior wing margin. In larvae, is expressed in neurons of the terminal external chemosensory organ and in the dorsal pharyngeal sense organ. Neurons expressing Gr22e also express Gr66a and correspond to taste neurons that mediate sensitivity to bitter compounds.

7227:Dmel CG7579
gene id: 7227:Dmel_CG7579
uniprot id: Q8IA41
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to polypeptide N-acetylgalactosaminyltransferase proteins, it lacks the conserved Asp-Xaa-His motif in positions 199-201 and the conserved His residue in position 330 which are involved in the binding to the cofactor Mn(2+). This suggests that it may have lost its activity.
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Probable inactive glycosyltransferase.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG16874
gene id: 7227:Dmel_CG16874
uniprot id: Q9VKI3
uniprot id: X2J9F7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the vitelline membrane family.
messages: Expressed during vitelline membrane biosynthesis.
messages: Expressed in stage 10 egg-chambers, localized in the outer eggshell (chorion membrane).
messages: Major early eggshell protein.
messages: Secreted

7227:Dmel CG32318
gene id: 7227:Dmel_CG32318
uniprot id: Q7KVC2
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG6699
gene id: 7227:Dmel_CG6699
uniprot id: O62621
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

7227:Dmel CG4422
gene id: 7227:Dmel_CG4422
uniprot id: Q9VLB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

7227:Dmel CG11765
gene id: 7227:Dmel_CG11765
uniprot id: Q7JX87
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

7227:Dmel CG3461
gene id: 7227:Dmel_CG3461
uniprot id: O18399
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

7227:Dmel CG5085
gene id: 7227:Dmel_CG5085
uniprot id: Q9I7I7
uniprot id: R4HZM7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Causes lethality during development. Induced silencing shortens life span.
messages: NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.

7227:Dmel CG17137
gene id: 7227:Dmel_CG17137
uniprot id: Q9VKP2
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

7227:Dmel CG42277
gene id: 7227:Dmel_CG42277
uniprot id: Q9VI93
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with nab; which acts as a corepressor.
messages: Isoform rn and isoform roe are expressed in non-overlapping domains in the larval imaginal disks. Isoform rn is first expressed during the early third larval instar in the leg, wing, haltere and antennal part of the eye-antennal imaginal disk. It is observed as a ring in the leg and antenna disks and in the presumptive wing pouch and capitellum of wing and haltere disks respectively. In wing disk it is expressed in 3 concentric domains in the wing pouch. In late third instar, expression of isoform rn in the leg disk is no longer evident, but is maintained in the other disks. Isoform roe appears in the third instar and is confined to the eye part of the eye-antennal imaginal disk in a band of 4-6 cells at the morphogenetic furrow. There is no evidence of roe expression in other imaginal disks.
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Transcription factor involved in imaginal disks development. Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk. Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment. Also required for the epithelial-mesenchymal transition branch of basolateral junctions signaling.

7227:Dmel CG5634
gene id: 7227:Dmel_CG5634
uniprot id: Q9VB20
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG16910
gene id: 7227:Dmel_CG16910
uniprot id: Q9GYV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response.
messages: Interacts with IKKbeta to form the I-kappa-B kinase complex.
messages: Nucleus

7227:Dmel CG5919
gene id: 7227:Dmel_CG5919
uniprot id: Q9VDC2
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

7227:Dmel CG14211
gene id: 7227:Dmel_CG14211
uniprot id: Q9VWF4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response.
messages: Inhibited by the tyrosine phosphatase inhibitor sodium vanadate.
messages: Interacts (via tyrosine-protein phosphatase domain) with bsk/JNK; the interaction dephosphorylates bsk.
messages: Nucleus

7227:Dmel CG2736
gene id: 7227:Dmel_CG2736
uniprot id: Q9W0X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG5109
gene id: 7227:Dmel_CG5109
uniprot id: A0A0B4KEZ1
uniprot id: Q24459
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Polycomblike family.
messages: Chromosome
messages: Component of a form of the Esc/E(z) complex present specifically during early embryogenesis which is composed of Caf1-55, esc, E(z), Su(z)12, Pcl and HDAC1/Rpd3. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.
messages: In contrast to vertebrate homologs (PHF1, PHF19 and MTF2), the Tudor domain does not bind H3K36me3 (PubMed:23104054 and PubMed:23142980).
messages: Nucleus
messages: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. Required for the correct spatial expression of the homeotic genes of the Antennapedia and Bithorax complexes.
messages: The PHD-type zinc fingers mediate the interaction with E(z).
messages: Ubiquitous expression in embryos.

7227:Dmel CG6222
gene id: 7227:Dmel_CG6222
uniprot id: P22293
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At all stages.
messages: Belongs to the suppressor of sable family.
messages: Chromosome
messages: Interacts with Wdr82.
messages: Nucleus
messages: RNA-binding protein that suppresses transcription of some RNAs (PubMed:1703632, PubMed:9121479, PubMed:11027289, PubMed:15082769, PubMed:19687295, PubMed:26577379). Together with Wdr82, part of a transcription termination checkpoint that promotes transcription termination of RNAs and their subsequent degradation by the nuclear exosome (PubMed:26577379). Promotes transcription termination of aberrant RNAs, transcripts from genes containing a transposon inserted at their very 5' end or RNAs from heat-shock-inducible repetitive element (PubMed:1703632, PubMed:19687295, PubMed:26577379). Binds RNA preferentially at a sequence that resembles a cryptic 5'-splice site (PubMed:9121479).

7227:Dmel CG1161
gene id: 7227:Dmel_CG1161
uniprot id: G4LU11
uniprot id: Q59E06
uniprot id: Q9VNA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM9 family.
messages: Membrane

7227:Dmel CG32199
gene id: 7227:Dmel_CG32199
uniprot id: Q9VVQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG8962
gene id: 7227:Dmel_CG8962
uniprot id: Q9VXP4
names: Caution
names: Similarity
names: Subunit
messages: Although strongly related to acetylglycerophosphocholine esterase enzymes, it lacks the active site and has no lipase activity.
messages: Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
messages: Does not interact with Lis-1.

7227:Dmel CG6056
gene id: 7227:Dmel_CG6056
uniprot id: Q9VDC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

7227:Dmel CG6024
gene id: 7227:Dmel_CG6024
uniprot id: Q5BIG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG6132
gene id: 7227:Dmel_CG6132
uniprot id: P02842
names: Developmental Stage
messages: Produced by third-instar larvae.

7227:Dmel CG3540
gene id: 7227:Dmel_CG3540
uniprot id: B6IDZ7
uniprot id: M9PGI4
uniprot id: O46051
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG13924
gene id: 7227:Dmel_CG13924
uniprot id: M9MRP4
uniprot id: Q9W072
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

7227:Dmel CG5946
gene id: 7227:Dmel_CG5946
uniprot id: E1JHY0
uniprot id: Q0E8F4
uniprot id: Q0E8F5
uniprot id: Q4LDP7
uniprot id: Q9I7R1
uniprot id: X2JGK6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

7227:Dmel CG8422
gene id: 7227:Dmel_CG8422
uniprot id: A1Z9Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG7625
gene id: 7227:Dmel_CG7625
uniprot id: Q9VP18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7227:Dmel CG9874
gene id: 7227:Dmel_CG9874
uniprot id: P20227
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus

7227:Dmel CG11753
gene id: 7227:Dmel_CG11753
uniprot id: A0A0B4KFH6
uniprot id: Q9VHP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Involved in protein trafficking.
messages: Membrane

7227:Dmel CG7962
gene id: 7227:Dmel_CG7962
uniprot id: P56079
uniprot id: X2JC55
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715). Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243).
messages: Endoplasmic reticulum membrane
messages: In 3rd instar larvae, expressed in various tissues including the brain, salivary glands, fat body, proventriculus, hind gut, muscle, Malpighian tubules and tracheal tubes. Relatively low levels of expression in the brain compared to expression levels in the salivary gland, fat body and gut.
messages: Lethal during the late embryonic to early larval stages (PubMed:24603715). Hypomorphic mutants are viable but male adults are sterile, whereas female adults remain fertile (PubMed:26791243). Impairs spermatid individualization showing abnormal mitochondria morphology and defects in lipid compositions and lipid-mediated signaling (PubMed:26791243). RNAi-mediated knockdown results in low insulin pathway activity and defective cell growth in certain tissues (PubMed:24603715). Various non-adipose tissues display excessive fat accumulation such as the salivary glands, proventriculus, hind gut, Malpighian tubules and trachea (PubMed:24603715). In addition gross reduction in cell size results in smaller salivary glands, imaginal disks and brains compared to controls (PubMed:24603715). RNAi-mediated knockdown in both the salivary glands and fat body, results in decreased levels of phosphatidylinositol (PtdIns) in the whole larvae and in the salivary glands (PubMed:24603715). Whole larvae also display decreased levels of phosphatidylglycerol (PG) and increased levels of phosphatidic acid (PA) (PubMed:24603715). Larvae display low insulin pathway activity with reduced levels of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) and phosphatidylinositol 3,4,5-trisphosphate (Ptdinsp3), and decreased levels of 'S-505' phosphorylated Akt1 (PubMed:24603715). RNAi-mediated knockdown specifically in the fat body, results in a decrease in PtdIns levels but there is no effect on the growth and neutral lipid storage in the fat body (PubMed:24603715). This is likely due to unknown compensatory mechanisms as there is an increase in the levels of diphosphate diacylglycerol and phosphatidylethanolamine in the fat body (PubMed:24603715).
messages: Membrane
messages: Retina. Localized to the photoreceptor neurons, both in the compound eyes and ocelli.

7227:Dmel CG7532
gene id: 7227:Dmel_CG7532
uniprot id: Q9V3Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect defense protein family.
messages: May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response.
messages: Secreted

7227:Dmel CG10901
gene id: 7227:Dmel_CG10901
uniprot id: P25158
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: Begins to accumulate at the posterior pole of the oocyte from stage 8 onwards.
messages: Capu, spir, and stau are required for the initial localization of osk to the posterior pole.
messages: Interacts with smaug (smg).
messages: Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.

7227:Dmel CG1216
gene id: 7227:Dmel_CG1216
uniprot id: Q0E8K5
uniprot id: X2J8G3
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG5734
gene id: 7227:Dmel_CG5734
uniprot id: Q9VL28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

7227:Dmel CG12372
gene id: 7227:Dmel_CG12372
uniprot id: A0A1B2AL22
uniprot id: Q9TVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity).
messages: Interacts with Spt5 to form DSIF. DSIF interacts with TRX, RNA polymerase II and with the FACT complex, which is composed of DRE4/SPT16 and SSRP/SSRP1. DSIF can also interact with the exosome, a complex with 3'-5' exoribonuclease activity which is composed of at least Csl4, Dis3, Mtr3, Rrp4, Rrp6, Rrp40, Rrp42, Rrp46 and Ski6. DSIF may also interact with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of Cdk9 and cyclin-T (CycT).
messages: Nucleus

7227:Dmel CG10255
gene id: 7227:Dmel_CG10255
uniprot id: Q9V780
names: Function
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.
messages: May have a role in assembling adherens junctions.

7227:Dmel CG12813
gene id: 7227:Dmel_CG12813
uniprot id: Q9VH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

7227:Dmel CG3622
gene id: 7227:Dmel_CG3622
uniprot id: Q9W1Z6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG5106
gene id: 7227:Dmel_CG5106
uniprot id: Q8T3W8
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG6072
gene id: 7227:Dmel_CG6072
uniprot id: A0A0B4LHI3
uniprot id: Q9XZL8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the RCAN family.
messages: Expressed both maternally and zygotically.
messages: Expressed in central nervous system of the third instar larvae, with a relatively intense signal in the brain and weak signals in the ventral ganglion. Relatively low, but ubiquitous expression level is observed in leg and wing imaginal disks, no signal is detected in the eye-antennal disks. Expressed in all neurons in the adult brain.
messages: Flies exhibit spontaneous ovulation in virgins, female sterility with impaired meiotic progression (eggs are arrested at anaphase of meiosis I, they fail to fully polyadenylate and translate bicoid mRNA and the male pronucleus fails to mature), and compromised postmating responses with lower ovulation level, higher remating rate, and shorter period for restoration of receptivity.
messages: Interacts with Pp2B-14D, CanA-14F and CanB2.
messages: Phosphorylation at Ser-215 and Ser-219 is essential for calcineurin activation and completion of female meiosis. Sgg is required for phosphorylation of Ser-215 in activated eggs. Ser-100, Thr-102 and Ser-219 are highly phosphorylated in both ovaries and activated eggs; however, phosphorylation at Ser-100 or Thr-102 is not required for sra function in completion of female meiosis.
messages: Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte.

7227:Dmel CG3279
gene id: 7227:Dmel_CG3279
uniprot id: Q9W0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

7227:Dmel CG31661
gene id: 7227:Dmel_CG31661
uniprot id: Q9VQ14
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG4700
gene id: 7227:Dmel_CG4700
uniprot id: Q24323
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Expression begins around stage 10 in weak epidermal stripes. Nervous system expression is first detected around stage 15 and at stage 16 appears to remain restricted to a small subset of neurons. Beginning around stage 14, it is also expressed at a very high level in a single ventral thoracic muscle fiber in segment T3. It is also expressed in the embryonic gonads and in anterior sensory organs, including the maxillary complex.
messages: Interacts with PlexB.
messages: Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.
messages: Secreted
messages: Transiently expressed by a single large muscle during motoneuron outgrowth and synapse formation.

7227:Dmel CG6986
gene id: 7227:Dmel_CG6986
uniprot id: Q9W4H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG31810
gene id: 7227:Dmel_CG31810
uniprot id: Q8SX47
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG11907
gene id: 7227:Dmel_CG11907
uniprot id: Q9VPP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7227:Dmel CG14870
gene id: 7227:Dmel_CG14870
uniprot id: Q9VF59
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the B9D family.
messages: Expressed in type I sensory neurons (at protein level) (PubMed:22508513, PubMed:30013109). Expressed in spermatids and spermatocytes (at protein level) (PubMed:25447994, PubMed:27646273, PubMed:27577095, PubMed:30013109).
messages: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273). Required for ciliary structure and function (PubMed:27577095).
messages: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
messages: Viable and fertile (PubMed:27577095). Results in lack of localization of the tectonic-like module proteins, namely MKS1 and B9d2, to the transition zone resulting in minor defects in sensory cilia (PubMed:27577095).
messages: cilium basal body

7227:Dmel CG13605
gene id: 7227:Dmel_CG13605
uniprot id: Q9VCD3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7127
gene id: 7227:Dmel_CG7127
uniprot id: H1UUN4
uniprot id: Q9VSJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation.
messages: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.

7227:Dmel CG3200
gene id: 7227:Dmel_CG3200
uniprot id: Q94915
names: Induction
messages: Maximally expressed at predawn or early morning.

7227:Dmel CG17988
gene id: 7227:Dmel_CG17988
uniprot id: Q8SXX2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG6106
gene id: 7227:Dmel_CG6106
uniprot id: Q9VWW1
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Homotetramer.

7227:Dmel CG7446
gene id: 7227:Dmel_CG7446
uniprot id: F3YDK8
uniprot id: Q24352
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
messages: Cell membrane
messages: GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with Lcch3 (beta chain).
messages: Membrane
messages: Postsynaptic cell membrane

7227:Dmel CG1977
gene id: 7227:Dmel_CG1977
uniprot id: M9PBI5
uniprot id: M9PDQ0
uniprot id: M9PGV6
uniprot id: P13395
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A substantial pool of maternal protein in the egg undergoes dynamic changes in distribution early in embryogenesis. In gastrulated embryo, the highest level of protein is found in the respiratory tract cells and the lowest in parts of the forming gut.
messages: Belongs to the spectrin family.
messages: Expressed both maternally and zygotically.
messages: Golgi apparatus
messages: Its transcript shares the first untranslated exon with the dlt transcript, suggesting a common regulation.
messages: Native spectrin molecule is a tetramer composed of two antiparallel heterodimers joined head to head so that each end of the native molecule includes the C-terminus of the alpha subunit and the N-terminus of the beta subunit. Interacts with calmodulin in a calcium-dependent manner, interacts with F-actin and also interacts with Lva. Interacts with Ten-m.
messages: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.
messages: cytoskeleton

7227:Dmel CG14804
gene id: 7227:Dmel_CG14804
uniprot id: Q9W552
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulation of wg in the Golgi, preventing wg from being secreted from the cells.
messages: Belongs to the VPS26 family.
messages: Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis.
messages: Component of the retromer complex, composed of Vps26 and Vps35.
messages: Cytoplasm
messages: Membrane

7227:Dmel CG6058
gene id: 7227:Dmel_CG6058
uniprot id: A4V3G1
uniprot id: C8VV14
uniprot id: F3YDE2
uniprot id: P07764
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer.
messages: Isozyme gamma is first detected during late embryogenesis, is present through larval stages, declines in abundance during pupal stages and is maximum at eclosion. Isozyme beta is abundant during the earliest stages of embryogenesis, declines in amount and increases prior to hatching. Isozyme alpha is found only during the adult stage. Expression correlates to dietary behavior: high dietary activity in the larvae and adults causes active glycolysis and high expression levels. Isozyme alpha-beta is detected in the pupae and adults and isozyme beta-gamma in the adult.
messages: Isozyme gamma is mainly expressed in the heads and partly in the thoraxes of adult flies. Isozyme alpha is expressed in all adult tissues. Isozyme beta is mainly expressed in adult abdominal regions and is also expressed in lesser amounts in other parts of the body and in earlier developmental stages. Isozyme alpha-beta shows strong expression in the abdomens of adults. Isozyme beta-gamma is expressed in adult heads.
messages: May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).

7227:Dmel CG5670
gene id: 7227:Dmel_CG5670
uniprot id: A0A0B4KGG8
uniprot id: B5RIT8
uniprot id: E1JIR4
uniprot id: H9ZJM5
uniprot id: P13607
names: Caution
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: High levels are found in some adult tissues: Malpighian tubules, indirect flight muscles, tubular leg muscles and throughout the nervous system (brain, optic lobes, retina and ventral thoracic neuromere). Lower levels are detected at the posterior end where the reproductive organs and rectum are located.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ouabain-sensitive electrogenic ion pump.
messages: Partially edited. Target of Adar.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

7227:Dmel CG4095
gene id: 7227:Dmel_CG4095
uniprot id: Q9W3X5
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

7227:Dmel CG1591
gene id: 7227:Dmel_CG1591
uniprot id: Q9V3P3
names: Similarity
messages: Belongs to the PA28 family.

7227:Dmel CG31240
gene id: 7227:Dmel_CG31240
uniprot id: Q7KSE4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7048
gene id: 7227:Dmel_CG7048
uniprot id: E1JIT4
uniprot id: Q9VCZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7227:Dmel CG11552
gene id: 7227:Dmel_CG11552
uniprot id: Q9VUJ4
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

7227:Dmel CG12161
gene id: 7227:Dmel_CG12161
uniprot id: Q8T915
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG1915
gene id: 7227:Dmel_CG1915
uniprot id: M9PBI9
uniprot id: M9PBJ0
uniprot id: M9PDS3
uniprot id: M9PDS8
uniprot id: M9PDZ6
uniprot id: M9PDZ9
uniprot id: M9PEA0
uniprot id: M9PEA5
uniprot id: M9PEA9
uniprot id: M9PGY4
uniprot id: M9PGZ0
uniprot id: Q9I7U4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed both maternally and zygotically (PubMed:11062264). Expressed throughout larval, pupal and adult stages (PubMed:22467859).
messages: Expressed in the mesoderm at stage 11, several hours before myoblast fusion, and persists in most muscle cells, somatic, visceral and pharyngeal muscles and their precursors, until the third instar (PubMed:10629221, PubMed:10934048, PubMed:9548712, PubMed:10669599, PubMed:8335002, PubMed:11062264). Isoform A: Expressed in the indirect flight muscle (at protein level) (PubMed:8335002, PubMed:22467859, PubMed:26251439).
messages: Flies exhibit chromosome undercondensation, chromosome breakage, loss of diploidy, and premature sister chromatid separation. They also exhibit defects in myoblast fusion, muscle organization and gut morphogenesis.
messages: Interacts with Msp300; this interaction mediates the recruitment of Msp300 to the Z-disks.
messages: Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
messages: Nucleus
messages: Z line

7227:Dmel CG4756
gene id: 7227:Dmel_CG4756
uniprot id: Q9VXB3
uniprot id: X2JKS9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAP30 family.
messages: Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle.
messages: Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC). Not essential for stability of the complex, recruitment of the complex to some promoters, or the deacetylase activity of the complex.
messages: Does not cause cell morphology changes, cell growth defects, cell cycle phenotypes, or loss of Smr/SMRTER protein from the Sin3A-histone deacetylase (HDAC1/Rpd3) complex.
messages: Nucleus

7227:Dmel CG4750
gene id: 7227:Dmel_CG4750
uniprot id: Q7K2S9
names: Similarity
messages: Belongs to the peptidase M17 family.

7227:Dmel CG32743
gene id: 7227:Dmel_CG32743
uniprot id: Q70PP2
uniprot id: X2JDZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors (PubMed:15965240) it may not be directly involved in NMD, as mutants do not abolish NMD. However, other data clearly show its involvement in NMD (PubMed:12881430 and PubMed:16199763).
messages: Belongs to the PI3/PI4-kinase family.
messages: Component of a post-splicing multiprotein NMD complex.
messages: Cytoplasm
messages: Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1.

7227:Dmel CG6146
gene id: 7227:Dmel_CG6146
uniprot id: M9NDX3
uniprot id: P30189
uniprot id: Q494M1
uniprot id: Q8IR39
uniprot id: X2JKD2
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type IB topoisomerase family.
messages: Cytoplasm
messages: Detected in germline and follicle cells. Expressed in follicle cells throughout oogenesis. In germline cells, expression levels increase as cells develop and move to the posterior region of the germarium, then at stage 5 of egg chamber development levels decrease until it is no longer detected (at protein level).
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Interacts with Topors.
messages: Nucleus
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils (By similarity). Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

7227:Dmel CG6042
gene id: 7227:Dmel_CG6042
uniprot id: Q9VE00
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Bari1 transposable element insertion in the 3' end of the gene leads to ten-fold more abundant expression than in flies lacking the insert.
messages: Belongs to the cytochrome P450 family.
messages: Expression in third-instar larvae is detected in the midgut and Malpighian tubules of both lufenuron-resistant and wild-type strains, higher expression level is seen in lufenuron-resistant strains.
messages: Has a role in resistance to insecticide lufenuron, but no other insecticides.
messages: Mitochondrion membrane

7227:Dmel CG4225
gene id: 7227:Dmel_CG4225
uniprot id: Q9VF20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

7227:Dmel CG2530
gene id: 7227:Dmel_CG2530
uniprot id: P41046
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Essential protein required for proper condensation of mitotic chromosomes and progression through mitosis (PubMed:9463384). Binds to specific polytene chromosome sites, many of which are shared with the posterior sex combs (Psc) protein (PubMed:9463384). Involved in maintaining Abd-B repression outside its normal expression domain (PubMed:18667003, PubMed:18286205).
messages: Expressed during oogenesis, embryonic and larval stages.
messages: Homodimer (PubMed:12771214). Interacts with esc, Trl, E(z), scm and ph-p in vitro (PubMed:12771214). Found in vivo in an esc-containing complex, which may be the Esc/E(z) complex (PubMed:12771214). Also found in vivo in a Pc-containing complex that may be the PRC1 complex, but does not interact with Pc directly (PubMed:12771214). Interacts with cyclin CycG (PubMed:18286205).
messages: Nucleus
messages: centrosome

7227:Dmel CG32736
gene id: 7227:Dmel_CG32736
uniprot id: Q9W3T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM4 family.
messages: Membrane

7227:Dmel CG5942
gene id: 7227:Dmel_CG5942
uniprot id: M9PFM5
uniprot id: M9PFS6
uniprot id: P25439
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: 'Brahma' means 'fate' in India.
messages: Component of the Brahma complex, which is composed of brm, osa, mor, Snr1/Bap45, dalao/Bap111, Bap55, Bap60 and Act42A/Bap47 (PubMed:10601025, PubMed:10809665). Interacts with asf1 (PubMed:12381660). Associates with the brm-HDAC3-erm repressor complex, composed of brm, HDAC3 and erm (PubMed:24618901). Interacts with erm and HDAC3 (PubMed:24618901).
messages: Highest expression in unfertilized eggs and early embryos.
messages: Nucleus
messages: RNAi-mediated knockdown in larval brains results in the formation of ectopic neuroblasts in type II neuroblast lineage. Simultaneous RNAi-mediated knockdown of HDAC3 or erm in type II neuroblasts results in a more severe phenotype of ectopic neuroblasts.
messages: Transcriptional regulator (PubMed:1346755). Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters (PubMed:1346755). Can counteract the repressive effect of Polycomb protein (PubMed:1346755). ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA (PubMed:1346755). This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (PubMed:10809665). In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3 (PubMed:24618901).

7227:Dmel CG1065
gene id: 7227:Dmel_CG1065
uniprot id: Q94522
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
messages: Viable (PubMed:28017724). During development, results in delayed egg eclosion, reduced glycogen levels and extension of the third instar larval period but without change of the duration of the pupal period or final size of organ (PubMed:28017724). In the adult, results in defects in locomotor activity (PubMed:28017724). Results in disregulation of both glycolysis and the citric acid cycle (TCA) including accumulation of Succinyl-CoA and succinate, and reduction of GABA (PubMed:28017724).

7227:Dmel CG17957
gene id: 7227:Dmel_CG17957
uniprot id: P07666
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
messages: Transcript levels rise steadily during syncytial stages to reach a peak in early cycle 14 and then decline rapidly during cellularization.
messages: Transient expression in blastoderm from nuclear cycle 11 to the onset of gastrulation.

7227:Dmel CG10992
gene id: 7227:Dmel_CG10992
uniprot id: Q9VY87
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG4535
gene id: 7227:Dmel_CG4535
uniprot id: Q9VL78
names: Developmental Stage
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically. First expressed at a high level in 0-2 hours embryos. Expression then gradually increases through the end of embryogenesis and laval development. Detected at lower levels in third-instar larvae and pupal stages. Expressed at a high level in adult females and at a lower level in adult males.
messages: Expression in the embryo is limited to three tissues: lymph glands, Garland cells and oenocyte cells.
messages: Interacts with inaD and trpl, and may be part of the inaD signaling complex.
messages: May have a role in phototransduction; inhibits or prevents Ca(2+) induced stimulation of the trpl ion channel.

7227:Dmel CG5322
gene id: 7227:Dmel_CG5322
uniprot id: Q9VKV2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG6724
gene id: 7227:Dmel_CG6724
uniprot id: M9PB96
uniprot id: Q9VKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

7227:Dmel CG2262
gene id: 7227:Dmel_CG2262
uniprot id: O96660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG8639
gene id: 7227:Dmel_CG8639
uniprot id: A0A0B4K6T3
uniprot id: A0A0B4K7U8
uniprot id: A0A0B4KEF5
uniprot id: A0A0B4KEG9
uniprot id: A1Z7G7
uniprot id: E1JH11
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
messages: Membrane
messages: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

7227:Dmel CG2668
gene id: 7227:Dmel_CG2668
uniprot id: Q9U6L5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Major protein component of the posterior mating plug. Accessory gland proteins constitute, or are required for formation of the anterior mating plug. Posterior mating plug forms before sperm transfer and the anterior mating plug is formed after the start of mating.
messages: Secreted
messages: Specifically expressed in the ejaculatory bulb and seminal fluid. Detected in mated females 3 minutes after the start of mating, and for at least 3 hours after the start of mating.

7227:Dmel CG6226
gene id: 7227:Dmel_CG6226
uniprot id: P54397
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FKBP-type PPIase family.
messages: Expressed during all stages of development with highest expression in early embryo.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development.
messages: Ubiquitously expressed, highest levels in ovary.

7227:Dmel CG5210
gene id: 7227:Dmel_CG5210
uniprot id: A0A0B4LFJ1
uniprot id: Q23997
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
messages: Expressed throughout development and in adults.
messages: Glycosylated.
messages: In larvae, it is expressed in the fat body and by hemocytes.
messages: Lacks the typical Glu active site in position 165 that is replaced by a Gln residue, exhibits no chitinolytic activity towards either polymeric and oligomeric substrates. Its precise function remains unclear.
messages: Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
messages: Secreted

7227:Dmel CG42347
gene id: 7227:Dmel_CG42347
uniprot id: Q95SK9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG4316
gene id: 7227:Dmel_CG4316
uniprot id: Q05319
names: Caution
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: By 20-hydroxyecdysone (20HE).
messages: Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis.
messages: It is uncertain whether Met-1 or Met-24 is the initiator.
messages: May activate itself by proteolytic cleavage.
messages: Membrane

7227:Dmel CG4107
gene id: 7227:Dmel_CG4107
uniprot id: Q9VTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

7227:Dmel CG32443
gene id: 7227:Dmel_CG32443
uniprot id: P26017
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, HDAC1/Rpd3 and Caf1-55. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (PubMed:11493925, PubMed:11583617). Interacts with stx; the interaction targets Pc for ubiquitin-independent proteasomal degradation (PubMed:27326929). Interacts with Nup93-1 (PubMed:31784359).
messages: Nucleus
messages: Polycomb group (PcG) protein (PubMed:1898775). PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (PubMed:1898775, PubMed:11493925, PubMed:11583617). PcG proteins are not required to initiate repression, but to maintain it during later stages of development (PubMed:1898775). Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility (PubMed:11493925, PubMed:11583617). Promotes locus-specific chromatin compaction (PubMed:11493925, PubMed:11583617). Binds to (N(6)-methyladenosine) DNA and thereby might implement repression of specific loci (PubMed:30078725).
messages: Required during the entire larval period for normal adult development. It is found in almost all cells and tissues throughout gastrulation and organogenesis though at a much lower level than in early syncytial stages.

7227:Dmel CG10726
gene id: 7227:Dmel_CG10726
uniprot id: Q9VIP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

7227:Dmel CG4785
gene id: 7227:Dmel_CG4785
uniprot id: Q9VPY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INTS14 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5.
messages: Nucleus

7227:Dmel CG3695
gene id: 7227:Dmel_CG3695
uniprot id: Q9W1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex (By similarity). Interacts with Hsf.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcriptional activation in response to heat shock.
messages: Nucleus

7227:Dmel CG6293
gene id: 7227:Dmel_CG6293
uniprot id: Q9VH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

7227:Dmel CG33886
gene id: 7227:Dmel_CG33886
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG1287
gene id: 7227:Dmel_CG1287
uniprot id: Q9VIB2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7367
gene id: 7227:Dmel_CG7367
uniprot id: Q4V6L0
uniprot id: Q9VLU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG18108
gene id: 7227:Dmel_CG18108
uniprot id: P82706
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bomanin family.
messages: By bacterial infection.
messages: Hemolymph (at protein level).
messages: Secreted
messages: Secreted immune-induced peptide induced by Toll signaling (PubMed:9736738, PubMed:25915418, PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:9736738, PubMed:25915418, PubMed:29920489). Has no activity against the fungus C.glabrata in vitro (PubMed:29920489).

7227:Dmel CG31390
gene id: 7227:Dmel_CG31390
uniprot id: Q9GYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex (By similarity). Interacts with MED21.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Nucleus

7227:Dmel CG3252
gene id: 7227:Dmel_CG3252
uniprot id: C7LA87
uniprot id: Q9W4C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: In larvae, weak specific expression in the anterior midgut just proximal to the gastric caeca reproductive rudiments, common ureters of the Malpighian tubules, and distal swollen portion of the anterior pair of Malpighian tubules. Expression is also seen in the imaginal disks of the head; brain hemispheres and the ventral ganglion. Stronger expression in the posterior midgut.
messages: Membrane
messages: Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.

7227:Dmel CG4852
gene id: 7227:Dmel_CG4852
uniprot id: Q9U1H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.

7227:Dmel CG31061
gene id: 7227:Dmel_CG31061
uniprot id: Q8IMN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
messages: Cell membrane
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG9126
gene id: 7227:Dmel_CG9126
uniprot id: P83094
uniprot id: Q7KUZ1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores.

7227:Dmel CG4963
gene id: 7227:Dmel_CG4963
uniprot id: Q9VAY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.
messages: Mitochondrion inner membrane

7227:Dmel CG4633
gene id: 7227:Dmel_CG4633
uniprot id: Q9VRJ1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Mitochondrion
messages: Monomer.

7227:Dmel CG14286
gene id: 7227:Dmel_CG14286
uniprot id: Q9VE11
names: Similarity
messages: Belongs to the UPF0488 family.

7227:Dmel CG1916
gene id: 7227:Dmel_CG1916
uniprot id: A0A0B4LFY4
uniprot id: I0E2I5
uniprot id: P28465
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.
messages: Dynamic expression pattern during embryogenesis. Expression is predominantly segmented, with expression also seen in the limb primordia and presumptive gonads. In embryonic tracheal cells, expression is close to and dorsal to the tracheal placode.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylated by porcupine. The lipid group functions as a sorting signal, targeting the ligand to polarized vesicles that transport Wnt2 to unique sites at the cell surface. Depalmitoleoylated by notum, leading to inhibit Wnt signaling pathway.
messages: extracellular matrix

7227:Dmel CG12348
gene id: 7227:Dmel_CG12348
uniprot id: A0A0S0X7Z4
uniprot id: E1JJQ5
uniprot id: M9NGK2
uniprot id: M9PHG6
uniprot id: M9PJQ4
uniprot id: P08510
names: Disruption Phenotype
names: Domain
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Shaker sub-subfamily.
messages: Cell membrane
messages: Homotetramer or heterotetramer of potassium channel proteins.
messages: Membrane
messages: Partially edited.
messages: Reduced sleep (PubMed:15858564). Flies sleep for one-third of the wild-type amount (PubMed:15858564). They perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation (PubMed:15858564). They also have a reduced lifespan (PubMed:15858564). Males are able to discriminate between males and females during courtship but their courtship of females is reduced, suggesting that their perception and/or response to wild-type female pheromones is decreased (PubMed:22292044). RNAi-mediated knockdown in all neurons or specifically in the mushroom bodies of adult males, impairs their ability to discriminate between males and females (PubMed:22292044). However, knockdown in various chemosensory peripheral neurons has no effect on male sex discrimination (PubMed:22292044).
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636). Plays a role in the regulation of sleep need or efficiency (PubMed:15858564). Plays a role in sexual behavior, where it is important for male sex discrimination (PubMed:22292044).

7227:Dmel CG5179
gene id: 7227:Dmel_CG5179
uniprot id: O17432
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG8959
gene id: 7227:Dmel_CG8959
uniprot id: Q9VXP5
names: Subcellular Location Annotation
messages: cilium axoneme

7227:Dmel CG6417
gene id: 7227:Dmel_CG6417
uniprot id: Q9VK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Membrane

7227:Dmel CG10465
gene id: 7227:Dmel_CG10465
uniprot id: Q7JZ62
names: Similarity
messages: Belongs to the BACURD family.

7227:Dmel CG42637
gene id: 7227:Dmel_CG42637
uniprot id: A4V243
uniprot id: Q7JQ32
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abnormal patterning of the somatic body wall muscles with numerous ventral and lateral muscles that fail to extend or are missing and reduced levels of integrin beta-ps at dorsal muscle myotendinous junctions (PubMed:23213443). Defects in salivary gland invagination, migration and lumen shape and mislocalization of the integrin-binding protein rhea/Talin (PubMed:23862019). Defects in motor axon guidance with failure of motor axons to defasciculate from one another and innervate their proper muscle targets (PubMed:15282266). Wings display disrupted posterior crossveins (PubMed:26440503). RNAi-mediated knockdown in malpighian tubule principal cells inhibits NPLP1-4-mediated increases in fluid transport rates and cGMP levels, inhibits NPLP1-4-mediated nuclear translocation of NF-kappa-B protein Rel and abolishes expression of the antimicrobial peptide diptericin (PubMed:21893139).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in embryo, larva, pupa and adult (PubMed:7706258, PubMed:7759483). Expressed at very high levels in early cleavage stage embryos at 0-2 hours followed by lower expression at 2-6 and 6-10 hours of embryogenesis (PubMed:7706258). During later stages of embryogenesis at 10-14 and 14-18 hours, expressed again at high levels, particularly in muscle fibers (PubMed:7706258). Very low levels in larval and pupal stages (PubMed:7706258).
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagination, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kinase For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503).
messages: In the adult, widely distributed in the head and thorax with highest levels in the optic lobe and central brain and expression also detected in the retina (PubMed:7759483). Expressed at similar levels in adult head and body (PubMed:7759483). In females, highly expressed in oocytes with lower levels in the digestive tract (PubMed:7759483). In mid-embryogenesis, enriched in the circular visceral mesoderm that overlies the migrating salivary gland and in the fat body that underlies the gland but at background levels in the gland itself (PubMed:23213443). In late embryogenesis, detected in the mature salivary gland, in the somatic body wall muscles and the tendon cells to which the muscles attach, and in the constricting midgut (PubMed:23213443). Also expressed in migrating tracheal cells at mid-embryogenesis and in the developed trachea at the end of embryogenesis with enrichment in the apical domains (PubMed:23213443).
messages: Interacts with the semaphorin 1A receptor PlexA; PlexA enhances Gyc76C catalytic activity. Interacts with the PDZ domain-containing protein kermit; kermit increases cell surface expression of Gyc76C.
messages: Membrane
messages: The guanylate cyclase domain is required for Sema-1a-mediated axon repulsion.
messages: The protein kinase domain is predicted to be catalytically inactive.

7227:Dmel CG10092
gene id: 7227:Dmel_CG10092
uniprot id: Q8SXK2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG6022
gene id: 7227:Dmel_CG6022
uniprot id: Q9VD55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG10571
gene id: 7227:Dmel_CG10571
uniprot id: E1JHZ0
uniprot id: Q24248
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Araucan' is named after the Araucanian American-Indian tribe, also called Mohawks, who shaved all but a medial stripe of hairs on the head.
messages: Belongs to the TALE/IRO homeobox family.
messages: Controls proneural and vein forming genes. Positive transcriptional controler of AC-SC (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the AC and SC promoters and participates in transcription initiation.
messages: Nucleus

7227:Dmel CG1140
gene id: 7227:Dmel_CG1140
uniprot id: M9PGX7
uniprot id: Q9W058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Homodimer.
messages: Key enzyme for ketone body catabolism (PubMed:24100554). Transfers the CoA moiety from succinate to acetoacetate (PubMed:24100554). Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

7227:Dmel CG9903
gene id: 7227:Dmel_CG9903
uniprot id: Q9VXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

7227:Dmel CG41106
gene id: 7227:Dmel_CG41106
uniprot id: Q5LJU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

7227:Dmel CG1890
gene id: 7227:Dmel_CG1890
uniprot id: Q9V9U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

7227:Dmel CG7728
gene id: 7227:Dmel_CG7728
uniprot id: Q9VVC9
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG42273
gene id: 7227:Dmel_CG42273
uniprot id: P49657
uniprot id: Q9VX06
uniprot id: X2JFM3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Flies exhibit a specific and marked size reduction of the optic lobes and central brain hemispheres but no major alteration in neuronal architecture can be found.
messages: In ventral nerve cord and supraesophageal ganglion of embryos. Is most prominent in the mushroom body neuropil and the outer proliferation center of the optic lobes in third instar larvae.
messages: Isoform A and isoform C are present mainly in embryos and pupae. By contrast, isoform D appears to be expressed most markedly in third instar larvae and pupae.
messages: Nucleus
messages: Role in the specific control of proper proliferation of optic lobe neuronal progeny.

7227:Dmel CG3002
gene id: 7227:Dmel_CG3002
uniprot id: Q9W329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: trans-Golgi network membrane

7227:Dmel CG4713
gene id: 7227:Dmel_CG4713
uniprot id: M9NEZ0
uniprot id: Q9VKJ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CC2D1 family.
messages: Cytoplasm
messages: Expressed in wing and eye imaginal disks.
messages: Flies exhibit problems in vein, eye, and bristle development.
messages: Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling.

7227:Dmel CG7162
gene id: 7227:Dmel_CG7162
uniprot id: H8F4P0
uniprot id: M9PII7
uniprot id: Q9VP05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7227:Dmel CG2964
gene id: 7227:Dmel_CG2964
uniprot id: Q9VQH0
names: Similarity
messages: Belongs to the pyruvate kinase family.

7227:Dmel CG6153
gene id: 7227:Dmel_CG6153
uniprot id: E1JHG8
uniprot id: Q9VK68
names: Similarity
messages: Belongs to the PITHD1 family.

7227:Dmel CG12740
gene id: 7227:Dmel_CG12740
uniprot id: D1Z3A1
uniprot id: Q9VZS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

7227:Dmel CG13168
gene id: 7227:Dmel_CG13168
uniprot id: A0A0B4LG74
uniprot id: A1Z8V5
uniprot id: A1Z8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: flagellum axoneme

7227:Dmel CG11170
gene id: 7227:Dmel_CG11170
uniprot id: Q9W280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

7227:Dmel CG30423
gene id: 7227:Dmel_CG30423
uniprot id: Q8MMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

7227:Dmel CG17221
gene id: 7227:Dmel_CG17221
uniprot id: Q8IPZ3
uniprot id: Q9VQL4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

7227:Dmel CG3891
gene id: 7227:Dmel_CG3891
uniprot id: Q9VSY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

7227:Dmel CG8782
gene id: 7227:Dmel_CG8782
uniprot id: Q9VW26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homotetramer.
messages: Mitochondrion matrix

7227:Dmel CG8578
gene id: 7227:Dmel_CG8578
uniprot id: Q9VXN3
names: Similarity
messages: Belongs to the LRRFIP family.

7227:Dmel CG8046
gene id: 7227:Dmel_CG8046
uniprot id: A1Z7R6
uniprot id: A1Z7R7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7149
gene id: 7227:Dmel_CG7149
uniprot id: Q8T0S3
uniprot id: X2J9T3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7227:Dmel CG17853
gene id: 7227:Dmel_CG17853
uniprot id: D3DMX3
uniprot id: P81918
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 16 olfactory receptor neurons in a broad area across the antenna, including both anterior and posterior faces and in the maxillary palp. This expression pattern matches the distribution of the small sensilla basiconica. Expression in the antenna is observed late in antennal development at 93 hours APF.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG9890
gene id: 7227:Dmel_CG9890
uniprot id: Q9W1V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZNF277 family.
messages: Cytoplasm
messages: DNA binding protein which is involved in the positive regulation of both basal and inducible transcription (PubMed:33456983). Mainly localizes to active promoter sites and interacts with components of various transcription and replication regulatory complexes, such as the ORC, SAGA, THO, TFIID and SWI/SNF complexes (PubMed:30713769, PubMed:33456983). It may therefore regulate transcription by promoting the association of these complexes to their binding sites (PubMed:30713769, PubMed:33456983).
messages: Interacts with components of the origin recognition complex (ORC) complex, Orc2 and Orc3, components of the SAGA transcription coactivator-HAT complex, Gcn5 and e(y)2, components of the mRNP biogenesis THO complex, thoc5 and e(y)2, and a component of the TFIID complex, TBP (PubMed:30713769). Also interacts with polybromo, a component of the chromatin remodeling SWI/SNF complex (PubMed:30713769).
messages: Nucleus

7227:Dmel CG44152
gene id: 7227:Dmel_CG44152
uniprot id: Q9VL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG15730
gene id: 7227:Dmel_CG15730
uniprot id: Q9VYM3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in chordotonal neurons in the antennae (at protein level) (PubMed:27646273). Expressed in spermatids (at protein level) (PubMed:27646273, PubMed:25447994, PubMed:27577095).
messages: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273). Required for ciliary structure and function (PubMed:27577095).
messages: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
messages: Viable and fertile. Minor defects in sensory cilia function probably due to lack of localization of the tectonic-like module proteins, namely tcnt, B9d1, B9d2 and TMEM216, to the transition zone. Does not affect the recruitment of Cep290 (PubMed:27577095). In sensory cells associated with the notum hair socket, results in structural defects including axonemes with abnormal microtubule connections to the basal body (BB); results in subtle defects in the localization of intraflagellar transport (IFT) proteins and an increase in the ratio of cilium volume to inner membrane volume (PubMed:27577095).
messages: centriole
messages: cilium basal body

7227:Dmel CG9212
gene id: 7227:Dmel_CG9212
uniprot id: M9PJP0
uniprot id: Q9VXK0
names: Similarity
messages: Belongs to the NipSnap family.

7227:Dmel CG11720
gene id: 7227:Dmel_CG11720
uniprot id: P02840
names: Developmental Stage
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In the salivary glands of mid instar larvae levels dramatically increase during puff stage 1 at 98-106 hours of development. Levels remain constant and abundant in late larvae until puff stage 10, then decrease by stage 11.
messages: O-glycosylated by Pgnat9 in salivary glands.
messages: Secreted
messages: Specifically expressed in the salivary gland.

7227:Dmel CG31202
gene id: 7227:Dmel_CG31202
uniprot id: Q8IMK0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7227:Dmel CG6816
gene id: 7227:Dmel_CG6816
uniprot id: Q95078
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: By 20-hydroxyecdysone during the three larval stages, at pupariation and in pupae.
messages: Endoplasmic reticulum membrane
messages: Expressed in body wall (epidermal and muscle cells) and mid- and hind-gut.
messages: Low levels throughout postembryonic development.
messages: Microsome membrane
messages: Probably involved in steroid hormones biosynthesis.

7227:Dmel CG17945
gene id: 7227:Dmel_CG17945
uniprot id: Q01644
names: Developmental Stage
names: Domain
names: Similarity
names: Tissue Specificity
messages: Belongs to the MST(3)CGP family.
messages: Primary spermatocytes.
messages: Testis.
messages: This protein is mostly composed of repetitive C-G-P motifs.

7227:Dmel CG10079
gene id: 7227:Dmel_CG10079
uniprot id: P04412
uniprot id: Q8MLW0
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Embryonic wound healing defects. RNAi-mediated knockdown in tracheal cells results in defective gas-filling lumen in terminal branches (PubMed:23029159).
messages: Homodimer (PubMed:19718021, PubMed:20723758). Binding of the ligand spitz triggers homodimerization of the receptor however, it is able to form dimers, albeit weakly, in the absence of spitz (PubMed:19718021, PubMed:20723758). Interacts (when phosphorylated on tyrosine residues) with Vav (via SH2 domain) (PubMed:10781813). Interacts (when ubiquitinated) with Graf (PubMed:28993397). May interact (when phosphorylated) with EGFRAP (via SH2 domain) (PubMed:34411095).
messages: Membrane
messages: Receptor tyrosine kinase, binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8070664, PubMed:9882502, PubMed:22140578, PubMed:23579691). Known ligands include spitz, gurken, vein and giant-lens (PubMed:9882502, PubMed:22140578, PubMed:19718021, PubMed:20723758). Transduces the signal through the ras-raf-MAPK pathway (PubMed:9094709). Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte (PubMed:9882502, PubMed:23579691, PubMed:34411095). In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system, and production and repair of the cuticle (PubMed:22140578, PubMed:23579691, PubMed:9094709, PubMed:23029159). During dorsal closure (DC) functions with the dpp- and ACK-signaling pathways to regulate expression of the myosin zip in the embryonic epidermis and amnioserosa (AS), and thus coordinate the progression of epidermal cell shape changes required for correct DC (PubMed:23579691). In the embryonic epidermis, functions by negatively regulating dpp and consequently the dpp-dependent expression of the myosin zip (PubMed:23579691). In the AS, negatively regulates the production/ and or secretion of a diffusible signal which, is produced by the ACK-signaling pathway, and acts in the AS and epidermal cells to promote zip expression (PubMed:23579691). Also required in the AS to inhibit or delay apoptosis, and consequently slow the rate of DC (PubMed:23579691). Therefore functions at multiple levels to negatively regulate morphogenesis during DC, suggesting that it acts as a general brake mechanism for adjusting the rate of dorsal closure to ensure that closure proceeds smoothly and without loss of epidermal integrity (PubMed:23579691). …
messages: Ubiquitination by Cbl in response to high spi, promotes its interaction with Graf and thus facilitates its GPI-enriched endocytic compartment (GEEC) mediated endocytosis and its subsequent degradation.
messages: Ubiquitously expressed in embryos. In larvae, uniform expression is seen in wing disks, genital disk, anlagen of testis and ovary, and brain cortex. In eye-antenna disk, highest expression is anterior to morphogenetic furrow, levels remain high in photoreceptor precursor cells. This pattern is reversed in posterior eye disk. In adults expression is high in brain cortex and thoracic and abdominal ganglia.

7227:Dmel CG12008
gene id: 7227:Dmel_CG12008
uniprot id: A8JNJ6
uniprot id: M9PBL6
uniprot id: Q7KV69
uniprot id: Q7KV70
uniprot id: Q9VZQ3
names: Similarity
messages: Belongs to the spectrin family.

7227:Dmel CG1333
gene id: 7227:Dmel_CG1333
uniprot id: Q9V3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: May function both as a monomer and a homodimer.
messages: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).

7227:Dmel CG4314
gene id: 7227:Dmel_CG4314
uniprot id: P45843
uniprot id: S5M3P7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters and metabolic intermediates (PubMed:812484, PubMed:18931318, PubMed:33820991). In the eye and probably in association with w/white, required for the transport of the eye brown pigment precursors, kynurenine and probably tryptophan, into pigment cell granules (PubMed:812484, PubMed:10407069). In Malpighian tubules and pupal eyes, involved in kynurenine transport (PubMed:812484). Probably in association with w/white, plays a role in zinc storage granule biogenesis in Malpighian tubule principal epithelial cells (PubMed:29367274).
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cytoplasmic vesicle membrane
messages: Expressed in early and late larvae, in pupae and, to a lesser extent, in adults.
messages: Expressed in the eye, specifically in primary pigment cells, secondary pigment cells and retinula cells (at protein level).
messages: Eyes are scarlet due to a defect in brown pigment production (PubMed:10407069). In larval Malpighian tubules and pupal eyes, kynurenine uptake is impaired resulting in a severe decrease in 3-hydroxykynurenine production (PubMed:812484). In the head, levels of neurotransmitters histamine, dopamine and serotonin are reduced (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, numbers of synaptic vesicles and capitate projections, which are sites of endocytosis of vesicle membrane, are reduced (PubMed:18931318). Reduces the levels of several metabolites, including tryptophan, kynurenine, 3-hydroxykynurenine, guanosine, and, to a lesser extent, xanthine and riboflavin, and increases the levels of guanine and tetrahydrofolate (PubMed:33820991). 3-fold reduction in Malpighian tubule zinc stores (PubMed:29367274).
messages: May form a heterodimer with w/white.
messages: Membrane

7227:Dmel CG31695
gene id: 7227:Dmel_CG31695
uniprot id: P54631
uniprot id: X2JB15
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Expressed both maternally and zygotically. Highest embryonic expression is found during syncytial blastoderm (nuclear cycles 11-12). Expression declines rapidly at cellular blastoderm stage 5 and is not detected during the rest of embryonic development.
messages: Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.
messages: Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.
messages: Secreted
messages: Ubiquitously expressed during early stages of embryogenesis, but the effect on development appears graded and is restricted to the dorsal side of the embryo.

7227:Dmel CG7776
gene id: 7227:Dmel_CG7776
uniprot id: A0A0B4KEK1
uniprot id: A0A0B4KET9
uniprot id: A0A0B4KFP2
uniprot id: Q0E9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

7227:Dmel CG34369
gene id: 7227:Dmel_CG34369
uniprot id: A0A0B4LG42
uniprot id: Q9W2B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG31045
gene id: 7227:Dmel_CG31045
uniprot id: Q0KI66
uniprot id: Q0KI67
uniprot id: Q8IH49
uniprot id: Q8INC3
uniprot id: Q9VEZ0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG10619
gene id: 7227:Dmel_CG10619
uniprot id: Q9VJ37
uniprot id: Q9Y0Z9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8975
gene id: 7227:Dmel_CG8975
uniprot id: P48592
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm
messages: Heterodimer of a large and a small subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

7227:Dmel CG5032
gene id: 7227:Dmel_CG5032
uniprot id: Q9UAS6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Ganglionic branches migrate normally along the intersegmental nerve, but sporadically fail to switch to the segmental nerve and enter the CNS; they wind up meandering along the ventral epidermis instead.
messages: Induced by the branchless FGF pathway in migrating tracheal cells, resulting of the switch from the intersegmental to the segmental nerve.
messages: Maternally expressed and distributed during the syncytial blastoderm stage. In zygote first detected in mid-embryogenesis in the developing tracheal system and later in the developing gonad. Tracheal expression is highly dynamic. At stage 11, weakly expressed in all tracheal cells. During stages 12 and 13, preferential expression in the leading cells of the ganglionic branch and other growing primary branches. During stages 14 and 15, expression becomes further restricted to just the GB1 terminal cell and other terminal cells.
messages: Nucleus
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve (PubMed:10068643).

7227:Dmel CG33868
gene id: 7227:Dmel_CG33868
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG17927
gene id: 7227:Dmel_CG17927
uniprot id: A0A0S0WIH4
uniprot id: E1JHJ3
uniprot id: E1JHJ4
uniprot id: E1JHJ5
uniprot id: M9NCU7
uniprot id: M9ND95
uniprot id: M9NEP1
uniprot id: M9NF46
uniprot id: P05661
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternative splicing exons contribute to the specialized contractile activities of different muscle types. Exon 3 encodes the hydrophobic pocket adjacent to the ATP-binding site, exon 9 is adjacent to the actin-binding domain, exon 11 is involved in actin-binding, exon 15 in the S2 hinge and exons 18 and 19 the non-coiled tail region.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Expressed in larval and adult muscles. Isoforms containing exon 9a are expressed in indirect flight muscles, exons 9a and 9b are expressed in jump muscles, exons 9b and 9c are expressed in other larval and adult muscles.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: myofibril

7227:Dmel CG7938
gene id: 7227:Dmel_CG7938
uniprot id: P07665
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds chromatin; requires N-terminal regions to form protein-protein contacts, in addition to DNA specific recognition by the zinc fingers.
messages: Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'.
messages: Expressed both maternally and zygotically. Abundant in early embryos and present in very low amounts at every stage of the life-cycle.
messages: Nucleus

7227:Dmel CG15581
gene id: 7227:Dmel_CG15581
uniprot id: Q9VNK9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or67d subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG1523
gene id: 7227:Dmel_CG1523
uniprot id: Q9VAT2
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.

7227:Dmel CG1725
gene id: 7227:Dmel_CG1725
uniprot id: P31007
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Contains the N-terminal domain essential for correct neuronal development.
messages: Cytoplasm
messages: During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
messages: During the cellular blastoderm stage, isoform B, isoform F, isoform H, isoform I and isoform L expression is localized to the cell borders. From stage 11 onwards, expression is found predominantly in the developing nervous system: axon bundles in the ventral cord and the brain. Stage 14 and 15 embryos exhibit expression in the developing body wall muscle. Expression in neuropil regions of the CNS and at NMJs persists through to larval development. Other isoforms show expression in embryonic epithelial cells. In larvae, expression is seen as a belt around salivary glands, imaginal disks and proventriculus. Expressed in adult reproductive tissues. In epithelia, coexpressed with scrib throughout development.
messages: Expressed both maternally and zygotically throughout development.
messages: cytoskeleton
messages: septate junction

7227:Dmel CG14900
gene id: 7227:Dmel_CG14900
uniprot id: Q9VEU1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

7227:Dmel CG11246
gene id: 7227:Dmel_CG11246
uniprot id: Q9VNZ3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

7227:Dmel CG6330
gene id: 7227:Dmel_CG6330
uniprot id: Q8IMQ8
uniprot id: Q9VBA0
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

7227:Dmel CG17250
gene id: 7227:Dmel_CG17250
uniprot id: Q9V9I2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol, ethyl acetate, propyl acetate, and pentyl acetate. Responds also to pyrazines.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG8581
gene id: 7227:Dmel_CG8581
uniprot id: A0A0B4LEX6
uniprot id: A1Z920
uniprot id: A1Z921
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

7227:Dmel CG3635
gene id: 7227:Dmel_CG3635
uniprot id: M9NFE4
uniprot id: Q9V9N3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG11077
gene id: 7227:Dmel_CG11077
uniprot id: Q9V492
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Involved in mitochondria homeostasis.
messages: Mitochondrion inner membrane

7227:Dmel CG1515
gene id: 7227:Dmel_CG1515
uniprot id: Q9W3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

7227:Dmel CG4697
gene id: 7227:Dmel_CG4697
uniprot id: Q9VJR9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG8945
gene id: 7227:Dmel_CG8945
uniprot id: Q9VX86
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG6148
gene id: 7227:Dmel_CG6148
uniprot id: Q8T6I0
uniprot id: Q8T8W3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

7227:Dmel CG4475
gene id: 7227:Dmel_CG4475
uniprot id: D4G7B1
uniprot id: Q9V3D4
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
messages: Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.
messages: Expressed both maternally and zygotically. Expressed throughout development, with a much stronger expression during larval stages.
messages: Glycosylated.
messages: Lacks the typical Glu active site in position 152 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.
messages: Primarily expressed in yolk cells and fat body. In larvae, it is expressed in the imaginal ring and weakly expressed in imaginal disks. More strongly expressed than Idgf1 and Idgf3.
messages: Secreted

7227:Dmel CG34159
gene id: 7227:Dmel_CG34159
uniprot id: Q9VL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

7227:Dmel CG31293
gene id: 7227:Dmel_CG31293
uniprot id: A0A0B4KH79
uniprot id: Q9VF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus
messages: Required for meiotic DNA recombination in females. Probably not involved in DNA repair and recombination in somatic cells.

7227:Dmel CG4871
gene id: 7227:Dmel_CG4871
uniprot id: Q9GU23
uniprot id: Q9W121
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7227:Dmel CG6789
gene id: 7227:Dmel_CG6789
uniprot id: Q9W4E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG17924
gene id: 7227:Dmel_CG17924
uniprot id: P16548
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By mating.
messages: In very late pupae and in adults.
messages: Main cells of the accessory glands of males.
messages: Secreted
messages: This protein may be a precursor of secreted proteins and peptide hormones.

7227:Dmel CG18174
gene id: 7227:Dmel_CG18174
uniprot id: Q9V3H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M67A family. PSMD14 subfamily.
messages: Component of the 19S regulatory cap of the 26S proteasome.
messages: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

7227:Dmel CG7071
gene id: 7227:Dmel_CG7071
uniprot id: Q8SXS0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG5474
gene id: 7227:Dmel_CG5474
uniprot id: Q9VUZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

7227:Dmel CG2213
gene id: 7227:Dmel_CG2213
uniprot id: Q9W0G6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
messages: Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules.
messages: spindle

7227:Dmel CG2747
gene id: 7227:Dmel_CG2747
uniprot id: A0A0B4KGF6
uniprot id: A0A0B4KGS8
uniprot id: Q32KD3
uniprot id: Q494I1
uniprot id: Q7KSW1
uniprot id: Q9VHW9
names: Similarity
messages: Belongs to the HEATR5 family.

7227:Dmel CG3186
gene id: 7227:Dmel_CG3186
uniprot id: Q9GU68
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Lys-51 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Severe larval growth defect.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

7227:Dmel CG8896
gene id: 7227:Dmel_CG8896
uniprot id: A1ZBR2
names: Similarity
messages: Belongs to the Toll-like receptor family.

7227:Dmel CG9620
gene id: 7227:Dmel_CG9620
uniprot id: Q9VHT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Golgi apparatus membrane
messages: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Plays a major role in the fucosylation of N-glycans. Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling.

7227:Dmel CG15533
gene id: 7227:Dmel_CG15533
uniprot id: Q9VA78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

7227:Dmel CG2041
gene id: 7227:Dmel_CG2041
uniprot id: Q961D9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCL9 family.
messages: Binds to ARM and PYGO.
messages: Expressed both maternally and zygotically throughout development.
messages: Involved in signal transduction through the Wnt pathway.
messages: Nucleus

7227:Dmel CG5627
gene id: 7227:Dmel_CG5627
uniprot id: A0A0S0X7U5
uniprot id: A0A1Z1CGX2
uniprot id: A0A1Z1CGY3
uniprot id: A0A1Z1CSK9
uniprot id: A8JUX2
uniprot id: M9NEH3
uniprot id: M9NGF2
uniprot id: M9PEM6
uniprot id: M9PJN3
uniprot id: Q9VXY2
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (By similarity).
messages: Membrane
messages: Partially edited. Target of Adar.

7227:Dmel CG16707
gene id: 7227:Dmel_CG16707
uniprot id: M9PHX2
uniprot id: Q8I0D8
uniprot id: Q9VT37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

7227:Dmel CG18600
gene id: 7227:Dmel_CG18600
uniprot id: Q9VE94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

7227:Dmel CG12327
gene id: 7227:Dmel_CG12327
uniprot id: Q9VUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7227:Dmel CG9428
gene id: 7227:Dmel_CG9428
uniprot id: Q7JZR2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3044
gene id: 7227:Dmel_CG3044
uniprot id: Q9W3V1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

7227:Dmel CG10648
gene id: 7227:Dmel_CG10648
uniprot id: Q9W3B2
names: Similarity
messages: Belongs to the MAK16 family.

7227:Dmel CG31755
gene id: 7227:Dmel_CG31755
uniprot id: Q9VL52
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Involved in primary piRNA biogenesis in germline cells.

7227:Dmel CG34403
gene id: 7227:Dmel_CG34403
uniprot id: H9XVM0
uniprot id: P91943
uniprot id: Q8IMA8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCF/LEF family.
messages: Binds to the beta-catenin homolog arm or to gro.
messages: Flies exhibit a segment polarity phenotype and altered expression of the wg target genes en and Ubx.
messages: Nucleus
messages: Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.

7227:Dmel CG32104
gene id: 7227:Dmel_CG32104
uniprot id: Q9VTX1
names: Similarity
messages: Belongs to the RPAP1 family.

7227:Dmel CG3241
gene id: 7227:Dmel_CG3241
uniprot id: P50534
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MSL2 family.
messages: Chromosome
messages: Component of the male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3.
messages: Nucleus
messages: Only produced in males.
messages: The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B.

7227:Dmel CG6013
gene id: 7227:Dmel_CG6013
uniprot id: Q9VE08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

7227:Dmel CG8268
gene id: 7227:Dmel_CG8268
uniprot id: Q9VSC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with Srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of Srp9 and Srp14 is required for SRP RNA binding (By similarity).
messages: Cytoplasm
messages: Heterodimer with Srp14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule and six protein subunits: Srp72, Srp68, Srp54, Srp19, Srp14 and Srp9 (By similarity).

7227:Dmel CG4663
gene id: 7227:Dmel_CG4663
uniprot id: Q7JRD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

7227:Dmel CG1809
gene id: 7227:Dmel_CG1809
uniprot id: Q7K3X8
names: Similarity
messages: Belongs to the alkaline phosphatase family.

7227:Dmel CG2849
gene id: 7227:Dmel_CG2849
uniprot id: P48555
uniprot id: Q962I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Cleavage furrow
messages: Membrane
messages: Midbody ring

7227:Dmel CG4236
gene id: 7227:Dmel_CG4236
uniprot id: C0MJE4
uniprot id: E1JIL4
uniprot id: Q24572
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.
messages: Highest level during early embryogenesis and then decreases in larvae, pupae and adults.
messages: Nucleus
messages: Probably binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Self associates. Associates with chromatin. Component of the CAF-1 complex, composed of Caf1-55, Caf1-105 and Caf1-180. Within the CAF-1 complex, Caf1-180 interacts directly with both Caf1-55 and Caf1-105. Component of the NuRD complex, composed of at least Caf1-55, Mi-2, MTA1-like and HDAC1/Rpd3. Within the NuRD complex, Caf1-55 may interact directly with Mi-2, MTA1-like and HDAC1/Rpd3. The NuRD complex may also associate with the methyl-DNA binding protein MBD-like via Caf1-55 and Mi-2. Component of the NURF complex, composed of Caf1-55, E(bx), Nurf-38 and Iswi. Component of the Esc/E(z) complex, composed of Caf1-55, esc, E(z), Su(z)1, and possibly Pho1. The Esc/E(z) complex may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis. Interacts with Rbf and Rbf2. Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, HDAC1/Rpd3 and l(3)mbt.

7227:Dmel CG32409
gene id: 7227:Dmel_CG32409
uniprot id: Q8I937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

7227:Dmel CG8425
gene id: 7227:Dmel_CG8425
uniprot id: A1ZA98
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG4909
gene id: 7227:Dmel_CG4909
uniprot id: Q7K4D1
names: Similarity
messages: Belongs to the SH3RF family.

7227:Dmel CG6235
gene id: 7227:Dmel_CG6235
uniprot id: A0A0B4LGZ3
uniprot id: C8VV30
uniprot id: P36872
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
messages: It is uncertain whether Met-1, Met-18, Met-33 or Met-44 is the initiator.
messages: PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme.

7227:Dmel CG5792
gene id: 7227:Dmel_CG5792
uniprot id: Q9VK57
names: Similarity
messages: Belongs to the PIH1 family.

7227:Dmel CG4969
gene id: 7227:Dmel_CG4969
uniprot id: Q9VM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7227:Dmel CG14234
gene id: 7227:Dmel_CG14234
uniprot id: Q9VWD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

7227:Dmel CG45019
gene id: 7227:Dmel_CG45019
uniprot id: E1JGU6
uniprot id: Q6NNF2
uniprot id: Q8MLR1
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Basal levels of phosphorylated kinase p38a/ERK2 are decreased significantly. Increased sensitivity to oxidative stress-induced death.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Expressed in Malpighian tubules and head.
messages: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299).

7227:Dmel CG32282
gene id: 7227:Dmel_CG32282
uniprot id: Q8IRD6
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG4705
gene id: 7227:Dmel_CG4705
uniprot id: Q9VKK2
names: Function
names: Subunit
messages: A component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development.
messages: Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13. Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13.

7227:Dmel CG7988
gene id: 7227:Dmel_CG7988
uniprot id: Q9VEB5
names: Function
names: Similarity
messages: Belongs to the SRR1 family.
messages: Possible regulator involved in a circadian clock input pathway.

7227:Dmel CG6016
gene id: 7227:Dmel_CG6016
uniprot id: A0A0B4K7Y4
uniprot id: A0A0B4KFL2
uniprot id: A1Z9D9
uniprot id: A1Z9E0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7227:Dmel CG1783
gene id: 7227:Dmel_CG1783
uniprot id: Q8MR31
names: Function
names: Subunit
names: Tissue Specificity
messages: In embryos, it is expressed throughout the CNS and in several peripheral locations. Colocalizes with Slo.
messages: Interacts with Slo.
messages: May selectively reduce calcium-activated potassium channel (Slo) currents by reducing the number of Slo channels in the plasma membrane.

7227:Dmel CG5840
gene id: 7227:Dmel_CG5840
uniprot id: A0A0B4KGC5
uniprot id: Q8IN96
uniprot id: Q9VEJ3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

7227:Dmel CG3738
gene id: 7227:Dmel_CG3738
uniprot id: A0A1B2AK90
uniprot id: Q24152
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases Cdk1 and Cdk2, and is essential for their biological function.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

7227:Dmel CG14505
gene id: 7227:Dmel_CG14505
uniprot id: A0A0B4K841
uniprot id: Q9V8F3
names: Similarity
messages: Belongs to the GSKIP family.

7227:Dmel CG7111
gene id: 7227:Dmel_CG7111
uniprot id: M9PB67
uniprot id: M9PCC1
uniprot id: O18640
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Highest expression in the mesodermal and endodermal lineages.
messages: Interacts with the 80S ribosome.
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).

7227:Dmel CG9829
gene id: 7227:Dmel_CG9829
uniprot id: Q9VFW4
names: Similarity
messages: Belongs to the ELP6 family.

7227:Dmel CG32268
gene id: 7227:Dmel_CG32268
uniprot id: Q9VZQ4
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG14549
gene id: 7227:Dmel_CG14549
uniprot id: Q9VBI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

7227:Dmel CG4531
gene id: 7227:Dmel_CG4531
uniprot id: Q00805
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: During embryogenesis, expression is in a segmental pattern in the ectoderm and in the nervous system. In the eye imaginal disks, expression in photoreceptor cells begins a few rows posterior to the morphogenetic furrow. Also expressed in the wing disk. In the adult, expression is seen in the retina and lamina.
messages: Flies exhibit transformation of the eye mystery cells, which are usually non-neuronal, into extra photoreceptors, and supernumerary cone cells and pigment cells are also recruited. Mutants also exhibit abnormal head involution, a change in a number of sensilla in the antennomaxillary complex and abnormal morphogenesis of the maxillary palp and wings in later stages.
messages: Interacts with spi.
messages: Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi).
messages: Secreted
messages: The three two-fingered repeats tightly encircle spi, providing the basis for it's sequestration. The first repeat harbors a 120 AA insert specific to drosophilidae.

7227:Dmel CG17336
gene id: 7227:Dmel_CG17336
uniprot id: Q08832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
messages: Cell membrane
messages: GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with Grd (alpha chain).
messages: Postsynaptic cell membrane

7227:Dmel CG5731
gene id: 7227:Dmel_CG5731
uniprot id: Q9VL27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

7227:Dmel CG5828
gene id: 7227:Dmel_CG5828
uniprot id: Q9VMU2
names: Subunit
messages: Homodimer. Interacts with PKM.

7227:Dmel CG4739
gene id: 7227:Dmel_CG4739
uniprot id: Q9VGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG30141
gene id: 7227:Dmel_CG30141
uniprot id: Q8MKK0
names: Function
names: Similarity
messages: Belongs to the PBP/GOBP family.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.

7227:Dmel CG11614
gene id: 7227:Dmel_CG11614
uniprot id: M9PCX7
uniprot id: M9PFM6
uniprot id: Q9VVV9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification.
messages: Cell membrane
messages: Cytoplasm
messages: Expression in embryos and imaginal disks is induced by activation of the Wnt signaling pathway.
messages: Highly expressed from 2-8 hours after egg laying (AEL). Expressed in broad anterior and posterior domains in stage 6 embryos (late cellular blastoderm). Almost ubiquitous in stage 8/9 embryos with higher levels anterior to the hh/en stripe. This anterior bias persists in stage 10 embryos. Absent from hh/en-producing cells. Expressed in the wing margins of third instar larvae.
messages: Interacts with dsh. This interaction may be stabilized by zinc.
messages: Membrane
messages: Nucleus

7227:Dmel CG2140
gene id: 7227:Dmel_CG2140
uniprot id: E9P245
uniprot id: Q9V4N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Cytochrome b5 is a membrane-bound hemoprotein which functions as an electron carrier for several membrane-bound oxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

7227:Dmel CG17084
gene id: 7227:Dmel_CG17084
uniprot id: Q9W0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG4869
gene id: 7227:Dmel_CG4869
uniprot id: Q8MST5
uniprot id: Q9VAX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7227:Dmel CG11412
gene id: 7227:Dmel_CG11412
uniprot id: M9PGL2
uniprot id: Q95RC0
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.
messages: Probable catalytic component of a complex displaying alpha (N-terminal) acetyltransferase activity.

7227:Dmel CG6637
gene id: 7227:Dmel_CG6637
uniprot id: Q9VD72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

7227:Dmel CG11777
gene id: 7227:Dmel_CG11777
uniprot id: Q8MKJ6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG5155
gene id: 7227:Dmel_CG5155
uniprot id: Q9VM21
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Tissue Specificity
messages: Gudu is Chinese for 'alone without progeny' and refers to the male infertility phenotype.
messages: Highly expressed in testis.
messages: Important for spermatogenesis where it may have a role in sperm individualization.
messages: RNAi-mediated knockdown severely impairs male fertility. Morphology of the sperm individualization complex is highly abnormal. Seminal vesicles contain very few mature spermatozoa, which are often bundled together. Female fertility is not affected.

7227:Dmel CG16993
gene id: 7227:Dmel_CG16993
uniprot id: Q9VPH0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal wing hair polarity and in many wing cells forming two or more hairs instead of the normal single hair.
messages: Belongs to the inturned family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with mwh.
messages: Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing. Probably acts by regulating ciliogenesis.

7227:Dmel CG3711
gene id: 7227:Dmel_CG3711
uniprot id: Q9V410
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the LZTR1 family.
messages: Component of some BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
messages: Expressed in Rdl-expressing neurons of the mushroom body, the neurons projecting to the LC9 optic glomerulus and in a neuronal cluster near the subesophageal ganglion (at protein level).
messages: Flies are viable but most wings show wing vein defects characterized by extra veins and vein tissue, which are caused by an increase of Ras-MAPK signaling (PubMed:30442766, PubMed:32339168). Decreases sleep with night-time sleep-fragmentation patterns, primarily during the second part of the night (PubMed:32339168). RNAi-mediated knockdown in neurons of males results in reduced total sleep in combination with decreased locomotor activity, increased Ras-MAPK signaling and altered metabolism including reduced glycogen levels and increased levels of triglycerides (PubMed:32339168). RNAi- mediated knockdown in GABAA-receptor-expressing neurons causes a shortening of sleep bouts and an increase in their number during night, with an effect size similar to that seen with pan-neuronal knockdown (PubMed:32339168). RNAi-mediated knockdown in peripheral class-IV dendritic arborization neurons does not cause increased proliferation in the nervous system (PubMed:32339168). Adult-specific RNAi-mediated neuronal knockdown decreases night-time sleep compared to controls and caused an increased number of short sleep bouts during the night (PubMed:32339168). RNAi-mediated knockdown of in GABAB-receptor-expressing neurons or PDF-expressing clock neurons-had no significant effect on night-time sleep-bout number or duration (PubMed:32339168). Simultaneous knockdown of Lztr1 and Nf1 reduces total night-time sleep, increases night-time sleep fragmentation and activates the Ras pathway similarly to single knockdown (PubMed:32339168).
messages: Inhibitor of Ras signaling (PubMed:30442766). Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (By similarity). Together with Nf1, plays an important role for normal sleep behavior, mainly during the night (PubMed:32339168). Might affect sleep by modulating GABA signaling in Rdl-expressing neurons (PubMed:32339168). Might play a role in the regulation of brain glycogen metabolism and organismal levels of triglycerides (PubMed:32339168).

7227:Dmel CG33815
gene id: 7227:Dmel_CG33815
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG11660
gene id: 7227:Dmel_CG11660
uniprot id: Q9VTL5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

7227:Dmel CG9338
gene id: 7227:Dmel_CG9338
uniprot id: Q9VIH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG8674
gene id: 7227:Dmel_CG8674
uniprot id: Q9VID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

7227:Dmel CG14637
gene id: 7227:Dmel_CG14637
uniprot id: Q9V3C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase. Is essential for the directed and fasciculated early outgrowth of the bolwig nerves, as well as for its navigation at later stages. Is required during post-transcriptional gene expression. Plays a role during morphogenetic process, apoptosis and the establishment of cell polarity.
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.
messages: Nucleus

7227:Dmel CG8493
gene id: 7227:Dmel_CG8493
uniprot id: E1JH43
uniprot id: Q7JUX2
names: Similarity
messages: Belongs to the peptidase C48 family.

7227:Dmel CG15804
gene id: 7227:Dmel_CG15804
uniprot id: Q7KVA7
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG12490
gene id: 7227:Dmel_CG12490
uniprot id: Q9W1Z2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8008
gene id: 7227:Dmel_CG8008
uniprot id: B7YZU3
uniprot id: Q7K0G5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8285
gene id: 7227:Dmel_CG8285
uniprot id: C4XVJ6
uniprot id: P22815
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for sevenless tyrosine-kinase receptor during eye development.
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Expressed exclusively by R8 photoreceptor cells and is internalized in a sev-dependent manner by R7 cells.
messages: Membrane

7227:Dmel CG6412
gene id: 7227:Dmel_CG6412
uniprot id: Q9VJC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

7227:Dmel CG12442
gene id: 7227:Dmel_CG12442
uniprot id: A1Z949
names: Similarity
messages: Belongs to the lin-52 family.

7227:Dmel CG4357
gene id: 7227:Dmel_CG4357
uniprot id: M9PCA7
uniprot id: M9PI37
uniprot id: Q9VTW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7227:Dmel CG11109
gene id: 7227:Dmel_CG11109
uniprot id: Q8IPS4
uniprot id: Q9VNQ1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

7227:Dmel CG33183
gene id: 7227:Dmel_CG33183
uniprot id: A0A0B4KEJ3
uniprot id: A0A384SX09
uniprot id: A1Z858
uniprot id: A8DY91
uniprot id: H1UUN3
uniprot id: P31396
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus
messages: Putative receptor whose ligand is not yet known.
messages: The expression of this protein is developmentally regulated showing peaks at midembryogenesis. HR3 transcription is ecdysone-induced.

7227:Dmel CG17195
gene id: 7227:Dmel_CG17195
uniprot id: Q9VBM5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG1120
gene id: 7227:Dmel_CG1120
uniprot id: Q9VZM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 10 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). May be involved in the 3'-end processing of the spliceosomal snRNAs U1, U2, U4 and U5 but is probably not essential for 3'-end processing of the snRNA U7 (PubMed:21078872, PubMed:23097424).
messages: Nucleus

7227:Dmel CG10924
gene id: 7227:Dmel_CG10924
uniprot id: A8DYI3
uniprot id: Q7JXB5
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

7227:Dmel CG32163
gene id: 7227:Dmel_CG32163
uniprot id: Q8IQP3
uniprot id: X2J948
names: Similarity
messages: Belongs to the NATD1 family.

7227:Dmel CG5112
gene id: 7227:Dmel_CG5112
uniprot id: Q9VBQ5
names: Similarity
messages: Belongs to the amidase family.

7227:Dmel CG15749
gene id: 7227:Dmel_CG15749
uniprot id: Q9VYE0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG2857
gene id: 7227:Dmel_CG2857
uniprot id: Q9W0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG16790
gene id: 7227:Dmel_CG16790
uniprot id: B5X522
uniprot id: Q9VHB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation.
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

7227:Dmel CG5327
gene id: 7227:Dmel_CG5327
uniprot id: Q7JY26
names: Similarity
messages: Belongs to the FAM136 family.

7227:Dmel CG33910
gene id: 7227:Dmel_CG33910
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG16905
gene id: 7227:Dmel_CG16905
uniprot id: Q9VH58
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family.
messages: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in females. Little or no expression detected in males.
messages: RNAi-mediated knockdown results in an altered hydrocarbon profile in females, with significantly increased levels of C25 7,11-dienes and reduced levels of C27 7,11-dienes. Monounsaturated and saturated hydrocarbon levels are also affected with increased levels of C23 fatty acids and reduced levels of C27 fatty acids. Males have a normal hydrocarbon profile. RNAi-mediated knockdown in females (mated to wild-type males) results in impaired courtship behavior with reduced numbers of copulation attempts and increased copulation latency.

7227:Dmel CG2022
gene id: 7227:Dmel_CG2022
uniprot id: Q9VN75
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG4810
gene id: 7227:Dmel_CG4810
uniprot id: Q9VGC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

7227:Dmel CG9065
gene id: 7227:Dmel_CG9065
uniprot id: Q9VXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

7227:Dmel CG6033
gene id: 7227:Dmel_CG6033
uniprot id: Q08012
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:8462097, PubMed:22615583, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583).
messages: Belongs to the GRB2/sem-5/DRK family.
messages: Embryonically lethal (PubMed:30610177). Loss in Johnston's organ causes scolopidium abnormalities (PubMed:30610177).
messages: Found mainly in the developing eye and in the antennal disk. Also observed in other imaginal disks tested and in the embryo. Expressed in Johnston's organ, the hearing organ, neurons (at protein level) (PubMed:30610177).
messages: Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains (PubMed:12128212, PubMed:8462097, PubMed:8462098, PubMed:9671493). Binds to tyrosine phosphorylated Dab via the SH2 domain (PubMed:9671493). Interacts with phosphorylated Ack (PubMed:22615583).
messages: Membrane
messages: Synapse

7227:Dmel CG8323
gene id: 7227:Dmel_CG8323
uniprot id: Q7JZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG6143
gene id: 7227:Dmel_CG6143
uniprot id: P41073
names: Developmental Stage
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Chromosome
messages: Expressed both maternally and zygotically, zygotic expression is at a low and constant level thereafter.
messages: Intron retention.
messages: May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci.
messages: Nucleus

7227:Dmel CG31792
gene id: 7227:Dmel_CG31792
uniprot id: Q9VJ21
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG17330
gene id: 7227:Dmel_CG17330
uniprot id: Q9VJK8
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily.
messages: Highly expressed in the first instar larvae and then gradually decreases during larval development. Expression increases again in the wandering third larval stage. The lowest amount of expression is observed in the early and mid-pupal stages. After this, expression increases in the late pupal stage in both male and female adults.
messages: O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:18549957). Also able to methylate farnesoate to methyl farnesoate (PubMed:18549957).
messages: Predominantly expressed in corpora allata. Also expressed at low level in testis.

7227:Dmel CG11254
gene id: 7227:Dmel_CG11254
uniprot id: A0A0S0WNT6
uniprot id: Q9VNS0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the maelstrom family.
messages: Cytoplasm
messages: Female sterility and defects in karyosome formation and oocyte polarity due to transposable element derepression. Ovary shows mislocalization of 2 proteins involved in the microRNA and/or RNAi pathways, Dicer and AGO2. In testis, transit-amplifying cysts fail to differentiate into primary spermatocytes, instead breaking down into ectopic germline stem cells (GSC) and smaller cysts, due to a depletion of Bag-of-marbles (Bam) protein.
messages: In germaria and egg chambers, it is detected in the germline. In the germarium, it is in all regions, including region I where the germ cells are dividing. In early egg chambers, it is uniformly distributed throughout the nurse cells and oocyte but, by stage 5, it is most concentrated around the outer margins of the cells, closest to the periphery of the egg chamber. Level decreases in stages 5 and 6, but most noticeably in the oocyte, where protein level remains. No detectable protein from stage 8 onward (at protein level).
messages: Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes.
messages: Nucleus

7227:Dmel CG12077
gene id: 7227:Dmel_CG12077
uniprot id: Q9VZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

7227:Dmel CG32789
gene id: 7227:Dmel_CG32789
uniprot id: C4NYP8
uniprot id: E2QD63
uniprot id: Q86DS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM10 family.
messages: Cytoplasm
messages: Homotetramer. Interacts with Hsc70 as well as DNAJ homologs and Hsp90 (By similarity).
messages: One HIP oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on activation of the Hsc70 ATPase by Hsp40. Stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of Hsc70 with various target proteins (By similarity).

7227:Dmel CG10833
gene id: 7227:Dmel_CG10833
uniprot id: Q9VMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG7961
gene id: 7227:Dmel_CG7961
uniprot id: Q9W0B8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

7227:Dmel CG8376
gene id: 7227:Dmel_CG8376
uniprot id: E1JGX9
uniprot id: E1JGY0
uniprot id: P29673
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in PNS and CNS.
messages: Nucleus
messages: Required for the normal development of the wing and halter imaginal disks.

7227:Dmel CG3658
gene id: 7227:Dmel_CG3658
uniprot id: O96989
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

7227:Dmel CG1046
gene id: 7227:Dmel_CG1046
uniprot id: P09089
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.

7227:Dmel CG7930
gene id: 7227:Dmel_CG7930
uniprot id: P47949
names: Similarity
names: Tissue Specificity
messages: Belongs to the troponin C family.
messages: Present in both larval and adult muscles.

7227:Dmel CG11895
gene id: 7227:Dmel_CG11895
uniprot id: A0A0B4JD63
uniprot id: A0A0B4K6X2
uniprot id: A0A0B4KER2
uniprot id: A0A0B4LG27
uniprot id: E1JH30
uniprot id: Q9V5N8
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: At 12 hours after puparium formation (apf), expressed evenly at cell boundaries. By 30 hours apf, expression is concentrated at proximal and distal cell boundaries with little or no expression at anterior and posterior boundaries. When prehairs emerge at 30-36 hours apf, expression becomes evenly distributed again along the whole cell boundary.
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: In the pupal wing, expressed at relatively even levels in all regions. Abundant in 6-9 hours embryos. Expressed at higher levels in pupae than larvae.
messages: Interacts with ATP6AP2 (via N-terminus).
messages: Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2 (PubMed:23292348).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG2105
gene id: 7227:Dmel_CG2105
uniprot id: A1Z709
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8989
gene id: 7227:Dmel_CG8989
uniprot id: C0HL66
uniprot id: C0HL67
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: High levels of expression in ovaries and relatively weak expression in the testes. Highest levels of expression in embryos.
messages: Low levels of expression in ovaries and moderate levels of expression in the testes. Highest levels of expression in embryos.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression. Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Daxx (via C-terminus) (PubMed:28320872).
messages: This histone is the predominant form in non-dividing cells.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

7227:Dmel CG10653
gene id: 7227:Dmel_CG10653
uniprot id: Q24185
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hook family.
messages: Endosome
messages: Homodimer. Interacts with microtubules via its N-terminus.
messages: Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity.
messages: Life span reduction.
messages: Synapse
messages: The coiled coil domain mediates homodimerization.
messages: cytoskeleton

7227:Dmel CG32113
gene id: 7227:Dmel_CG32113
uniprot id: Q9VU08
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the VPS13 family.
messages: Cytoplasm
messages: Expressed in intestinal cells (at protein level).
messages: Lysosome
messages: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis (PubMed:29307555).
messages: RNAi-mediated knockdown leads to 100% lethality at the larval or pupal stage.
messages: The UBA domain binds to 'Lys-63'-linked polyubiquitin chains, but neither to linear nor 'Lys-48'-linked polyubiquitin chains. Required for mitochondrial size regulation and for mitochondrial clearance in the intestine.

7227:Dmel CG31666
gene id: 7227:Dmel_CG31666
uniprot id: Q9VQ30
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Broadly expressed in the developing larval central nervous system (at protein level) (PubMed:17055440). Expressed in the larval lymph gland and circulating hemocytes (at protein level) (PubMed:20412771). Expressed in all cell types of the adult testis stem cell niche but not detected in somatic cells of the adult ovary (at protein level) (PubMed:29389999). In the testis, expressed at high levels in cyst stem cells and early cyst cells and, at lower levels, in germline stem cells (at protein level) (PubMed:20412771).
messages: In the mushroom body, abundant at early larval stages, becomes much reduced in wandering larvae and is undetectable in young pupae. Expressed at higher levels in postmitotic neurons born at early postembryonic developmental stages than in later-born neurons of the same lineage.
messages: Inappropriate morphogenesis of larval mushroom body neurons with early-born neurons adopting the fate of late-born neurons from the same lineage (PubMed:17055440). Malformed eyes and head capsules due to defects in eye progenitor cells (PubMed:20412771). RNAi-mediated knockdown in adult cyst stem cells and early cyst cells results in the appearance of cells resembling ovarian follicle cells throughout the testis (PubMed:25453558). RNAi-mediated knockdown in adult cyst stem cells results in loss of expression of the male-specific isoform of transcription factor dsx and leads to male sterility (PubMed:29389999). RNAi-mediated knockdown in imaginal wing disks results in decreased levels of nuclear actin (PubMed:26021350). RNAi-mediated knockdown in adult ovary somatic stem cells results in ovaries which are morphologically indistinguishable from the wild-type while ectopic expression in the adult ovary is sufficient to induce male fate in somatic cells (PubMed:26811385).
messages: Nucleus
messages: Required for morphological differentiation of postmitotic neurons during postembryonic brain development (PubMed:17055440). Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage (PubMed:17055440). Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis (PubMed:20412771). In the adult testis, maintains the male identify of adult somatic cyst stem cells (PubMed:25453558, PubMed:29389999). Represses expression and alternative splicing of transformer pre-mRNA, resulting in the production of the male-specific isoform of transcription factor dsx which ensures male-specific transcription of target genes (PubMed:25453558, PubMed:29389999). Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi (PubMed:26021350). This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import (PubMed:26021350).

7227:Dmel CG9578
gene id: 7227:Dmel_CG9578
uniprot id: Q9W5W6
names: Similarity
messages: Belongs to the TIP41 family.

7227:Dmel CG34073
gene id: 7227:Dmel_CG34073
uniprot id: B6E0T5
uniprot id: P00850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

7227:Dmel CG14630
gene id: 7227:Dmel_CG14630
uniprot id: Q9W5B5
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

7227:Dmel CG10978
gene id: 7227:Dmel_CG10978
uniprot id: E2QD00
uniprot id: Q7K1V5
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Jagunal' means 'small egg'.
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mutants can't increase the size of their oocyte during oogenesis.
messages: Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis. Required for oocyte and bristle growth.

7227:Dmel CG33177
gene id: 7227:Dmel_CG33177
uniprot id: Q86B54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

7227:Dmel CG5562
gene id: 7227:Dmel_CG5562
uniprot id: A0A0B4LGA7
uniprot id: P27091
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Expressed in cells of the developing foregut and hindgut during germ band retraction and later embryonic stages. Expressed in the wing disk, mainly in the posterior compartment in the pteropleural and medial regions extending into the progenitors of the scutellum. High levels are found within the posterior and anterior compartments of the wing pouch and low levels in the hinge region. In the eye/antennal disk, expression is highest anterior to the morphogenetic furrow and in the medial regions with lower levels of expression posterior to the morphogenetic furrow. Expressed throughout the posterior compartment of the leg imaginal disks and within the ventral anterior compartment.
messages: Expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males.
messages: Flies exhibit transparent larvae, and a reduction of the adult wing size.
messages: Homodimer; disulfide-linked (PubMed:1601181). Interacts with nord and dpp (PubMed:35037619).
messages: Required for the growth of imaginal tissues and for patterning of the adult wing.
messages: Secreted

7227:Dmel CG10234
gene id: 7227:Dmel_CG10234
uniprot id: P25722
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Was originally thought to be SD.

7227:Dmel CG14516
gene id: 7227:Dmel_CG14516
uniprot id: Q7KRW4
uniprot id: Q9VAP0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG45799
gene id: 7227:Dmel_CG45799
uniprot id: B4F7L9
names: Miscellaneous
names: Tissue Specificity
messages: Chromosome mapping suggests that WDY is fully contained in the kl-1 region, and WDY may correspond to this fertility factor.
messages: Strongly expressed in testis and weakly in the soma.

7227:Dmel CG11471
gene id: 7227:Dmel_CG11471
uniprot id: Q8MSW0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG11281
gene id: 7227:Dmel_CG11281
uniprot id: Q9VU52
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Component of the sperm acrosome membrane (PubMed:17092953). Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization (PubMed:9630751, PubMed:17092953).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Specifically expressed in testis.
messages: acrosome membrane

7227:Dmel CG9747
gene id: 7227:Dmel_CG9747
uniprot id: Q9VA94
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG1454
gene id: 7227:Dmel_CG1454
uniprot id: P15619
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Distribution varies between nurse cells and the oocyte during oogenesis. Weakly expressed in follicle and border cells.
messages: Expressed both maternally and zygotically. Expressed from stage 1 of oogenesis. Expressed at a low level in the embryo from the tenth nuclear division to the end of cellularization in all cell nuclei except those of pole cells. Also weakly expressed in the embryo after germ-band retraction, and in larvae (at protein level).
messages: May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte.
messages: Nucleus

7227:Dmel CG42383
gene id: 7227:Dmel_CG42383
uniprot id: Q9W175
names: Subcellular Location Annotation
messages: Golgi stack

7227:Dmel CG8799
gene id: 7227:Dmel_CG8799
uniprot id: A0A0B4KEG2
uniprot id: P91660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Membrane
messages: Uniform expression in embryos.
messages: Vital for development.

7227:Dmel CG8201
gene id: 7227:Dmel_CG8201
uniprot id: A1ZBL5
uniprot id: A1ZBL9
uniprot id: E1JGN0
uniprot id: Q9V8V8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

7227:Dmel CG10667
gene id: 7227:Dmel_CG10667
uniprot id: O16810
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

7227:Dmel CG5723
gene id: 7227:Dmel_CG5723
uniprot id: M9PGF7
uniprot id: O61307
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cytoplasm
messages: Expressed in muscles and motor neurons (at protein level).
messages: Expressed in the central nervous system and heart. Expressed in the developing antennal lobe. Expressed in subset of matching olfactory receptor neurons (ORN) and projection neurons (PN) in select glomeruli between 12 to 48 hours after puparium formation (apf) (at protein level). Expressed in odd-numbered blastoderm parasegments, the central nervous system, muscle attachment points and tracheal precursor cells. Expressed in the ventral nerve cord, the cardiac mesoderm and epidermis at late embryonic stages. Expressed in all imaginal disks.
messages: Homodimer. Heterodimer with Ten-a. Interacts with Ten-a; the interaction occurs at the neuromuscular junction. Interacts with alpha-Spec and cher.
messages: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phosphorylated. Phosphorylation occurs at tyrosine residues.
messages: Postsynaptic cell membrane
messages: Proteolytically cleaved.
messages: Shows peripheral motor neuron axon guidance defects.
messages: The name odz (odd Oz) reflects the odd pair rule nature of the gene and Oz reflects the prominent expression of the gene in the brain, heart and neurons, corresponding to the three gifts that the Wizard of Oz bestowed.
messages: synaptosome

7227:Dmel CG11422
gene id: 7227:Dmel_CG11422
uniprot id: Q23970
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antenna. Mostly expressed in two types of sensory hairs, sensilla trichodea and small sensilla basiconica, in the ventro-lateral region of the third antennal segment (at protein level).
messages: Belongs to the PBP/GOBP family.
messages: Expressed in adult but not in larval olfactory organs.
messages: Secreted

7227:Dmel CG17560
gene id: 7227:Dmel_CG17560
uniprot id: Q9VES6
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG3038
gene id: 7227:Dmel_CG3038
uniprot id: Q8IRZ0
uniprot id: Q95RP8
uniprot id: X2JD78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG9994
gene id: 7227:Dmel_CG9994
uniprot id: Q9VIW6
names: Subcellular Location Annotation
messages: phagosome membrane

7227:Dmel CG17768
gene id: 7227:Dmel_CG17768
uniprot id: Q9VKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

7227:Dmel CG3539
gene id: 7227:Dmel_CG3539
uniprot id: Q24179
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Cytoplasm
messages: Differs from position 182 onward for unknown reasons.
messages: In embryos, from stage 14, expression is seen in posterior midgut, esophagus and salivary glands. No expression is seen in larval imaginal disks.
messages: Membrane
messages: Non-vital for development.

7227:Dmel CG11840
gene id: 7227:Dmel_CG11840
uniprot id: Q9VPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

7227:Dmel CG30381
gene id: 7227:Dmel_CG30381
uniprot id: A0A0B4LES9
uniprot id: A8DY62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.

7227:Dmel CG14527
gene id: 7227:Dmel_CG14527
uniprot id: Q9VAS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG5603
gene id: 7227:Dmel_CG5603
uniprot id: Q8IPC3
uniprot id: Q8IPC5
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

7227:Dmel CG2621
gene id: 7227:Dmel_CG2621
uniprot id: A4V3W1
uniprot id: A4V3W2
uniprot id: A8JUV9
uniprot id: B6IDN4
uniprot id: C0PUX5
uniprot id: H5V852
uniprot id: M9PGC4
uniprot id: M9PGV7
uniprot id: P18431
uniprot id: Q0KHW6
uniprot id: Q7KVY5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Expressed in ovaries and activated eggs (at protein level). Expression is over all the embryo at all stages, no local accumulation is observed.
messages: Interacts with cos.
messages: Intron retention.
messages: Isoform SGG46 is expressed at low levels in 12-24 hours embryos. Isoform Zygotic and isoform SGG39 are expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages (at protein level). Isoform Zygotic is expressed maternally and zygotically but reduced throughout later embryonic development. Expression persists throughout larval stages.
messages: Major isoform.
messages: Mutants display an overdeveloped neuromuscular junction (NMJ), with the number of boutons greatly increased.
messages: Nucleus
messages: Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering calcineurin activation via sra phosphorylation. Phosphorylates microtubule-associated protein futsch in axons.
messages: Synapse
messages: axon
messages: cell cortex
messages: centrosome

7227:Dmel CG32857
gene id: 7227:Dmel_CG32857
uniprot id: Q8SY96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion
messages: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.

7227:Dmel CG14782
gene id: 7227:Dmel_CG14782
uniprot id: O76902
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Endosome membrane
messages: Functions in the regulation of endosome morphology and late endosome formation. Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes. Important for localization of Gdi to the endosomal membranes. May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and VhaSFD.
messages: In ovaries, expressed both in the germ line cells and in the overlying somatic follicular epithelium.
messages: Interacts with Gdi (Rab GDP dissociation inhibitor).
messages: No visible phenotype. No effect on the subcellular localization or expression of Rab7, Rab11 and Avl.
messages: The FYVE-type zinc finger domain is necessary and sufficient for endosome targeting and localization to the plasma membrane.
messages: The name 'rush hour' derives from the overexpression phenotype which displays a disruption to endosomal trafficking and cargo progression.
messages: cell cortex

7227:Dmel CG18417
gene id: 7227:Dmel_CG18417
uniprot id: Q9VS67
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG3107
gene id: 7227:Dmel_CG3107
uniprot id: Q9V9E3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity).
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.
messages: Mitochondrion

7227:Dmel CG9603
gene id: 7227:Dmel_CG9603
uniprot id: A0A0B4K6C3
uniprot id: Q9VHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIa family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

7227:Dmel CG4709
gene id: 7227:Dmel_CG4709
uniprot id: Q9VL59
uniprot id: X2JA03
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription repressor.

7227:Dmel CG6538
gene id: 7227:Dmel_CG6538
uniprot id: P41900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIF beta subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

7227:Dmel CG18314
gene id: 7227:Dmel_CG18314
uniprot id: Q9VZD1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG3431
gene id: 7227:Dmel_CG3431
uniprot id: Q9XZ61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex, at least composed of calypso and Asx.
messages: Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

7227:Dmel CG17065
gene id: 7227:Dmel_CG17065
uniprot id: E1JJR9
uniprot id: Q9VR81
uniprot id: X2JFY0
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

7227:Dmel CG32095
gene id: 7227:Dmel_CG32095
uniprot id: Q95U65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

7227:Dmel CG7619
gene id: 7227:Dmel_CG7619
uniprot id: M9PIG8
uniprot id: P55035
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S5A family.
messages: Binds and presumably selects ubiquitin-conjugates for destruction.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Interacts with Ubc4.

7227:Dmel CG32283
gene id: 7227:Dmel_CG32283
uniprot id: Q8IRD7
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG11255
gene id: 7227:Dmel_CG11255
uniprot id: Q9VU38
uniprot id: Q9VU39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

7227:Dmel CG17843
gene id: 7227:Dmel_CG17843
uniprot id: Q9VD61
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

7227:Dmel CG2674
gene id: 7227:Dmel_CG2674
uniprot id: A4UZW2
uniprot id: C8VV92
uniprot id: P40320
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Expressed both maternally and zygotically. Expressed throughout development with highest levels at adult stages.

7227:Dmel CG4615
gene id: 7227:Dmel_CG4615
uniprot id: Q9W3S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7227:Dmel CG7990
gene id: 7227:Dmel_CG7990
uniprot id: Q9VWK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

7227:Dmel CG10635
gene id: 7227:Dmel_CG10635
uniprot id: A0A1B2AKD0
uniprot id: Q9VRL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7227:Dmel CG8983
gene id: 7227:Dmel_CG8983
uniprot id: Q3YMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7227:Dmel CG5827
gene id: 7227:Dmel_CG5827
uniprot id: M9MRF2
uniprot id: Q9VMU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

7227:Dmel CG31523
gene id: 7227:Dmel_CG31523
uniprot id: Q95T98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG12079
gene id: 7227:Dmel_CG12079
uniprot id: Q9VZU4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion
messages: Part of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (By similarity). Interacts with sicily; interaction is stronger with unprocessed sicily protein (PubMed:23509070).
messages: Upon mitochondrial dysfunction, the translation of the mRNA occurring on the mitochondrial surface is impaired and amino acids non-coded by the RNA template are added to the C-terminal of the protein. The C-terminal extended proteins aggregates in the cytosol and are toxic. The phenomenon is called mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE).

7227:Dmel CG4897
gene id: 7227:Dmel_CG4897
uniprot id: P32100
uniprot id: X2J5G6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).

7227:Dmel CG15014
gene id: 7227:Dmel_CG15014
uniprot id: Q9VZD8
names: Similarity
messages: Belongs to the THUMPD1 family.

7227:Dmel CG6579
gene id: 7227:Dmel_CG6579
uniprot id: Q9VK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG4827
gene id: 7227:Dmel_CG4827
uniprot id: Q7K0L5
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

7227:Dmel CG6728
gene id: 7227:Dmel_CG6728
uniprot id: A0A0B4K737
uniprot id: Q9VGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GMC oxidoreductase family.
messages: Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.
messages: Secreted

7227:Dmel CG5413
gene id: 7227:Dmel_CG5413
uniprot id: Q9VEK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

7227:Dmel CG7083
gene id: 7227:Dmel_CG7083
uniprot id: Q9VSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAF1 family.
messages: Cytoplasm
messages: May play a regulatory role in autophagic activity.
messages: Preautophagosomal structure

7227:Dmel CG42698
gene id: 7227:Dmel_CG42698
uniprot id: A0A0B4JD55
uniprot id: A0A0B4LEG2
uniprot id: B7YZU0
uniprot id: Q7JUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

7227:Dmel CG9533
gene id: 7227:Dmel_CG9533
uniprot id: M9NF51
uniprot id: M9PEL4
uniprot id: M9PH52
uniprot id: M9PHL3
uniprot id: M9PJN1
uniprot id: P32870
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by calcium/calmodulin and G protein.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit.
messages: Membrane
messages: Mushroom bodies of the fly brain.
messages: This is a membrane-bound, calmodulin-sensitive adenylyl cyclase. Inactivation of this cyclase leads to a learning and memory defect.

7227:Dmel CG18624
gene id: 7227:Dmel_CG18624
uniprot id: Q9W3N7
names: Function
names: Similarity
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.

7227:Dmel CG4261
gene id: 7227:Dmel_CG4261
uniprot id: Q9VF02
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG15855
gene id: 7227:Dmel_CG15855
uniprot id: P48593
names: Induction
messages: By ecdysone.

7227:Dmel CG8188
gene id: 7227:Dmel_CG8188
uniprot id: Q9VX25
uniprot id: X2JFX0
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

7227:Dmel CG11219
gene id: 7227:Dmel_CG11219
uniprot id: Q9W3E2
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Phosphorylated by aPKC which lowers lipid affinity and promotes dissociation from the cell cortex (PubMed:26481050, PubMed:32579558). In the photoreceptor cells, aPKC-mediated phosphorylation leads to its displacement from the stalk apical cortex and thus restricts its localization to the rhabdomeric apical cortex where it functions (PubMed:32579558). Dephosphorylation appears to be light-dependent (PubMed:9697866).
messages: Required for the morphological differentiation and maintenance of the rhabdomeric photoreceptor apical domain (PubMed:32579558). Acts as a downstream component of the gl and Pph13 transcriptional pathway which is required for photoreceptor cell development (PubMed:32579558). Likely to function by regulating the trafficking or retention of rhabdomeric proteins including the phototransduction proteins ninaE and didum (PubMed:32579558).
messages: Restricted to photoreceptor cells (at protein level) (PubMed:32579558). Not detected until approximately 48hrs after puparium formation (APF) and then maintained in the photoreceptor cells post-eclosion (at protein level) (PubMed:32579558).
messages: The phospho-regulated basic and hydrophobic (PRBH) motif is sufficient and important for interaction with phospholipids permitting cortical localization (PubMed:26481050). Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane (PubMed:26481050, PubMed:32579558).
messages: Viable however, rhabdomeres are flat and oblong, and alignment or organization of the microvillar projections along the depth of the retina are not maintained (PubMed:32579558). Severity of the phenotype increases with age, by seven days post-eclosion rhabdomeres have become irregular, misaligned and fragmented structures (PubMed:32579558). The phototransduction proteins ninaE and, to a much lesser extent, didum are displaced from vesicles near the rhabdomere terminal web and instead become mislocalized to the basal lateral membranes (PubMed:32579558). Photoactivation of ninaE and phototransduction are unaffected, and amplitudes of light response is enhanced at higher light intensities (PubMed:32579558).
messages: cell cortex
messages: cytosol

7227:Dmel CG31040
gene id: 7227:Dmel_CG31040
uniprot id: Q9VAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG7 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi function.

7227:Dmel CG14585
gene id: 7227:Dmel_CG14585
uniprot id: Q9VVL1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Expressed in acetic-acid-sensing neurons in the antennal coeloconic 2 (ac2) and antennal coeloconic 3 (ac3) sensilla class of sensory hairs (at protein level).
messages: Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a.
messages: Severely reduced response to acetic and propionic acid.
messages: dendrite

7227:Dmel CG10086
gene id: 7227:Dmel_CG10086
uniprot id: Q8SYU5
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG2098
gene id: 7227:Dmel_CG2098
uniprot id: Q9V9S8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferrochelatase family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Catalyzes the ferrous insertion into protoporphyrin IX (PubMed:9712849). Terminal enzyme in heme biosynthesis (PubMed:9712849). Contains four conserved cysteines that function as cluster ligands and play a crucial role in maintaining protein structure (PubMed:9712849).
messages: Mitochondrion inner membrane
messages: Monomer.

7227:Dmel CG6905
gene id: 7227:Dmel_CG6905
uniprot id: Q9W0R0
names: Similarity
messages: Belongs to the CEF1 family.

7227:Dmel CG42344
gene id: 7227:Dmel_CG42344
uniprot id: A0A0B4K6V0
uniprot id: A0A0B4K7K9
uniprot id: A0A0B4K7V8
uniprot id: A0A0B4K843
uniprot id: A0A0B4KF38
uniprot id: A1Z7V1
uniprot id: A8DY79
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG14411
gene id: 7227:Dmel_CG14411
uniprot id: Q9VY15
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7227:Dmel CG5948
gene id: 7227:Dmel_CG5948
uniprot id: A0A0B4K763
uniprot id: Q9VBK8
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.

7227:Dmel CG8135
gene id: 7227:Dmel_CG8135
uniprot id: Q8MRQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Membrane

7227:Dmel CG6992
gene id: 7227:Dmel_CG6992
uniprot id: Q9VMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Membrane

7227:Dmel CG4775
gene id: 7227:Dmel_CG4775
uniprot id: Q9VPX8
names: Similarity
messages: Belongs to the UPP synthase family.

7227:Dmel CG1542
gene id: 7227:Dmel_CG1542
uniprot id: Q9V9Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

7227:Dmel CG1575
gene id: 7227:Dmel_CG1575
uniprot id: Q9W3K4
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

7227:Dmel CG1548
gene id: 7227:Dmel_CG1548
uniprot id: Q7K485
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG7507
gene id: 7227:Dmel_CG7507
uniprot id: M9PBQ0
uniprot id: M9PBQ3
uniprot id: M9PE73
uniprot id: M9PEC8
uniprot id: M9PEN4
uniprot id: M9PHG8
uniprot id: P37276
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: cytoskeleton

7227:Dmel CG3544
gene id: 7227:Dmel_CG3544
uniprot id: Q9VPT2
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

7227:Dmel CG8241
gene id: 7227:Dmel_CG8241
uniprot id: A1Z9L3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:18981222, PubMed:24244416). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces (PubMed:24244416).
messages: Lethal. RNAi-mediated knockdown in the germ line results in defective nurse cell morphology.
messages: Nucleus

7227:Dmel CG16865
gene id: 7227:Dmel_CG16865
uniprot id: M9PD43
uniprot id: Q9V412
names: Function
names: Similarity
messages: Belongs to the STEEP1 family.
messages: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity).

7227:Dmel CG7053
gene id: 7227:Dmel_CG7053
uniprot id: Q9VWQ1
names: Similarity
messages: Belongs to the ATG101 family.

7227:Dmel CG3026
gene id: 7227:Dmel_CG3026
uniprot id: Q9V3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

7227:Dmel CG5154
gene id: 7227:Dmel_CG5154
uniprot id: B5RJG0
uniprot id: Q8T0R7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
messages: Glycosylated.
messages: Lacks the typical Glu active site in position 161 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.
messages: Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
messages: Secreted

7227:Dmel CG15088
gene id: 7227:Dmel_CG15088
uniprot id: A1ZBC7
uniprot id: A1ZBC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG5677
gene id: 7227:Dmel_CG5677
uniprot id: A0A0B4K7R1
uniprot id: Q9VCA9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Plays an important role in infection by flaviviruses such as West Nile virus and Dengue virus type 2.
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit twr/SEC11 and three accessory subunits Spase12/SPCS1, Spase25/SPCS2 and Spase22-23/SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
messages: RNAi-mediated knockdown reduces infection by West Nile virus (WNV) and Dengue virus type 2 (DENV-2).

7227:Dmel CG1030
gene id: 7227:Dmel_CG1030
uniprot id: A4V2I1
uniprot id: P09077
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family.
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.

7227:Dmel CG4254
gene id: 7227:Dmel_CG4254
uniprot id: A0A1B2AKQ4
uniprot id: P45594
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Dephosphorylated by protein phosphatase ssh which activates tsr.
messages: Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).
messages: Expressed during all stages of development and peaks in late larval and pupal stages. Expressed in both male and female adults.
messages: Late larval or pupal lethality with mutants showing defects in cytokinesis in both mitotic and meiotic cells, abnormal accumulation of F-actin in mature primary spermatocytes, and defective aster migration where the asters remain in close proximity to each other rather than separating from each other and migrating around the periphery of the nuclear envelope as in the wild type (PubMed:8522587). Failure of terminal filament formation in the ovary at the third larval instar at 25 degrees Celsius but formation occurs at 18 degrees Celsius (PubMed:11175754). Significantly thinner retina than controls, significantly increased F-actin levels in pupal eye disks and defective rhabdomere morphogenesis (PubMed:18423434). Defective mushroom body neuroblast proliferation with newly hatched larvae containing significantly fewer neurons than controls and severe axon growth defects with mutants failing to extend axons beyond the peduncle (PubMed:15572110). RNAi-mediated knockdown in the wing results in increased F-actin levels, altered subcellular location of the transcriptional coactivator yki, strong expression of the yki target genes wg and ex, cell extrusion from the basement membrane, reduced levels of the junction proteins dlg1, arm and shg, up-regulation of Rho1, apoptosis and JNK signaling (PubMed:27041568).
messages: Nucleus matrix
messages: Phosphorylated in vitro by protein kinase LIMK1 (PubMed:20026655). Phosphorylation is required for inactivation of tsr and for cell proliferation and axon growth (PubMed:15572110). Phosphorylation is negatively regulated by the panthothenate kinase fbl which catalyzes the first step in the conversion of panthothenic acid to coenzyme A (PubMed:22912811).
messages: The name 'twinstar' derives from the characteristic aberrant arrangement of asters seen in mutants.
messages: cytoskeleton

7227:Dmel CG5187
gene id: 7227:Dmel_CG5187
uniprot id: Q9VST2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG7902
gene id: 7227:Dmel_CG7902
uniprot id: P22809
uniprot id: Q53YH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-3 homeobox family.
messages: Involved in the determination of cell fates in the dorsal mesoderm.
messages: Is expressed in a segmented pattern in visceral muscle and in a subset of cardiac muscles. Loss of activity results in segmental gaps in midgut visceral muscle.
messages: Nucleus

7227:Dmel CG32262
gene id: 7227:Dmel_CG32262
uniprot id: Q9VZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG31043
gene id: 7227:Dmel_CG31043
uniprot id: A8JR42
uniprot id: Q4AB30
uniprot id: Q9VE13
uniprot id: Q9VE16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

7227:Dmel CG32261
gene id: 7227:Dmel_CG32261
uniprot id: P83293
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: Expression is increased by starvation.
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose.

7227:Dmel CG9796
gene id: 7227:Dmel_CG9796
uniprot id: Q95RA9
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Conjugated to URM1, a ubiquitin-like protein.
messages: Involved in the immune response to bacterial infection.
messages: Lacks the conserved active site CXXC motif that is essential for thiol reductase activity. Its enzyme activity is therefore unsure.
messages: RNAi-mediated knockdown in the fat body or hemocyte of flies infected with the Gram-negative bacterium E.coli results in an increase in bacterial load 24 hours after infection.
messages: Secreted
messages: Up-regulated following injection with the Gram-negative bacterium E.coli. Up-regulation increases between 1 and 6 hours after the injection, then expression remains at a relatively steady level until 72 hours when it is strongly up-regulated.

7227:Dmel CG32706
gene id: 7227:Dmel_CG32706
uniprot id: Q8IRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

7227:Dmel CG4049
gene id: 7227:Dmel_CG4049
uniprot id: Q9W1A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

7227:Dmel CG33100
gene id: 7227:Dmel_CG33100
uniprot id: A0A0B4JDB9
uniprot id: C1C3I0
uniprot id: E1JIV5
uniprot id: Q8T3K5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7227:Dmel CG5590
gene id: 7227:Dmel_CG5590
uniprot id: Q9VB10
names: Subcellular Location Annotation
messages: Peroxisome

7227:Dmel CG15645
gene id: 7227:Dmel_CG15645
uniprot id: Q8IR31
uniprot id: Q9VXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

7227:Dmel CG34125
gene id: 7227:Dmel_CG34125
uniprot id: Q0E8T6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

7227:Dmel CG10520
gene id: 7227:Dmel_CG10520
uniprot id: P22812
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Zygotic expression is highest in late larval development.
messages: Interacts (via Death domain) with pll (via Death domain).
messages: Phosphorylated by pll.
messages: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. Also has a role in pupal pattern formation.

7227:Dmel CG6345
gene id: 7227:Dmel_CG6345
uniprot id: Q9VGZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Potential regulator of CDK5 activity.

7227:Dmel CG3724
gene id: 7227:Dmel_CG3724
uniprot id: M9PIS3
uniprot id: P41572
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

7227:Dmel CG18802
gene id: 7227:Dmel_CG18802
uniprot id: A0A0B4KFG0
uniprot id: Q24451
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked.
messages: Inhibited by swainsonine and by copper sulfate.

7227:Dmel CG33718
gene id: 7227:Dmel_CG33718
uniprot id: G4LTX1
uniprot id: Q8IQ56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

7227:Dmel CG6705
gene id: 7227:Dmel_CG6705
uniprot id: P40689
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. At early blastoderm stage, forms a symmetrical concentration gradient at the poles on the surface of the devitellinized embryo.
messages: Probable ligand that binds to the torso receptor. Implicated in a receptor tyrosine kinase signaling pathway that specifies terminal cell fate.
messages: Restricted to specialized categories of follicle cells localized at the poles of the egg chamber.
messages: Secreted

7227:Dmel CG11968
gene id: 7227:Dmel_CG11968
uniprot id: Q9VHJ4
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

7227:Dmel CG7339
gene id: 7227:Dmel_CG7339
uniprot id: Q9VTL6
names: Similarity
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.

7227:Dmel CG12501
gene id: 7227:Dmel_CG12501
uniprot id: Q9V8Y7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG11241
gene id: 7227:Dmel_CG11241
uniprot id: A8E6R2
uniprot id: Q9VNR7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

7227:Dmel CG32402
gene id: 7227:Dmel_CG32402
uniprot id: E5AJG9
uniprot id: P82983
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG2328
gene id: 7227:Dmel_CG2328
uniprot id: F9W320
uniprot id: P06602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the even-skipped homeobox family.
messages: May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.
messages: Nucleus

7227:Dmel CG3683
gene id: 7227:Dmel_CG3683
uniprot id: Q9W125
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane

7227:Dmel CG4390
gene id: 7227:Dmel_CG4390
uniprot id: Q7KSB5
uniprot id: Q9VDP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

7227:Dmel CG6244
gene id: 7227:Dmel_CG6244
uniprot id: Q7KUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

7227:Dmel CG6560
gene id: 7227:Dmel_CG6560
uniprot id: Q9VD64
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7227:Dmel CG9485
gene id: 7227:Dmel_CG9485
uniprot id: E1JGQ5
uniprot id: Q7KVP4
uniprot id: Q86BS7
uniprot id: Q9W2H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

7227:Dmel CG9307
gene id: 7227:Dmel_CG9307
uniprot id: Q9VFR3
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG4685
gene id: 7227:Dmel_CG4685
uniprot id: Q9VBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

7227:Dmel CG17514
gene id: 7227:Dmel_CG17514
uniprot id: Q7PLL6
names: Similarity
messages: Belongs to the GCN1 family.

7227:Dmel CG8612
gene id: 7227:Dmel_CG8612
uniprot id: Q9V3E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

7227:Dmel CG6424
gene id: 7227:Dmel_CG6424
uniprot id: Q0E938
names: Similarity
messages: Belongs to the FAM13 family.

7227:Dmel CG9086
gene id: 7227:Dmel_CG9086
uniprot id: M9NFA7
uniprot id: Q9VX91
names: Domain
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
messages: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

7227:Dmel CG31718
gene id: 7227:Dmel_CG31718
uniprot id: M9PCT4
uniprot id: Q8IPB8
names: Similarity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

7227:Dmel CG6499
gene id: 7227:Dmel_CG6499
uniprot id: Q9VFA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG8611
gene id: 7227:Dmel_CG8611
uniprot id: Q86B47
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Probable ATP-dependent RNA helicase.

7227:Dmel CG1671
gene id: 7227:Dmel_CG1671
uniprot id: Q7JQT9
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG6202
gene id: 7227:Dmel_CG6202
uniprot id: O18405
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion.
messages: Endoplasmic reticulum membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

7227:Dmel CG32442
gene id: 7227:Dmel_CG32442
uniprot id: B7Z097
uniprot id: Q8IPT3
uniprot id: Q8SYH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

7227:Dmel CG1506
gene id: 7227:Dmel_CG1506
uniprot id: Q9V9R3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

7227:Dmel CG8282
gene id: 7227:Dmel_CG8282
uniprot id: M9NDI3
uniprot id: Q9VLQ9
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

7227:Dmel CG8798
gene id: 7227:Dmel_CG8798
uniprot id: Q7KUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by stabilizing the mitochondrial TFAM:mtDNA ratio via selective degradation of TFAM.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

7227:Dmel CG14231
gene id: 7227:Dmel_CG14231
uniprot id: M9NHD5
uniprot id: Q9VWD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

7227:Dmel CG9253
gene id: 7227:Dmel_CG9253
uniprot id: Q9VIF6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Mutants show hypotrophy of the nucleolus.
messages: Part of a translational control module, also containing ath/DHX33 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation (PubMed:35413237). With atos, adjusts transcription and translation of a subset of OXPHOS genes in marophages to increase mitochondrial bioenergetics and allow tissue invasion (PubMed:35319107).
messages: nucleolus

7227:Dmel CG6836
gene id: 7227:Dmel_CG6836
uniprot id: B5RJ74
uniprot id: Q9VVV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter.

7227:Dmel CG33887
gene id: 7227:Dmel_CG33887
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG2875
gene id: 7227:Dmel_CG2875
uniprot id: Q9W4R1
uniprot id: Q9W4R2
names: Similarity
messages: Belongs to the CBF/MAK21 family.

7227:Dmel CG3313
gene id: 7227:Dmel_CG3313
uniprot id: Q9VGE3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat DCAF12 family.
messages: Cytoplasm
messages: Embryonic lethality.
messages: In larvae, expressed in neurons, glia and muscles.
messages: Nucleus
messages: Presynapse
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:30670470, PubMed:31857346). Required for synaptic function and plasticity at larval neuromuscular junctions (NMJs) by promoting neurotransmitter release (PubMed:30670470). The DCX(DCAF12) complex catalyzes ubiquitination and degradation of yorkie (yki), thereby regulating the Hippo/SWH (Sav/Wts/Hpo) signaling pathway (PubMed:31857346). Acts as a regulator of tissue growth during development: required for the apoptotic elimination of supernumerary cells during metamorphosis (PubMed:26972874).
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) protein ligase complex.

7227:Dmel CG33893
gene id: 7227:Dmel_CG33893
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG33289
gene id: 7227:Dmel_CG33289
uniprot id: M9NDF3
uniprot id: Q7KTW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG2259
gene id: 7227:Dmel_CG2259
uniprot id: A4V448
uniprot id: Q9W3K5
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.
messages: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.

7227:Dmel CG9231
gene id: 7227:Dmel_CG9231
uniprot id: Q9VW12
uniprot id: X2JGV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

7227:Dmel CG3160
gene id: 7227:Dmel_CG3160
uniprot id: Q9W495
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins.

7227:Dmel CG8916
gene id: 7227:Dmel_CG8916
uniprot id: E1JJA9
uniprot id: Q9VXL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG14164
gene id: 7227:Dmel_CG14164
uniprot id: Q9VT67
names: Miscellaneous
names: Similarity
messages: Belongs to the LSM12 family.
messages: This protein is produced by a bicistronic gene which also produces the CG6709 protein from a non-overlapping reading frame.

7227:Dmel CG3051
gene id: 7227:Dmel_CG3051
uniprot id: O18645
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

7227:Dmel CG31065
gene id: 7227:Dmel_CG31065
uniprot id: A8JPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG4583
gene id: 7227:Dmel_CG4583
uniprot id: A8JR46
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5300
gene id: 7227:Dmel_CG5300
uniprot id: E1JHE1
uniprot id: Q9VKW4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG6038
gene id: 7227:Dmel_CG6038
uniprot id: Q9VTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG9752
gene id: 7227:Dmel_CG9752
uniprot id: Q9W2I2
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

7227:Dmel CG1965
gene id: 7227:Dmel_CG1965
uniprot id: Q9VI54
names: Similarity
messages: Belongs to the GCF family.

7227:Dmel CG4457
gene id: 7227:Dmel_CG4457
uniprot id: A0A1B2AKI4
uniprot id: P49963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: Srp72, Srp68, Srp54, Srp19, Srp14 and Srp9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of Srp54 to the SRP complex (By similarity).
messages: Cytoplasm
messages: nucleolus

7227:Dmel CG6939
gene id: 7227:Dmel_CG6939
uniprot id: Q7KSP6
uniprot id: Q9VGH9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7227:Dmel CG17322
gene id: 7227:Dmel_CG17322
uniprot id: Q9VJ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG4385
gene id: 7227:Dmel_CG4385
uniprot id: P42519
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in embryos and larvae.
messages: Golgi apparatus membrane
messages: In the larval eye disk, expression is first seen at the morphogenetic furrow, then in the developing R2, R5, and R8 cells as well as in the posterior clusters of the disk in additional R cells.
messages: Interacts with Spitz via the lumenal domain and mediates its transport to the Golgi.
messages: Involved in EGF receptor signaling. Has an early role in photoreceptor development. Interacts with the receptor torpedo in the eye.

7227:Dmel CG1633
gene id: 7227:Dmel_CG1633
uniprot id: Q9V3P0
uniprot id: X2JF59
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family.
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Conjugated to URM1, a ubiquitin-like protein.
messages: Cytoplasm
messages: Highly expressed during embryogenesis, weakly expressed during larval stages.
messages: Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (By similarity).
messages: Results in reduced resistance to oxidative stress (PubMed:26715182). Simultaneous knockout of Urm1 restores normal sensitivity to oxidative stress (PubMed:26715182).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin (By similarity). As a reducing substrate, thioredoxin 2 is preferred over thioredoxin 1 (PubMed:11877442).
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

7227:Dmel CG12389
gene id: 7227:Dmel_CG12389
uniprot id: Q7KN61
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

7227:Dmel CG14977
gene id: 7227:Dmel_CG14977
uniprot id: A0A1B3Q3M2
uniprot id: M9PBM4
uniprot id: Q9VZL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR4 family.
messages: Lysosome
messages: Part of the Ragulator complex composed of Lamtor3, Lamtor2, CG14184, CG14812, and Lamtor4.
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.

7227:Dmel CG18005
gene id: 7227:Dmel_CG18005
uniprot id: Q9VHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

7227:Dmel CG13579
gene id: 7227:Dmel_CG13579
uniprot id: A0A0B4KG01
uniprot id: Q9W167
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG30293
gene id: 7227:Dmel_CG30293
uniprot id: Q8MLW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG6201
gene id: 7227:Dmel_CG6201
uniprot id: Q9VKJ8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 39 family.
messages: Essential lysosomal hydrolase responsible for the degradation of the glycosaminoglycans (GAG) heparan sulfate and dermatan sulfate (Probable). Required for lysosome function and autophagy (PubMed:35011691). Consequently, has an essential role in the development, maintenance and function of various cells, tissues, and organs, including the muscles and the central nervous system (CNS) (PubMed:35011691).
messages: Lysosome
messages: RNAi-mediated knockdown results in dysregulated glycolysis and lipogenesis, and is pupal lethal (PubMed:35011691). RNAi-mediated knockdown causes the incorrect acidification of lysosomes leading to dysfunctional lysosome-autophagosome fusion and consequently, blocks autophagy flux (PubMed:35011691). RNAi-mediated knockdown results in a significant increase in the number and size of lysosomes in the brain (PubMed:35011691). Expression levels of genes involved in glycolysis (Pfk, Tpi and Ldh) and lipogenesis (ACC) are increased (PubMed:35011691). Conditional RNAi-mediated knockdown causes developmental defects leading to premature death at different stages, depending on the tissue and on the extent of the expression reduction (PubMed:35011691). RNAi-mediated knockdown in muscles results in complete lethality at the pupal stage, knockdown in glial cells results in partial lethality at the pupal stage (about 73% of flies reach the adult stage), whereas knockdown in neurons is not lethal (PubMed:35011691). Conditional RNAi-mediated knockdown in the muscles results in a significant increase in the number and size of lysosomes in the muscles (PubMed:35011691). RNAi-mediated knockdown in glial cells and also in neurons, causes an age-dependent climbing decline and increases adult lifespan (PubMed:35011691).

7227:Dmel CG3861
gene id: 7227:Dmel_CG3861
uniprot id: Q9W401
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Mutation of kdn causes a behavioral mutation ('bang sensitivity' = temporarily paralysis in response to a physical jolt). Flies lacking kdn exhibit alterations in neuronal firing patterns in the giant fiber (GF) pathway.
messages: Plays a role in controlling neuronal activity and seizure susceptibility.

7227:Dmel CG6140
gene id: 7227:Dmel_CG6140
uniprot id: Q9VTI5
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

7227:Dmel CG46339
gene id: 7227:Dmel_CG46339
uniprot id: A0A0B4K7L8
uniprot id: A0A0B4KH77
uniprot id: A8JRD7
uniprot id: Q9VBA3
names: Similarity
messages: Belongs to the peptidase M1 family.

7227:Dmel CG32206
gene id: 7227:Dmel_CG32206
uniprot id: Q9VVY7
uniprot id: R9PY60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG6701
gene id: 7227:Dmel_CG6701
uniprot id: A1Z9K0
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

7227:Dmel CG8669
gene id: 7227:Dmel_CG8669
uniprot id: M9PBF8
uniprot id: Q9NIR3
uniprot id: Q9VID3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG42598
gene id: 7227:Dmel_CG42598
uniprot id: D2A6L3
names: Similarity
messages: Belongs to the polysaccharide monooxygenase AA13 family.

7227:Dmel CG42247
gene id: 7227:Dmel_CG42247
uniprot id: M9PF94
uniprot id: M9PFN2
uniprot id: Q9VUI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

7227:Dmel CG4059
gene id: 7227:Dmel_CG4059
uniprot id: A0A0S0WH29
uniprot id: M9NFK2
uniprot id: P33244
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Expression in the parasegmental primordia of the embryonic blastoderm.
messages: First appears in blastoderm embryos. It is absent in subsequent embryo stages, and then reappears in late embryogenesis to be found in larvae, pupae and adults.
messages: Ftz-like pair-rule cuticular defects.
messages: Monomer; forms a complex with ftz.
messages: Nucleus

7227:Dmel CG14728
gene id: 7227:Dmel_CG14728
uniprot id: Q9VGH1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Complex coexpression pattern of dib (disembodied) and sad (shade) in the early embryo that restricts to the prothoracic gland cells of the developing ring gland during late embryogenesis. In larvae and adult, coexpression is seen in prothoracic gland and follicle cells of the ovary. In adults, coexpression is seen in the follicle cells, sad only is expressed in nurse cells.
messages: Member of the Halloween gene group.
messages: Mitochondrion membrane
messages: Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.

7227:Dmel CG31173
gene id: 7227:Dmel_CG31173
uniprot id: Q9VD74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily.
messages: Cell membrane
messages: In larvae, is expressed in neurons of the posterior pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG15520
gene id: 7227:Dmel_CG15520
uniprot id: A0A1B2AIW9
uniprot id: Q9NIP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pyrokinin family.
messages: CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor (PubMed:12177421, PubMed:12459185). CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide (PubMed:11959669). CAP-3 is a ligand for the PK1-R G-protein coupled receptor (PubMed:16054112).
messages: In larvae, the precursor peptide is exclusively present in a single pair of neuroendocrine cells in the labial neuromere (subesophageal ganglion) and three pairs of cells in the ventral ganglion abdominal neuromeres.
messages: Secreted

7227:Dmel CG2934
gene id: 7227:Dmel_CG2934
uniprot id: Q9W4P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

7227:Dmel CG3011
gene id: 7227:Dmel_CG3011
uniprot id: B7Z0X1
uniprot id: Q9W457
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

7227:Dmel CG15408
gene id: 7227:Dmel_CG15408
uniprot id: Q9VQP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG5189
gene id: 7227:Dmel_CG5189
uniprot id: A0A1B2AJR6
uniprot id: Q9V8I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GAMAD family.
messages: Part of the Ragulator complex composed of Lamtor3, Lamtor2, CG14184, CG14812, and Lamtor4.
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.

7227:Dmel CG33861
gene id: 7227:Dmel_CG33861
uniprot id: Q4AB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG31278
gene id: 7227:Dmel_CG31278
uniprot id: A0A0B4LI27
uniprot id: Q9VGY2
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

7227:Dmel CG1395
gene id: 7227:Dmel_CG1395
uniprot id: A0A0B4KI54
uniprot id: P20483
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity.

7227:Dmel CG7427
gene id: 7227:Dmel_CG7427
uniprot id: M9NDR9
uniprot id: M9NEA3
uniprot id: M9PI67
uniprot id: Q9VUQ8
names: Function
names: Subunit
messages: Interacts with the cullin cul-5.
messages: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

7227:Dmel CG6627
gene id: 7227:Dmel_CG6627
uniprot id: Q9VKN8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG9541
gene id: 7227:Dmel_CG9541
uniprot id: M9PCF9
uniprot id: Q9VLG2
names: Similarity
messages: Belongs to the adenylate kinase family.

7227:Dmel CG10843
gene id: 7227:Dmel_CG10843
uniprot id: Q9V559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG5348
gene id: 7227:Dmel_CG5348
uniprot id: A0A0B4K889
uniprot id: A1ZAJ4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3036
gene id: 7227:Dmel_CG3036
uniprot id: Q9VR44
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5532
gene id: 7227:Dmel_CG5532
uniprot id: A0A0B4LGA1
uniprot id: Q9W1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Membrane

7227:Dmel CG5380
gene id: 7227:Dmel_CG5380
uniprot id: D5SHN0
uniprot id: Q9VD25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

7227:Dmel CG6456
gene id: 7227:Dmel_CG6456
uniprot id: Q9VVF7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: All five Drostatin-B peptides activate SPR with comparable efficiency, however Drostatin-B4 is a slightly more potent ligand.
messages: Expressed throughout development, with higher expression in larvae than in embryos (at protein level) (PubMed:11181081). Higher expression in males than females, with strongest expression at the third instar larval stage (PubMed:20458515).
messages: In both sexes RNA-mediated knockdown results in decreased day- and night-time sleep due to reduced sleep-bout duration. The number of sleep-bouts is not affected.
messages: In larvae, strongly expressed in the midgut region before and in between the copper cells, and in a group of cells in the posterior part of the larval midgut (PubMed:11181081, PubMed:19319573). Expressed in the neurons of many areas including the subesophageal ganglion/tritocerebrum (SOG), olfactory glomeruli, lateral ventral protocerebrum, mushroom body, the optic lobe medulla and in the antennal lobes (PubMed:11181081, PubMed:20308537,PubMed:21174124).
messages: Ligand for the sex peptide receptor (SPR) (PubMed:20308537, PubMed:20458515, PubMed:25333796). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat (PubMed:25333796). May also have a regulatory role in gut motility (PubMed:11181081).
messages: Secreted
messages: Up-regulated by sleep deprivation.

7227:Dmel CG1963
gene id: 7227:Dmel_CG1963
uniprot id: O76454
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

7227:Dmel CG30396
gene id: 7227:Dmel_CG30396
uniprot id: P58962
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG31809
gene id: 7227:Dmel_CG31809
uniprot id: Q8INZ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG30021
gene id: 7227:Dmel_CG30021
uniprot id: A0A0B4LF49
uniprot id: A1Z8G0
uniprot id: B7YZF0
uniprot id: Q8T5S9
names: Similarity
messages: Belongs to the MAGUK family.

7227:Dmel CG32540
gene id: 7227:Dmel_CG32540
uniprot id: Q7M3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG9674
gene id: 7227:Dmel_CG9674
uniprot id: M9NFH8
uniprot id: M9PCU8
uniprot id: Q9VVA4
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

7227:Dmel CG7067
gene id: 7227:Dmel_CG7067
uniprot id: O76464
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP.
messages: Expressed in embryo and adult.
messages: Homotetramer.
messages: In the N-terminal section; belongs to the UPF0012 family.

7227:Dmel CG8380
gene id: 7227:Dmel_CG8380
uniprot id: A0A0B4KEX2
uniprot id: Q7K4Y6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 10-fold less sensitive to cocaine than mammalian dopamine transporter SLC6A3.
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Cell membrane
messages: Expression is restricted to dopaminergic neurons in the central nervous system.
messages: Low levels in 0-4 hour embryos with strong expression in late embryos at 12-24 hours and during larval development. Expression decreases during pupal development and increases again in adult flies with heads showing higher levels than bodies.
messages: Membrane
messages: No effect on fertility or longevity but mutants display longer periods of daily activity than controls, reduced rest, enhanced sensitivity to mechanical stimuli when inactive and decreased rest rebound in response to rest deprivation (PubMed:16093388). Impaired aversive olfactory memory due to excessive dopaminergic signaling (PubMed:25232310). RNAi-mediated knockdown in neurons causes significant reduction in the sleep-like rest state with total daily resting periods decreased to about half of that of control flies (PubMed:25232310).
messages: Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245). Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774). Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310).

7227:Dmel CG7094
gene id: 7227:Dmel_CG7094
uniprot id: Q9VJC2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG6605
gene id: 7227:Dmel_CG6605
uniprot id: M9NDR2
uniprot id: M9PDB8
uniprot id: M9PDL9
uniprot id: P16568
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BicD family.
messages: Expressed maternally and zygotically (PubMed:2576013). Expressed during oogenesis and throughout development (PubMed:2576013, PubMed:11546740).
messages: In ovaries, expressed in oocyte and nurse cells.
messages: Interacts (via C-terminal domain) with Rab6.
messages: Mutant embryos show Nanos mislocalization and thus bicaudal development (PubMed:2590944). RNAi-mediated knockdown results in sterility and egg chamber defects including loss of annulate lamellae (PubMed:31626769).
messages: This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).
messages: cytoskeleton

7227:Dmel CG5703
gene id: 7227:Dmel_CG5703
uniprot id: Q9VX36
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

7227:Dmel CG5798
gene id: 7227:Dmel_CG5798
uniprot id: Q9VDD8
names: Similarity
messages: Belongs to the peptidase C19 family.

7227:Dmel CG9591
gene id: 7227:Dmel_CG9591
uniprot id: Q9VFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 5 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane

7227:Dmel CG8862
gene id: 7227:Dmel_CG8862
uniprot id: Q7JXB9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7227:Dmel CG9353
gene id: 7227:Dmel_CG9353
uniprot id: Q9W2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

7227:Dmel CG8237
gene id: 7227:Dmel_CG8237
uniprot id: Q7JXC6
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG15634
gene id: 7227:Dmel_CG15634
uniprot id: Q9VR19
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expression is developmentally restricted, peaks at the blastoderm stage (2-4 hours) and then disappears (at protein level).
messages: Nucleus
messages: The heterotrimeric Elba complex consists of Elba1, Elba2 and Elba3.
messages: The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2 (PubMed:23240086).

7227:Dmel CG9410
gene id: 7227:Dmel_CG9410
uniprot id: Q8MLL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

7227:Dmel CG3942
gene id: 7227:Dmel_CG3942
uniprot id: Q9VGB2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7227:Dmel CG31092
gene id: 7227:Dmel_CG31092
uniprot id: A0A0B4KGZ9
uniprot id: A0A0B4KH38
uniprot id: A8JRC4
uniprot id: A8JRC7
uniprot id: Q6NN57
uniprot id: Q7YTZ6
uniprot id: Q7YU01
uniprot id: Q86B77
uniprot id: Q9VBN2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

7227:Dmel CG6702
gene id: 7227:Dmel_CG6702
uniprot id: P41044
names: Similarity
names: Tissue Specificity
messages: Belongs to the calbindin family.
messages: Expressed in a large number of neuron of the brain and the thoracic ganglion as well as in two small muscles of the thorax.

7227:Dmel CG3332
gene id: 7227:Dmel_CG3332
uniprot id: Q8IQ02
uniprot id: Q9VQN3
uniprot id: X2J8I0
uniprot id: X2JD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG1659
gene id: 7227:Dmel_CG1659
uniprot id: Q540Y4
uniprot id: Q9XYQ2
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).
messages: Belongs to the PDE6D/unc-119 family.
messages: Expressed in nervous system.
messages: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization.

7227:Dmel CG33527
gene id: 7227:Dmel_CG33527
uniprot id: Q6IGX9
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Ligand for the neuropeptide SIFamide receptor (PubMed:16378592). Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541). Also involved in promoting sleep (PubMed:24658384).
messages: Probably cloning artifact.
messages: RNAi-mediated knockdown in SIFa-expressing neurons causes normal male sexual activity towards virgin females but also vigorous courtship directed at other males and also leads to female hyper-receptivity with a dramatic decrease in copulation time (PubMed:17126293). It also causes reduced sleep and shortened sleep bout length (PubMed:24658384).
messages: Secreted
messages: Strongly expressed in two pairs of neurons in the pars intercerebralis (at protein level).

7227:Dmel CG31034
gene id: 7227:Dmel_CG31034
uniprot id: C0HKF7
uniprot id: C0HKF8
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Abundantly expressed in the larval gut.
messages: Belongs to the peptidase S1 family.
messages: Expression appears at the late embryo stage and continues to increase in abundance throughout the larval stage. No expression in pupae but is expressed in the adult.
messages: Major function may be to aid in digestion.

7227:Dmel CG10001
gene id: 7227:Dmel_CG10001
uniprot id: D6W4V7
uniprot id: Q9NBC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7227:Dmel CG16799
gene id: 7227:Dmel_CG16799
uniprot id: A1ZBX6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7227:Dmel CG43657
gene id: 7227:Dmel_CG43657
uniprot id: Q0KHU0
uniprot id: Q9VZ45
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7227:Dmel CG6988
gene id: 7227:Dmel_CG6988
uniprot id: P54399
uniprot id: X2JGP4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Expressed in all head and body tissues.
messages: Homodimer.
messages: Participates in the folding of proteins containing disulfide bonds.
messages: Ubiquitously expressed during development.

7227:Dmel CG3338
gene id: 7227:Dmel_CG3338
uniprot id: Q9VQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

7227:Dmel CG10938
gene id: 7227:Dmel_CG10938
uniprot id: Q95083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG6936
gene id: 7227:Dmel_CG6936
uniprot id: E1JHX3
uniprot id: O97148
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Agonists of mth share minimal sequence homology, suggesting a remarkable promiscuity of mth for activation.
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature and dietary paraquat, a free-radical generator.
messages: Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up-regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro.
messages: Membrane

7227:Dmel CG11010
gene id: 7227:Dmel_CG11010
uniprot id: M9PI48
uniprot id: Q9VU20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7227:Dmel CG6927
gene id: 7227:Dmel_CG6927
uniprot id: Q9W4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

7227:Dmel CG10082
gene id: 7227:Dmel_CG10082
uniprot id: Q961X0
uniprot id: Q9W2E9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7227:Dmel CG17100
gene id: 7227:Dmel_CG17100
uniprot id: Q9VGZ5
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Contains a degenerate basic motif not likely to bind DNA.
messages: Expressed in adult brain where it is detected in the dorsal lateral neurons, small and large ventral lateral neurons and dorsal neurons 1, 2 and 3 (at protein level) (PubMed:17578908). Expressed at constant levels in a 12 hour light/12 hour day cycle (at protein level) (PubMed:27814361). Strongly expressed in pacemaker neurons (PubMed:17578907). In adults, mRNA expression oscillates in a circadian manner with a peak at around 14 h Zeitgeber time (PubMed:17578907). mRNA levels oscillate in a rhythmic manner in both 12 hour light/12 hour dark and constant dark conditions with a morning peak around the time of lights-on and an evening peak around the time of lights-off in light/dark conditions (PubMed:17555964, PubMed:17578908, PubMed:18375860). During stage 8 of embryonic development, expressed in the anterior and posterior midgut primordia and expression in the gut continues throughout embryonic development (PubMed:11102367). During germ band retraction, expression is initiated in many tissues in a prominent segmentally repeated pattern (PubMed:11102367). Later, expression is ubiquitous but has higher levels in segmentally repeated clusters of cells (PubMed:11102367). Expression is also found in cells of the amnioserosa, in the head region, in posterior spiracles and in tracheal trees (PubMed:11102367).
messages: Nucleus
messages: Plays a role in the regulation of circadian rhythms (PubMed:17555964, PubMed:17578907, PubMed:17578908, PubMed:27814361). Transcriptional repressor which inhibits Clock-mediated transcriptional activation by binding to E boxes in the promoters of Clock target genes and repressing their transcription (PubMed:17555964, PubMed:17578907, PubMed:17578908, PubMed:27814361). E box binding activity is time-dependent with higher binding activity seen in the early morning (zeitgeber time 2) than early evening (zeitgeber time 14) and is dependent on the presence of the circadian protein per (PubMed:27814361). It is likely that per binds to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361). Negatively regulates its own expression (PubMed:17578908, PubMed:18375860).
messages: Strong circadian locomotor phenotype with most mutants being arrhythmic after 4 days in constant darkness and displaying a long period in both light/dark and constant dark conditions (PubMed:17578907). Delayed evening activity peak in light/dark conditions and robust 26.5 hour rhythms for at least 10 days in constant darkness (PubMed:18375860). Reduced circadian oscillation of Clk target genes per, tim, vri and Pdp1 (PubMed:17578907, PubMed:18375860). RNAi-mediated knockdown results in a lengthened circadian period (PubMed:17555964, PubMed:17578908).
messages: The name 'clockwork orange' is based on the Anthony Burgess novel of the same name and derives from the potential clock function and the presence of an Orange domain.

7227:Dmel CG9300
gene id: 7227:Dmel_CG9300
uniprot id: Q9VW10
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG4593
gene id: 7227:Dmel_CG4593
uniprot id: Q9W3T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

7227:Dmel CG7360
gene id: 7227:Dmel_CG7360
uniprot id: Q9VDV3
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUP58 family.
messages: Component of the nuclear pore complex (PubMed:15086791). Interacts with Nup54 (PubMed:33856346). Interacts (via C-terminus) with fs(1)Yb; this interaction occurs in a RNA-independent manner (PubMed:33856346). Interacts with sbr/nxf1 (PubMed:33856346). Interacts with Nxt1 (PubMed:33856346).
messages: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (PubMed:15086791). Together with Nup54, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346).
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: Expressed during embryonic development (at protein level).
messages: O-glycosylated; contains O-GlcNAc (PubMed:15086791, PubMed:24706800). O-GlcNAcylation increases with increasing ambient temperature (PubMed:24706800).
messages: nuclear pore complex

7227:Dmel CG15211
gene id: 7227:Dmel_CG15211
uniprot id: Q9VZ71
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG31675
gene id: 7227:Dmel_CG31675
uniprot id: Q8SXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG7440
gene id: 7227:Dmel_CG7440
uniprot id: Q9VWM1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8094
gene id: 7227:Dmel_CG8094
uniprot id: Q7JYW9
names: Similarity
messages: Belongs to the hexokinase family.

7227:Dmel CG12892
gene id: 7227:Dmel_CG12892
uniprot id: A1Z898
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7623
gene id: 7227:Dmel_CG7623
uniprot id: H0RNN2
uniprot id: Q9VEI3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Expressed both maternally and zygotically.
messages: Expressed throughout embryogenesis. During oogenesis, it is expressed strongly in the nurse cells of the germline. Maternally expressed at the syncytial blastoderm stage. Zygotically expressed, from after germ-band elongation in the invaginating salivary gland placodes. Remains expressed predominantly in this tissue throughout embryogenesis, but low-level expression may also be present throughout the embryo.
messages: Flies display defects in wingless (wg) and hedgehog (hh) signaling, probably due to the lack of sulfation of glycosaminoglycans by sulfotransferases such as sfl.
messages: Golgi apparatus membrane
messages: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Required for the dorsoventral patterning, suggesting that it mediates the transport of the sulfate donor required for the sulfotransferase activity of pip (pipe).
messages: Membrane

7227:Dmel CG1622
gene id: 7227:Dmel_CG1622
uniprot id: M9PHQ4
uniprot id: Q9VYE9
uniprot id: X2JF51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

7227:Dmel CG9396
gene id: 7227:Dmel_CG9396
uniprot id: Q9VHB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG8887
gene id: 7227:Dmel_CG8887
uniprot id: Q9VW15
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Component of a large multiprotein complex distinct from complexes containing ash2 or brm (PubMed:9735357). Interacts (via SET domain) with trx (via SET domain) (PubMed:10454589, PubMed:10656681). Interacts with nej/cbp (PubMed:11094082).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed both maternally and zygotically. During oogenesis it accumulates in the nurse cells of developing egg chambers.
messages: Expressed throughout development but is present at higher levels during the embryonic and pupal stages than during the larval stages. During the larval stages it accumulates primarily in imaginal disks.
messages: Nucleus
messages: The SET domain is sufficient for methyltransferase activity.
messages: Trithorax group (TrxG) protein that has histone methyltransferase activity (PubMed:13679578, PubMed:16882982). Specifically trimethylates 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:13679578, PubMed:16882982). TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active (PubMed:15031712).
messages: Was reported to trimethylate H3 'Lys-9' and H4 'Lys-20' (PubMed:12397363). Was also reported to bind non-coding RNAs of trithorax response element (TRE) (PubMed:16497925). However, both papers were retracted because some data, results and conclusions are not reliable.

7227:Dmel CG13968
gene id: 7227:Dmel_CG13968
uniprot id: Q9VIQ0
names: Developmental Stage
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NPY family.
messages: Expressed throughout development from embryo to adult.
messages: Flies overexpressing sNPF are heavier and bigger than wild-type. But loss-of-function flies are not smaller than wild-type.
messages: Plays a role in controlling food intake and regulating body size.
messages: Probable cloning artifact.
messages: Secreted
messages: Stage 17 embryos show expression in the two brain hemispheres (neural cells located in the dorsal posterior region), the connected ventral ganglion (pairs of neural cells along the ventral midline) and the peripheral nervous system (expressed in the antennal-maxillary sensory cells). In the brain hemispheres of the feeding third instar larva, expression in neural cells is located in the dorsal-anterior region of the protocerebrum. In the larval ventral ganglion, expression is seen in the neural cells located in the subesophagial region, along the ventral midline and in thoracic and abdominal segments. In the adult brain, expression is seen in the medulla and the mushroom body calyx (at protein level).

7227:Dmel CG7523
gene id: 7227:Dmel_CG7523
uniprot id: Q9VEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Membrane

7227:Dmel CG40129
gene id: 7227:Dmel_CG40129
uniprot id: E1JGX2
uniprot id: P32865
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Specifically phosphorylates the activated forms of G protein-coupled receptors.

7227:Dmel CG5842
gene id: 7227:Dmel_CG5842
uniprot id: M9PI57
uniprot id: Q9VUD5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG30488
gene id: 7227:Dmel_CG30488
uniprot id: A0A0B4K7N3
uniprot id: Q4V3Y4
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5427
gene id: 7227:Dmel_CG5427
uniprot id: Q9VK84
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG3460
gene id: 7227:Dmel_CG3460
uniprot id: O46050
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG10171
gene id: 7227:Dmel_CG10171
uniprot id: Q8IQJ7
uniprot id: Q9VU64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

7227:Dmel CG15555
gene id: 7227:Dmel_CG15555
uniprot id: Q9V9Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG18377
gene id: 7227:Dmel_CG18377
uniprot id: A0A0B4K7M1
uniprot id: Q9V5L3
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Intron retention.
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG32601
gene id: 7227:Dmel_CG32601
uniprot id: B6VQA0
names: Similarity
messages: Belongs to the NAC-beta family.

7227:Dmel CG17669
gene id: 7227:Dmel_CG17669
uniprot id: A1ZB91
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Displays impaired motility of cilia/flagella (PubMed:34553759). Adult males are infertile due to immotile sperm with flagella that lack dynein arms and display axoneme disruption (PubMed:34553759). However, the testes appear normal in shape and contain elongating flagellar bundles of spermatids (PubMed:34553759). Larvae fail to react to tone stimulus due to defective auditory/vibration mechanotransduction (PubMed:34553759). RNAi-mediated knockdown in the sensory neurons of females results in uncoordinated locomotion during climbing (PubMed:34553759).
messages: Dynein axonemal particle
messages: Expressed in mechanosensory chordotonal (Ch) neurons, spermatocytes and spermatids (at protein level).
messages: In stage 16 embryo, restricted to all differentiating mechanosensory chordotonal (Ch) neurons (lch5, v'ch1, and vchAB) (at protein level) (PubMed:34553759). In pupae, expression is restricted to the neuronal cell bodies and dendrite inner segments of Ch neurons within the Johnston's organ (at protein level) (PubMed:34553759).
messages: Required for the assembly of axonemal inner and outer dynein arms (PubMed:34553759). Involved in the cytoplasmic preassembly of dyneins into complexes before their transport into cilia (PubMed:34553759). Essential for the development of axonemal dynein motors in the sensory cilium of mechanosensory chordotonal (Ch) neurons and sperm flagellum, and consequently, is required for the mechanotransduction process of hearing and sperm mobility (PubMed:34553759).

7227:Dmel CG6472
gene id: 7227:Dmel_CG6472
uniprot id: A1ZAL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG34389
gene id: 7227:Dmel_CG34389
uniprot id: A8JR05
uniprot id: Q9VFK2
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG5889
gene id: 7227:Dmel_CG5889
uniprot id: E1JIZ4
uniprot id: E1JIZ5
uniprot id: Q9VB69
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

7227:Dmel CG9701
gene id: 7227:Dmel_CG9701
uniprot id: Q9VV98
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

7227:Dmel CG12366
gene id: 7227:Dmel_CG12366
uniprot id: A8E6L6
uniprot id: Q9V6X7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 65 family.
messages: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines (PubMed:12909620). Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer (By similarity). Plays a crucial role in Notch signaling (PubMed:12917292, PubMed:12909620, PubMed:17329366). Initial fucosylation of Notch/N by O-fut1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats (PubMed:12909620). This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Serrate/Ser (PubMed:12909620, PubMed:12917292). Also required for the transport of Notch/N to the early endosome (PubMed:17329366).
messages: Endoplasmic reticulum
messages: Expressed both maternally and zygotically.
messages: Interacts with N (via its EGF domains); the interaction is required for the endocyctic transport of N.

7227:Dmel CG4164
gene id: 7227:Dmel_CG4164
uniprot id: Q9VPQ2
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: In the testes, detected at low levels in somatic hub cells, cyst stem cells and the apical tip (at protein level). Levels in the testes decrease with age (at protein level). Expressed at low levels in hub cells, cyst stem cells and germline stem cells, and at high levels in spermatocytes and cyst cells.
messages: Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE-cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells.
messages: Males are sterile and display an age-dependent decrease in testes size resulting from a gradual loss in somatic hub cell structure and a decrease in the number of germline stem cells. Hub cells frequently do not localize to the apical tip and are instead present throughout the testes. The number of hub cells is not affected. Reduced DE-cadherin levels in the hub cells. Absence of integrin clustering and decreased focal adhesion kinase (FAK) phosphorylation at the hub/cyst stem cell interface.
messages: Nucleus
messages: Secreted
messages: The name 'shriveled' derives from the shrinking testes phenotype of mutants.

7227:Dmel CG18731
gene id: 7227:Dmel_CG18731
uniprot id: Q9VAI3
names: Similarity
messages: Belongs to the UPF0449 family.

7227:Dmel CG7466
gene id: 7227:Dmel_CG7466
uniprot id: Q9VLT6
uniprot id: X2J9V1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8928
gene id: 7227:Dmel_CG8928
uniprot id: Q9VXL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

7227:Dmel CG31872
gene id: 7227:Dmel_CG31872
uniprot id: Q9VKT1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG6575
gene id: 7227:Dmel_CG6575
uniprot id: Q9VD73
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed by a subset of glial cells found at the midline of the embryo stage 12 nervous system. Expression is highest during the formation of the embryonic axonal commissures, a process requiring midline glial cell function (at protein level).
messages: Flies exhibit disruption of the formation of commissural pathways and shows delays the completion of longitudinal pathfinding. The disruption in commissure formation is accompanied by reduced axon-glial contact, such that extending axons grow on other axons and form a tightly fasciculated bundle that arches over the midline.
messages: Has a role in intercellular carbohydrate-mediated cell adhesion.
messages: Membrane

7227:Dmel CG3956
gene id: 7227:Dmel_CG3956
uniprot id: P08044
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snail C2H2-type zinc-finger protein family.
messages: Essential for the correct specification of ventral-dorsal patterns.
messages: Nucleus

7227:Dmel CG42314
gene id: 7227:Dmel_CG42314
uniprot id: E6EK15
uniprot id: E6EK17
uniprot id: E6EK18
uniprot id: Q59DP8
uniprot id: Q59DP9
uniprot id: Q59DQ0
uniprot id: Q9V4C7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG7771
gene id: 7227:Dmel_CG7771
uniprot id: A0A0B4KFY1
uniprot id: A0A0B4KH05
uniprot id: P05709
names: Function
names: Miscellaneous
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Berkeley strain has 11 A-A-Q repeats.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Embryonic nerve cord.
messages: Mutations result in the loss of the precursor cells that give rise to midline cells of the embryonic central nervous system.
messages: Nucleus
messages: Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord. Required to correctly specify the formation of the central brain complex, which controls walking behavior. Also required for correct patterning of the embryonic genital disk and anal pad anlage. Plays a role in synapse development.

7227:Dmel CG6496
gene id: 7227:Dmel_CG6496
uniprot id: A0A1B2AL20
uniprot id: O96690
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the arthropod PDH family.
messages: Expressed at constant level, without strong circadian variations. Its amount nevertheless oscillates along day and night cycles in the termini of dorsally projected axons of LNvs.
messages: Increases total sleep time, decreases sleep latency, leads to loss of morning activity peak, and a failure to wake up in advance of light-on anticipation.
messages: Neuropeptide PDF is the main transmitter regulating circadian locomotor rhythms. Required to maintain behavioral rhythms under constant conditions by coordinating pacemaker interactions in the circadian system. Ectopic expression induces long periods, while its absence leads to short periods. Acts on small and large ventral lateral neurons to control sleep and regulates the state transition from sleep to wake (PubMed:19038223, PubMed:19230663).
messages: Predominantly expressed in adult head. Expressed at higher level in males than in females. In adult brain, it is specifically expressed in the ventral lateral neurons (LNvs) as well as in 2-4 tritocerebral cells and 4-6 abdominal cells.
messages: Secreted

7227:Dmel CG4502
gene id: 7227:Dmel_CG4502
uniprot id: Q9VM35
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.

7227:Dmel CG10422
gene id: 7227:Dmel_CG10422
uniprot id: P22745
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Flies exhibit abnormal cysts, they contain an excess number of cells that cannot differentiate into gametes.
messages: In cystoblasts and/or very early cystocytes in ovary and testis.
messages: Required to initiate both male and female gametogenesis. May regulate cystoblast cell divisions.

7227:Dmel CG16740
gene id: 7227:Dmel_CG16740
uniprot id: P08099
uniprot id: S5M1F0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Predominant opsin expressed in the dorsal ocelli.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7227:Dmel CG17715
gene id: 7227:Dmel_CG17715
uniprot id: M9NDV5
uniprot id: M9NFF0
uniprot id: Q5LJR2
uniprot id: Q8SYF7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG13849
gene id: 7227:Dmel_CG13849
uniprot id: Q95WY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

7227:Dmel CG5196
gene id: 7227:Dmel_CG5196
uniprot id: Q8SWX8
uniprot id: Q9VG80
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG10142
gene id: 7227:Dmel_CG10142
uniprot id: Q9W0Z1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG5033
gene id: 7227:Dmel_CG5033
uniprot id: Q7K0Y1
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Probable cloning artifact.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

7227:Dmel CG5692
gene id: 7227:Dmel_CG5692
uniprot id: Q9VB22
names: Similarity
messages: Belongs to the GPSM family.

7227:Dmel CG14777
gene id: 7227:Dmel_CG14777
uniprot id: Q9W588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG7770
gene id: 7227:Dmel_CG7770
uniprot id: M9PD09
uniprot id: Q9VW56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7227:Dmel CG1014
gene id: 7227:Dmel_CG1014
uniprot id: Q9W0F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

7227:Dmel CG5382
gene id: 7227:Dmel_CG5382
uniprot id: Q9VD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Membrane

7227:Dmel CG4042
gene id: 7227:Dmel_CG4042
uniprot id: Q9VPC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

7227:Dmel CG3678
gene id: 7227:Dmel_CG3678
uniprot id: Q9VEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

7227:Dmel CG10293
gene id: 7227:Dmel_CG10293
uniprot id: O01367
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By 20-hydroxyecdysone at the onset of metamorphosis.
messages: During embryogenesis, expression is seen in mesodermal precursors of somatic, visceral and pharyngeal muscle. Later in embryogenesis, expression is restricted to heart and muscle attachment sites of the epidermis. During onset of metamorphosis, expression is seen in muscle and muscle attachment cells.
messages: Expressed both maternally and zygotically during embryonic, larval and pupal development.
messages: Flies exhibit wing blisters and flight impairment.
messages: Nucleus
messages: Required for integrin-mediated cell-adhesion in wing blade. Vital role in steroid regulation of muscle development and to control heart rate. Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization.

7227:Dmel CG3708
gene id: 7227:Dmel_CG3708
uniprot id: Q7KW25
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7227:Dmel CG2146
gene id: 7227:Dmel_CG2146
uniprot id: A1Z6Z8
uniprot id: A1Z6Z9
uniprot id: A1Z700
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7227:Dmel CG32555
gene id: 7227:Dmel_CG32555
uniprot id: Q9VX32
names: Activity Regulation
names: Function
messages: GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.
messages: Negatively regulated by integrin, bsk and Src/Src64B.

7227:Dmel CG7917
gene id: 7227:Dmel_CG7917
uniprot id: A0A0B4KI24
uniprot id: Q27415
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoplasmin family.
messages: Binds to core histones and functions in the ATP-facilitated assembly of approximately regularly spaced nucleosomal arrays. May participate in parallel with other histone-binding proteins such as NAP-1.
messages: Decamer formed by two pentameric rings associated in a head-to-head fashion.
messages: Expressed both maternally and zygotically, present throughout development. Highest levels are found during oogenesis and in early embryos.
messages: Inactive for chromatin assembly. In vitro it appears to form a high molecular mass aggregate with the core histones.
messages: Nucleus

7227:Dmel CG7265
gene id: 7227:Dmel_CG7265
uniprot id: Q9VFE9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

7227:Dmel CG15534
gene id: 7227:Dmel_CG15534
uniprot id: Q9VA77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

7227:Dmel CG5553
gene id: 7227:Dmel_CG5553
uniprot id: I1WYG8
uniprot id: Q9VPH2
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Expressed at high levels in early embryos (particularly at the 0-4 h stage), then low throughout the larval and pupal stages and in adult males (PubMed:10366721). Shows elevated levels in adult females (PubMed:10366721).
messages: Expressed in embryos (at protein level).
messages: Heterodimer of a catalytic subunit Prim1 and a regulatory subunit Prim2, also known as the DNA primase complex (PubMed:6403945, PubMed:6409898). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit PolA1, the regulatory subunit PolA2, and the primase complex subunits Prim1 and Prim2 respectively (PubMed:6773966, PubMed:6403945, PubMed:6409898). PolA1 associates with the DNA primase complex before association with PolA2 (PubMed:6409898).
messages: Mutants exhibit eye defects and a delay in the S- phase of the cell cycle.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6773966, PubMed:6409898, PubMed:6403945). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:6812052). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:6812052). Stabilizes and modulates the activity of the catalytic subunit (By similarity).
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

7227:Dmel CG11982
gene id: 7227:Dmel_CG11982
uniprot id: Q9VHI7
names: Function
names: Miscellaneous
names: Subunit
messages: 'Iruka' means dolphin in Japanese. The name was chosen because dolphin preys on the Argonauta octopus, similar to Iruka 'preying' on the protein Argonaute.
messages: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:30503771). Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex (PubMed:30503771). By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing (PubMed:30503771).
messages: Interacts (via N-terminus) with CG7546 (via Ubl domain).

7227:Dmel CG6686
gene id: 7227:Dmel_CG6686
uniprot id: Q95TU2
uniprot id: Q9VKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

7227:Dmel CG9806
gene id: 7227:Dmel_CG9806
uniprot id: Q9W2S8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG18211
gene id: 7227:Dmel_CG18211
uniprot id: P35004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG10909
gene id: 7227:Dmel_CG10909
uniprot id: Q9VG21
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

7227:Dmel CG4804
gene id: 7227:Dmel_CG4804
uniprot id: Q9VL44
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG7933
gene id: 7227:Dmel_CG7933
uniprot id: P20348
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the janus family.
messages: JanA and janB regulate somatic sex differentiation.
messages: Somatic and germline cells. Isoform B is expressed in both sexes and in somatic and germ line cells. Isoform A is expressed in males and is germ line specific.
messages: The non-sex-specific transcript is present at all stages.
messages: Transcription of janA gives rise to two sex-specific and one non-sex-specific transcripts.

7227:Dmel CG6172
gene id: 7227:Dmel_CG6172
uniprot id: P22808
uniprot id: Q0KHX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-2 homeobox family.
messages: Expressed in the CNS and midgut.
messages: Nucleus
messages: Probable transcriptional regulator involved in the regulation of the proneural AS-C genes and the neurogenic genes of the enhancer of split complex. Could specifically activate proneural genes in the ventral-most neuroectoderm.

7227:Dmel CG7249
gene id: 7227:Dmel_CG7249
uniprot id: X2J9F6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7227:Dmel CG9249
gene id: 7227:Dmel_CG9249
uniprot id: E1JHN2
uniprot id: Q9VIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

7227:Dmel CG10069
gene id: 7227:Dmel_CG10069
uniprot id: Q8MLW5
uniprot id: Q9W2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

7227:Dmel CG3329
gene id: 7227:Dmel_CG3329
uniprot id: Q9VUJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG30118
gene id: 7227:Dmel_CG30118
uniprot id: Q7K556
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3-phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration.
messages: Isoform A: Expressed in the head. Isoform B: Expressed in the head.
messages: cytosol

7227:Dmel CG33694
gene id: 7227:Dmel_CG33694
uniprot id: Q9VKH9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG31662
gene id: 7227:Dmel_CG31662
uniprot id: P58951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily.
messages: Cell membrane
messages: Expressed in neurons of the terminal external chemosensory organ of larvae.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG10413
gene id: 7227:Dmel_CG10413
uniprot id: Q9VJ75
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3759
gene id: 7227:Dmel_CG3759
uniprot id: Q9VLC3
names: Similarity
messages: Belongs to the multicopper oxidase family.

7227:Dmel CG6498
gene id: 7227:Dmel_CG6498
uniprot id: Q9VUQ9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

7227:Dmel CG12376
gene id: 7227:Dmel_CG12376
uniprot id: A0A0B4LFU0
uniprot id: Q8SZV0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2260
gene id: 7227:Dmel_CG2260
uniprot id: Q9W3K3
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG4065
gene id: 7227:Dmel_CG4065
uniprot id: H5V8E9
uniprot id: Q9W1A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm
messages: Probable auxillary component of a complex displaying alpha (N-terminal) acetyltransferase activity.

7227:Dmel CG8182
gene id: 7227:Dmel_CG8182
uniprot id: A0A0B4LFI4
uniprot id: Q6WV20
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:12829714).
messages: Expressed both maternally and zygotically. Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development.
messages: Expressed in developing oocytes and egg chambers. No expression observed during embryonic stages 9-11. During embryonic stages 12-13, specific expression is observed in the developing tracheal branches and brain. During embryonic stages 14-17, expression is restricted to the dorsal longitudinal trachea. In third instar larvae imaginal wing disk, expressed in clusters of cells in the presumptive pleura and notum. In eye-antennal imaginal disk, shows a very distinct band of expression at the morphogenetic furrow and weaker expression in the presumptive eye posterior to the furrow, no expression is detected in the presumptive antennal or head region anterior to the furrow. No expression observed in leg or haltere imaginal disks.
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG1137
gene id: 7227:Dmel_CG1137
uniprot id: Q9VI32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

7227:Dmel CG8846
gene id: 7227:Dmel_CG8846
uniprot id: Q9XZ56
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the eIF4E-binding protein family.
messages: Expressed during all developmental stages.
messages: Hypophosphorylated Thor/4E-BP competes with eIF4G1 to interact with eIF4E1; insulin stimulated Akt1 or Tor phosphorylation of Thor/4E-BP causes dissociation of the complex allowing eIF4G1 to bind and consequent initiation of translation.
messages: Impaired innate immune response.
messages: Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, impairs its ability to prevent the interaction between eIF4G1 and eIF4E1, without affecting its interaction with free eIF4E1 (PubMed:14645523, PubMed:25702871). Phosphorylated in rtesponse to insulin (PubMed:11389445). Phosphorylation at Thr-46 is regulated by Tor and constitutes the major phosphorylation event that regulates activity (PubMed:14645523).
messages: Repressor of translation initiation that regulates eIF4E1 activity by preventing its assembly into the eIF4F complex (PubMed:11389445, PubMed:19804760, PubMed:25702871). Hypophosphorylated form competes with eIF4G1 and strongly binds to eIF4E1, leading to repress translation (PubMed:25702871). In contrast, hyperphosphorylated form dissociates from eIF4E1, allowing interaction between eIF4G1 and eIF4E1, leading to initiation of translation (PubMed:25702871). Acts as a regulator of various biological processes, such as innate immunity, cell growth or synaptic transmission (PubMed:10811906, PubMed:11389445, PubMed:27525480). Acts downstream of phosphoinositide-3-kinase (PI3K) to regulate cell growth (PubMed:11389445). Extends lifespan upon dietary restriction by regulating the mitochondrial translation (PubMed:19804760). Acts as a regulator of lifespan in response to cold by regulating the mitochondrial translation (PubMed:28827349). Acts as a negative regulator of presynaptic release of neurotransmitter in motor neurons: Thor expression is induced in response to insulin signaling, leading to prevent of translation of complexin (cpx), a protein known to regulate the exocytosis of synaptic vesicles (PubMed:27525480). Acts as a negative regulator of synaptic strength at the neuromuscular junction: Thor expression in response to acute fasting prevents translation, thereby suppressing retrograde synaptic enhancement (PubMed:27916456).
messages: The YXXXXLphi motif mediates interaction with eIF4E1 (PubMed:11389445). Compared to other members of the family this YXXXXLphi is atypical and interaction with eIF4E1 is weaker (PubMed:11389445).
messages: Up-regulated in response to bacterial infection (PubMed:10811906). Expression is induced by foxo: in neurons, foxo-dependent expression is activated in response to insulin signaling, while in muscle foxo-dependent expression is activated in response to fasting (PubMed:27525480, PubMed:27916456).
messages: Widely expressed.

7227:Dmel CG4965
gene id: 7227:Dmel_CG4965
uniprot id: M9PBC2
uniprot id: Q03019
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the MPI phosphatase family.
messages: Expressed in developing male and female germ cells.
messages: Required during meiosis. Regulates the transition from the extended G2 phase to the onset of the first meiotic division.

7227:Dmel CG11709
gene id: 7227:Dmel_CG11709
uniprot id: Q9VYX7
uniprot id: X2JEI8
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although suggested, the interaction with GNBP1 has not been experimentally demonstrated.
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: In larvae, it is expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.
messages: Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).
messages: Secreted
messages: Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.

7227:Dmel CG5788
gene id: 7227:Dmel_CG5788
uniprot id: Q7K738
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.
messages: Interacts with the E3 ubiquitin ligase ari-1 (via RING-type 1 zinc finger).
messages: Nuclei in larval muscles (myonuclear), are mislocalized and often clustered, likely due to mislocalization of the LINC complex, demonstrated by the aberrant localization of the complex member Msp300.
messages: Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin (PubMed:27702987, PubMed:29689197, PubMed:21900267). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins (PubMed:29689197, PubMed:27702987, PubMed:21900267). Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197). Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197). Likely to function with ari-1 to control metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and it's heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267). Able to function with LUBEL to mediate 'Lys-63'- and linear 'Met-1'-linked polyubiquitin involved in the heat stress response (PubMed:27702987).

7227:Dmel CG6342
gene id: 7227:Dmel_CG6342
uniprot id: Q9VGZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

7227:Dmel CG4572
gene id: 7227:Dmel_CG4572
uniprot id: Q9VDT5
names: Similarity
messages: Belongs to the peptidase S10 family.

7227:Dmel CG3773
gene id: 7227:Dmel_CG3773
uniprot id: Q9VDY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

7227:Dmel CG1869
gene id: 7227:Dmel_CG1869
uniprot id: Q9VZV2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG31743
gene id: 7227:Dmel_CG31743
uniprot id: Q9VJG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane

7227:Dmel CG7176
gene id: 7227:Dmel_CG7176
uniprot id: B7Z0E0
uniprot id: Q7KUB0
uniprot id: Q7KUB1
uniprot id: Q8IQA7
uniprot id: Q9VSI6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

7227:Dmel CG4200
gene id: 7227:Dmel_CG4200
uniprot id: Q9VXH3
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

7227:Dmel CG31522
gene id: 7227:Dmel_CG31522
uniprot id: A0A0B4KF65
uniprot id: Q8IPL8
uniprot id: Q9VN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG1616
gene id: 7227:Dmel_CG1616
uniprot id: A0A0B4LEV2
uniprot id: Q26454
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Essential role in mitotic DNA replication but not in endoreplication.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable).
messages: Nucleus

7227:Dmel CG33282
gene id: 7227:Dmel_CG33282
uniprot id: Q9VQP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG4821
gene id: 7227:Dmel_CG4821
uniprot id: E1JI93
uniprot id: Q8IQB8
uniprot id: Q9VSU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11356
gene id: 7227:Dmel_CG11356
uniprot id: Q9VYP6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7227:Dmel CG8520
gene id: 7227:Dmel_CG8520
uniprot id: Q7K4T8
names: Similarity
messages: Belongs to the AFG1 ATPase family.

7227:Dmel CG1518
gene id: 7227:Dmel_CG1518
uniprot id: Q9VRE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

7227:Dmel CG45017
gene id: 7227:Dmel_CG45017
uniprot id: Q7KV26
uniprot id: Q9VYE6
uniprot id: Q9VYE7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7227:Dmel CG8309
gene id: 7227:Dmel_CG8309
uniprot id: A0A0B4LFB3
uniprot id: Q7JVI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm
messages: Golgi apparatus

7227:Dmel CG6847
gene id: 7227:Dmel_CG6847
uniprot id: Q9VX01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG7246
gene id: 7227:Dmel_CG7246
uniprot id: Q9W397
names: Similarity
messages: Belongs to the UTP6 family.

7227:Dmel CG5529
gene id: 7227:Dmel_CG5529
uniprot id: Q24255
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: B-H1 and B-H2 are abundant in the eye-antenna imaginal disk. Expressed in R1 and R6 cells throughout larval stage until 30 hours after puparium formation, at which time expression is seen in the anterior and posterior primary pigment cells. Coexpressed in embryonic glial cells, neurons of the CNS and PNS, most latitudinal anterior cells of the developing notum and the central circular region of the leg and antennal imaginal disk throughout larval development.
messages: B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
messages: Belongs to the Antp homeobox family.
messages: Coexpressed at high levels with B-H1 in embryo and pupae and at low levels in larvae.
messages: Nucleus

7227:Dmel CG6767
gene id: 7227:Dmel_CG6767
uniprot id: M9PEP5
uniprot id: M9PEY1
uniprot id: M9PF46
uniprot id: M9PHW7
uniprot id: Q9VT32
uniprot id: Q9VT33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

7227:Dmel CG31874
gene id: 7227:Dmel_CG31874
uniprot id: Q8IPD2
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

7227:Dmel CG12443
gene id: 7227:Dmel_CG12443
uniprot id: A0A0B4K7X1
uniprot id: Q6Q7I9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7227:Dmel CG15095
gene id: 7227:Dmel_CG15095
uniprot id: Q8MRP7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3707
gene id: 7227:Dmel_CG3707
uniprot id: A0A0F6QB50
uniprot id: Q9W517
uniprot id: X2JAA8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the WAPL family.
messages: Expressed in embryos.
messages: Flies exhibit brain cell metaphases where sister chromatids of all chromosomes are aligned parallel to each other instead of assuming the typical morphology, heterochromatin condensation or chromosome segregation are not affected.
messages: Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation.

7227:Dmel CG31133
gene id: 7227:Dmel_CG31133
uniprot id: Q95T19
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP.
messages: Expressed from late embryogenesis with expression continuing in larva, pupa and adult (at protein level).
messages: Mitochondrion

7227:Dmel CG5182
gene id: 7227:Dmel_CG5182
uniprot id: Q9VK37
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

7227:Dmel CG7727
gene id: 7227:Dmel_CG7727
uniprot id: M9NDH5
uniprot id: M9NE22
uniprot id: M9NEM2
uniprot id: M9NFQ0
uniprot id: M9NGF6
uniprot id: P14599
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the APP family.
messages: During development, plays a role in the regulation of the neddylation pathway. Appl and APP-BP1 interact antagonistically during development.
messages: Expressed in all developmental stages.
messages: Expressed in postmitotic neurons in the central and peripheral nervous systems. Within the nervous system, transcripts are not observed in neuroblasts, newly generated neurons and at least one class of presumed glial cells.
messages: Interacts (via the intracellular domain, ICD) with APP-BP1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Overexpression inhibits the Nedd8 conjugation pathway, disrupts the normal bristle pattern in the fly thorax, and induces apoptosis in wing imaginal disks.
messages: The NPTY motif mediates the interaction with clathrin (By similarity). The clathrin-binding site is essential for its association with X11-alpha, -beta, and -gamma. The sequence specific recognition extends to peptide residues that are C-terminal to the NPXY motif. This interaction appears to be independent of phosphorylation (By similarity).
messages: Was originally (PubMed:2494667) thought to be vnd but further analysis (PubMed:2127912) has clearly shown that it corresponds to Appl.

7227:Dmel CG3631
gene id: 7227:Dmel_CG3631
uniprot id: Q95T10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM20 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans.

7227:Dmel CG14426
gene id: 7227:Dmel_CG14426
uniprot id: P32845
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to-cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
messages: Appears first at nuclear cell cycle 11 and disappears rapidly as cellularization begins. During cycle 14, nullo protein levels are coupled to the nucleocytoplasmic ratio.
messages: Blastoderm. Throughout the entire cortex of the embryo although the distribution is not uniform.

7227:Dmel CG11194
gene id: 7227:Dmel_CG11194
uniprot id: Q7KM13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEY family.
messages: Nucleus
messages: Transcriptional repressor which acts as a downstream effector of Notch signaling.

7227:Dmel CG1386
gene id: 7227:Dmel_CG1386
uniprot id: Q9VZ19
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG1946
gene id: 7227:Dmel_CG1946
uniprot id: A1Z739
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3501
gene id: 7227:Dmel_CG3501
uniprot id: Q9W1Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC8/EMC9 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins.

7227:Dmel CG12970
gene id: 7227:Dmel_CG12970
uniprot id: A1ZA55
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the mab-21 family.
messages: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in antiviral innate immunity (PubMed:34261127, PubMed:34261128). Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (PubMed:34261127). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127, PubMed:34261128). 3',2'-cGAMP is protected from poxin cleavage (PubMed:34261127).
messages: The enzyme activity is specifically activated by double-stranded RNA (dsRNA) (PubMed:34261127, PubMed:34261128). Recognizes long dsRNA (>30 bp) with no preference for 5' RNA phosphorylation (PubMed:34261127).

7227:Dmel CG42282
gene id: 7227:Dmel_CG42282
uniprot id: D0IQL4
uniprot id: Q8IP58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11228
gene id: 7227:Dmel_CG11228
uniprot id: A0A0B4KFW0
uniprot id: Q8T0S6
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed in CNS during embryogenesis. In third instar larvae, it is expressed throughout all imaginal disks.
messages: Homodimer. Interacts with Sav and Wts. Interacts (via SARAH domain) with Ex. Interacts with Kibra.
messages: Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Phosphorylates Sav, Wts and Th/DIAP1. Regulates the level of Th/DIAP1 apoptosis inhibitor.
messages: Transcriptionally regulated by Gcm (Glial cells missing).

7227:Dmel CG5491
gene id: 7227:Dmel_CG5491
uniprot id: Q9VBB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS1 and IntS9 (PubMed:23288851). Interaction with IntS1 is likely to be important for promoting 3'-end processing of snRNAs (PubMed:23288851).
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424, PubMed:23288851). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS1 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
messages: Nucleus
messages: The PHD-type zinc finger is not required for 3'-end snRNA processing.

7227:Dmel CG5404
gene id: 7227:Dmel_CG5404
uniprot id: Q9VF45
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG12630
gene id: 7227:Dmel_CG12630
uniprot id: M9PDE2
uniprot id: Q9U3V5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Expression in the Malpighian tubules (MTs) and stomatogastric nervous system starts at embryonic stage 10. At stage 11, expression in the head domain is initiated in the clypeolabrum in two bilaterally symmetric clusters of cells. At stage 12, expression appears in the central nervous system (CNS) of the trunk and the epidermis. The staining in the hindgut is maintained throughout embryogenesis. At stage 13, expression is present in elongating MTs. The anterior staining is detected in cells that invaginate into the stomodeum and by stage 15 onwards, in cells close to the pharynx. Also expressed in cells of the brain, the second constriction of the gut, the trunk epidermis, the anterior segments of the CNS (the three thoracic and the first two abdominal segments) and in the MTs. From stage 12 onwards, tsh and tio are colocalized in some cells.
messages: Nucleus
messages: The tsh tio gene pair seems to have arisen from a recent duplication event: tsh has the dominant role compared to tio.
messages: Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg.

7227:Dmel CG8063
gene id: 7227:Dmel_CG8063
uniprot id: Q9VG08
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major royal jelly protein family.
messages: Expressed at all stages with highest levels in late-stage pupae and adults.
messages: Secreted
messages: Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages.

7227:Dmel CG32435
gene id: 7227:Dmel_CG32435
uniprot id: Q9NBD7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CLASP family.
messages: Cleavage furrow
messages: Expressed in testis and ovary.
messages: Expressed throughout development, although expression is low in pupae. At late developmental stages expression becomes pronounced in muscles and the nervous system, particularly within the intersegmental nerve b (ISNb).
messages: Interacts with CLIP-190 and microtubules.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microtubules that probe the peripheral growth cone domain, where guidance signals exert their influence on cytoskeletal organization. Also required during oogenesis for the organization of the polarized microtubule network inside the 16-cell cyst that ensures oocyte differentiation.
messages: Nucleus
messages: centrosome
messages: cytoskeleton
messages: growth cone
messages: spindle

7227:Dmel CG9754
gene id: 7227:Dmel_CG9754
uniprot id: Q9W2H9
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064).
messages: Expressed in female gonads (at protein level).
messages: In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). Interacts (via NIR region) with nxf2 (via TAP-C domain); the interaction is direct (PubMed:31368590, PubMed:31219034, PubMed:31570835, PubMed:31384064).
messages: Mutants are viable but show oogenesis defects (PubMed:26494711). They also display up-regulation of transposable elements with loss of transposon H3K9 methylation and sterility in female flies (PubMed:26472911, PubMed:26494711). No effect on the abundance or content of piRNA populations or on the nuclear localization of piwi (PubMed:26472911, PubMed:26494711). RNAi-mediated knockdown in the germline increases transposon expression and impairs nuclear localization of nxf2 in nurse cells by reducing its stability (PubMed:31570835, PubMed:31219034).
messages: N-terminal region is necessary and sufficient to enforce silencing of an artificial reporter gene.
messages: Nucleus
messages: The name 'panoramix' derives from the mentor who empowers the French comic book character Asterix to perform his feats of strength.

7227:Dmel CG6897
gene id: 7227:Dmel_CG6897
uniprot id: Q9VVR2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BORA family.
messages: Cytoplasm
messages: Interacts with aur.
messages: Nucleus
messages: Phosphorylated by aur.
messages: Required for the activation of Aurora-A (aur) at the onset of mitosis.

7227:Dmel CG2507
gene id: 7227:Dmel_CG2507
uniprot id: Q04164
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Expressed in most, if not all, ectodermal tissues which produce a cuticle.
messages: The extracellular domain is sufficent for conferring apical characteristics on the salivary gland membrane.
messages: Throughout development.
messages: Vital for larval development (PubMed:1339334). During salivary tube elongation, possibly modulates cellular adhesion between the apical surface and apical extracellular matrix, and acts as an apical membrane determinant that functions in apical membrane expansion independently of crb and Cad99C (PubMed:24718992).

7227:Dmel CG7433
gene id: 7227:Dmel_CG7433
uniprot id: Q9VW68
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

7227:Dmel CG8596
gene id: 7227:Dmel_CG8596
uniprot id: Q9VS51
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2292
gene id: 7227:Dmel_CG2292
uniprot id: A1Z838
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

7227:Dmel CG32704
gene id: 7227:Dmel_CG32704
uniprot id: Q9W365
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG40300
gene id: 7227:Dmel_CG40300
uniprot id: Q7PLK0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at the 5' end. In testis, however, associates with Su(Ste) and AT-chX-1 piRNAs mostly produced from antisense precursors. Shows RNA cleavage activity. In the germline, acts to amplify pools of antisense piRNAs, among others Su(Ste), AT-chX-1 and roo, and to limit sense piRNA accumulation. Forms a complex with smg, twin, aub and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis. Involved in transposon silencing in the adult brain.
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
messages: Cytoplasm
messages: Expressed maternally. Expression is high in early embryos but gradually decreases as development proceeds (at protein level).
messages: Female sterility. Male semi-sterility accompanied by production of Ste protein crystals in primary spermatocytes. Mutant males fail to maintain germline stem cells.
messages: Has been given the gene name AGO3 by FlyBase based on the literature but is more similar to members of the Piwi subfamily.
messages: In ovary, expressed in germline stem cells, germline cyst cells, nurse cells and oocytes during early stages. Also found in the somatic cap cells of the germarium. In testis, expressed in germline stem cells, primary gonial cells and early spermatocytes. No expression detected in the somatic hub cells at the apical tip of the testis (at protein level). Expressed in neurons throughout the adult brain and in the mushroom body subdivision in the peduncle. In the mushroom body, expressed only in gamma and core alpha-beta neurons.
messages: Interacts with aub (PubMed:19959991). Interacts (when methylated on arginine residues) with tud (PubMed:19959991). Forms a complex with smg, twin, aub, nos mRNA and piRNAs that target the nos 3'-untranslated region, in early embryos (PubMed:20953170). Interacts (via the N-terminal region when symmetrically methylated on arginine residues) with papi (via C-terminus); this interaction is RNA-independent and may be required for AGO3 localization to the nuage (PubMed:21447556). Interacts with TER94 and tral (PubMed:21447556).
messages: Symmetrically dimethylated on Arg-4, Arg-68 and Arg-70, most likely by csul.

7227:Dmel CG32026
gene id: 7227:Dmel_CG32026
uniprot id: Q8T0R3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

7227:Dmel CG7497
gene id: 7227:Dmel_CG7497
uniprot id: Q9VVJ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG13916
gene id: 7227:Dmel_CG13916
uniprot id: Q9W0F4
names: Similarity
messages: Belongs to the SCC3 family.

7227:Dmel CG34448
gene id: 7227:Dmel_CG34448
uniprot id: A8DYT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG14517
gene id: 7227:Dmel_CG14517
uniprot id: Q9VAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the transfer of galactose onto proteins or lipids.
messages: Membrane

7227:Dmel CG1385
gene id: 7227:Dmel_CG1385
uniprot id: A0A1B2AIZ7
uniprot id: P36192
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the invertebrate defensin family. Type 1 subfamily.
messages: By bacterial infection (at protein level).
messages: Hemolymph (at protein level).
messages: Responsible for the anti Gram-positive activity of immune hemolymph. Expressed in the absence of immune challenge during metamorphosis.
messages: Secreted

7227:Dmel CG34366
gene id: 7227:Dmel_CG34366
uniprot id: A8DYR5
uniprot id: R9PY39
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2079
gene id: 7227:Dmel_CG2079
uniprot id: Q9W3R6
names: Subunit
messages: Bindings to phosphatidylinositol 3-kinase and SHP2.

7227:Dmel CG7948
gene id: 7227:Dmel_CG7948
uniprot id: C6SV45
uniprot id: Q27297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA (By similarity).
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
messages: Highly expressed in ovaries.
messages: Nucleus
messages: Spindle genes are required for each of the symmetry-breaking steps that generate polarity during egg axis formation; oocyte positioning at the posterior of the cyst to generate the first AP polarity and inhibition of gurken (grk) signaling to the follicle cell layer to polarize first the AP axis and then DV axis. May have a role in female meiosis.

7227:Dmel CG12153
gene id: 7227:Dmel_CG12153
uniprot id: O17468
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Expressed maternally and zygotically throughout development to adults (male and female).
messages: Nucleus
messages: Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4.
messages: Was originally thought to be involved in protamine removal but this was shown to be incorrect in the subsequent published erratum.

7227:Dmel CG6323
gene id: 7227:Dmel_CG6323
uniprot id: Q8IMQ7
uniprot id: Q9VB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG10723
gene id: 7227:Dmel_CG10723
uniprot id: Q9V3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

7227:Dmel CG6302
gene id: 7227:Dmel_CG6302
uniprot id: M9PF40
uniprot id: Q9VTE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7227:Dmel CG11922
gene id: 7227:Dmel_CG11922
uniprot id: P32029
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in early embryogenesis in 14 symmetrical pairs of segmentally arranged neuroblasts and in developing peripheral nervous system. Also, later in embryogenesis, in a cluster of cells in head region.
messages: Expressed in embryos (maximal level between 5-12 hours) and at a low level in larvae.
messages: Involved in development during embryogenesis.
messages: Nucleus

7227:Dmel CG31460
gene id: 7227:Dmel_CG31460
uniprot id: A0A0B4LGZ4
uniprot id: Q8INQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRTCAP2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7227:Dmel CG2488
gene id: 7227:Dmel_CG2488
uniprot id: Q0E8P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA photolyase class-1 family.
messages: perinuclear region

7227:Dmel CG3662
gene id: 7227:Dmel_CG3662
uniprot id: Q2PDW1
uniprot id: Q9VPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

7227:Dmel CG9717
gene id: 7227:Dmel_CG9717
uniprot id: Q9I7H4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10260
gene id: 7227:Dmel_CG10260
uniprot id: M9PDM4
uniprot id: Q9W4X4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7227:Dmel CG16961
gene id: 7227:Dmel_CG16961
uniprot id: P81915
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 15 cells in the antenna but not the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentyl acetate and pyrazines.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG1628
gene id: 7227:Dmel_CG1628
uniprot id: Q7KVQ8
uniprot id: Q9W2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG5984
gene id: 7227:Dmel_CG5984
uniprot id: Q9VB59
names: Similarity
messages: Belongs to the filamin family.

7227:Dmel CG3183
gene id: 7227:Dmel_CG3183
uniprot id: Q7JX41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

7227:Dmel CG5718
gene id: 7227:Dmel_CG5718
uniprot id: Q8SX97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

7227:Dmel CG3597
gene id: 7227:Dmel_CG3597
uniprot id: M9PE54
uniprot id: Q9VQB3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

7227:Dmel CG43327
gene id: 7227:Dmel_CG43327
uniprot id: A0A0B4K829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG16747
gene id: 7227:Dmel_CG16747
uniprot id: A1Z8U1
uniprot id: A1Z8U2
uniprot id: P54361
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Expressed in all stages of embryonic and larval development as well as in pupae and adults.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (By similarity). Required for cellular differentiation in neuronal and myogenic lineages during embryonic development (PubMed:8878684).

7227:Dmel CG3227
gene id: 7227:Dmel_CG3227
uniprot id: Q8SYK5
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495, PubMed:23468431). Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development (PubMed:21765394, PubMed:25561495).
messages: Homodimer. Interacts (via BEN domain) with Su(H). Interacts with Cp190.
messages: Initially expressed ubiquitously in the early embryo and later throughout the developing ectoderm but becomes highly restricted to the developing CNS and PNS. Peak expression seen at the blastoderm stage (2-4 hours) (at protein level).
messages: Nucleus
messages: The BEN domain mediates DNA-binding.

7227:Dmel CG3983
gene id: 7227:Dmel_CG3983
uniprot id: Q8MT06
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family.
messages: Impaired embryonic development resulting in a profoundly reduced rate of larval hatching.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: May play a role in regulating cellular proliferation.
messages: nucleolus

7227:Dmel CG12775
gene id: 7227:Dmel_CG12775
uniprot id: Q9V9M7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

7227:Dmel CG8138
gene id: 7227:Dmel_CG8138
uniprot id: Q9VFY6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

7227:Dmel CG15715
gene id: 7227:Dmel_CG15715
uniprot id: Q9VUU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG3756
gene id: 7227:Dmel_CG3756
uniprot id: Q9VMX3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

7227:Dmel CG11449
gene id: 7227:Dmel_CG11449
uniprot id: Q9VNU3
names: Similarity
messages: Belongs to the CFAP45 family.

7227:Dmel CG6025
gene id: 7227:Dmel_CG6025
uniprot id: P25160
names: Function
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

7227:Dmel CG31362
gene id: 7227:Dmel_CG31362
uniprot id: C0HKF7
uniprot id: C0HKF8
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Abundantly expressed in the larval gut.
messages: Belongs to the peptidase S1 family.
messages: Expression appears at the late embryo stage and continues to increase in abundance throughout the larval stage. No expression in pupae but is expressed in the adult.
messages: Major function may be to aid in digestion.

7227:Dmel CG7546
gene id: 7227:Dmel_CG7546
uniprot id: B7Z0D3
uniprot id: B7Z0D4
uniprot id: M9ND57
uniprot id: M9PBU3
uniprot id: M9PEE7
uniprot id: M9PHN9
uniprot id: Q9VS82
uniprot id: Q9VS83
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

7227:Dmel CG10724
gene id: 7227:Dmel_CG10724
uniprot id: Q9VU68
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat AIP1 family.
messages: Expressed in pupal wing cells.
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:17565945). Together with GMF, promotes Arp2/3-nucleated actin filament array disassembly (PubMed:25308079). Essential for organismal and cell viability (PubMed:17565945). Required for the development of normal wing cell planar polarity (PubMed:17565945). In egg chambers and together with GMF, plays an important role in directional migration of border cell clusters (PubMed:25308079).
messages: Pupals exhibit grossly abnormal epidermal hairs on wings, an abnormal accumulation of F-actin and microtubules, and disruption of the frizzled-based planar cell polarity system (PubMed:17565945). RNAi-mediated knockdown results in F-actin accumulation and moderate border cell migration delays in stage 10 egg chambers (PubMed:25308079). RNAi-mediated knockdown in border cells results in accumulation of F-actin dots, enriched with Arpc1 and GMF (PubMed:25308079). Simultaneous RNAi-mediated knockdown of GMF and flr results in an accumulation of F-actin in follicular epithelium of developing egg chambers, and in deformation of bristles in the thorax (PubMed:25308079). Simultaneous RNAi-mediated knockdown in border cells of GMF and flr enhances the accumulation of F-actin foci (PubMed:25308079).
messages: cytoskeleton

7227:Dmel CG33208
gene id: 7227:Dmel_CG33208
uniprot id: A0A0B4K6D5
uniprot id: A0A0B4K6N6
uniprot id: A0A0B4K703
uniprot id: A0A126GUS4
uniprot id: A0A126GUS6
uniprot id: Q86BA1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Defects in motor neuron guidance, myofilament organization and bristle formation. Surviving adult flies show abnormally shaped bristle cell processes that are variously straight, thick, bent, twisted and/or had abnormal 'club-like' or blunt tips.
messages: Directly regulated by Sox14 during pruning.
messages: During early development (stages 7-8), expressed in the ventral neurogenic region and in many nonneuronal tissues (including developing mesoderm, cells surrounding the cephalic furrow and amnioproctodeal invagination, and in gut primordia). This nonneuronal expression is also seen later in embryonic development (stages 11-17), where it is expressed within the anterior and posterior midgut primordia, the visceral musculature, and weakly in somatic musculature. During axonal pathfinding (stage 13 onward), expressed within the developing brain and ventral nerve cord in most, if not all, CNS neurons. Not highly expressed in peripheral sensory neurons.
messages: Interacts with plexA.
messages: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin.
messages: Present in neuronal cell bodies, along axons, and in growth cones. Appears in the nervous system at stage 13 and labels motor and CNS projections, and at later embryonic stages, it is present on axons that make up all motor axon pathways: the intersegmental nerve (ISN), the intersegmental nerves b and d (ISNb and ISNd), and the segmental nerves a and c (SNa and SNc). Also present in segment boundaries at the position of muscle attachment sites and at low levels in the lateral cluster of chordotonal organs (at protein level). Localizes to growing bristle tips in close proximity to the bristle cell membrane and at sites of bristle branching and actin localization. Localizes to growth cones.
messages: The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H(2)O(2) (EC 1.6.3.1) and that it is the produced H(2)O(2) that is responsible for the methionine-(R)-S-oxide production.

7227:Dmel CG3792
gene id: 7227:Dmel_CG3792
uniprot id: Q9VMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

7227:Dmel CG15444
gene id: 7227:Dmel_CG15444
uniprot id: C8VV47
uniprot id: E1JHT2
uniprot id: Q9VR07
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Expressed both maternally and zygotically. Developing embryos exhibit expression in the posterior hindgut, foregut, midgut, Malpighian tubules, anal plate, Garland cells, and a subset of cells in the central nervous system. Central nervous system expression is seen in segmentally repeating in cells flanking the midline of the ventral ganglion. Isoform A and isoform B are colocalized in both the nervous system and the fluid reabsorption system.
messages: Flies lacking this protein, in a wild-type background, display no observable behavioral defects. In a Shaker mutant background, flies lacking ine exhibit downturned wings and an indented thorax. Flies lacking ine exhibit increased excitability of the larval peripheral nerve by causing the defective re-uptake of the substrate neurotransmitter of the ine transporter and thus overstimulation by this neurotransmitter. Flies lacking ine increase the growth of the perineurial glial layer of the larval peripheral nerve. Flies overexpressing ine exhibit delayed onset of long-term facilitation and increased failure rate of transmitter release at the larval neuromuscular junction, reduced amplitude of larval nerve compound action potentials, suppression of the leg-shaking behavior of mutants defective in the Shaker-encoded potassium channel, and temperature-sensitive paralysis.
messages: Membrane
messages: Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osmolyte transport within the Malpighian tubule and hindgut.
messages: The long N terminus is uncommon among members of the sodium- and chloride-dependent neurotransmitter transporter family but is required for efficient transporter activity.

7227:Dmel CG15440
gene id: 7227:Dmel_CG15440
uniprot id: Q8SXG7
names: Similarity
messages: Belongs to the RRM TRSPAP family.

7227:Dmel CG10616
gene id: 7227:Dmel_CG10616
uniprot id: C8VV60
uniprot id: M9NE87
uniprot id: Q9VTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.
messages: Membrane

7227:Dmel CG10748
gene id: 7227:Dmel_CG10748
uniprot id: Q9VU28
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

7227:Dmel CG8771
gene id: 7227:Dmel_CG8771
uniprot id: A0A0B4K859
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nup188 family.
messages: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus.
messages: Lethal at the pupal stage with stronger phenotype with temperature increase (PubMed:32275884). Impairs sensory dendrite tiling on the larval body (PubMed:32275884). In escapers flies, leads to decreased negative geotaxis and seizures (PubMed:32275884).
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

7227:Dmel CG4825
gene id: 7227:Dmel_CG4825
uniprot id: Q9VPD3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Lethal at the first instar larval stage (PubMed:31869331). RNAi-mediated knockdown in salivary glands reduces phosphatidylserine (PS) levels and depletes Akt1 from the plasma membrane contributing to cell growth defects probably by affecting the insulin pathway; causes a shift from phospholipid synthesis to neutral lipid synthesis, which results in ectopic lipid accumulation in third instar larval salivary glands; reduces mitochondrial PS levels thereby impairing mitochondrial protein import and mitochondrial integrity (PubMed:31869331).

7227:Dmel CG5501
gene id: 7227:Dmel_CG5501
uniprot id: Q4AB24
uniprot id: Q4AB27
uniprot id: Q8T6L6
uniprot id: Q8T6L7
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7939
gene id: 7227:Dmel_CG7939
uniprot id: A0A1B3Q3R0
uniprot id: P04359
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

7227:Dmel CG6530
gene id: 7227:Dmel_CG6530
uniprot id: A0A0B4LFS2
uniprot id: Q9V818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG42595
gene id: 7227:Dmel_CG42595
uniprot id: A0A0B7P9G0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Interacts with PRL-1, possibly at the plasma membrane.
messages: Probable metal transporter (By similarity). Acts downstream of PRL-1 and protects the nervous system against olfactory carbon dioxide stimulation (PubMed:31404830).
messages: RNAi-mediated knockdown in the nervous system results in a held-up wing phenotype after eclosion and upon carbon dioxide stimulation.

7227:Dmel CG11416
gene id: 7227:Dmel_CG11416
uniprot id: Q9W148
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase II subunit 5-mediating protein family.
messages: Chromosome
messages: Cytoplasm
messages: Embryos hatch normally but first instar larvae show very little locomotion or feeding and die soon after hatching. Embryos show transcriptional defects with reduced expression of ebony and Ass. Somatically-rescued mutant larvae show defective germ line cell viability and differentiation with damaged DNA.
messages: Inhibits the activity of serine/threonine-protein phosphatases flw/PP1beta9C and Pp1-87B. Required for germ line cell viability and differentiation, normal transcriptional activity and maintenance of DNA integrity.
messages: Interacts with serine/threonine-protein phosphatases flw/PP1beta9C and Pp1-87B with higher affinity for Pp1-87B.
messages: Most abundant in early embryo, pupa and adult gonads (at protein level). In testis, expressed in mitotically proliferating spermatogonia and early primary spermatocytes with levels decreasing as spermatocytes mature and no expression in postmitotic stages.
messages: Nucleus

7227:Dmel CG7999
gene id: 7227:Dmel_CG7999
uniprot id: Q9VSF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 24 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Nucleus

7227:Dmel CG1871
gene id: 7227:Dmel_CG1871
uniprot id: M9PJE8
uniprot id: Q24337
names: Developmental Stage
names: Function
names: PTM
names: Similarity
messages: Acts as an enhancer of the rudimentary gene. Has a role in pyrimidine biosynthesis and the cell cycle.
messages: Belongs to the E(R) family.
messages: Expressed both maternally and zygotically. Zygotic expression is also seen in adult males.
messages: Phosphorylated in vitro by casein kinase II (CK2).

7227:Dmel CG33178
gene id: 7227:Dmel_CG33178
uniprot id: Q8SY97
uniprot id: X2JF29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

7227:Dmel CG10594
gene id: 7227:Dmel_CG10594
uniprot id: H8F4V5
uniprot id: Q9VRM7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Member of the Halloween gene group.
messages: Microsome membrane
messages: Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.

7227:Dmel CG6134
gene id: 7227:Dmel_CG6134
uniprot id: P48607
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: 'Spaetzle' means 'noodles' in German.
messages: During embryonic development, easter cleaves the signal peptide and also generates the C-terminal 12 kDa active fragment, C-106 (except for isoform 8.24 and isoform 11.27 as they do not contain the cleavage site) (PubMed:9533958). During the immune response, cleaved in the same manner by SPE (PubMed:16399077).
messages: Expressed both maternally and zygotically. All isoforms, except isoform 8.20, are rapidly degraded on cellularisation of the blastoderm embryo.
messages: Extracellular forms of isoform 8.19 and isoform 11.7 are glycosylated.
messages: Homodimer; disulfide-linked (PubMed:12872120, PubMed:9533958). In the presence of Tl, crystal structures show one Tl molecule bound to a spaetzle C-106 homodimer (PubMed:24733933, PubMed:24282309). However, the active complex probably consists of two Tl molecules bound to a spaetzle C-106 homodimer (PubMed:24282309, PubMed:24733933). This is supported by in vitro experiments which also show binding of the spaetzle C-106 dimer to 2 Tl receptors (PubMed:12872120). Ligand binding induces conformational changes in the extracellular domain of Tl (PubMed:24282309). This may enable a secondary homodimerization interface at the C-terminus of the Tl extracellular domain (PubMed:24282309).
messages: Secreted
messages: The activated form, spaetzle C-106, acts as a ligand for the Toll receptor (PubMed:12872120). Binding to Toll activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:8808632). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:8124709, PubMed:11212919).

7227:Dmel CG3139
gene id: 7227:Dmel_CG3139
uniprot id: P21521
uniprot id: X2J4C1
uniprot id: X2J979
names: Cofactor
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Homodimer or homotrimer (Potential). Identified in a complex with Syn and nwk (PubMed:29568072). Interacts with StnA and StnB via its second C2 domain. This interaction may mediate its retrieval from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.
messages: Intron retention.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: Partially edited.
messages: Synapse
messages: synaptic vesicle membrane

7227:Dmel CG1081
gene id: 7227:Dmel_CG1081
uniprot id: H1ZYG4
uniprot id: Q9VND8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rheb family.
messages: Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis (PubMed:22493059). Stimulates the phosphorylation of S6K through activation of TORC1 signaling (PubMed:22493059). May also have a role in activating TORC2 signaling (PubMed:22493059).
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: cytosol

7227:Dmel CG31477
gene id: 7227:Dmel_CG31477
uniprot id: Q9VH24
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

7227:Dmel CG4735
gene id: 7227:Dmel_CG4735
uniprot id: Q9W1I9
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity.
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations.
messages: Cytoplasm
messages: Interacts with Hsp83.
messages: Recessive female sterility with no effects on zygotic viability. Some strong alleles (WQ41 and WM40) also lead to male sterility.
messages: Strongly expressed in the germline stem cells and in 16-cell cysts. Present in the germ cells throughout embryogenesis. Defects are due to derepression of transposable elements and impaired piRNA biogenesis.

7227:Dmel CG5222
gene id: 7227:Dmel_CG5222
uniprot id: Q95TS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS1 and IntS12 (PubMed:23288851).
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
messages: Nucleus

7227:Dmel CG13645
gene id: 7227:Dmel_CG13645
uniprot id: A0A0B4KHH7
uniprot id: Q7KS06
uniprot id: Q9VC03
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

7227:Dmel CG33791
gene id: 7227:Dmel_CG33791
uniprot id: E1JHW5
uniprot id: Q0E8J6
uniprot id: Q95T35
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

7227:Dmel CG5618
gene id: 7227:Dmel_CG5618
uniprot id: M9PG67
uniprot id: Q9VPH6
names: Similarity
messages: Belongs to the group II decarboxylase family.

7227:Dmel CG11262
gene id: 7227:Dmel_CG11262
uniprot id: Q9VU30
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG31618
gene id: 7227:Dmel_CG31618
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG9571
gene id: 7227:Dmel_CG9571
uniprot id: Q9W5X5
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG30344
gene id: 7227:Dmel_CG30344
uniprot id: Q961H2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11865
gene id: 7227:Dmel_CG11865
uniprot id: Q9V402
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG5133
gene id: 7227:Dmel_CG5133
uniprot id: M9PBY6
uniprot id: Q9U8L5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG2819
gene id: 7227:Dmel_CG2819
uniprot id: Q9XZU0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5934
gene id: 7227:Dmel_CG5934
uniprot id: Q9VB51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

7227:Dmel CG30196
gene id: 7227:Dmel_CG30196
uniprot id: Q9W222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG7602
gene id: 7227:Dmel_CG7602
uniprot id: Q9VHV1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds nucleotide much more tightly and catalyzes nucleotide insertion much more efficiently in the presence of Mg(2+) than in the presence of Mn(2+).
messages: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11297519). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11297519). Favors Hoogsteen base-pairing in the active site (By similarity). Inserts the correct base with higher fidelity opposite an adenosine template (PubMed:11297519). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11297519). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
messages: Nucleus
messages: The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.

7227:Dmel CG1615
gene id: 7227:Dmel_CG1615
uniprot id: Q94526
uniprot id: X2JD82
uniprot id: X2JJC8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Background potassium channel. Rectification is dependent on external potassium concentration. Acts as an outwardly rectifying channel but as external potassium levels increase, this is reversed.
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Inhibited by barium.
messages: Membrane
messages: Widespread expression in adult, strongest expression in muscle, brain and ovary. Also present at low levels in larva and embryo.

7227:Dmel CG8632
gene id: 7227:Dmel_CG8632
uniprot id: A1Z935
uniprot id: A1Z936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

7227:Dmel CG8335
gene id: 7227:Dmel_CG8335
uniprot id: A1Z6K7
uniprot id: H1UU98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm

7227:Dmel CG11856
gene id: 7227:Dmel_CG11856
uniprot id: A0A0B4K7J2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RanBP2 E3 ligase family.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:27979731, PubMed:17682050, PubMed:17682050). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).
messages: Expressed during embryogenesis (at protein level).
messages: Expressed in both oocytes and nurse cells (at protein level).
messages: Part of the nuclear pore complex (By similarity). Forms a complex with Nxt1, sbr/Nxf1 and RanGAP (PubMed:14729961). Interacts (via TPR repeats) with Hsp83; the interaction is required for the nuclear import of the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731). Interacts (via N-terminus) with piwi (PubMed:29735528).
messages: RNAi-mediated knockdown abolishes embryonic development (PubMed:31626769). RNAi-mediated knockdown in the larval fat body reduces the levels of importin beta and disrupts the nuclear import of the sesquiterpenoid juvenile hormone receptor Met and juvenile hormone signal transduction (PubMed:27979731). RNAi-mediated knockdown in the germarium results in failed piwi localization to the nucleus, failed transposon silencing and piRNA biogenesis, increased DNA damage levels and overall defective ovaries (PubMed:29735528). RNAi-mediated knockdown in egg chambers reduces numbers of annulate lamellae containing nuclear pore complex components (PubMed:31626769).
messages: nuclear pore complex

7227:Dmel CG4147
gene id: 7227:Dmel_CG4147
uniprot id: F3YDH0
uniprot id: P29844
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: AMPylation at Thr-518 by Fic inactivates the chaperome activity (PubMed:25395623, PubMed:29089387). In response to endoplasmic reticulum stress, de-AMPylation by the same protein, Fic, restores the chaperone activity (PubMed:29089387).
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity).
messages: Endoplasmic reticulum lumen
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP.
messages: Was initially thought to be AMPylated at 'Thr-366' by Fic (PubMed:25395623). However, it was later shown to be AMPylated at 'Thr-518'.

7227:Dmel CG11981
gene id: 7227:Dmel_CG11981
uniprot id: C0MJU2
uniprot id: Q9XYN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG5632
gene id: 7227:Dmel_CG5632
uniprot id: M9PEZ4
uniprot id: Q9VTV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat THOC6 family.
messages: Part of the THO complex containing HPR1, THOC2, THOC5, THOC6 and THOC7.
messages: The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.

7227:Dmel CG4953
gene id: 7227:Dmel_CG4953
uniprot id: Q95TN1
names: Similarity
messages: Belongs to the TRAPPC13 family.

7227:Dmel CG8553
gene id: 7227:Dmel_CG8553
uniprot id: O18373
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the selenophosphate synthase 1 family. Class II subfamily.
messages: Expressed at low levels throughout the embryo. At later developmental stages, expressed in areas of high cell proliferation. From embryo stage 13, expression is high in central nervous system and midgut, especially in the gastric caeca. Expression also seen in larval imaginal disks and brain.
messages: Plays a role in apoptosis and consequently a role in imaginal disk patterning and growth.
messages: The conserved active site Cys (or selenocysteine) residue in position 49 is replaced by an Arg and therefore lacks selenide-dependent monoselenophosphate synthetase activity.
messages: Throughout development, from embryo to adult.

7227:Dmel CG6495
gene id: 7227:Dmel_CG6495
uniprot id: Q9Y110
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG12159
gene id: 7227:Dmel_CG12159
uniprot id: A1Z765
uniprot id: Q8MSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

7227:Dmel CG10124
gene id: 7227:Dmel_CG10124
uniprot id: Q9VRY0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7227:Dmel CG8947
gene id: 7227:Dmel_CG8947
uniprot id: Q9V3U6
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG9159
gene id: 7227:Dmel_CG9159
uniprot id: Q9V447
uniprot id: X2J4W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Member of the dosage-dependent hierarchy effective upon white gene expression.
messages: Membrane

7227:Dmel CG3590
gene id: 7227:Dmel_CG3590
uniprot id: Q9VEP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

7227:Dmel CG31111
gene id: 7227:Dmel_CG31111
uniprot id: Q8IMU0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8967
gene id: 7227:Dmel_CG8967
uniprot id: Q6AWJ9
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.
messages: Axon guidance defects. R-cell differentiation and cell fate determination are normal, but many R1-R6 axons connect abnormally to medulla instead of innervating lamina.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Dynamically expressed during embryogenesis in several areas of the developing nervous system, including neurons and fasciculating axons. Expression in stage 7 embryos is seen in the anterior midgut primordia, cephalic furrow and along the germinal band. At stage 11, expression is in 15 stripes over the trunk region, and in the anterior and posterior midgut primordia. Stage 12 shows expression in the developing nervous system, procephalic lobe and maxillar bud. Stage 13 shows expression in the ventral cord, maxillar segment and in three regions of the gut. At stage 16 expression is preferentially detected throughout the nervous system, including the neuromers in the ventral cord and the supraesophageal ganglion (at protein level). In larva, expression is seen in developing R cells and is localized predominantly to R1-R6 growth cones.
messages: Expressed both maternally and zygotically, during early to mid embryogenesis and early pupation.
messages: Interacts with plexA; component of a receptor complex that mediates the repulsive signaling in response to Semaphorin ligands.
messages: This protein has been proposed to undergo autophosphorylation on tyrosine residues which is induced in response to cell adhesion (PubMed:1371458). However, as mammalian orthologs of this protein seem to lack kinase activity this protein may associate with, and be phosphorylated by, an unknown active tyrosine kinase.

7227:Dmel CG15551
gene id: 7227:Dmel_CG15551
uniprot id: Q9VA22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

7227:Dmel CG9015
gene id: 7227:Dmel_CG9015
uniprot id: P02836
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the engrailed homeobox family.
messages: Expression initiates prior to the ninth embryonic nuclear division cycle within 1.5 hours after fertilization. By the cellular blastoderm stage (the 14th nuclear division cycle) is localized into 14 stripes, 1-2 cells wide, spaced along the anterior-posterior axis of the embryo.
messages: Nucleus
messages: Phosphorylated. Phosphorylation may directly or allosterically modify its function.
messages: This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.

7227:Dmel CG2765
gene id: 7227:Dmel_CG2765
uniprot id: Q9W0X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG8223
gene id: 7227:Dmel_CG8223
uniprot id: Q9I7K6
names: Similarity
messages: Belongs to the NASP family.

7227:Dmel CG32664
gene id: 7227:Dmel_CG32664
uniprot id: P58950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily.
messages: Cell membrane
messages: Expressed in the medial aspect of the third antennal segment, and in neurons of the terminal external chemosensory organ of larvae.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG14618
gene id: 7227:Dmel_CG14618
uniprot id: Q9VR56
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs.

7227:Dmel CG5168
gene id: 7227:Dmel_CG5168
uniprot id: Q9VKW1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

7227:Dmel CG5076
gene id: 7227:Dmel_CG5076
uniprot id: A0A0B4LGW2
uniprot id: A1ZB14
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

7227:Dmel CG12910
gene id: 7227:Dmel_CG12910
uniprot id: F3YD52
uniprot id: Q7K2R1
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7227:Dmel CG6265
gene id: 7227:Dmel_CG6265
uniprot id: Q8IHC6
uniprot id: Q8IMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG33855
gene id: 7227:Dmel_CG33855
uniprot id: Q4AB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG10844
gene id: 7227:Dmel_CG10844
uniprot id: A0A0B4K6T5
uniprot id: A0A0B4K715
uniprot id: A0A0B4K719
uniprot id: A0A0B4K7K0
uniprot id: A0A0B4K7U9
uniprot id: A0A0B4K837
uniprot id: Q24498
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in 6-12 hours embryos, reduced expression in second and third instar larval stages and adults.
messages: Belongs to the ryanodine receptor (TC 1.A.3.1) family.
messages: Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity and maintains the channel in an open conformation. The calcium release channel is modulated by calcium ions, magnesium ions, ATP and calmodulin (By similarity).
messages: During embryonic stages 9-10, expression is seen in mesoderm of all segments in progenitors of the cephalic and somatic muscles. Adults exhibit high expression in tubular 'jump' muscles of thorax and leg, and lower expression in the brain, ventral ganglion, head muscles and proboscis muscles.
messages: Homotetramer.
messages: Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles.
messages: Membrane
messages: Sarcoplasmic reticulum membrane
messages: The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.

7227:Dmel CG6203
gene id: 7227:Dmel_CG6203
uniprot id: A0A0B4K618
uniprot id: A0A0B4KFN9
uniprot id: A0A0B4KGP6
uniprot id: A0A126GUS7
uniprot id: B3LF78
uniprot id: Q9NFU0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FMR1 family.
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Expressed during the embryonic development (PubMed:11046149). Expressed both maternally and zygotically in embryos (PubMed:11046149). Until early gastrulation, expression is uniformly distributed in the embryo (PubMed:11046149). At mid-gastrulation (stage 11), expressed everywhere with discernible concentration in the mesoderm (PubMed:11046149). After gastrulation (stage 14), expressed in the mesoderm, ventral nerve cord, and brain (PubMed:11046149). At stage 16, elevated expression is also seen in the muscle (PubMed:11046149). Highly expressed in nervous system throughout later development (at protein level) (PubMed:11046149, PubMed:11733059).
messages: Highly expressed in testes in the early stages of spermatogenesis before spermatid individualization (at protein level) (PubMed:15183715).
messages: Homodimer (PubMed:11046149). Interacts with AGO2, Dcr-1, Rm62, vig, RpL5 and RpL11; these interactions form the RNA-induced silencing complex (RISC), a messenger ribonucleoprotein particle (RNP) complex involved in translation regulation (PubMed:12368261, PubMed:14508492). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492). Component of a neuronal RNP at least composed of Fmr1, tral and me31B (PubMed:17178403). Interacts with piwi and vas; these interactions occur in the polar granules (PubMed:16949822). Interacts with Sra-1 (PubMed:12818175). Associates with polyribosome (PubMed:12368261). Interacts with Ythdf; the interaction is RNA independent (PubMed:33428246).
messages: Perikaryon
messages: Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs (PubMed:11046149, PubMed:11733059, PubMed:12368261, PubMed:17178403). Plays a role as a negative translational regulator of specific mRNAs (PubMed:11733059, PubMed:17178403). Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function (PubMed:11733059). Localizes to specific N6-methyladenosine (m6A)-containing RNAs as part of a complex with the m6A reader Ythdf and thereby regulates axonal growth in the mushroom bodies and neuromuscular junctions (PubMed:33428246). May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC) (PubMed:12368261, PubMed:14508492). Required for stability of the central pair of microtubules in the spermatid axoneme (PubMed:15183715). Regulates photoreceptor structure and neuromuscular junction (NMJ) neurotransmission in the eye (PubMed:11733059, PubMed:17178403). During embryogenesis, involved in germline fate determination (PubMed:16949822).
messages: Stress granule
messages: Synapse
messages: neuron projection

7227:Dmel CG5023
gene id: 7227:Dmel_CG5023
uniprot id: Q9I7J0
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7227:Dmel CG3788
gene id: 7227:Dmel_CG3788
uniprot id: Q8T8S2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

7227:Dmel CG4039
gene id: 7227:Dmel_CG4039
uniprot id: C6SUY3
uniprot id: Q9V461
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation. Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable). The heterodimers of Mcm4/Mcm6 and Mcm3/Mcm5 interact with Mcm2 and Mcm7.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Expressed both maternally and zygotically.
messages: In stage 12 embryos, strongly expressed in the CNS and weakly in the gut.
messages: Nucleus

7227:Dmel CG5231
gene id: 7227:Dmel_CG5231
uniprot id: Q7JQW6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7227:Dmel CG10084
gene id: 7227:Dmel_CG10084
uniprot id: Q9VIV2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in precellular embryo along the ventral midline and, in germ-band retraction embryos, in segmental stripes. Expressed in third instar larvae in imaginal disks, salivary gland, optic lobe, fat body, wreath cells and gastric caecae of the gut.
messages: Negatively regulates Hedgehog (hh) protein signal in wing development (PubMed:18245841). Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496).
messages: Nucleus
messages: Recessive lethal (PubMed:18245841). Heteroallelic larvae are severely developmentally delayed and most have wing disks smaller than wild-type (PubMed:18245841). Heteroallelic adult flies show defects in wing hair orientation (PubMed:18245841). Defective alpha-1,3-fucosylation (PubMed:21203496). RNAi-mediated knockdown in the eye results in reduced FucTA protein levels (PubMed:21203496).

7227:Dmel CG1867
gene id: 7227:Dmel_CG1867
uniprot id: Q9VAW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG42553
gene id: 7227:Dmel_CG42553
uniprot id: Q9W0M6
names: Similarity
messages: Belongs to the UPF0415 family.

7227:Dmel CG32072
gene id: 7227:Dmel_CG32072
uniprot id: Q5JZZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG6007
gene id: 7227:Dmel_CG6007
uniprot id: H5V8A8
uniprot id: Q9VE09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

7227:Dmel CG10754
gene id: 7227:Dmel_CG10754
uniprot id: Q9VU15
names: Similarity
messages: Belongs to the SF3A2 family.

7227:Dmel CG1430
gene id: 7227:Dmel_CG1430
uniprot id: P51406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bystin family.
messages: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
messages: nucleolus

7227:Dmel CG33843
gene id: 7227:Dmel_CG33843
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG31115
gene id: 7227:Dmel_CG31115
uniprot id: Q8IMU4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus
messages: Purine nucleoside phosphorylase involved in purine salvage.

7227:Dmel CG10899
gene id: 7227:Dmel_CG10899
uniprot id: C8VV79
uniprot id: Q8IMV4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG9476
gene id: 7227:Dmel_CG9476
uniprot id: P06604
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

7227:Dmel CG8205
gene id: 7227:Dmel_CG8205
uniprot id: Q9BJZ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Death during embryogenesis; without displaying dorsal-ventral patterning defects. Heterozygous embryos act as a dominant maternal enhancer of dorsalizing mutation cact(E10) and display a partially dorsalized phenotype.
messages: Not present in the oocyte or early embryo. Expressed in a number of embryonic tissues at later stages. First detected at stage 9 of embryogenesis, in the epithelium of the stomodeum, which develops into the foregut and in the epithelium of the proctodeal opening. Segmentally repeated expression was observed in the mesodermal layer in stage 11. At stage 13, segmentally repeated ectodermal expression is observed. Also expressed in the epithelium of the foregut and posterior spiracles and the fat body. Detected in both nurse cells and follicle cells during oogenesis. Enriched in follicle cells adjacent to the anterior end of the oocyte.
messages: Nucleus
messages: mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator.

7227:Dmel CG8705
gene id: 7227:Dmel_CG8705
uniprot id: P40797
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulates at the leading edge of the cleavage furrow in dividing cells and cellularizing embryos (at protein level).
messages: Apical cell membrane
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Involved in cytokinesis and possibly cellularization (PubMed:8181057). Also acts as an enhancer of the sina gene, thus having a role in photoreceptor development (PubMed:8181057). May be involved in p53-dependent apoptosis (PubMed:17456438).
messages: Likely part of a multicomponent septin complex that includes Septin1 (PubMed:8590810). Interacts with Septin1 (PubMed:8590810). Interacts with hil (PubMed:15818553). Interacts with park (PubMed:17456438).
messages: Maternal gene products found in the early embryo prior to zygotic transcription.
messages: Ubiquitinated by park, leading to its degradation by the proteasome.
messages: cell cortex

7227:Dmel CG7211
gene id: 7227:Dmel_CG7211
uniprot id: Q9VLY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

7227:Dmel CG11164
gene id: 7227:Dmel_CG11164
uniprot id: Q9VYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

7227:Dmel CG5451
gene id: 7227:Dmel_CG5451
uniprot id: Q9VE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

7227:Dmel CG34194
gene id: 7227:Dmel_CG34194
uniprot id: A8DYH6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG9075
gene id: 7227:Dmel_CG9075
uniprot id: C9QP42
uniprot id: Q02748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas.

7227:Dmel CG12755
gene id: 7227:Dmel_CG12755
uniprot id: P52302
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Blood cells and other tissues.
messages: Cytoplasm
messages: Intron retention.
messages: Required for differentiation of the phagocytic blood-cell type, the plasmatocyte.
messages: perinuclear region

7227:Dmel CG5219
gene id: 7227:Dmel_CG5219
uniprot id: Q9VPF6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

7227:Dmel CG17209
gene id: 7227:Dmel_CG17209
uniprot id: A8JUY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

7227:Dmel CG43286
gene id: 7227:Dmel_CG43286
uniprot id: A0A0B4K6E1
uniprot id: A0A0B4K6G8
uniprot id: A0A0B4K6Z0
uniprot id: A0A0B4KGT0
uniprot id: A0A0B4KHP5
uniprot id: P20482
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bZIP family. CNC subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Embryonic expression of isoform B is localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Embryonic expression of isoforms B and C is ubiquitous.
messages: Isoforms A and C are maternally and zygotically expressed in embryos. Isoform A reduced between 2-12 hours embryos and then increases. Isoform B is expressed in later embryonic stages. Isoform C has the lowest expression level of the isoforms.
messages: Nucleus
messages: Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.

7227:Dmel CG5721
gene id: 7227:Dmel_CG5721
uniprot id: Q7K486
names: Similarity
messages: Belongs to the ARMC6 family.

7227:Dmel CG9961
gene id: 7227:Dmel_CG9961
uniprot id: M9PE85
uniprot id: Q9VQF4
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

7227:Dmel CG13895
gene id: 7227:Dmel_CG13895
uniprot id: M9PDR6
uniprot id: Q9W0N4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8351
gene id: 7227:Dmel_CG8351
uniprot id: Q9VHL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

7227:Dmel CG11534
gene id: 7227:Dmel_CG11534
uniprot id: Q9VTT9
names: Similarity
messages: Belongs to the DEF8 family.

7227:Dmel CG11137
gene id: 7227:Dmel_CG11137
uniprot id: Q9VNQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG6712
gene id: 7227:Dmel_CG6712
uniprot id: Q9VKB4
names: Function
names: Subcellular Location Annotation
messages: May be required for ribosome biogenesis.
messages: nucleolus

7227:Dmel CG11334
gene id: 7227:Dmel_CG11334
uniprot id: A0A0B4KI38
uniprot id: Q9V9X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG32832
gene id: 7227:Dmel_CG32832
uniprot id: Q8INZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG13914
gene id: 7227:Dmel_CG13914
uniprot id: Q9W0G7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle.
messages: Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:19684111, PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules (PubMed:19684111).
messages: Viable but females are sterile. Mutant embryos show increased mitotic spindle length during metaphase and reduced mitotic spindle density.
messages: spindle

7227:Dmel CG15237
gene id: 7227:Dmel_CG15237
uniprot id: Q4V665
names: Similarity
messages: Belongs to the APC15 family.

7227:Dmel CG30371
gene id: 7227:Dmel_CG30371
uniprot id: A1Z7D2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7434
gene id: 7227:Dmel_CG7434
uniprot id: P50887
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

7227:Dmel CG6017
gene id: 7227:Dmel_CG6017
uniprot id: M9PFE4
uniprot id: Q9VUW9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Golgi apparatus membrane
messages: In stage 13-15 embryos, expressed in the central nervous system. At the third instar larval stage, expressed in the ventral nerve cord and is enriched in the neuropil.
messages: Interacts with dorsal-ventral patterning protein Sog.
messages: Membrane
messages: Presynaptic cell membrane
messages: Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25 (PubMed:18158335, PubMed:18032660). Probably palmitoylates Csp (PubMed:18158335). Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form (PubMed:20599894). Required for synaptic vesicle exocytosis (PubMed:18158335).
messages: RNAi-mediated knockdown causes reduced basal secretion of Sog.
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG12770
gene id: 7227:Dmel_CG12770
uniprot id: A0A0B4KF05
uniprot id: Q9V359
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
messages: Death at the transition from the first to second instar. Morphological changes in MVBs and developmental defects in the compound eye. However, for the ligands and receptors tested, changes in their cell surface levels or their delivery to lysosomes have not been detected. In early embryos and during sperm individualization defects in actin cytoskeleton organization ocurr.
messages: Endosome

7227:Dmel CG17446
gene id: 7227:Dmel_CG17446
uniprot id: M9MS35
uniprot id: Q9W352
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1.
messages: Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1.
messages: Nucleus

7227:Dmel CG14898
gene id: 7227:Dmel_CG14898
uniprot id: A0A1B2AJN1
uniprot id: Q8SZ16
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with SdhB within an SdhA-SdhB subcomplex.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SdhB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
messages: Reduces the SdhB protein level resulting in an approximate 50% reduction in SDH enzymatic activity.

7227:Dmel CG1934
gene id: 7227:Dmel_CG1934
uniprot id: P29681
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates.
messages: Produced during mid embryogenesis, and imaginal disk morphogenesis.
messages: Secreted
messages: The regions 203-253, 256-333 and 335-377 are thought to contain either alpha helical or beta pleated sheet motifs.

7227:Dmel CG33303
gene id: 7227:Dmel_CG33303
uniprot id: Q76NQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7227:Dmel CG43479
gene id: 7227:Dmel_CG43479
uniprot id: X2JAU8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex (PubMed:18701694, PubMed:27601635). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation (PubMed:23761074, PubMed:26686642). Required for normal structure and function of synapses at the neuromuscular junction (PubMed:18701694, PubMed:14980202, PubMed:18498733, PubMed:21464232, PubMed:26686642, PubMed:26567222, PubMed:27601635, PubMed:29568072). Plays a role in synaptic vesicle trafficking (PubMed:29568072). Required for the release of a normal number of synaptic vesicles per action potential (PubMed:26567222).
messages: Detected in embryonic brain, ventral nerve cord and sensory neurons, but not in muscle.
messages: Detected in larval body wall muscle (PubMed:29568072). Detected at the neuromuscular junction, on motoneuron axons and axon terminals, at synaptic boutons in the periactive zone surrounding the synapse (at protein level) (PubMed:14980202, PubMed:29568072). Detected on motoneuron axons and axon terminals, at synaptic boutons in the periactive zone surrounding the synapse (PubMed:26686642).
messages: Endomembrane system
messages: Homodimer (Probable) (PubMed:27601635). Interacts (via SH3 domain 1) with WASp (PubMed:14980202, PubMed:18701694, PubMed:27601635). Interacts (via SH3 domain 1) with shi/dynamin (PubMed:18701694, PubMed:18498733). Interacts (via SH3 domain 2) with Dap160 (PubMed:18701694, PubMed:18498733, PubMed:26686642). Interacts (via F-BAR domain) with SH3PX1 (PubMed:26567222). Interacts (via SH3 domain 2) with Snx16 (PubMed:21464232). Identified in a complex with Syn and Syt1 (PubMed:29568072).
messages: In the autoinhibited state, the SH3 domains are bound to the concave surface of the F-BAR domain and prevent promiscuous membrane binding.
messages: No visible phenotype in adults at room temperature, but flies rapidly loose coordination and become paralyzed within three minutes at 38 degrees Celsius (PubMed:14980202). Larvae display overgrowth of neuromuscular junctions, with increased numbers of synaptic boutons and increased frequency and complexity of axon branching (PubMed:14980202, PubMed:18701694, PubMed:18498733, PubMed:21464232, PubMed:26686642, PubMed:29568072). The synaptic area and the number of reserve and readily releasable synaptic vesicles are decreased (PubMed:29568072).
messages: Presynaptic cell membrane
messages: Recycling endosome
messages: Synapse
messages: Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions (PubMed:23761074, PubMed:26686642). Contrary to F-BAR domains from other proteins, causes membrane flattening on giant unilamellar vesicles (in vitro) (PubMed:23761074, PubMed:26686642). Binds to membranes enriched in phosphatidylserine and phosphatidylinositides, such as phosphatidylinositol 3-phosphate, phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (PubMed:23761074, PubMed:26686642, PubMed:27601635).
messages: axon
messages: synaptic vesicle

7227:Dmel CG32417
gene id: 7227:Dmel_CG32417
uniprot id: Q9NI63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins (PubMed:11882391, PubMed:12072468, PubMed:15581871). Mediates phosphorylation of Cdk1 predominantly on 'Thr-14' (PubMed:11882391). Also involved in Golgi fragmentation (PubMed:11882391). May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:11882391). May be a downstream target of Notch signaling pathway during eye development (PubMed:12072468).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Golgi apparatus membrane

7227:Dmel CG4241
gene id: 7227:Dmel_CG4241
uniprot id: A0A0B4LIE8
uniprot id: Q8IN53
uniprot id: Q9VDL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG6264
gene id: 7227:Dmel_CG6264
uniprot id: A0A0B4K651
uniprot id: A0A0B4KGQ2
uniprot id: B7Z0U6
uniprot id: Q9V3J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7227:Dmel CG18660
gene id: 7227:Dmel_CG18660
uniprot id: M9MRG0
uniprot id: M9PCP1
uniprot id: Q9U6A0
names: Developmental Stage
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed during ventral nerve cord development in the embryo and in larval imaginal disks. Expressed in a dorsal-ventral pattern in the eye-antennal disk.
messages: Expressed in the adult nervous system. Expressed in the photoreceptor cells as well as in the lamina, medulla, and optic lobes of the brain.
messages: May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+).
messages: Membrane
messages: Partially edited. Target of Adar.

7227:Dmel CG10590
gene id: 7227:Dmel_CG10590
uniprot id: Q9VRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

7227:Dmel CG15101
gene id: 7227:Dmel_CG15101
uniprot id: Q7JRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Catalyzes juvenile hormone hydrolysis.
messages: Endoplasmic reticulum membrane

7227:Dmel CG2060
gene id: 7227:Dmel_CG2060
uniprot id: A0A0B4LFT2
uniprot id: Q27606
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG7860
gene id: 7227:Dmel_CG7860
uniprot id: B4F5C5
uniprot id: Q9VXT7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
messages: Heterodimer of an alpha and beta chain produced by autocleavage.

7227:Dmel CG13926
gene id: 7227:Dmel_CG13926
uniprot id: Q9W0C7
names: Similarity
messages: Belongs to the OPI10 family.

7227:Dmel CG10834
gene id: 7227:Dmel_CG10834
uniprot id: Q9V9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

7227:Dmel CG4550
gene id: 7227:Dmel_CG4550
uniprot id: P06002
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
messages: photoreceptor outer segment

7227:Dmel CG14746
gene id: 7227:Dmel_CG14746
uniprot id: C0HK98
uniprot id: C0HK99
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Constitutively expressed at high level in gut, in addition to the induced expression in fat body.
messages: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN) (PubMed:11106397, PubMed:12496260). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments (PubMed:12496260). Has no direct bacteriolytic activity (PubMed:12496260).
messages: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
messages: Secreted
messages: Up-regulated by PGN from B.subtilis.

7227:Dmel CG8673
gene id: 7227:Dmel_CG8673
uniprot id: Q9VLT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG11475
gene id: 7227:Dmel_CG11475
uniprot id: Q9W2A0
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

7227:Dmel CG12263
gene id: 7227:Dmel_CG12263
uniprot id: A1ZB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG15779
gene id: 7227:Dmel_CG15779
uniprot id: Q9W497
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in labellar chemosensory neurons.
messages: Flies exhibit trehalose-specific physiological and behavioral defects (reduced response by chemosensory neurons of the labellar taste hairs).
messages: Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A.
messages: Variant Thr-218 was found to be the ancestral form in D.melanogaster, suggesting that low trehalose sensitivity was an ancestral form with respect to the receptor function.

7227:Dmel CG10188
gene id: 7227:Dmel_CG10188
uniprot id: M9PBE1
uniprot id: Q9VIV0
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG10071
gene id: 7227:Dmel_CG10071
uniprot id: A0A1B2AJK8
uniprot id: Q24154
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

7227:Dmel CG7846
gene id: 7227:Dmel_CG7846
uniprot id: Q9VX09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Component of the chromatin remodeling Ino80 complex. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).
messages: cytoskeleton

7227:Dmel CG1945
gene id: 7227:Dmel_CG1945
uniprot id: A0A0B4K6W2
uniprot id: A0A0B4K7S0
uniprot id: P55824
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Expressed both maternally and zygotically.
messages: Eye disks and ovaries (PubMed:1295747). Expressed in larval fat body (PubMed:23919485).
messages: Interacts with imd.
messages: Ubiquitin C-terminal hydrolase involved in development and the imd/NF-kappa-B (IMD) signaling cascade (PubMed:23919485, PubMed:1295747). Required for eye and embryo development, and plays a role in compound eye assembly and oogenesis respectively (PubMed:1295747). In the larval eye disks, cells outside the assembling facets require this protein for short-range cell interactions that prevent the mystery cells from becoming photoreceptors (PubMed:1295747). Also required for nuclear migration and cellularization in early embryogenesis and could play a role in pole cell determination, development or function (PubMed:1295747). Regulates the IMD signaling cascade at later stages of infection (around 6 hours post-infection) by inhibiting the expression of the antimicrobial peptides Dpt and Dro (PubMed:23919485). Acts by modulating the state of imd polyubiquitination and/or stability; a function which appears to be independent of its enzymatic activity (PubMed:23919485). In turn, imd enhances the polyubiquitination and stability of faf suggesting that they may form a regulatory feedback mechanism within the Imd pathway (PubMed:23919485).
messages: Ubiquitinated. Ubiquitination is enhanced by the expression of imd.

7227:Dmel CG1698
gene id: 7227:Dmel_CG1698
uniprot id: Q7K330
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG4934
gene id: 7227:Dmel_CG4934
uniprot id: Q24157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation.

7227:Dmel CG10467
gene id: 7227:Dmel_CG10467
uniprot id: Q9VRU1
names: Similarity
messages: Belongs to the aldose epimerase family.

7227:Dmel CG5263
gene id: 7227:Dmel_CG5263
uniprot id: Q23972
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Absence of a large region from Gly-793 to the end of the coding region that changes the frame.
messages: At syncytial blastoderm, it is located throughout the bulk cytoplasm and pole plasm. By the time of cellularization, it concentrates at the posterior pole.
messages: Belongs to the SMAUG family.
messages: Cytoplasm
messages: Expressed maternally. The protein accumulates during the first 3 hours after fertilization, and then decreases rapidly.
messages: Interacts with oskar (osk). Binds to the 3'-UTR of nos. Interacts with cup, which in turn recruits eIF4-E, leading to an indirect interaction between smg and eIF4-E that prevents mRNA translation. Forms a complex with aub, twin, AGO3, nos mRNA and piRNAs that targets the nos 3'-untranslated region, in early embryos.
messages: The SAM domain mediates the association with the 3'-UTR of specific mRNAs.
messages: Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation. Prevents translation of unlocalized nos in the bulk cytoplasm via the recruitment of cup.

7227:Dmel CG15254
gene id: 7227:Dmel_CG15254
uniprot id: Q9V3M3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG31136
gene id: 7227:Dmel_CG31136
uniprot id: A0A0B4JCZ4
uniprot id: A0A126GV04
uniprot id: Q24547
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Expressed throughout development.
messages: Lysosome membrane
messages: Membrane
messages: Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:7834751). Essential for embryonic viability and development (PubMed:7834751). Required for coordinated peristaltic contractions (PubMed:7834751). Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens in tracheal fusion cells (Fcs) by interacting with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells (PubMed:27323327).
messages: Prior to embryonic stage 12 expression is ubiquitous, then it becomes concentrated in the neuropil. In third instar larvae, expression is seen at the synaptic boutons of the ventral muscles. In adult brain, expression is seen in the optic lobe neuropils.
messages: synaptic vesicle membrane

7227:Dmel CG7371
gene id: 7227:Dmel_CG7371
uniprot id: Q9VMQ8
names: Similarity
messages: Belongs to the VPS52 family.

7227:Dmel CG5862
gene id: 7227:Dmel_CG5862
uniprot id: Q9VDD1
names: Function
names: Similarity
messages: Belongs to the DDRGK1 family.
messages: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins.

7227:Dmel CG44243
gene id: 7227:Dmel_CG44243
uniprot id: Q8SX78
names: Similarity
messages: Belongs to the LplA family.

7227:Dmel CG7816
gene id: 7227:Dmel_CG7816
uniprot id: A4V3L8
uniprot id: Q9VAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Golgi apparatus membrane
messages: Involved in zinc transport and homeostasis.
messages: Membrane

7227:Dmel CG11291
gene id: 7227:Dmel_CG11291
uniprot id: Q9W272
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG32463
gene id: 7227:Dmel_CG32463
uniprot id: Q8IPZ0
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7227:Dmel CG13076
gene id: 7227:Dmel_CG13076
uniprot id: Q9VUX3
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pectinacetylesterase family. Notum subfamily.
messages: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling (PubMed:20412775, PubMed:22872085).
messages: Cell surface
messages: Expression is induced by Wnt.
messages: Secreted
messages: The molecular function of NOTUM has remained unclear for many years. It was initially thought to hydrolyze glycosaminoglycan (GAG) chains of glypicans, thereby affecting glypicans ability to interact with Wnt ligands (PubMed:12015973, PubMed:12000788). It was later reported to trigger glypican shedding, by mediating cleavage of their GPI-anchor (PubMed:15469839). However, while NOTUM specifically inhibit the Wnt signaling pathway, more pleiotropic effects would be expected from an enzyme affecting glypicans. It was finally shown that it requires glypicans to suppress Wnt signaling, but does not cleave their GPI-anchor (PubMed:25731175). It acts by mediating depalmitoleoylation of WNT proteins, impairing WNT binding to frizzled receptors (PubMed:25731175).

7227:Dmel CG12002
gene id: 7227:Dmel_CG12002
uniprot id: Q9VZZ4
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.
messages: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (PubMed:22842973). Plays a role in extracellular matrix consolidation, phagocytosis and defense (PubMed:8062820).
messages: Expressed in hemocytes. Also expressed in the fat body and gastric caeca.
messages: Expressed throughout embryonic and larval development. Expressed in hemocytes as they migrate in the early embryo and later in embryogenesis, become localized to basement membranes.
messages: Homotrimer; disulfide-linked.
messages: Secreted

7227:Dmel CG17218
gene id: 7227:Dmel_CG17218
uniprot id: Q9VKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG11495
gene id: 7227:Dmel_CG11495
uniprot id: H0RNG9
uniprot id: Q9VZU2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
messages: Expressed both maternally and zygotically.
messages: Membrane
messages: Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling.

7227:Dmel CG8790
gene id: 7227:Dmel_CG8790
uniprot id: Q9Y166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG31381
gene id: 7227:Dmel_CG31381
uniprot id: Q8IMV0
names: Similarity
messages: Belongs to the IPP transferase family.

7227:Dmel CG4859
gene id: 7227:Dmel_CG4859
uniprot id: A0A0B4JCU7
uniprot id: A0A0B4JD53
uniprot id: A0A0B4JDA7
uniprot id: A0A0B4K7H5
uniprot id: Q8MLN6
uniprot id: Q9W122
names: Similarity
messages: Belongs to the peptidase M10A family.

7227:Dmel CG7834
gene id: 7227:Dmel_CG7834
uniprot id: Q0KHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

7227:Dmel CG33892
gene id: 7227:Dmel_CG33892
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG4291
gene id: 7227:Dmel_CG4291
uniprot id: Q9VPU4
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG31421
gene id: 7227:Dmel_CG31421
uniprot id: P83104
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

7227:Dmel CG8863
gene id: 7227:Dmel_CG8863
uniprot id: Q9VFV9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6385
gene id: 7227:Dmel_CG6385
uniprot id: A1ZAZ2
names: Similarity
messages: Belongs to the GcvT family.

7227:Dmel CG4918
gene id: 7227:Dmel_CG4918
uniprot id: P05389
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

7227:Dmel CG11313
gene id: 7227:Dmel_CG11313
uniprot id: A0A0B4KI65
uniprot id: Q9VA44
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Secreted
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG6677
gene id: 7227:Dmel_CG6677
uniprot id: Q94545
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6. Interacts with hcf, sktl and trr.
messages: Expressed in larval and pupal stages (at protein level). Expression also detected at early embryonic stages and in adult.
messages: Generally pupal-lethal with mutants showing a wide array of homeotic transformations. Adult escapers are sterile and show pattern formation abnormalities in legs, including tissue overgrowth and small supernumerary legs. In wings, the pattern formation defects observed include duplicated bristles and sockets, transformation of campaniform sensilla (a class of sensory organ) to bristles, ectopic campaniform sensilla and reduction of intervein tissue with increase of longitudinal veins and cross-vein tissue. Mutant wing imaginal disk shows ectopic expression of neur, normally expressed in all sensory organ precursors in the posterior region of the wing disk. Increased histone H1 hyperphosphorylation in polytene chromosomes. Reduced trimethylation of histone H3 'Lys-4', reduced levels of trr protein and severe defects in pupariation and metamorphosis due to a lack of activation of ecdysone-responsive genes.
messages: In larvae and pupae, expressed in imaginal disks, salivary gland and fat body cells. No expression detected in central nervous system (at protein level).
messages: Intron retention.
messages: Nucleus
messages: Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of transcriptionally active chromatin through down-regulation of histone H1 hyperphosphorylation.

7227:Dmel CG4029
gene id: 7227:Dmel_CG4029
uniprot id: Q9XTP7
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG16742
gene id: 7227:Dmel_CG16742
uniprot id: A1ZBW7
names: Function
names: Similarity
names: Subunit
messages: Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting.
messages: Belongs to the FAM21 family.
messages: Component of the WASH complex.

7227:Dmel CG9722
gene id: 7227:Dmel_CG9722
uniprot id: Q9VFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7227:Dmel CG12052
gene id: 7227:Dmel_CG12052
uniprot id: P42283
uniprot id: P42284
uniprot id: Q7KQZ4
uniprot id: Q867Z4
uniprot id: Q9V5M3
uniprot id: Q9V5M6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By stage 11, isoform B is expressed throughout the mesoderm, whereas isoform A, isoform D and isoform L are expressed throughout the ectoderm. Expression becomes restricted during later stages; starting from stage 14 to 16, isoform B is expressed in muscle. Isoform A, isoform D, and at low levels isoform B, are expressed in the CNS. Expression is also seen in specific types of cells in the embryo; isoform A and isoform L are expressed in a dynamic pattern in the ventral neurogenic region starting at stage 7. Isoform L is expressed around the tracheal pits at stage 11.
messages: By stage 11, isoform F is expressed throughout the mesoderm whereas isoform T, and at low levels isoform I, is expressed throughout the ectoderm. Isoform K is expressed in both mesoderm and ectoderm. Expression becomes restricted during later stages; starting from stage 14 to 15, isoform F is expressed in the gut. Isoform I is expressed in the CNS. Isoform I and isoform F show expression in the epithelium starting at stage 14, though for isoform I the CNS expression remains predominant. Expression is also seen in specific types of cells in the embryo; isoform K is expressed in the ventral furrow at stage 5 and in a dynamic pattern in the ventral neurogenic region starting at stage 7. Isoform T is expressed around the tracheal pits at stage 11. Isoform F shows transient enrichment in a dorsal cell layer in the CNS at stages 13 and 14.
messages: By stage 11, isoform Q, isoform P and isoform Z are expressed throughout the mesoderm. From stage 15, expression of isoform P expands to all tissues, whereas expression of isoform Z and isoform Q becomes restricted during later stages; starting from stage 14 to 16, isoform Z is expressed in muscle, and isoform Q and isoform Z are expressed in the CNS. For some isoforms, expression is also seen in specific types of cells in the embryo; isoform Z is expressed in the ventral furrow at stage 5, and isoform Q is expressed around the tracheal pits at stage 11. Isoform Z also shows transient enrichment in a dorsal cell layer in the CNS at stages 13 and 14.
messages: By stage 11, isoform W, isoform X and isoform Y are expressed throughout the mesoderm, whereas isoform O is expressed in both mesoderm and ectoderm. From stage 15, expression of isoform O expands to all tissues, whereas expression of isoform W, isoform X and isoform Y becomes restricted during later stages; starting from stage 14 to 16, isoform W, isoform X and isoform Y are expressed in muscle. From stages 14 and 15, isoform W and isoform Y are expressed in the gut. For some isoforms, expression is also seen in specific types of cells in the embryo; isoform O is expressed in the ventral furrow at stage 5 and in the dorsal epidermis from stage 7. Isoform Y shows prominent expression in the gonad starting at stage 15.
messages: C-terminal exons may be joined by a trans-splicing event. The exons are coded by the same DNA strand.
messages: Expressed both maternally and zygotically. At least one isoform is present at each developmental stage.
messages: Expressed both maternally and zygotically. At least one isoform is present at each developmental stage. Isoform D is restricted to early embryogenesis (at protein level).
messages: Expressed in both mesoderm and ectoderm with expression highest in the mesectoderm by stage 11. Becomes enriched in a cluster of brain cells, in abdominal histoblasts, and in the embryonic imaginal disks during later stages.
messages: Isoform D interacts with JIL-1.
messages: Mostly neuronal.
messages: Nucleus
messages: Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.

7227:Dmel CG30427
gene id: 7227:Dmel_CG30427
uniprot id: Q0E8W1
uniprot id: Q8MMC6
uniprot id: Q9W0Y5
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG9854
gene id: 7227:Dmel_CG9854
uniprot id: A0A0B4KG96
uniprot id: Q9N6D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

7227:Dmel CG15737
gene id: 7227:Dmel_CG15737
uniprot id: Q9VYS4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
messages: Cytoplasm
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle. Required at the final stage of oogenesis for meiosis I metaphase arrest and for progression beyond this stage.
messages: Expressed both maternally and zygotically.
messages: Expressed in ovaries. Not expressed in adult males.
messages: Interacts with orb, an RNA-binding protein, generating an ovarian cytoplasmic polyadenylation complex.
messages: Pronuclear migration does not occur in activated eggs. Defects in spindle structures (abnormally shaped spindles, spindle spurs, ectopic spindles associated with lost chromosomes and mispositioning of the meiosis II spindles) correlated with very high frequencies of chromosome non-disjunction and loss. The polar body nuclei do not associate with their normal monastral arrays of microtubules, the sperm aster is reduced in size, and the centrosomes often dissociate from a mitotic spindle that forms in association with the male pronucleus.

7227:Dmel CG10344
gene id: 7227:Dmel_CG10344
uniprot id: Q8MKK7
uniprot id: Q9W251
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG4672
gene id: 7227:Dmel_CG4672
uniprot id: M9PCT1
uniprot id: M9PFH8
uniprot id: M9PFR2
uniprot id: M9PFW5
uniprot id: M9PI80
uniprot id: Q9VV58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

7227:Dmel CG32444
gene id: 7227:Dmel_CG32444
uniprot id: Q9VP02
names: Similarity
messages: Belongs to the aldose epimerase family.

7227:Dmel CG15112
gene id: 7227:Dmel_CG15112
uniprot id: A0A0B4LFX0
uniprot id: Q8T4F7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Ena/VASP family.
messages: Expressed in axons of the embryonic nervous system.
messages: Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.
messages: Interacts with Abl and Src SH3 domains. Binds, in vitro and in vivo, the cytoplasmic domain of robo. Interacts with Zyx102EF and chic.
messages: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
messages: Tyrosine phosphorylated on multiple sites by Abl kinase. In vitro, phosphorylation on specific tyrosine residues inhibits interaction with Abl and Src SH3 domains.
messages: cytoskeleton
messages: lamellipodium

7227:Dmel CG4769
gene id: 7227:Dmel_CG4769
uniprot id: Q9VRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG8587
gene id: 7227:Dmel_CG8587
uniprot id: Q9V6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion membrane

7227:Dmel CG8104
gene id: 7227:Dmel_CG8104
uniprot id: A8JNQ0
uniprot id: A8JNQ1
uniprot id: B7Z0G0
uniprot id: Q9VT70
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: Chaperone protein with functions in nuclear localization (PubMed:26490864). Required for centrosome duplication and formation and function of the mitotic spindle (By similarity). In postmitotic neurons, acts with nudC downstream of dar1 to ensure correct positioning of the nuclei in primary dendrites and as a consequence, is required for determining multipolar neuron morphology (PubMed:26490864).
messages: RNAi-mediated knockdown results in multipolar Class I dendritic arborizing neurons forming a bipolar morphology (PubMed:26490864). Dendritic arborization is unaffected (PubMed:26490864).
messages: centrosome
messages: cytoskeleton
messages: spindle

7227:Dmel CG8594
gene id: 7227:Dmel_CG8594
uniprot id: Q7JZ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

7227:Dmel CG32819
gene id: 7227:Dmel_CG32819
uniprot id: Q8I044
uniprot id: Q8I0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7227:Dmel CG10064
gene id: 7227:Dmel_CG10064
uniprot id: Q9VS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: Cytoplasm
messages: flagellum

7227:Dmel CG5896
gene id: 7227:Dmel_CG5896
uniprot id: Q9VB68
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Endopeptidase (By similarity). Plays a key role in innate immunity by activating the Toll pathway in response to fungal and Gram-positive bacterial infections, presumably downstream of pattern-recognition receptors (PRR), such as PGRP-SA, GNBP1 and GNBP3, and upstream of spz processing enzyme SPE (PubMed:16631589, PubMed:18724373).
messages: Proteolytically cleaved by a tryspin-like protease which is likely to activate grass.
messages: Results in increased susceptibility to fungal or Gram-positive bacterial infection and failure to induce the expression of the Toll pathway-activated antifungal peptide Drs (PubMed:18724373). siRNA-mediated knockdown results in increased susceptibility to Gram-positive bacterial infection and severe reduction in the expression of the antifungal peptide Drs (PubMed:16631589). In a protease psh mutant background, complete loss of Drs induction and increased susceptibility to Gram-positive bacterial infection (PubMed:18724373).
messages: Secreted
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG9291
gene id: 7227:Dmel_CG9291
uniprot id: Q7JWD6
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG8064
gene id: 7227:Dmel_CG8064
uniprot id: Q9VE98
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG9280
gene id: 7227:Dmel_CG9280
uniprot id: P33438
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: About four tyrosines are sulfated.
messages: Extensively O-glycosylated and also N-glycosylated.
messages: In the N-terminal section; belongs to the type-B carboxylesterase/lipase family.
messages: Not known. Binds calcium ions.
messages: basement membrane

7227:Dmel CG34186
gene id: 7227:Dmel_CG34186
uniprot id: Q6IGE3
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

7227:Dmel CG7997
gene id: 7227:Dmel_CG7997
uniprot id: Q7K127
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

7227:Dmel CG14606
gene id: 7227:Dmel_CG14606
uniprot id: A0A1Z1CGZ4
uniprot id: Q9VI78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG33888
gene id: 7227:Dmel_CG33888
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG3416
gene id: 7227:Dmel_CG3416
uniprot id: A0A0B4KFH4
uniprot id: A0A0B4KGE6
uniprot id: P26270
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

7227:Dmel CG31950
gene id: 7227:Dmel_CG31950
uniprot id: Q8IPZ7
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

7227:Dmel CG31336
gene id: 7227:Dmel_CG31336
uniprot id: Q8IN23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily.
messages: Cell membrane
messages: In larvae, is expressed in neurons of the terminal external chemosensory organ and of the dorsal pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG14763
gene id: 7227:Dmel_CG14763
uniprot id: Q7K035
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7227:Dmel CG33820
gene id: 7227:Dmel_CG33820
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG33821
gene id: 7227:Dmel_CG33821
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG10050
gene id: 7227:Dmel_CG10050
uniprot id: Q9VI85
names: Domain
names: Function
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.
messages: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)).
messages: Contains 1 DXTW motif.

7227:Dmel CG30269
gene id: 7227:Dmel_CG30269
uniprot id: Q9W217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG5977
gene id: 7227:Dmel_CG5977
uniprot id: A0A0B4LHJ5
uniprot id: A0A126GV10
uniprot id: A0A126GV13
uniprot id: Q8I0P1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle (PubMed:15242610, PubMed:15562320, PubMed:15823537, PubMed:16276413, PubMed:17452528, PubMed:25875445, PubMed:18202664, PubMed:19341724). Regulates microtubule stability in the neuromuscular junction synapse (PubMed:15242610, PubMed:15562320, PubMed:19341724). Involved in lipid metabolism by regulating the size and distribution of lipid droplets (PubMed:25875445). Involved in axon regeneration by regulating microtubule severing (PubMed:23122959).
messages: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Chromosome
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed (PubMed:18202664). Interacts with microtubules (PubMed:15823537, PubMed:18202664). Interacts with atl; may be involved in microtubule dynamics (PubMed:19341724).
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules. Interacts with atl; may be involved in microtubule dynamics.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid droplet
messages: Loss of protein expression throughout the embryo leads to pupal lethality. Loss of protein expression specifically in the nervous system causes synaptic undergrowth and a reduction in total synaptic area. Neuromuscular junction boutons are smaller and more numerous. Microtubule stability appears to be enhanced within neuronal axons and at neuromuscular junctions and synaptic currents are increased. Older flies exhibit numerous vacuoles in the neuropil and cortex. Adult coordination and locomotory behavior are compromised and lifespan is reduced. RNAi-mediated knockdown results in climbing defects, which can be rescued following exposure to the drugs methylene blue, phenazine, or N-acetyl-L-cysteine (PubMed:26744324). RNAi-mediated knockdown results in increased oxidative stress, which can be rescued following exposure to the drug methylene blue (PubMed:26744324).
messages: Maternally expressed in early embryogenesis with high expression until blastoderm. At the cell formation stage, strongly expressed near the basal part of the cell layer underlying the surface. During germband extension and stomodeal plate formation, expressed in the ventral head and trunk ectoderm, as well as in cells near the cephalic furrow and in the invaginating hindgut and midgut primordia. After germband retraction and delamination of neuroblasts at stage 13, expressed in subsets of cells in all neuromeres of the CNS including those of the supraesophageal and subesophageal ganglia. In later embryonic stages expressed in cell clusters throughout the supraesophageal ganglion, with pronounced expression also seen in the subesophageal ganglion. In the ventral nerve cord (VNC), expressed in two broad longitudinal stripes located laterally, and weakly expressed in some midline cells. Also expressed in some sensory head organs of the peripheral nervous system (PNS), most probably the Bolwigs organs and/or the dorsal organs. Expressed in the developing larval neuromusculature, muscles and neuronal axons. Enriched in neuromuscular junctions throughout the muscles of the body wall. Enriched in punctate domains of synaptic boutons and excluded from interbouton axonal connections. Colocalizes with the synaptic vesicle pools.
messages: Membrane
messages: centrosome
messages: cytoskeleton

7227:Dmel CG30028
gene id: 7227:Dmel_CG30028
uniprot id: C0HKA2
uniprot id: C0HKA3
uniprot id: C0HKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG9339
gene id: 7227:Dmel_CG9339
uniprot id: M9PDI9
uniprot id: M9PDV9
uniprot id: Q0E8N9
uniprot id: Q9VIH6
uniprot id: Q9VIH7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected in the larval ventral nerve cord and neuromuscular junction boutons (at protein level).
messages: Endosome membrane
messages: GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking (PubMed:21458671, PubMed:25422373, PubMed:27669036). Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7 (PubMed:21458671, PubMed:25422373). This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads to increased neurotransmission and eventually neurodegeneration (PubMed:21458671, PubMed:25422373, PubMed:27669036). Preferentially binds phosphoinositides phosphorylated at the D5 position of the inositol ring, such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:27669036). Binding to phosphoinositides and thus membrane-association, is required for its function in regulating the turnover of synaptic-vesicle proteins (PubMed:27669036). It is therefore likely that it is recruited to vesicle membranes with high phosphoinositide content and thereby selectively prevents endolysosomal degradation of these vesicles (PubMed:27669036).
messages: Membrane
messages: The Rab-GAP TBC domain is essential for phosphoinositide binding.
messages: synaptic vesicle membrane

7227:Dmel CG32392
gene id: 7227:Dmel_CG32392
uniprot id: Q8T476
uniprot id: Q9VRY7
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

7227:Dmel CG3992
gene id: 7227:Dmel_CG3992
uniprot id: A0A0B4K6J1
uniprot id: A0A0B4KHL1
uniprot id: E2QCY6
uniprot id: P52172
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Initially observed in the analgen of the anterior and posterior midgut and the cephalic mesoderm. It is found in both the endodermal and mesodermal germ layers and for a brief period during gastrulation it is expressed in the amnioserosa. During germ band retraction it becomes restricted to the fat body.
messages: May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut.
messages: Nucleus

7227:Dmel CG13158
gene id: 7227:Dmel_CG13158
uniprot id: Q9V6A9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG44254
gene id: 7227:Dmel_CG44254
uniprot id: Q9I7H9
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TPA1 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Expressed at all developmental stages, with the highest levels at the first larval instar.
messages: In third-instar larval tissues,highly expressed in the fat body, with significant expression in other organs including the brain, salivary glands, imaginal disks and gut.
messages: Monomer.
messages: Nucleus
messages: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RpS23), thereby regulating protein translation termination efficiency.

7227:Dmel CG7275
gene id: 7227:Dmel_CG7275
uniprot id: Q9VUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

7227:Dmel CG13778
gene id: 7227:Dmel_CG13778
uniprot id: Q8SXU2
uniprot id: Q9VM47
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3971
gene id: 7227:Dmel_CG3971
uniprot id: Q9VV87
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:26214738). This process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle (PubMed:26214738). Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs (By similarity). Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree (By similarity). May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity).
messages: Detected in the CNS (central nervous system) of third larval instar (at protein level) (PubMed:17666430). Expressed in cyst progenitor cells (at protein level) (PubMed:17666430). In the adult fly, expressed in several tissues including, sperm, follicular epithelium, nurse cells and cyst cells (PubMed:17666430).
messages: During embryogenesis, expressed in early cellular blastoderm, involuting mesoderm, invaginating foregut, hindgut, in the CNS (central nervous system) and PNS (peripheral nervous system) during organogenesis, and imaginal disks (PubMed:17666430). In cyst cells, expression is restricted to post-meiotic stages during spermatid differentiation (PubMed:17666430).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: Probable cloning artifact.
messages: RNAi-mediated knockdown in larvae confers resistance to tunicamycin (PubMed:30081392). RNAi-mediated knockdown reduces ER stress response caused by the accumulation of unfolded protein in the ER by reducing Ire1 and PEK/PERK signaling (PubMed:30081392). RNAi-mediated knockdown in imaginal disks results in lethality (PubMed:17666430). RNAi-mediated knockdown in cyst cells results in abnormal sperm cell development with abnormal organization of individualization cones (PubMed:17666430).

7227:Dmel CG2110
gene id: 7227:Dmel_CG2110
uniprot id: H1UUE5
uniprot id: Q9V4T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG33649
gene id: 7227:Dmel_CG33649
uniprot id: N0ABE2
uniprot id: Q86BL4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7227:Dmel CG33122
gene id: 7227:Dmel_CG33122
uniprot id: Q8IQ05
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family. CTF18 subfamily.
messages: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA and has weak ATPase activity. The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.
messages: Component of the CTF18-RFC complex.
messages: Nucleus
messages: Viable (PubMed:11161570). In ovaries, results in defective oogenesis leading to sterility (PubMed:11161570). Results in morphological defects in both eye and wing (PubMed:11161570). Simultaneous knockout of cutlet and RfC4 or RfC38 exacerbates the eye defect of the single cutlet knockout (PubMed:11161570).

7227:Dmel CG10962
gene id: 7227:Dmel_CG10962
uniprot id: Q8IRN0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG7967
gene id: 7227:Dmel_CG7967
uniprot id: Q9W0B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

7227:Dmel CG10628
gene id: 7227:Dmel_CG10628
uniprot id: Q9I7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: May be involved in the ribosome maturation process.
messages: nucleolus

7227:Dmel CG17257
gene id: 7227:Dmel_CG17257
uniprot id: Q9VQK9
uniprot id: X2J6Q6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG11177
gene id: 7227:Dmel_CG11177
uniprot id: Q9VYB0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically, low level of expression in larvae. Expression in embryos is found within syncytial blastoderm, cellular blastoderm and gastrulation stages.
messages: Expressed in the developing salivary gland at late stages of embryogenesis. Also expressed in brain, neuroblast and wing disk.
messages: May be involved in a redox-related process. Required for survival and specifically for salivary gland morphogenesis.
messages: Secreted

7227:Dmel CG4866
gene id: 7227:Dmel_CG4866
uniprot id: Q7JZ53
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

7227:Dmel CG2137
gene id: 7227:Dmel_CG2137
uniprot id: A1Z707
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

7227:Dmel CG6974
gene id: 7227:Dmel_CG6974
uniprot id: Q9VFD6
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG32068
gene id: 7227:Dmel_CG32068
uniprot id: Q6AWN0
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Expressed at all developmental stages.
messages: Nucleus
messages: Viable and fertile. Females display reduced fecundity under restricted dietary conditions of 10% yeast. Fecundity can be rescued by supplementing their diet with methionine.

7227:Dmel CG15908
gene id: 7227:Dmel_CG15908
uniprot id: Q4QPU3
names: Similarity
messages: Belongs to the UPF0545 family.

7227:Dmel CG3760
gene id: 7227:Dmel_CG3760
uniprot id: A0A0B4LGI9
uniprot id: H0RNI8
uniprot id: H9XQA9
uniprot id: Q8MMC4
names: Similarity
messages: Belongs to the CDV3 family.

7227:Dmel CG6811
gene id: 7227:Dmel_CG6811
uniprot id: Q9VTU3
names: Disruption Phenotype
names: Function
messages: Defects during gastrulation.
messages: Functions as a GTPase-activating protein (GAP) for RhoA/Rho1 during gastrulation by converting it to an inactive GDP-bound state.

7227:Dmel CG11406
gene id: 7227:Dmel_CG11406
uniprot id: Q59E63
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG11516
gene id: 7227:Dmel_CG11516
uniprot id: P35832
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
messages: May play a key role in signal transduction and growth control. May have a role in the establishment of the intersegmental and segmental nerves.
messages: Membrane
messages: Selectively expressed in a subset of axons and pioneer neurons (including aCC and RP2) in the embryo.
messages: Start of expression coincides with the onset of axonogenesis.

7227:Dmel CG14173
gene id: 7227:Dmel_CG14173
uniprot id: C9QPG9
uniprot id: Q9VT50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

7227:Dmel CG17196
gene id: 7227:Dmel_CG17196
uniprot id: A0A0B4KH44
uniprot id: E1JIY0
uniprot id: Q9VBM6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG9554
gene id: 7227:Dmel_CG9554
uniprot id: M9ND38
uniprot id: Q05201
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Interacts with Dac and So.
messages: Nucleus
messages: Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity (PubMed:14628052, PubMed:14628053). The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development (PubMed:9428512, PubMed:9428513). Required for the survival of eye progenitor cells at a critical stage in morphogenesis (PubMed:8431945).

7227:Dmel CG13575
gene id: 7227:Dmel_CG13575
uniprot id: Q9W189
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG30503
gene id: 7227:Dmel_CG30503
uniprot id: Q7JX94
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5264
gene id: 7227:Dmel_CG5264
uniprot id: Q9VCY0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5057
gene id: 7227:Dmel_CG5057
uniprot id: M9PFU7
uniprot id: Q9GYU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex (By similarity). Interacts with MED4 and MED21.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7227:Dmel CG33057
gene id: 7227:Dmel_CG33057
uniprot id: Q86BH3
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

7227:Dmel CG2194
gene id: 7227:Dmel_CG2194
uniprot id: Q9W374
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

7227:Dmel CG5277
gene id: 7227:Dmel_CG5277
uniprot id: O76994
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

7227:Dmel CG2679
gene id: 7227:Dmel_CG2679
uniprot id: Q06003
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Embryonic visceral mesoderm and primordia of somatic musculature.
messages: Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway (PubMed:23353890). May play an indirect role in regulation of gene expression during embryonic mesoderm formation (PubMed:8462875).
messages: Endosome membrane
messages: Flies are viable and fertile.

7227:Dmel CG4999
gene id: 7227:Dmel_CG4999
uniprot id: Q9V3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG3344
gene id: 7227:Dmel_CG3344
uniprot id: Q9W0N8
names: Similarity
messages: Belongs to the peptidase S10 family.

7227:Dmel CG14550
gene id: 7227:Dmel_CG14550
uniprot id: Q8MSE4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8837
gene id: 7227:Dmel_CG8837
uniprot id: Q9VQN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG17075
gene id: 7227:Dmel_CG17075
uniprot id: Q9VPM2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7036
gene id: 7227:Dmel_CG7036
uniprot id: Q7YZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JADE family.
messages: May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development.
messages: Nucleus

7227:Dmel CG5378
gene id: 7227:Dmel_CG5378
uniprot id: Q9V3G7
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S10 family.

7227:Dmel CG33546
gene id: 7227:Dmel_CG33546
uniprot id: Q8INS9
names: Similarity
messages: Belongs to the GST superfamily.

7227:Dmel CG6394
gene id: 7227:Dmel_CG6394
uniprot id: Q8MV48
uniprot id: X2JEA3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Expressed both maternally and zygotically. Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development.
messages: Expressed in developing oocytes and egg chambers. During embryonic stages 9-11, expressed in the primordium of the foregut, midgut and hindgut. Expressed in the salivary glands from embryonic stage 12 onwards. During embryonic stages 12-13, expressed in the posterior midgut and hindgut. During embryonic stages 14-15, expression continues in the hindgut. During embryonic stages 16-17, expressed in the antennomaxillary complex. In third instar larvae, ubiquitously expressed in wing, with increased expression in the notum and ventral wing pouch, eye-antennal, leg and haltere imaginal disks.
messages: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (PubMed:11925450, PubMed:12829714). In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:11925450). Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:11925450). Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure (PubMed:20807760).
messages: Golgi apparatus membrane
messages: Membrane
messages: RNAi-mediated knockdown in the whole body or respiratory system during development is lethal (PubMed:22157008). RNAi-mediated knockdown in hemocytes, amnioserosa, mesoderm or digestive system and reproductive tract causes no defect (PubMed:22157008).
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG7092
gene id: 7227:Dmel_CG7092
uniprot id: Q9VWZ3
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG3021
gene id: 7227:Dmel_CG3021
uniprot id: Q9W5B6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion

7227:Dmel CG2493
gene id: 7227:Dmel_CG2493
uniprot id: Q9VIM0
names: Similarity
messages: Belongs to the peptidase S28 family.

7227:Dmel CG15106
gene id: 7227:Dmel_CG15106
uniprot id: Q7K1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Catalyzes juvenile hormone hydrolysis.
messages: Endoplasmic reticulum membrane

7227:Dmel CG31991
gene id: 7227:Dmel_CG31991
uniprot id: Q960U8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

7227:Dmel CG11624
gene id: 7227:Dmel_CG11624
uniprot id: P0CG69
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.
messages: Nucleus
messages: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

7227:Dmel CG10847
gene id: 7227:Dmel_CG10847
uniprot id: Q8MSX1
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in all germline cells of the germarium including the stem cells and dividing cystocytes.
messages: In the germarium, it begins to accumulate preferentially within the future oocyte shortly after formation of the 16-cell cyst. In midoogenesis, it can be seen transiently at the posterior edge of the oocyte, but by stage 9 assumes an anterior localization, and appears to be more concentrated at the dorsal side of the oocyte, above the oocyte nucleus. This pattern of localization is similar to that seen for grk mRNA and protein, though not tightly restricted to the dorsal side.
messages: Interacts with hfp; however, given the nuclear localization of hfp, the relevance of such interaction is unclear. Interacts with CycE, Cul1, and the SCF-proteasome complex.
messages: It is uncertain whether Met-1 or Met-143 is the initiator.
messages: Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.
messages: Splicing donor and acceptor sites between exon 10 and exon 11 are not canonical.

7227:Dmel CG1716
gene id: 7227:Dmel_CG1716
uniprot id: E1JJN9
uniprot id: Q9VYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Nucleus
messages: Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).

7227:Dmel CG33214
gene id: 7227:Dmel_CG33214
uniprot id: M9PIG4
uniprot id: Q9VP27
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7678
gene id: 7227:Dmel_CG7678
uniprot id: Q9VE77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7227:Dmel CG7098
gene id: 7227:Dmel_CG7098
uniprot id: M9PHZ1
uniprot id: Q9VWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

7227:Dmel CG9648
gene id: 7227:Dmel_CG9648
uniprot id: M9NDC9
uniprot id: P91664
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAX family.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD.
messages: Embryo, especially in central nervous system.
messages: Highest expression in embryos.
messages: Intron retention.
messages: Nucleus
messages: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor.

7227:Dmel CG4976
gene id: 7227:Dmel_CG4976
uniprot id: Q8MT36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Nucleus
messages: Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).

7227:Dmel CG14439
gene id: 7227:Dmel_CG14439
uniprot id: Q9W3W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

7227:Dmel CG14296
gene id: 7227:Dmel_CG14296
uniprot id: B5RIU6
uniprot id: Q8T390
names: Disruption Phenotype
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Dramatic impairment of clathrin-mediated endocytosis, severe defects in motility and death at the early L2 larval stage.
messages: Expression is abundant in central nervous system (brain lobes and the ventral nerve cord) starting at embryonic stage 13 through to third instar larvae. Also expressed in photoreceptors in the eye imaginal disks and the Bolwig organs of the peripheral nervous system.
messages: Membrane
messages: Partially edited. Target of Adar.
messages: Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.

7227:Dmel CG6850
gene id: 7227:Dmel_CG6850
uniprot id: Q09332
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Expressed in salivary glands (at protein level) (PubMed:11535823). Is present at low but detectable levels in the earliest embryos, increasing at 6-8 hours with a maximum at 10-12 hours (PubMed:7729408). Levels decrease thereafter and are not detected in 18-20 hours embryos and first instar larvae but is detected again at second instar to pupation (PubMed:7729408).
messages: Monomer (PubMed:28490633). May interact with CG7484/Sep15 (Probable).
messages: Recognizes glycoproteins with minor folding defects (PubMed:22960071). Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum (PubMed:22960071). Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (PubMed:11535823).

7227:Dmel CG14077
gene id: 7227:Dmel_CG14077
uniprot id: Q9VVU8
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

7227:Dmel CG7445
gene id: 7227:Dmel_CG7445
uniprot id: P35554
names: Developmental Stage
names: Function
names: PTM
names: Tissue Specificity
messages: Expressed in late pupal and adult stages.
messages: Found only in indirect flight muscles (IFM).
messages: Possibly involved in the regulation of flight muscles contraction, possibly by modulating actin-myosin interaction.
messages: Several forms of flightin are thought to be produced through post-translational modifications, possibly by phosphorylation.

7227:Dmel CG14076
gene id: 7227:Dmel_CG14076
uniprot id: Q9VVU7
names: Similarity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

7227:Dmel CG7228
gene id: 7227:Dmel_CG7228
uniprot id: B7Z031
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Plays a role in mycobacterial infection. Mediates infection by M.fortuitum and uptake of M.smegmatis.
messages: (Microbial infection) RNAi-mediated knockdown blocks infection by M.fortuitum and uptake of M.smegmatis.
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Detected in all examined tissues of L3 instar larvae. Expression in the ring gland and anterior spiracles increases during development. In the ovaries it is predominantly expressed in one pole, and in the anterior spiracles it is mostly expressed in the spiracular gland. Ubiquitously expressed throughout the testis and alimentary tract.
messages: The name 'peste' means plague in Latin and derives from its role in bacterial infection.

7227:Dmel CG33102
gene id: 7227:Dmel_CG33102
uniprot id: Q9NFT9
names: Function
names: Similarity
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.

7227:Dmel CG17035
gene id: 7227:Dmel_CG17035
uniprot id: Q9VUV6
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG4032
gene id: 7227:Dmel_CG4032
uniprot id: P00522
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
messages: Arm and ena colocalize with Abl at adherens junctions throughout development.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
messages: Both loss- and gain-of-function mutants exhibit neurons within the pCC/MP2 pathway that incorrectly project across the midline. Loss of Abl disrupts cell migration and cell shape changes during dorsal closure.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.

7227:Dmel CG8068
gene id: 7227:Dmel_CG8068
uniprot id: A0A0B4JCQ7
uniprot id: A0A0B4JD03
uniprot id: A0A0B4JD33
uniprot id: A0A0B4K6T9
uniprot id: A0A0B4LEH9
uniprot id: A1Z7P5
uniprot id: A1Z7P7
uniprot id: A1Z7P8
uniprot id: A1Z7P9
uniprot id: A1Z7Q1
uniprot id: Q5BIG7
uniprot id: Q7KNF5
uniprot id: Q8IGK3
uniprot id: Q9XYM5
names: Similarity
messages: Belongs to the PIAS family.

7227:Dmel CG2781
gene id: 7227:Dmel_CG2781
uniprot id: Q9VHX7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.
messages: Membrane
messages: RNAi-mediated knockdown leads to lethality before eclosion (PubMed:29739804). RNAi-mediated knockdown in neurons leads to neurodegeneration in the central nervous system including degeneration of retina, defects in the fenestrated basement membrane and ommatidial disarray (PubMed:29739804). Effects are probably due to altered levels of very-long chain fatty acids (VLCFAs) (PubMed:29739804). In contrast, glial-specific RNAi-mediated knockdown results in no defect (PubMed:29739804).

7227:Dmel CG43224
gene id: 7227:Dmel_CG43224
uniprot id: A0A0B4K6A2
uniprot id: A0A0B4K6R0
uniprot id: A0A0B4K785
uniprot id: A0A0B4K7J4
uniprot id: A0A0B4KH06
uniprot id: A0A0B4LIE3
uniprot id: Q59DV8
uniprot id: Q8IH40
names: Similarity
messages: Belongs to the GDNFR family.

7227:Dmel CG12526
gene id: 7227:Dmel_CG12526
uniprot id: E5AJN4
uniprot id: Q9VT08
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to benzaldehyde and acetophenone.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG11876
gene id: 7227:Dmel_CG11876
uniprot id: Q7K5K3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in salivary glands (at protein level).
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown in neurons reduces life span of adult flies and results in locomotor defects at both larval and adult stages accompanied by abnormal morphology of motor neuron terminals at neuromuscular junctions and mitochondrial fragmentation in brains (PubMed:29501567). RNAi-mediated knockdown in eye disks induces morphologically aberrant rough eye phenotype in adults and aberrant photoreceptor axon targeting (PubMed:29501567).
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity). Might play a role in regulating synapse structure formation at neuromuscular junctions (PubMed:29501567). Might play a role in maintenance of mitochondrial morphology (PubMed:29501567).

7227:Dmel CG17270
gene id: 7227:Dmel_CG17270
uniprot id: Q9VDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG9868
gene id: 7227:Dmel_CG9868
uniprot id: Q9W1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG4545
gene id: 7227:Dmel_CG4545
uniprot id: A0A0B4LHJ6
uniprot id: P51905
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Cell membrane
messages: Expression is specific to cell bodies in the ventral ganglion of the embryonic and larval nervous system.
messages: Membrane
messages: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.
messages: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

7227:Dmel CG10478
gene id: 7227:Dmel_CG10478
uniprot id: Q9VRS0
names: Similarity
messages: Belongs to the importin alpha family.
messages: Belongs to the proteasome subunit S5B/HSM3 family.

7227:Dmel CG6073
gene id: 7227:Dmel_CG6073
uniprot id: A0A0B4K7K6
uniprot id: Q9VBG6
names: Similarity
messages: Belongs to the HGH1 family.

7227:Dmel CG6913
gene id: 7227:Dmel_CG6913
uniprot id: Q9VGJ5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: First detected in 6 to 9 hour old embryos. Expression is highest in 9 to 15 hour old embryos. First detected in stage 11 embryos within the neurogenic region. Detected in the procephalic region, the ventral nerve cord, subesophagal, thoracic and abdominal ganglia in stage 13 to 14 embryos. Detected in embryonic midgut primordia. Barely detectable at the first stage of larval development. Not detectable in older larvae, pupae or adults.
messages: Nucleus
messages: Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).

7227:Dmel CG12428
gene id: 7227:Dmel_CG12428
uniprot id: Q9VB02
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7227:Dmel CG5287
gene id: 7227:Dmel_CG5287
uniprot id: Q9VK30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG17600
gene id: 7227:Dmel_CG17600
uniprot id: M9PJS6
uniprot id: Q9VR60
names: Similarity
messages: Belongs to the MS4A family.

7227:Dmel CG4452
gene id: 7227:Dmel_CG4452
uniprot id: M9PEW8
uniprot id: Q9VSW7
names: Similarity
messages: Belongs to the FAM76 family.

7227:Dmel CG10106
gene id: 7227:Dmel_CG10106
uniprot id: Q7KJ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG11498
gene id: 7227:Dmel_CG11498
uniprot id: A0A1Z1CH18
uniprot id: Q9VAA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG32356
gene id: 7227:Dmel_CG32356
uniprot id: Q7KUB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG5976
gene id: 7227:Dmel_CG5976
uniprot id: Q7KTY3
uniprot id: Q86PD7
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

7227:Dmel CG8636
gene id: 7227:Dmel_CG8636
uniprot id: Q9W4X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

7227:Dmel CG8851
gene id: 7227:Dmel_CG8851
uniprot id: Q9VQS1
uniprot id: R9PY49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

7227:Dmel CG12066
gene id: 7227:Dmel_CG12066
uniprot id: P16911
names: Developmental Stage
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: In embryos, pupae and adults.
messages: More abundant in adult body than adult head.

7227:Dmel CG4405
gene id: 7227:Dmel_CG4405
uniprot id: Q7JV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG32592
gene id: 7227:Dmel_CG32592
uniprot id: Q9NB71
uniprot id: X2JF19
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ) together with Rae1 and Fsn (PubMed:10839352, PubMed:21874015, PubMed:17697379).
messages: Belongs to the RING-Cys relay (RCR) family.
messages: Component of an E3 ubiquitin ligase complex composed of hiw, Rae1 and Fsn (PubMed:17697379, PubMed:21874015). Interacts with Rae1; the interaction with Rae1 may protect hiw from autophagy-mediated degradation (PubMed:21874015).
messages: Express throughout the nervous system (PubMed:10839352, PubMed:21874015). Stage 13 embryos show expression in the central nervous system (CNS) at the longitudinal axon tracts around which the synaptic neuropil forms (PubMed:10839352). Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone (PubMed:10839352). Expression at neuromuscular junctions (NMJ) and in the CNS is also seen in third instar larvae (at protein level) (PubMed:10839352).
messages: Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches.
messages: Synapse
messages: The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
messages: The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.
messages: axon

7227:Dmel CG4620
gene id: 7227:Dmel_CG4620
uniprot id: A0A0B4K6Y4
uniprot id: A0A0B4K7D1
uniprot id: A0A0B4KGS7
uniprot id: A0A126GV12
uniprot id: Q86B79
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the unkempt family.
messages: Cytoplasm
messages: Essential for late larval/early pupal development.
messages: Expressed both maternally and zygotically.
messages: Flies exhibit an 'unkempt' appearance: small rough eyes, held out wings and crossed scutellar bristles.
messages: Ubiquitous in most somatic tissues from syncytial embryo through to embryo stage 15. Expression becomes restricted predominantly to the CNS at stages 16 and 17.

7227:Dmel CG42340
gene id: 7227:Dmel_CG42340
uniprot id: B7Z0W7
uniprot id: R9PY17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG8440
gene id: 7227:Dmel_CG8440
uniprot id: A0A0B4K812
uniprot id: Q7KNS3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Expressed both maternally and zygotically. Expressed throughout all developmental stages but is most abundant at precellular blastoderm stages; expression declines after gastrulation. Expressed at higher level in adult females. Following germ-band retraction it is enriched in the developing central nervous system. In third-instar larvae, low levels are detected in the brain hemispheres and imaginal disks.
messages: Expressed primarily in germline cells during oogenesis. Low levels are detected in the germarium in regions 1 and 2 and in both nurse cells and the oocyte in stage 2-4 egg chambers. Enriched in the oocyte during stages 5-7 and in nurse cells in stage 8-10 egg chambers. Ubiquitously distributed in early embryos. Expressed throughout cell bodies, dendrites and axons of the mushroom-body neurons.
messages: Interacts with dynein and dynactin. Does not interact with Paf-A-Halpha.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, branching and maturation and axonal transport. Required for synchronized cell divisions in the germline, fusome integrity and oocyte differentiation. Acts together with BicD, Egl, dynein and microtubules to determine oocyte identity during oogenesis. Also required for nurse cell to oocyte transport during oocyte growth and for the positioning of the nucleus in the oocyte.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle pole

7227:Dmel CG9054
gene id: 7227:Dmel_CG9054
uniprot id: Q9VNV3
names: Developmental Stage
names: Function
names: Similarity
messages: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity (By similarity).
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Expressed both maternally and zygotically throughout development. Expression is highest in early embryos.

7227:Dmel CG43366
gene id: 7227:Dmel_CG43366
uniprot id: A1Z6I3
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG10160
gene id: 7227:Dmel_CG10160
uniprot id: B5RJQ0
uniprot id: Q95028
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.

7227:Dmel CG3226
gene id: 7227:Dmel_CG3226
uniprot id: Q9W3Y3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

7227:Dmel CG10488
gene id: 7227:Dmel_CG10488
uniprot id: Q9VTX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG17461
gene id: 7227:Dmel_CG17461
uniprot id: Q9V4A1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG17575
gene id: 7227:Dmel_CG17575
uniprot id: A0A0B4JCT2
uniprot id: A1Z957
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG11576
gene id: 7227:Dmel_CG11576
uniprot id: Q9V9S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

7227:Dmel CG17273
gene id: 7227:Dmel_CG17273
uniprot id: Q9Y0Y2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mutant flies show life span extension and increased activity. Heterozygous mutants show increased ratios of AMP:ATP (3 to 4-fold) and ADP:ATP (2-fold), also observed in response to caloric restriction, and associated with life span extension phenotypes in yeast and worms.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span.

7227:Dmel CG8770
gene id: 7227:Dmel_CG8770
uniprot id: P29829
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: In the Drosophila compound eye.

7227:Dmel CG5358
gene id: 7227:Dmel_CG5358
uniprot id: Q9VH48
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Expression is high in early embryos, reduced in late embryonic and larval stages, up-regulated at the early prepupal stage and then reduced until the adult stage where it is again up-regulated.
messages: Homodimer (By similarity). Interacts with EcR.
messages: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling. Coordinates ecdysone-mediated expression of cell death genes.
messages: Nucleus
messages: Present ubiquitously (at protein level). Expressed in the imaginal disks and in larval brains, and to a much lesser degree in the polytene larval tissue such as salivary glands.
messages: The dimethylated protein is the major form.

7227:Dmel CG33905
gene id: 7227:Dmel_CG33905
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG6213
gene id: 7227:Dmel_CG6213
uniprot id: A0A0B4LHE7
uniprot id: Q9XZH6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: RNAi-mediated knockdown specifically in pHCl-2 expressing enterocytes delays pupariation and reduces food intake. However, knockdown in other enterocytes has no effect on developmental timing.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7227:Dmel CG30010
gene id: 7227:Dmel_CG30010
uniprot id: A0A0B4KFH5
uniprot id: Q8MKL1
names: Similarity
messages: Belongs to the UPF0598 family.

7227:Dmel CG13564
gene id: 7227:Dmel_CG13564
uniprot id: Q9W1B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG9765
gene id: 7227:Dmel_CG9765
uniprot id: A0A0B4JCV4
uniprot id: A0A0B4JD97
uniprot id: A0A0B4K6I7
uniprot id: A0A0B4KFK1
uniprot id: Q86BB4
uniprot id: Q86BB5
uniprot id: Q8IPN1
uniprot id: Q95TU9
uniprot id: Q9VN51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

7227:Dmel CG9166
gene id: 7227:Dmel_CG9166
uniprot id: Q9W0F9
names: Similarity
messages: Belongs to the Iojap/RsfS family.

7227:Dmel CG1349
gene id: 7227:Dmel_CG1349
uniprot id: Q9VA37
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Detected during embryogenesis (at protein level) (PubMed:16139213). Maternally contributed, after which its levels fall slightly in embryo but increase again through development and in adult (PubMed:16139214, PubMed:16203113).
messages: Expressed in the head and testis (at protein level) (PubMed:16139213). Ubiquitously expressed at constant levels (PubMed:16139214).
messages: Mitochondrion
messages: Nucleus
messages: Oxidation of Cys-45 and Cys-104 in response to oxidative stress (PubMed:16894167, PubMed:22515803). Levels of oxidation increase with age (PubMed:16894167).
messages: Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251).
messages: Viable and fertile (PubMed:16203113). Larvae develop normally but show increased oxidative stress-induced cell death (PubMed:23593018, PubMed:30540251). Larvae show structurally normal neuromuscular junctions, however they fail to show structural synaptic plasticity in response to oxygen species (ROS) levels (PubMed:30540251). Adult flies show severe defects in locomotor ability without loss of dopaminergic neurons and increased sensitivity to oxidative stress (PubMed:16139214, PubMed:16203113, PubMed:23593018). Results in altered subcellular localization of Daxx (PubMed:23593018). Does not show more elevated levels of methylglyoxal adducts than controls (PubMed:27903648). Double knockouts for dj-1beta and dj-1alpha is viable but with reduced male fertility (PubMed:16139213, PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha is more sensitive to chemical agents that induce oxidative stress (PubMed:16139213). Double knockouts for dj-1beta and dj-1alpha shows reduced lifespan and decreased spontaneous movement over time (PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha spermatozoa are morphologically normal but immotile with abnormal vacuoles in the Nebenkern, abnormal mitochondria and aberrant separation of investment cones during sperm individualization (PubMed:20457924). Double knockouts for DJ-1beta and Daxx restore normal number of dopaminergic neurons, locomotor activity and sensitivity to oxidative stress and UV-induced damage (PubMed:23593018).

7227:Dmel CG42856
gene id: 7227:Dmel_CG42856
uniprot id: A0A0B4LFW1
uniprot id: A1ZBC4
uniprot id: A8DYI4
uniprot id: A8DYI5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

7227:Dmel CG14993
gene id: 7227:Dmel_CG14993
uniprot id: Q9VZI8
names: Similarity
messages: Belongs to the FAH family.

7227:Dmel CG10353
gene id: 7227:Dmel_CG10353
uniprot id: M9PGX9
uniprot id: M9PJJ8
uniprot id: Q76NS2
uniprot id: Q9VYS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG9354
gene id: 7227:Dmel_CG9354
uniprot id: Q9VHE5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

7227:Dmel CG11835
gene id: 7227:Dmel_CG11835
uniprot id: Q9VPR2
names: Similarity
messages: Belongs to the NAC-beta family.

7227:Dmel CG43154
gene id: 7227:Dmel_CG43154
uniprot id: Q8SY41
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BCAS3 family.
messages: Cytoplasm
messages: Expressed in all postembryonic pericardial cells, but not in cardioblasts. Also expressed in Garland cells in third instar larvae (at protein level).
messages: Has been proposed to contain 7 WD repeats. This prediction could not be reproduced.
messages: Not expressed during embryonic development and first instar larvae. Expression detected from second instar larval stage into adulthood (at protein level).
messages: RNAi-mediated knockdown of the protein in the hematopoietic system and pericardial cells causes a decrease in macropinocytic uptake by pericardial cells.
messages: Regulates macropinocytosis in pericardial cells.

7227:Dmel CG11181
gene id: 7227:Dmel_CG11181
uniprot id: Q9VMA3
uniprot id: X2J9P9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos (PubMed:9118812). Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation (PubMed:21937713). Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G (PubMed:14685270, PubMed:15465908, PubMed:21081899). This may contribute to translational repression but does not appear to be necessary for it to occur (PubMed:21081899). Can promote translational repression independently of deadenylation and eIF4E1 binding (PubMed:21937713). Required for correct localization of eIF4E1 in the developing oocyte (PubMed:15465908). Required for translational repression of oskar (osk) mRNA (PubMed:14691132, PubMed:14723848). Also required for the translational repression of nanos (nos) mRNA (PubMed:21081899). Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development (PubMed:22454519, PubMed:17277377). Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte (PubMed:22164257). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934).
messages: Belongs to the 4E-T/EIF4E-T family.
messages: Component of the osk RNP complex, which is composed of at least exu, yps, aret/bruno, cup, and the mRNA of osk (PubMed:10662770). Interacts with the decapping activators me31B and tral (PubMed:21937713). Component of the nos RNP complex, which is composed of at least smg, cup, tral, me31B, the CCR4-NOT complex members Rga/NOT2 and Caf1, and the mRNA of nos (PubMed:21081899). Interacts with btz (PubMed:14691132, PubMed:14723848). Recruited to the 3'-UTR of nos and osk mRNAs by smg and btz, respectively (PubMed:14685270, PubMed:14691132). Forms a ribonucleoprotein complex (RNP) containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934). No interaction was detected with pAbp in 1-5 hour embryos (PubMed:28875934). Interacts with osk and vas (PubMed:22454519). Interacts with Pop2, twin/CCR4, Rga, Not3 and Not1 which are all core components of the CCR4-NOT deadenylase complex; interaction with the complex is required for cup deadenylation activity (PubMed:21937713). Interacts with nos (PubMed:11060247). Interacts with smg (PubMed:14685270). Interacts (via YXXXXLphi motifs) with eIF4E1; the interaction promotes retention of cup in the cytoplasm (PubMed:14723848, PubMed:14685270, PubMed:15465908, PubMed:21937713, PubMed:22832024). Interacts with orb; the interaction represses the orb positive autoregulatory loop (PubMed:22164257). Interacts with Nup154 (PubMed:17277377).
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Expressed in the egg chamber and more specifically in nurse cells (at protein level) (PubMed:17277377). Expressed during the first 2 hours of embryogenesis but is absent in 2-5 hour embryos (at protein level) (PubMed:28875934). Expressed both maternally and zygotically (PubMed:9118812). Expressed throughout embryogenesis (PubMed:22454519). In stage 2, uniformly distributed throughout the whole embryo (PubMed:22454519). During blastoderm formation, concentrated at the posterior pole to become incorporated into newly formed germ cells (PubMed:22454519). Subsequently accumulates specifically in the pole cells at stage 10, when they migrate through the posterior midgut primordium, and during stage 14, when the germ cells reach their final destination (PubMed:22454519).
messages: Mislocalization and precocious expression of orb in the ovary, accumulation of high levels of orb in nurse cells, elongation of orb poly-A tails, hyperphosphorylation of orb and reduced osk mRNA levels (PubMed:22164257). Reduced number of germ cells (PubMed:22454519).
messages: Nucleus
messages: Predominantly expressed in ovaries and in 0-2 hours old embryos. Weakly expressed in testis. Expressed in young embryos through stage 9, then it decreases throughout the rest of embryogenesis. In ovaries, it is expressed in germ cells throughout pre-vitellogenic development, but is not expressed in the somatic follicle cells. In germarial cysts, the protein (and not the transcripts) is transported selectively into the oocyte.
messages: The YXXXXLphi motifs mediate interaction with eIF4E1.

7227:Dmel CG7107
gene id: 7227:Dmel_CG7107
uniprot id: B9EQV5
uniprot id: E1JJP0
uniprot id: E6PBY8
uniprot id: M9NH07
uniprot id: M9PHJ0
uniprot id: M9PHR2
uniprot id: M9PJM6
uniprot id: P19351
uniprot id: X2JBP9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Tissue Specificity
messages: Belongs to the troponin T family.
messages: Flies exhibit 3 distinct syndromes of myofibrillar abnormalities; elimination of thin filaments except where they are bound by electron-dense material presumed to be Z-disk proteins, degeneration of muscles and reduction in the diameter of the myofibril lattice.
messages: Intron retention.
messages: Isoform 2 is expressed only in larvae.
messages: Isoform 3 is expressed in the hypoderm. Isoform 8 is expressed in the dorsal vessel. Isoform 6 is expressed in adult TDT muscle and isoform 9 in adult IFM, flight and jump muscles.
messages: Some glutamate residues are polyglycylated by TTLL3B. This modification occurs exclusively on glutamate residues and results in polyglycine chains on the gamma-carboxyl group.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

7227:Dmel CG18041
gene id: 7227:Dmel_CG18041
uniprot id: A0A0B4KHH6
uniprot id: A0A0B4LHU7
uniprot id: Q9VAF4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

7227:Dmel CG6708
gene id: 7227:Dmel_CG6708
uniprot id: Q9VC05
names: Similarity
messages: Belongs to the OSBP family.

7227:Dmel CG15479
gene id: 7227:Dmel_CG15479
uniprot id: Q9VK13
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Embryonic lethality with increased frequency of embryonic head defects and reduced embryonic cell death.
messages: Expressed throughout the embryo at stage 11 with a higher level in the anterior region. At stage 12, a few cells show expression.
messages: Plays a role in inducing apoptosis and is involved in the repair of head patterning defects in the embryo caused by extra maternal copies of the homeotic gene bicoid.

7227:Dmel CG13441
gene id: 7227:Dmel_CG13441
uniprot id: Q9V969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr57a subfamily.
messages: Cell membrane
messages: In larvae, is expressed in neurons of the terminal external chemosensory organ as well as in the dorsal pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG2275
gene id: 7227:Dmel_CG2275
uniprot id: A0A0B4KEI6
uniprot id: P18289
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. Jun subfamily.
messages: Death in mid to late embryogenesis with large anterior and dorsal holes.
messages: During embryogenesis, expression is elevated in the amnioserosa, in the cells of the dorsolateral epidermis during and following germ-band retraction, in the cells at the leading dorsal edge of the epidermis and in the cells along the cephalic furrow (at protein level).
messages: Expressed during embryonic development.
messages: Heterodimer with kay/Fra (PubMed:1696724, PubMed:2116361). The kay-Jra complex is bound more stably to the AP-1 site than either of the two proteins alone (PubMed:2116361). Interacts with Atf3; the interaction enhances the DNA-binding activity of Atf3 (PubMed:20023169).
messages: Nucleus
messages: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723).

7227:Dmel CG33901
gene id: 7227:Dmel_CG33901
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG8648
gene id: 7227:Dmel_CG8648
uniprot id: Q7K7A9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

7227:Dmel CG8481
gene id: 7227:Dmel_CG8481
uniprot id: Q59DX8
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family.
messages: N-alpha-acetyltransferase that acetylates the amino terminal acidic residue of proteins devoid of initiator methionine (PubMed:29581307). Preferentially acts on proteins starting with Asp-Asp-Asp and Glu-Glu-Glu sequences (PubMed:29581307). In vitro, shows high activity towards N-terminal sequences starting with Met-Asp-Glu-Leu, Met-Glu-Glu-Glu and Met-Asp-Asp-Asp (PubMed:29581307).

7227:Dmel CG7008
gene id: 7227:Dmel_CG7008
uniprot id: Q9W0S7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with the RNA-induced silencing complex (RISC) (PubMed:14508492). Interacts with the RISC components AGO2, Fmr1 and vig (PubMed:14508492). Interacts with piwi (PubMed:26808625).
messages: Cytoplasm
messages: Endonuclease which shows activity towards both DNA and RNA substrates (PubMed:14508492, PubMed:26808625). Has a role in translation regulation throught its association with the with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:26808625). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline (PubMed:26808625). Together with piwi, might be involved in transposon repression in the germline (PubMed:26808625).
messages: Expressed in adult ovaries and testis (at protein level).
messages: Expressed in both germline and somatic cells during oogenesis and spermatogenesis (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown results in defective spermatogenesis.
messages: Tudor domain specifically binds peptides with symmetrically dimethylated arginines (sDMA) and may facilitate protein-protein interactions.

7227:Dmel CG5799
gene id: 7227:Dmel_CG5799
uniprot id: Q8MLT6
uniprot id: Q9W268
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10449
gene id: 7227:Dmel_CG10449
uniprot id: Q2EJP5
uniprot id: Q9V3A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Membrane
messages: Negatively regulates tyrosine hydroxylase activity.

7227:Dmel CG7461
gene id: 7227:Dmel_CG7461
uniprot id: A1ZBJ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7227:Dmel CG17374
gene id: 7227:Dmel_CG17374
uniprot id: Q7PLB8
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

7227:Dmel CG4706
gene id: 7227:Dmel_CG4706
uniprot id: Q8T4D6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

7227:Dmel CG3934
gene id: 7227:Dmel_CG3934
uniprot id: Q9VH31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

7227:Dmel CG30273
gene id: 7227:Dmel_CG30273
uniprot id: Q8MME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7227:Dmel CG5826
gene id: 7227:Dmel_CG5826
uniprot id: Q9VEJ0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Expressed in thoracic flight muscles (at protein level).
messages: High expression in embryos and adult tissues, lower expression in larval and pupal stages (PubMed:11677042). Expression levels decrease in an age-dependent manner, levels are 75% less on day 30 than on day 5 post eclosion (PubMed:23124252).
messages: Homodimer; disulfide-linked, upon oxidation (By similarity). 6 homodimers assemble to form a ring-like dodecamer (By similarity).
messages: Mitochondrion
messages: RNAi-mediated knockdown leads to decreased lifespan, increased susceptibility to oxidative stress and an increase in apoptotic cells in the central brain (PubMed:33889951, PubMed:20869434, PubMed:23124252). Exposure of young (10-15 days old) flies to paraquat or hydrogen peroxide leads to decreased resistance to oxidants (PubMed:20869434). Reduced survival rate under oxidative stress conditions; further decrease in responsiveness to oxidative stress with age (PubMed:23124252). Affects coordinated motor behavior, such as shorter distance covered in a given time interval (15% reduction) and reduced velocity (16% reduction) compared to wild-type animals (PubMed:33889951). RNAi-mediated knockdown in neurons and glia, but not in muscles, significantly affects motor behavior (PubMed:33889951). Pan-neuronal RNAi-mediated knockdown reduces distance covered over time by 14%, with velocity during periods of moving being reduced by 13% compared to control animals (PubMed:33889951). Pan-glial RNAi-mediated knockdown reduces the distance covered by 7% and velocity during periods of moving by 8% (PubMed:33889951). RNAi-mediated knockdown in a Prx5 null mutant background leads to mean life span reduction from 55-70 days to 12.8 days and, after appearing relatively normal for the first 9-11 days after eclosion, animals undergo a very rapid increase in mortality rate (PubMed:20869434). Accelerated pro-oxidizing shift in the redox state (PubMed:20869434). Increase in the number of cells undergoing apoptosis in the thoracic muscles, digestive tract and oenocytes (PubMed:20869434). Reduction in night activity offset and age-dependent increase in temperature sensitive paralysis (PubMed:33585478). RNAi-mediated knockdown in motor neurons in a Prx5 null mutant background shortens life span and decreases negative geotaxis and phototaxis (PubMed:33585478).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:11677042). Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:11677042, PubMed:20869434, PubMed:23124252). May be involved in aging-associated changes in the responsiveness to oxidative stress (PubMed:23124252). Involved in the maintenance of global thiol redox homeostasis (PubMed:20869434). Functions in the central nervous system (CNS) and in motor neurons and is essential for normal motor function (PubMed:33889951, PubMed:33585478).

7227:Dmel CG9590
gene id: 7227:Dmel_CG9590
uniprot id: Q9VF39
names: Similarity
messages: Belongs to the FAM114 family.

7227:Dmel CG18107
gene id: 7227:Dmel_CG18107
uniprot id: Q8SYA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bomanin family.
messages: Secreted

7227:Dmel CG8599
gene id: 7227:Dmel_CG8599
uniprot id: E1JIJ9
uniprot id: P20193
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.
messages: Interacts with Su(var)39 through the BESS domain.
messages: Nucleus

7227:Dmel CG17743
gene id: 7227:Dmel_CG17743
uniprot id: Q8ST83
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Esc/E(z) complex, composed of Esc, E(z), Su(z)12, HDAC1/Rpd3 and Caf1-55. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Component of the chromatin remodeling Ino80 complex. Interacts with Sfmbt to form a pho-repressive complex (PhoRC).
messages: Maternally and zygotically expressed.
messages: Nucleus
messages: Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
messages: Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

7227:Dmel CG30274
gene id: 7227:Dmel_CG30274
uniprot id: Q8MMD7
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3497
gene id: 7227:Dmel_CG3497
uniprot id: P28159
uniprot id: X2JAI1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Su(H) family.
messages: Cytoplasm
messages: Despite some similarity with the 'phage' integrase family, PubMed:7958912 showed that it has no recombinase activity.
messages: Expressed in early syncytial embryo (PubMed:1617730, PubMed:1617729). During cellularization, transient accumulation in a striped pattern (PubMed:1617730, PubMed:1617729). From late stage 11 onward, expressed gradually in a small number of segmentally reiterated cells of the peripheral nervous system (PNS) (PubMed:1617730, PubMed:1617729). This expression is specific to the external sensory organs (PubMed:1617730). In the thoracic and abdominal segments, expressed in the trichogen and tormogen cells, two outer accessory cells present in all larval external sensory organs (PubMed:1617730). During the late third larval instar, expressed in many larval and imaginal tissues (PubMed:1617730). Broadly distributed in the disks, but most abundant in the posterior region of the wing pouch (PubMed:1617730). In the leg disk, predominant in a zone largely overlapping the posterior region (PubMed:1617730). In the eye-antenna disk, low level in both the retinal field posterior to the morphogenetic furrow and the central antenna region, while higher levels appears on the margins of the disk and in the vicinity of the morphogenetic furrow (PubMed:1617730). In pupae, expressed in many tissues at this stage, including developing muscle and epidermis (PubMed:1617730). In both microchaetes and macrochaetes of 24 hr pupae, expressed on the notum and the head (PubMed:1617730). Expressed in the tormogen cell and in specific bristle cells (PubMed:1617730).
messages: Interacts with activated cleaved Notch. Interacts with Hairless, this interaction preventing its DNA-binding activity. Interacts with insv (via BEN domain).
messages: Lethal during the first day of pupal development (PubMed:1617730). At the larval stage, results in a 'neurogenic' phenotype in imaginal disks, in which too many cells adopt the sensory organ precursor cell fate (PubMed:1617730). RNAi-mediated knockdown in type II neuroblasts, results in smaller cells (PubMed:1617730).
messages: Nucleus
messages: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:21262215, PubMed:1617729, PubMed:8674407, PubMed:10673509). Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:10673509). Acts as a transcriptional repressor when it is not associated with Notch proteins (PubMed:10673509). When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (PubMed:10673509). Required for transcription of Sim (PubMed:10673509). Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence (PubMed:1744127, PubMed:1617730, PubMed:1617729). Required for neurogenesis in imaginal disks (PubMed:1617730, PubMed:7813798). In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development (PubMed:21262215). Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell (PubMed:12642500).

7227:Dmel CG10505
gene id: 7227:Dmel_CG10505
uniprot id: Q9W2I5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG2222
gene id: 7227:Dmel_CG2222
uniprot id: Q9W2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

7227:Dmel CG15800
gene id: 7227:Dmel_CG15800
uniprot id: Q9W1J7
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG17046
gene id: 7227:Dmel_CG17046
uniprot id: A8JNH1
uniprot id: M9PBH0
uniprot id: M9PDJ0
uniprot id: M9PGK7
uniprot id: Q7YU15
uniprot id: Q9W0Q4
uniprot id: X2JAH4
names: Similarity
messages: Belongs to the nesprin family.

7227:Dmel CG15011
gene id: 7227:Dmel_CG15011
uniprot id: Q9VZF2
names: Similarity
messages: Belongs to the NFX1 family.

7227:Dmel CG18619
gene id: 7227:Dmel_CG18619
uniprot id: Q9VL14
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Chromosome
messages: Homodimer. Interacts (via C-terminus) with REPTOR (via C-terminus).
messages: Nucleus
messages: Sensitive to nutrient stress. Larvae display no obvious phenotype under normal feeding conditions; larval growth and development is normal, and there is no effect on triglyceride and glycogen levels. However when mutants pupate and become adults they display reduced triglyceride and glycogen stores leading to adults dying within 18 hours of starvation whereas controls survive 2.5 days without food. Larvae are also sensitive to nutrient stress displaying 50% lethality when fed a low nutrient diet.
messages: Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts to enhance the binding of the transcriptional activator REPTOR to the regulatory sequences of target genes. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking site for 14-3-3 proteins. Upon TORC1 inhibition resulting from nutrient stress, REPTOR is recruited into the nucleus where it interacts with REPTOR-BP and together they maintain organismal metabolism by activating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis. The complex also appears to negatively regulate some aspects of TORC1-dependent larval growth.

7227:Dmel CG3710
gene id: 7227:Dmel_CG3710
uniprot id: M9PFV9
uniprot id: P20232
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus
messages: S-II binds to RNA-polymerase II in the absence of transcription.

7227:Dmel CG11049
gene id: 7227:Dmel_CG11049
uniprot id: D1YSG9
uniprot id: O16117
uniprot id: Q59DN7
uniprot id: Q59DN8
uniprot id: Q59DN9
uniprot id: Q59DP0
uniprot id: Q8IM96
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5528
gene id: 7227:Dmel_CG5528
uniprot id: M9NDW9
uniprot id: Q9VPH1
names: Similarity
messages: Belongs to the Toll-like receptor family.

7227:Dmel CG3926
gene id: 7227:Dmel_CG3926
uniprot id: Q9W3Z3
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal 5'-phosphate-dependent transamination of alanine with glyoxylate as an amino group acceptor (PubMed:12220660). Can also catalyze, although with much less efficiency, the transamination of amino-butyrate, phenylalanine and serine with glyoxylate or pyruvate as an amino group acceptor (PubMed:12220660). Does not catalyze the transamination of both 3-hydroxykynurenine and L-kynurenine (PubMed:12220660). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the fly diet (Probable).
messages: Homodimer.
messages: Intron retention.
messages: Peroxisome
messages: RNAi-mediated knockdown causes accumulation of calcium oxalate crystals in Malpighian tubules.

7227:Dmel CG10895
gene id: 7227:Dmel_CG10895
uniprot id: A4V0X0
uniprot id: O61267
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CDS1 subfamily.
messages: Does not affect male germline stem cells maintenance (PubMed:34644293). In the germline, RNAi-mediated knockdown of Rtel1 in lok mutant background results in partial rescue of single Rtel1 knockdown phenotype which includes loss of germline stem cell and reduced levels of Stat92E expression (PubMed:34644293).
messages: Expressed both maternally and zygotically in adult females. Levels of the long isoform remain fairly constant from ovaries to embryos, the levels of short isoform decrease dramatically.
messages: In stage 3 embryos, both isoforms are expressed in both somatic and pole cell nuclei. Expression in pole cell nuclei is sustained until stage 9 and weakly expressed after pole cell invagination into the abdominal cavity.
messages: May have a role in germline establishment.
messages: Nucleus speckle

7227:Dmel CG12172
gene id: 7227:Dmel_CG12172
uniprot id: Q7KA66
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG9438
gene id: 7227:Dmel_CG9438
uniprot id: A0A075BR14
uniprot id: P33270
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones.
messages: Microsome membrane

7227:Dmel CG5577
gene id: 7227:Dmel_CG5577
uniprot id: Q8SXC0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG14341
gene id: 7227:Dmel_CG14341
uniprot id: Q7KU06
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

7227:Dmel CG42384
gene id: 7227:Dmel_CG42384
uniprot id: C0HJX4
uniprot id: C0HJX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: At early stages of embryogenesis, the polycistronic RNA is expressed in seven segmentally separated blastoderm stripes and in a cluster of cells in the anterior part of the embryo (PubMed:17439302). By stage 13 to the end of embryo development, it is expressed in the dorsal trunks, posterior spiracles, pharynx, hindgut and the area which forms the denticle belts (PubMed:17439302). In the leg disk, it is expressed in a ring pattern presumed to be developing tarsal region around 80 to 96 h after egg laying (AEL) and then in the tarsal furrow at the mid-third instar larval stage (PubMed:17439302, PubMed:18801356). Not detected in the tarsal primordium after 100h AEL but is still expressed in a dorsal chordotonal organ of the leg disk (PubMed:17439302). In pupae, expressed broadly throughout the leg disk 0-3 h after puparium formation (APF) but is not detected in this region 6h APF (PubMed:25344753). High expression 4-8 h APF in the presumptive joints between tarsal segments (PubMed:21682860). In the noctum expressed from 40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae, expressed in two anterior stripes and later in the precursors for chemosensory organs (PubMed:21682860). From late third stage instar larvae to early pupal stages, it is also expressed in the wing provein cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In eye disks, expressed in preclusters for presumptive R8 photoreceptors and in a stripe of cells in the posterior region of the disk (PubMed:21682860).
messages: Cytoplasm
messages: Interacts with Ubr3.
messages: Nucleus
messages: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114).
messages: Polycistronic RNA up-regulated by ecdysone.
messages: Simultaneous knockout of tal-1A, tal-2A, tal-3A and tal-AA is embryonic lethal (PubMed:17439302, PubMed:17486114). In embryos chitin secretion and formation of the cuticular exoskeleton appears to be normal (PubMed:17439302, PubMed:17486114). However embryos display a loss of denticle belts and dorsal hairs (PubMed:17439302, PubMed:17486114). Segment-specific epidermal sensory organs are present and segments form normally (PubMed:17439302). The cephalopharyngeal skeleton is lost, and the head skeleton and posterior spiracles are deformed (PubMed:17439302). In the developing leg, tarsal constriction occurs but the tarsal fold does not form (PubMed:17439302). The tracheal system is abnormal displaying a loss of network integrity, an irregular tube diameter and the absence of taenidial folds (PubMed:17439302, PubMed:17486114). Cell packing is not affected, but there is no accumulation of F-actin at the sites of denticle differentiation or formation of F-actin bundles during taenidial development and tracheal tube dilation (stages 14 and 16) (PubMed:17486114). Other F-actin based developmental processes such as filopodia formation of tracheal tip cells, dorsal closure, mitosis or tight packing of denticle cells are unaffected (PubMed:17486114). Denticle and tracheal defects can be rescued by ectopic expression of any one of the four tal peptides (tal-1A, tal-2A, tal-3A and tal-AA) (PubMed:17486114).
messages: This protein is produced by a polycistronic gene which also produces tal-1A, tal-3A and tal-AA from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).
messages: This protein is produced by a polycistronic gene which also produces tal-2A, tal-3A and tal-AA from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).

7227:Dmel CG31694
gene id: 7227:Dmel_CG31694
uniprot id: Q9VQI5
names: Similarity
messages: Belongs to the IFRD family.

7227:Dmel CG2851
gene id: 7227:Dmel_CG2851
uniprot id: B7Z003
uniprot id: P54366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears to regulate regional development of specific tissues. Can rescue axis polarity in UV-radiated Xenopus embryos.
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: In early embryo development, expression confined to two regions; a horseshoe-like pattern across the dorsal side which is destined to form the brain hemispheres and a second domain which invaginates inside the stomodeum and which, is fated to form the foregut, ring gland and stomatogastric nervous system (SNS).
messages: Nucleus

7227:Dmel CG9013
gene id: 7227:Dmel_CG9013
uniprot id: A1ZAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane

7227:Dmel CG18746
gene id: 7227:Dmel_CG18746
uniprot id: Q9I7K8
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG10889
gene id: 7227:Dmel_CG10889
uniprot id: Q8T0D9
names: Similarity
messages: Belongs to the ZC3H12 family.

7227:Dmel CG44240
gene id: 7227:Dmel_CG44240
uniprot id: A0A0B4LF73
uniprot id: A0A0B4LFE7
uniprot id: A0A0B4LGJ2
uniprot id: A8DYE2
uniprot id: B7YZH3
uniprot id: B7YZH4
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily.
messages: Calcium channel mediating constitutive calcium ion entry.
messages: Membrane
messages: Partially edited. Target of Adar.

7227:Dmel CG3403
gene id: 7227:Dmel_CG3403
uniprot id: Q7K0E3
names: Similarity
messages: Belongs to the MOB1/phocein family.

7227:Dmel CG1893
gene id: 7227:Dmel_CG1893
uniprot id: Q9VZW1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7227:Dmel CG32432
gene id: 7227:Dmel_CG32432
uniprot id: M9PG87
uniprot id: Q9VPA1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11196
gene id: 7227:Dmel_CG11196
uniprot id: A0A0B4LEV4
uniprot id: A1Z787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG6489
gene id: 7227:Dmel_CG6489
uniprot id: Q8INI8
uniprot id: Q9BIR7
uniprot id: Q9BIS2
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
messages: Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

7227:Dmel CG2595
gene id: 7227:Dmel_CG2595
uniprot id: P40809
names: Caution
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Expressed during spermatogenesis, in primary spermatocytes and imaginal disk morphogenesis.
messages: In pupae, expressed in imaginal disks and only in the male gonad. In adults; isoform 1 is the predominant form in the testes and is expressed at a low level in the ovary and somatic tissues, and isoform 2 is very weakly expressed and is detectable solely in the testes.
messages: Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac-bound GDP by GTP.
messages: It is uncertain whether Met-1 or Met-23 is the initiator.

7227:Dmel CG8253
gene id: 7227:Dmel_CG8253
uniprot id: A0A0B4K882
uniprot id: Q7K2Y9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Defects in long term memory after olfactory learning.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
messages: Monomer.

7227:Dmel CG31140
gene id: 7227:Dmel_CG31140
uniprot id: A0A0B4K716
uniprot id: A0A0B4KHZ4
uniprot id: A8JR94
uniprot id: Q7KS34
uniprot id: Q7KS35
uniprot id: Q9VCF2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7227:Dmel CG11092
gene id: 7227:Dmel_CG11092
uniprot id: Q9XZ06
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC) (By similarity). Interacts with msk (via C-terminus); this association might be facilitated by Nup75 (PubMed:20547758). Interacts with Mad (preferentially when phosphorylated) (PubMed:20547758). Interacts with Nup154 (via N-terminus) (PubMed:22718353). Interacts with the Polycomb group (PcG) proteins Pc and E(z) (PubMed:31784359).
messages: RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery, leading to disrupted karyosome morphology (PubMed:26341556). RNAi-mediated knockdown in the wing disk results in de-repression of genes silenced by the Polycomb group proteins complexes such Abd-B (PubMed:31784359).
messages: Required for nuclear pore complex assembly, maintenance and function (PubMed:20547758, PubMed:22718353). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets (PubMed:31784359). Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:26341556).
messages: nuclear pore complex
messages: nucleoplasm

7227:Dmel CG3322
gene id: 7227:Dmel_CG3322
uniprot id: P15215
uniprot id: X2JAW6
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Domains VI and IV are globular.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
messages: basement membrane

7227:Dmel CG30441
gene id: 7227:Dmel_CG30441
uniprot id: A1Z6F0
names: Subcellular Location Annotation
messages: cilium

7227:Dmel CG12264
gene id: 7227:Dmel_CG12264
uniprot id: Q9VKD3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters.
messages: Interacts with bcn92 and IscU (PubMed:29491838). Might form a complex with bcn92, IscU and fh (Probable).
messages: L-cysteine binding is slower in the presence of bcn92 and IscU (PubMed:29491838). Activation requires bcn92, IscU and fh (PubMed:29491838).
messages: Mitochondrion
messages: Nucleus
messages: Ubiquitous expression at high levels in any life stage.

7227:Dmel CG42616
gene id: 7227:Dmel_CG42616
uniprot id: Q8IP45
uniprot id: Q9V475
names: Similarity
messages: Belongs to the cullin family.

7227:Dmel CG34140
gene id: 7227:Dmel_CG34140
uniprot id: Q0E8K6
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

7227:Dmel CG17146
gene id: 7227:Dmel_CG17146
uniprot id: Q8IQG9
uniprot id: Q9VTV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

7227:Dmel CG12405
gene id: 7227:Dmel_CG12405
uniprot id: A1Z892
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

7227:Dmel CG2014
gene id: 7227:Dmel_CG2014
uniprot id: Q9VAK5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

7227:Dmel CG4537
gene id: 7227:Dmel_CG4537
uniprot id: Q9VL77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

7227:Dmel CG12251
gene id: 7227:Dmel_CG12251
uniprot id: E1JH55
uniprot id: Q7KY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7227:Dmel CG6658
gene id: 7227:Dmel_CG6658
uniprot id: Q9VGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG15864
gene id: 7227:Dmel_CG15864
uniprot id: Q9VHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG6776
gene id: 7227:Dmel_CG6776
uniprot id: Q9VSL2
names: Similarity
messages: Belongs to the GST superfamily. Omega family.

7227:Dmel CG43323
gene id: 7227:Dmel_CG43323
uniprot id: A0A0B4LFQ8
uniprot id: A0A126GUN4
uniprot id: A0A126GUN8
uniprot id: A1ZAV4
uniprot id: D2NUG1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG18140
gene id: 7227:Dmel_CG18140
uniprot id: M9PGH3
uniprot id: Q9W5U2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG33825
gene id: 7227:Dmel_CG33825
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG4406
gene id: 7227:Dmel_CG4406
uniprot id: Q8T4E1
names: Function
names: Similarity
messages: Belongs to the peptidase C13 family.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).

7227:Dmel CG40041
gene id: 7227:Dmel_CG40041
uniprot id: M0QVX8
uniprot id: Q4V4C8
uniprot id: Q8MLY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

7227:Dmel CG3171
gene id: 7227:Dmel_CG3171
uniprot id: M9NGQ9
uniprot id: Q9NDM2
uniprot id: X2JIG6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium.
messages: Expressed both maternally and zygotically throughout embryo to adult stages.
messages: In embryos, expression is seen at highest levels in the cuprophilic cells and at lower levels in the amnioserosa, developing CNS, cardiac mesoderm primordium and midline glia.
messages: Most germ cells do not exit the posterior midgut (PMG) and remain clumped together within the midgut pocket. The few germ cells that do leave the midgut early migrate normally to the gonad.
messages: Overexpression of the Tre1 gene restores the taste sensitivity to trehalose in a Tre1 mutant (PubMed:10884225). This experiment cannot be explained given that other authors demonstrate that trehalose sensitivity maps to the adjacent gene, Gr5a (PubMed:14691551).

7227:Dmel CG8193
gene id: 7227:Dmel_CG8193
uniprot id: Q9V521
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Chimeric cDNA. It is a chimera between Dox-A3 and PPO2.
messages: Expression is high during the larval stage, predominantly in the feeding and wandering larvae.
messages: Secreted
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinonee (By similarity).
messages: Upon activation, a trypsin type protease cleaves prophenol oxidase to yield the active enzyme.

7227:Dmel CG9920
gene id: 7227:Dmel_CG9920
uniprot id: Q9VFN5
names: Similarity
messages: Belongs to the GroES chaperonin family.

7227:Dmel CG12843
gene id: 7227:Dmel_CG12843
uniprot id: Q7JZW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG7831
gene id: 7227:Dmel_CG7831
uniprot id: A0A0B4LI25
uniprot id: P20480
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
messages: Minus-end-directed microtubule-based motor protein (PubMed:2146510, PubMed:8112290, PubMed:27452403). Has ATPase activity (PubMed:27452403). Required for normal chromosomal segregation in meiosis in females, and in early mitotic divisions of the embryo (PubMed:1691829).
messages: cytoskeleton

7227:Dmel CG11513
gene id: 7227:Dmel_CG11513
uniprot id: M9NDG7
uniprot id: Q6J5K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in oocytes and syncytial blastoderm. Expressed at low level throughout development, including somatic tissues. First apparent early in oogenesis, in the cytoplasm of stem cells and mitotically dividing cystoblasts. In regions 2a and 2b of the germarium, it is most concentrated in the center of the germline cysts, where the pro-oocyte is located. In stage 1 and early stage 2 egg chambers, it accumulates at the anterior of the oocyte, near the ring canals. It also extends through the ring canals forming a branched structure that links the early oocyte with adjacent nurse cells. In stage 3 cysts, it accumulates at the posterior cortex and localizes to extensions that pass through the oocyte into the nurse cells. Through stages 4 to 7, it continues to be somewhat enriched at the posterior cortex of the oocyte, but at significantly lower level. In stage 9 to 10 egg chambers, it is found throughout the cytoplasm of the oocyte and nurse cells, with slight enrichment at the oocyte cortex.
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: Cytoplasm
messages: Forms a complex with piwi and fs(1)Yb; this interaction is required for proper piRNA loading and nuclear localization of piwi. The interaction of piwi and fs(1)Yb is likely to occur via armi.
messages: Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and cytoskeletal polarization in the oocyte. Required for somatic primary piRNA biogenesis.

7227:Dmel CG14803
gene id: 7227:Dmel_CG14803
uniprot id: O46089
uniprot id: X2JA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Involved in recombination-dependent repair of stalled or collapsed replication forks.
messages: Nucleus

7227:Dmel CG31884
gene id: 7227:Dmel_CG31884
uniprot id: Q9V429
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Intron retention.
messages: Larval stages.
messages: Monomer.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.

7227:Dmel CG32445
gene id: 7227:Dmel_CG32445
uniprot id: Q8MR63
names: Similarity
messages: Belongs to the aldose epimerase family.

7227:Dmel CG3953
gene id: 7227:Dmel_CG3953
uniprot id: Q9VH19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Essential for the coordination of mitotic progression, and also plays a role in cell migration.

7227:Dmel CG4003
gene id: 7227:Dmel_CG4003
uniprot id: Q9VH07
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth.
messages: Belongs to the RuvB family.
messages: Death at first larval instar.
messages: Expressed both maternally and zygotically.
messages: Forms homohexameric rings. May form a dodecamer with rept made of two stacked hexameric rings (By similarity). Component of the chromatin remodeling Ino80 complex. Interacts with Myc and rept.
messages: Higher expression occurs in primordia of mesoderm, anterior and posterior midgut and cephalic furrow early in gastrulation, as well as in endoderm and mesoderm lineages during germ band extension. Later in development expression is only maintained in endoderm cells. Expressed in thoracic and abdominal segment neural precursors of all embryonic chordotonal organs.
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

7227:Dmel CG15117
gene id: 7227:Dmel_CG15117
uniprot id: A0A0B4LFU6
uniprot id: A0A0B4LGY4
uniprot id: A1ZBG9
uniprot id: A1ZBH0
uniprot id: Q7K173
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

7227:Dmel CG7598
gene id: 7227:Dmel_CG7598
uniprot id: Q9VAI1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIA30 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Larvae are viable but most do not survive the late pupa/early adult stages. Surviving adults that are assisted to eclose display severe degeneration of myofibrils and mitochondria.
messages: Mitochondrion

7227:Dmel CG5403
gene id: 7227:Dmel_CG5403
uniprot id: Q24573
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed maternally throughout the embryo at the syncytial cleavage divisions and zygotically at the termini and in a broad central band during cellularization. At germ band extension, the protein is found in the mesoderm. Expressed in a subset of neurons from larva and pupa.
messages: Flies show axon guidance abnormalities in mushroom bodies and pathfinding errors by photoreceptor and subesophageal neurons. Female flies with retn defects are strikingly resistant to male courtship and show male-like courtship of females and males, especially as they age.
messages: Nucleus
messages: Present in the pharyngeal muscles, hindgut epithelium, amnioserosa, ring gland, midgut-hindgut junction, posterior region of each brain lobe, longitudinal glial cells of the CNS and the salivary gland duct of germ-band retracted embryos.
messages: Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold.

7227:Dmel CG5638
gene id: 7227:Dmel_CG5638
uniprot id: Q9VTU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7227:Dmel CG14767
gene id: 7227:Dmel_CG14767
uniprot id: Q7KGU6
uniprot id: Q95R82
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

7227:Dmel CG17489
gene id: 7227:Dmel_CG17489
uniprot id: Q9W5R8
uniprot id: R9Q794
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU) (By similarity). Interacts with Fmr1 to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are Rm62, RpL11, AGO2 and Dcr-1 (PubMed:12368261).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG18009
gene id: 7227:Dmel_CG18009
uniprot id: M9PHD8
uniprot id: Q07DP5
uniprot id: Q8T052
names: Similarity
messages: Belongs to the TBP family.

7227:Dmel CG46385
gene id: 7227:Dmel_CG46385
uniprot id: A1Z743
uniprot id: A1Z745
uniprot id: Q8SXN9
names: Similarity
messages: Belongs to the TENT family.

7227:Dmel CG5371
gene id: 7227:Dmel_CG5371
uniprot id: P48591
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Heterodimer of a large and a small subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the M1 subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

7227:Dmel CG40196
gene id: 7227:Dmel_CG40196
uniprot id: Q7PL26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

7227:Dmel CG10534
gene id: 7227:Dmel_CG10534
uniprot id: C0HL64
uniprot id: C0HL65
names: Developmental Stage
names: Function
messages: Component of the cuticle of the larva.
messages: Expression begins in late embryo and end late third larval instar. Maximal expression is at the end of the first larval instar.

7227:Dmel CG9201
gene id: 7227:Dmel_CG9201
uniprot id: Q9VXU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

7227:Dmel CG1448
gene id: 7227:Dmel_CG1448
uniprot id: A0A0B4LHT3
uniprot id: Q9VAS7
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apicolateral cell membrane
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during embryogenesis (at protein level). Expressed in larvae and pupae.
messages: Heterooligomer of Inx2 (via cytoplasmic C-terminal region) and Inx3 (via cytoplasmic C-terminal region).
messages: In ovary, expressed in nurse cells and follicle cells. Expressed in embryonic epithelial cells. Ubiquitously expressed in stage 5 embryos. Expressed in foregut and hindgut from stage 11-17 and in proventriculus, epidermis and CNS in stage 16 embryos (at protein level). Expressed in anterior and ventral regions in stage 8 embryos. Repeating epidermal pattern emerges at stage 11, refines to one or two cells at each side of the segment borders by stage 13. Expressed in the imaginal wing disk. In pupae, expressed in the CNS and in secondary and tertiary pigment cells of the retina.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: Structural components of the gap junctions. Essential for proper epithelial development of the epidermis.
messages: gap junction

7227:Dmel CG8580
gene id: 7227:Dmel_CG8580
uniprot id: M9MRW4
uniprot id: Q9VS59
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.
messages: Belongs to the akirin family.
messages: Homozygous embryonic lethal; early to mid embryonic stages (PubMed:18066067). Embryos display a range of somatic body wall muscle defects (PubMed:22396663). Embryos show morphological defects in the heart, such as abnormal spacing between rows of aortic cells and abnormal patterning of the aortic outflow tract (PubMed:32950464).
messages: Interacts with dmap1 (PubMed:24947515). Interacts with bap60 and rel; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232, PubMed:32950464). Interacts with bap55; interaction is immune stimulation-dependent (PubMed:25180232). Interacts with twi (PubMed:22396663).
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response (PubMed:18066067, PubMed:22396663, PubMed:25180232, PubMed:32950464). Acts as a regulator of embryonic myogenesis by bridging Twist (twi) with the SWI/SNF-like Brahma complex, promoting expression of twi-regulated genes during myogenesis (PubMed:22396663). Effector of immune deficiency pathway (Imd) by acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel) (PubMed:18066067, PubMed:25180232, PubMed:32950464). Acts by bridging the NF-kappa-B factor Rel and the Brahma complex through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232). Not part of the Toll pathway (PubMed:18066067). Required for the formation of the heart by promoting expression ot tinman (tin) (PubMed:32950464).
messages: Nucleus
messages: Polyubiquitinated via 'Lys-63'-linked ubiquitin by Hyd, promoting interaction with rel.
messages: Ubiquitous.

7227:Dmel CG5885
gene id: 7227:Dmel_CG5885
uniprot id: Q9VL69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

7227:Dmel CG30018
gene id: 7227:Dmel_CG30018
uniprot id: V9H0I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG3690
gene id: 7227:Dmel_CG3690
uniprot id: Q9V3J5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG30160
gene id: 7227:Dmel_CG30160
uniprot id: Q7K2V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG4278
gene id: 7227:Dmel_CG4278
uniprot id: Q9NK57
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

7227:Dmel CG4931
gene id: 7227:Dmel_CG4931
uniprot id: Q9VF87
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CYFIP family.
messages: Cytoplasm
messages: Expressed throughout the life cycle with no major peaks of expression. In the embryo, uniquitously and highly expressed at precellular and cellular blastoderm stages.
messages: Flies display pupal lethality with defects in axon growth, branching and pathfinding, synaptic length and organization of the neuromuscular junction. They also display defects in cell morphology with cells exhibiting a starfish-like shape with multiple slender cell extensions and loss of actin filaments at the cell periphery (PubMed:12818175, PubMed:14588242, PubMed:15269173). RNAi-mediated knockdown in gamma-aminobutyric acid (GABA)ergic neurons, or specifically in the anterior paired lateral (APL) neurons or in the antennal lobe local interneurons (LNs), results in feeding-dependent socialization defects (PubMed:32200800).
messages: In the embryo, expressed mainly in the gut and in the developing central nervous system where high levels of expression are found in the CNS neuropile. Expression in the gut diminishes as development proceeds (at protein level). In the adult, expressed specifically in the nervous system.
messages: Interacts with Fmr1 and Rac1. Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds through its C-terminus directly to Hem.
messages: Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development (PubMed:12818175, PubMed:14588242, PubMed:15269173, PubMed:15385157). Plays a role in regulating mitochondrial activity, energy metabolism and membrane potential which maintains normal gamma-aminobutyric acid (GABA) signaling and ensures normal social behavior (PubMed:32200800).

7227:Dmel CG17896
gene id: 7227:Dmel_CG17896
uniprot id: Q7KW39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).

7227:Dmel CG3936
gene id: 7227:Dmel_CG3936
uniprot id: M9NE67
uniprot id: P07207
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Crystal structure of the ANK repeat domain shows that there are 7 repeats and the stabilizing C-terminal repeat enhances the protein stability by extending the ankyrin domain.
messages: Endosome
messages: Essential signaling protein which has a major role in many developmental processes (PubMed:3935325). Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination (PubMed:10935637, PubMed:15620650, PubMed:12909620, PubMed:18243100). Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex (PubMed:7671825). Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction (PubMed:11719214, PubMed:12369105, PubMed:3935325). Regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt; might also regulate dpn expression through the activation of the transcriptional regulator Su(H) (PubMed:27151950, PubMed:28899667, PubMed:20152183, PubMed:18342578, PubMed:23056424, PubMed:21262215).
messages: Homomer. Interacts with Su(H) when activated. Interacts with Dx via its ANK repeats. Interacts with Dl via the EGF repeats and the Dl EGF repeats. Interacts with Nedd4 and Su(dx). Interacts with O-fut1; the interaction glycosylates N and transports N to early endosomes. Interacts with Akap200; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: O-glycosylated (PubMed:27268051). Three forms of O-glycosylation (O-fucosylation, O-glucosylation and O-GlcNAcylation) are detected (PubMed:27268051). O-fucosylated by O-fut1 and fng in the EGF repeat domain inhibits both Serrate/Ser- and Delta/Dl-binding (PubMed:12909620, PubMed:10935637). O-glucosylation by rumi in the endoplasmic reticulum is necessary for correct folding and signaling (PubMed:18243100).
messages: RNAi-mediated knockdown in the larval brain neuroblasts abolishes the expression of pnt, induces the ectopic expression of erm, results in the ectopic expression of Ase in type II neuroblasts (NBs) and their premature loss (PubMed:18342578, PubMed:23056424, PubMed:27151950). Simultaneous RNAi-mediated knockdown of pnt partially restores normal neuroblast numbers and inhibits ectopic erm expression (PubMed:27151950).
messages: Ubiquitinated by Nedd4; which promotes ligand-independent endocytosis and proteasomal degradation. May also be ubiquitinated by Su(dx) and Cbl.
messages: Upon binding its ligands such as Delta or Serrate, it is cleaved (S2 cleavage) in its extracellular domain, close to the transmembrane domain. S2 cleavage is probably mediated by Kuz. It is then cleaved (S3 cleavage) downstream of its transmembrane domain, releasing it from the cell membrane. S3 cleavage requires Psn.

7227:Dmel CG31787
gene id: 7227:Dmel_CG31787
uniprot id: Q8INX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

7227:Dmel CG3000
gene id: 7227:Dmel_CG3000
uniprot id: Q9W4H9
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

7227:Dmel CG16892
gene id: 7227:Dmel_CG16892
uniprot id: Q9W351
names: Function
names: Subcellular Location Annotation
messages: Involved in mitotic spindle assembly.
messages: nuclear pore complex
messages: spindle

7227:Dmel CG12410
gene id: 7227:Dmel_CG12410
uniprot id: Q9W494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

7227:Dmel CG6851
gene id: 7227:Dmel_CG6851
uniprot id: Q9V3Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG5586
gene id: 7227:Dmel_CG5586
uniprot id: A0A0B4KHZ3
uniprot id: A0A0B4KI44
uniprot id: Q9VB18
names: Similarity
messages: Belongs to the TUB family.

7227:Dmel CG7798
gene id: 7227:Dmel_CG7798
uniprot id: A1ZAB8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7227:Dmel CG10681
gene id: 7227:Dmel_CG10681
uniprot id: M9PFF6
uniprot id: Q9VTY4
names: Similarity
messages: Belongs to the KXD1 family.

7227:Dmel CG5645
gene id: 7227:Dmel_CG5645
uniprot id: Q9VTU0
names: Similarity
messages: Belongs to the KRI1 family.

7227:Dmel CG42872
gene id: 7227:Dmel_CG42872
uniprot id: B8A3Y2
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 5 family.

7227:Dmel CG4907
gene id: 7227:Dmel_CG4907
uniprot id: Q9VCV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

7227:Dmel CG5940
gene id: 7227:Dmel_CG5940
uniprot id: M9NFR3
uniprot id: P14785
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600. Interacts (via C-terminus) with Z600.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

7227:Dmel CG13390
gene id: 7227:Dmel_CG13390
uniprot id: Q9VLN0
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

7227:Dmel CG34195
gene id: 7227:Dmel_CG34195
uniprot id: A1ZAY5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

7227:Dmel CG10489
gene id: 7227:Dmel_CG10489
uniprot id: Q9VRQ7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Has a role in the entrance and progression through S phase (PubMed:24224125). Has a role in endoreplication (PubMed:24224125). Essential for viability and tissue development (PubMed:24224125).
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Component of the epsilon DNA polymerase complex consisting of four subunits: the catalytic subunit PolE1/DNApol-epsilon255 and the accessory subunits PolE2/DNApol-epsilon58, Chrac-14/DNApolE3 and PolE4.
messages: Expressed in the embryo and larva (at protein level).
messages: Nucleus
messages: Pupal lethal (PubMed:24224125). Results in smaller eye, leg and wing disk, brain lobe and salivary glands (PubMed:24224125). Results in defective entry and/or progression though S phase during the cell cycle in eye imaginal disk cells (PubMed:24224125). Results in defective endoreplication in salivary glands (PubMed:24224125).

7227:Dmel CG31454
gene id: 7227:Dmel_CG31454
uniprot id: Q8INQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

7227:Dmel CG45110
gene id: 7227:Dmel_CG45110
uniprot id: A0A0B4KHQ8
uniprot id: A0A0B4KI45
uniprot id: A0A0B4LHS3
uniprot id: A0A0B4LHV0
uniprot id: A0A0B4LIS6
uniprot id: A0A0B4LIT4
uniprot id: A0A126GV16
uniprot id: Q9VB13
uniprot id: Q9VB15
names: Subcellular Location Annotation
messages: cytoskeleton

7227:Dmel CG10970
gene id: 7227:Dmel_CG10970
uniprot id: Q9W3A0
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17212
gene id: 7227:Dmel_CG17212
uniprot id: Q86BL6
uniprot id: X2J9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

7227:Dmel CG9045
gene id: 7227:Dmel_CG9045
uniprot id: P04197
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, HDAC1/Rpd3 and l(3)mbt.
messages: DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes.
messages: Nucleus

7227:Dmel CG9805
gene id: 7227:Dmel_CG9805
uniprot id: Q9VN25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex (By similarity) (PubMed:17392269). The eIF-3 complex interacts with pix (By similarity) (PubMed:17392269).
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

7227:Dmel CG15396
gene id: 7227:Dmel_CG15396
uniprot id: P83292
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons and labral sense organ. Expressed in neurons of the dorsal pharyngeal sense organ of larvae.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG6128
gene id: 7227:Dmel_CG6128
uniprot id: Q9VTJ4
names: Caution
names: Function
names: Similarity
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Lacks the cysteine thought to be important for catalysis. It is replaced by Ala-288.

7227:Dmel CG42300
gene id: 7227:Dmel_CG42300
uniprot id: Q9VXT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

7227:Dmel CG32853
gene id: 7227:Dmel_CG32853
uniprot id: P83119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG14683
gene id: 7227:Dmel_CG14683
uniprot id: Q9VGY5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase.

7227:Dmel CG5454
gene id: 7227:Dmel_CG5454
uniprot id: Q9VE17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulates alternative splicing of a distinct group of target genes.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

7227:Dmel CG1126
gene id: 7227:Dmel_CG1126
uniprot id: Q9I7P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS5 family.
messages: Membrane
messages: centriolar satellite
messages: cilium membrane

7227:Dmel CG8937
gene id: 7227:Dmel_CG8937
uniprot id: P29843
uniprot id: Q8I0E9
names: Developmental Stage
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock cognate proteins are expressed constitutively during normal development.

7227:Dmel CG15329
gene id: 7227:Dmel_CG15329
uniprot id: Q9W3M9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MEIOB family.
messages: Interacts with mei-9 and Ercc1.
messages: Reduced meiotic crossover formation and sensitivity to the DNA-damaging agent methyl methanesulfonate (MMS).
messages: Single-stranded DNA-binding protein required for meiosis. May be involved in the resolution of recombination intermediates into crossovers in the meiotic recombination pathway.

7227:Dmel CG11051
gene id: 7227:Dmel_CG11051
uniprot id: Q9VU58
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection (at protein level).
messages: Hemolymph (at protein level).
messages: Secreted

7227:Dmel CG34357
gene id: 7227:Dmel_CG34357
uniprot id: A8JQT1
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

7227:Dmel CG12387
gene id: 7227:Dmel_CG12387
uniprot id: P42280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG12918
gene id: 7227:Dmel_CG12918
uniprot id: Q7JXF7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the canopy family.
messages: Endoplasmic reticulum
messages: Expressed in blastoderm embryos (at protein level). Abundantly expressed in late-stage embryos including in the developing salivary glands (at protein level).
messages: Formation of embryos with altered dorsal-ventral patterning, dramatically decreased levels of ea in the perivitelline space and reduced processing of ea.
messages: Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing.

7227:Dmel CG6535
gene id: 7227:Dmel_CG6535
uniprot id: Q5EAK6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Expressed at low levels throughout development and at much higher levels in adult females compared to males.
messages: Flies die shortly before or after eclosion with a rough eye phenotype, misshapen wings, and missing or abnormal bristles (PubMed:15256487). Shows increased numbers of spontaneous tumors (PubMed:15256487). Simultaneous knockout of tefu and Clbn/NEMF increases the formation of spontaneous tumors (PubMed:22964637).
messages: Nucleus
messages: Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV.
messages: telomere

7227:Dmel CG13162
gene id: 7227:Dmel_CG13162
uniprot id: A1Z8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rotatin family.
messages: Interacts with Rcd4;this complex is recruited to daughter centrioles before their conversion to centrosomes.
messages: Participes in the structural integrity of both centrioles and basal bodies and in centriole cohesion (PubMed:19948479). Participates in the later stages of centriole assembly through the interaction with Rcd4 leading to the centriole to centrosome conversion (PubMed:32543652).
messages: centriole

7227:Dmel CG17027
gene id: 7227:Dmel_CG17027
uniprot id: Q9VUW4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG5064
gene id: 7227:Dmel_CG5064
uniprot id: Q9VSS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), Srp72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with Srp72 (By similarity). Srp68/Srp72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: Srp72, Srp68, Srp54, Srp19, Srp14 and Srp9 (By similarity).
messages: nucleolus

7227:Dmel CG43443
gene id: 7227:Dmel_CG43443
uniprot id: A0A0B4K7A5
uniprot id: A0A0B4K849
uniprot id: A8DYJ2
uniprot id: Q02645
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Hu-li tai shao' means 'too little nursing' in Chinese.
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Isoform C is expressed in nurse cells. Isoform A is produced in the nurse cell but transported into the oocyte at stage 1, localizes to the oocyte cortex at stage 8 and to the anterior pole from day 9 onwards. Isoform B is expressed in the somatic follicle cells that surround the germline.
messages: Oogenesis and early embryogenesis.
messages: Required for assembling actin at ring canals in developing egg chambers. Probably interacts with other developmental proteins involved in nurse cell/oocyte transport through the ring canals. Important for normal neuromotor function (PubMed:23836506).
messages: cytoskeleton

7227:Dmel CG42250
gene id: 7227:Dmel_CG42250
uniprot id: Q8IN05
names: Similarity
messages: Belongs to the TEL2 family.

7227:Dmel CG7255
gene id: 7227:Dmel_CG7255
uniprot id: Q0E8E5
uniprot id: Q2PDY3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11265
gene id: 7227:Dmel_CG11265
uniprot id: Q7KVS9
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm
messages: High expression in unfertilized eggs and from 0 to 4 hours in early embryos. Low expression in later developmental stages, with slight increase in 8-16 hour-old embryos and in adults.
messages: Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information (PubMed:18765642, PubMed:26786835). Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (PubMed:26786835). Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs (PubMed:18765642, PubMed:26786835).
messages: Low activity with Mg(2+).
messages: RNAi-mediated knockdown causes lethality at the third-instar larval or early pupal stage.

7227:Dmel CG2759
gene id: 7227:Dmel_CG2759
uniprot id: P10090
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters, metabolic intermediates and second messengers (PubMed:812484, PubMed:117796, PubMed:6788034, PubMed:10407069, PubMed:18310115, PubMed:18931318, PubMed:33820991). In the eye, required for the transport of the eye red and brown pigment precursors, guanine and tryptophan, into pigment cell granules (PubMed:10407069, PubMed:8144619). Probably in association with bw/brown, involved in the transport of guanine (PubMed:117796). Probably in association with st/scarlet involved in the transport of kynurenine and probably tryptophan (PubMed:812484). Involved in the transport of kynurenine in pupal eyes (PubMed:812484). May play a role in histamine uptake by the lamina epithelial glia which surrounds photoreceptors R1-R6 (PubMed:18931318). In Malpighian tubules, involved in the transport of cGMP, guanine, xanthine, riboflavin, kynurenine and tryptophan (PubMed:812484, PubMed:117796, PubMed:6788034, PubMed:18310115). Probably in association with br/brown, involved in aging-induced intestinal stem cell proliferation in the midgut by regulating tetrahydrofolate transport (PubMed:33820991). Probably in association with st/scarlet, plays a role in zinc storage granule biogenesis in Malpighian tubule principal epithelial cells (PubMed:29367274).
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cytoplasmic vesicle membrane
messages: Expressed in the head (at protein level) (PubMed:11294610). Expressed in the eye, specifically in retina primary pigment cells, in the basement membrane of the base of secondary and tertiary pigment cells, and in retinula cells (at protein level) (PubMed:18931318, PubMed:11294610). Expressed in the retina underlying lamina in the epithelial glia that surrounds the array of lamina cartridges (at protein level) (PubMed:18931318). Weakly expressed in photoreceptors, specifically in terminals of R1-R6, R7 and R8 (at protein level) (PubMed:18931318). Expressed at very low levels in medulla and central brain (at protein level) (PubMed:18931318). Expressed in principal cells of the Malpighian tubules (PubMed:33820991).
messages: Eyes are white due to a defect in color pigment production (PubMed:18310115, PubMed:33820991). Malpighian tubules appear clear or white (PubMed:18310115, PubMed:29367274). Loss of st/scarlet protein in the pigment cells and retinula cells of the compound eye (PubMed:11294610). Transport of cGMP, but not cAMP, is inhibited in Malpighian tubules; however, basal fluid transport rates or rates stimulated by cGMP in the tubules are normal (PubMed:18310115). In Malpighian tubules, uptake of guanine, xanthine and riboflavin is impaired while uptake of hypoxanthine, guanosine and adenine is not affected (PubMed:117796). In Malpighian tubules, kynurenine and tryptophan uptake is impaired; however, incorporation of tryptophan into proteins is not affected (PubMed:6788034, PubMed:812484). In pupal eyes, kynurenine uptake is impaired (PubMed:812484). In the head, 50% reduction in histamine levels, 60% reduction in dopamine levels and 32% reduction in serotonin (5-HT) levels (PubMed:18931318). Specifically, histamine levels are reduced in the retina, the retina lamina and the central brain (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, numbers of synaptic vesicles and capitate projections, which are sites of endocytosis of vesicle membrane, are reduced (PubMed:18931318). In young and old flies, reduces the levels of several metabolites, including tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, guanosine, xanthine, riboflavin and tetrahydrofolate, and increases the levels of guanine (PubMed:33820991). Inhibits aging-induced intestinal stem cell proliferation (PubMed:33820991). 3-fold reduction in Malpighian tubule zinc stores (PubMed:29367274). Severe reduction of copulation success and reduced courting activities in males (PubMed:28794482). RNAi-mediated knockdown in central nervous system causes a delay in locomotor recovery from anoxia with no effect on eye pigmentation (PubMed:27029736). RNAi-mediated knockdown in serotonergic neurons, c…
messages: May form a heterodimer with bw/brown (Probable). May form a heterodimer with st/scarlet (Probable).
messages: Up-regulated during aging in intestinal stem cells.

7227:Dmel CG11815
gene id: 7227:Dmel_CG11815
uniprot id: Q9W057
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

7227:Dmel CG4317
gene id: 7227:Dmel_CG4317
uniprot id: Q9W438
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

7227:Dmel CG43065
gene id: 7227:Dmel_CG43065
uniprot id: Q0E8R3
uniprot id: Q7K108
uniprot id: Q86BL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm

7227:Dmel CG42342
gene id: 7227:Dmel_CG42342
uniprot id: B7Z0K8
names: Subcellular Location Annotation
messages: Cell membrane

7227:Dmel CG10555
gene id: 7227:Dmel_CG10555
uniprot id: Q9W3G1
names: Similarity
messages: Belongs to the SS18 family.

7227:Dmel CG10145
gene id: 7227:Dmel_CG10145
uniprot id: Q7JY80
names: Subcellular Location Annotation
messages: extracellular matrix

7227:Dmel CG4770
gene id: 7227:Dmel_CG4770
uniprot id: Q9VDS1
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG4432
gene id: 7227:Dmel_CG4432
uniprot id: A0A0S0WMR4
uniprot id: E1JI88
uniprot id: E1JI89
uniprot id: M9NDN2
uniprot id: Q9GNK5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Expressed during larval and pupal stages.
messages: Expressed in the fat body and hemocytes.
messages: Larvae infected with Gram-negative bacteria fail to induce tracheal expression of the antimicrobial peptide gene Drs.
messages: Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response (PubMed:11872802, PubMed:22022271). Required for Relish processing and nuclear translocation following proteolytic cleavage (PubMed:11872802). Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria (PubMed:11872802). The different isoforms probably display different recognition capabilities to various microbial patterns (PubMed:12777387, PubMed:16006509).
messages: Mediates the response to LPS and Gram-negative bacteria.
messages: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria.
messages: Membrane

7227:Dmel CG46438
gene id: 7227:Dmel_CG46438
uniprot id: E1JIB2
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adults produce fewer progeny (PubMed:29764939). Larvae display an increase in survival when fed a diet enriched with 3-chloro-L-tyrosine (Cl-Tyr), whereas survival is unaffected when fed a diet containing 3-iodo-L-tyrosine (I-Tyr) or 3-bromo-L-tyrosine (Br-Tyr) (PubMed:29764939). Adult survival is unaffected when fed a diet supplemented with halotyrosines (PubMed:29764939).
messages: Belongs to the nitroreductase family.
messages: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:27643701). Activity towards 3-fluoro-L-tyrosine is weak (PubMed:27643701). Important for male and female fertility (PubMed:29764939). May be involved in maintaining the viability of sperm, both during development in the testes and storage in the female spermatheca (PubMed:29764939).
messages: Cell membrane
messages: Expressed in spermatocytes.
messages: Homodimer.
messages: Named condet in honor of Dr. Jean Francois Condet who discovered that ingestion of iodide could reduce goiter.

7227:Dmel CG43619
gene id: 7227:Dmel_CG43619
uniprot id: O46201
names: Function
names: Subcellular Location Annotation
messages: Responsible for physiological and behavioral changes in mated female flies.
messages: Secreted

7227:Dmel CG32434
gene id: 7227:Dmel_CG32434
uniprot id: E1JI59
uniprot id: Q6U9V3
uniprot id: Q7KTX2
uniprot id: Q9VP80
names: Similarity
messages: Belongs to the BRAG family.

7227:Dmel CG11637
gene id: 7227:Dmel_CG11637
uniprot id: Q9VVT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Homophilic transmembrane adhesion molecule that mediates cell adhesion (By similarity). Able to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules that propagate the inflammatory response (PubMed:33472215).
messages: Membrane

7227:Dmel CG3841
gene id: 7227:Dmel_CG3841
uniprot id: Q9VLA4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG9067
gene id: 7227:Dmel_CG9067
uniprot id: A1Z8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

7227:Dmel CG10480
gene id: 7227:Dmel_CG10480
uniprot id: P25171
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to chromatin.

7227:Dmel CG33495
gene id: 7227:Dmel_CG33495
uniprot id: D1Z366
uniprot id: P81160
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ductus ejaculatorius.
messages: Induces post-mating responses; increased oviposition and reduced receptivity.
messages: Secreted
messages: To paragonial peptide B.

7227:Dmel CG10236
gene id: 7227:Dmel_CG10236
uniprot id: Q00174
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth.
messages: Domains VI, IV and G are globular.
messages: During morphogenesis, mostly in embryo development at 10-12 hours.
messages: Flies show late embryonic lethality. Certain partial loss-of-function mutations give raise to escaper adults, which have rough eyes associated with changes in cell fate and pattern, misshappen legs and defects in wing structure.
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: Newly formed mesoderm and later prominently expressed in hemocytes, which also synthesize collagen IV. Expressed in muscles.
messages: Synapse
messages: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
messages: axon
messages: basement membrane
messages: synaptic vesicle

7227:Dmel CG9493
gene id: 7227:Dmel_CG9493
uniprot id: Q9V3V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

7227:Dmel CG1594
gene id: 7227:Dmel_CG1594
uniprot id: Q24592
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Expressed both maternally and zygotically throughout development.
messages: Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.
messages: Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 (By similarity).
messages: Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.

7227:Dmel CG3502
gene id: 7227:Dmel_CG3502
uniprot id: Q9W1S1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG2145
gene id: 7227:Dmel_CG2145
uniprot id: Q9VZ49
uniprot id: X2JJD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENDOU family.
messages: Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.
messages: Monomer.
messages: Secreted

7227:Dmel CG18094
gene id: 7227:Dmel_CG18094
uniprot id: Q9VIV5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7227:Dmel CG31794
gene id: 7227:Dmel_CG31794
uniprot id: D3DMM0
uniprot id: Q2PDT4
uniprot id: Q8INW7
uniprot id: Q966T5
uniprot id: Q9VIX2
uniprot id: Q9VIX3
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

7227:Dmel CG3949
gene id: 7227:Dmel_CG3949
uniprot id: D2NUK9
uniprot id: Q9U3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity).
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

7227:Dmel CG11711
gene id: 7227:Dmel_CG11711
uniprot id: Q8IQG1
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOB1/phocein family.
messages: Cytoplasm
messages: Interacts with and activates trc, also interacts with wts.
messages: Nucleus
messages: Partially edited. Target of Adar.
messages: Required for the normal morphogenesis of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.

7227:Dmel CG32210
gene id: 7227:Dmel_CG32210
uniprot id: Q9VW09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase l(3)76BDr/LTN1 and Clbn/NEMF. The complex probably also contains TCF25 as well as TER94/VCP and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.
messages: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:25128630). Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity).
messages: cytosol

7227:Dmel CG7650
gene id: 7227:Dmel_CG7650
uniprot id: Q9VUR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosducin family.
messages: Forms a complex with the beta and gamma subunits of the GTP-binding proteins. Interacts with the CCT chaperonin complex (By similarity).
messages: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

7227:Dmel CG31622
gene id: 7227:Dmel_CG31622
uniprot id: P58956
uniprot id: P58957
uniprot id: P58958
uniprot id: P58959
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons and adult thorax and abdomen.
messages: Expressed in the adult labellar chemosensory neurons, and adult thorax and wing. In larvae, is expressed in neurons of the posterior pharyngeal sense organ.
messages: Expressed in the adult labellar chemosensory neurons. In larvae, is expressed in neurons of the terminal external chemosensory organ, as well as in the dorsal and posterior pharyngeal sense organs.
messages: Expressed in the adult labellar chemosensory neurons. In larvae, is expressed in neurons of the terminal external chemosensory organ, as well as in the dorsal pharyngeal sense organ.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone.
messages: Leads to reduced courtship levels toward females.

7227:Dmel CG9776
gene id: 7227:Dmel_CG9776
uniprot id: Q9V468
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3433
gene id: 7227:Dmel_CG3433
uniprot id: Q9V3D2
uniprot id: X2J9R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).

7227:Dmel CG17911
gene id: 7227:Dmel_CG17911
uniprot id: Q9VHQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG4560
gene id: 7227:Dmel_CG4560
uniprot id: Q9VF28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

7227:Dmel CG1983
gene id: 7227:Dmel_CG1983
uniprot id: Q9VA97
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

7227:Dmel CG10810
gene id: 7227:Dmel_CG10810
uniprot id: A0A1B2AJW2
uniprot id: P41964
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection (at protein level) (PubMed:9736738). In hemolymph 6 hours after bacterial infection, levels of expression increase for first 24 hours and persist for the following three weeks (at protein level) (PubMed:9736738). Up-regulated by septic injury caused by the Gram-positive bacterium M.luteus and the fungus C.albicans, and by M.luteus or E.faecalis-derived peptidoglycans and by B.subtilis or A.oryzae proteases (PubMed:19590012). Up-regulated by Gram-negative bacteria in the respiratory epithelium (PubMed:22022271). Up-regulated in the trachea and fat body in response to tracheal melanization, either by spontaneous melanization or melanization resulting from infection by bacteria (E.coli and M.luteus) or the fungus B.bassiana (PubMed:18854145).
messages: Hemolymph (at protein level) (PubMed:9736738). Synthesized in the fat body and is secreted into the blood (PubMed:9736738). In larvae, expressed in the visceral branches and posterior spiracles of the trachea (PubMed:22022271).
messages: Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi (PubMed:8808632, PubMed:12872120). It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology (PubMed:7806546). Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway (PubMed:8808632). Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system (PubMed:18854145).
messages: Secreted

7227:Dmel CG6238
gene id: 7227:Dmel_CG6238
uniprot id: D3PFH9
uniprot id: E1JIW2
uniprot id: Q6NN85
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Interacts with actin.
messages: Protein phosphatase which regulates actin filament dynamics (PubMed:11832213, PubMed:16169194). Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly (PubMed:11832213). Required for axon growth (PubMed:15572110).
messages: Strongly expressed in apical regions of the assembling ommatidia of the eye-imaginal disk. Apical expression requires the receptor tyrosine kinases Egfr and sev/sevenless.
messages: Tyrosine phosphatase activity has not been demonstrated for this protein to date.
messages: cytoskeleton

7227:Dmel CG2196
gene id: 7227:Dmel_CG2196
uniprot id: A0A0B4LHY2
uniprot id: Q9V9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG18313
gene id: 7227:Dmel_CG18313
uniprot id: Q9VY34
names: Similarity
messages: Belongs to the NAC-beta family.

7227:Dmel CG30361
gene id: 7227:Dmel_CG30361
uniprot id: A0A0B4KF15
uniprot id: A1Z7F4
uniprot id: A1Z7F5
uniprot id: A1Z7F6
uniprot id: B7YZT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG33261
gene id: 7227:Dmel_CG33261
uniprot id: Q08605
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the central nervous system throughout development.
messages: Expressed ubiquitously during embryogenesis with higher levels found from 9-12 hours after egg laying. Low levels are found in larvae and adults.
messages: Interacts with Bin1, lolal, corto, ttk and ph-p (PubMed:11256608, PubMed:12384587, PubMed:12834867, PubMed:12771214). Interacts with FACT subunits Ssrp and dre4/SPT16 (PubMed:12815073). Interacts with E(bx) (PubMed:11583616). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
messages: Nucleus
messages: The N-terminal BTB domain mediates protein oligomerization. The C-terminal glutamine-rich region is required for transcriptional activation activity.
messages: The N-terminus is blocked.
messages: Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription. Required for dosage compensation in males and may be involved in oogenesis. Also has a role in nuclear division.

7227:Dmel CG5680
gene id: 7227:Dmel_CG5680
uniprot id: E1JHD6
uniprot id: P92208
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation by the dual specificity kinase, hep. Inhibited by dual specificity phosphatase, puckered.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme.
messages: During gastrulation, expression is seen in cells undergoing morphogenetic movements. By stage 9 of embryonic development, expression is ubiquitous. At stages 12-14, expression occurs in epidermis and central nervous system. At stage 15, expression is restricted to ventral nerve cord, brain and some peripheral neurons. In larvae, expression is seen in all imaginal disks, with highest levels in wing and eye disks, and in the CNS. Adults express the protein in fat body and hemocytes.
messages: Expressed maternally and zygotically through to adult (male and female).
messages: In neuronal cells by wounding of the integument (at protein level) (PubMed:22227521). Activated by increased levels of reactive oxygen species (ROS) (PubMed:25594180).
messages: Interacts with MKP-4 (via tyrosine-protein phosphatase domain); the interaction dephosphorylates bsk.
messages: Nucleus
messages: RNAi-mediated knockdown results in reduced levels of DIP2.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity (PubMed:9224720). Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis (PubMed:8946915, PubMed:9224720, PubMed:10433922, PubMed:11784101). Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade (PubMed:22227521). Exhibits cytoprotective activity in neuronal cells in response to wounding to the integument (PubMed:22227521). Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure (PubMed:10433922, PubMed:11784101). Regulates the activity of SREBP in neurons and thereby the accumulation of lipids in glia (PubMed:25594180). Plays a role in positively regulating the expression of DIP2 independently of AP-1, thereby ensuring proper axon guidance in mushroom bodies (PubMed:28396149).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

7227:Dmel CG1391
gene id: 7227:Dmel_CG1391
uniprot id: E1JJ98
uniprot id: P27398
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Has a role in eye development.
messages: Mutants cause specific cells to degenerate in the developing optic lobes, resulting in the absence of certain classes of columnar neurons.
messages: Present throughout development, with expression levels lower in larvae than other life stages.

7227:Dmel CG4267
gene id: 7227:Dmel_CG4267
uniprot id: Q9VQ96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG1937
gene id: 7227:Dmel_CG1937
uniprot id: A0A0B4KHH2
uniprot id: Q95SP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer (By similarity). Interacts with p53. May interact with Septin2.
messages: Membrane
messages: The RING-type zinc finger is required for E3 ligase activity.

7227:Dmel CG12184
gene id: 7227:Dmel_CG12184
uniprot id: M9PJ28
uniprot id: Q961M4
uniprot id: Q9W4J0
names: Subcellular Location Annotation
messages: centrosome

7227:Dmel CG15087
gene id: 7227:Dmel_CG15087
uniprot id: Q8MSY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex.
messages: May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

7227:Dmel CG10851
gene id: 7227:Dmel_CG10851
uniprot id: A0A0C4DHG5
uniprot id: P26686
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin.
messages: Expressed throughout development.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus

7227:Dmel CG32236
gene id: 7227:Dmel_CG32236
uniprot id: Q95U06
names: Similarity
messages: Belongs to the CFAP97 family.

7227:Dmel CG17248
gene id: 7227:Dmel_CG17248
uniprot id: Q9W0C1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptobrevin family.
messages: Early endosome membrane
messages: Embryos develop normally, but their nerve terminals do not release transmitter in response to an action potential (PubMed:9482790). Spontaneous neurotransmitter release is reduced, but not abolished (PubMed:9482790, PubMed:10460261). Slow degeneration in adult photoreceptor neurons is also observed: defects are caused by an accumulation of endosomal vesicles, leading to transmembrane protein degradation defects and a secondary increase in autophagy (PubMed:22270918).
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane (PubMed:12364587, PubMed:22270918). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters (PubMed:9482790, PubMed:12364587). Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (PubMed:12364587). Also involved in a neuron-specific sort-and-degrade mechanism that promotes endolysosomal degradation and is required for neuronal maintenance (PubMed:22270918).
messages: Part of the SNARE core complex containing Snap25 and syntaxin.
messages: Specifically expressed in neurons and synapses.
messages: Transcripts are first detectable at stage 13 or 14 (PubMed:8229205). The expression is restricted to the nervous system, becoming quite robust in both the central and peripheral nervous system (CNS and PNS, respectively) by late embryogenesis (PubMed:8229205).
messages: synaptic vesicle membrane

7227:Dmel CG30142
gene id: 7227:Dmel_CG30142
uniprot id: Q8MKJ4
names: Function
names: Similarity
messages: Belongs to the PBP/GOBP family.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.

7227:Dmel CG3850
gene id: 7227:Dmel_CG3850
uniprot id: Q7K0S9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Specifically expressed in gut, fat body and Malpighian tubules of sugar-fed larvae.
messages: Strongly and rapidly induced in larvae by maltose, trehalose, glucose, fructose or saccharose, but not by lactose or galactose.
messages: Transcription factor which represses a set of lipase genes involved in fat catabolism.

7227:Dmel CG14814
gene id: 7227:Dmel_CG14814
uniprot id: Q7KW09
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine-aspartate repeat-containing protein (SDr) family.
messages: Chromosome
messages: Cytoplasm
messages: Homozygous mutant females initially laid eggs but stopped after approximately one week. Many of the embryos derived from these eggs exhibited maternal-effect lethality (PubMed:31839537). The few adults from F1 progeny of homozygous mutant females appear sickly and sub-fertile. Of these, 4% display bilateral gynandromorphism a rare phenotype caused by X chromosome loss during the early embryogenesis. By contrast, embryos from homozygous mutant females displayed X chromosome bridges and second chromosome missegregation and polyploidy (PubMed:31839537).
messages: May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:31839537). Limits replication stress and DNA double-strand breaks (PubMed:31839537).

7227:Dmel CG9586
gene id: 7227:Dmel_CG9586
uniprot id: M9PD03
uniprot id: Q8SYU0
names: Similarity
messages: Belongs to the CCDC43 family.

7227:Dmel CG31753
gene id: 7227:Dmel_CG31753
uniprot id: M9PBD2
uniprot id: Q8I7Z8
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the developing peripheral nervous system (PNS). Expressed in the ventral patch in the cephalic region of the embryo from stage 5, and continues in cephalic region through stage 15. Expressed in the developing PNS from stage 11 to 15, with a transient expression in each PNS cluster. In the ESOP lineage, it is first expressed in the IIIB cell, and in both ES and th cells, although it is only transiently expressed in th cells. In the ESOP lineage in the adult, it is also expressed in the IIIB cell and inherited by its daughter cells, as in the embryo.
messages: Nucleus
messages: Transcription factor that plays a crucial role in external sensory organ (ESO) that elaborates from a single precursor cell (ESOP cell). Mediates the differentiation of lineage branch that generates the internal 'ES' and 'th' cells (external sensory neuron and thecogen cells, respectively) from the IIIB cell. Its absence leads to re-specification of IIIB daughter cells into external tormagen cells (tr cells), or internal multidendritic neurons (MD cells). One of its role in the development of the ESO lineage is to modulate the activity of Notch and PAX2 signals.
messages: Was named 'hamlet' because of its 'to be or not to be' role in ESOP cells differentiation.

7227:Dmel CG4761
gene id: 7227:Dmel_CG4761
uniprot id: A0A0S0WNG8
uniprot id: P13054
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Nucleus

7227:Dmel CG33860
gene id: 7227:Dmel_CG33860
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG8239
gene id: 7227:Dmel_CG8239
uniprot id: Q9VXQ3
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

7227:Dmel CG31613
gene id: 7227:Dmel_CG31613
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG13833
gene id: 7227:Dmel_CG13833
uniprot id: Q9VCS2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7227:Dmel CG7485
gene id: 7227:Dmel_CG7485
uniprot id: E1JI27
uniprot id: P22270
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Preferentially expressed in Drosophila heads.
messages: Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.

7227:Dmel CG5869
gene id: 7227:Dmel_CG5869
uniprot id: Q9VJL6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: In ovaries, expressed in follicular epithelium, in polar cells, migrating border cells, and centripedal cells (at protein level).
messages: Inhibits Arp2/3-mediated actin nucleation (PubMed:25308079). Together with flr, promotes Arp2/3-nucleated actin filament array disassembly (PubMed:25308079). Promotes debranching (PubMed:25308079). Regulates lamellipodial protrusion dynamics possibly by facilitating lamellipodial retraction (PubMed:25308079). In egg chambers, enhances the retraction dynamics of cellular extensions in border cells and thus together with flr plays an important role in directional migration of border cell clusters (PubMed:25308079).
messages: Nucleus
messages: RNAi-mediated knockdown results in not severe delays of border cell migrations in stage 10 egg chambers (PubMed:25308079). Simultaneous RNAi-mediated knockdown of GMF and flr results in an accumulation of F-actin in follicular epithelium of developing egg chambers, border cell migration delays, and in deformation of bristles in the thorax (PubMed:25308079). Simultaneous RNAi-mediated knockdown in border cells of GMF and flr enhances the accumulation of F-actin foci (PubMed:25308079).
messages: cell cortex
messages: lamellipodium
messages: perinuclear region

7227:Dmel CG13410
gene id: 7227:Dmel_CG13410
uniprot id: Q8MS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

7227:Dmel CG32498
gene id: 7227:Dmel_CG32498
uniprot id: E2QD73
uniprot id: H8F4P8
uniprot id: M9PDN2
uniprot id: P12252
uniprot id: Q8IRU4
uniprot id: Q9W4S9
uniprot id: Q9W4T4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory (By similarity).
messages: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory.
messages: Monomer.
messages: Produced by alternative initiation at Met-429 of isoform II.

7227:Dmel CG13221
gene id: 7227:Dmel_CG13221
uniprot id: A0A0B4KEJ4
uniprot id: Q9V3C1
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VHL family.
messages: Expressed throughout development. During embryogenesis specifically expressed in developing tracheal regions.
messages: Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation.
messages: Part of a complex with Cul2, Roc1a/Rbx1 and the elongin BC complex. Interacts with sima/Hif1a. Interacts with itself. Interacts with mgr and betaTub56D/tubulin beta-1 chain. Interacts with tubulin alpha-beta heterodimers by itself or in complex with mgr. Interacts with microtubules (MTs).

7227:Dmel CG9518
gene id: 7227:Dmel_CG9518
uniprot id: Q9VY08
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG9257
gene id: 7227:Dmel_CG9257
uniprot id: Q9VIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG5730
gene id: 7227:Dmel_CG5730
uniprot id: A0A0B4KH34
uniprot id: P22464
names: Developmental Stage
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Expressed throughout development with highest expression seen in adults.

7227:Dmel CG9887
gene id: 7227:Dmel_CG9887
uniprot id: Q9VQC0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG3739
gene id: 7227:Dmel_CG3739
uniprot id: Q9VDX5
names: Similarity
messages: Belongs to the peptidase S28 family.

7227:Dmel CG32549
gene id: 7227:Dmel_CG32549
uniprot id: Q7KUW2
uniprot id: Q9VWV2
uniprot id: Q9VWV4
uniprot id: Q9VWV5
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7227:Dmel CG8468
gene id: 7227:Dmel_CG8468
uniprot id: Q7K1L4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7470
gene id: 7227:Dmel_CG7470
uniprot id: Q9VNW6
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

7227:Dmel CG18428
gene id: 7227:Dmel_CG18428
uniprot id: Q4V5H0
uniprot id: Q9VCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

7227:Dmel CG6167
gene id: 7227:Dmel_CG6167
uniprot id: Q86PF5
uniprot id: Q8SY07
uniprot id: X2JDZ1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

7227:Dmel CG18315
gene id: 7227:Dmel_CG18315
uniprot id: P12426
uniprot id: X2J8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

7227:Dmel CG6404
gene id: 7227:Dmel_CG6404
uniprot id: Q9Y171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

7227:Dmel CG1968
gene id: 7227:Dmel_CG1968
uniprot id: Q9V564
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi function.

7227:Dmel CG31017
gene id: 7227:Dmel_CG31017
uniprot id: Q961I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG10308
gene id: 7227:Dmel_CG10308
uniprot id: Q95U62
uniprot id: Q9VZP3
names: Similarity
messages: Belongs to the cyclin family.

7227:Dmel CG15081
gene id: 7227:Dmel_CG15081
uniprot id: A8DYI6
uniprot id: A8DYI7
uniprot id: Q0E924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

7227:Dmel CG15897
gene id: 7227:Dmel_CG15897
uniprot id: G2J611
uniprot id: Q9W415
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat TRM82 family.
messages: Duplication of 82 nt that changes the frame.
messages: Forms a heterodimer with the catalytic subunit.
messages: In testis, it is present at high level in hub cells, a niche for germline stem cells of testis.
messages: Male sterile and female semi-sterile phenotypes. In males, spermatogenesis is arrested at the elongating stage of the developing spermatids, resulting in an absence of mature sperms in the seminal vesicles. The decreased fertility in females is mostly due to defects in oogenesis. There are abnormal egg chambers present in the mutant females, in which the cystocytes fail to arrest their cell division at the fourth mitotic cycle, resulting in more than 16 cells in a single egg chamber. Additionally, these abnormal cystocytes do not undergo multiple rounds of endoreplication as the nurse cells do in a normal egg chamber.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
messages: Wuho means 'no progeny' in Chinese.

7227:Dmel CG18188
gene id: 7227:Dmel_CG18188
uniprot id: Q7KHI6
names: Similarity
messages: Belongs to the peptidase C14A family.

7227:Dmel CG16979
gene id: 7227:Dmel_CG16979
uniprot id: Q9VUR0
names: Function
names: Similarity
messages: Belongs to the peptidase C78 family.
messages: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.

7227:Dmel CG13424
gene id: 7227:Dmel_CG13424
uniprot id: Q8MZ02
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7364
gene id: 7227:Dmel_CG7364
uniprot id: Q9V3N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

7227:Dmel CG1179
gene id: 7227:Dmel_CG1179
uniprot id: D3PFG8
uniprot id: Q08694
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Found in the midgut.
messages: Maximal expression is found during the third larval instar, it drops to become undetectable in the late pupal stage. The expression in adults is similar to that of first and second larval instars.
messages: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.

7227:Dmel CG4421
gene id: 7227:Dmel_CG4421
uniprot id: Q9VG92
names: Similarity
messages: Belongs to the GST superfamily.

7227:Dmel CG5813
gene id: 7227:Dmel_CG5813
uniprot id: Q9NK54
names: Developmental Stage
names: Function
messages: Expressed both maternally and zygotically.
messages: May be involved in initiation of DNA replication; activation of the chorion gene origins. May have a role in eye and thoracic bristle development.

7227:Dmel CG14909
gene id: 7227:Dmel_CG14909
uniprot id: Q9VEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7227:Dmel CG12055
gene id: 7227:Dmel_CG12055
uniprot id: P07486
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Expressed during adult stages.
messages: Homotetramer.

7227:Dmel CG33242
gene id: 7227:Dmel_CG33242
uniprot id: Q7KV18
names: Similarity
messages: Belongs to the casein kinase 2 subunit beta family.

7227:Dmel CG11937
gene id: 7227:Dmel_CG11937
uniprot id: Q24049
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Enriched expression in the embryonic and larval nervous systems. Strongly expressed in two large neurons that project over all the lobes of the mushroom bodies.
messages: Increased growth of the perineurial glial layer of the larval peripheral nerve.
messages: Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve.
messages: Secreted

7227:Dmel CG4326
gene id: 7227:Dmel_CG4326
uniprot id: Q9W199
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

7227:Dmel CG17888
gene id: 7227:Dmel_CG17888
uniprot id: M9PBV3
uniprot id: M9PEP3
uniprot id: M9PEX4
uniprot id: Q24217
uniprot id: Q5U8V5
uniprot id: Q7KKI2
uniprot id: Q8IQ98
uniprot id: Q8IQ99
uniprot id: Q8SZT1
uniprot id: Q9TVQ4
uniprot id: Q9TW49
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG43775
gene id: 7227:Dmel_CG43775
uniprot id: Q8IRK1
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG14680
gene id: 7227:Dmel_CG14680
uniprot id: Q9VGZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion membrane

7227:Dmel CG30104
gene id: 7227:Dmel_CG30104
uniprot id: Q8SZY4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

7227:Dmel CG1765
gene id: 7227:Dmel_CG1765
uniprot id: A4UZ51
uniprot id: E1JGY2
uniprot id: P34021
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer of USP and ECR (PubMed:8247157). Only the heterodimer is capable of high-affinity binding to ecdysone (PubMed:8247157). Interacts with trr in an ecdysone-dependent manner (PubMed:14603321). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
messages: In the salivary glands of mid instar larvae levels increase during puff stage 1 at 86-94 hours of development then remain relatively constant until the premetamorphic pulse of ecdysone in late larvae. Levels diminish dramatically from puff stage 7 onwards. Levels increase in the prepupal period during puff stage 13-14, the level remains stable until stage 21. A decrease in levels at puff stage 7 is also seen in the Malpighian tubules and less dramatically in the fat body and gut. In the wing disk the relatively low level remains unchanged.
messages: Isoform B1 predominates over isoform A in larval tissues, imaginal histoblast nests and midgut islands. Isoform A predominates over B1 in imaginal disks, and the larval prothoracic gland.
messages: Nucleus
messages: RNAi-mediated knockdown blocks ecdysone-dependent fat body cell migration into the pupal head.
messages: Receptor for ecdysone (PubMed:1913820, PubMed:30293839). Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839).

7227:Dmel CG5717
gene id: 7227:Dmel_CG5717
uniprot id: Q9W029
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG9244
gene id: 7227:Dmel_CG9244
uniprot id: Q9VIE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

7227:Dmel CG6149
gene id: 7227:Dmel_CG6149
uniprot id: Q9VTI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

7227:Dmel CG43324
gene id: 7227:Dmel_CG43324
uniprot id: A0A0B4K838
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7227:Dmel CG6284
gene id: 7227:Dmel_CG6284
uniprot id: Q9VH08
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sirtuin family. Class IV subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Causes lethality during development (PubMed:17159295). Induced silencing shortens life span (PubMed:17159295).
messages: Chromosome
messages: NAD-dependent histone deacylase that acts as a regulator of life span.
messages: Nucleus
messages: Overexpression in flies produces robust lifespan extension in both sexes.
messages: Widely expressed.

7227:Dmel CG11347
gene id: 7227:Dmel_CG11347
uniprot id: A8JNK7
uniprot id: M9NFM7
uniprot id: Q8IRB4
uniprot id: Q9VZC7
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

7227:Dmel CG12241
gene id: 7227:Dmel_CG12241
uniprot id: Q9VFB6
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

7227:Dmel CG10814
gene id: 7227:Dmel_CG10814
uniprot id: Q7K4A8
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

7227:Dmel CG10888
gene id: 7227:Dmel_CG10888
uniprot id: P04950
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells.
messages: Membrane
messages: Opsin Rh3 is sensitive to UV light.
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7227:Dmel CG4220
gene id: 7227:Dmel_CG4220
uniprot id: Q9VJS8
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Elbow/Noc family.
messages: Expressed in tracheal pit cells from stage 11. At stage 12, expression becomes restricted to lateral anterior and posterior tracheal branches. Expressed in the highly proliferative region of the eye-head primordium. Expressed in the distal regions of leg and wing imaginal disks.
messages: May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development.
messages: Self-associates. Interacts with gro and noc.

7227:Dmel CG17947
gene id: 7227:Dmel_CG17947
uniprot id: P35220
uniprot id: X2JBG9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Interacts with arm/armadillo protein.
messages: Membrane
messages: Mutants die at a late embryonic stage with severe defects in head morphogenesis (PubMed:25653389). In embryos, RNAi-mediated knockdown in the hemocytes has no effect on their developmental migration during stages 10-14 of embryogenesis (PubMed:25739458).
messages: Present at all stages, but reached the highest levels during early to mid-embryogenesis.
messages: Rapidly phosphorylated by CK2 and more slowly by CK1.
messages: adherens junction
messages: cytoskeleton

7227:Dmel CG34399
gene id: 7227:Dmel_CG34399
uniprot id: A0A0B4LFI7
uniprot id: A8DWJ8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9862
gene id: 7227:Dmel_CG9862
uniprot id: Q9W2E7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat rae1 family.
messages: Chromosome
messages: Cytoplasm
messages: Head (at protein level).
messages: Interacts with hiw; the interaction with Rae1 may protect hiw from autophagy-mediated degradation (PubMed:21874015). Interacts with Nup98-96 (PubMed:21874015, PubMed:28554770).
messages: Larval brain (at protein level).
messages: Larval lethal (PubMed:27494403). Larvae die at the third-instar stage (PubMed:27494403). RNAi-mediated knockdown in the testes results in male sterility likely due to defects in primary spermatocyte nuclear integrity, meiotic chromosome condensation, segregation, and spindle morphology (PubMed:23788425). These defects lead to a failure to complete meiosis but several aspects of spermatid differentiation can still proceed, including axoneme formation and elongation (PubMed:23788425). RNAi-mediated knockdown in the developing wing or in the proliferating cells of the developing eye, reduces their organ size (PubMed:27494403). RNAi-mediated knockdown in larval neuroblasts results in chromatin undercondensation in metaphase chromosomes (PubMed:23788425). RNAi-mediated knockdown in differentiating eye cells does not result in an obvious phenotype (PubMed:27494403).
messages: Nucleus
messages: Nucleus envelope
messages: Probable component of the nuclear pore complex (NPC) which regulates the nuclear export of specific mRNAs and promotes cell cycle progression during mitosis and male meiosis (PubMed:23788425, PubMed:14729268, PubMed:27494403). Acts with Nup98-96 to promote the nuclear export of specific mRNAs such as Moe, however it does not appear to be required for general nuclear mRNA transport (PubMed:14729268, PubMed:28554770). Essential mitotic and male meiotic cell cycle regulator with roles in many aspects of the cell cycle including chromatin organization and condensation, spindle assembly, chromosome segregation, and maintaining nuclear structure (PubMed:23788425, PubMed:14729268, PubMed:27494403). During male meiosis it is required for completion of meiosis I, as well as accurate cytokinesis of the secondary spermatocytes, and postmeiotic differentiation of spermatids (PubMed:23788425). Acts as a downstream regulatory target of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway to promote mitotic cell cycle progression and proliferation during wing and eye development, and thereby plays a key role in integrating the regulation of proliferation with organ size control (PubMed:27494403, PubMed:14729268). When the Hippo/SWH signaling pathway is inactive, Rae1 acts independently of yki to increase organ size by promoting mitotic S-phase entry and increase cellular proliferation (PubMed:27494403). When the Hippo/SWH signaling pathway is active it inhibits the activity of Rae1 in a Wts-dependent manner to restrict organ growth (PubMed:27494403). However, Rae1 is also able to negatively regulate the levels and activity of yki likely by activating the core kinases of the Hippo/SWH signaling pathway hpo and Wts and increasing the protein levels of hpo, Mer and Wts; it is therefore likely that it functions as part of a negative feedback loop with the Hippo/SWH signaling pathway to regulate pathway homeostasis and prevent organ overgrowth (PubMed:27494403). Promotes mitotic cell cycle pr…
messages: perinuclear region

7227:Dmel CG5177
gene id: 7227:Dmel_CG5177
uniprot id: Q9VM18
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

7227:Dmel CG11063
gene id: 7227:Dmel_CG11063
uniprot id: Q9VY77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zyxin/ajuba family.
messages: Interacts with sav and wts.
messages: Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway.
messages: adherens junction

7227:Dmel CG10052
gene id: 7227:Dmel_CG10052
uniprot id: Q9W2Q1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to function in brain development.
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed in the procephalic region and in the clypeolabrum from stage 8 on and later in the brain and the central nervous system.
messages: Nucleus

7227:Dmel CG16857
gene id: 7227:Dmel_CG16857
uniprot id: Q9U4G1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: During the mid-pupal stage, strongly expressed in the lamina, medulla and inner optic lobe of the developing eye. Specifically detected in R7 and R8 axonal terminals in the medulla.
messages: In the developing eye, has a role in axonal targeting of the R7 photoreceptor where it functions together with tutl. Probably mediates homotypic cell adhesion; the effect is inhibited by Lar.
messages: In the eye, axonal targeting of the R1-R6, R7 and R8 cells appears to be normal. Double knockouts of bdl and tutl rescue the R7 axonal tiling defect of tutl mutants. Double knockouts of bdl and Lar partly rescue the R7 axonal targeting defect of Lar mutants.
messages: In the visual system, expressed in lamina and medulla (at protein level).
messages: Interacts with tutl.
messages: axon

7227:Dmel CG7615
gene id: 7227:Dmel_CG7615
uniprot id: Q9VAH4
names: Developmental Stage
names: Similarity
messages: Belongs to the PP2C family.
messages: Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low.

7227:Dmel CG8290
gene id: 7227:Dmel_CG8290
uniprot id: A0A0B4LEU5
uniprot id: A1Z8R2
uniprot id: Q961B8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG9005
gene id: 7227:Dmel_CG9005
uniprot id: Q7JXG9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ATOS family.
messages: Expressed in macrophages.
messages: Maternally deposited and expressed in the mesoderm, including the region in which macrophages are specified during stage 4-6. Further up-regulated in macrophages starting phase 7 while its expression decreases in the remaining mesoderm. Remains expressed during stage 9-12 in macrophages.
messages: Nucleus
messages: The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes.
messages: Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues. Required in macrophages for their early invasion into the extended germband. Induces transcriptional expression of metabolic enzymes as well as of the translational regulator pths/DDX47. With pths/DDX47, adjusts transcription and translation of a subset of OXPHOS genes to increase mitochondrial bioenergetics and allow macrophage tissue invasion.

7227:Dmel CG1171
gene id: 7227:Dmel_CG1171
uniprot id: P61855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKH/HRTH/RPCH family.
messages: Probably causes a marked increase in hemolymph carbohydrate.
messages: Secreted

7227:Dmel CG10315
gene id: 7227:Dmel_CG10315
uniprot id: Q0E8X6
uniprot id: Q9W1Q8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

7227:Dmel CG7147
gene id: 7227:Dmel_CG7147
uniprot id: A8DZ02
uniprot id: A8DZ03
uniprot id: Q59DZ3
uniprot id: Q9VJW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG16935
gene id: 7227:Dmel_CG16935
uniprot id: Q9V6U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.
messages: Homodimer.
messages: Mitochondrion

7227:Dmel CG3564
gene id: 7227:Dmel_CG3564
uniprot id: Q9W4K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

7227:Dmel CG3315
gene id: 7227:Dmel_CG3315
uniprot id: Q8IFW4
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the thioredoxin family.
messages: Chromosome
messages: Not expressed maternally.
messages: Nucleus
messages: Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.
messages: Testis specific. Not expressed in the embryo. Becomes progressively more strongly expressed during larval and pupal development. In testis, it is strongly expressed in young spermatocytes, and postmeiotic spermatid stages, then expression decreases at the nuclear elongation stage. Strongly expressed in the waste bag, in which material no longer needed for the mature sperm is eliminated. Not expressed in the stem cells and spermatogonial cells.
messages: The TrxT gene, which encodes an testis specific thioredoxin, is adjacent to the dhd gene and shares some regulatory region with it.

7227:Dmel CG6259
gene id: 7227:Dmel_CG6259
uniprot id: M9PCV9
uniprot id: Q9VVI9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome membrane
messages: Homozygous lethal. RNAi-mediated knockdown in ovarian follicle epithelium results in cell proliferation in the germarium epithelium. Stalks between adjacent egg chambers/ follicles become elongated due to increased number of cells and the linear arrangement of germline cysts is also disturbed.
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch endocytosis (PubMed:24762813).
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).

7227:Dmel CG7185
gene id: 7227:Dmel_CG7185
uniprot id: M9NF33
uniprot id: Q9VSH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: May play a role in pre-mRNA 3'-processing.
messages: Nucleus

7227:Dmel CG9677
gene id: 7227:Dmel_CG9677
uniprot id: O77410
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (PubMed:18493598). In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation (PubMed:18493598, PubMed:28505193). During mitosis required for regulating mitotic microtubule growth and kinetochore formation, and consequently is required for satisfying the spindle assembly checkpoint (SAC) during metaphase to prevent delays in mitotic progression (PubMed:28505193). This is likely by promoting the ubiquitination and degradation of Klp67A, a kinesin-like protein that suppresses microtubule polymerization at plus ends (PubMed:28505193). Acts in the COP9 signalosome (CSN) mediated regulation of cullin neddylation by promoting Cul1 and Cul3 neddylation and negatively regulating the CSN complex subunit CSN5 (PubMed:18493598).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Expressed throughout development and in adults (at protein level). Expression peaks in early embryos (2 h after oviposition), then steadily decreases over the embryonic and larval stages (at protein level). Expression increases again 5 days after oviposition and remains stable until day 10 (at protein level).
messages: Expression levels in females and males are relatively similar 10 days after oviposition, however by day 15 expression is higher in gravid females than in males (at protein level).
messages: Homozygous lethal at the first instar larval stage. Larvae are smaller than wild-type and die 3-4 days after hatching.
messages: Microsome

7227:Dmel CG4803
gene id: 7227:Dmel_CG4803
uniprot id: Q9VCV0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

7227:Dmel CG5288
gene id: 7227:Dmel_CG5288
uniprot id: Q95U34
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

7227:Dmel CG11727
gene id: 7227:Dmel_CG11727
uniprot id: Q9VYY9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endosome
messages: Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge.
messages: Interacts with Rab11.

7227:Dmel CG1250
gene id: 7227:Dmel_CG1250
uniprot id: A0A0B4K5Z8
uniprot id: A0A0B4K6T4
uniprot id: Q9VNF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG8038
gene id: 7227:Dmel_CG8038
uniprot id: Q9VSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

7227:Dmel CG3024
gene id: 7227:Dmel_CG3024
uniprot id: F6JQA6
uniprot id: O77277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen
messages: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.

7227:Dmel CG1320
gene id: 7227:Dmel_CG1320
uniprot id: M9PE14
uniprot id: Q9W021
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG4797
gene id: 7227:Dmel_CG4797
uniprot id: Q8MLQ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7227:Dmel CG3812
gene id: 7227:Dmel_CG3812
uniprot id: Q9VYJ4
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

7227:Dmel CG7484
gene id: 7227:Dmel_CG7484
uniprot id: Q9VVJ7
names: Similarity
messages: Belongs to the selenoprotein M/F family.

7227:Dmel CG14443
gene id: 7227:Dmel_CG14443
uniprot id: Q9W3Y5
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: Probable ATP-binding RNA helicase.

7227:Dmel CG3556
gene id: 7227:Dmel_CG3556
uniprot id: M9NGQ5
uniprot id: Q9W4K2
names: RNA Editing
names: Subcellular Location Annotation
messages: Partially edited. Target of Adar.
messages: Secreted

7227:Dmel CG2956
gene id: 7227:Dmel_CG2956
uniprot id: P10627
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer. Interacts with akirin (PubMed:22396663).
messages: Embryos fail to form the ventral furrow at gastrulation and lack mesoderm and all internal organs.
messages: Expressed in embryonic abdomen; a single cell ventrally, pairs of cells laterally and three cells dorsally in each hemisegment. In the thorax, there are patches of cells associated with the imaginal disks. During larval development, cells proliferate and, in the abdomen, they form ventral, lateral and dorsal clusters, which are the precursors of the adult abdominal muscles. In the thorax, they form populations of cells in the imaginal disks that correspond to the adepithelial cells.
messages: Expressed throughout development.
messages: Involved in the establishment and dorsoventral patterning of germ layers in the embryo.
messages: Nucleus

7227:Dmel CG4439
gene id: 7227:Dmel_CG4439
uniprot id: Q7K5K9
names: Similarity
messages: Belongs to the peptidase M17 family.

7227:Dmel CG10749
gene id: 7227:Dmel_CG10749
uniprot id: Q9VU29
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

7227:Dmel CG6450
gene id: 7227:Dmel_CG6450
uniprot id: Q8MSS1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus
messages: Interacts with CLIP-190 and spectrin separately.
messages: Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization (PubMed:11076973). Under starvation conditions recruited by ema to developing autophagsosomes where it may function in autophagosome growth (PubMed:22493244).
messages: autophagosome

7227:Dmel CG32090
gene id: 7227:Dmel_CG32090
uniprot id: Q8IQG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane

7227:Dmel CG4912
gene id: 7227:Dmel_CG4912
uniprot id: Q9VL18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

7227:Dmel CG32683
gene id: 7227:Dmel_CG32683
uniprot id: Q9W2V2
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG1119
gene id: 7227:Dmel_CG1119
uniprot id: P35600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 large subunit family.
messages: Interacts with C-terminus of PCNA.
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds to the primer-template junction (By similarity).

7227:Dmel CG33241
gene id: 7227:Dmel_CG33241
uniprot id: Q7KV15
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG16903
gene id: 7227:Dmel_CG16903
uniprot id: Q9W526
names: Similarity
messages: Belongs to the cyclin family.

7227:Dmel CG32699
gene id: 7227:Dmel_CG32699
uniprot id: Q0KHU5
names: Disruption Phenotype
names: Domain
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Acetyltransferase which mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lipid droplet
messages: Partially edited. Target of Adar.
messages: Probable cloning artifact.
messages: RNAi-mediated knockdown in larvae increases lipid droplet size and reduces lipid droplet number in fat bodies.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.

7227:Dmel CG2191
gene id: 7227:Dmel_CG2191
uniprot id: Q9V9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG13392
gene id: 7227:Dmel_CG13392
uniprot id: Q9VLM7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG12019
gene id: 7227:Dmel_CG12019
uniprot id: C4IY07
uniprot id: Q24276
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC37 family.
messages: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis.
messages: Cytoplasm
messages: Forms a complex with Hsp90. Interacts with a number of kinases such as Cdk1, sev and aurB.

7227:Dmel CG30375
gene id: 7227:Dmel_CG30375
uniprot id: A1Z7D1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7530
gene id: 7227:Dmel_CG7530
uniprot id: A0A0B4KGP3
uniprot id: Q9VFG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7227:Dmel CG15896
gene id: 7227:Dmel_CG15896
uniprot id: Q9W413
names: Similarity
messages: Belongs to the PPR family. P subfamily.

7227:Dmel CG5931
gene id: 7227:Dmel_CG5931
uniprot id: Q9VUV9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (By similarity). Plays a role in pre-mRNA splicing (By similarity).
messages: Composed of two similar domains.
messages: Nucleus

7227:Dmel CG17689
gene id: 7227:Dmel_CG17689
uniprot id: Q2PDX8
uniprot id: Q9VU86
names: Similarity
messages: Belongs to the SPT20 family.

7227:Dmel CG10580
gene id: 7227:Dmel_CG10580
uniprot id: Q24342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 31 family.
messages: Expressed in dorsal cells.
messages: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.
messages: Golgi apparatus membrane

7227:Dmel CG9698
gene id: 7227:Dmel_CG9698
uniprot id: Q9VA60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG8681
gene id: 7227:Dmel_CG8681
uniprot id: Q0E8N6
uniprot id: Q9VIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG10952
gene id: 7227:Dmel_CG10952
uniprot id: M9MSA6
uniprot id: M9MSD1
uniprot id: M9PH56
uniprot id: M9PHM3
uniprot id: M9PHT2
uniprot id: Q02280
uniprot id: Q0KHS8
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Eag sub-subfamily.
messages: Expressed in the axon and the terminal boutons of motor neurons.
messages: Increased growth of the perineurial glial layer of the larval peripheral nerve. Hyperexcitability at the larval neuromuscular junction (NMJ) and memory formation defects in the adult.
messages: Membrane
messages: Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.
messages: The segment H5 is thought to line the channel pore.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: The voltage-dependent potassium channel is a heterotetramer of potassium channel proteins (By similarity). Interaction with CASK.
messages: When in complex with CASK, the efficiency of Thr-787 phosphorylation is increased.

7227:Dmel CG42283
gene id: 7227:Dmel_CG42283
uniprot id: B7Z0Q2
uniprot id: Q8IMU3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

7227:Dmel CG10528
gene id: 7227:Dmel_CG10528
uniprot id: Q9VIR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

7227:Dmel CG43122
gene id: 7227:Dmel_CG43122
uniprot id: Q9U1H0
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the central region of embryos. Also expressed in ovarian follicle cells, the wing imaginal disks and the wing pouch.
messages: Expressed maternally in stage 1-3 blastoderm embryos.
messages: Interacts with gro.
messages: Nucleus
messages: Subject to local inactivation by the RAS-RAF-MAPK signal transduction pathway, which leads to relief of target gene repression. This pathway may be locally activated by a variety of ligands and receptor tyrosine kinases (RTKs) according to the developmental stage and tissue. In terminal patterning, activation of tor by the locally processed ligand trk may promote cic inactivation specifically at the embryonic terminal poles. In the developing wing, activation of Egfr by vn may lead to cic inactivation specifically in prospective vein tissue.
messages: Transcriptional repressor required for the specification of numerous cell types during embryonic development. Required for terminal patterning of early embryos. May associate with gro to repress tll and hkb, restricting their expression to embryonic terminal poles where they initiate correct development of head and tail structures. Required for dorsoventral patterning of oocytes and early embryos. Cooperates with dl to repress zen and other dorsal specific genes within the embryo and promotes expression of the ventralizing factor pip in ovarian follicle cells. Required during wing development for the specification of intervein areas, where it mediates localized repression of vein specific genes such as aos, dpp and vvl.

7227:Dmel CG4118
gene id: 7227:Dmel_CG4118
uniprot id: M9PI81
uniprot id: Q9VV73
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: Expressed in female gonads (at protein level) (PubMed:31219034, PubMed:31570835, PubMed:31368590, PubMed:31384064). Expressed ubiquitously (PubMed:11780633).
messages: Expressed throughout embryonic development.
messages: In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). Interacts (via TAP-C domain) with Panx (via NIR region); the interaction is direct (PubMed:31570835, PubMed:31219034, PubMed:31368590). Interacts (via NTF2 domain) with Nxt1; the interaction is direct and prevents Nxt1 binding to nucleoporins (PubMed:31368590). Interacts with sbr/Nxf1 (PubMed:31570835).
messages: May be involved in the export of mRNA from the nucleus to the cytoplasm (PubMed:11780633). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci (PubMed:31368590, PubMed:31570835, PubMed:31384064). Does not affect piRNA biogenesis (PubMed:31384064). The interaction with Panx stabilizes the nuclear protein complex (PubMed:31384064). Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports (PubMed:31570835, PubMed:31384064).
messages: Nucleus
messages: Results in sterility where fewer eggs are laid and none reach larval stage (PubMed:31219034, PubMed:31384064). Increases transposon expression (PubMed:31219034, PubMed:31384064). RNAi-mediated knockdown in the germline does not affect ovary morphology but results in severe fertility defects where eggs are laied but do not hatch (PubMed:31368590). RNAi-mediated knockdown in the germline increases transposon expression and impairs Panx localization in nurse cells by reducing its stability (PubMed:31219034, PubMed:31570835, PubMed:31368590, PubMed:31384064).
messages: The RNA-binding domain is a non-canonical RNP-type domain.
messages: The TAP-C domain (also known as UBA domain) mediates the interaction with Panx.
messages: nucleoplasm

7227:Dmel CG18319
gene id: 7227:Dmel_CG18319
uniprot id: E1JJN1
uniprot id: P35128
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.
messages: Mutants in this gene exhibit several, largely neuronal defects including lesions affecting the neuronal connectivity of the giant fiber with the 'jumping muscle', and the axons of photoreceptor cells R7 and R8 fail to make the proper right-angle turn into the medulla (hence the term 'bendless').

7227:Dmel CG12537
gene id: 7227:Dmel_CG12537
uniprot id: Q9VFP2
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tdpoz family.
messages: By hh during segmentation.
messages: Expressed maternally in stage 1 embryos. Isoform 1 and isoform 4 are expressed zygotically in stage 4 in pole cells. By stage 8, expressed in 14 segmentally repeating stripes. During stage 9 and 10, expression appears in neuroblasts. After stage 14, expression is restricted to clypeolabrum, anal plate and salivary glands.
messages: Expressed near the anterio-posterior compartment boundary of antenna, leg and wing disks.
messages: Interacts with ci and gft/CUL3.
messages: Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array.
messages: Nucleus
messages: The BTB (POZ) domain interacts with gft/CUL3.
messages: The MATH domain interacts with ci.

7227:Dmel CG15398
gene id: 7227:Dmel_CG15398
uniprot id: Q9VQE8
names: Similarity
messages: Belongs to the TBP family.

7227:Dmel CG10018
gene id: 7227:Dmel_CG10018
uniprot id: Q9VND2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

7227:Dmel CG12292
gene id: 7227:Dmel_CG12292
uniprot id: M9PD12
uniprot id: Q9VK62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

7227:Dmel CG9454
gene id: 7227:Dmel_CG9454
uniprot id: A0A0B4KF64
uniprot id: A1Z6R3
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG12664
gene id: 7227:Dmel_CG12664
uniprot id: Q9GNL3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed strongly throughout the yolk. Later, zygotic expression is confined to the presumptive neurogenic regions. In the CNS, expressed in the ventral nerve cord. Expressed in the PNS including in the lateral chordotonal organs at stages 16-17, expressed in epidermal cells at stages 13-15, and expressed in heart cells at stages 13-17.
messages: Homozygotes are viable and fertile, display no obvious abnormalities in the development of the CNS, PNS or muscles. However, they exhibit highly specific defects in the innervation pattern of muscle 12, but no obvious defects in the innervation of other muscles. Both loss and gain of function mutants display altered neuromuscular specificity.
messages: Involved in the normal targeting of ventral muscle, muscle 12, by motoneurons. May function as an axon guidance molecule involved in neuromuscular specificity.
messages: Membrane

7227:Dmel CG15537
gene id: 7227:Dmel_CG15537
uniprot id: Q9VA76
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG13879
gene id: 7227:Dmel_CG13879
uniprot id: Q9W0S8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:19289792). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:19289792). wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation (PubMed:19289792). It is required for microtubule assembly near spindle poles in oocytes (PubMed:23785300). It is also required for acentrosomal microtubule nucleation and meiotic spindle formation during male meiosis (PubMed:24829288). wac binds to microtubules in vitro (PubMed:19289792).
messages: Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:19289792, PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules (PubMed:19289792). wac interacts directly (via coiled coil) with dgt2 (PubMed:19289792).
messages: Expressed at high levels in early embryos but at low levels in larva, pupa and adult (at protein level).
messages: In adult females, detected only in the abdomen with no expression in the head or thorax (at protein level).
messages: Mutants are viable but have greatly reduced levels of augmin complex subunit Dgt2 (PubMed:19289792). Mitotic progression is delayed but is not blocked before anaphase onset and chromosomes are properly segregated (PubMed:19289792). 7% of meiotic chromosomes in spermatids are missegregated (PubMed:19289792). Mutant males are fertile but mutant females are sterile, developing fully mature ovaries but laying eggs that fail to hatch (PubMed:19289792). Chromosome positioning and segregation are disrupted in oocytes (PubMed:19289792). Chromosome spreading in oocytes following nuclear envelope breakdown is not limited as in wild-type and instead is spread along the spindle axis (PubMed:23785300). Significant increase in the frequency of oocyte spindles with a missing or weak spindle pole (PubMed:23785300). Delayed spindle formation in spermatocytes during male meiosis (PubMed:24829288).
messages: spindle
messages: spindle pole

7227:Dmel CG33840
gene id: 7227:Dmel_CG33840
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG2937
gene id: 7227:Dmel_CG2937
uniprot id: Q8MSS7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

7227:Dmel CG9614
gene id: 7227:Dmel_CG9614
uniprot id: Q86BJ3
names: Developmental Stage
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 3 family.
messages: Down-regulated by gurken (grk) and EGF receptor signaling, preventing its expression in dorsal follicle cells.
messages: Expressed from stage 12 embryos and continues throughout development. Isoform 4 is expressed from stage 14 in the somatic component of the embryonic ovary.
messages: Golgi apparatus membrane
messages: Interacts directly with windbeutel (wbl).
messages: Intron retention.
messages: Isoform 4 is ovary-specific. Isoform 4 and isoform 5 are specifically expressed in the ventral follicle cells of the egg chamber.
messages: Sulfotransferase involved in dorsoventral axis patterning in early embryos. Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell. Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade.

7227:Dmel CG9427
gene id: 7227:Dmel_CG9427
uniprot id: A0A0B4KFH9
uniprot id: Q9VHA5
names: Similarity
messages: Belongs to the GILT family.

7227:Dmel CG18135
gene id: 7227:Dmel_CG18135
uniprot id: M9PI96
uniprot id: Q86BI9
uniprot id: Q86BJ0
uniprot id: Q9VVV5
uniprot id: Q9VVV6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7227:Dmel CG33706
gene id: 7227:Dmel_CG33706
uniprot id: P82701
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection. Detected within 24 hours of infection.
messages: Hemolymph (at protein level).
messages: Not induced after bacterial challenge in strains carrying a loss-of-function mutation for Toll. Constitutively expressed in Toll gain-of-function mutants.
messages: Secreted

7227:Dmel CG6977
gene id: 7227:Dmel_CG6977
uniprot id: Q9VGG5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

7227:Dmel CG1410
gene id: 7227:Dmel_CG1410
uniprot id: Q9VRH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

7227:Dmel CG5794
gene id: 7227:Dmel_CG5794
uniprot id: A0A0B4KHF3
uniprot id: A0A0B4KI06
uniprot id: A0A0B4LIK5
uniprot id: Q8IMW2
uniprot id: Q9VC56
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Interacts with Myc and ago.
messages: Nucleus
messages: RNAi-mediated knockdown is pupal lethal (PubMed:24173801). RNAi-mediated knockdown in the dorsal part of the larval wing disk results in adult wings displaying an upward curvature possibly due to cells on the dorsal side being relatively smaller than cells on the ventral side (PubMed:24173801). RNAi-mediated knockdown in the fat body results in the activation of the Imd and Toll signaling pathways under unchallenged conditions, with constitutive expression of Toll (Drs, IM1) and Imd (DptA, Def, Atta) antimicrobial peptides (PubMed:25027767). Flies infected with E.coli display enhanced expression of Atta compared to controls, whereas expression levels of DptA and Def are decreased (PubMed:25027767). Flies infected with M.luteus display increased expression of Drs, IM1 and also Atta 3 h after infection, whereas 24 h after infection increased expression is only maintained in Atta and IM1 (PubMed:25027767). Double knockdown with imd prevents the enhanced expression of Atta and DptA in uninfected and infected flies (PubMed:25027767).
messages: The name 'Puffyeye' derives from its role in regulating the Myc-dependent rough eye phenotype.
messages: Ubiquitin hydrolase that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:24173801). Essential for Myc-mediated cell growth and proliferation in developing eyes and wings (PubMed:24173801). In the wing and eye, the deubiquitinating activity acts as an antagonist to the SCF E3 ubiquitin-protein ligase member archipelago (ago) to regulate Myc and CycE stability and thus control cell growth and proliferation (PubMed:24173801). Also appears to regulate ago by modulating its induction by Myc (PubMed:24173801). May also promote cell apoptosis in the wing imaginal disk, acting in an apoptotic pathway that appears to be largely independent of Myc (PubMed:24173801). Required for preventing the activation of the immune deficiency (Imd) and Toll signaling cascades under unchallenged conditions (PubMed:25027767). Also appears to be involved in modulating the differential expression of certain antimicrobial peptides (AMP) in response to infection by either Gram-positive or Gram-negative bacteria (PubMed:25027767).

7227:Dmel CG3308
gene id: 7227:Dmel_CG3308
uniprot id: Q9VDC1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

7227:Dmel CG8186
gene id: 7227:Dmel_CG8186
uniprot id: Q9V7D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

7227:Dmel CG4536
gene id: 7227:Dmel_CG4536
uniprot id: Q9W3W0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG42281
gene id: 7227:Dmel_CG42281
uniprot id: M9PCT7
uniprot id: Q24522
uniprot id: Q24523
uniprot id: X2J847
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Anterior dorsal follicle cells at stages 10-12 of oogenesis.
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Cytoplasm
messages: Nucleus
messages: Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages.

7227:Dmel CG7865
gene id: 7227:Dmel_CG7865
uniprot id: Q7KRR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).

7227:Dmel CG7966
gene id: 7227:Dmel_CG7966
uniprot id: Q9VFZ4
names: Similarity
messages: Belongs to the selenium-binding protein family.

7227:Dmel CG9459
gene id: 7227:Dmel_CG9459
uniprot id: Q4V3H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG6370
gene id: 7227:Dmel_CG6370
uniprot id: A0A0B4LFR4
uniprot id: Q7K110
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7227:Dmel CG3702
gene id: 7227:Dmel_CG3702
uniprot id: Q9VQX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

7227:Dmel CG34183
gene id: 7227:Dmel_CG34183
uniprot id: A0A1B2AL60
uniprot id: A8DYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

7227:Dmel CG14543
gene id: 7227:Dmel_CG14543
uniprot id: Q9VBI0
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

7227:Dmel CG32593
gene id: 7227:Dmel_CG32593
uniprot id: A4V4F2
uniprot id: C9QP31
uniprot id: E1JJL2
uniprot id: F2FB46
uniprot id: M9PHL7
uniprot id: M9PHT0
uniprot id: M9PJN2
uniprot id: O61492
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Heterooligomeric complex of flotillins 1 and 2.
messages: May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function.
messages: Membrane

7227:Dmel CG3524
gene id: 7227:Dmel_CG3524
uniprot id: M9PB21
uniprot id: Q9VQL6
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

7227:Dmel CG11318
gene id: 7227:Dmel_CG11318
uniprot id: Q8SZ78
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11132
gene id: 7227:Dmel_CG11132
uniprot id: Q7K3D8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with Rel. Interacts with akirin and Bap55.
messages: Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses (PubMed:24947515). Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel (PubMed:24947515). Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling (PubMed:24947515).
messages: Nucleus
messages: RNAi-mediated knockdown is larval or pupal lethal. RNAi-mediated knockdown in adults results in reduced expression of the antimicrobial peptide genes DptA and Dro in response to septic injury with Gram-negative bacteria E.coli. Adults infected with the Gram-positive bacteria M.luteus display increased expression of the antimicrobial peptide gene Drs.

7227:Dmel CG3593
gene id: 7227:Dmel_CG3593
uniprot id: Q01637
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

7227:Dmel CG7673
gene id: 7227:Dmel_CG7673
uniprot id: P27779
names: Function
names: Miscellaneous
names: Tissue Specificity
messages: Component of the cuticle of the pupa of fruit fly.
messages: Imaginal (anterior) epidermis.
messages: The sequence shown is from genomic DNA.

7227:Dmel CG7989
gene id: 7227:Dmel_CG7989
uniprot id: Q9V7P1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat UTP18 family.
messages: Component of U3 snoRNP complex.
messages: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function.
messages: Induces premature differentiation of germline stem cells (GSCs).
messages: nucleolus

7227:Dmel CG14034
gene id: 7227:Dmel_CG14034
uniprot id: Q0E8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG3368
gene id: 7227:Dmel_CG3368
uniprot id: Q9VB48
names: Similarity
messages: Belongs to the THADA family.

7227:Dmel CG31121
gene id: 7227:Dmel_CG31121
uniprot id: Q0KI14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG5479
gene id: 7227:Dmel_CG5479
uniprot id: Q9W1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

7227:Dmel CG6133
gene id: 7227:Dmel_CG6133
uniprot id: Q9W4M9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
messages: Expressed maternally and zygotically. Expressed during embryonic development.
messages: RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory.
messages: Ubiquitously expressed during embryonic development. Some enrichment is observed in the proventriculus area of the foregut and in the hindgut.
messages: nucleolus

7227:Dmel CG10958
gene id: 7227:Dmel_CG10958
uniprot id: Q9W3J8
names: Similarity
messages: Belongs to the DRC1 family.

7227:Dmel CG32089
gene id: 7227:Dmel_CG32089
uniprot id: Q9VTI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane

7227:Dmel CG11735
gene id: 7227:Dmel_CG11735
uniprot id: Q9VHQ7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to 2-heptanone, amyl acetate, and butyl acetate.
messages: Residues 146 to 150 play a role in odorant (2-heptanone) activation.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG10326
gene id: 7227:Dmel_CG10326
uniprot id: Q9VES1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6ip family.
messages: Membrane

7227:Dmel CG18124
gene id: 7227:Dmel_CG18124
uniprot id: Q9V3F3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mTERF family.
messages: Expressed throughout embryogenesis.
messages: Mitochondrion
messages: RNAi-mediated knockdown is lethal. Most mutants fail to develop past the L3 larval stage, and the few pupal escapers do not develop to the late pupal stages. Mitochondrial DNA (mtDNA) copy number fails to increase during larval development and instead steadily decreases. Increase in broken mTDNA replication intermediates.
messages: Transcription termination factor (PubMed:12626700, PubMed:15845400, PubMed:16648357). Binds promoter DNA and regulates mitochondrial replication and transcription (PubMed:12626700, PubMed:15845400, PubMed:16648357, PubMed:24068965). Transcription termination activity may be polarized with highest termination activity occurring when its DNA-binding site is positioned in the reverse orientation with respect to the incoming RNA polymerase (PubMed:15845400). Required for normal topology and maintenance of mitochondrial DNA (mtDNA) levels (PubMed:24068965). Regulates mtDNA replication by promoting replication pausing, possibly by acting as a natural barrier to replication fork progression (PubMed:24068965). Its function in replication pausing prevents unregulated replication that may occur for example by collisions between the machineries of DNA replication and transcription during mtDNA synthesis (PubMed:24068965). This ensures the incorporation of RNA transcripts into replication intermediates at the replication fork and allow for proper fork progression (PubMed:24068965). Shares mtDNA binding sites with the mitochondrial termination factor mTerf5 and thereby may antagonize mTerf5 function during replication to regulate pausing (PubMed:22784680, PubMed:24068965). Likely to function downstream of Dref which activates genes involved in mtDNA replication and maintenance (PubMed:19032147, PubMed:24068965).

7227:Dmel CG9990
gene id: 7227:Dmel_CG9990
uniprot id: A0A0B4JD13
uniprot id: A0A0B4K7B3
uniprot id: A0A0B4KHS4
uniprot id: B9EQW2
uniprot id: Q8IMM1
uniprot id: Q9VAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG7007
gene id: 7227:Dmel_CG7007
uniprot id: Q9VFE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

7227:Dmel CG33162
gene id: 7227:Dmel_CG33162
uniprot id: Q9VSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG10609
gene id: 7227:Dmel_CG10609
uniprot id: Q9VNB5
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.
messages: Cell membrane
messages: Expressed throughout all developmental stages. First expressed at embryonic stage 15. Pupal expression first occurs 80 hours after puparium formation.
messages: Expression is restricted to olfactory sensory neurons (OSNs). Coexpressed with Snmp in a lateral-distal population of OSNs. Expressed in the embryonic antennal-maxillary complex, in all 21 OSNs of the larval dorsal organ, in the pupal antennal OSNs, in all 120 adult maxillary palp neurons and in approximately 70-80% of adult antennal OSNs, where expression is highest at the dorsal-medial edge. Localized to OSN cell bodies and to the distal portion of ciliated OSN dendrites.
messages: Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. The homomeric Orco channel is thought to be a cyclic-nucleotide-gated ion channel that depolarizes the olfactory receptor neuron.

7227:Dmel CG5493
gene id: 7227:Dmel_CG5493
uniprot id: A1ZBA8
names: Cofactor
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.

7227:Dmel CG3161
gene id: 7227:Dmel_CG3161
uniprot id: P23380
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Expressed in the larval middle mid-gut; predominantly in the copper cell region with lower levels of expression in the interstitial cells.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32269334). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334).
messages: RNAi-mediated knockdown specifically in pHCl-2 expressing enterocytes delays pupariation (PubMed:32269334). Knockdown in the intestinal copper cell region decreases intestinal acidity (PubMed:32269334).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

7227:Dmel CG9998
gene id: 7227:Dmel_CG9998
uniprot id: M9NDZ4
uniprot id: M9NF89
uniprot id: M9NH51
uniprot id: Q24562
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Forms a heterodimer with the U2AF small subunit.
messages: Necessary for the splicing of pre-mRNA.
messages: Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
messages: Nucleus
messages: Present throughout development.

7227:Dmel CG10338
gene id: 7227:Dmel_CG10338
uniprot id: Q9VJ63
names: Similarity
messages: Belongs to the RUS1 family.

7227:Dmel CG12363
gene id: 7227:Dmel_CG12363
uniprot id: A0A1B2AIX7
uniprot id: Q94524
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex.
messages: Belongs to the dynein light chain Tctex-type family.
messages: Male sterility.
messages: The cytoplasmic dynein complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
messages: cytoskeleton

7227:Dmel CG3073
gene id: 7227:Dmel_CG3073
uniprot id: Q9W501
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

7227:Dmel CG32476
gene id: 7227:Dmel_CG32476
uniprot id: Q8SYV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG33817
gene id: 7227:Dmel_CG33817
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG6906
gene id: 7227:Dmel_CG6906
uniprot id: M9PF87
uniprot id: Q9VTU8
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

7227:Dmel CG15283
gene id: 7227:Dmel_CG15283
uniprot id: Q9VJS6
names: Similarity
messages: Belongs to the SDHAF4 family.

7227:Dmel CG33247
gene id: 7227:Dmel_CG33247
uniprot id: Q7KV23
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG6556
gene id: 7227:Dmel_CG6556
uniprot id: Q7KNQ9
names: Similarity
messages: Belongs to the CNKSR family.

7227:Dmel CG10890
gene id: 7227:Dmel_CG10890
uniprot id: Q4U2Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

7227:Dmel CG13163
gene id: 7227:Dmel_CG13163
uniprot id: Q4V619
names: Similarity
messages: Belongs to the IF-3 family.

7227:Dmel CG44128
gene id: 7227:Dmel_CG44128
uniprot id: B5X0J6
uniprot id: Q9V9J3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Following epithelial wounding, no migration of macrophages to wound sites (PubMed:26028435). RNAi-mediated knockdown in glial cells potently suppresses glial phagocytic activity with drpr not recruited to severed maxillary palp axons, blockage of glial hypertrophy, blockage of drpr up-regulation after antennal ablation and reduced clearance of severed axons in the central nervous system (PubMed:18432193).
messages: In early embryos expression is very low, expression increases during embryogenesis. Also expressed in larvae and pupae.
messages: Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834).
messages: Ubiquitous in early embryos, in stages 13-16 expression is seen in visceral mesoderm, hindgut, brain, anal pads and ventral ganglions. In larvae, expression is in CNS, wing disk, leg disk and photoreceptor precursors in the eye-antenna disks posterior to the morphogenetic furrow.

7227:Dmel CG3621
gene id: 7227:Dmel_CG3621
uniprot id: O97418
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

7227:Dmel CG31672
gene id: 7227:Dmel_CG31672
uniprot id: F0JAI6
names: Disruption Phenotype
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with Eb1 via the two SxIP motifs; the interaction is not required for kebab kinetochore localization.
messages: No visible phenotype. Flies are viable and fertile. RNAi-mediated knockdown does not affect mitotic progression.
messages: kinetochore
messages: perinuclear region
messages: spindle

7227:Dmel CG9131
gene id: 7227:Dmel_CG9131
uniprot id: A4V0A1
uniprot id: Q9V3U9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the slowmo family.
messages: Expressed from stage 16 embryos.
messages: Expressed in specific tissues such as the developing central nervous system (CNS) and both the male and female germline. In the CNS, it is restricted in a subset of cells during embryogenesis and early larval development. In embryos, it is also expressed in salivary glands. In the testis, expressed in somatic cyst cells throughout the distal region where the mitotic cysts develop, extending through to meiotic cysts.
messages: Flies have defects in locomotor behavior and die during larval development, due to abnormal neural function. Mutant males lacking functional slmo survive into adulthood and show an early division of the germline but never progress through the gonial divisions. Mutant females demonstrate germarial degeneration and reduced fertility.
messages: Mitochondrion
messages: Required to regulate peristaltic movement and also for germline proliferation in males and females.

7227:Dmel CG33960
gene id: 7227:Dmel_CG33960
uniprot id: A0A0B4KG38
uniprot id: A1ZAF5
uniprot id: Q29QV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17241
gene id: 7227:Dmel_CG17241
uniprot id: Q9VCS9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG14196
gene id: 7227:Dmel_CG14196
uniprot id: Q9VWK0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG31216
gene id: 7227:Dmel_CG31216
uniprot id: Q9VDU7
names: Similarity
messages: Belongs to the isochorismatase family.

7227:Dmel CG5613
gene id: 7227:Dmel_CG5613
uniprot id: Q86B46
uniprot id: Q9VX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

7227:Dmel CG11525
gene id: 7227:Dmel_CG11525
uniprot id: Q95TJ9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: Chromosome
messages: Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism (PubMed:18667003, PubMed:18286205, PubMed:21311225, PubMed:22976300, PubMed:25995770, PubMed:26274446). Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium (PubMed:18667003, PubMed:18286205). Involved in the transcriptional repression of the homeotic genes Scr and Ubx (PubMed:25995770). Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells (PubMed:23121330, PubMed:22976300). Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism (PubMed:26274446). Required for the formation of bilateral symmetry (PubMed:21998598). Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression (PubMed:21311225).
messages: Expressed throughout all stages of the cell cycle (at protein level) (PubMed:21311225). Expressed throughout development with notably less expression in third instar larva than in embryo or adult (PubMed:18286205).
messages: Interacts with corto (PubMed:18286205). Interacts with the cyclin-dependent kinases Cdk2 and Cdk4 (PubMed:21311225). Interacts with Brca2 and Rad9 (PubMed:22976300). Interacts with polycomb protein Asx (PubMed:25995770). Interacts with protein phosphatase 2A subunit wdb (PubMed:26274446).
messages: Viable but females are sterile and produce eggs with a ventralized phenotype where the dorsal respiratory appendages are fused (PubMed:23121330, PubMed:22976300). Reduced levels of grk protein in the oocyte cytoplasm and very low levels in follicle cells and in the extracellular space separating the oocyte from the follicular epithelium but no effect on grk transcription (PubMed:23121330). Increased incidence of DNA double-strand breaks in mutant germaria (PubMed:22976300). Reduced body size and weight and reduced cell size and number with mutants showing signs of starvation under normal feeding conditions and disturbed fat metabolism marked by elevated levels of stored fat (PubMed:26274446). Reduced phosphorylation levels of Akt1, Thor/4E-BP and S6k (PubMed:26274446). Accumulation of insulin-like peptide Ilp5 in larval brains is reduced to levels comparable to starved control animals (PubMed:26274446).

7227:Dmel CG10802
gene id: 7227:Dmel_CG10802
uniprot id: M9PGD7
uniprot id: Q9W4R9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

7227:Dmel CG5044
gene id: 7227:Dmel_CG5044
uniprot id: Q86BP1
uniprot id: Q960K8
names: Function
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

7227:Dmel CG5637
gene id: 7227:Dmel_CG5637
uniprot id: A0A0B4KGY5
uniprot id: G7H7Y6
uniprot id: P25724
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nanos family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Expressed maternally. Present during oogenesis and early stages of embryogenesis.
messages: Interacts with pum and brat. Acts via the formation of a quaternary complex composed of pum, nos, brat and the 3'-UTR mRNA of hb. Interacts with cup. Binds RNA with no specificity.
messages: Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal. Acts by forming a complex with pum and brat that regulates translation and mRNA stability. The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Controls posterior development. Rescuing factor for the abdominal defect of posterior group mutants. The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein.
messages: Posterior part of the embryo. While the transcript is present throughout the embryo, nos translation is controlled by smg, and the protein is found in pole plasm and pole cells.
messages: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. The presence of the zinc molecules is essential for the translation repression activity of the protein.

7227:Dmel CG4079
gene id: 7227:Dmel_CG4079
uniprot id: G7H801
uniprot id: P49906
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF11 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Taf2 and Taf4.
messages: Nucleus
messages: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

7227:Dmel CG30277
gene id: 7227:Dmel_CG30277
uniprot id: Q9W271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG10436
gene id: 7227:Dmel_CG10436
uniprot id: P54191
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PBP/GOBP family.
messages: Expressed in the antenna, mostly on the anterior surface of the third antennal segment (PubMed:7545907, PubMed:29630598). Expressed in auxilary cells and the third antennal segment and exported to the sensillar lymph (at protein level) (PubMed:29630598).
messages: Expression is inversely regulated in male and female in response to the male-specific pheromone cis-vaccenyl acetate (cVA) and is dependent on the active neurotransmission of cVA-sensitive neurons to second order olfactory neurons.
messages: Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male-specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively.
messages: RNAi-mediated knockdown in males results in reduction of aggressive display. RNAi-mediated knockdown in females results in a significant reduction in sexual receptivity after exposure to the male-specific pheromone cis-vaccenyl acetate (cVA).
messages: Secreted

7227:Dmel CG4215
gene id: 7227:Dmel_CG4215
uniprot id: M9ND86
uniprot id: P43248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Heterodimer of Msh2/Spel and Msh6.
messages: Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).
messages: Nucleus

7227:Dmel CG8540
gene id: 7227:Dmel_CG8540
uniprot id: Q9VS78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG15093
gene id: 7227:Dmel_CG15093
uniprot id: A0A0B4JCU8
uniprot id: Q9V8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
messages: Mitochondrion

7227:Dmel CG17654
gene id: 7227:Dmel_CG17654
uniprot id: E1JHR5
uniprot id: P15007
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

7227:Dmel CG2665
gene id: 7227:Dmel_CG2665
uniprot id: Q23982
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Protein component of the posterior mating plug.
messages: Secreted
messages: Specifically expressed in the ejaculatory bulb and seminal fluid.

7227:Dmel CG32256
gene id: 7227:Dmel_CG32256
uniprot id: H0RNL7
uniprot id: P83295
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: Membrane
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.
messages: Plays a role in the sugar gustatory response.

7227:Dmel CG6353
gene id: 7227:Dmel_CG6353
uniprot id: H0RNK8
uniprot id: Q9VD92
names: Function
names: Similarity
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (CG9987).

7227:Dmel CG6225
gene id: 7227:Dmel_CG6225
uniprot id: Q9VG44
names: Similarity
messages: Belongs to the peptidase M24B family.

7227:Dmel CG13396
gene id: 7227:Dmel_CG13396
uniprot id: M9PCK4
uniprot id: O16868
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fuzzy family.
messages: Cytoplasm
messages: Expressed at low levels at all stages of development, with a peak of expression in the embryo and in the 2-day-old pupa. Detected in all wing cells of the 2-day-old pupa.
messages: Expressed in female, but not male.
messages: Plays a role in the organization of cell polarity via a planar cell polarity (PCP) cascade. Involved in the development of the hairs on the wings. Specify the correct orientation of the hair by limiting the site of prehair initiation to the distal vertex of the wing cells. Controls wing cell hair number by maintaining the integrity of the cytoskeletal components that direct hair development.
messages: cytoskeleton

7227:Dmel CG7655
gene id: 7227:Dmel_CG7655
uniprot id: Q9VEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Nucleus inner membrane

7227:Dmel CG9552
gene id: 7227:Dmel_CG9552
uniprot id: O44252
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. High level of zygotic expression is seen in embryos from stage 12 onwards and in adults.
messages: Expressed in cells of the somatic mesoderm, most notably the muscle founder cells, between embryonic stages 12 and 14, in growing muscle fibers in dorsal, lateral and ventral positions. At stage 16 strongest expression is in some ventral muscles and muscle 8. At stages 16/17 expression is restricted to some cells of the CNS, the brain and the gonads.
messages: Flies exhibit diminished fusion of embryonic myoblasts to syncytial myotubes.
messages: May have a central role in the fusion process during myogenesis, within the somatic mesoderm.
messages: Membrane

7227:Dmel CG14017
gene id: 7227:Dmel_CG14017
uniprot id: Q9VMP5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

7227:Dmel CG5683
gene id: 7227:Dmel_CG5683
uniprot id: P39413
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Found in all tissues examined including the ovary and the fat body.
messages: Higher levels are found in third-instar larvae and in adults.
messages: Nucleus
messages: Transcriptional repressor that binds specifically to fat body-specific enhancers, namely the adult ADH enhancer (AAE) and the enhancer that controls yolk protein gene expression.

7227:Dmel CG15361
gene id: 7227:Dmel_CG15361
uniprot id: Q9VQ66
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG16718
gene id: 7227:Dmel_CG16718
uniprot id: A0A0B4JCY1
uniprot id: A0A0B4KGH4
uniprot id: Q8IN71
uniprot id: Q9VDV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG3897
gene id: 7227:Dmel_CG3897
uniprot id: Q8IQQ6
uniprot id: Q8IQQ7
uniprot id: Q9VVG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG14523
gene id: 7227:Dmel_CG14523
uniprot id: Q9VAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG5250
gene id: 7227:Dmel_CG5250
uniprot id: Q9VDY7
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

7227:Dmel CG6895
gene id: 7227:Dmel_CG6895
uniprot id: A0ZX68
uniprot id: Q9NHB0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insect beta-1,3-glucan binding protein family.
messages: Cell membrane
messages: Expressed at moderate levels throughout the life cycle.
messages: Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria (PubMed:10827089). Upon recognition of invading microorganism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin (PubMed:10827089, PubMed:16399077).

7227:Dmel CG9553
gene id: 7227:Dmel_CG9553
uniprot id: M9NEU5
uniprot id: P25843
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. This profilin is required for intercellular cytoplasm transport during Drosophila oogenesis.
messages: Expressed in ovary and head.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

7227:Dmel CG32858
gene id: 7227:Dmel_CG32858
uniprot id: A4V441
uniprot id: Q24524
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an actin bundling protein (PubMed:1723709, PubMed:19729655). May have a role in the asymmetric organization and/or movement of cytoplasmic components (PubMed:1723709). It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis (PubMed:1723709, PubMed:19729655).
messages: Belongs to the fascin family.
messages: Interacts with Rab35, with stronger binding to the Rab35-GTP form compared to the Rab35-GDP form.
messages: cytoskeleton

7227:Dmel CG45785
gene id: 7227:Dmel_CG45785
uniprot id: A8Y5B7
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG18031
gene id: 7227:Dmel_CG18031
uniprot id: Q9W508
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG13201
gene id: 7227:Dmel_CG13201
uniprot id: Q7KBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 29 family.
messages: Component of the Mediator complex (By similarity). Self-associates. Interacts with dsx.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for female somatic sexual development.
messages: Nucleus

7227:Dmel CG2368
gene id: 7227:Dmel_CG2368
uniprot id: A0A126GUM1
uniprot id: A1Z8A4
uniprot id: A1Z8A6
uniprot id: A4UZC9
uniprot id: Q0E9C8
uniprot id: Q7K0T7
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG14080
gene id: 7227:Dmel_CG14080
uniprot id: M9PFW0
uniprot id: M9PG13
uniprot id: Q9VVW5
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activity abolished by tyrosine phosphatase inhibitor sodium vanadate. Activated by rl.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Homozygous embryonic lethal, while hypomorphic alleles (reduction in gene dosage) lead to extra photoreceptor cells in the eye, ectopic veins in wings and severe defects in oogenesis in females. Females with the germ line mutation lay only a small number of eggs. The laid eggs are abnormal, approximately 77% of the laid eggs are shorter and some display severe defects in chorion formation. These embryos could not escape the embryonic stage and progress beyond the two-nuclei stage. Null mutants are viable and fertile exhibiting a mild, but significant increase in wing vein material. They are slightly rough eyed. Null mutation affects the R3 and R4 photoreceptors with a low penetrance resulting in either the loss of one cell of the R3/R4 pair or in the misdifferentiation of these photoreceptors. R3 and R4 are often symmetrically arranged in the eye in opposite to the asymmetrical positions they adopt in wild-type ommatidium. Ommatidia of the null mutants often contain a mystery cell having differentiated as a photoreceptor. Null mutants also exhibit mild delay in tracheal branching. Delay in 12% dorsal branches (DBs) compared with 0.3% in wild-type between metameres 4 to 8 that have reached the dorsal midline at stage 14-15. Null mutants have defects in cell intercalation.
messages: Interacts (via N-terminal region) with phosphorylated rl.
messages: Low expression in the various developmental stages, although relatively high levels detected in 8 to 12 h embryos, as well as in pupae and adults, particularly in the head region. Expressed in third-instar eye imaginal disks posterior to the morphogenetic furrow where photoreceptor differentiation occurs. Preferentially detected in wing imaginal disks in two stripes of cells interrupted at the dorsoventral boundary, which correspond to the developing veins L3 and L4. In pupal wings the maximal levels of expression are present in all longitudinal veins, with low levels detected in most intervein cells. Uniformly distributed in the syncytial blastoderm (stage 4). At early stage 5, accumulates at the embryonic poles and is absent from the central region. This pattern evolves very rapidly with the formation of a third central domain of expression from 85% to 40% egg length. In older embryos, the main places where high levels accumulate correspond to the invaginating mesoderm, the tracheal pits at stage 11, the visceral mesoderm at stage 13, the heart, the midline and the apodema. Expression in tracheal branches at later stages.
messages: Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.
messages: Ubiquitous expression in eye and wing imaginal disks. Enriched in ovary.

7227:Dmel CG8532
gene id: 7227:Dmel_CG8532
uniprot id: A8JNM3
uniprot id: M9PBU6
uniprot id: M9PEF2
uniprot id: M9PEM7
uniprot id: Q7KU90
uniprot id: Q7KU93
uniprot id: Q9VS85
names: Similarity
messages: Belongs to the epsin family.

7227:Dmel CG10572
gene id: 7227:Dmel_CG10572
uniprot id: Q9VT57
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.
messages: Expressed both maternally and zygotically during developmental periods of maximal cell division; most abundant in early embryos and low levels in larvae, pupae and adults.
messages: Nucleus

7227:Dmel CG13608
gene id: 7227:Dmel_CG13608
uniprot id: A0A1B2AKB3
uniprot id: Q9VCC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7227:Dmel CG33198
gene id: 7227:Dmel_CG33198
uniprot id: A0A0B4LFM5
uniprot id: Q86BE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PEN-2 family.
messages: Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
messages: Membrane

7227:Dmel CG8049
gene id: 7227:Dmel_CG8049
uniprot id: M9PCD8
uniprot id: M9PCX8
uniprot id: P08630
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expressed both maternally and zygotically. Predominantly in early to middle embryogenesis, in larvae and adult females.
messages: Flies exhibit shortened copulatory duration (due to incomplete fusion of the left and right halves of the apodeme that holds the penis during copulation) and reduced adult-stage life span.
messages: Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.
messages: Ring canals in the egg chambers and imaginal disks of third-instar larvae.

7227:Dmel CG2938
gene id: 7227:Dmel_CG2938
uniprot id: Q9W4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

7227:Dmel CG10702
gene id: 7227:Dmel_CG10702
uniprot id: Q9VJ04
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1728
gene id: 7227:Dmel_CG1728
uniprot id: Q9Y1A3
uniprot id: X2JB87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of Tim8 and 3 copies of Tim13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of Tim22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The Tim8-Tim13 complex mediates the import of some proteins while the predominant Tim9-Tim10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of Tim8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

7227:Dmel CG3109
gene id: 7227:Dmel_CG3109
uniprot id: Q9W547
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

7227:Dmel CG8891
gene id: 7227:Dmel_CG8891
uniprot id: Q9VMW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

7227:Dmel CG33895
gene id: 7227:Dmel_CG33895
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG6210
gene id: 7227:Dmel_CG6210
uniprot id: Q95ST2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.
messages: Belongs to the wntless family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Expressed both maternally and zygotically throughout development.
messages: Golgi apparatus membrane
messages: Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Segment polarity phenotype (cuticles are smaller and lack the alternate naked regions) and wing margin defects (a reduced number of posterior wing-margin bristles and the even bristles distribution is interrupted). Heterozygotes die as pharate adults with appendage malformations, such as lack of arista and antennal segments, rudimentary legs and wing-to-notum transformations.
messages: Ubiquitously expressed in the wing imaginal disk, increased expression is observed in a stripe at the dorso-ventral boundary and other regions of the wing disk that express wg. Also expresses in the leg imaginal disk. During larval development, expression is seen in both motorneurons and muscle.

7227:Dmel CG12245
gene id: 7227:Dmel_CG12245
uniprot id: M9PFC8
uniprot id: Q27403
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed transiently in early glial cells.
messages: Flies exhibit failure of glia to differentiate in the CNS and in the PNS, glia are transformed into neurons. Ectopic expression causes neurons to transform to glia.
messages: Nucleus
messages: Transcription factor that induces gliogenesis. It determines the choice between glial and neuronal fates. Also has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes.

7227:Dmel CG33889
gene id: 7227:Dmel_CG33889
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG8362
gene id: 7227:Dmel_CG8362
uniprot id: Q9VH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

7227:Dmel CG17061
gene id: 7227:Dmel_CG17061
uniprot id: M9ND17
uniprot id: M9NEX4
uniprot id: M9PGK2
uniprot id: Q9W0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG13426
gene id: 7227:Dmel_CG13426
uniprot id: A1ZBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG4321
gene id: 7227:Dmel_CG4321
uniprot id: Q9VS79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG10373
gene id: 7227:Dmel_CG10373
uniprot id: Q9VJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

7227:Dmel CG9210
gene id: 7227:Dmel_CG9210
uniprot id: M9PEP2
uniprot id: Q9VXU0
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

7227:Dmel CG3712
gene id: 7227:Dmel_CG3712
uniprot id: Q9W4L1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL33 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG42574
gene id: 7227:Dmel_CG42574
uniprot id: A0A0B4JCV6
uniprot id: A0A0B4JCW5
uniprot id: A0A0B4JD62
uniprot id: A0A0B4JDA1
uniprot id: A0A0B4JDB5
uniprot id: A0A0B4LGQ5
uniprot id: A0A0B4LGR2
uniprot id: A0A0B4LHQ4
uniprot id: Q9VN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: nucleoplasm

7227:Dmel CG10858
gene id: 7227:Dmel_CG10858
uniprot id: Q9VZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG10535
gene id: 7227:Dmel_CG10535
uniprot id: A0A0B4KFR6
uniprot id: A0A0B4KGU0
uniprot id: Q9VGK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Homodimer. Component of the elongator complex.
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7227:Dmel CG15531
gene id: 7227:Dmel_CG15531
uniprot id: Q9VA93
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG11387
gene id: 7227:Dmel_CG11387
uniprot id: M9NEA5
uniprot id: M9PGW9
uniprot id: P10180
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.
messages: Belongs to the CUT homeobox family.
messages: Cell-specific pattern of expression. Broadly expressed during embryonic development.
messages: Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.
messages: Nucleus
messages: Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

7227:Dmel CG13123
gene id: 7227:Dmel_CG13123
uniprot id: M9PD20
uniprot id: Q9VL80
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10184
gene id: 7227:Dmel_CG10184
uniprot id: Q9VCK6
names: Similarity
messages: Belongs to the threonine aldolase family.

7227:Dmel CG33145
gene id: 7227:Dmel_CG33145
uniprot id: A1Z8R6
uniprot id: Q7JZU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7227:Dmel CG4497
gene id: 7227:Dmel_CG4497
uniprot id: Q9VM36
names: Similarity
messages: Belongs to the FAM122 family.

7227:Dmel CG17358
gene id: 7227:Dmel_CG17358
uniprot id: A0A0B4KFN0
uniprot id: P49905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF12 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Tbp, Taf2 and Taf4.
messages: Nucleus
messages: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

7227:Dmel CG11963
gene id: 7227:Dmel_CG11963
uniprot id: A0A0B4JCW4
uniprot id: A0A126GUR6
uniprot id: Q95U38
uniprot id: Q9VHJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

7227:Dmel CG5920
gene id: 7227:Dmel_CG5920
uniprot id: M9PB84
uniprot id: P31009
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). Has a specific developmental role during oogenesis (PubMed:7982558).

7227:Dmel CG13550
gene id: 7227:Dmel_CG13550
uniprot id: Q9W1R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ICE1 family.
messages: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).
messages: Component of the little elongation complex (LEC), at least composed of Ell, Eaf, Ice1 and Ice2.
messages: Nucleus

7227:Dmel CG43225
gene id: 7227:Dmel_CG43225
uniprot id: M9PE65
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the brain and parts of the peripheral nervous system (at protein level) (PubMed:10037607). Expressed from embryonic stage 13 in the differentiating nervous system in a subset of glial cells, including longitudinal glia and segmental boundary cells (PubMed:10037607).
messages: May have serine protease inhibitor activity (Probable). Might play a role in the glial-neuronal signaling pathway that is important in establishing the electrical properties of axonal membranes (PubMed:10037607).
messages: Membrane
messages: Temperature-dependent loss of excitatory junctional potentials in the larval neuromuscular junction.
messages: axon

7227:Dmel CG16889
gene id: 7227:Dmel_CG16889
uniprot id: Q9V3R6
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the ADAT1 family.
messages: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.
messages: Expressed both maternally and zygotically.
messages: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
messages: Widely expressed in early embryos, and later concentrates in the central nervous system.

7227:Dmel CG33124
gene id: 7227:Dmel_CG33124
uniprot id: Q9VQ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG11767
gene id: 7227:Dmel_CG11767
uniprot id: P81913
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Not expressed in either the antenna or maxillary palp.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, hexanol, octanol, nonanol, propyl acetate, butyl acetate, isoamyl acetate, methyl caproate, anisole, heptanal, 2-heptanone, r-carvone, and nonanoic acid. Responds also to pyrazines.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG33304
gene id: 7227:Dmel_CG33304
uniprot id: Q76NQ1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Expressed exclusively in the central nervous system of embryos. In the third instar larva, expression is also restricted to neural tissue with specific expression behind the morphogenetic furrow in the developing eye and in the optic lobes within brain.
messages: Flies display a severe decrease in daytime activity pattern and an increase in sleeping periods.
messages: Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.
messages: Specifically expressed in the nervous system and in brain.

7227:Dmel CG3879
gene id: 7227:Dmel_CG3879
uniprot id: Q00449
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Intron retention.
messages: Membrane

7227:Dmel CG6311
gene id: 7227:Dmel_CG6311
uniprot id: C6TP77
uniprot id: Q9VVI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EDC3 family.
messages: Forms a complex with DCP1A, DCP2, Me31B/DDX6 and EDC4/HEDLS (By similarity). Within this complex directly interacts with DCP1A, DCP2 and Me31B/DDX6 (PubMed:17923697, PubMed:18765641, PubMed:19285948). Homooligomer (PubMed:17923697). Interacts with Gyf (PubMed:31114929).
messages: In the process of mRNA degradation, may play a role in mRNA decapping.
messages: P-body

7227:Dmel CG45070
gene id: 7227:Dmel_CG45070
uniprot id: Q9VUL1
uniprot id: X2JCY2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.
messages: Cytoplasm
messages: In ovary, expressed in oocytes, follicle cells and nurse cells. Also expressed in larval and adult testis (at protein level). In larvae, expressed in lymph gland, salivary gland, regions of the midgut, testis, optical lobe and trachea. Isoform 1 is expressed in adult testis, ovary, accessory gland and head. Isoform 2 is weakly expressed in ovary.
messages: Isoform 1 expression is high during embryogenesis, modest during larval and pupal stages and abundant in adult. Isoform 2 is expressed at low levels in 0-4h embryos and at very low levels during the rest of developmental stages and in adult.
messages: Larval lethal.
messages: Required for assembly of cytoophidium in female germline cells (PubMed:23459760, PubMed:25223282). In nurse cells, CTPsyn filament assembly in the cytoophidium is regulated by Ack kinase which may thereby contribute to the control of CTP production at specific stages of oogenesis and development of the nurse cell membrane (PubMed:25223282).

7227:Dmel CG8039
gene id: 7227:Dmel_CG8039
uniprot id: Q9VHN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG8592
gene id: 7227:Dmel_CG8592
uniprot id: P92189
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Essential in the female germline for proper survival, sex determination and differentiation. Participates in the transcriptional activation of Otu. Does not regulate the expression of Ovo.
messages: Germ cells specific. Expressed in all germ cells. During the first instar larvae, it is expressed in all germ cells of both sexes. In third instar larvae, it decreases in male germ cells while it remains in female germ cells. In adult ovary, it is expressed in cells of the germarium, including the stem cells. In the early previtellogenic stages, it is highly expressed in the nurse cells. During vitellogenesis, it is not translocated into the maturing egg. In testes, it is only expressed during some steps of male germline differentiation. At the apex testis, it is expressed at low level in stem cells and dividing spermatogonia, while in newly formed 16-cell cysts of primary spermatocytes, it is transiently but strongly expressed before vanishing during spermatocyte growth phase.
messages: In embryos, it is expressed from stage 11 in the germ cell soon after their migration through the midgut epithelium.
messages: Nucleus

7227:Dmel CG14181
gene id: 7227:Dmel_CG14181
uniprot id: Q9VSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion.

7227:Dmel CG2043
gene id: 7227:Dmel_CG2043
uniprot id: P07188
names: Function
messages: Component of the larval cuticle.

7227:Dmel CG8055
gene id: 7227:Dmel_CG8055
uniprot id: Q8T0Q4
names: Similarity
messages: Belongs to the SNF7 family.

7227:Dmel CG14871
gene id: 7227:Dmel_CG14871
uniprot id: Q4V645
names: Function
names: Subcellular Location Annotation
messages: Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels.
messages: Secreted

7227:Dmel CG9214
gene id: 7227:Dmel_CG9214
uniprot id: A4V4L0
uniprot id: Q6NQY2
uniprot id: Q9VXJ9
names: Similarity
messages: Belongs to the BTG family.

7227:Dmel CG7011
gene id: 7227:Dmel_CG7011
uniprot id: Q9VUM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane

7227:Dmel CG7503
gene id: 7227:Dmel_CG7503
uniprot id: Q01819
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion.
messages: Cell membrane
messages: Embryo.
messages: Predominantly expressed in abdominal and thoracic segment muscle and motorneuron cells.

7227:Dmel CG11833
gene id: 7227:Dmel_CG11833
uniprot id: Q9VAQ9
names: Similarity
messages: Belongs to the strictosidine synthase family.

7227:Dmel CG14480
gene id: 7227:Dmel_CG14480
uniprot id: Q7JWU9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG15356
gene id: 7227:Dmel_CG15356
uniprot id: Q9VQ58
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG14511
gene id: 7227:Dmel_CG14511
uniprot id: Q9VAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

7227:Dmel CG2975
gene id: 7227:Dmel_CG2975
uniprot id: Q9VQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

7227:Dmel CG4723
gene id: 7227:Dmel_CG4723
uniprot id: Q9VCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG6174
gene id: 7227:Dmel_CG6174
uniprot id: P45889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP1 subfamily.
messages: cytoskeleton

7227:Dmel CG5062
gene id: 7227:Dmel_CG5062
uniprot id: Q9W4E4
names: Similarity
messages: Belongs to the CFAP45 family.

7227:Dmel CG7009
gene id: 7227:Dmel_CG7009
uniprot id: Q9VDD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

7227:Dmel CG15161
gene id: 7227:Dmel_CG15161
uniprot id: Q9VJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

7227:Dmel CG2843
gene id: 7227:Dmel_CG2843
uniprot id: Q9VQF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

7227:Dmel CG9344
gene id: 7227:Dmel_CG9344
uniprot id: Q9W2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

7227:Dmel CG10090
gene id: 7227:Dmel_CG10090
uniprot id: Q9VGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50. The complex interacts with the Tim44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

7227:Dmel CG33472
gene id: 7227:Dmel_CG33472
uniprot id: A0A0B4LEU0
uniprot id: B5A5T4
names: Disruption Phenotype
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the quiver family.
messages: Both daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K(+) current.
messages: Cell membrane
messages: Enriched in brain and head.
messages: Membrane
messages: N-glycosylated.
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.
messages: Several sequencing errors.

7227:Dmel CG42576
gene id: 7227:Dmel_CG42576
uniprot id: B7TB45
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: 'Spaetzle' means 'noodles' in German.
messages: Detected in the fan-shaped body which is a component of the locomotion center in the central nervous system (CNS) (at protein level) (PubMed:23892553). Expressed in the optic lobes and brain (PubMed:19018662).
messages: Expressed throughout development (PubMed:19018662). Expressed in the embryonic CNS midline (at protein level) (PubMed:23892553). Also expressed in various longitudinal muscles (at protein level) (PubMed:23892553). In embryos, expressed in the CNS midline and in the muscles (PubMed:19018662). In larvae, expressed in the lamina of the optic lobe (PubMed:19018662). Expressed in larval body wall muscles (PubMed:24124519).
messages: Homodimer; disulfide-linked.
messages: Neurotrophin which may function as a ligand for the Toll-related receptors Toll-7 and Tollo (PubMed:22022271, PubMed:23892553). Binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). In larvae, involved in the negative regulation of the tracheal immune response to bacterial infection perhaps by acting as a ligand for the Toll-related receptor Tollo (PubMed:22022271). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519).

7227:Dmel CG5063
gene id: 7227:Dmel_CG5063
uniprot id: Q9VF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

7227:Dmel CG6555
gene id: 7227:Dmel_CG6555
uniprot id: O46227
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Main cells of accessory gland and seminal fluid.
messages: Responsible for physiological and behavioral changes in mated female flies.
messages: Secreted

7227:Dmel CG11158
gene id: 7227:Dmel_CG11158
uniprot id: Q9I7S2
names: Similarity
messages: Belongs to the IUNH family.

7227:Dmel CG7755
gene id: 7227:Dmel_CG7755
uniprot id: A1ZAD2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

7227:Dmel CG33672
gene id: 7227:Dmel_CG33672
uniprot id: A1Z933
names: Similarity
messages: Belongs to the BolA/IbaG family.

7227:Dmel CG8250
gene id: 7227:Dmel_CG8250
uniprot id: Q7KJ08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG6433
gene id: 7227:Dmel_CG6433
uniprot id: D0IQH1
uniprot id: M9NF69
uniprot id: Q23989
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the villin/gelsolin family.
messages: Germline specific in adult flies.
messages: Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments. Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis.

7227:Dmel CG44154
gene id: 7227:Dmel_CG44154
uniprot id: A0A0B4KEE4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Is required to nuclear migration in eye and to anchor klar in the nuclear membrane (PubMed:18820457).
messages: Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins.
messages: Expressed in all cells in the eye disk.
messages: Homozygous mutant flies live to adulthood and are fertile and exhibit rough and irregular eyes. Flies have an aberrant R-cell rhabdomeres morphology and R-cell and cone cell nuclei are mispositioned.
messages: Membrane
messages: perinuclear region

7227:Dmel CG4097
gene id: 7227:Dmel_CG4097
uniprot id: P40304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

7227:Dmel CG9012
gene id: 7227:Dmel_CG9012
uniprot id: P29742
uniprot id: X2JC31
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (By similarity). Interacts with sau (PubMed:24786584).
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
messages: The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).
messages: coated pit

7227:Dmel CG11148
gene id: 7227:Dmel_CG11148
uniprot id: Q7KQM6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GIGYF family.
messages: Component of the 4EHP-GYF2 complex, composed of at least eIF4EHP and Gyf (PubMed:31114929). Interacts (via N-terminus) with eIF4EHP; interaction is required for eIF4EHP-mediated translational repression and mRNA decay (PubMed:31114929). Interacts (via me31B binding motif) with the decapping activator DDX6/ME31B (via RecA-like domain 2), and also interacts (via GYF domain) with the decapping effector protein Patr-1 (PubMed:31114929, PubMed:31439631). Also interacts with other decapping effector proteins, such as Edc3 and Ge-1 (PubMed:31114929). Interacts with CCR4-NOT deadenylase complex members Not1, Not3, Pop2 and twin, and other components of the deadenylation complexes such as Rga, PAN2 and PAN3 (PubMed:31114929).
messages: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:31114929). In the 4EHP-GYF2 complex, promotes translational repression and decay of mRNA targets by recruiting and bridging the association of the 4EHP complex with decapping effector proteins, such as me31B and Patr-1, and the deadenylation CCR4-NOT complex (PubMed:31114929). Involved in regulating starvation-induced, developmental and physiological autophagy, which is critical for eliminating ubiquitinated proteins and dysfunctional organelles in order to maintain tissue homeostasis (PubMed:26086452).
messages: Larvae and adults display defects in starvation-induced, developmental and physiological autophagy, which result in the accumulation of autophagosomes, autolysosomes, and increased Atg8a expression (PubMed:26086452). Adults display reduced locomotion and decreased life span, likely due to the dysregulation of autophagy which results in the accumulation of ubiquitinated proteins and dysfunctional mitochondria in neuronal and muscle tissues (PubMed:26086452). TORC1 signaling is also inhibited, possibly to compensate for the loss of autophagy (PubMed:26086452).

7227:Dmel CG8338
gene id: 7227:Dmel_CG8338
uniprot id: Q9V6Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7227:Dmel CG5557
gene id: 7227:Dmel_CG5557
uniprot id: Q9VDZ3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Death at larval stage. Larvae display a motility defect whereby the body wall musculature overcontract radially during the peristaltic wave typical of insect larval motility, apparent as a 'squeezing' of intestine.
messages: Interacts with nab; which acts as a coactivator. Interacts with ap.
messages: Largely restricted to subsets of cells in the CNS throughout embryonic and first instar larval (L1) development. Expressed in a population of lateral interneurons, primarily projecting axons in the anterior and posterior commissures. Overlaps with ap within the thoracic ap cluster. By stage 17, it is restricted to 2 neurons within the ap-cluster, with one neuron typically continuing to display higher levels of expression. Selectively expressed at higher levels within the FMRFa Tv neurons. Expressed in all leucokinergic cells.
messages: Nucleus
messages: Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting.

7227:Dmel CG31956
gene id: 7227:Dmel_CG31956
uniprot id: B7Z006
uniprot id: Q8IA42
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Expressed both maternally and zygotically. Expressed during embryonic, larval, pupal and adult stages. Weakly expressed during early embryonic stages but displays a dramatic increase at 12-24 hours of embryonic development. Continues to be in adult but displays much lower levels in the female adult as compared with the male.
messages: Expressed in developing oocytes and egg chambers. During embryonic stages 9-11, expressed in the primordium of the foregut, midgut and hindgut. During embryonic stages 12-13, shows specific expression in the proventriculus that continues until the end of embryogenesis. In third instar larvae, ubiquitously expressed in wing, eye-antennal, leg and haltere imaginal disks.
messages: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the diglycosylated Muc5AC-3/13 as substrate.
messages: Golgi apparatus membrane
messages: Membrane
messages: RNAi-mediated knockdown in the whole body or the digestive system and reproductive tract is lethal (PubMed:22157008). RNAi-mediated knockdowin in hemocytes, epiderm, endoderm, mesoderm, respiratory system or nervous system causes no defect (PubMed:22157008).
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG9361
gene id: 7227:Dmel_CG9361
uniprot id: Q9VHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7227:Dmel CG6904
gene id: 7227:Dmel_CG6904
uniprot id: A0A0B4KHJ5
uniprot id: D5SHR2
uniprot id: Q9VFC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 3 family.
messages: In third instar larvae, isoform B is highly expressed in skeletal muscle but not detected in fat body.
messages: Isoform B interacts with Atg8a upon starvation.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
messages: Transfers the glycosyl residue from UDPG to the non-reducing end of alpha-1,4-glucan. In larval skeletal muscle, isoform B is required for the formation of autophagosomes during starvation and during cloroquine-induced vacuolar myopathy.
messages: autophagosome

7227:Dmel CG3478
gene id: 7227:Dmel_CG3478
uniprot id: Q7KT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG13176
gene id: 7227:Dmel_CG13176
uniprot id: Q7JW27
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization (PubMed:19633175). Participates in both linear- and branched-actin networks (PubMed:19633175). Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis (PubMed:19633175). Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber (PubMed:19633175). During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). Its function in hemocyte transmigration is independent of the WASH complex (PubMed:25739458). May play a role in endosomal sorting; its assembly in the WASH complex may regulate its nucleation-promoting factor (NPF) activity.
messages: Belongs to the WASH1 family.
messages: Component of the WASH complex (PubMed:20498093). Interacts with spir and capu (PubMed:19633175). Interacts (via N-terminus) with Rho1 (via N-terminus) (PubMed:25739458).
messages: Lethal. Larvae die at the transition from third larval instar to prepupal stage.

7227:Dmel CG14028
gene id: 7227:Dmel_CG14028
uniprot id: Q9VMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Membrane

7227:Dmel CG4651
gene id: 7227:Dmel_CG4651
uniprot id: M9PFF0
uniprot id: P41126
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the 60S large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (Probable).
messages: Cytoplasm

7227:Dmel CG1629
gene id: 7227:Dmel_CG1629
uniprot id: Q9V4C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major royal jelly protein family.
messages: Catalyzes the conversion of dopaminechrome to 5,6-dihydroxyindole in the eumelanin biosynthetic pathway originating from dopamine (PubMed:34388859). Catalyzes tautomerization of dopaminechrome to 5,6-dihydroxyindole during eumelanin biosynthesis (PubMed:34388859). Acts both dopaminechrome and N-methyl dopaminechrome but not on dopachrome or other aminochromes tested (PubMed:34388859).
messages: Secreted

7227:Dmel CG4717
gene id: 7227:Dmel_CG4717
uniprot id: P10734
uniprot id: X2JGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Nucleus
messages: Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression.

7227:Dmel CG3988
gene id: 7227:Dmel_CG3988
uniprot id: Q9U6R9
names: Similarity
messages: Belongs to the SNAP family.

7227:Dmel CG12131
gene id: 7227:Dmel_CG12131
uniprot id: A0A0B4LF26
uniprot id: Q7K550
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm

7227:Dmel CG10897
gene id: 7227:Dmel_CG10897
uniprot id: A0A0B4KEM1
uniprot id: A0A0B4KFE3
uniprot id: A1Z8M2
uniprot id: A8DYA3
names: Similarity
messages: Belongs to the WAL family.

7227:Dmel CG1837
gene id: 7227:Dmel_CG1837
uniprot id: Q9VYV3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Expressed in embryo, larva, pupa and adult (at protein level).
messages: Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells (PubMed:19927123, PubMed:23337816). Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation (PubMed:19927123, PubMed:23337816).
messages: Reduced level of apoptotic cell phagocytosis (PubMed:19927123). Loss of both Prtp and CaBP1 does not cause a further decrease in the reduced level of phagocytosis seen in either Prtp-lacking or CaBP1-lacking embryos (PubMed:22158613).

7227:Dmel CG13533
gene id: 7227:Dmel_CG13533
uniprot id: Q9W1X9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Asrij' stands for 'blood' in Sanskrit as this protein is strongly expressed in blood vessels.
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Expressed in all cells of the primary lymph gland lobe.
messages: Interacts with STAT3 and ARF1 (PubMed:24707047).
messages: Maintains stem cell potency (PubMed:24707047). Involved in endocytic pathways that mediate signaling during hematopoiesis (PubMed:24707047, PubMed:22110713).
messages: Marker for all hemocyte lineages during development.

7227:Dmel CG17646
gene id: 7227:Dmel_CG17646
uniprot id: Q8T9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG4839
gene id: 7227:Dmel_CG4839
uniprot id: Q9VL34
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7227:Dmel CG11799
gene id: 7227:Dmel_CG11799
uniprot id: M9PC64
uniprot id: M9PF47
uniprot id: M9PI07
uniprot id: Q0E8F8
uniprot id: Q8IQE9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG34452
gene id: 7227:Dmel_CG34452
uniprot id: A8JNT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

7227:Dmel CG7172
gene id: 7227:Dmel_CG7172
uniprot id: Q9VP13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

7227:Dmel CG31508
gene id: 7227:Dmel_CG31508
uniprot id: A0A1B2AJ59
uniprot id: Q8IN43
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A humoral factor that may play a role in stress tolerance.
messages: Belongs to the Turandot family.
messages: By a variety of stressful conditions including bacterial infection, heat shock and exposure to ultraviolet light.
messages: Expressed in late stage embryos. Disappears by early larval states and reappears in the third larval instar. Subsequently maintained throughout pupal development until adulthood.
messages: Secreted

7227:Dmel CG32708
gene id: 7227:Dmel_CG32708
uniprot id: Q9W394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

7227:Dmel CG16792
gene id: 7227:Dmel_CG16792
uniprot id: Q24297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Interacts with the SMN complex.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

7227:Dmel CG2021
gene id: 7227:Dmel_CG2021
uniprot id: Q9W087
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

7227:Dmel CG9885
gene id: 7227:Dmel_CG9885
uniprot id: P07713
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Expressed in the dorsal region of the embryo, and becomes enriched in a dorsal midline stripe just prior to gastrulation. Expressed in midgut mesoderm and in two overlapping regions of the embryonic large intestine. Expressed in a long-range concentration gradient in the wing imaginal disk.
messages: Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern. Component of a complex composed of dpp, sog and tsg. Interacts with nord and gbb; the interaction interferes with dpp secretion (PubMed:35037619).
messages: In the third-instar larval stage, expressed in a stripe of cells at the anterior-posterior (A/P) compartment boundary of wing cells (at protein level) (PubMed:35609633, PubMed:35037619). In the pupal wing, expression does not change during the first 8 hrs after pupation (AP) but then disappears from the A/P boundary and commences expression in the differentiating longitudinal veins (at protein level) (PubMed:35037619). Expressed both maternally and zygotically (PubMed:10903186). First detected during stages 8 to 10 of oogenesis (PubMed:10903186).
messages: Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
messages: Secreted

7227:Dmel CG10341
gene id: 7227:Dmel_CG10341
uniprot id: A0A023GQ99
uniprot id: Q9VJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAF1 family.
messages: During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Nucleus
messages: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1/CG4038 to yield mature H/ACA snoRNPs complex (By similarity).

7227:Dmel CG31146
gene id: 7227:Dmel_CG31146
uniprot id: Q9VIC7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG6610
gene id: 7227:Dmel_CG6610
uniprot id: Q9VRT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

7227:Dmel CG34455
gene id: 7227:Dmel_CG34455
uniprot id: Q7KUC2
names: Similarity
messages: Belongs to the pyridoxine kinase family.

7227:Dmel CG18468
gene id: 7227:Dmel_CG18468
uniprot id: Q95RV3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG14024
gene id: 7227:Dmel_CG14024
uniprot id: Q9VMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane

7227:Dmel CG40080
gene id: 7227:Dmel_CG40080
uniprot id: P83103
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
messages: Chromosome
messages: Interacts with pds5 and vtd.
messages: Nucleus lamina
messages: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase (PubMed:32750047). Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation (PubMed:32750047). During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity). During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations (PubMed:32750047). Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing (PubMed:32750047).
messages: Viable, however adults display a decrease in survival which is stronger in females than males, and both sexes display a decrease in fertility (PubMed:32750047). Loss of phosphorylation of histone H3 leading to reduced centromeric cohesion (PubMed:32750047). RNAi-mediated knockdown reduces the size of salivary gland nuclei (PubMed:32750047). Also results in a strong decrease in chromosome-bound pds5 in larval salivary glands and a significant decrease in chromatin-bound vtd in mitotic and interphase embryo cells (PubMed:32750047).
messages: spindle

7227:Dmel CG4802
gene id: 7227:Dmel_CG4802
uniprot id: A0A0B4KG54
uniprot id: A0A0B4LFH0
uniprot id: Q9V813
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: In embryos, expressed in the fat body and visceral mesoderm.
messages: No visible auditory phenotype.
messages: Nucleus

7227:Dmel CG4101
gene id: 7227:Dmel_CG4101
uniprot id: A0A1B2AJ70
uniprot id: O77286
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

7227:Dmel CG43756
gene id: 7227:Dmel_CG43756
uniprot id: Q8IPH9
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in head. In larval brain, it is expressed in the mushroom body. Also expressed in larval muscles.
messages: Expressed with a circadian rhythm showing a peak at ZT15 (zeitgeber 15).
messages: Interacts specifically with Slo; which activates Slo activity. Interacts with 14-3-3-zeta when phosphorylated. Forms a heterotetrameric complex containing phosphorylated Slob, Slo and 14-3-3-zeta, which represses Slo activity due to the indirect interaction between Slo and 14-3-3-zeta.
messages: Phosphorylated. Phosphorylation of Ser-54 and Ser-79 is required for the interaction with 14-3-3-zeta but not with that of Slo.
messages: Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively.

7227:Dmel CG34454
gene id: 7227:Dmel_CG34454
uniprot id: A8JNG6
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG9852
gene id: 7227:Dmel_CG9852
uniprot id: P81928
names: Function
names: Subcellular Location Annotation
messages: Essential for viability.
messages: Membrane

7227:Dmel CG31559
gene id: 7227:Dmel_CG31559
uniprot id: Q9VNL4
names: Similarity
messages: Belongs to the GRXCR1 family.

7227:Dmel CG8784
gene id: 7227:Dmel_CG8784
uniprot id: Q9VFW5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG4960
gene id: 7227:Dmel_CG4960
uniprot id: Q9VBM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

7227:Dmel CG10563
gene id: 7227:Dmel_CG10563
uniprot id: Q9VIZ2
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3025
gene id: 7227:Dmel_CG3025
uniprot id: O02193
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-638 is required for binding histone H4 with high affinity and for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Chromosome
messages: Component of the male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3 (PubMed:20620954, PubMed:16543150). Component of the non-specific lethal (NLS) histone acetyltransferase complex at least composed of mof, nls1, dgt1/NSL2, Rcd1/NSL3, Rcd5/MCRS2, MBD-R2 and wds (PubMed:16543150, PubMed:20620954). In males, interacts with nucleoporin Mtor (PubMed:34133927).
messages: Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the male-specific lethal (MSL) complex (PubMed:9155031, PubMed:16543150, PubMed:34133927). Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes (PubMed:9155031). May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex (PubMed:11258702). As part of the nonspecific lethal (NLS) complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification (PubMed:20620954).
messages: Nucleus
messages: RNAi-mediated knockdown in male salivary glands, decreases chromosome X gene expression (PubMed:34133927). Simultaneous RNAi-mediated knockdown of mof with RNAi-mediated knockdown of Mtor in male salivary glands rescues the decrease in chromosome X gene expression (PubMed:34133927).

7227:Dmel CG31670
gene id: 7227:Dmel_CG31670
uniprot id: Q9VQ56
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in immature intermediate neural progenitors (INP) and type II neuroblasts in larval brains (at protein level) (PubMed:24550111, PubMed:27151950, PubMed:27510969, PubMed:28245922). Expressed in lamina L3 neurons from early pupal to adult stages, but is absent in late third instar larvae when lamina neurons begin to differentiate (at protein level) (PubMed:29513217). Expressed in the developing embryonic brain from stage 4 (PubMed:18621688).
messages: Found in a probable chromatin remodeling Brahma-associated proteins (BAP) complex composed of at least brm, Bap60, Snr1 and erm. Within the complex, interacts (via N-terminus) with Bap60 and HDAC3.
messages: Nucleus
messages: Results in abnormal expansion of type II neuroblasts and in ectopic expression of pnt and grh (PubMed:28245922, PubMed:20152183). Simultaneous RNAi-mediated knockdown of N partially restores normal neuroblast numbers and prevents loss of pnt expression (PubMed:27151950). Simultaneous RNAi-mediated knockdown of erm with either HDAC3 or members of the Brm-associated protein (BAP) chromatin-remodeling complex brm and Snr1 further increases the number of type II neuroblasts compared with the single knockdown (PubMed:24618901). Simultaneous RNAi-mediated knockdown of both erm and the ETS protein pnt restores normal neuroblast numbers (PubMed:28899667). RNAi-mediated knockdown in lamina neurons and their precursor cells, results in defective targeting of R8 neurons, with 45% of them terminating in medulla layers other than the correct M3 layer (PubMed:29513217). RNAi-mediated knockdown in L3 neurons, reduces expression of NetB in L3 neurons, L3 somas and the developing M3 layer (PubMed:29513217).
messages: The second, third and fourth zinc finger domains are necessary for repressing gene transcription.
messages: Zinc-finger transcriptional repressor (PubMed:24550111, PubMed:24618901, PubMed:28245922). In larval brain, involved in the maintenance of cell fate of intermediate neural progenitors (INPs) that derive from type II neuroblasts (PubMed:20152183, PubMed:24618901, PubMed:27151950, PubMed:27510969, PubMed:28245922, PubMed:28899667). Restricts INP developmental potential and dedifferentiation by interacting with HDAC3 and the chromatin remodeling Brahma-associated protein (BAP) complex (PubMed:24618901, PubMed:24550111, PubMed:27151950, PubMed:28899667, PubMed:28245922). Restricts INP proliferation by regulating neuroblast specific factors such as prospero, pnt and grh, and by antagonizing the function of self-renewal factors, such as klu, dpn and E(spl)mgamma-HLH (PubMed:20152183, PubMed:24550111, PubMed:28899667). In the optic lobe, essential for coordinating the innervation/ targeting of the L3 and R8 axons to the M3 layer of the medulla (PubMed:29513217). Early in medulla development, functions in parallel to CadN and Sema1a pathways to promote targeting of the L3 growth cones to the proximal domain of the outer medulla possibly by controlling the expression of various cell surface genes such as dpr1 and dpr17 which function in L3 growth cone targeting (PubMed:29513217). Then once L3 growth cones segregate into the developing M3 layer, it activates the expression of netrins NetA and NetB which act locally to promote the attachment of R8 growth cones within the M3 layer (PubMed:29513217).

7227:Dmel CG11567
gene id: 7227:Dmel_CG11567
uniprot id: M9PCQ1
uniprot id: Q27597
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Embryos and adults.
messages: Endoplasmic reticulum membrane
messages: High in antennae.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with sturkopf.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
messages: This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals.

7227:Dmel CG6646
gene id: 7227:Dmel_CG6646
uniprot id: A1Z9J4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Double knockouts for dj-1beta and dj-1alpha is viable but with reduced male fertility (PubMed:16139213, PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha is more sensitive to chemical agents that induce oxidative stress (PubMed:16139213). Double knockouts for dj-1beta and dj-1alpha shows reduced lifespan and decreased spontaneous movement over time (PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha spermatozoa are morphologically normal but immotile with abnormal vacuoles in the Nebenkern, abnormal mitochondria and aberrant separation of investment cones during sperm individualization (PubMed:20457924).
messages: Expressed at high levels only in the later stages of development.
messages: Expressed in testis (at protein level).
messages: Mitochondrion
messages: Nucleus
messages: Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor (PubMed:16139213, PubMed:16139214, PubMed:20457924). Does not play a role in methylglyoxal detoxification (By similarity).

7227:Dmel CG1214
gene id: 7227:Dmel_CG1214
uniprot id: Q9W0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

7227:Dmel CG12954
gene id: 7227:Dmel_CG12954
uniprot id: Q7JZM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG4289
gene id: 7227:Dmel_CG4289
uniprot id: Q9VPB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

7227:Dmel CG32045
gene id: 7227:Dmel_CG32045
uniprot id: Q9VT28
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the furry protein family.
messages: Co-expressed with trc in all da neurons in third instar wild-type larvae; axons and dendritic branches.
messages: Expression is very low in embryonic and early larval stages, increases to be high from third larval instar to adults.
messages: Flies exhibit branched arista laterals, branched bristles and a strong multiple hair cell phenotype that consists of clusters of epidermal hairs and branched hairs. Dendrites of fry and trc mutants display excessive terminal branching. Branched laterals in mutant pupae arista are due to the splitting of individual laterals during elongation and abnormally shaped actin bundles.
messages: Plays a role in the Trc/fry signaling pathway by promoting trc kinase activity (PubMed:11526084, PubMed:15479641, PubMed:32022690). Plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton (PubMed:11526084). Plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (PubMed:15479641). Together with trc, has a role in regulating microtubule-sliding during neurite outgrowth (PubMed:32022690).

7227:Dmel CG3924
gene id: 7227:Dmel_CG3924
uniprot id: O18353
uniprot id: Q7KVG9
names: Similarity
messages: Belongs to the LDB family.

7227:Dmel CG32319
gene id: 7227:Dmel_CG32319
uniprot id: Q8IRH2
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

7227:Dmel CG34415
gene id: 7227:Dmel_CG34415
uniprot id: A8DYH1
uniprot id: Q8MS31
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8665
gene id: 7227:Dmel_CG8665
uniprot id: Q9VIC9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

7227:Dmel CG6081
gene id: 7227:Dmel_CG6081
uniprot id: Q9VMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG17149
gene id: 7227:Dmel_CG17149
uniprot id: B7Z0G7
uniprot id: M9PFR5
uniprot id: Q9VW97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Chromosome
messages: Component of a complex that contains at least HDAC1/Rpd3, CoRest and Su(var)3-3/Hdm.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
messages: Nucleus
messages: Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri-methylated 'Lys-4' of histone H3. May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes.

7227:Dmel CG18773
gene id: 7227:Dmel_CG18773
uniprot id: C0HL62
uniprot id: C0HL63
names: Developmental Stage
names: Function
messages: Component of the cuticle of the larva.
messages: Expression begins at the end of second larval instar, present throughout third larval instar and is gone by the pupal stages.

7227:Dmel CG11608
gene id: 7227:Dmel_CG11608
uniprot id: Q9VG47
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG11261
gene id: 7227:Dmel_CG11261
uniprot id: Q9VU33
names: Similarity
messages: Belongs to the cullin family.

7227:Dmel CG8562
gene id: 7227:Dmel_CG8562
uniprot id: Q9VS66
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG4582
gene id: 7227:Dmel_CG4582
uniprot id: Q9VBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG1532
gene id: 7227:Dmel_CG1532
uniprot id: Q9VRD4
names: Similarity
messages: Belongs to the glyoxalase I family.

7227:Dmel CG2102
gene id: 7227:Dmel_CG2102
uniprot id: Q7M3M8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in a specific subset of neuroblasts in the ventral nerve cord and the procephalic region in the embryo. Expressed in many, if not all, late delaminating NBs, and in early NBs, but only after they have undergone several rounds of ganglion mother cell-producing divisions.
messages: Expressed in embryos. Expressed from blastoderm embryos. Not expressed in first and second instar larvae. Weakly expressed in third instar larvae. May be weakly expressed in adults.
messages: Nucleus
messages: Transcription factor that specifies expression of key genes in developing central nervous system (CNS). Essential for many, if not all, late developing neuroblastoma (NB) sublineages. Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively. Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells. Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes. Controls engrailed (en) expression in the ventral nerve chord.

7227:Dmel CG10352
gene id: 7227:Dmel_CG10352
uniprot id: M9PJJ5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG8331
gene id: 7227:Dmel_CG8331
uniprot id: A0A0B4JD51
uniprot id: A1Z9M2
uniprot id: F2FB55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

7227:Dmel CG33812
gene id: 7227:Dmel_CG33812
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG10920
gene id: 7227:Dmel_CG10920
uniprot id: Q9W3P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG33533
gene id: 7227:Dmel_CG33533
uniprot id: Q59DY5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Detected in adults and larvae.
messages: Galactose-specific lectin that displays calcium-dependent activity (PubMed:16475980, PubMed:17287021). Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization (PubMed:17287021). This is likely by interacting with carbohydrates on the surface of the hemocytes (PubMed:17287021). Also displays agglutination activity against the Gram-negative bacterium E.coli (PubMed:17287021).
messages: Secreted

7227:Dmel CG12972
gene id: 7227:Dmel_CG12972
uniprot id: Q9VP44
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG15676
gene id: 7227:Dmel_CG15676
uniprot id: Q8T965
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7227:Dmel CG15436
gene id: 7227:Dmel_CG15436
uniprot id: Q9VR05
names: Disruption Phenotype
names: Function
names: PTM
names: Subunit
messages: Interacts with park.
messages: Phosphorylated by Pink1 leading to ubiquitination by park.
messages: RNAi-mediated knockdown in dopamine neurons increases dopaminergic mRNA levels of srl and its downstream transcription factors ewg and TFAM, and also results in a significant increase in mean lifespan (64 days) compared to controls (60 days) (PubMed:27819722, PubMed:32138754). However, it has no effect on mitochondrial abundance, neuronal survival or climbing performance (PubMed:32138754). Double knockdown with park or Pink1 in the dopamine neurons, improves climbing performance defects and rescues decreased mRNA levels of srl, ewg and TFAM in the single park or Pink1 mutants (PubMed:32138754). RNAi-mediated knockdown in the eye has no significant effect on ommatidia or bristle number (PubMed:32138754).
messages: Transcription repressor that inhibits transcription of srl/PGC-1-alpha to negatively regulate mitochondrial biogenesis and thereby promotes neurodegeneration (PubMed:27819722, PubMed:32138754). In neurons, functions downstream of the Pink1-park pathway and is likely to act as part of the Pink1-park homeostatic mechanism that maintains mitochondrial quality and function through degradation (mitophagy) and synthesis (biogenesis) (PubMed:32138754).
messages: Ubiquitinated by park. Polyubiquitination by park leads to degradation by the proteasome which likely activates mitochondrial biogenesis to maintain neuron health and function.

7227:Dmel CG10497
gene id: 7227:Dmel_CG10497
uniprot id: A0A0B4K862
uniprot id: A0A0B4LG79
uniprot id: B7YZM9
uniprot id: B7YZN0
uniprot id: E1JGQ9
uniprot id: P49415
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that bears heparan sulfate. Required for axonal and myotube guidance, is a necessary component of slit/robo signaling and is required in the slit target cells.
messages: Cell surface proteoglycan.
messages: Flies exhibit aberrant midline guidance of axons and establishment of muscle pattern.
messages: In 13-16 hours embryos, expressed in lymph glands, peripheral and central nervous system and basal surfaces of gut epithelia. Sdc and robo are coexpressed in domains adjacent to slit; in tracheal pits and midline glia cells.
messages: Membrane

7227:Dmel CG8843
gene id: 7227:Dmel_CG8843
uniprot id: Q9VQQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.

7227:Dmel CG13848
gene id: 7227:Dmel_CG13848
uniprot id: Q9VD09
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Detected from the third larval instar onwards, with maximal expression levels in adult flies.
messages: Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis.
messages: Strongly expressed in retina, where it may localize to pigment cells. Also detected in lamina, medulla, and optic lobes.
messages: Visual response is impaired, characterized by abnormal electroretinogram (ERG) recordings which show loss of the prolonged depolarization afterpotential which normally occurs in response to blue light. Expression levels of the opsins Rh1 and Rh4 are severely decreased.

7227:Dmel CG18810
gene id: 7227:Dmel_CG18810
uniprot id: Q9I7L7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG7739
gene id: 7227:Dmel_CG7739
uniprot id: Q9VUQ7
names: Similarity
messages: Belongs to the TIP family.

7227:Dmel CG10688
gene id: 7227:Dmel_CG10688
uniprot id: Q9VTZ6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (PubMed:26940433). Required for maintaining N-linked glycoprotein glycosylation at the neuromuscular junction (NMJ) synaptomatrix, and thus acts in multiple pathways that prevent NMJ structural overgrowth, restrict synaptic bouton differentiation, and limit NMJ neurotransmission strength, in order to maintain viability, coordinate movement, and in adults ensure correct wing positioning (PubMed:26940433). Acts in the NMJ trans-synaptic Wg pathway via glycosylation of synaptic Mmp2 which enables dlp/wg signaling during development (PubMed:26940433).
messages: RNAi-mediated whole-body knockdown is lethal at larval stage with severe developmental delays (PubMed:26940433). RNAi-mediated whole-body knockdown or combined neural and muscle knockdown, reduces N-linked protein glycosylation at the neuromuscular junction (NMJ) leading to NMJ synaptic overelaboration and decreased amplitude of evoked excitatory junction currents (EJCs) (PubMed:26940433). These structural and functional defects at the NMJ impair coordinated movement needed for viability (PubMed:26940433). Loss of N-linked protein glycosylation at the NMJ, reduces levels of synaptic Mmp2 and thereby the synaptic levels of wg and its coreceptor dlp leading to a down-regulation of the trans-synaptic pathway (PubMed:26940433). RNAi-mediated knockdown either in the neurons or in the muscles, also reduces glycosylation at the NMJ and synaptic overelaboration, however there is no decrease in the amplitude of evoked excitatory junction currents (EJCs) and flies die at the adult stage (PubMed:26940433). Adults display held-out wings and exhibit incoordination which impairs walking or flying (PubMed:26940433). RNAi-mediated knockdown in muscles impairs coordinated movement required for pharate adults to properly eclose, resulting in death (PubMed:26940433).

7227:Dmel CG8151
gene id: 7227:Dmel_CG8151
uniprot id: A0A0B4K726
uniprot id: Q960E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB1 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus

7227:Dmel CG4863
gene id: 7227:Dmel_CG4863
uniprot id: O16797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Cytoplasm
messages: The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

7227:Dmel CG7236
gene id: 7227:Dmel_CG7236
uniprot id: M9MRD8
uniprot id: Q9VMN3
uniprot id: X2J708
uniprot id: X2JD86
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG5192
gene id: 7227:Dmel_CG5192
uniprot id: O01668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells. Rh6 is expressed in a subset of R8 cells, most likely expressed in the subset of R8 cells paired with Rh4-expressing R7 cells (R7y).
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7227:Dmel CG5028
gene id: 7227:Dmel_CG5028
uniprot id: A8JRB8
uniprot id: A8JRC1
uniprot id: Q8MT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Mitochondrion

7227:Dmel CG11783
gene id: 7227:Dmel_CG11783
uniprot id: Q24143
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds selectively to the HSP27 20E response element.
messages: By 20-hydroxyecdysone (20HE) 106 hours after egg laying.
messages: Highest expression in third-instar larvae and prepupae.
messages: Nucleus

7227:Dmel CG6597
gene id: 7227:Dmel_CG6597
uniprot id: M9MRX5
uniprot id: Q9VWB1
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

7227:Dmel CG8625
gene id: 7227:Dmel_CG8625
uniprot id: Q24368
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Component of the NURF complex composed of Caf1-55, E(bx), Nurf-38 and Iswi (PubMed:8521502). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Interacts directly with Chrac-14 and this interaction is further stabilized by associated Chrac-16 (PubMed:10856248).
messages: Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502).
messages: Nucleus
messages: Present throughout embryonic, larval and pupal development and in female adults. Present at low levels in adult males (at protein level).

7227:Dmel CG31414
gene id: 7227:Dmel_CG31414
uniprot id: Q8IMY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

7227:Dmel CG43342
gene id: 7227:Dmel_CG43342
uniprot id: A0A0B4K7B6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG12750
gene id: 7227:Dmel_CG12750
uniprot id: Q9VJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC22 family.
messages: Component of the spliceosome C complex (By similarity). Interacts with eIF4AIII (PubMed:22961380).
messages: Nucleus speckle
messages: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.

7227:Dmel CG4879
gene id: 7227:Dmel_CG4879
uniprot id: Q59E27
uniprot id: Q7YZ98
uniprot id: Q9V433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

7227:Dmel CG14906
gene id: 7227:Dmel_CG14906
uniprot id: Q9VER8
names: Similarity
messages: Belongs to the MT-A70-like family.

7227:Dmel CG3291
gene id: 7227:Dmel_CG3291
uniprot id: E1JJR3
uniprot id: Q9VWI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

7227:Dmel CG13322
gene id: 7227:Dmel_CG13322
uniprot id: Q8T8S1
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

7227:Dmel CG18516
gene id: 7227:Dmel_CG18516
uniprot id: Q9VF50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG18585
gene id: 7227:Dmel_CG18585
uniprot id: Q9VLZ2
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG30149
gene id: 7227:Dmel_CG30149
uniprot id: Q86BY9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which is usually essential for the association with nuclear receptors.
messages: Cytoplasm
messages: Expressed in the brain and salivary glands of early and late second instar larvae. Expressed in nurse cells and oocytes.
messages: Interacts with nuclear receptors EcR, svp (seven up), usp (ultraspiracle), Hr39 and Hr3.
messages: Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation. Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74).
messages: Nucleus

7227:Dmel CG13937
gene id: 7227:Dmel_CG13937
uniprot id: M9PBI7
uniprot id: Q8IRG5
uniprot id: Q9W070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane

7227:Dmel CG5268
gene id: 7227:Dmel_CG5268
uniprot id: A0A0B4LH72
uniprot id: Q9VF08
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TIM16/PAM16 family.
messages: Expressed in distinct cells in the embryonic and larval nervous system.
messages: Highly expressed in early embryos.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, Roe1, TIM44, blp/TIM16 and TIM14. Associates with the TIM23 complex.
messages: Regulates ATP-dependent protein translocation into the mitochondrial matrix (By similarity). Essential for larval development.
messages: The J-like region, although related to the J domain does not have co-chaperone activity.

7227:Dmel CG1139
gene id: 7227:Dmel_CG1139
uniprot id: Q9W056
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter which has pH-dependent electrogenic transport activity for alanine, glycine and proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197).
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane

7227:Dmel CG5886
gene id: 7227:Dmel_CG5886
uniprot id: Q9VBL3
names: Similarity
messages: Belongs to the taxilin family.

7227:Dmel CG2114
gene id: 7227:Dmel_CG2114
uniprot id: M9PBK3
uniprot id: Q9VZW5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A receptor for the FMRFamide peptides (PubMed:12218185, PubMed:12438685). Reacts with high affinity to FMRFamide and intrinsic FMRFamide-related peptides (PubMed:12218185, PubMed:12438685). By stimulating intracellular calcium signaling through the inositol 1,4,5-trisphosphate receptor, Itpr, in dopaminergic neurons, may be involved in the maintenance of neuronal excitability and in the regulation of flight bout duration (PubMed:30110323).
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Deficits in simulated flight behavior with fewer or shorter duration of wing beats in tethered flies (PubMed:30110323). Dopaminergic neuron-specific knockout leads to shorter flight duration (PubMed:30110323). RNAi-mediated knockdown, either in adults or during pupal development, results in similar deficits in simulated flight behavior, whereas knockdown during larval development has no effect on flight behavior in the adult (PubMed:30110323). Pan-neuronal or dopaminergic neuron-specific RNAi-mediated knockdown leads to significantly shorter flight bouts (PubMed:30110323).
messages: Expressed in ovaries, heads and bodies (PubMed:12438685). Expressed in dopaminergic neurons.
messages: Expressed throughout development; strongest in larvae and adults (PubMed:12218185). In larvae, expressed in trachea, brain, gut, fat body and Malpighian tubules (PubMed:30110323).

7227:Dmel CG5121
gene id: 7227:Dmel_CG5121
uniprot id: Q9VBQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 28 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Nucleus

7227:Dmel CG14239
gene id: 7227:Dmel_CG14239
uniprot id: Q9VBF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG44835
gene id: 7227:Dmel_CG44835
uniprot id: Q9W4E2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: All stages of development.
messages: Belongs to the WD repeat neurobeachin family.
messages: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.
messages: Cytoplasm
messages: In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in adults with higher levels in head region. Expressed in larval neurons but not in larval glia.
messages: Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.
messages: Intron retention. In addition to the intron retained at the N-terminus, there are other discrepancies towards the C-terminus.
messages: Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.
messages: Membrane
messages: Mutants are viable and fertile but display a rough eye surface phenotype, impaired short-term memory, aberrant associative odor learning, aberrant neuromuscular junction morphology with increased numbers of synaptic boutons, and defective axonal morphology of the Kenyon cells, the neurons of the mushroom body.
messages: Perikaryon
messages: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

7227:Dmel CG3758
gene id: 7227:Dmel_CG3758
uniprot id: P25932
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the snail C2H2-type zinc-finger protein family.
messages: Expression is complex and dynamic. In early embryogenesis, expression begins on the dorsal side of the embryo. Expressed in a pattern of longitudinal stripes early in germband elongation. Later in embryogenesis, expression is in cells that correspond to the wing, haltere, leg and genital imaginal disks and the abdominal histoblasts. In the embryonic leg disk, expression is restricted to imaginal cells. Also expressed in the central nervous system (CNS), tracheae and head of stage 14 embryos. CNS and tracheal expression decays during later stages, though head expression persists until late in embryogenesis. In third instar larvae, expression is seen in the brain and in regions of many imaginal tissues including the eye-antennal, wing, leg and haltere disks. Expressed in embryonic, larval and adult male germline stem cells and in the somatic cells of the embryonic gonads.
messages: Nucleus
messages: Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ cells. Acts with other members of the snail protein family to control embryonic central nervous system development.

7227:Dmel CG5408
gene id: 7227:Dmel_CG5408
uniprot id: Q9V3Z1
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'tribbles' is named after fictional small round organisms from the Star Trek universe that proliferate uncontrollably.
messages: Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program (PubMed:10850493, PubMed:10850494, PubMed:10837248, PubMed:15581871). Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis and thus mediate cell proliferation (PubMed:10850493, PubMed:10850494, PubMed:10837248, PubMed:15581871, PubMed:23290551, PubMed:29025897). During gastrulation, negatively regulates stg to delay mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place (PubMed:10837248, PubMed:10850493, PubMed:10850494). Delaying stg-dependent mitosis during bristle development and in migrating germline pole cells also arrests their cell divisions, whereas in cystocytes it promotes their cell divisions (PubMed:10837248, PubMed:10850493, PubMed:15581871). Involved in the regulation of the mid-blastula transition; promotes the destruction of twe resulting in the cell cycle arrest in G2 of cycle 14 which delays mitosis and thus reduces cell proliferation allowing cell fate specification and morphogenesis to take place (PubMed:23290551). In germline cells, blocks border cell migration during oogenesis by binding to slbo/C/EBP and promoting its ubiquitination and degradation by the proteasome (PubMed:23305818, PubMed:10949024, PubMed:29025897). May function in a negative feed…
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
messages: Cytoplasm
messages: Expressed throughout the brain with highest levels of expression detected in the cell body rind and lower levels of expression detected in the neurophil (at protein level).
messages: Interacts with slbo (PubMed:10949024). Interacts with Akt1 (PubMed:29025897, PubMed:25329475).
messages: Low viability with only 14% of mutants survive to adulthood (PubMed:10850493). The egg chambers of surviving females often have only eight germline cysts half of which have an oocyte and the other half do not (PubMed:10850493). Early stage 9 to stage 10 embryos, display increased levels of slbo (PubMed:10949024). RNAi-mediated knockdown in embryos produces premature mitosis in part or all of the ventral region, resulting in many mutants displaying defects in gastrulation including partial invagination of the mesoderm (PubMed:10837248). RNAi-mediated knockdown results in an increase in phosphorylated Akt1 but has no effect on total Akt1 levels (PubMed:25329475, PubMed:29025897). RNAi-mediated knockdown in the fat body increases lipid accumulation, larval weight, fat body cell size and the size of fat body nuclei (PubMed:25329475). The increase in larval weight results in delayed pupariation (PubMed:25329475). Flies also display an increase in triglyceride levels which is consistent with the increase in the number and size of lipid bodies (PubMed:25329475). RNAi-mediated knockdown in the fat body does not result in a significant change in triglyceride levels but flies display an increase in glycogen levels and an increase in lipid droplet size (PubMed:29025897). No effect on glucose or trehalose levels in the hemolymph (PubMed:25329475, PubMed:29025897). RNAi-mediated knockdown in late stage border cells, partially reduced border cell migration (PubMed:23305818).
messages: Nucleus
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: Zygotic expression first occurs in the prospective embryonic mesoderm, and later in the ectoderm as well (PubMed:10837248). Expression decreases over embryogenesis (PubMed:10837248). High levels of expression in embryos at the beginning of cycle 14 (PubMed:10850494). During cellularization, expression declines but persists throughout gastrulation and until late embryogenesis (PubMed:10850494). In stage 5 embryos, ubiquitously expressed with increased expression in the ventral region (PubMed:10850493). During gastrulation, highest levels of expression are in the ventral cells (PubMed:10850494).
messages: cell cortex

7227:Dmel CG5363
gene id: 7227:Dmel_CG5363
uniprot id: C0MJ66
uniprot id: P23572
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Expressed both maternally and zygotically (PubMed:2120044, PubMed:8405984). High levels of expression when mitosis is elevated; highest levels of expression are in early embryos with levels decreasing during embryogenesis and remaining low throughout most of larval development, and expression levels are also increased in unfertilized eggs and adult females (PubMed:2120044).
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Component of the Frs-CycA-Cdk1 complex composed of Cdk1, CycA and Z600 (PubMed:17431409).
messages: Nucleus
messages: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.
messages: Plays a key role in the control of the eukaryotic cell cycle (PubMed:2120044, PubMed:15581871). It is required in higher cells for entry into S-phase and mitosis (PubMed:2120044, PubMed:15581871, PubMed:29746464). In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition (PubMed:29746464). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:2120044).

7227:Dmel CG10670
gene id: 7227:Dmel_CG10670
uniprot id: Q9VRJ0
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3' to 5' exonuclease activity reported in PubMed:15576351 is probably artifactual, due to the presence of other nucleases in the preparation.
messages: Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates.
messages: Nucleus
messages: Present in stage 1-4 embryos (at protein level).

7227:Dmel CG18643
gene id: 7227:Dmel_CG18643
uniprot id: A0A0B4LH54
uniprot id: Q9VGP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged endogenous and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (PubMed:28362257). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity).
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

7227:Dmel CG3271
gene id: 7227:Dmel_CG3271
uniprot id: Q7K0P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.

7227:Dmel CG7304
gene id: 7227:Dmel_CG7304
uniprot id: Q8IA44
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to polypeptide N-acetylgalactosaminyltransferase proteins, it lacks the conserved His at position 211 which is part of the Asp-Xaa-His motif which binds the cofactor Mn(2+). This suggests that it may have lost its activity.
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Probable inactive glycosyltransferase.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG7179
gene id: 7227:Dmel_CG7179
uniprot id: Q9VLX5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG17556
gene id: 7227:Dmel_CG17556
uniprot id: Q9VEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

7227:Dmel CG30499
gene id: 7227:Dmel_CG30499
uniprot id: Q95RV5
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

7227:Dmel CG4666
gene id: 7227:Dmel_CG4666
uniprot id: Q9W440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THEM6 family.
messages: Secreted

7227:Dmel CG8719
gene id: 7227:Dmel_CG8719
uniprot id: P40808
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.
messages: Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

7227:Dmel CG9252
gene id: 7227:Dmel_CG9252
uniprot id: Q9VIF5
names: Function
names: Subcellular Location Annotation
messages: Developmental protein involved in oogenesis (PubMed:16616913). Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females (PubMed:16616913). Also required for dorso-ventral and antero-posterior patterning of oocyte and eggshell (PubMed:16616913). May be involved in microtubule function during oogenesis (PubMed:16616913). Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004). Component of the RDC complex (rhi, del and cuff) which binds to repressive H3K9me3 marks in the piRNA clusters (PubMed:28847004). RDC promotes the bidirectional transcription of piRNA clusters at these sites by interacting with Moonshiner which forms a complex with the transcription initiation factors TfIIA-S and Trf2 (PubMed:28847004). This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004).
messages: Nucleus
messages: centrosome

7227:Dmel CG33873
gene id: 7227:Dmel_CG33873
uniprot id: A0A0B4KFZ9
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG2746
gene id: 7227:Dmel_CG2746
uniprot id: P36241
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

7227:Dmel CG32333
gene id: 7227:Dmel_CG32333
uniprot id: M9PGQ5
uniprot id: Q9W0I1
names: Similarity
messages: Belongs to the FAM135 family.

7227:Dmel CG8167
gene id: 7227:Dmel_CG8167
uniprot id: E7BBS1
uniprot id: Q9VT51
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Broadly expressed at a low level in the embryonic mesoderm, beginning at stage 12. Expressed at a high level in the embryonic anterior midgut, with expression diminishing at late stage 16. Expressed at a low level in larval imaginal disks. Expressed at a high level in larval salivary glands and in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.
messages: Expressed in the embryo and larva.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Of the insulin-like peptides, Ilp2 is the closest homolog of human insulin.
messages: Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.
messages: Secreted

7227:Dmel CG32513
gene id: 7227:Dmel_CG32513
uniprot id: G7H830
uniprot id: M9PJS1
uniprot id: Q9VRE2
names: Similarity
messages: Belongs to the popeye family.

7227:Dmel CG14299
gene id: 7227:Dmel_CG14299
uniprot id: A0A0B4K6N7
uniprot id: Q9VE34
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPG5 family.
messages: Conditional CG14299 knockdown in fly larval fat bodies causes defects in the late steps of autophagy and a block in digestion of autolysosomes. Conditional down-regulation in adult fly retina reveals an incremental loss of neurons and of retina structure over time.
messages: Involved in autophagy. Plays a role in late steps of autophagy.
messages: Lysosome
messages: perinuclear region

7227:Dmel CG3008
gene id: 7227:Dmel_CG3008
uniprot id: Q9VR42
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

7227:Dmel CG12690
gene id: 7227:Dmel_CG12690
uniprot id: M9PDZ5
uniprot id: Q9W3Q5
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG11089
gene id: 7227:Dmel_CG11089
uniprot id: Q9VC18
names: Similarity
messages: Belongs to the PurH family.

7227:Dmel CG1319
gene id: 7227:Dmel_CG1319
uniprot id: Q8SZA8
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Mitochondrion
messages: RNAi-mediated knockdown results in larval growth defects, strong larval lethality and strong reduction of ecdysteroid peak level required to proceed to pupal stage (PubMed:25628335). RNAi-mediated knockdown in the prothoracic gland results in larval growth defects and lethality at the third larval stage, with a complete lack of pupariation (PubMed:25628335).
messages: Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition.

7227:Dmel CG7483
gene id: 7227:Dmel_CG7483
uniprot id: Q9VHS8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase (PubMed:22961380). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:22961380). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed:14973490).
messages: Belongs to the DEAD box helicase family.
messages: Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis, where it colocalizes with mago.
messages: Nucleus
messages: Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490, PubMed:22961380). Interacts with btz/CASC3 and mago (PubMed:14973490). Interacts with ncm/CWC22 (PubMed:22961380).

7227:Dmel CG9357
gene id: 7227:Dmel_CG9357
uniprot id: Q9W2M7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG5232
gene id: 7227:Dmel_CG5232
uniprot id: Q9VG74
names: Developmental Stage
names: Function
messages: Expressed at all stages of development.
messages: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:11886840, PubMed:21919466). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:11886840). Essential for biosynthesis of sialic acids in neurons of the central nervous system (PubMed:21919466).

7227:Dmel CG8778
gene id: 7227:Dmel_CG8778
uniprot id: A1Z934
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7227:Dmel CG7447
gene id: 7227:Dmel_CG7447
uniprot id: Q95RQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG9930
gene id: 7227:Dmel_CG9930
uniprot id: Q9VFQ3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG15614
gene id: 7227:Dmel_CG15614
uniprot id: A1ZAL6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG17760
gene id: 7227:Dmel_CG17760
uniprot id: Q8MQV5
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7227:Dmel CG31918
gene id: 7227:Dmel_CG31918
uniprot id: Q9VMU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG9081
gene id: 7227:Dmel_CG9081
uniprot id: I1WYI3
uniprot id: Q9VXY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG1453
gene id: 7227:Dmel_CG1453
uniprot id: A4V4A1
uniprot id: Q960Z0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
messages: Expressed in male germline stem cells and spermatogonia (at protein level).
messages: Interacts with Alms1a (via C-terminus).
messages: Marked perturbation of mitotic spindle architecture (PubMed:14681690). RNAi-knockdown in the male germline abolishes the asymmetric enrichment of Alms1a to the mother centrosome (PubMed:32965218).
messages: Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux' (PubMed:14681690, PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188).
messages: centromere
messages: centrosome
messages: spindle pole

7227:Dmel CG10128
gene id: 7227:Dmel_CG10128
uniprot id: P19018
names: Domain
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Isoform Tmaj and isoform Tmin are expressed in males and females. Isoform msTmaj and isoform msTmin are present only in male germ cells.
messages: Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female-specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to the dsxRE. Protein-RNA and protein-protein interactions are involved in tra-2 dependent activation and repression of alternative splicing. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site.
messages: The RS2 (Arg/Ser-rich domain 2) and RNP-CS (ribonucleoprotein consensus sequence) domains are required for both male sterility and female-specific dsx splicing but the RS1 domain is dispensable.

7227:Dmel CG8573
gene id: 7227:Dmel_CG8573
uniprot id: P08970
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190.
messages: Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:7664338, PubMed:11350941, PubMed:11416154, PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
messages: Expressed in all stages of development.
messages: Nucleus

7227:Dmel CG6574
gene id: 7227:Dmel_CG6574
uniprot id: Q9VGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

7227:Dmel CG3633
gene id: 7227:Dmel_CG3633
uniprot id: Q9W253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

7227:Dmel CG7726
gene id: 7227:Dmel_CG7726
uniprot id: A0A0B4LGZ5
uniprot id: P46222
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with Fmr1 to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are RpL5, Rm62, AGO2 and Dcr-1 (PubMed:12368261).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG13732
gene id: 7227:Dmel_CG13732
uniprot id: Q9VVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

7227:Dmel CG13313
gene id: 7227:Dmel_CG13313
uniprot id: Q9VSR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG15274
gene id: 7227:Dmel_CG15274
uniprot id: Q9V3Q9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6189
gene id: 7227:Dmel_CG6189
uniprot id: Q9W5E4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MYBBP1A family.
messages: Cytoplasm
messages: Has a role in rRNA biogenesis, cell proliferation and tissue growth by contributing to the localization of nclb to the nucleolus.
messages: Interacts with nclb.
messages: Nucleus
messages: Reduced rRNA transcription which results in larval reduced growth (PubMed:29065309). RNAi-mediated knockdown in the fat body results in the mislocalization of nclb from the nucleolus to the nucleoplasm (PubMed:29065309).
messages: nucleolus

7227:Dmel CG12141
gene id: 7227:Dmel_CG12141
uniprot id: Q8SXM8
uniprot id: Q9W327
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7227:Dmel CG1103
gene id: 7227:Dmel_CG1103
uniprot id: Q960K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

7227:Dmel CG3612
gene id: 7227:Dmel_CG3612
uniprot id: P35381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
messages: Mitochondrion inner membrane

7227:Dmel CG16758
gene id: 7227:Dmel_CG16758
uniprot id: M9ND26
uniprot id: M9PE19
uniprot id: Q7KV91
uniprot id: Q7KV94
uniprot id: Q7KV95
uniprot id: Q9W004
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

7227:Dmel CG6917
gene id: 7227:Dmel_CG6917
uniprot id: C9QP21
uniprot id: P08171
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Monomer.
messages: Secreted
messages: Specifically expressed in the ejaculatory bulbs of male.
messages: Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.

7227:Dmel CG34161
gene id: 7227:Dmel_CG34161
uniprot id: A1A6Q5
uniprot id: A2VEK7
names: Similarity
messages: Belongs to the acylphosphatase family.

7227:Dmel CG10110
gene id: 7227:Dmel_CG10110
uniprot id: Q9V726
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160.
messages: Nucleus

7227:Dmel CG7923
gene id: 7227:Dmel_CG7923
uniprot id: Q9VTD4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7227:Dmel CG17082
gene id: 7227:Dmel_CG17082
uniprot id: Q8T0G4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for Rho1; functions with the ERM protein Moe to regulate Rho1 and control proliferation in the developing epithelium. Recruited by Moe to the cell cortex where it negatively regulates Rho1 activity. Can also promote cell proliferation independently of its GAP activity, perhaps by acting with Arf51F (Arf6) to positively regulate Rac1.
messages: Interacts with Moe (via FERM domain).
messages: RNAi-mediated knockdown does not affect epithelial integrity or apoptosis.
messages: cell cortex

7227:Dmel CG10214
gene id: 7227:Dmel_CG10214
uniprot id: Q9VCI0
names: Function
names: Similarity
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.

7227:Dmel CG9203
gene id: 7227:Dmel_CG9203
uniprot id: Q9VXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

7227:Dmel CG5093
gene id: 7227:Dmel_CG5093
uniprot id: Q9VST0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG12084
gene id: 7227:Dmel_CG12084
uniprot id: Q9W0E8
names: Function
names: Similarity
messages: Belongs to the zyg-11 family.
messages: Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.

7227:Dmel CG4957
gene id: 7227:Dmel_CG4957
uniprot id: Q9VL11
names: Similarity
messages: Belongs to the TACO1 family.

7227:Dmel CG7390
gene id: 7227:Dmel_CG7390
uniprot id: H8F4T3
uniprot id: Q9VFG5
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.

7227:Dmel CG40351
gene id: 7227:Dmel_CG40351
uniprot id: Q5LJZ2
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.
messages: Chromosome
messages: Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Interacts with ash2 and wds.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus

7227:Dmel CG31286
gene id: 7227:Dmel_CG31286
uniprot id: Q8INR8
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5825
gene id: 7227:Dmel_CG5825
uniprot id: C0HL66
uniprot id: C0HL67
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: High levels of expression in ovaries and relatively weak expression in the testes. Highest levels of expression in embryos.
messages: Low levels of expression in ovaries and moderate levels of expression in the testes. Highest levels of expression in embryos.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression. Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Daxx (via C-terminus) (PubMed:28320872).
messages: This histone is the predominant form in non-dividing cells.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

7227:Dmel CG7729
gene id: 7227:Dmel_CG7729
uniprot id: Q9VVD2
names: Similarity
messages: Belongs to the kindlin family.

7227:Dmel CG17453
gene id: 7227:Dmel_CG17453
uniprot id: C9QPG6
uniprot id: Q9V776
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG31519
gene id: 7227:Dmel_CG31519
uniprot id: P82986
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG15309
gene id: 7227:Dmel_CG15309
uniprot id: K7X7R3
uniprot id: Q9W2X7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the yippee family.
messages: In larvae, predominantly expressed in subsets of neurons, including a subset of sensory neurons comprising the class IV dendritic arborization (da) neurons (nociceptors), class III da neurons and chordotonal neurons (both mechanosensors).
messages: Involved in regulating synaptic transmission in presynaptic neurons (PubMed:32461240). In class IV dendritic arborization neurons (nociceptors), involved in regulating activation of their second-order neurons (SONs) and maintaining synaptic contact between nociceptors and their SONs (PubMed:32461240).
messages: Larvae display reduced nociceptive rolling behavior due to impaired activation of second-order neurons (SONs) in the nociceptive pathway and reduced the synaptic contact between nociceptors and their SONs.

7227:Dmel CG10537
gene id: 7227:Dmel_CG10537
uniprot id: M9PBZ1
uniprot id: M9PEV8
uniprot id: M9PHV2
uniprot id: P25123
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by agonist muscimol (PubMed:8016117, PubMed:12805302, PubMed:8389005, PubMed:24823815). Insensitive to zinc, glycine, glutamate, and baclofen, loreclezole, to antagonist bicuculline, glycine-receptor antagonist strychnine, and nonselective GABA and glycine antagonist RU 5135 (PubMed:8016117, PubMed:8389005, PubMed:8882620, PubMed:12805302). Insensitive to flunitrazepam, pentobarbitone or pregnane steroids such as 5alpha-pregnan-3alpha-ol-20-one (PubMed:8016117, PubMed:8882620, PubMed:12805302). Inhibited by insecticides picrotoxin (PTX), cyclodiene dieldrin, TBPS and lindane (PubMed:8016117, PubMed:8389005, PubMed:7527461). Inhibited by ivermectin, fipronil and pyrafluprole (PubMed:24823815).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
messages: Cell membrane
messages: Expressed in different parts of the brain: the mushroom bodies (alpha, alpha', beta, beta', gamma lobes and peduncles), the neurons projecting to the columnar-type neuron LC9 optic glomerulus, in interneurons connecting the paired olfactory lobes, antennal lobes, PDF-expressing small and large ventral lateral neurons (LNvs) of the circadian clock and lobula columnar neuron 11 (LC11) (at protein level) (PubMed:18093529, PubMed:19038223, PubMed:32339168, PubMed:19230663, PubMed:24068821, PubMed:29174887, PubMed:32075756). Expressed in all major ON pathway medulla neurons (Mi1, Tm3, Mi4, and Mi9) and in OFF pathway neurons (Tm1, Tm2, Tm4, and Tm9) (PubMed:31535971).
messages: Forms oligomers (PubMed:8882620). Interacts with Nlg4; the interaction mediates Rdl clustering (PubMed:24068821). Interacts with Fbxl4; the interaction mediates Rdl degradation (PubMed:29174887).
messages: Gamma-aminobutyric acid (GABA) receptor voltage channel subunit (PubMed:8016117, PubMed:8389005, PubMed:7527461, PubMed:8882620, PubMed:12805302, PubMed:24823815). GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel (PubMed:8389005, PubMed:7527461, PubMed:12805302). Together with glutamate receptor GluClalpha, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons (PubMed:31535971, PubMed:32075756). Plays a role in promoting sleep and sleep latency by regulating the activity of peptidergic PDF neurons (PubMed:18223647, PubMed:19038223, PubMed:19230663). In large ventral lateral clock neurons, clustering is mediated by Nlg4 and protein levels undergo daily degradation in response to the circadian clock (PubMed:24068821, PubMed:29174887). In neurons in the mushroom bodies, has a role in odor memory acquisition where it inhibits appetitive and aversive olfactory learning, probably upstream of adenylyl cyclase rut and GTPase activating protein Nf1 (PubMed:18093529, PubMed:19193904). In male-specific GABAergic neurons, plays a role in inhibiting male aggressive behavior during courtship (PubMed:24241395).
messages: Gamma-aminobutyric acid (GABA) receptor voltage channel subunit.
messages: In large ventral lateral neurons (lLNvs), undergoes daily rhythmic degradation which is inversely correlated with the activity of lLNvs, which is involved in the circadian clock (PubMed:29174887). Degradation levels are increased in the early hours of the morning and mediated by the E3 ubiquitin ligase Fbxl4 (PubMed:29174887).
messages: In lobula columnar neurons 11 (LC11) results in a reduction of visual responses to the motion of small objects (PubMed:32075756). RNAi-mediated knockdown in neurons leads to dis-inhibition of male aggressive behavior (PubMed:24241395). RNAi-mediated knockdown in neurons in the alpha/beta mushroom bodies enhances learning (PubMed:18093529). RNAi-mediated knockdown in mushroom bodies enhances appetitive olfactory learning (PubMed:19193904). RNAi-mediated knockdown in PDF-expressing neurons results in decreased sleep but does not alter waking activity, circadian period, or rhythmicity under dark-dark conditions (PubMed:19230663). Simultaneous knockout of adenylate cyclase rut does not enhance the phenotype (PubMed:19193904). Simultaneous knockout of E3 ligase Fbxl4 results in significantly increased duration of daytime sleep and nighttime sleep as well as shortened sleep onset latency (PubMed:29174887).
messages: Inhibited by insecticides picrotoxin (PTX).
messages: Membrane
messages: Partially edited.
messages: Postsynaptic cell membrane
messages: Resistance is thought to be due to insensitivity of the cyclodiene/picrotoxinin binding site on the GABA(A) receptor-chloride ionophore complex.
messages: axon
messages: dendrite

7227:Dmel CG9473
gene id: 7227:Dmel_CG9473
uniprot id: E1JIH5
uniprot id: Q8MSX2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
messages: Component of the Mediator complex, which includes at least MED4, MED6, MED14, MED17, MED18, MED20, MED21, MED23, MED24, MED27, MED30 and MED31.
messages: Component of the Mediator complex.
messages: Maternally encoded. Expression decreases during larval stages then rises during mid-pupal metamorphosis.
messages: Nucleus

7227:Dmel CG9501
gene id: 7227:Dmel_CG9501
uniprot id: Q9VME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG1938
gene id: 7227:Dmel_CG1938
uniprot id: Q8IR93
uniprot id: Q9VZ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

7227:Dmel CG18371
gene id: 7227:Dmel_CG18371
uniprot id: Q4V6I0
names: Similarity
messages: Belongs to the acylphosphatase family.

7227:Dmel CG18426
gene id: 7227:Dmel_CG18426
uniprot id: Q9W1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

7227:Dmel CG6392
gene id: 7227:Dmel_CG6392
uniprot id: M9PCX3
uniprot id: M9PD87
uniprot id: M9PFL9
uniprot id: Q9VKI0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG6744
gene id: 7227:Dmel_CG6744
uniprot id: Q9VGN7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exoribonuclease required for mitochondrial metabolism.
messages: Belongs to the EXD2 family.
messages: Developmental delays and premature female germline stem cell attrition, reduced fecundity, associated with a dramatic extension of lifespan that is reversed with an antioxidant diet.
messages: Divalent metal cations; Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Mitochondrion membrane

7227:Dmel CG8680
gene id: 7227:Dmel_CG8680
uniprot id: Q9VMU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

7227:Dmel CG11001
gene id: 7227:Dmel_CG11001
uniprot id: P48375
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands.

7227:Dmel CG15925
gene id: 7227:Dmel_CG15925
uniprot id: A1ZAG4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Endoplasmic reticulum membrane
messages: Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. Required for amino acid starvation-induced mono-ADP-ribosylation and subsequent formation of Sec bodies - which are stress assemblies that promote cell survival by preserving components of the ER exit sites (ERES) during amino-acid starvation. Catalyzes the mono-ADP-ribosylation of Sec16 which is essential for Sec body formation.
messages: The lumenal and transmembrane domains are necessary for mono-ADP-ribosylation and Sec body formation.

7227:Dmel CG2111
gene id: 7227:Dmel_CG2111
uniprot id: Q9W2S7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG9213
gene id: 7227:Dmel_CG9213
uniprot id: Q9VXT5
uniprot id: X2JKF2
names: Similarity
messages: Belongs to the CWF19 family.

7227:Dmel CG4532
gene id: 7227:Dmel_CG4532
uniprot id: A8JV09
uniprot id: D6W4T8
uniprot id: Q9W3W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

7227:Dmel CG6687
gene id: 7227:Dmel_CG6687
uniprot id: Q9VFC1
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG12919
gene id: 7227:Dmel_CG12919
uniprot id: Q8MUJ1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tumor necrosis factor family.
messages: By gamma-radiation (PubMed:12894227). By bacterial infection (PubMed:20505310).
messages: Cell membrane
messages: Cytokine which acts as a ligand for wgn (PubMed:12894227). Also acts as a ligand for grnd (PubMed:25874673). Induces apoptosis by triggering JNK signaling (PubMed:12176339, PubMed:12065414, PubMed:12894227). Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells (PubMed:24066226). Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid (PubMed:25754009). Involved in the innate immune response to extracellular pathogens (PubMed:17381241). Plays a role in the melanization immune response through its involvement in the rupture of crystal cells and subsequent release of prophenoloxidase (PubMed:17356067). Following UV-induced epidermal damage, released from apoptotic epidermal cells, binds to the wgn receptor on nociceptive sensory neurons and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious (PubMed:19375319). Involved in glial cell division induced by neuronal programmed cell death and injury (PubMed:19019992). Has tumor suppressor activity and eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity (PubMed:19289090).
messages: During embryogenesis, highly expressed in glial cells and neurons (at protein level) (PubMed:25754009). Highly localized to the dorsal surface of pregastrulating embryos (PubMed:12894227). During gastrulation, expression occurs in the epidermal layer of the embryo and is most prominent at the surface of dorsal folds that will later form the amnioserosa (PubMed:12894227). At germ band extended stages, prominent in the neurogenic region adjacent to the mesodermal segments of the embryo (PubMed:12894227). In later-staged embryos at stages 15/16, detected in subsets of cells within the condensing nerve cord (PubMed:12894227). After embryonic stage 10, predominantly detected in the nervous system (PubMed:12065414). In the third instar larva, strongly expressed in the brain hemispheres and at the morphogenetic furrow in the eye disk (PubMed:12065414). Also expressed at significant levels in many cells posterior to the furrow and in the proliferating cells at the furrow (PubMed:12065414). In the adult, expressed in the fat body (PubMed:20505310).
messages: Isoform 1 and isoform 2 are expressed throughout development and in the adult. Isoform 1 predominates at each stage by about 5 to 10-fold.
messages: N-glycosylated.
messages: Reduced resistance to extracellular pathogens (PubMed:17381241). Complete absence of thermal allodynia in mutant larvae exposed to UV radiation (PubMed:19375319). RNAi-mediated knockdown in the adult fat body results in increased survival following S.typhimurium infection, increased levels of diptericin and reduced feeding rate (PubMed:20505310).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

7227:Dmel CG3476
gene id: 7227:Dmel_CG3476
uniprot id: C0MKK1
uniprot id: Q9VM51
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis.
messages: Membrane
messages: Mitochondrion membrane
messages: RNAi-mediated knockdown results in accumulation of magnesium ions in mitochondria, and reduced lifespan. A magnesium-deficient diet rescues the reduced lifespan phenotype.

7227:Dmel CG32257
gene id: 7227:Dmel_CG32257
uniprot id: P83294
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.

7227:Dmel CG14982
gene id: 7227:Dmel_CG14982
uniprot id: Q9VZK7
names: Similarity
messages: Belongs to the FAM110 family.

7227:Dmel CG6944
gene id: 7227:Dmel_CG6944
uniprot id: P08928
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Constitutively expressed in all developmental stages, especially during the first 6-9 hours.
messages: Constitutively expressed in all tissues (at protein level) (PubMed:7593280). Expressed in spermatocytes (at protein level) (PubMed:27402967).
messages: Cytoplasm
messages: Interacts directly with LBR (PubMed:15054108). Interacts with MAN1 (PubMed:16439308). Interacts with Ote (PubMed:9632815, PubMed:22751930).
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:3126192, PubMed:15035436). May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308). In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967). Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811). In addition, is required for nuclear envelope localization of klar (PubMed:14617811).
messages: Nucleus
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus lamina
messages: RNAi-mediated knockdown in spermatocytes results in spindle envelope disintegration, failure to form contractile rings and central spindle microtubules during meiosis I resulting in abnormal cytokinesis and multinuclear cell formation.
messages: Three forms of lamin have been identified in D.melanogaster, lamin Dm0 is rapidly processed to lamin Dm1 in the cytoplasm, Dm1 is then assembled in the nuclear envelope and is then phosphorylated, forming lamin Dm2.
messages: spindle pole

7227:Dmel CG10385
gene id: 7227:Dmel_CG10385
uniprot id: P50535
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the msl-1 family.
messages: Chromosome
messages: Component of the male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3 (PubMed:16543150). Interacts with tamo via the nuclear localization signal (PubMed:12653959).
messages: Nucleus
messages: The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B.

7227:Dmel CG8276
gene id: 7227:Dmel_CG8276
uniprot id: E2QC61
uniprot id: Q7K480
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily.
messages: Detectable in early embryos. Present coincident with bicoid/bcd expression, with peak levels detected in 0-2 hours embryos. Expression is lower during cellularization stages (2-4 hours) and drops dramatically during late embryonic development (4-24 hours). Very little, if any expression is detected in unfertilized eggs.
messages: Distributed throughout the early embryo.
messages: Interacts with bicoid/bcd.
messages: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (By similarity). Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex (PubMed:21262214).
messages: Severe defect in oogenesis: females lay eggs, however, up to 50% do not initiate development and many show a dorsalized phenotype. Among the eggs that do initiate development, up to 20% fail to complete embryogenesis and of these, nearly all display severe head defects and die as unhatched larvae or die soon after hatching. Mutants show anterior pattern defects and fail to repress the translation of caudal mRNA and exhibit head involution defects. Mutants also display a severe reduction in the level of 7SK RNA and reduced binding of bicoid/bcd to the caudal 3' UTR.

7227:Dmel CG17594
gene id: 7227:Dmel_CG17594
uniprot id: A8Y525
uniprot id: A8Y527
uniprot id: Q7PL95
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5709
gene id: 7227:Dmel_CG5709
uniprot id: O76924
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Interacts with Ubc10 (PubMed:10880484). Interacts with park (PubMed:29689197). Interacts with ari-1 (PubMed:29689197).
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
messages: Nucleus
messages: Overexpression does not rescue clustering of muscle nuceli in ari-1 mutants.

7227:Dmel CG30011
gene id: 7227:Dmel_CG30011
uniprot id: A1Z851
uniprot id: Q8SY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

7227:Dmel CG7993
gene id: 7227:Dmel_CG7993
uniprot id: Q9VEB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs.
messages: nucleolus

7227:Dmel CG9164
gene id: 7227:Dmel_CG9164
uniprot id: Q9VXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

7227:Dmel CG9907
gene id: 7227:Dmel_CG9907
uniprot id: B7Z0Z2
uniprot id: M9MS61
uniprot id: M9MS65
uniprot id: M9MS66
uniprot id: M9MS69
uniprot id: M9MS71
uniprot id: M9MS73
uniprot id: M9MS75
uniprot id: M9MS78
uniprot id: M9MS79
uniprot id: M9MS83
uniprot id: M9MS84
uniprot id: M9MS87
uniprot id: M9MS88
uniprot id: M9MS91
uniprot id: M9MS92
uniprot id: M9MS95
uniprot id: M9MS96
uniprot id: M9MSA0
uniprot id: M9MSA3
uniprot id: M9MSB4
uniprot id: M9MSB8
uniprot id: M9MSC3
uniprot id: M9MSC7
uniprot id: M9MSD2
uniprot id: M9MSD5
uniprot id: M9MSD6
uniprot id: M9MSD7
uniprot id: M9MSD8
uniprot id: M9MSE0
uniprot id: M9MSE1
uniprot id: M9MSE2
uniprot id: M9MSE4
uniprot id: M9MSE6
uniprot id: M9MSE7
uniprot id: M9MSE9
uniprot id: M9MSF1
uniprot id: M9MSF2
uniprot id: M9MSP1
uniprot id: M9MSP2
uniprot id: M9MSP3
uniprot id: M9MSP4
uniprot id: M9MSP5
uniprot id: M9MSP6
uniprot id: M9MSP7
uniprot id: M9MSP9
uniprot id: M9MSQ0
uniprot id: M9PJP5
uniprot id: P35500
uniprot id: X2JFE8
uniprot id: X2JKQ0
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
messages: Cell membrane
messages: Isoform exonb and isoform D are seen in embryos and adults. Isoform A, isoform F24 and isoform F30 are predominant in embryos and isoform C and isoform E predominant in adults.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: Partially edited. Further sites are edited by Adar. Positions 1455 and 1587 show minimal editing from embryos through to third larval instar, then a 40-fold increase at pupation. Position 471 has slightly higher levels during early development with only a four-fold increase at pupation.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

7227:Dmel CG5715
gene id: 7227:Dmel_CG5715
uniprot id: Q9VC98
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG10120
gene id: 7227:Dmel_CG10120
uniprot id: Q2QBM1
uniprot id: Q9VG31
uniprot id: Q9VG32
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

7227:Dmel CG7277
gene id: 7227:Dmel_CG7277
uniprot id: Q9VMQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

7227:Dmel CG2928
gene id: 7227:Dmel_CG2928
uniprot id: Q94913
names: Developmental Stage
names: Function
names: Sequence Caution
names: Tissue Specificity
messages: Expressed in 24 hours embryo.
messages: Expressed in head, but not in the body. Expression levels oscillate with the circadian rhythm.
messages: Intron retention.
messages: Involved in the generation of biological rhythms (Potential). In the head, oscillates in abundance with a daily peak during early night, even under constant darkness. Oscillation is dependent on period (per) function.

7227:Dmel CG5000
gene id: 7227:Dmel_CG5000
uniprot id: A0A0B4K664
uniprot id: A0A0B4K700
uniprot id: E1JIM4
uniprot id: Q9VEZ3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOG/XMAP215 family.
messages: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization. Seems to be involved in elongation of kinetochore-derived microtubule fibers.
messages: Expressed in embryos (at protein level).
messages: Interacts with tacc, dgt6 (PubMed:11433295, PubMed:19836241). Interacts with mv (PubMed:33725482).
messages: The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice. TOG 1-2 show strong and TOG 3-4 weak tubulin binding; TOG 1-5 are required for full ability to promote MT polymerization.
messages: centrosome
messages: spindle

7227:Dmel CG6092
gene id: 7227:Dmel_CG6092
uniprot id: Q9VBI2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Nucleus

7227:Dmel CG12311
gene id: 7227:Dmel_CG12311
uniprot id: M9PG53
uniprot id: Q9W5D4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At the cellular blastoderm stage, expression accumulates in the ventrally located mesoderm primordium. At germ band extension, mesoderm expression is seen as stripes of strong expression. A very strong signal is also detected in the invaginating gut. As the germ band retracts, mesodermal expression decays and becomes restricted to somatic muscle precursors.
messages: Belongs to the glycosyltransferase 39 family.
messages: Death during development, the few adult escapers exhibit clockwise rotation of the abdomen.
messages: Endoplasmic reticulum membrane
messages: Expressed throughout development; expression peaks at embryonic stages 8-16.
messages: Interacts with Rt/POMT1.
messages: Membrane
messages: Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

7227:Dmel CG9024
gene id: 7227:Dmel_CG9024
uniprot id: P10334
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Main cells and secondary cells of the accessory glands of 1 day old virgin males (at protein level) (PubMed:2257979). In 5 day old virgin males, only detected in the secondary cells (at protein level) (PubMed:2257979). Reappears in the main cells after mating (at protein level) (PubMed:2257979). First detected in adult males 3-4 hr after eclosion, levels increase reaching a peak at day 3-5 which is maintained until at least day 10 of adulthood (at protein level) (PubMed:2257979). In unmated male adults, levels are maintained for the first 6 days of adulthood and then gradually decrease for at least the next 8 days (PubMed:2257979). No expression in females (PubMed:3142802).
messages: This protein is transferred from male to female during mating and may affect egglaying and behavior after mating.
messages: Up-regulated in response to mating.
messages: extracellular space

7227:Dmel CG17119
gene id: 7227:Dmel_CG17119
uniprot id: Q7YZ90
uniprot id: Q9VCR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes.
messages: Lysosome membrane
messages: Membrane

7227:Dmel CG17819
gene id: 7227:Dmel_CG17819
uniprot id: Q9VD65
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7227:Dmel CG11778
gene id: 7227:Dmel_CG11778
uniprot id: A1Z7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

7227:Dmel CG8403
gene id: 7227:Dmel_CG8403
uniprot id: A1ZA87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7113
gene id: 7227:Dmel_CG7113
uniprot id: O18404
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By 20-hydroxyecdysone.
messages: Embryonic and pupal lethal. Male mutants show small testes and degenerating spermatocytes with a large accumulation of small fat-containing vesicles in the cytoplasm and almost no mitochondria. Null mutant photoreceptors fail to differentiate normally, are unable to form proper rhabdomeres and present smaller mitochondria with fewer, but swollen crestae, than wild-type cells.
messages: Expressed throughout embryonic development. In adults, expression is higher in females than in males.
messages: Found in many tissues including CNS, imaginal disks and salivary glands. Highest expression in both embryonic gonadal primordia and mature ovaries and testes.
messages: Mitochondrion
messages: Multimer.
messages: Versatile enzyme presenting two types of activity; L-3-hydroxyacyl-CoA dehydrogenase ((3S)-3-hydroxyacyl-CoA dehydrogenase) activity and hydroxysteroid dehydrogenase (HSD) activity with a wide substrate spectrum. As a (3S)-3-hydroxyacyl-CoA dehydrogenase, it functions in the third step of the fatty acid beta-oxidation pathway, a major metabolic process in which fatty acids are oxidized to provide a significant source of energy, while also generating acyl-CoA metabolites used by many metabolic routes (PubMed:12917011) (Probable). As a HSD, it functions in the degradation pathways of glucocorticoids and sex steroids and epimerization of bile acids; catalyzes the beta-oxidation at position 17 of androgens and estrogens, has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone, and carries out oxidative conversions of 7-beta-hydroxylated bile acids like ursodeoxycholate or isoursodeoxycholate (also known as 3-beta,7-beta-dihydroxy-5-beta-cholan-24-oate or 7-beta-hydroxyisolithocholate, respectively). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). Required for cell survival during embryonic development. May play a role in germline formation (PubMed:9585418, PubMed:12917011).

7227:Dmel CG11143
gene id: 7227:Dmel_CG11143
uniprot id: O97477
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the myo-inositol 1-phosphate synthase family.
messages: Cytoplasm
messages: Higher expression in adult heads than bodies.
messages: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:11121586). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).

7227:Dmel CG11582
gene id: 7227:Dmel_CG11582
uniprot id: Q9VZE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

7227:Dmel CG6287
gene id: 7227:Dmel_CG6287
uniprot id: Q9VKI8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7227:Dmel CG5055
gene id: 7227:Dmel_CG5055
uniprot id: Q0KHR3
uniprot id: Q9VX75
uniprot id: X2JCB3
uniprot id: X2JFU8
names: Similarity
messages: Belongs to the PAR3 family.

7227:Dmel CG3530
gene id: 7227:Dmel_CG3530
uniprot id: Q7KK51
uniprot id: Q8MLR7
uniprot id: Q9W1Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

7227:Dmel CG6679
gene id: 7227:Dmel_CG6679
uniprot id: Q9VCS8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG45090
gene id: 7227:Dmel_CG45090
uniprot id: C0HJH4
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with SERCA.
messages: Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction.
messages: Sarcoplasmic reticulum membrane
messages: SclA and SclB double mutants show arrhythmic cardiac contractions and correspondingly, cardiac cells show irregular action potentials (APs), involving double and occasionally failed APs. Calcium transients in these mutants show higher amplitudes and steeper decay than those in wild type flies.
messages: Strongly expressed in embryonic and larval somatic muscles and postembryonic heart.
messages: T-tubule
messages: This protein is produced by a bicistronic gene which also produces the SclB protein from a non-overlapping reading frame.

7227:Dmel CG7494
gene id: 7227:Dmel_CG7494
uniprot id: Q9VHT5
names: Subcellular Location Annotation
messages: Mitochondrion

7227:Dmel CG9362
gene id: 7227:Dmel_CG9362
uniprot id: Q9VHD3
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily. Zeta family.
messages: Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).
messages: Cytoplasm
messages: Expressed during embryogenesis.
messages: Glutathione is required for the MAAI activity.

7227:Dmel CG6750
gene id: 7227:Dmel_CG6750
uniprot id: Q9VKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane

7227:Dmel CG4974
gene id: 7227:Dmel_CG4974
uniprot id: Q24114
uniprot id: Q53XG2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate (PubMed:8582281, PubMed:35609633). Required for cell division patterning during postembryonic development of the nervous system (PubMed:8582281). Plays a role in dpp/BMP signaling possibly by stabilizing dpp and thereby creating a morphological gradient during wing development (PubMed:35609633). Might have a role in testis development (PubMed:35609633).
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: Expressed ubiquitously with elevated signal at the anterior-posterior (A/P) and dorsoventral (D/V) compartment boundaries and in peripheral wing disk cells (at protein level).
messages: Interacts with nord; the interaction promotes dally degradation.

7227:Dmel CG33344
gene id: 7227:Dmel_CG33344
uniprot id: H5V8A1
uniprot id: Q868T3
names: Caution
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Binds to the cardioactive peptide (CCAP), which is a neuropeptide.
messages: Cell membrane
messages: Expressed in all stages, with abundance in embryo and only very weakly in larvae.
messages: In adults, expressed abundantly in the head and very weakly in the body.
messages: Intron retention.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG2720
gene id: 7227:Dmel_CG2720
uniprot id: Q9VPN5
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG32579
gene id: 7227:Dmel_CG32579
uniprot id: M9PHA4
uniprot id: M9PHV9
uniprot id: Q8IR18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG31663
gene id: 7227:Dmel_CG31663
uniprot id: M9NCQ1
uniprot id: Q9VQ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7227:Dmel CG8443
gene id: 7227:Dmel_CG8443
uniprot id: A0A0B4KEX0
uniprot id: A1ZAB5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Causes mitochondria to cluster within cells.
messages: Cytoplasm
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

7227:Dmel CG8084
gene id: 7227:Dmel_CG8084
uniprot id: Q26307
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Negatively regulates proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
messages: Secreted
messages: Synthesized in some glial cells and secreted.

7227:Dmel CG4607
gene id: 7227:Dmel_CG4607
uniprot id: Q9W3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG4501
gene id: 7227:Dmel_CG4501
uniprot id: Q9V3S9
names: Disruption Phenotype
names: Function
names: Similarity
messages: Adult neurodegeneration, with marked dilation of photoreceptor axons (PubMed:10373116, PubMed:26893370, PubMed:29739804). Results in degeneration of lamina and retina, defects in the fenestrated basement membrane and ommatidial disarray (PubMed:26893370, PubMed:29739804). The phenotype is exacerbated in constant light conditions and improves in total darkness (PubMed:29739804). Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs) (PubMed:10373116, PubMed:29739804). Feeding the fly mutant with glyceryl trioleate oil or medium-chain fatty acids, blocks the accumulation of excess VLCFAs as well as development of the pathology (PubMed:10373116, PubMed:29739804). Results in altered neuronal function, including altered sleep rebound following sleep deprivation (PubMed:25409104). Simultaneous knockout of hll results in enhanced retinal degeneration and altered fatty acids metabolism (PubMed:26893370).
messages: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
messages: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10373116, PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104).

7227:Dmel CG4335
gene id: 7227:Dmel_CG4335
uniprot id: Q9VDM7
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

7227:Dmel CG11427
gene id: 7227:Dmel_CG11427
uniprot id: Q9W4K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

7227:Dmel CG3582
gene id: 7227:Dmel_CG3582
uniprot id: Q94535
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with a 65 kDa protein.
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
messages: Nucleus

7227:Dmel CG12227
gene id: 7227:Dmel_CG12227
uniprot id: Q9W1Q0
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG11900
gene id: 7227:Dmel_CG11900
uniprot id: Q9VAM9
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the MESH1 family.
messages: Induces retarded body growth and impaired starvation resistance. Mutants have highly down-regulated DNA and protein synthesis-related genes and up-regulated stress-responsible genes.
messages: ppGpp hydrolyzing enzyme involved in starvation response.

7227:Dmel CG6839
gene id: 7227:Dmel_CG6839
uniprot id: Q9VVU9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7227:Dmel CG3093
gene id: 7227:Dmel_CG3093
uniprot id: Q24314
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS18 family.
messages: Component of the class C core vacuole/endosome tethering (CORVET) complex composed of at least dor/Vps18, Vps16A, Vps8 and car/Vps33A; unlike in other species, Vps11 is not part of the Drosophila complex (PubMed:27253064). Interacts with car (PubMed:10549280). Interacts with ema (PubMed:20194640).
messages: Early endosome
messages: Expressed both maternally and zygotically in all stages of development (PubMed:9065698). Highest expression is in third larval instar (PubMed:9065698, PubMed:10549280). Expressed in the larval Garland nephrocytes and in the adult (at protein level) (PubMed:10549280, PubMed:27253064).
messages: Flies display impaired deposition of pigment granules (PubMed:9065698, PubMed:10549280). Member of the 'granule group' of eye color genes as mutants affect deposition in pigment granules of two types of pigments, the ommochromes and drosopterins (PubMed:9065698, PubMed:10549280). RNAi-mediated knockdown results in late endosome fragmentation and mislocalization of Vps8 (PubMed:27253064).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex (PubMed:9065698, PubMed:10549280, PubMed:27253064, PubMed:25422373). In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route (PubMed:25422373). Required for the biogenesis of eye pigment granules (PubMed:10549280). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599).

7227:Dmel CG42352
gene id: 7227:Dmel_CG42352
uniprot id: Q9V9N1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: In the antenna, detected in sacculus neurons which innervate the first and second chambers (at protein level).
messages: Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the hygrosensory sacculus neurons to changes in relative humidity and is required for dry detection behavior (PubMed:27161501, PubMed:27656904).
messages: Response of sacculus neurons to changes in humidity is abolished and consequently larvae fail to move towards their preferred humidity.

7227:Dmel CG32505
gene id: 7227:Dmel_CG32505
uniprot id: O76932
uniprot id: X2JG90
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Protein phosphatase that regulates many processes such as microtubule organization at centrosomes. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase-induced cell death (in vitro).
messages: Reversibly methyl esterified on Leu-307 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits (By similarity). Probably part of a PP4 PPP4C-PPP4R2-PPP4R3 complex containing Pp4-19C, PPP4R2r and flfl.
messages: centrosome

7227:Dmel CG43370
gene id: 7227:Dmel_CG43370
uniprot id: A1ZAV1
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the antennae of chordotonal neurons and male germ cells (at protein level).
messages: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).
messages: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
messages: centriole
messages: cilium basal body

7227:Dmel CG6117
gene id: 7227:Dmel_CG6117
uniprot id: P16912
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Does not have an essential role in development.
messages: Expressed in embryonic mesoderm, and the optic lamina, wing disk and leg disks of third instar larvae. More abundant in adult head than adult body.
messages: Expressed throughout development.

7227:Dmel CG18803
gene id: 7227:Dmel_CG18803
uniprot id: B7Z090
uniprot id: M9PFS2
uniprot id: M9PG70
uniprot id: O02194
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Cleaved. The cleavage, which probably takes place between the 6th and the 7th transmembrane regions, may be required for activation of the gamma-secretase activity.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically throughout development.
messages: Golgi apparatus membrane
messages: Homodimer (By similarity). Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2. Interacts with Mettl2. Isoform 2 shows a better interaction with Mettl2 than isoform 1.
messages: Homodimer.
messages: Maternally expressed in nurse and follicle cells. In early embryos, expressed in all or most cells and later increases in CNS and epidermal tissues. In larvae, expression is seen in all imaginal disks, brain and optic lobes. In pupae, expression is seen in eye disk and brain.
messages: Membrane
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

7227:Dmel CG17197
gene id: 7227:Dmel_CG17197
uniprot id: Q9VBM7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG13401
gene id: 7227:Dmel_CG13401
uniprot id: Q9VLL0
names: Function
names: Sequence Caution
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.
messages: Insertion of a few bases causing frameshift at residue 295.

7227:Dmel CG10122
gene id: 7227:Dmel_CG10122
uniprot id: P91875
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
messages: Phosphorylated.
messages: nucleolus

7227:Dmel CG34424
gene id: 7227:Dmel_CG34424
uniprot id: Q8MLS1
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

7227:Dmel CG3434
gene id: 7227:Dmel_CG3434
uniprot id: Q9VSZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

7227:Dmel CG7825
gene id: 7227:Dmel_CG7825
uniprot id: O96532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

7227:Dmel CG13029
gene id: 7227:Dmel_CG13029
uniprot id: Q8IQN9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7227:Dmel CG7672
gene id: 7227:Dmel_CG7672
uniprot id: P13360
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor required for gene expression specific to photoreceptor cells.

7227:Dmel CG6181
gene id: 7227:Dmel_CG6181
uniprot id: Q9VKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat EDC4 family.
messages: Homodimer (Probable). Interacts with Dcp1 and Dcp2 (PubMed:18755833). Interacts with Gyf (PubMed:31114929).
messages: In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets.
messages: P-body

7227:Dmel CG5720
gene id: 7227:Dmel_CG5720
uniprot id: Q9V3H9
names: Similarity
messages: Belongs to the ZC3H14 family.

7227:Dmel CG33287
gene id: 7227:Dmel_CG33287
uniprot id: B7Z095
names: Similarity
messages: Belongs to the DNAI7 family.

7227:Dmel CG8116
gene id: 7227:Dmel_CG8116
uniprot id: Q9VHN0
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG8412
gene id: 7227:Dmel_CG8412
uniprot id: Q9VH78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane

7227:Dmel CG4380
gene id: 7227:Dmel_CG4380
uniprot id: M9PGS2
uniprot id: P20153
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Heterodimer of USP and ECR. Only the heterodimer is capable of high-affinity binding to ecdysone.
messages: Nucleus
messages: Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.

7227:Dmel CG10253
gene id: 7227:Dmel_CG10253
uniprot id: A0A0B4JD21
uniprot id: Q9V778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

7227:Dmel CG9010
gene id: 7227:Dmel_CG9010
uniprot id: Q7JY07
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

7227:Dmel CG12086
gene id: 7227:Dmel_CG12086
uniprot id: Q95RU0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accumulation of spermatocytes with cytoplasmic abnormalities. Early spermatocytes are filled with small, refractile cytoplasmic inclusions, late spermatocytes often contain up to three hook-shaped structures in the cytoplasm. Testes are short with incomplete coiling. The sheath of pigment cells that covers the muscle layer surrounding the testis frequently peels away, particularly from the region near the tip. Female fertility is also reduced, ovaries are small and misshapen.
messages: Belongs to the cueball family.
messages: Cell membrane
messages: Has a role in spermatogenesis and oogenesis (PubMed:8244010). Might have a role in triglyceride homeostasis (PubMed:25409104). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104).

7227:Dmel CG14701
gene id: 7227:Dmel_CG14701
uniprot id: Q9VGQ9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of Dph1, Dph2, Dph3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph1 and Dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising Dph3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in Dph1-Dph2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to Dph1-Dph2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

7227:Dmel CG10993
gene id: 7227:Dmel_CG10993
uniprot id: Q9VY84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

7227:Dmel CG10144
gene id: 7227:Dmel_CG10144
uniprot id: Q9VRX2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aberrant splicing at the N-terminus.
messages: Belongs to the VPS8 family.
messages: Component of the class C core vacuole/endosome tethering (CORVET) complex composed of at least dor/Vps18, Vps16A, Vps8 and car/Vps33A; unlike in other species, Vps11 is not part of the Drosophila complex.
messages: Early endosome
messages: Expressed in the larva, in the pupal wings and the adult fly (at protein level). High levels of expression are found in larval hemocytes and garland nephrocytes (at protein level).
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis.
messages: Semilethal: animals can complete metamorphosis, but most of them die as pharate adults unable to emerge from the pupal case; surviving flies are weak, fail to unfold their wings properly and die within 24 hr. The eye color is similar to wild type flies. In larvae, results in the development of hemocyte-derived melanotic tumors in body cavities, accumulation of crystal cells and lamellocytes and disorganization of the sessile hemocyte compartment which might be connected to the abnormal increase of circulating hemocytes. In garland cells, uptake from the hemolymph, endosome formation and endo-lysosomal trafficking are defective and result in enlarged cells; late endosomes and endolysosomes are fragmented and erroneously distributed in the cytoplasm instead of being found in a layer directly beneath peripheral early endosomes. In hemocytes, acidification of endocytic vacuoles containing bacteria is defective. In wing imaginal disks, there are no endosome defects.

7227:Dmel CG31363
gene id: 7227:Dmel_CG31363
uniprot id: A0A0B4KG85
uniprot id: Q9I7K0
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MAP Jupiter family.
messages: Binds to all microtubule populations.
messages: Cytoplasm
messages: Intron retention.
messages: Nucleus
messages: Ubiquitous expression throughout development. Expressed during cell division in the syncytial embryo. Expressed in developing photoreceptors of the eye imaginal disk of the third larval stage. In adults, highly expressed in neurons of the brain, concentrated in axons. In the adult ovaries, expression accumulates in the germarium and the polar follicular cells as well as in the oocyte along the microtubule network.
messages: cytoskeleton
messages: spindle

7227:Dmel CG6179
gene id: 7227:Dmel_CG6179
uniprot id: A8E752
uniprot id: Q9VWV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
messages: Nucleus

7227:Dmel CG32373
gene id: 7227:Dmel_CG32373
uniprot id: Q8SYF5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8773
gene id: 7227:Dmel_CG8773
uniprot id: Q9VFX0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG9712
gene id: 7227:Dmel_CG9712
uniprot id: Q9VVA7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

7227:Dmel CG1982
gene id: 7227:Dmel_CG1982
uniprot id: O97479
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

7227:Dmel CG32052
gene id: 7227:Dmel_CG32052
uniprot id: Q8IQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Secreted

7227:Dmel CG2187
gene id: 7227:Dmel_CG2187
uniprot id: P91659
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG14290
gene id: 7227:Dmel_CG14290
uniprot id: A0A0B4KHD3
uniprot id: Q7KSC4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.
messages: Viable on standard food, but sensitive to a carbohydrate-only diet, with rapid lethality after transfer to a sucrose medium.

7227:Dmel CG6343
gene id: 7227:Dmel_CG6343
uniprot id: A4V383
uniprot id: P91929
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (PubMed:28683319). Forms a complex including sicily, ND-42 and Hsp83; the complex is necessary to chaperone ND-42 in the cytoplasm before mitochondrial import; the interaction between sicily and ND-42 is direct and occurs preferably between the unprocessed forms in the cytoplasm (PubMed:23509070).
messages: Cytoplasm
messages: Expressed in muscles (at protein level).
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown leads to loss of ND-30 and reduced mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (PubMed:23509070). Larvae exhibit elevated reactive oxygen species (ROS) and an up-regulation of Hsp60 (PubMed:23509070). RNAi-mediated knockdown in the eye results in retinal degeneration exacerbated with aging and accompanied by high levels of ROS and accumulation of lipid droplets in the glia (PubMed:23509070, PubMed:25594180). RNAi-mediated knockdown in neurons results in lipid droplet accumulation and increased levels of peroxidated lipids (PubMed:25594180).

7227:Dmel CG7622
gene id: 7227:Dmel_CG7622
uniprot id: P49630
uniprot id: X2JC35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Cytoplasm
messages: cytosol

7227:Dmel CG10268
gene id: 7227:Dmel_CG10268
uniprot id: Q9VIT2
names: Subcellular Location Annotation
messages: cytosol

7227:Dmel CG5201
gene id: 7227:Dmel_CG5201
uniprot id: Q5U110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG11811
gene id: 7227:Dmel_CG11811
uniprot id: Q9VTB3
names: Similarity
messages: Belongs to the guanylate kinase family.

7227:Dmel CG2984
gene id: 7227:Dmel_CG2984
uniprot id: Q9W4H8
names: Similarity
messages: Belongs to the PP2C family.

7227:Dmel CG34378
gene id: 7227:Dmel_CG34378
uniprot id: Q9VM39
uniprot id: Q9VM40
uniprot id: Q9VM42
uniprot id: X2J909
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7227:Dmel CG33237
gene id: 7227:Dmel_CG33237
uniprot id: Q7KV13
uniprot id: Q9NIV2
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the casein kinase 2 subunit beta family.
messages: In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.
messages: Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
messages: Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.
messages: There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.
messages: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

7227:Dmel CG3723
gene id: 7227:Dmel_CG3723
uniprot id: A0A0B4KHJ4
uniprot id: Q9VDG0
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG7326
gene id: 7227:Dmel_CG7326
uniprot id: Q9VWP0
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

7227:Dmel CG1854
gene id: 7227:Dmel_CG1854
uniprot id: P81917
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
messages: Cell membrane
messages: Expressed with Orco in 20 sensory neurons on the distal edge of the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Involved in the behavioral responses to acetophenone, benzaldehyde, benzyl alcohol, cyclohexanone, and cyclohexanol.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG1381
gene id: 7227:Dmel_CG1381
uniprot id: Q7K1Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

7227:Dmel CG15552
gene id: 7227:Dmel_CG15552
uniprot id: Q9VA17
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG2345
gene id: 7227:Dmel_CG2345
uniprot id: P27780
names: Function
names: Tissue Specificity
messages: Component of the cuticle of the pupa of fruit fly.
messages: Imaginal (anterior) epidermis.

7227:Dmel CG4371
gene id: 7227:Dmel_CG4371
uniprot id: Q9VG93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).
messages: Homodimer.

7227:Dmel CG11926
gene id: 7227:Dmel_CG11926
uniprot id: Q9VR38
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

7227:Dmel CG4083
gene id: 7227:Dmel_CG4083
uniprot id: M9PI82
uniprot id: P91891
names: Similarity
messages: Belongs to the Mo25 family.

7227:Dmel CG34191
gene id: 7227:Dmel_CG34191
uniprot id: A0A0B4LFP4
uniprot id: A8DYH2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with Uba5.
messages: Nucleus
messages: RNAi-mediated knockdown shows aberrant neuromuscular junctions in the larval muscle and abnormal wings, locomotive defects and a shortened lifespan in the adult. RNAi-mediated knockdown in the nervous system results also in aberrant neuromuscular junctions characterized by reduced number of type Ib boutons and increased bouton size in the larval muscle.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation, requires the UFM1-activating E1 enzyme Uba5, the UFM1-conjugating E2 enzyme Ufc1, and the UFM1-ligase E3 enzyme Ufl1 (By similarity). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (By similarity). The Ufm1 cascade might play a role in the development of the neuromuscular junctions (PubMed:26872069).
messages: Ubiquitin-like modifier.

7227:Dmel CG9769
gene id: 7227:Dmel_CG9769
uniprot id: Q9VN50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm

7227:Dmel CG18730
gene id: 7227:Dmel_CG18730
uniprot id: A0A0B4LGS0
uniprot id: P08144
names: Cofactor
names: Polymorphism
names: Similarity
names: Subunit
messages: At least 6 electrophoretic isozymes are known: Amy1, Amy2, Amy3, Amy4, Amy5 and Amy6. Strains J87 and KO123 express Amy2; KO140 and 1420#1 express Amy4; L16 expresses Amy5.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 Cl(-) ion per subunit.
messages: Monomer.

7227:Dmel CG1775
gene id: 7227:Dmel_CG1775
uniprot id: O62609
uniprot id: Q8IMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG3140
gene id: 7227:Dmel_CG3140
uniprot id: Q9U915
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Detected throughout development.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

7227:Dmel CG1438
gene id: 7227:Dmel_CG1438
uniprot id: Q9VA27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG1019
gene id: 7227:Dmel_CG1019
uniprot id: Q24400
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expression is biphasic, peaking late in embryogenesis (16-24 hours embryos) and during the larval to pupal transition, when the musculature is differentiating. Found in developing muscles of the visceral and somatic mesoderm subsequent to the formation of the muscle precursor cells. Decreased levels are still detectable in adults.
messages: In the embryo, expression is restricted to the somatic, visceral, and pharyngeal muscles. Within the somatic musculature, expression is localized at the ends of muscles fibers at the point of attachment to the epidermis (at protein level). There is no expression in cardiac mesoderm or in fat body.
messages: Nucleus
messages: Plays a role in cell differentiation late in myogenesis. Transcription factor Mef2 is essential for expression.

7227:Dmel CG7886
gene id: 7227:Dmel_CG7886
uniprot id: Q9VFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP78 family.
messages: May play a role in cilium biogenesis.
messages: centriole
messages: centrosome
messages: cilium basal body

7227:Dmel CG7422
gene id: 7227:Dmel_CG7422
uniprot id: E1JI63
uniprot id: H0RNK6
uniprot id: H1UUH0
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Detected in the head and to a lesser extent in legs and wings.
messages: Intron retention.
messages: Membrane
messages: Plays an olfactory role that is not restricted to pheromone sensitivity.

7227:Dmel CG1851
gene id: 7227:Dmel_CG1851
uniprot id: Q7JWW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

7227:Dmel CG3735
gene id: 7227:Dmel_CG3735
uniprot id: Q9W1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

7227:Dmel CG42317
gene id: 7227:Dmel_CG42317
uniprot id: Q7KSQ2
uniprot id: Q8INJ8
uniprot id: Q9VGK8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7227:Dmel CG11589
gene id: 7227:Dmel_CG11589
uniprot id: Q9VZG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7227:Dmel CG7194
gene id: 7227:Dmel_CG7194
uniprot id: Q9VSH0
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
messages: Activated in response of some unknown stimulus (PubMed:29924997). Not activated in response to L-monocytogenes infection (PubMed:29924997).
messages: Belongs to the mab-21 family.
messages: Flies display a normal antiviral immune response.
messages: Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus (By similarity). Does not catalyze the formation of cyclic GMP-AMP from ATP and GTP (PubMed:34261128).

7227:Dmel CG4551
gene id: 7227:Dmel_CG4551
uniprot id: I0B8L2
uniprot id: M9PDF9
uniprot id: Q9V3D5
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylates on Tyr-356 and Tyr-358.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Cytoplasm
messages: Deletion within an exon that does not correspond to an intron.
messages: Highly expressed and active during embryogenesis and pupation and at lower levels in larva and adult.
messages: In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation.
messages: Phosphorylated on serine/threonine residues.

7227:Dmel CG11321
gene id: 7227:Dmel_CG11321
uniprot id: Q8IPJ3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the RBR family.
messages: E3 ubiquitin-protein ligase which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response (PubMed:27702987, PubMed:30026495). Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains (PubMed:27702987). Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin-conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains to the substrate key which is essential for activation of the NF-kappa-B signaling cascade in the adult intestinal epithelium (PubMed:27702987, PubMed:30026495). It is not required for systemic immune response to septic infection with either E.carotovora subsp. carotovora 15 or Gram-positive M.luteus bacteria (PubMed:30026495). Function in controlling linear ubiquitination is also essential for regulating the heat stress response in adults. This function may require the E2 ubiquitin-conjugating enzymes Ubc10 or eff (PubMed:27702987).
messages: RNAi-mediated knockdown results in reduced heat tolerance with adults displaying decreased survival upon heat shock. RNAi-mediated knockdown in the muscles results in only a slight decrease in survival upon heat shock, compared to whole-body knockdown.
messages: Strong expression in 10 to 14 hour embryos.
messages: UBA-like 2 (UBA2), but not UBA-like 1 (UBA1), domain interacts with tetra or longer polyubiquitin chains, and di-ubiquitin chains linked via 'lys-63', and to a lesser extent 'lys-48'. However, neither of the UBA1 or UBA2 domains interact with linear 'Met-1'-linked polyubiquitin chains.

7227:Dmel CG34246
gene id: 7227:Dmel_CG34246
uniprot id: A8JNT7
names: Similarity
messages: Belongs to the HscB family.

7227:Dmel CG42386
gene id: 7227:Dmel_CG42386
uniprot id: A3RLR0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: At early stages of embryogenesis, the polycistronic RNA is expressed in seven segmentally separated blastoderm stripes and in a cluster of cells in the anterior part of the embryo (PubMed:17439302). By stage 13 to the end of embryo development, it is expressed in the dorsal trunks, posterior spiracles, pharynx, hindgut and the area which forms the denticle belts (PubMed:17439302). In the leg disk, it is expressed in a ring pattern presumed to be developing tarsal region around 80 to 96 h after egg laying (AEL) and then in the tarsal furrow at the mid-third instar larval stage (PubMed:17439302, PubMed:18801356). Not detected in the tarsal primordium after 100h AEL but is still expressed in a dorsal chordotonal organ of the leg disk (PubMed:17439302). In pupae, expressed broadly throughout the leg disk 0-3 h after puparium formation (APF) but is not detected in this region 6h APF (PubMed:25344753). High expression 4-8 h APF in the presumptive joints between tarsal segments (PubMed:21682860). In the noctum expressed from 40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae, expressed in two anterior stripes and later in the precursors for chemosensory organs (PubMed:21682860). From late third stage instar larvae to early pupal stages, it is also expressed in the wing provein cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In eye disks, expressed in preclusters for presumptive R8 photoreceptors and in a stripe of cells in the posterior region of the disk (PubMed:21682860).
messages: Cytoplasm
messages: Nucleus
messages: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114).
messages: Polycistronic RNA up-regulated by ecdysone.
messages: Simultaneous knockout of tal-1A, tal-2A, tal-3A and tal-AA is embryonic lethal (PubMed:17439302, PubMed:17486114). In embryos chitin secretion and formation of the cuticular exoskeleton appears to be normal (PubMed:17439302, PubMed:17486114). However embryos display a loss of denticle belts and dorsal hairs (PubMed:17439302, PubMed:17486114). Segment-specific epidermal sensory organs are present and segments form normally (PubMed:17439302). The cephalopharyngeal skeleton is lost, and the head skeleton and posterior spiracles are deformed (PubMed:17439302). In the developing leg, tarsal constriction occurs but the tarsal fold does not form (PubMed:17439302). The tracheal system is abnormal displaying a loss of network integrity, an irregular tube diameter and the absence of taenidial folds (PubMed:17439302, PubMed:17486114). Cell packing is not affected, but there is no accumulation of F-actin at the sites of denticle differentiation or formation of F-actin bundles during taenidial development and tracheal tube dilation (stages 14 and 16) (PubMed:17486114). Other F-actin based developmental processes such as filopodia formation of tracheal tip cells, dorsal closure, mitosis or tight packing of denticle cells are unaffected (PubMed:17486114). Denticle and tracheal defects can be rescued by ectopic expression of any one of the four tal peptides (tal-1A, tal-2A, tal-3A and tal-AA) (PubMed:17486114).
messages: This protein is produced by a polycistronic gene which also produces tal-1A, tal-2A and tal-AA from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).

7227:Dmel CG4886
gene id: 7227:Dmel_CG4886
uniprot id: Q9V3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity).

7227:Dmel CG30379
gene id: 7227:Dmel_CG30379
uniprot id: A1Z773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7227:Dmel CG18455
gene id: 7227:Dmel_CG18455
uniprot id: A0A0B4KEE9
uniprot id: Q95RW8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expressed during early development of the head. First expressed in a band around the anterior end of stage 5 blastoderm embryo, at 93% to 85% egg length. By gastrula stage, site of expression shifts to the dorsal-anterior region. At stage 12, expression is found in the clypeolabrum, the stomodaeum, and in ectoderm dorsal to the future supraesophageal ganglion.
messages: Expressed during embryonic development.
messages: May be involved in head or eye development; development of the clypeolabrum and several head sensory organs.
messages: Nucleus

7227:Dmel CG32255
gene id: 7227:Dmel_CG32255
uniprot id: P83297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.
messages: Cell membrane
messages: Expressed in Gr5a-expressing sugar-sensing cells.
messages: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose.

7227:Dmel CG13418
gene id: 7227:Dmel_CG13418
uniprot id: Q9VD81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

7227:Dmel CG12140
gene id: 7227:Dmel_CG12140
uniprot id: Q7JWF1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

7227:Dmel CG17664
gene id: 7227:Dmel_CG17664
uniprot id: A0A0C4DHF9
uniprot id: Q9W1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7227:Dmel CG10602
gene id: 7227:Dmel_CG10602
uniprot id: A4V0U4
uniprot id: Q9VJ39
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

7227:Dmel CG17252
gene id: 7227:Dmel_CG17252
uniprot id: O76857
names: Similarity
messages: Belongs to the BCL7 family.

7227:Dmel CG5625
gene id: 7227:Dmel_CG5625
uniprot id: Q7KVL7
uniprot id: Q9W277
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

7227:Dmel CG6634
gene id: 7227:Dmel_CG6634
uniprot id: Q9VMR2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7227:Dmel CG1842
gene id: 7227:Dmel_CG1842
uniprot id: A0A0B4KI48
uniprot id: E1JJ04
uniprot id: Q9VAV5
names: Similarity
messages: Belongs to the dynein heavy chain family.

7227:Dmel CG5178
gene id: 7227:Dmel_CG5178
uniprot id: B6IDW7
uniprot id: P83967
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abnormalities in Act88F-ifm(3)7 flight muscles result from incorporation of the mutant actin isoform into assembling myofibrils.
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils.
messages: Belongs to the actin family.
messages: Expressed throughout development. Expression is weak during embryonic stages and peaks during larval and pupal stages.
messages: Homozygous mutants are viable and fertile, but fail to form proper IFMs and are flightless. The IFMs of these mutants display mislocalized Smn and Actn.
messages: In Drosophila there are 6 closely related actin genes.
messages: In adult thorax, expressed in the IFMs.
messages: Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
messages: Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
messages: cytoskeleton

7227:Dmel CG3480
gene id: 7227:Dmel_CG3480
uniprot id: Q9W542
names: Similarity
messages: Belongs to the lin-9 family.

7227:Dmel CG3697
gene id: 7227:Dmel_CG3697
uniprot id: Q24087
uniprot id: T2FFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Heterodimer (By similarity). Interacts with hdm.
messages: Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair.
messages: Nucleus

7227:Dmel CG43770
gene id: 7227:Dmel_CG43770
uniprot id: P19339
names: Developmental Stage
names: Domain
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in somatic tissues, but not in the pole cells, which are the precursors of the germline.
messages: Isoform 1 is embryo-specific. Isoform CM1 is male-specific. Isoforms MS3, MS11 and MS16 are female specific. Isoform 1 is expressed for a brief period during the syncytial blastoderm stage. Isoform MS11 is expressed in 4-7 hours embryo.
messages: Part of a complex containing fl(2)d, Sxl and vir (PubMed:12444081). Interacts with nito (PubMed:26324914).
messages: Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated non-functional protein. The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway. The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome.
messages: The Gly-Asn rich domain is required for the cooperative interaction with RNA and for regulating the splicing activity.

7227:Dmel CG8293
gene id: 7227:Dmel_CG8293
uniprot id: Q24307
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IAP family.
messages: Caspase-dependent cleavage is required for suppression of Drice-mediated cell death.
messages: Constitutively expressed (PubMed:17068333). Up-regulated by bacterial lipopolysaccharides (LPS) in Malpighian tubules but not in salivary glands (PubMed:24374974).
messages: Cytoplasm
messages: Expressed in Malpighian tubules from the 3rd instar larval stage and expression continues in pupae and adults with highest levels in adults (at protein level).
messages: Expressed in both principal and stellar cells of the Malphigian tubules.
messages: Interacts with the caspase Strica (PubMed:11550090). Interacts (via BIR2 domain) with rpr and grim (PubMed:18166655). Interacts (via the BIR2 and BIR3 domains) with hid (PubMed:18166655). Interacts (via BIR3 domain) with Drice (PubMed:18166655). Interacts with Dredd; likely to bind Dredd simultaneously with Fadd to form a trimeric complex (PubMed:22549468).
messages: Normal development and viability (PubMed:16894030, PubMed:17068333). Acute sensitivity to infection by Gram-negative bacteria with failure to induce expression of antibacterial peptide genes and inability to mount a proper innate immune response (PubMed:16894030, PubMed:17068333, PubMed:24374974). Loss of cleavage and nuclear translocation of Rel (PubMed:17068333, PubMed:24374974). Increased activity of the effector caspase Drice and increased apoptosis following x-ray irradiation (PubMed:18166655). Reduced ion channel expression in Malpighian tubules (PubMed:24374974).
messages: Nucleus
messages: Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333). Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974). Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468). Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655). Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811). However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333). Plays a role in regulating the expression of ion channels (PubMed:24374974).

7227:Dmel CG6948
gene id: 7227:Dmel_CG6948
uniprot id: E1JI22
uniprot id: Q9VWA1
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin light chain family.
messages: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Expressed throughout development.
messages: There is no evidence of the neuronal splice variant found in vertebrates.
messages: coated pit

7227:Dmel CG15627
gene id: 7227:Dmel_CG15627
uniprot id: E9NA96
uniprot id: M9PC56
uniprot id: Q9VR32
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: In the antenna, detected in neurons of the arista and also detected in sacculus neurons which innervate the first and second chambers (at protein level) (PubMed:21220098, PubMed:19135896, PubMed:27656904). Throughout the main body of the antenna, expressed in neurons which innervate the coeloconic class of olfactory sensilla (at protein level) (PubMed:21220098, PubMed:19135896). Expressed in multiple cells of the dorsal organ including the dorsal organ cool cells (at protein level) (PubMed:27126188, PubMed:27656904). Detected in femur and retina (PubMed:26580016). Expressed in a subset of femur chordonotal neurons and antennal Johnston's Organ neurons (PubMed:26580016).
messages: Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection (PubMed:21220098, PubMed:27161501, PubMed:27656904). Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b (PubMed:21220098). Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27161501, PubMed:27656904). Required in chordonotal organ neurons for behavioral synchronization to low-amplitude temperature cycles and mediates circadian clock resetting by temperature (PubMed:26580016). Together with Ir40a and Ir93a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904).
messages: Interacts with nocte.
messages: Membrane
messages: No visible phenotype (PubMed:21220098). Viable and fertile but their response to environmental cues such as temperature, humidity and odorants is impaired (PubMed:21220098, PubMed:26580016, PubMed:27126188, PubMed:27161501, PubMed:27656904). Response of ac4 coeloconic sensilla neurons to agonist phenylethylamine and of ac2 sensilla neurons to agonist 1,4-diaminobutane is abolished (PubMed:21220098). Response of dorsal organ cool cells to changes in temperature is abolished and consequently larvae fail to avoid cool temperatures (PubMed:27126188, PubMed:27161501, PubMed:27656904). Response of sacculus neurons to changes in humidity is also abolished and consequently larvae fail to move towards their preferred humidity (PubMed:27161501, PubMed:27656904). Failure to synchronize in constant light or constant dark to shallow temperature cycles with an amplitude of 2 degrees Celsius (PubMed:26580016). In constant light, mutants display constant activity throughout the temperature cycle in contrast to controls which show a clear activity peak in the second part of the warm period before and after a 6 hour shift of the temperature cycle (PubMed:26580016). In constant dark, mutants do not shift their evening peak during the temperature cycle in contrast to controls which advance or delay their evening activity peak during phase-advanced or phase-delayed temperature cycles (PubMed:26580016). Barely detectable levels of circadian rhythm protein tim in dorsal neurons DN1 and DN2 (PubMed:26580016). RNAi-mediated knockdown in chordonotal neurons disrupts synchronization of locomotor activity rhythms with temperature cycles (PubMed:26580016).
messages: Perikaryon
messages: axon
messages: cilium
messages: dendrite

7227:Dmel CG12108
gene id: 7227:Dmel_CG12108
uniprot id: Q9W3C7
uniprot id: S5WMX5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Cleaves thioester-linked long fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.
messages: Flies deficient in Ppt1 are viable and fertile, but accumulate abnormal autofluorescent storage material in the adult central nervous system and have a shorter life span.
messages: Lysosome
messages: Ubiquitously expressed.

7227:Dmel CG7853
gene id: 7227:Dmel_CG7853
uniprot id: Q9VVD9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Expressed both maternally and zygotically. Also expressed at lower levels later in embryonic development, and in larvae and adults.
messages: Golgi apparatus membrane
messages: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS).

7227:Dmel CG1555
gene id: 7227:Dmel_CG1555
uniprot id: A1Z746
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: A mutation exists in the sequenced strain which affects the 3' end of the sequence.
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Membrane
messages: Mitochondrion

7227:Dmel CG3991
gene id: 7227:Dmel_CG3991
uniprot id: Q9V6K1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide.
messages: Cytoplasm
messages: Homooligomer; forms a complex of 6 MDa probably composed of 40 subunits. Forms a structure consisting of 2 segmented and twisted strands that form a spindle-shaped structure. Each strand is composed of 10 segments (a segment being a homodimer oriented head to head), stacking of these segments leads to the formation of a twisted single strand. 2 strands compose the fully assembled spindle.
messages: Inhibited by phenylmethanesulfonyl fluoride (PMSF) and butabindide, but not by peptidase inhibitor pepstatin, EDTA, nor bestatin.
messages: The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-399 and Glu-430 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (PubMed:20676100).

7227:Dmel CG4320
gene id: 7227:Dmel_CG4320
uniprot id: Q9W437
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

7227:Dmel CG9078
gene id: 7227:Dmel_CG9078
uniprot id: Q94515
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Has sphingolipid-delta-4-desaturase activity. Converts sphinganine-containing sphingolipids (such as N-acylsphinganines or dihydroceramides) into sphingolipids containing the delta-4-desaturated sphingoid base (E)-sphing-4-enine (such as N-acylsphing-4-enines or ceramides), which are required for many different functions (structural functions as well as signaling) (PubMed:11937514). Required to initiate spermatid differentiation among other signals (PubMed:9003299). Required for central spindle assembly and cytokinesis during male meiosis, may act as part of an anchoring mechanism that links membrane-bounded cellular compartments to components of the cytoskeleton (PubMed:9819060).
messages: Membrane
messages: Mitochondrion
messages: Primary spermatocytes become mature in size but degenerate without initiating meiotic chromosome condensation in their nuclei. The mutation does not affect female fertility but leads to semi-lethality both in males and females during embryonic stages (PubMed:9003299). Homozigous mutant spermatids show a misshapen Nebenkern, which varies in size and is associated with multiple nuclei (PubMed:9819060).
messages: Testes.

7227:Dmel CG8107
gene id: 7227:Dmel_CG8107
uniprot id: M9NE73
uniprot id: Q9VT65
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by millimolar concentrations of calcium.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Expressed in all developmental stages, with highest expression in the egg, probably of maternal origin. Very low expression in the early larva, rising through larval development up to the third larval stage. Constant expression in the pupa and adult.
messages: Membrane
messages: Strongly expressed in follicular and border cells of the oocyte. Ubiquitously expressed in early embryos. Localized to the trachea and their orifices, and to the larynx of late embryos. Restricted to the salivary gland in third instar larvae.
messages: Undergoes calcium-dependent autolytic cleavage between Asn-74 and Ala-75 and between Gln-224 and Asn-225 to produce two major products, calpain B catalytic subunit 1 and calpain B catalytic subunit 2. This autolysis is necessary for activation of the protein.

7227:Dmel CG3666
gene id: 7227:Dmel_CG3666
uniprot id: A1ZAC0
names: Function
names: Similarity
messages: Belongs to the transferrin family.
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

7227:Dmel CG33151
gene id: 7227:Dmel_CG33151
uniprot id: D8FT26
uniprot id: Q9W1N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons. In larvae, is expressed in neurons of the terminal external chemosensory organ.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG6674
gene id: 7227:Dmel_CG6674
uniprot id: M9PHY9
uniprot id: Q9VT74
names: Similarity
messages: Belongs to the TSSC4 family.

7227:Dmel CG8034
gene id: 7227:Dmel_CG8034
uniprot id: Q7K0I7
uniprot id: Q9VWJ1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1577
gene id: 7227:Dmel_CG1577
uniprot id: A0A1B2AJ61
uniprot id: Q7JWG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG14213
gene id: 7227:Dmel_CG14213
uniprot id: M9PF85
uniprot id: Q7JVP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

7227:Dmel CG6910
gene id: 7227:Dmel_CG6910
uniprot id: M9PI33
uniprot id: Q9VTU9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

7227:Dmel CG7616
gene id: 7227:Dmel_CG7616
uniprot id: Q9VTG5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

7227:Dmel CG3152
gene id: 7227:Dmel_CG3152
uniprot id: A1Z6L9
names: Similarity
messages: Belongs to the heat shock protein 90 family.

7227:Dmel CG9099
gene id: 7227:Dmel_CG9099
uniprot id: Q9VX98
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Animals die as pharate adults with crooked legs, abnormal genitalia and a larval-like epidermis. Proliferation of histoblast cells is impaired.
messages: Belongs to the DENR family.
messages: Interacts with MCTS1.
messages: Regulates translation as part of a complex with MCTS1. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR.

7227:Dmel CG42708
gene id: 7227:Dmel_CG42708
uniprot id: A0A0B4LF95
uniprot id: A0A0B4LGA3
uniprot id: A1Z942
uniprot id: A1Z943
uniprot id: A1Z944
uniprot id: E1JH47
uniprot id: Q0E9A1
uniprot id: Q1RL13
uniprot id: Q7JQK6
uniprot id: Q961I1
names: Similarity
messages: Belongs to the glutaminase family.

7227:Dmel CG11804
gene id: 7227:Dmel_CG11804
uniprot id: Q7JUY7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ced-6 family.
messages: Cytoplasm
messages: Detected in brain cells adjacent to the mushroom body. Expression is low in wandering larvae, elevated 6 hours after puparium formation and back to low levels 12 hours after puparium formation. Detected in infiltrating processes of a subset of glial cells adjacent to mushroom body dorsal lobes.
messages: Embryonic hemocytes display a reduced level of apoptotic cell phagocytosis (PubMed:19927123). Larval hemocytes display reduced bacterial phagocytosis (PubMed:19890048). RNAi-mediated knockdown in muscle leads to an increase in the number of ghost synaptic boutons but does not affect the deposition of presynaptic debris while RNAi-mediated knockdown in glia leads to a significant increase in presynaptic debris deposition but does not affect the number of ghost boutons (PubMed:19707574).
messages: May interact with Drpr.
messages: Plays a role in axon pruning in larval mushroom body neurons during metamorphosis (PubMed:16772168). Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches (PubMed:16772168). Involved in Drpr-mediated phagocytosis of apoptotic cells (PubMed:19927123). Required for bacterial phagocytosis (PubMed:19890048). During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth (PubMed:19707574).

7227:Dmel CG1303
gene id: 7227:Dmel_CG1303
uniprot id: O76339
names: Similarity
messages: Belongs to the MGMT family.

7227:Dmel CG1560
gene id: 7227:Dmel_CG1560
uniprot id: P11584
uniprot id: X2JAU0
uniprot id: X2JE30
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the integrin beta chain family.
messages: Heterodimer of an alpha and a beta subunit. Beta-PS associates with either alpha-PS1, alpha-PS2, alpha-PS3, alpha-PS4 or alpha-PS5.
messages: In ovaries, strongly expressed in follicle cells (PubMed:19035354). In oocytes, expressed in the forming dorsal appendages (at protein level) (PubMed:19035354). Expressed in the embryonic dorsal cuticle, the larval eye and the wing imaginal disk (PubMed:8119134). In testes, detected at the interface between somatic hub cells and cyst stem cells (PubMed:27191715).
messages: In zygotic mutant embryos, midgut forms primary constrictions but fails to elongate and the visceral muscle does not flatten but remains attached to the midgut epithelium. Embryos lacking maternal and zygotic mys show a delay in midgut migration. Mutant larvae present an olfactory phenotype, showing reduced response to isoamyl acetate but normal response to ethyl acetate.
messages: Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082). Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786). Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969). Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969). The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969). Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969). Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184). Involved in the function and/or development of the olfactory system (PubMed:10821184). In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715). Plays a role in timely border cell migration during oogenesis (PubMed:19035354).
messages: Lateral cell membrane
messages: Membrane
messages: The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.

7227:Dmel CG12038
gene id: 7227:Dmel_CG12038
uniprot id: Q7KVC9
names: Similarity
messages: Belongs to the DIPK family.

7227:Dmel CG7074
gene id: 7227:Dmel_CG7074
uniprot id: Q9VQ89
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:21521741, PubMed:25512509, PubMed:14973288, PubMed:23723238). This component is required for activating TORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate (PubMed:27166823, PubMed:21521741, PubMed:23723238). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:21521741, PubMed:25512509, PubMed:14973288, PubMed:23723238). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the TORC1 complex, functions independently of TORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823).
messages: Belongs to the WD repeat mio family.
messages: Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with Wdr24 (PubMed:27166823). Interacts with nucleoporin Nup44A/Seh1 (PubMed:21521741).
messages: Egg chambers contain 16 polyploid nurse cells because the oocyte enters the endocycle and develops as a polyploid nurse cell.
messages: Lysosome
messages: Nucleus
messages: Present in the oocyte.

7227:Dmel CG1749
gene id: 7227:Dmel_CG1749
uniprot id: Q9VYY3
uniprot id: T1W131
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which activates UFM1.
messages: Golgi apparatus
messages: Interacts (via C-terminus) with Ufc1. Interacts with Ufm1.
messages: Nucleus
messages: RNAi-mediated knockdown shows aberrant neuromuscular junctions in the larval muscle and abnormal wings, locomotive defects and a shortened lifespan in the adult fly. RNAi-mediated knockdown in the nervous system results also in aberrant neuromuscular junctions characterized by reduced number of type Ib boutons and increased bouton size in the larval muscle.

7227:Dmel CG42503
gene id: 7227:Dmel_CG42503
uniprot id: P0C919
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with Mocs2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (Mocs2A) and 2 large (Mocs2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (Mocs2B).

7227:Dmel CG10685
gene id: 7227:Dmel_CG10685
uniprot id: A0A1B2AKR4
uniprot id: M9PBD6
uniprot id: M9PG66
uniprot id: Q9VIZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
messages: Nucleus

7227:Dmel CG5780
gene id: 7227:Dmel_CG5780
uniprot id: Q9VK67
names: Similarity
messages: Belongs to the IFT43 family.

7227:Dmel CG2960
gene id: 7227:Dmel_CG2960
uniprot id: P18101
uniprot id: Q7JYK1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 60S ribosomal protein is part of the 60S ribosomal subunit.
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: For a better understanding, features related to ubiquitin are only indicated for the first chain.
messages: In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

7227:Dmel CG18788
gene id: 7227:Dmel_CG18788
uniprot id: Q9I7N1
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4591
gene id: 7227:Dmel_CG4591
uniprot id: A0A0B4KFQ5
uniprot id: Q9VGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG1208
gene id: 7227:Dmel_CG1208
uniprot id: A8JQU1
uniprot id: Q8T0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG13920
gene id: 7227:Dmel_CG13920
uniprot id: Q8T0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

7227:Dmel CG31019
gene id: 7227:Dmel_CG31019
uniprot id: A0A0B4KI64
uniprot id: Q8IMH9
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG2637
gene id: 7227:Dmel_CG2637
uniprot id: M9NDC3
uniprot id: O18388
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Forms a complex with an importin alpha subunit (By similarity). Interacts with the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731).
messages: Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins (PubMed:11102382). In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126).
messages: Ubiquitously expressed in embryos.

7227:Dmel CG10838
gene id: 7227:Dmel_CG10838
uniprot id: Q9VQA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

7227:Dmel CG7583
gene id: 7227:Dmel_CG7583
uniprot id: A0A0B4KFT4
uniprot id: A0A0B4KFX5
uniprot id: A0A0B4KGG9
uniprot id: A0A0B4KGZ7
uniprot id: A0A0B4KHB2
uniprot id: A4V2S3
uniprot id: O46036
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.
messages: Expressed both maternally and zygotically. Zygotic expression is highest in pupae.
messages: Homodimer. Interacts with hairy (h), knirps (kni), snail (sna), and Enhancer of split m-delta (HLHm-delta). Complex may be involved in transcriptional repression. Interacts also with adenovirus E1A protein.
messages: Nucleus

7227:Dmel CG5171
gene id: 7227:Dmel_CG5171
uniprot id: C9QPE7
uniprot id: Q9VM19
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

7227:Dmel CG1167
gene id: 7227:Dmel_CG1167
uniprot id: P04388
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems.
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with hzg.
messages: May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

7227:Dmel CG18495
gene id: 7227:Dmel_CG18495
uniprot id: E1JGZ9
uniprot id: Q9XZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG6713
gene id: 7227:Dmel_CG6713
uniprot id: Q27571
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Catalyzes the conversion of L-arginine to L-citrulline producing nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7568075, PubMed:12804606). Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full-length protein and serve as dominant negative inhibitors of the enzyme activity.
messages: Isoform 3 is expressed in larvae only. Isoform 4, isoform 5, isoform 6 and isoform 10 are expressed throughout development from embryos to adults.
messages: Stimulated by calcium/calmodulin.

7227:Dmel CG6178
gene id: 7227:Dmel_CG6178
uniprot id: Q9VCC6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG4214
gene id: 7227:Dmel_CG4214
uniprot id: A4V0S1
uniprot id: Q24509
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Homodimer.
messages: Mediates endoplasmic reticulum to Golgi transport.
messages: Membrane
messages: cis-Golgi network membrane

7227:Dmel CG6521
gene id: 7227:Dmel_CG6521
uniprot id: Q9XTL2
names: Similarity
messages: Belongs to the STAM family.

7227:Dmel CG15880
gene id: 7227:Dmel_CG15880
uniprot id: Q9VPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

7227:Dmel CG7720
gene id: 7227:Dmel_CG7720
uniprot id: Q7K3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7227:Dmel CG30428
gene id: 7227:Dmel_CG30428
uniprot id: A0A0B4LGM2
uniprot id: Q8MLN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Nucleus
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG17264
gene id: 7227:Dmel_CG17264
uniprot id: Q9VQK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG9308
gene id: 7227:Dmel_CG9308
uniprot id: Q9W2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

7227:Dmel CG30418
gene id: 7227:Dmel_CG30418
uniprot id: Q9W192
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds heparin (PubMed:35609633). Interacts with dally; the interaction promotes dally degradation (PubMed:35609633). Interacts with dpp and gbb (PubMed:35037619).
messages: Expressed in the wing disks and wing veins, possibly on the surface of hemocytes (at protein level) (PubMed:35609633). Expressed during third-instar larval stage in wing disks in a stripe of cells at the anterior-posterior (A/P) compartment boundary, in the epithelial folds located in the central part of the wing pouch but with diminished expression along the dorsoventral (D/V) boundary (at protein level) (PubMed:35609633, PubMed:35037619). In pupal wings at 24 hrs, after puparium formation (APF), detected in a row of distal anterior cells (at protein level) (PubMed:35609633, PubMed:35037619).
messages: Secreted
messages: Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways (PubMed:35609633, PubMed:35037619). In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling (PubMed:35609633, PubMed:35037619). In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment (PubMed:35609633, PubMed:35037619). Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells (PubMed:35609633, PubMed:35037619). During wing development regulates dpp/BMP coreceptor dally availability on the cell surface (PubMed:35609633). Might have a role in testis development (PubMed:35609633).
messages: extracellular matrix

7227:Dmel CG3496
gene id: 7227:Dmel_CG3496
uniprot id: Q9W1R5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:11156988, PubMed:27919077). M6A methylation is also required for neuronal functions (PubMed:27919077). Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174).
messages: Belongs to the vir family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077,PubMed:29535189, PubMed:29555755). Part of a complex containing fl(2)d, Sxl and vir (PubMed:12444081).
messages: Nucleus
messages: Ubiquitously expressed in males and females throughout embryogenesis (PubMed:11156988, PubMed:27919077). Expression levels decrease from gastrulation toward late embryogenesis (PubMed:11156988). Enriched in the neuroectoderm at later stages (PubMed:27919077).

7227:Dmel CG11604
gene id: 7227:Dmel_CG11604
uniprot id: Q9VPM5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Detected in male and female third instar larvae with very low levels detected in adults (at protein level).
messages: Lethality around pupal formation with rare escapers with a delayed eclosion time (PubMed:24615015). Reduced size of neuroblasts and ganglion mother cells with no effect on cell size in wing imaginal disks (PubMed:24615015). Grossly reduced mushroom bodies with degeneration of Kenyon cells (PubMed:15375215).
messages: May be phosphorylated in vivo by CkIIalpha. mbm and CkIIalpha colocalize to the nucleolus and mbm is phosphorylated in vitro by CkIIalpha.
messages: Required for small ribosomal subunit biogenesis in neuroblasts (PubMed:24615015). Plays a role in mushroom body development (PubMed:15375215).
messages: Shows widespread expression in third instar larval brain with no apparent difference between males and females (at protein level). Detected at low levels in the mushroom body neuropil and is also expressed in many cells of the brain outside the mushroom body (at protein level). Not detected in third instar larval brain cells in anaphase (at protein level).
messages: nucleolus

7227:Dmel CG6205
gene id: 7227:Dmel_CG6205
uniprot id: M9PF43
uniprot id: Q9VWV9
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically.
messages: Interacts with wg and Wnt5.
messages: Membrane
messages: Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of Wnt proteins is required for efficient binding to frizzled receptors (By similarity). Also facilitates the glycosylation of Wnt family members, including wg and Wnt5. The cotranslational disulfide bond formation of wg competes with the N-glycosylation. Porc stimulates the post-translational N-glycosylation by anchoring wg at the ER membrane, probably through acylation (PubMed:11821428, PubMed:15166250, PubMed:22108505, PubMed:8985181).
messages: Was initially thought to mediate palmitoylation of Wnt proteins. It was later shown that instead it acts as a serine O-palmitoleoyltransferase that mediates the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins.

7227:Dmel CG6623
gene id: 7227:Dmel_CG6623
uniprot id: Q9VFB7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMEM1 family.
messages: Co-expressed with Shal in the nervous system.
messages: Expressed throughout development from 5 hours after egg laying though to adults.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Has a role in one of the several mechanisms underlying dendritic localization of Shal channels.
messages: Part of the multisubunit TRAPP (transport protein particle) complex (By similarity). Interacts with Shal (via C-terminal dendritic targeting motif).
messages: Perikaryon
messages: cis-Golgi network
messages: dendrite

7227:Dmel CG7788
gene id: 7227:Dmel_CG7788
uniprot id: O01382
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Expressed at all stages where apoptosis occurs.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Dronc and Drice can form a stable complex (PubMed:10675329). Interacts with Diap2 (via BIR3 domain) to form a stable complex (PubMed:18166655).
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.

7227:Dmel CG7708
gene id: 7227:Dmel_CG7708
uniprot id: Q9VE46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity).
messages: Membrane

7227:Dmel CG6984
gene id: 7227:Dmel_CG6984
uniprot id: Q7K1C3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7227:Dmel CG18001
gene id: 7227:Dmel_CG18001
uniprot id: A0A0B4KED0
uniprot id: Q9W5N2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

7227:Dmel CG2577
gene id: 7227:Dmel_CG2577
uniprot id: Q9VYN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG7600
gene id: 7227:Dmel_CG7600
uniprot id: Q9XZ12
names: Similarity
messages: Belongs to the FAM91 family.

7227:Dmel CG6835
gene id: 7227:Dmel_CG6835
uniprot id: Q86B44
uniprot id: Q8IQZ1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

7227:Dmel CG10849
gene id: 7227:Dmel_CG10849
uniprot id: Q9VZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG10481
gene id: 7227:Dmel_CG10481
uniprot id: Q7KT29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

7227:Dmel CG2902
gene id: 7227:Dmel_CG2902
uniprot id: Q24418
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Expression first seen in late embryos. Levels are low during larval development and increase in late pupae to persist through to adulthood.
messages: Flies exhibit disruption of olfactory learning.
messages: Forms a heteromeric NMDA channel with Nmdar2.
messages: Highly expressed in adult heads: in the brain and ring gland. Low expression throughout the entire brain is also seen. Higher expression levels were observed in some scattered cell bodies and part of their fibers, including those from several pairs of DPM (dorsal-posterior-medial) neurons surrounding the calyx, DAL (dorsal-anterior-lateral) and DPL (dorsal-posterior-lateral) neurons in the lateral protocerebrum (LP), VAL (ventral-anterior-lateral) neurons in the anterior protocerebrum, and two pairs of VP (ventral-posterior) neurons in the posterior protocerebrum. Many cell bodies in the optic lobes show preferential expression. Punctuate expression is notably detected in many brain regions including the superior medial protocerebrum. Weakly expressed in the antennal lobes and central complex.
messages: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.
messages: Postsynaptic cell membrane
messages: Postsynaptic density

7227:Dmel CG1865
gene id: 7227:Dmel_CG1865
uniprot id: A1Z6V5
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG12559
gene id: 7227:Dmel_CG12559
uniprot id: P40417
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-198 and Tyr-200, which activates the enzyme (By similarity). Phosphorylated on tyrosine residue(s) in response to insulin.
messages: Embryonic wound healing defects (PubMed:22140578). RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage and increases adult weight (PubMed:19965758).
messages: Embryos, larvae and adults.
messages: In third instar larvae, expressed in eye imaginal disks. In adults, expressed in head and body.
messages: Nucleus
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate proliferation, differentiation and effect cell fate decisions in various tissues (PubMed:8157002, PubMed:19965758, PubMed:22140578, PubMed:27552662). Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways (PubMed:8157002). Required for embryonic epithelial tissue repair (PubMed:22140578). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

7227:Dmel CG10612
gene id: 7227:Dmel_CG10612
uniprot id: Q9VNB3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, ethyl acetate, and propyl acetate.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG17903
gene id: 7227:Dmel_CG17903
uniprot id: P84029
uniprot id: X2J6D4
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Expressed at varying, but relatively high levels throughout development.
messages: Mitochondrion intermembrane space
messages: There are two cytochrome C genes in Drosophila: Cyt-c-d (distal) and Cyt-c-p (proximal).

7227:Dmel CG43321
gene id: 7227:Dmel_CG43321
uniprot id: M9NEV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG6692
gene id: 7227:Dmel_CG6692
uniprot id: A0A0B4JD48
uniprot id: Q95029
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Dimer of a heavy and a light chain linked by disulfide bonds.
messages: Expressed in embryo, larva, pupa and adult.
messages: Flies exhibit wing and pigmentation defects. Females are sterile, males are partially sterile.
messages: Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion.
messages: In the embryo, predominantly expressed in the midgut. Also expressed in larval alimentary organs such as salivary gland and midgut including gastric caeca.
messages: Intron retention.
messages: Lysosome

7227:Dmel CG14006
gene id: 7227:Dmel_CG14006
uniprot id: Q9VMN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

7227:Dmel CG42564
gene id: 7227:Dmel_CG42564
uniprot id: Q9VI17
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5166
gene id: 7227:Dmel_CG5166
uniprot id: A0A0B4LH64
uniprot id: Q8SWR8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ataxin-2 family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Zygotic expression is seen in third larval instar, pupae, and adults.
messages: Homodimer (PubMed:28388438). In the circadian pacemaker neurons, core component of the Atx2-tyf activator complex composed of at least Atx2, tyf, pAbp, Lsm12a (PubMed:28388438). In the circadian pacemaker neurons, also a core component of the Atx2-Not1 repressor complex composed of at least Atx2, tyf, pAbp, me31B (PubMed:28388438). Interacts (via PAM2 motif) with pAbp (PubMed:28388438). Interacts (via N-terminus) with tyf independently of pAbp (PubMed:28388438). Forms a subcomplex composed of Atx2 and pAbP which can associate with the 5' cap of pre-mRNAs independently of tyf, Lsm12a or me31B (PubMed:28388438). Interacts with Lsm12a and me31B (PubMed:28388438).
messages: Partially edited. Target of Adar.
messages: Potential poly-A sequence.
messages: RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation (PubMed:12524342, PubMed:28388438). Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B (PubMed:28388438). Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors (PubMed:28388438). Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). Regulates actin filament formation, though it does not directly assemble with actin filaments (PubMed:12524342). Required for oocyte specification and oocyte positioning in the female germline (PubMed:12524342). Also required for normal eye development and bristle morphology (PubMed:12524342).
messages: Second instar larvae lethal.
messages: The PAM2 motif, and therefore interaction with pAbp, is essential for binding to the 5' cap of pre-mRNAs.

7227:Dmel CG42522
gene id: 7227:Dmel_CG42522
uniprot id: Q7KTH8
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Essential component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.
messages: Expressed maternally and zygotically throughout development.
messages: Nucleus
messages: Probable component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
messages: The PCI domain is necessary and sufficient for interactions with other CSN subunits of the complex.

7227:Dmel CG6524
gene id: 7227:Dmel_CG6524
uniprot id: P07186
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chorion protein S19 family.
messages: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
messages: Secreted

7227:Dmel CG2082
gene id: 7227:Dmel_CG2082
uniprot id: A0A0B4K6A1
uniprot id: E1JJ55
uniprot id: E1JJ59
uniprot id: E1JJ60
uniprot id: Q59E07
uniprot id: Q8IPR0
uniprot id: Q95T61
uniprot id: Q9VNH7
uniprot id: Q9Y164
names: Similarity
messages: Belongs to the NDRG family.

7227:Dmel CG11139
gene id: 7227:Dmel_CG11139
uniprot id: Q7K3Z3
names: Subcellular Location Annotation
messages: Golgi stack

7227:Dmel CG1354
gene id: 7227:Dmel_CG1354
uniprot id: E6PBV6
uniprot id: Q8SWU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

7227:Dmel CG30263
gene id: 7227:Dmel_CG30263
uniprot id: A0A0B4KGB1
uniprot id: A0A126GUQ1
uniprot id: Q9W2E1
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPEC3 family. Stum subfamily.
messages: Expressed in limited populations of proprioceptive neurons that sense a mechanical property of specific joints. In the legs, localizes to 3 labeled neurons: one at the femur-tibia joint, the second at the tibia-tarsus joint, and the third spanning the second tarsal segment. Dendrites of stum-expressing neurons in legs are stretched by both flexion and extension of corresponding joints.
messages: Impaired walking characterized by walking uncoordination and reduced climbing speed. Type I neurons are apparently unaffected. Abolition of responses to stretching: although the dendritic stretching is not significantly affected, the Ca(2+) responses to both acute and obtuse joint angles are abolished in the mutant. Axons and cell bodies are indistinguishable from controls, while the sensory dendrite exhibit abnormalities: in some of the stum-expressing neurons the tip of the dendrite is overgrown and extended into the distal segment of the joint. Expression of the mouse ortholog (AC Q0VBF8) in mutant flies rescues the phenotype.
messages: Membrane
messages: Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels.
messages: Was named stumble because of the walking impairment phenotype.
messages: dendrite

7227:Dmel CG10336
gene id: 7227:Dmel_CG10336
uniprot id: Q8INX3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: By E2f.
messages: Cytoplasm
messages: Nucleus
messages: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity).

7227:Dmel CG7843
gene id: 7227:Dmel_CG7843
uniprot id: A0A0B4KEI5
uniprot id: Q9V9K7
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha.
messages: Belongs to the ARS2 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Interacts with cbp20, Dcr-2 and pasha.
messages: Lethality.
messages: Nucleus

7227:Dmel CG4423
gene id: 7227:Dmel_CG4423
uniprot id: Q9VG94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).
messages: Homodimer.

7227:Dmel CG16728
gene id: 7227:Dmel_CG16728
uniprot id: Q95RG8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Detected muscle syncytia in embryonic stage 14 and early stage 15. At mid stage 15, localizes at the leading edge of growing myotubes. In the ventral ends of VO5 and VO6 muscles enriched at the base of membrane protrusions at the leading edge of growing myotubes, while it is less expressed in filopodia. In the late stage embryo, concentrated at all muscle attachment sites, although subtle variation in expression and/or localization may be observed in different muscles subsets. Remains enriched in myotubes until the end of embryogenesis (at protein level).
messages: Expressed in embryonic muscle syncytia (at protein level).
messages: GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through Pak activation, may positively regulate microtubule nucleation during interphase. May play a role in the regulation of cytokinesis (By similarity). During embryogenesis, promotes proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes (PubMed:18996366). Required for the recruitment of Pak to muscle attachments in the embryo, probably indirectly through pix/dPIX (PubMed:18996366). May be important for brain development (PubMed:25792865).
messages: Homozygous knockout flies show a semi-lethal phenotype and exhibit defective wing morphology at 100% penetrance (PubMed:18996366). Mutant embryos show striking guidance phenotypes in ventral oblique muscle 5 (VO5) and ventral oblique muscle 6 (VO6), characterized by bypass and mistargeting of the mutant muscles toward the ventral midline. Defects in targeting of the growing ventral tips of mutant muscles toward the ventral midline are already detectable at late stage 14/early stage 15 embryos. Defects in other ventral muscles are less obvious, although ventral acute muscle 3 (VA3) occasionally show mistargeting toward the ventral midline (PubMed:18996366). Defects in number and shape of subsets of muscles are also observed, but at low frequency (PubMed:18996366). Adult knockout flies show decreased central brain size and abnormal morphology of the mushroom body, the most common pattern being early termination of one alpha-lobe. The penetrance of the impaired mushroom body development is incomplete (PubMed:25792865).
messages: May form homodimers (via coiled coil) (By similarity). Forms a complex with pix and Pak; the interaction with Pak may be indirect and mediated by pix/dPIX (PubMed:18996366).
messages: Synapse
messages: The coiled coil region may mediate dimerization.
messages: centrosome
messages: focal adhesion
messages: lamellipodium
messages: spindle pole

7227:Dmel CG3134
gene id: 7227:Dmel_CG3134
uniprot id: Q24434
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Essential for proper maintenance of sister-chromatid cohesion in both male and female meiosis. Mutations in ord cause premature separation of the sister chromatids in meiosis I and random segregation in both meiotic divisions. Required for chiasma maintenance in female meiosis. Mutations in ord reduce recombination in female meiosis.
messages: Interacts with Sce.
messages: Nucleus
messages: centromere

7227:Dmel CG32795
gene id: 7227:Dmel_CG32795
uniprot id: A4V3W8
uniprot id: Q9U1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane

7227:Dmel CG12502
gene id: 7227:Dmel_CG12502
uniprot id: M9NDE4
uniprot id: Q9W0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

7227:Dmel CG5195
gene id: 7227:Dmel_CG5195
uniprot id: Q9VPF0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: During embryonic stage 16-17, expressed in accessory cells of all ciliated mechanosensory and chemosensory organs (at protein level). Specifically, detected in the cap cell of chordotonal organs and the shaft cell of external sensory organs (at protein level). Also detected in chemosensory organs including the pharyngeal organs, dorsal organ, terminal organ and ventral organ (at protein level). Expression appears to be temporally restricted to late embryogenesis and is not detected during larval stages (at protein level).
messages: Required for normal morphology and function of ciliated sensory organs.
messages: Viable and fertile. Larval locomotion is severely uncoordinated and the chemotactic response to sucrose is reduced. Morphology of the lch5 mechanosensory organ is abnormal, with disorganized cilia and neuronal cell bodies, although cilia still make contact with the cap cell.
messages: extracellular matrix

7227:Dmel CG2056
gene id: 7227:Dmel_CG2056
uniprot id: Q7K3Y1
names: Similarity
messages: Belongs to the peptidase S1 family. CLIP subfamily.

7227:Dmel CG3851
gene id: 7227:Dmel_CG3851
uniprot id: P23803
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Has two temporally distinct modes of expression during early embryogenesis; expressed in seven stripes at the blastoderm stage, then during gastrulation the seven primary stripes are supplemented by secondary stripes which appear in alternate segments. This results in the labelling of every segment in the extended germ band. Also expressed in the embryo in distinct regions of the gut, the Garland cells associated with the proventriculus, the pericardial cells, the lymph glands associated with the heart, in a subset of cells in the central nervous system and in select apodemes. Expressed in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4.
messages: Nucleus
messages: Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions. May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.

7227:Dmel CG14740
gene id: 7227:Dmel_CG14740
uniprot id: Q95TZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

7227:Dmel CG12913
gene id: 7227:Dmel_CG12913
uniprot id: A1Z863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7227:Dmel CG10419
gene id: 7227:Dmel_CG10419
uniprot id: Q9VVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Expressed in nurse cells and oocytes.
messages: Part of the core SMN complex, at least composed of Smn and Gem2. The SMN complex associates with the entire set of spliceosomal snRNP Sm proteins, SmB, SmD1, SmD2, SmD3, SmE, SmF and SmG, and with the snRNP-specific proteins snRNP-U1-70K, U2A, snf/U1A and U5-116KD.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18621711, PubMed:23333303). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).

7227:Dmel CG42396
gene id: 7227:Dmel_CG42396
uniprot id: Q9V4M2
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: 'Wech' means 'detached' or 'gone' in German.
messages: Expressed both maternally and zygotically throughout development.
messages: Expressed ubiquitously in all epithelial cells during early stages of embryogenesis. Specifically expressed at epidermal muscle attachment site.
messages: Interacts with the head domain of rhea and the kinase domain of Ilk.
messages: Muscle detachment in late-stage-16/early-stage-17 embryos.
messages: Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites.
messages: Was originally termed dappled.

7227:Dmel CG17192
gene id: 7227:Dmel_CG17192
uniprot id: Q9VB92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG10406
gene id: 7227:Dmel_CG10406
uniprot id: Q9VEV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

7227:Dmel CG5939
gene id: 7227:Dmel_CG5939
uniprot id: P35415
uniprot id: P35416
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paramyosin family.
messages: Expressed in all larval and adult muscle tissues. Expression is five times higher in tubular than in fibrillar muscles.
messages: Found in all adult muscle tissues except in indirect flight muscles and a set of temporary abdominal muscles. Not detected in larval muscle.
messages: Heterodimer of two isoforms.
messages: Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
messages: Phosphorylated.
messages: The more-acidic and less-abundant isoform is phosphorylated.
messages: Undetectable during gastrulation and early phases of germ band formation. Increases during organogenesis, around 10 hours post-fertilization (hpf), to the adult stage.
messages: myofibril

7227:Dmel CG5418
gene id: 7227:Dmel_CG5418
uniprot id: Q9VK81
names: Similarity
messages: Belongs to the IUNH family.

7227:Dmel CG8196
gene id: 7227:Dmel_CG8196
uniprot id: A0A0B4LEH6
uniprot id: A1Z7M8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

7227:Dmel CG30150
gene id: 7227:Dmel_CG30150
uniprot id: Q8MMF9
names: Function
names: Similarity
messages: Belongs to the PBP/GOBP family.
messages: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.

7227:Dmel CG1228
gene id: 7227:Dmel_CG1228
uniprot id: Q9W0R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

7227:Dmel CG9270
gene id: 7227:Dmel_CG9270
uniprot id: Q7KT22
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG17010
gene id: 7227:Dmel_CG17010
uniprot id: Q9VK96
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

7227:Dmel CG34132
gene id: 7227:Dmel_CG34132
uniprot id: Q0E8V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

7227:Dmel CG1708
gene id: 7227:Dmel_CG1708
uniprot id: A0A0B4KED9
uniprot id: O16844
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
messages: Homodimer (Potential). Binds microtubules. Interacts with ci, smo, sgg, CkIalpha and protein kinase A catalytic subunit (PubMed:15691767, PubMed:9244298). Interacts (via kinesin motor domain) with Ubr3 (PubMed:27195754).
messages: Polyubiquitinated by Ubr3, which leads to proteasomal degradation.
messages: Present at high levels during the first 4 hours of embryogenesis and at moderate levels between 4-12 hours.
messages: RNAi-mediated knockdown results in the increased expression of reactive oxygen species (ROS) in the gut of 7 day old conventionally reared adult flies. No increased ROS expression in germ-free adults and in response to bacteria-derived uracil.
messages: Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation (PubMed:25639794, PubMed:27195754). May negatively regulate a hh-signaling pathway which functions in the intestinal immune response to bacterial uracil by activating the Duox-dependent production of reactive oxygen species (ROS) (PubMed:25639794).
messages: cytoskeleton

7227:Dmel CG15143
gene id: 7227:Dmel_CG15143
uniprot id: Q9VJC5
names: Similarity
messages: Belongs to the CFAP91 family.

7227:Dmel CG12176
gene id: 7227:Dmel_CG12176
uniprot id: Q9VYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

7227:Dmel CG1768
gene id: 7227:Dmel_CG1768
uniprot id: M9NCZ5
uniprot id: M9PDV1
uniprot id: P48608
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formin homology family. Diaphanous subfamily.
messages: Cleavage furrow
messages: Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.
messages: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
messages: cytoskeleton

7227:Dmel CG32464
gene id: 7227:Dmel_CG32464
uniprot id: A0A0B4K620
uniprot id: A0A0B4K6S8
uniprot id: A4V2F2
uniprot id: B7Z0T3
uniprot id: Q0KIB9
uniprot id: Q4ABH3
uniprot id: Q7KNC5
uniprot id: Q8IPN9
uniprot id: Q8MSQ5
uniprot id: Q9VNA1
uniprot id: Q9VNA2
names: Similarity
messages: Belongs to the OXR1 family.

7227:Dmel CG5649
gene id: 7227:Dmel_CG5649
uniprot id: Q9VPH4
names: Similarity
messages: Belongs to the KIN17 family.

7227:Dmel CG4447
gene id: 7227:Dmel_CG4447
uniprot id: Q9VSW4
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

7227:Dmel CG4035
gene id: 7227:Dmel_CG4035
uniprot id: M9PBZ9
uniprot id: P48598
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Expressed at the posterior end of developing oocytes (at protein level) (PubMed:20869429). Preferential expression in the pole cells, at different developmental stages (PubMed:9065696).
messages: High levels of expression in early embryos, with levels decreasing slightly over the first 5 hours of embryogenesis (at protein level) (PubMed:28875934). Throughout development (PubMed:7742371, PubMed:9065696).
messages: Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934).
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1 (PubMed:25702871). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G (PubMed:14691132, PubMed:14723848, PubMed:14685270, PubMed:26294658, PubMed:22832024). The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14691132, PubMed:14723848, PubMed:14685270, PubMed:26294658, PubMed:22832024). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:11389445, PubMed:14645523, PubMed:26294658, PubMed:25702871). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).

7227:Dmel CG4207
gene id: 7227:Dmel_CG4207
uniprot id: Q8WTC1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Essential for gut mitochondrial activity. Might be involved in tissue specific growth factor production.
messages: Expressed both maternally and zygotically throughout development, lowest levels are in third larval instar and pupae.
messages: Expressed in anterior and posterior midgut primordia in stage 11 embryos. In stage 13 embryos, expression is high in the developing midgut and hindgut. In stage 16 embryos, expression is elevated in the midgut, hindgut, and in a small region that will give rise to pharyngeal muscles and to the stomatogastric nervous system. In larvae, expression is predominant in the gut, and head, presumably in pharyngeal muscles.
messages: Mitochondrion
messages: Mutants exhibit a strong systemic growth defect and die before reaching wild-type size.

7227:Dmel CG40293
gene id: 7227:Dmel_CG40293
uniprot id: P83098
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

7227:Dmel CG5706
gene id: 7227:Dmel_CG5706
uniprot id: Q9VCA5
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Lethal.
messages: Tetramer of two alpha and two beta subunits.

7227:Dmel CG7257
gene id: 7227:Dmel_CG7257
uniprot id: Q9VTQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG33717
gene id: 7227:Dmel_CG33717
uniprot id: B7Z0C3
uniprot id: Q9GN97
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Cell membrane
messages: Expressed in uninduced hemocytes and mbn-2 cells.
messages: Highly expressed in 0-5 hours embryos and in adult females, suggesting that it is expressed maternally.
messages: Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.

7227:Dmel CG9556
gene id: 7227:Dmel_CG9556
uniprot id: M9PFB5
uniprot id: Q94899
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CSN2 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
messages: Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8. Interacts with Rpn6.
messages: Cytoplasm
messages: Expressed both maternally with high levels during oogenesis, and zygotically.
messages: Expressed during embryonic stages 11-14 in the muscle attachment sites (apodemes); pharynx attachment to the roof of the mouth and in the epidermis of the head for the dorsal and ventral prothoracic pharyngeal muscle attachment. From stage 16 onwards expression is seen in all thoracic and abdominal apodemes.
messages: Nucleus

7227:Dmel CG40049
gene id: 7227:Dmel_CG40049
uniprot id: Q8SYP9
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

7227:Dmel CG8676
gene id: 7227:Dmel_CG8676
uniprot id: Q05192
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Expressed at all stages.
messages: Expressed throughout the blastodermal layer in early embryos. At later stages, strong expression is observed in the brain, ventral cord and hindgut.
messages: Monomer; forms a complex with ftz.
messages: Nucleus

7227:Dmel CG30092
gene id: 7227:Dmel_CG30092
uniprot id: A0A0B4KEX6
uniprot id: A0A0B4KFF9
uniprot id: E1JGS7
uniprot id: Q8MME5
uniprot id: Q9W204
uniprot id: Q9W205
names: Similarity
messages: Belongs to the filamin family.

7227:Dmel CG11942
gene id: 7227:Dmel_CG11942
uniprot id: Q9VWC3
names: Similarity
messages: Belongs to the SKP1 family.

7227:Dmel CG3058
gene id: 7227:Dmel_CG3058
uniprot id: Q8SZ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

7227:Dmel CG7430
gene id: 7227:Dmel_CG7430
uniprot id: Q9VVL7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

7227:Dmel CG3769
gene id: 7227:Dmel_CG3769
uniprot id: Q9VLB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

7227:Dmel CG9181
gene id: 7227:Dmel_CG9181
uniprot id: Q9W0G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Expressed during oogenesis and embryogenesis. Isoform A and isoform B are expressed in distinct patterns. Isoform B is expressed in the mesoderm and neuroblast layer during germband extension and later in the gut epithelia. Isoform A accumulates in 16 segmentally repeated stripes in the ectoderm during germband extension. These stripes are flanked by, and adjacent to, the domains of engrailed and wingless gene expression in the anterior/posterior axis. In stage 10 embryos, isoform A colocalizes with the area lateral to the denticle belts that will give rise to naked cuticle. Isoform A is also expressed later in embryogenesis in the central nervous system.
messages: Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state.
messages: Nucleus

7227:Dmel CG12196
gene id: 7227:Dmel_CG12196
uniprot id: Q32KD2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Chromosome
messages: Expressed in ovary (at protein level).
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis.
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus
messages: Oogenesis arrests at early stages. This arrest is accompanied by reduced proliferation of somatic cells required for egg chamber formation, and by apoptosis in both germ and somatic cell populations.
messages: Present most strongly at early stages of oogenesis, in germ cells in the germarium. Present in germ stem cells and dividing germline cyst cells. Weakly or not expressed in somatic cells at the tip of the germarium, including the terminal filament, inner sheath cells, or cap cells, but it is present at low levels in somatic cells in regions 2 and 3 of the germarium, including the prefollicular cells and the follicle cells of stage 1 egg chambers. Soon after egg chambers budd off the germarium, levels increase in the follicle cells. By mid-oogenesis it decreases in the nurse cells, while levels continued to increase in the follicle cells (at protein level).

7227:Dmel CG12386
gene id: 7227:Dmel_CG12386
uniprot id: P42279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG4448
gene id: 7227:Dmel_CG4448
uniprot id: Q9VCN9
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

7227:Dmel CG18081
gene id: 7227:Dmel_CG18081
uniprot id: Q9VUU7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG1662
gene id: 7227:Dmel_CG1662
uniprot id: Q9VYD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG5930
gene id: 7227:Dmel_CG5930
uniprot id: F0JAF9
uniprot id: P52654
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 1 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). TFIIA is a heterodimer of a unprocessed large subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p30), a beta (p20) and a gamma subunit (p14). Interacts with Tbp. Taf4 interacts with TFIIA-L when TFIIA-L is in complex with Tbp.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
messages: The precursor form (48 kDa) is cleaved to give rise to the alpha (30 kDa) and beta (20 kDa) subunits.

7227:Dmel CG34438
gene id: 7227:Dmel_CG34438
uniprot id: A1Z987
uniprot id: B3DN53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

7227:Dmel CG18076
gene id: 7227:Dmel_CG18076
uniprot id: A0A0B4K718
uniprot id: A0A0B4K788
uniprot id: A0A0B4K7P8
uniprot id: A0A0B4K7Y9
uniprot id: A0A0B4K867
uniprot id: A0A0B4K869
uniprot id: A1Z9I8
uniprot id: A1Z9I9
uniprot id: A1Z9J0
uniprot id: A1Z9J1
uniprot id: A1Z9J2
uniprot id: A1Z9J3
uniprot id: B7YZG2
uniprot id: B7YZG3
uniprot id: B7YZG4
uniprot id: B7YZG5
uniprot id: B7YZG6
uniprot id: E1JH62
uniprot id: E1JH63
uniprot id: E1JH64
uniprot id: E1JH65
names: Subcellular Location Annotation
messages: cytoskeleton

7227:Dmel CG3871
gene id: 7227:Dmel_CG3871
uniprot id: Q9Y1P6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG2151
gene id: 7227:Dmel_CG2151
uniprot id: P91938
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Can partially substitute for the cytoplasmic enzyme activity.
messages: Chimeric cDNA. Chimeric cDNA originating from chromosomes X and 3.
messages: Cytoplasm
messages: During embryogenesis, expression is seen in germ cell progenitors, developing midgut, hindgut and proventriculus.
messages: Expressed both maternally and zygotically during all stages of development, highest expression during adult stages.
messages: Homodimer.
messages: Mitochondrion
messages: Produced by alternative initiation at Met-106 of isoform B.
messages: The active site is a redox-active disulfide bond.
messages: Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.
messages: Unable to compensate for the loss of the mitochondrial enzyme activity.
messages: Was originally thought to be a glutathione reductase.

7227:Dmel CG1742
gene id: 7227:Dmel_CG1742
uniprot id: Q8SY19
uniprot id: Q8SY70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

7227:Dmel CG15255
gene id: 7227:Dmel_CG15255
uniprot id: Q9V445
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8577
gene id: 7227:Dmel_CG8577
uniprot id: C0HK98
uniprot id: C0HK99
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Constitutively expressed at high level in gut, in addition to the induced expression in fat body.
messages: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN) (PubMed:11106397, PubMed:12496260). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments (PubMed:12496260). Has no direct bacteriolytic activity (PubMed:12496260).
messages: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
messages: Secreted
messages: Up-regulated by PGN from B.subtilis.

7227:Dmel CG5490
gene id: 7227:Dmel_CG5490
uniprot id: A0A0B4KHY4
uniprot id: P08953
uniprot id: T2GGK5
names: Caution
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Toll-like receptor family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed both maternally and zygotically (PubMed:2449285, PubMed:1879347, PubMed:12617819). Maternal Tl increases in syncytial embryos, reaching a peak at the syncytial blastoderm stage and then decreases and is almost undetectable by the time of ventral furrow formation at gastrulation (at protein level) (PubMed:1879347). Expressed throughout development, with highest levels of expression in the embryo (PubMed:10973475). Expressed in all embryonic central nervous system axons (PubMed:19018662). In larvae, detected in the blood cells and fat body (PubMed:12617819).
messages: In early embryos, concentrated in the pseudocleavage furrows that form transiently between nuclei before cellularization and in the cleavage furrows during cellularization (at protein level) (PubMed:1879347). Later, found on cells in the mesectoderm, stomodeum, proctodeum, anterior and posterior midguts, splanchnopleura, salivary gland placode and adjacent to the segmentally repeated tracheal placodes (at protein level) (PubMed:1879347). During and after germ band shortening, localized in a number of cell types, including the salivary gland, foregut, hindgut, Malpighian tubules and epidermis (at protein level) (PubMed:1879347). In embryos, high expression in M13 with comparatively low expression in M12 (PubMed:20504957).
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: In the absence of ligand, forms a low-affinity disulfide-linked homodimer (PubMed:24733933). In the presence of ligand, crystal structures show one Tl molecule bound to a spaetzle C-106 homodimer (PubMed:24282309, PubMed:24733933). However, the active complex probably consists of two Tl molecules bound to a spaetzle C-106 homodimer (PubMed:24282309, PubMed:24733933). This is supported by in vitro experiments which also show binding of the spaetzle C-106 dimer to 2 Tl receptors (PubMed:12872120). Ligand binding induces conformational changes in the extracellular domain of Tl (PubMed:24282309). This may enable a secondary homodimerization interface at the C-terminus of the Tl extracellular domain (PubMed:24282309).
messages: Receptor for the cleaved activated form of spz, spaetzle C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:12872120, PubMed:8808632, PubMed:10973475). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:3931919). Promotes heterophilic cellular adhesion (PubMed:2124970). Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by tey (PubMed:20504957). May also function in embryonic neuronal survival and the synaptic targeting of SNa motoneurons (PubMed:19018662).
messages: Up-regulated during vesicular stomatitis virus (VSV) infection.

7227:Dmel CG8743
gene id: 7227:Dmel_CG8743
uniprot id: Q9VW35
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32849
gene id: 7227:Dmel_CG32849
uniprot id: Q9NFT7
names: Function
names: Similarity
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.

7227:Dmel CG33639
gene id: 7227:Dmel_CG33639
uniprot id: M9PHH4
uniprot id: Q9VWX4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG31509
gene id: 7227:Dmel_CG31509
uniprot id: A0A1B2AIV9
uniprot id: Q8IN44
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response.
messages: Belongs to the Turandot family.
messages: By stressful conditions such as bacterial infection, heat shock, mechanical pressure, dehydration, feeding with oxidative agents such as paraquat or exposure to ultraviolet light.
messages: Expressed in the fat body (at protein level).
messages: Expressed in the third larval instar and maintained through pupal development. Levels gradually increase during adulthood.
messages: Flies overexpressing TotA show prolonged survival and retain normal activity at otherwise lethal temperatures.
messages: Secreted

7227:Dmel CG10540
gene id: 7227:Dmel_CG10540
uniprot id: Q9W2N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.

7227:Dmel CG2161
gene id: 7227:Dmel_CG2161
uniprot id: A0A0B4LHS9
uniprot id: Q94547
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex composed of at least Pop2/Caf1-55, Ccr4, Not1, Rga/Not2, and Not3.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20504953, PubMed:23303381). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23303381). Essential for viability (PubMed:9475742). Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes (PubMed:9475742). Plays a role in germline stem cell differentiation in the ovaries (PubMed:29887366).
messages: Cytoplasm
messages: Expressed in embryos and adult (at protein level).
messages: Expressed in heterogeneous levels between adjacent germline stem cells (at protein level).

7227:Dmel CG8602
gene id: 7227:Dmel_CG8602
uniprot id: Q9VS47
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5807
gene id: 7227:Dmel_CG5807
uniprot id: A0A0B4KGZ8
uniprot id: Q9VC35
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: In the ovary, detected in germline stem cells and their progeny. Also detected in the somatic follicular epithelium.
messages: Larval lethal. Conditional knockdown in the ovary results in progressive loss of undifferentiated germline stem cells.
messages: Required during oogenesis to promote self-renewal of germline stem cells, probably by enhancing BMP signaling activity.

7227:Dmel CG1232
gene id: 7227:Dmel_CG1232
uniprot id: P48613
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality.
messages: Expressed weakly in middle to late embryos, absent in larvae and is most abundantly expressed in middle to late pupal stages.
messages: Membrane
messages: Preferentially expressed in the central nervous system of developing embryos, weaker expression is seen in the peripheral nervous system. In pupae and adults, expression is seen predominantly in heads, body and legs.

7227:Dmel CG8978
gene id: 7227:Dmel_CG8978
uniprot id: O97182
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

7227:Dmel CG14535
gene id: 7227:Dmel_CG14535
uniprot id: Q9VLW2
uniprot id: X2J924
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cytoskeleton

7227:Dmel CG10387
gene id: 7227:Dmel_CG10387
uniprot id: Q24558
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Maternally expressed. Accumulates in the developing oocyte.
messages: Nucleus
messages: Specifically expressed in the female germline.

7227:Dmel CG2822
gene id: 7227:Dmel_CG2822
uniprot id: B7Z009
uniprot id: M9PC22
uniprot id: M9PEE2
uniprot id: P17972
uniprot id: Q8SYL2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.
messages: Heterotetramer of potassium channel proteins.
messages: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: This channel protein belongs to the delayed rectifier class.

7227:Dmel CG9423
gene id: 7227:Dmel_CG9423
uniprot id: Q9V455
names: Similarity
messages: Belongs to the importin alpha family.

7227:Dmel CG3573
gene id: 7227:Dmel_CG3573
uniprot id: O46094
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

7227:Dmel CG2331
gene id: 7227:Dmel_CG2331
uniprot id: Q7KN62
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Homohexamer (PubMed:10564274). Interacts with tud, vas, papi and AGO3 (PubMed:18590813, PubMed:21447556). Interacts with Npl4 (PubMed:26471729).
messages: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation.
messages: Nucleus
messages: Present in egg, pupa and imago but not larva (at protein level).
messages: Present in the mushroom bodies of the protocerebrum and in the glomeruli of the antennal lobe. Present in nurse cells, oocytes and sperm bundles (at protein level).

7227:Dmel CG30059
gene id: 7227:Dmel_CG30059
uniprot id: Q95R73
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG43741
gene id: 7227:Dmel_CG43741
uniprot id: Q9I7F7
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Likely to act as a downstream effector of Cdc42 during dorsal closure, acting in a kinase independent manner with the other ACK family member Ack to positively regulate expression of the myosin zip by promoting the endocytosis of Egfr in the amnioserosa (AS).
messages: RNAi-mediated knockdown results in a low frequency of dorsal defects in the developing embryo (PubMed:18816840). RNAi-mediated knockdown does not rescue the small eye phenotypes induced by hid and rpr overexpression (PubMed:22615583). Simultaneous knockdown of Ack and Ack-like results in many embryos failing to properly secrete the cuticle likely due to the loss of zip expression (PubMed:18816840). Mutants also display defects in the dorsal surface including holes in the cuticle and germband retraction failure (PubMed:18816840).

7227:Dmel CG46121
gene id: 7227:Dmel_CG46121
uniprot id: A0A0U1QT59
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMC family.
messages: Cell membrane
messages: Expressed in multi-dendritic neurons of the labellum (md-L), which extend elaborate dendritic arbors innervating the bases of taste hairs (at protein level) (PubMed:27478019). In larvae, expressed in class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons (at protein level) (PubMed:27298354). In adults, expressed in various sensory neurons including those in the mouth parts, olfactory neurons in the antenna, wing bristle neurons, haltere neurons, arista neurons, and many other sensory neurons, including a subset of chordotonal (Cho) neurons (PubMed:27478019, PubMed:27298354). Expressed in md-L axon terminals, including those that project into the subesophageal zone (SEZ) (PubMed:27478019, PubMed:31184585). Also expressed in a small number of local neurons in the adult ventral nerve cord (VNC), and projections extending from a few neurons in the legs or wing hinges (PubMed:27478019). In the adult mouth, expressed in a few multi-dendritic neurons of the ventral cibarial sensory organ (VCSO); the multiple elaborate dendritic branches form a brush-like structure that faces the luminal side of the food-passing tunnel (PubMed:27478019). Also expressed in the oviduct and uterus of adult females (PubMed:32649914).
messages: Probable ion channel (PubMed:27478019, PubMed:30853433, PubMed:31184585, PubMed:32649914). Component of mechanosensitive neurons that participates in proprioception, sensing food texture, and directing egg-laying site selection (oviposition) (PubMed:27478019, PubMed:27298354, PubMed:30853433, PubMed:31184585, PubMed:32649914). Component of multi-dendritic neurons of the labellum (md-L) where it is required for sensing the hardness and viscosity of their food, enabling them to behaviorally discriminate their preferred softness and smoothness from harder and stickier food options (PubMed:27478019). Required as part of oviposition site selection process to relay mechanosensory and chemosensory information on the hardness and sweetness of potential egg-laying substrates, thus ensuring females select the most optimal site for their eggs survival (PubMed:31184585, PubMed:32649914). Females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:31184585, PubMed:32649914). This protein is required to sense subtle differences in substrate stiffness (between 0.25% and 0.3% agarose), likely acting in the md-L neurons (PubMed:32649914). Also required in neurons on the labellum, including the md-Ls, and possibly in the brain, to inhibit discrimination of egg-laying substrates of different hardness if the substrate contains sucrose (PubMed:32649914). During oviposition evaluation, activation of sweet neurons by sucrose enhances the activity of the Tmc neurons resulting in females losing their softness preference in favor of egg-laying sites that contain sucrose (PubMed:32649914). Acts in the larvae peripheral sensory neurons, to contribute to proprioception and sensory feedback for normal forward crawling behavior (PubMed:27298354, PubMed:30853433). R…
messages: Viable and appear morphologically normal (PubMed:27478019). Adults display a significant reduction in the electrophysiological responses of multi-dendritic neurons of the labellum (md-L) to mechanical stimuli (PubMed:27478019). Adults are unable to discriminate between the preferred softness (1% agarose) or smoothness (sucrose solution only) from harder or stickier food options (PubMed:27478019). Adult females display a reduced ability to discriminate between small differences in egg-laying substrate stiffness (PubMed:32649914). Larvae display abnormal locomotion behaviors that likely result from the loss of proprioceptive feedback (PubMed:27298354, PubMed:30853433). Displays reduced sensitivity to movement direction due to decreased activity of the dorsal proprioceptors neurons ddaD, which are activated during backward movement, and ddaE neurons which are activated during forward movement (PubMed:30853433). As a consequence, larvae crawling speed is reduced due to increased head curl behavior and increased backward locomotion (PubMed:27298354). No obvious defects in larvae dendrite morphology of class I da neurons or axon targeting of neurons in the ventral nerve cord (PubMed:27298354). Adults display a normal avoidance of bitter tastes such as quinine, denatonium, strychnine and berberine, and L4 and S6 sensilla display normal electrophysiological responses to salt, sucrose and caffeine (PubMed:27478019).
messages: dendrite

7227:Dmel CG1478
gene id: 7227:Dmel_CG1478
uniprot id: P07182
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chorion protein S36 family.
messages: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
messages: Secreted

7227:Dmel CG8383
gene id: 7227:Dmel_CG8383
uniprot id: A8JQW3
uniprot id: Q9VH84
names: Similarity
messages: Belongs to the pinin family.

7227:Dmel CG13822
gene id: 7227:Dmel_CG13822
uniprot id: Q9VCK2
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Involved in the immune response to bacterial infection.
messages: Lacks the conserved active site CXXC motif that is essential for thiol reductase activity. Its enzyme activity is therefore unsure.
messages: Secreted
messages: Up-regulated following injection with the Gram-negative bacterium E.coli. Up-regulation increases between 1 and 12 hours after the injection, then decreases between 12 and 48 hours, and then increases again at 72 hours.

7227:Dmel CG33876
gene id: 7227:Dmel_CG33876
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG17975
gene id: 7227:Dmel_CG17975
uniprot id: Q9U622
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7227:Dmel CG33898
gene id: 7227:Dmel_CG33898
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG9317
gene id: 7227:Dmel_CG9317
uniprot id: Q9VIK2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Carcinine transporter which is required for recycling of the neurotransmitter histamine in photoreceptor neurons of the compound eye. Following histamine release from photoreceptors and its uptake by glia where it is converted to carcinine, required for the uptake of carcinine from glia into photoreceptor cells where it can be hydrolyzed by tan to form histamine and beta-alanine.
messages: Cell membrane
messages: Defective photoreceptor synaptic transmission, significantly reduced phototaxis and decreased levels of histamine in photoreceptor terminals.
messages: Expressed in photoreceptor cells.
messages: axon

7227:Dmel CG13240
gene id: 7227:Dmel_CG13240
uniprot id: Q9V3W2
names: Similarity
messages: Belongs to the complex I NDUFB6 subunit family.

7227:Dmel CG12398
gene id: 7227:Dmel_CG12398
uniprot id: Q9VY02
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

7227:Dmel CG5850
gene id: 7227:Dmel_CG5850
uniprot id: M9NCT0
uniprot id: M9NEX9
uniprot id: M9PD30
uniprot id: Q0E8R8
uniprot id: Q9VL56
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4900
gene id: 7227:Dmel_CG4900
uniprot id: Q9VCV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

7227:Dmel CG10822
gene id: 7227:Dmel_CG10822
uniprot id: Q4QPW2
names: Similarity
messages: Belongs to the GAMAD family.

7227:Dmel CG3422
gene id: 7227:Dmel_CG3422
uniprot id: P22769
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31; this interaction is reduced by PI31 ADP-ribosylation.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG18405
gene id: 7227:Dmel_CG18405
uniprot id: M9MRI2
uniprot id: M9PB77
uniprot id: M9PCL7
uniprot id: M9PFA5
uniprot id: Q0E8S4
uniprot id: Q24322
names: Caution
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Expressed by subsets of neurons and muscles.
messages: Expression begins around stage 10, primarily in the developing CNS. In stage 16 embryos, it is expressed at highest levels throughout the CNS, and weak expression is seen in portions of the peripheral nervous system, most clearly in the lateral sensory clusters.
messages: Intron retention.
messages: Involved in growth cone guidance through its role in axonal repulsion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG8118
gene id: 7227:Dmel_CG8118
uniprot id: A0A0B4LGE6
uniprot id: P21519
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Chromosome
messages: During early neurogenesis, expression is ubiquitous. During later stages, expression concentrates at the central nervous system.
messages: May have a regulatory function possibly in association with the Notch gene product.
messages: Nucleus
messages: The protein has many AA homomeric domains: 21 poly-Gln runs (from 5 to 16 AA in length), 4 poly-Gly (6 to 10 AA), 3 poly-Asn (3 X 5 AA), 1 poly-Ala (10 AA) and 1 poly-Thr (5 AA) runs.

7227:Dmel CG2680
gene id: 7227:Dmel_CG2680
uniprot id: Q9W4W5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG31617
gene id: 7227:Dmel_CG31617
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG10206
gene id: 7227:Dmel_CG10206
uniprot id: Q9VM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

7227:Dmel CG5395
gene id: 7227:Dmel_CG5395
uniprot id: Q9VL02
uniprot id: X2J7P4
names: Similarity
messages: Belongs to the AAA ATPase family.

7227:Dmel CG15914
gene id: 7227:Dmel_CG15914
uniprot id: Q9VXN0
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

7227:Dmel CG10585
gene id: 7227:Dmel_CG10585
uniprot id: Q9VP87
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

7227:Dmel CG5163
gene id: 7227:Dmel_CG5163
uniprot id: A0A1B2AK92
uniprot id: P52656
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TFIIA subunit 2 family.
messages: Females are sterile.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation (PubMed:7958898). TFIIA in a complex with TBP mediates transcriptional activity (PubMed:7958898). Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004). Forms a complex with Moonshiner/CG12721 and Trf2 which recruit transcriptional machinery to heterochromatin to initiate the bidirectional transcription of piRNA clusters, by interacting with the RDC (rhi, del and cuff) complex that binds to repressive H3K9me3 marks in the chromatin (PubMed:28847004). This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004).
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (PubMed:7958898). It was originally believed to be a heterotrimer of an alpha (p30), a beta (p20) and a gamma (p14) subunit (PubMed:7958898). Forms a complex with Moonshiner/CG12721 and Trf2 (PubMed:28847004).
messages: Ubiquitous.

7227:Dmel CG9399
gene id: 7227:Dmel_CG9399
uniprot id: A0A0B4KFZ7
uniprot id: Q9VHB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG4394
gene id: 7227:Dmel_CG4394
uniprot id: Q8IR14
uniprot id: Q960H6
names: Subcellular Location Annotation
messages: Cytoplasm

7227:Dmel CG8050
gene id: 7227:Dmel_CG8050
uniprot id: P23779
names: Similarity
messages: Belongs to the cystatin family.

7227:Dmel CG17347
gene id: 7227:Dmel_CG17347
uniprot id: Q9VIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

7227:Dmel CG16928
gene id: 7227:Dmel_CG16928
uniprot id: Q9XYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

7227:Dmel CG10067
gene id: 7227:Dmel_CG10067
uniprot id: C8VV69
uniprot id: P53501
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In Drosophila there are 6 closely related actin genes.
messages: Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
messages: Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
messages: cytoskeleton

7227:Dmel CG4590
gene id: 7227:Dmel_CG4590
uniprot id: E1JJF3
uniprot id: Q9V427
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Apicolateral cell membrane
messages: Basolateral cell membrane
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed maternally and zygotically. Expressed during oogenesis and embryogenesis. Expressed in larvae and pupae.
messages: Expression in embryos at ectoderm/endoderm boundaries during gut organogenesis is induced by activation of the wg signaling cascade.
messages: Female sterility. Only one third of the zygotic mutant embryos survive up to the first instar larval stage. These mutant larvae display a feeding defect most probably caused by a keyhole formation defect during proventriculus development. The feeding defect may result in larvae death by starvation. Zygotic mutant embryos display large holes in the head region and a variable spectrum of segment defects. In maternal and zygotic mutant embryos, epithelial tissues and organs are severely affected, the cuticle fails to form and extensive cell death occurs.
messages: In ovary, expressed in inner germarial sheath cells, prefollicular cells, follicle cells, nurse cells and oocytes. Expressed in embryonic epithelial cells. Expressed in foregut and hindgut from stage 11-17, segmentally repeated tracheal placodes at stage 14, salivary gland at stage 16 and proventriculus at stage 16-17 (at protein level). During germband extension stage (stage 7), expressed in epidermal epithelial cells. Expressed in cephalic furrow. Repeating epidermal pattern emerges at stage 11, refines to one or two cells at each side of the segment borders by stage 13. Expressed in the imaginal wing disk. In pupae, expressed in the CNS and in primary, secondary and tertiary pigment cells of the retina. Expressed in optic lamina of the adult CNS.
messages: Lateral cell membrane
messages: Membrane
messages: Monomer and heterooligomer with ogre or Inx3 (via cytoplasmic C-terminal region). Interacts (via cytoplasmic loop) with shg (via cytoplasmic region). Interacts with arm.
messages: Structural component of the gap junctions.
messages: Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst formation.
messages: gap junction

7227:Dmel CG10181
gene id: 7227:Dmel_CG10181
uniprot id: Q00748
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Membrane

7227:Dmel CG17660
gene id: 7227:Dmel_CG17660
uniprot id: Q9VQ34
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6588
gene id: 7227:Dmel_CG6588
uniprot id: P10674
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed on different subsets of axon bundles (fascicles) in insect embryos.
messages: Neural cell adhesion molecule.

7227:Dmel CG12286
gene id: 7227:Dmel_CG12286
uniprot id: C8VV48
uniprot id: Q9VG39
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4752
gene id: 7227:Dmel_CG4752
uniprot id: Q9W247
names: Similarity
messages: Belongs to the oxoprolinase family.

7227:Dmel CG16941
gene id: 7227:Dmel_CG16941
uniprot id: Q9VEP9
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG10013
gene id: 7227:Dmel_CG10013
uniprot id: Q9VGA7
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

7227:Dmel CG16960
gene id: 7227:Dmel_CG16960
uniprot id: P81914
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in 1-2 cells on the distal edge of the antenna but not the maxillary palp.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG6932
gene id: 7227:Dmel_CG6932
uniprot id: Q9VCY3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center. Its function as protease is therefore unsure.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
messages: Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG8805
gene id: 7227:Dmel_CG8805
uniprot id: A0A0B4LEJ6
uniprot id: Q7KGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7227:Dmel CG6821
gene id: 7227:Dmel_CG6821
uniprot id: P11997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hemocyanin family.
messages: Heterohexamer, composed of three subunits, alpha, beta and gamma.
messages: Larval hemolymph.
messages: Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
messages: extracellular space

7227:Dmel CG4408
gene id: 7227:Dmel_CG4408
uniprot id: Q7JVX3
uniprot id: Q9VCM8
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG1702
gene id: 7227:Dmel_CG1702
uniprot id: E1JJS1
uniprot id: Q9VRA4
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

7227:Dmel CG7260
gene id: 7227:Dmel_CG7260
uniprot id: M9PEX3
uniprot id: P55965
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: First expressed at the beginning of nuclear cycle 14 in the posterior terminal region. As cellularization proceeds, expression becomes confined to a ring area encompassing the primordium of the hindgut and anal pads. Expression is maintained in this region until the end of embryogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for the specification of the hindgut and anal pads.

7227:Dmel CG15107
gene id: 7227:Dmel_CG15107
uniprot id: A0A0B4KFV4
uniprot id: Q7JW01
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG4573
gene id: 7227:Dmel_CG4573
uniprot id: Q9VV59
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

7227:Dmel CG1643
gene id: 7227:Dmel_CG1643
uniprot id: Q9W3R7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG5 family.
messages: Conjugated to Atg12, which is essential for autophagy.
messages: Cytoplasm
messages: Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).
messages: Preautophagosomal structure membrane

7227:Dmel CG9995
gene id: 7227:Dmel_CG9995
uniprot id: Q9V3N4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG1883
gene id: 7227:Dmel_CG1883
uniprot id: Q8IMI7
uniprot id: Q9VA91
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

7227:Dmel CG9350
gene id: 7227:Dmel_CG9350
uniprot id: Q7JYH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7227:Dmel CG5974
gene id: 7227:Dmel_CG5974
uniprot id: Q05652
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed both maternally and zygotically with low levels of expression throughout the life cycle.
messages: Interacts (via Death domain) with tub (via Death domain). Interacts with Pellino (Pli).
messages: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.

7227:Dmel CG5278
gene id: 7227:Dmel_CG5278
uniprot id: Q9VCY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7227:Dmel CG11655
gene id: 7227:Dmel_CG11655
uniprot id: Q9VXV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

7227:Dmel CG2200
gene id: 7227:Dmel_CG2200
uniprot id: Q9VYH3
uniprot id: X2JER0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S51 family.
messages: Cytoplasm
messages: Hydrolyzes dipeptides containing N-terminal aspartate residues.

7227:Dmel CG10002
gene id: 7227:Dmel_CG10002
uniprot id: A0A0B4KHC0
uniprot id: A0A126GV17
uniprot id: E1JJ07
uniprot id: P14734
names: Function
names: Subcellular Location Annotation
messages: Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.
messages: Nucleus

7227:Dmel CG17637
gene id: 7227:Dmel_CG17637
uniprot id: Q9VPD9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6253
gene id: 7227:Dmel_CG6253
uniprot id: A0A1B2AIV7
uniprot id: P55841
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

7227:Dmel CG7395
gene id: 7227:Dmel_CG7395
uniprot id: Q9VW75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7227:Dmel CG5052
gene id: 7227:Dmel_CG5052
uniprot id: Q24454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG32707
gene id: 7227:Dmel_CG32707
uniprot id: E1JJG4
uniprot id: Q9W395
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

7227:Dmel CG4182
gene id: 7227:Dmel_CG4182
uniprot id: Q9VJQ3
names: Similarity
messages: Belongs to the major royal jelly protein family.

7227:Dmel CG1072
gene id: 7227:Dmel_CG1072
uniprot id: M9PE75
uniprot id: M9PEI5
uniprot id: Q8IRC7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all stages of zygotic development, with highest levels of expression during embryonic and early pupal stages, and lower levels in larval and adult stages.
messages: First detected in neuroblasts in stage 9 embryos. Expressed in all 10 abdominal segments and in the labial segment during early embryogenesis. Expressed in the stage 14 developing epithelium. By embryonic stage 16, expression is refined to the abdominal histoblasts and salivary gland imaginal ring cells. Expressed in both larval and imaginal cells between the salivary gland and the salivary gland imaginal ring, in late third instar larvae. Also expressed in specific areas of the larval wing, leg and eye-antennal disks.
messages: Nucleus
messages: Probable transcription factor. Required for the establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings.

7227:Dmel CG18304
gene id: 7227:Dmel_CG18304
uniprot id: M9NCS3
uniprot id: M9PCS5
names: Similarity
messages: Belongs to the SOGA family.

7227:Dmel CG10153
gene id: 7227:Dmel_CG10153
uniprot id: Q7K2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

7227:Dmel CG6120
gene id: 7227:Dmel_CG6120
uniprot id: A0A0B4KH03
uniprot id: Q9V3X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG12845
gene id: 7227:Dmel_CG12845
uniprot id: Q7K010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7227:Dmel CG3661
gene id: 7227:Dmel_CG3661
uniprot id: P48159
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

7227:Dmel CG6159
gene id: 7227:Dmel_CG6159
uniprot id: Q9XTM1
uniprot id: S5MHR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.

7227:Dmel CG14307
gene id: 7227:Dmel_CG14307
uniprot id: Q8IN81
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in parts of the adult male brain associated with the courtship song and steps of the male courtship. Also expressed in the larval and pupal male mushroom body and optic lobe. Expressed in pupal female optic lobe.
messages: Mutant males exhibit bisexual behavior; they court females but are behaviorally sterile so fail to mate and they exhibit vigorous courtship with other fru mutant males.
messages: Nucleus
messages: Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body.

7227:Dmel CG31720
gene id: 7227:Dmel_CG31720
uniprot id: E2QCS3
uniprot id: Q8IPD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane
messages: Membrane

7227:Dmel CG5290
gene id: 7227:Dmel_CG5290
uniprot id: Q9VVM8
names: Similarity
messages: Belongs to the TTC27 family.

7227:Dmel CG1475
gene id: 7227:Dmel_CG1475
uniprot id: A0A0B4KFM7
uniprot id: Q9VNE9
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

7227:Dmel CG6367
gene id: 7227:Dmel_CG6367
uniprot id: Q9VWU1
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Increased susceptibility to fungal infection and failure to induce the expression of antifungal peptide Drs in response to fungal infection but not in response to E.coli or M.luteus bacterial infection.
messages: Secreted
messages: Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases (PubMed:12098703, PubMed:18724373, PubMed:16399077). Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz (PubMed:12098703, PubMed:18724373, PubMed:16399077). Nec regulates the cascade by inhibiting psh (PubMed:12098703).
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG7018
gene id: 7227:Dmel_CG7018
uniprot id: A0A0S0WIJ8
uniprot id: A0A0S0WNC2
uniprot id: A0A0U1RFE7
uniprot id: P29774
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Embryonic ventral nervous system, higher in the thoracic than abdominal segments.
messages: Expressed throughout development.
messages: Nucleus

7227:Dmel CG8804
gene id: 7227:Dmel_CG8804
uniprot id: A0A0B4K7K7
uniprot id: Q9V576
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Expressed in embryonic gut in a pattern that guides germ cells towards mesoderm (initially in hindgut and then on lower side of gut). During extended germ band stage, expressed in ectoderm as a medial band throughout the trunk.
messages: Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.
messages: Membrane
messages: Responsible for guiding the germ cells early in the process of migration from the lumen of the developing gut towards the overlying mesoderm, where the germ cells enter the gonads. May be involved in lipid metabolism.

7227:Dmel CG13089
gene id: 7227:Dmel_CG13089
uniprot id: Q9VLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG44153
gene id: 7227:Dmel_CG44153
uniprot id: Q9VL42
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG15920
gene id: 7227:Dmel_CG15920
uniprot id: Q9V7U0
names: Biotechnology
names: Developmental Stage
names: Function
messages: Expressed at pupal stage only.
messages: Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.
messages: Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.

7227:Dmel CG5539
gene id: 7227:Dmel_CG5539
uniprot id: Q9W1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

7227:Dmel CG9446
gene id: 7227:Dmel_CG9446
uniprot id: A0A0B4KEJ7
uniprot id: A0A0B4KEU5
uniprot id: Q7JVY0
names: Similarity
messages: Belongs to the WD repeat coronin family.

7227:Dmel CG3219
gene id: 7227:Dmel_CG3219
uniprot id: Q45EX0
uniprot id: Q9W1U4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
messages: Defects in chromosome segregation, but does not affect the mitotic spindle.
messages: Required during anaphase to drive sister chromatid separation to actively depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid mobility through a 'Pac-man' mechanism.
messages: centromere
messages: kinetochore
messages: spindle pole

7227:Dmel CG12321
gene id: 7227:Dmel_CG12321
uniprot id: Q9VEC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

7227:Dmel CG7908
gene id: 7227:Dmel_CG7908
uniprot id: Q9VAC5
names: Cofactor
names: Domain
names: Sequence Caution
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Membrane
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Wrong choice of frame.

7227:Dmel CG8370
gene id: 7227:Dmel_CG8370
uniprot id: A0A0B4LFJ4
uniprot id: Q9V7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM131 family.
messages: Membrane

7227:Dmel CG33801
gene id: 7227:Dmel_CG33801
uniprot id: Q4ABE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG11342
gene id: 7227:Dmel_CG11342
uniprot id: N0D4J1
uniprot id: Q9VZD2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Probable RNA methyltransferase.

7227:Dmel CG14394
gene id: 7227:Dmel_CG14394
uniprot id: A8JQY7
uniprot id: A8JQY8
uniprot id: B7Z0S7
uniprot id: B7Z0S8
uniprot id: E2QD33
uniprot id: Q4V5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

7227:Dmel CG8704
gene id: 7227:Dmel_CG8704
uniprot id: Q26263
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Homodimer (PubMed:22357926, PubMed:7651341). Heterodimer with E(spl)mgamma-HLH and E(spl) (PubMed:22357926). Transcription repression requires formation of a complex with the corepressor protein Groucho (PubMed:8001118). Interacts (via bHLH motif) with sisA (PubMed:7651341). Interacts with da (PubMed:7651341).
messages: In larvae, expressed in primary neural precursors (at protein level) (PubMed:1427077). In leg imaginal disks, expressed in stripes at the distal edge of each leg segment primordium (at protein level) (PubMed:1427077). In stage 9 embryo, detected in the first neuroblasts delaminating from the ectoderm (at protein level) (PubMed:22357926). In newly hatched larvae, detected in dividing neuroblasts (at protein level) (PubMed:22357926). First detected in preblastoderm cycle 12 in all nuclei (PubMed:1427077). During middle to late cycle 13, expressed in eight stripes that overlap those of the hairy protein (PubMed:1427077).
messages: Lethal at different developmental stages (PubMed:1427077). In late third instar larval brains, results in a complete absence of type II neuroblasts (NBs) and a reduction of type I NBs; after larval hatching, loss of neuroblasts in the ventral nerve cord and specific loss of type I neuroblasts within 48 hours; in the pupae, results in a premature loss of mushroom body NBs (PubMed:23056424, PubMed:21262215, PubMed:22357926). Escaper adult flies display weak motor activity, lethargic behavior, and shortened life span (PubMed:1427077). RNAi-mediated knockdown of the protein in type II neuroblasts lineage results in an increase in the number of type II neuroblasts (PubMed:28899667). Simultaneous RNAi-mediated knockdown of the ETS protein pnt or the transcriptional repressor Erm restores normal neuroblast numbers (PubMed:28899667).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
messages: Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:1427077, PubMed:28899667, PubMed:24618901). In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH (PubMed:28899667, PubMed:23056424, PubMed:21262215, PubMed:24618901, PubMed:22357926). As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch (PubMed:21262215, PubMed:22357926, PubMed:23056424). In the developing larval and pupal brain, required for mushroom body differentiation (PubMed:22357926). Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho (PubMed:8001118, PubMed:7651341).

7227:Dmel CG11703
gene id: 7227:Dmel_CG11703
uniprot id: Q9V3Q7
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

7227:Dmel CG3333
gene id: 7227:Dmel_CG3333
uniprot id: A0A0B4K8B2
uniprot id: E1JGV6
uniprot id: O44081
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Isoform C is expressed both maternally and zygotically. Isoform A is expressed at the same level in adult females but at a much lower level in ovaries.
messages: Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis.
messages: nucleolus

7227:Dmel CG6141
gene id: 7227:Dmel_CG6141
uniprot id: P50882
uniprot id: X2JDU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

7227:Dmel CG7659
gene id: 7227:Dmel_CG7659
uniprot id: O16867
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryos, expression continues to the final stages of neurogenesis.
messages: Expressed in neuronal and glial precursors during differentiation. In the peripheral nervous system, expression is exclusively in one of the neurons that innervate each larval chemosensory organ. Expressed at a late stage in the development of one type of adult chemosensory organ, the gustatory bristles of the leg, wing and proboscis. Expressed very early in the development of a second type of chemosensory receptors, the olfactory organs of the antenna.
messages: May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.
messages: Nucleus

7227:Dmel CG10251
gene id: 7227:Dmel_CG10251
uniprot id: Q9VCJ5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG1976
gene id: 7227:Dmel_CG1976
uniprot id: Q9V9S7
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

7227:Dmel CG9821
gene id: 7227:Dmel_CG9821
uniprot id: Q9VHK8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG1978
gene id: 7227:Dmel_CG1978
uniprot id: D5A7J8
uniprot id: Q9V568
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to hexanol, pentyl acetate, benzyl acetate, and 2-heptanone.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG3324
gene id: 7227:Dmel_CG3324
uniprot id: Q03042
names: Activity Regulation
names: Developmental Stage
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Binding of cGMP results in enzyme activation.
messages: Highest expression is in embryos, low level expression is seen through rest of development.
messages: Homodimer.
messages: In embryo stage 13, expression is seen in a few large, irregular cells having the appearance of hemocytes or macrophages. In adults, expression is seen in optic lamina and weakly in testis.
messages: cGMP-dependent protein kinase 1 consists of 3 types of domains: the regulatory domain, two cGMP-binding regions and the catalytic domain.

7227:Dmel CG1389
gene id: 7227:Dmel_CG1389
uniprot id: P18475
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Expressed both maternally and zygotically. Expressed throughout the embryo but is activated specifically at the poles (PubMed:2927509, PubMed:8423783, PubMed:19965758). Expressed in the prothoracic gland in wandering L3 larvae (PubMed:19965758).
messages: May be auto-phosphorylated on tyrosine residues.
messages: Membrane
messages: Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo (PubMed:2927509, PubMed:8423783). During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth (PubMed:19965758). Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity).
messages: RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage. In addition, pupal size and, to a lesser extent, PG cell size are increased.

7227:Dmel CG8386
gene id: 7227:Dmel_CG8386
uniprot id: Q7K1Z5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage (By similarity). As part of Ufm1 cascade, might play a role in the development of the neuromuscular junctions (PubMed:26872069).
messages: Interacts with Uba5 (via C-terminus). Interacts with Ufl1.
messages: RNAi-mediated knockdown shows aberrant neuromuscular junctions in the larval muscle, and abnormal wings together with locomotive defects in the adult.

7227:Dmel CG11166
gene id: 7227:Dmel_CG11166
uniprot id: Q7JRJ1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF family.
messages: Component of the little elongation complex, at least composed of Ell, Eaf, Ice1 and Ice2.
messages: Loss of adult progeny and reduced male-female sex ratio.
messages: Nucleus
messages: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.

7227:Dmel CG42613
gene id: 7227:Dmel_CG42613
uniprot id: A0A0B4K686
uniprot id: A0A0B4K6C8
uniprot id: A0A0B4K760
uniprot id: Q9VE20
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG13190
gene id: 7227:Dmel_CG13190
uniprot id: Q9V629
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DXO/Dom3Z family.
messages: Chromosome
messages: Cytoplasm
messages: Females exhibit severely reduced fecundity. Defects in germline cyst development and result in ventralized eggs as a result of reduced Grk expression. Increase in the transcript levels of two retrotransposable elements, Het-A and Tart.
messages: In contrast to other members of the family that display ribonuclease activity, lacks the conserved catalytic sites that bind the divalent metal cations. Ribonuclease activity is therefore unsure.
messages: Interacts with rhi.
messages: Involved in the piRNA pathway in germline. tissues.

7227:Dmel CG7409
gene id: 7227:Dmel_CG7409
uniprot id: Q9VSA9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG16912
gene id: 7227:Dmel_CG16912
uniprot id: Q9W107
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Homodimer.
messages: Mitochondrion matrix

7227:Dmel CG3587
gene id: 7227:Dmel_CG3587
uniprot id: O46079
names: Similarity
messages: Belongs to the KTI12 family.

7227:Dmel CG3009
gene id: 7227:Dmel_CG3009
uniprot id: E1JJG5
uniprot id: Q9W4I0
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG8445
gene id: 7227:Dmel_CG8445
uniprot id: Q7K5N4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex, at least composed of calypso and Asx.
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Polycomb phenotype leading to lethality, probably due to misexpression of homeotic genes.

7227:Dmel CG17116
gene id: 7227:Dmel_CG17116
uniprot id: Q9VKR5
uniprot id: X2J9C9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG3838
gene id: 7227:Dmel_CG3838
uniprot id: Q9VLA6
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13478
gene id: 7227:Dmel_CG13478
uniprot id: M9PI59
uniprot id: Q9VUF8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Member of the Halloween gene group.
messages: Mitochondrion membrane
messages: Required for CNS development; midline glial cells. Involved in the metabolism of insect hormones; responsible for all ecdysone 20-monooxygenase activity during embryonic, larval and adult stages. May be involved in the breakdown of synthetic insecticides.
messages: Strong expression by embryonic stage 10 in epidermis, decreases significantly in older embryos. Third instar larvae show expression in the midgut copper cells, Malpighian tubules and fat body. In the adult ovaries, expression is seen in both nurse cells and centripetally migrating follicle cells.

7227:Dmel CG17348
gene id: 7227:Dmel_CG17348
uniprot id: Q27324
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: In the embryonic abdominal hemisegment, expression is restricted to cell body, axon and growth cone of a cluster of 20 ventral nerve cord interneurons. During muscle growth and attachment events in the embryonic abdominal hemisegment, expression is in somatic muscle fibers 21-23 at 10-13 hours and 2 patches of approximately 15 neighboring epidermal cells (dorsal and ventral attachment sites) at 6-13 hours.
messages: Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.
messages: The extracellular WIF domain is responsible for Wnt binding.

7227:Dmel CG5258
gene id: 7227:Dmel_CG5258
uniprot id: M9PCI2
uniprot id: Q9V3U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

7227:Dmel CG9120
gene id: 7227:Dmel_CG9120
uniprot id: A0A1B2AJT6
uniprot id: P37161
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Found in the midgut.
messages: Rises dramatically in the late third instar, then decreases gradually during the pupal stages. Low expression is found in adults.
messages: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis.

7227:Dmel CG10244
gene id: 7227:Dmel_CG10244
uniprot id: Q9VBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Membrane

7227:Dmel CG7861
gene id: 7227:Dmel_CG7861
uniprot id: A1Z6J5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm
messages: Embryonic lethal, with a few escapers that develop to first-instar larvae. In larval muscles the microtubule (MT) network is greatly reduced with a decrease in the number and length of MT fibers. RNAi-mediated knockdown in larval neurons and muscles results in a significant increase in roll-over time. RNAi-mediated knockdown in pre- and post-synaptic neurons results in increased branching number, increased bouton number and decreased bouton size at the neuromuscular junction (NMJ) synaptic terminals. Presynaptic knockdown also results in increased excitatory junction potentials (EJPs) and miniature excitatory junction potentials (mEJPs) of NMJ synapses, whereas knockdown in postsynaptic neurons has no effect on neurotransmission parameters.
messages: In embryos, expressed ubiquitously with higher expression levels in the central nervous system and muscles (at protein level). Expression levels decrease from the embryonic to larval stage (at protein level). In third-stage larva, high levels of expression in the epidermal cells with lower levels of expression in the muscles, central neurons and peripheral axons (at protein level).
messages: Tubulin-folding protein which is required for the development of the neuronal microtubule network. Essential for the development and function of neuromuscular synapses. Likely to promote microtubule formation by acting in the negative regulation of the microtubule-severing protein spas.

7227:Dmel CG4328
gene id: 7227:Dmel_CG4328
uniprot id: Q9VTW3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG3210
gene id: 7227:Dmel_CG3210
uniprot id: Q9VQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

7227:Dmel CG30342
gene id: 7227:Dmel_CG30342
uniprot id: Q7JVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome C complex (PubMed:18981222). Interacts with Mfap1 (via C-terminus) (PubMed:18765666).
messages: Detected in all germal and follicle cells.
messages: Nucleus
messages: Required for pre-mRNA splicing.

7227:Dmel CG3326
gene id: 7227:Dmel_CG3326
uniprot id: M9PC18
uniprot id: Q9VQN8
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Hexamer.

7227:Dmel CG4268
gene id: 7227:Dmel_CG4268
uniprot id: D3PFF6
uniprot id: Q9VPC0
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Expressed both maternally and zygotically. Highest levels in early embryogenesis (0-6 hours), low levels during later embryogenesis, moderate levels in pupae and adults.
messages: Intron retention.
messages: Nucleus
messages: Present throughout the early embryo. In late embryos levels are highest in the CNS.

7227:Dmel CG15077
gene id: 7227:Dmel_CG15077
uniprot id: Q9V8M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion membrane

7227:Dmel CG13402
gene id: 7227:Dmel_CG13402
uniprot id: Q9VY63
names: Similarity
messages: Belongs to the NAC-beta family.

7227:Dmel CG12796
gene id: 7227:Dmel_CG12796
uniprot id: Q9W3V5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG9391
gene id: 7227:Dmel_CG9391
uniprot id: Q7KTW5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7227:Dmel CG5072
gene id: 7227:Dmel_CG5072
uniprot id: Q7K306
names: Similarity
messages: Belongs to the protein kinase superfamily.

7227:Dmel CG11163
gene id: 7227:Dmel_CG11163
uniprot id: Q8T0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7227:Dmel CG8542
gene id: 7227:Dmel_CG8542
uniprot id: A0A0B4LFD2
uniprot id: P29845
names: Developmental Stage
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Heat shock cognate proteins are expressed constitutively during normal development.

7227:Dmel CG3108
gene id: 7227:Dmel_CG3108
uniprot id: Q9W475
names: Similarity
messages: Belongs to the peptidase M14 family.

7227:Dmel CG17678
gene id: 7227:Dmel_CG17678
uniprot id: P25157
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Cytoplasm
messages: Expressed throughout oogenesis. In early embryos, expression drops during cellularization, remains low throughout gastrulation and increases once germband extension has begun.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
messages: In ovary, expressed in nurse cells and oocyte. In early embryos, distributed uniformly. At the extended germband stage, accumulates in the mesoderm.
messages: May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes.

7227:Dmel CG7768
gene id: 7227:Dmel_CG7768
uniprot id: Q7K2I4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG9204
gene id: 7227:Dmel_CG9204
uniprot id: A0A0B4KFD5
uniprot id: O96539
names: Function
names: Sequence Caution
names: Similarity
messages: Belongs to the R-transferase family.
messages: Deletion of many residues.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

7227:Dmel CG7524
gene id: 7227:Dmel_CG7524
uniprot id: M9MSK3
uniprot id: P00528
uniprot id: X2JCI2
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Abundant in embryos and pupae, rare in larvae and adults.
messages: After the first 8 hours of development, accumulates almost exclusively in neural tissues such as the brain, ventral nerve chord, and eye-antennal disks, and in differentiating smooth muscle.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Interacts with hzg.
messages: May play a role in the development of neural tissue and smooth muscle.
messages: Phosphorylated.

7227:Dmel CG12908
gene id: 7227:Dmel_CG12908
uniprot id: A1Z877
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell adhesion glycoprotein which is widely distributed in basement membranes (PubMed:30260959, PubMed:30567930). Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks (PubMed:30260959, PubMed:30567930). Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity (PubMed:30567930). Not involved in assembly of the embryonic basement membrane (PubMed:30567930).
messages: Expressed in different patterns throughout embryogenesis (at protein levels) (PubMed:30260959, PubMed:30567930). At stage 11/12, embeds dorsal median cells and somatic myoblasts forming a thin layer between the ectoderm and the mesoderm and around the prospective anal plate (PubMed:30567930). At stage 12, after germ band retraction, accumulates in the forming basal membranes around the developing brain and ventral nerve cord, in the differentiating tracheal system, in the future digestive tract as well as in the forming somatic muscles (PubMed:30567930). At stage 13, accumulates around caudal visceral mesodermal cells (PubMed:30260959). At stage 16, expressed in the basal membrane surrounding most tissues, including muscles, gut and larval ventral nerve cord, brain, and in chordotonal organs (at protein level) (PubMed:30260959, PubMed:30567930). Expressed in embryonic macrophages (at protein level) (PubMed:30260959). In the larva, expressed mainly by fat body adipocytes and blood cells in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level) (PubMed:30260959). Expressed during embryogenesis: at stage 11/12 detected in single cells of the head, especially in the gnathal segments as well as in segmentally located patches of cells in the dorsal mesoderm, detected in the midline-associated, mesodermal dorsal median cells and somatic myoblasts (PubMed:30567930). Only low expression in the amnioserosa (PubMed:30567930). After germ band retraction (stage 12), expressed in the forming dorsal and ventral muscles, the amnioserosa and the segmentally located chordotonal organs (PubMed:30567930). Expressed in the esophageal visceral muscle primordium and in the joint region between hind- and midgut (PubMed:30567930). At stage 16, expressed in somatic and visceral muscles, and in the cap cells of the chordotonal organs (PubMed:30567930).
messages: Expressed in the basement membrane around the follicular epithelium of the adult ovary (at protein level).
messages: Reduces fertility (PubMed:30260959, PubMed:30567930). In larvae results in impaired climbing abilities and in multiple holes in the basal membrane surrounding the fat body adipose, the somatic muscles and the longitudinal and circular visceral muscles, affecting permeability and mechanical stability of the basement membrane (PubMed:30260959, PubMed:30567930). Impairs larvae movement including reduced crawling speed, smaller stride frequency and exploration area together with sudden motion defects in their crawling pattern, such as head shaking, and spontaneous rolling and bending (PubMed:30567930). Increases neuromuscular junction (NMJ) size including abnormal branching numbers, overall branch length and enhanced bouton density suggesting defective NMJ maturation (PubMed:30567930). Reduces reaction to vibrational stimuli with partial loss of alignment of sensory cilia and morphological defects of the larval peripheral nervous system (PubMed:30567930). Results in smaller pupae presenting an orientation shift of the pupal cases towards the horizontal axis (PubMed:30567930). Results in incompletely inflated wing blades in a small group of adults (PubMed:30567930).
messages: Secreted
messages: The EGF-like 1 and nidogen G2 beta-barrel domain (also known as globular region 2 or G2) contribute to the localization to the basal membrane probably by binding to vkg.
messages: The EGF-like 2-8 domains (also known as the ROD domain) is necessary but not sufficient for localization to the basal membrane.
messages: The LDL-receptor class B 1-4 domains (also known as globular region 3 or G3) is necessary for cell-extracellular matrix (ECM) interactions. Also, contributes to the localization to the basal membrane probably by binding to laminins.
messages: The NIDO domain (also known as globular region 1 or G1) contributes to the localization to the basal membrane probably by binding to vkg.
messages: basement membrane

7227:Dmel CG18208
gene id: 7227:Dmel_CG18208
uniprot id: A0A0B4KHD0
uniprot id: A0A0B4KHQ6
uniprot id: Q9VE32
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG1258
gene id: 7227:Dmel_CG1258
uniprot id: Q9VZF5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7227:Dmel CG4971
gene id: 7227:Dmel_CG4971
uniprot id: Q9VM25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7227:Dmel CG10118
gene id: 7227:Dmel_CG10118
uniprot id: B5X0J4
uniprot id: P18459
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Phosphorylation leads to an increase in the catalytic activity.
messages: Plays an important role in the physiology of adrenergic neurons.
messages: axon
messages: perinuclear region

7227:Dmel CG14812
gene id: 7227:Dmel_CG14812
uniprot id: O96824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

7227:Dmel CG9870
gene id: 7227:Dmel_CG9870
uniprot id: Q9VQB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

7227:Dmel CG3692
gene id: 7227:Dmel_CG3692
uniprot id: Q9VXH6
uniprot id: T2GFF8
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although strongly related to peptidase C2 proteins, it lack the essential Cys, His and Asn residues of the catalytic triad at positions 84, 242 and 267, respectively.
messages: Belongs to the peptidase C2 family.
messages: Cytoplasm
messages: Expressed throughout development, with expression highest in the pupa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Localized to the salivary glands in the larva.
messages: Not known; does not seem to have protease activity.

7227:Dmel CG9198
gene id: 7227:Dmel_CG9198
uniprot id: Q9VXV3
names: Similarity
messages: Belongs to the APC1 family.

7227:Dmel CG7571
gene id: 7227:Dmel_CG7571
uniprot id: Q9VVH9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Development is arrested at the end of the first instar larval stage (PubMed:30293839). RNAi-mediated knockdown blocks ecdysone-dependent fat body cell migration into the pupal head (PubMed:30293839). In the fat body, results in defective ecdysone signaling (PubMed:30293839).
messages: Expressed ubiquitously during development in central nervous system, imaginal disk, fat body, gut, and to a lesser extent in Malpighian tubules.
messages: Transporter that mediates the cellular uptake of ecdysteroids, including ecdysone, from the hemolymph.

7227:Dmel CG7808
gene id: 7227:Dmel_CG7808
uniprot id: A0A0B4K6N1
uniprot id: Q8MLY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

7227:Dmel CG6649
gene id: 7227:Dmel_CG6649
uniprot id: Q9VGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7227:Dmel CG31671
gene id: 7227:Dmel_CG31671
uniprot id: E2QCS8
uniprot id: M9PE28
uniprot id: Q9VQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

7227:Dmel CG13995
gene id: 7227:Dmel_CG13995
uniprot id: Q9VMI4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG1502
gene id: 7227:Dmel_CG1502
uniprot id: D3PFG0
uniprot id: P54356
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the twisted gastrulation protein family.
messages: Component of a complex composed of dpp, sog and tsg.
messages: First appears in stage 4 embryos, expressed in two domains: a broad mid-dorsal saddle and an anterior cap, expression between the domains is continuous across the dorsal midline. At stage 5, expression is refined into 4 graded stripes in the mid-dorsal region and a paired domain in the anterior region. During stages 7 and 8, anterior expression fades and the mid dorsal stripes are located between the anterior and posterior transverse furrow (ATF and PTF). Expressing cells become incorporated into the deepening PTF.
messages: Gastrulating embryo.
messages: Involved in dorsal-ventral patterning. Required for specification of a narrow strip of dorsal midline cells that will give rise to the amnioserosa, but not for specification of dorsal ectoderm cells. Inhibits BMP signaling; enhances the binding of sog to dpp, thus enhancing the antagonistic activity of sog.
messages: Secreted

7227:Dmel CG13784
gene id: 7227:Dmel_CG13784
uniprot id: M9PCE7
uniprot id: M9PCT0
uniprot id: M9PEZ6
uniprot id: Q0E8S5
uniprot id: Q8T9A4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG5344
gene id: 7227:Dmel_CG5344
uniprot id: Q9VGL8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cytoplasmic vesicle
messages: Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.
messages: RNAi-mediated knockdown in the trachea results in a U-turn phenotype in which the seamless tubes undergo a series of 180 degree turns in terminal tip cells.
messages: filopodium

7227:Dmel CG12346
gene id: 7227:Dmel_CG12346
uniprot id: Q7JR24
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8230
gene id: 7227:Dmel_CG8230
uniprot id: Q7KNA0
names: Similarity
messages: Belongs to the dymeclin family.

7227:Dmel CG3772
gene id: 7227:Dmel_CG3772
uniprot id: O77059
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to bind 5,10-methenyltetrahydrofolate at substoichiometric levels.
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit. The bound form of FAD in the inactive state of cry is oxidized FAD, not reduced. After activation by blue light the FAD is in an anionic radical state, which would be paramagnetic. Green light, which reduces levels of radical intermediate, has an antagonistic effect on function.
messages: Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.
messages: Cytoplasm
messages: Expressed at higher levels in the head than in body and it is more expressed in antennae than in legs, wings and mouth appendages. Prominent expression is seen in cells of the lateral brain, which are close to or coincident with the clock neurons. Abundance oscillates in a circadian manner.
messages: Expression is regulated by light and circadian rhythms. Under circadian regulation, expression is influenced by the clock pacemaker genes period, timeless, Clock and cycle.
messages: FAD-binding region regulates cry stability, cry-tim interaction, and circadian photosensitivity.
messages: Flies exhibit poor synchronization to light-dark cycles and show no response to brief light pulses. Mutant abolishes rhythmic tim and per expression in photoreceptor and glial cells, but not within certain pacemaker neurons of adult brain.
messages: Interacts with tim and per; promoted by light conditions (PubMed:10417378, PubMed:11448767). Interaction with tim irreversibly commits tim to proteasomal degradation (PubMed:10417378). Interacts with l(1)G0136/CG8198 (PubMed:26569474).
messages: Nucleus
messages: Photolyase/cryptochrome alpha/beta domain is sufficient for light detection and phototransduction.
messages: Unstable upon light exposure. Light induces the degradation of cry, likely due to conformational change in the photoreceptor leading to targeting to the proteasome.
messages: perinuclear region

7227:Dmel CG32632
gene id: 7227:Dmel_CG32632
uniprot id: A8JUV2
uniprot id: M9PEH9
uniprot id: M9PHI3
uniprot id: Q9VYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (By similarity). Has a role in protein secretion.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

7227:Dmel CG4108
gene id: 7227:Dmel_CG4108
uniprot id: Q95SH2
names: Similarity
messages: Belongs to the SNF7 family.

7227:Dmel CG2358
gene id: 7227:Dmel_CG2358
uniprot id: O97066
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

7227:Dmel CG8631
gene id: 7227:Dmel_CG8631
uniprot id: P50536
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3.
messages: Nucleus
messages: The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding.

7227:Dmel CG33349
gene id: 7227:Dmel_CG33349
uniprot id: A1Z6S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG6620
gene id: 7227:Dmel_CG6620
uniprot id: Q9VKN7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Interacts with Incenp and Cdc37.
messages: Midbody
messages: Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates mei-S332 within residues 124-126 and stabilizes its association with centromeres during meiosis.
messages: Ubiquitously expressed at very high levels in embryo. Expressed at low levels during larval stages, and at higher levels in female adults (at protein level).
messages: cytoskeleton

7227:Dmel CG9148
gene id: 7227:Dmel_CG9148
uniprot id: Q8IRH7
uniprot id: Q9W0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

7227:Dmel CG5905
gene id: 7227:Dmel_CG5905
uniprot id: Q9W436
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Expressed in the testicular tube, near and in the seminal vesicles. In adults and third-instar larvae, expressed in the midgut and in the mushroom bodies of the brain and neurons in the pars intercerebralis. Also expressed in neurons of the ventral ganglion and imaginal disks (wing and leg) of third-instar larvae. In stage 17 embryos, expressed in the peripheral nervous system, pharynx and midgut.
messages: Metalloendoprotease which functions in fertility and memory formation (PubMed:24395329, PubMed:27629706). Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories (PubMed:27629706). Required in males to maximise egg-laying in female mates and is also required in females for their fertility (PubMed:24395329).
messages: RNAi-mediated knockdown females lay fewer eggs and display a reduced hatch rate when mated to wild-type males, and wild-type females lay fewer eggs when mated to RNAi-mediated knockdown males (PubMed:24395329). RNAi-mediated knockdown in the dorsal paired medial neurons impairs middle-term (MTM) and long-term memory (LTM), but has no effect on normal aversion learning and anesthesia-resistant memory (ARM) (PubMed:27629706). RNAi-mediated knockdown in alpha/beta mushroom body neurons impairs MTM and LTM (PubMed:27629706). RNAi-mediated knockdown in all mushroom body neurons has no effect on learning and ARM (PubMed:27629706).

7227:Dmel CG5733
gene id: 7227:Dmel_CG5733
uniprot id: A1YK02
uniprot id: A1YK08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Facilitates the interaction between Nup93 and sec13 with msk (PubMed:20547758).
messages: Component of the nuclear pore complex (NPC).
messages: Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

7227:Dmel CG14275
gene id: 7227:Dmel_CG14275
uniprot id: Q9VLP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Belongs to the scoloptoxin-05 family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG7309
gene id: 7227:Dmel_CG7309
uniprot id: Q7KTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

7227:Dmel CG6621
gene id: 7227:Dmel_CG6621
uniprot id: Q9VGU5
names: Similarity
messages: Belongs to the TTC14 family.

7227:Dmel CG9748
gene id: 7227:Dmel_CG9748
uniprot id: A0A0H4XWW0
uniprot id: Q9VHP0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility. Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: Expressed throughout development, highest expression in second larval instar and adult females.
messages: Flies are recessive lethal with a larval growth defect phenotype. Hypomorphic bel mutants are male-sterile due to defects in spermatogenesis and female sterile as oogenesis usually arrests around stages 8-9 and egg chambers completely degenerate.
messages: Vas and bel colocalize in nuage (perinuclear, electron-dense granules in germline cells) and at the oocyte posterior during oogenesis.

7227:Dmel CG17569
gene id: 7227:Dmel_CG17569
uniprot id: Q8IRE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

7227:Dmel CG9981
gene id: 7227:Dmel_CG9981
uniprot id: Q9VXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7227:Dmel CG9235
gene id: 7227:Dmel_CG9235
uniprot id: Q9W2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Membrane

7227:Dmel CG15814
gene id: 7227:Dmel_CG15814
uniprot id: Q8IQZ5
uniprot id: Q9VX13
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG4528
gene id: 7227:Dmel_CG4528
uniprot id: P43332
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM U1 A/B'' family.
messages: Belongs to the spliceosome where it is associated with snRNP U1. Interacts with the SMN complex.
messages: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing.
messages: Nucleus

7227:Dmel CG1691
gene id: 7227:Dmel_CG1691
uniprot id: M9NF14
uniprot id: Q0KHU2
names: Similarity
messages: Belongs to the RRM IMP/VICKZ family.

7227:Dmel CG3456
gene id: 7227:Dmel_CG3456
uniprot id: Q9W509
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32263
gene id: 7227:Dmel_CG32263
uniprot id: Q8IRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7227:Dmel CG6218
gene id: 7227:Dmel_CG6218
uniprot id: Q9VF86
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

7227:Dmel CG33881
gene id: 7227:Dmel_CG33881
uniprot id: P84040
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG9666
gene id: 7227:Dmel_CG9666
uniprot id: Q8MSW4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Catalytic subunit of a heterodimer with Trmt112/CG12975, which specifically methylates the 6th position of adenine in 18S rRNA.
messages: Cytoplasm
messages: Enriched in the brain.
messages: Expressed at high level in early embryo. Expression gradually decreases and remains low in the larval stages. A mild increase is observed at metamorphosis, and this level remains constant in the adult phase.
messages: Flies are viable and fertile and do not display obvious developmental defects (PubMed:32350990). They however show impaired orientation in walking behavioral assays (PubMed:32350990).
messages: Heterodimer; heterodimerizes with Trmt112/CG12975.

7227:Dmel CG9953
gene id: 7227:Dmel_CG9953
uniprot id: Q9VS02
names: Similarity
messages: Belongs to the peptidase S28 family.

7227:Dmel CG2807
gene id: 7227:Dmel_CG2807
uniprot id: Q9VPR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

7227:Dmel CG1041
gene id: 7227:Dmel_CG1041
uniprot id: A0A126GUQ4
uniprot id: Q0KIA8
uniprot id: Q9VI16
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7227:Dmel CG3068
gene id: 7227:Dmel_CG3068
uniprot id: Q9VGF9
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

7227:Dmel CG1897
gene id: 7227:Dmel_CG1897
uniprot id: Q03372
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Msh homeobox family.
messages: Dorsal lateral ectoderm, developing central and peripheral nervous systems and the somatic mesoderm. Expressed in dorsal and lateral muscle preclusters and mesodermal fat body precursors.
messages: Embryo, between 4 hours and larval first instar whereupon expression is greatly reduced. Continued expression only in the CNS up until hatching.
messages: Nucleus
messages: Plays a key role in the specification of proneural and promuscular cluster formation (PubMed:8887329, PubMed:9486795). Required for the specification of dorsal and lateral muscle progenitor cells (PubMed:8887329, PubMed:9486795). Regulates development of peripheral nervous system derived from lateral neuroblasts (PubMed:28716930).

7227:Dmel CG32797
gene id: 7227:Dmel_CG32797
uniprot id: Q8IRW0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG7922
gene id: 7227:Dmel_CG7922
uniprot id: Q9VDA0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

7227:Dmel CG12943
gene id: 7227:Dmel_CG12943
uniprot id: Q4V5R4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Expressed in the hemolymph of larvae and adults.
messages: Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli.
messages: RNAi-mediated knockdown in adult blood cells results in decreased survival following infection with S.aureus. Adults infected with S.aureus display decreased phagocytosis, increased bacterial load and increased production of reactive oxygen species (ROS) in the hemolymph. Phagocytosis of latex beads is normal, however flies pre-injected with S.aureus display a significant decrease in subsequent bead phagocytosis. Increased survival following infection with L.monocytogenes. Increased extracellular glutamate in the hemolymph. No effect on motor functions, adult weight and no increase in susceptibility to wounding. Induction of the antimicrobial peptides Drs and DptA in response to S.aureus or E.coli infection is not affected.
messages: The name 'polyphemus' derives from the Cyclops in Greek mythology that failed to guard against Odysseus as mutants are unable to defend against microbial infection.

7227:Dmel CG11147
gene id: 7227:Dmel_CG11147
uniprot id: Q9VMM9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG11994
gene id: 7227:Dmel_CG11994
uniprot id: Q9VHH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
messages: Monomer.

7227:Dmel CG2827
gene id: 7227:Dmel_CG2827
uniprot id: B3DMP7
uniprot id: Q9W1G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

7227:Dmel CG33863
gene id: 7227:Dmel_CG33863
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG32488
gene id: 7227:Dmel_CG32488
uniprot id: Q8SXC9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

7227:Dmel CG6719
gene id: 7227:Dmel_CG6719
uniprot id: Q9VGP6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl.
messages: Cytoplasm
messages: Expressed in larval central nervous system (CNS) and pupal testis (at protein level).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits (By similarity). Interacts with itself. Interacts with Vhl and betaTub56D/tubulin beta-1 chain. Interacts with tubulin alpha-beta heterodimers by itself or in complex with Vhl. Does not interact with microtubules (MTs).
messages: Pupal lethal. Most mutants die just before emergence from the pupal case. In mutant larval CNS, neuroblasts show bipolar spindles that may lack one or both centrosomes or monopolar spindles having one or two centrosomes at the single pole. The mitotic index is elevated twofold over that in wild-type larval brains and the ratio of metaphase:anaphase two- to threefold over wild-type. Mutant neuroblasts also show a decrease of 25% in betaTub56D/tubulin beta chain-1 expression. Mutant mature primary spermatocytes show impaired MT network resulting in meiotic spindles either absent or highly abnormal. In mutant testis, decreased expression of betaTub85D/tubulin beta-2 chain is observed.

7227:Dmel CG5548
gene id: 7227:Dmel_CG5548
uniprot id: Q9VXZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

7227:Dmel CG7887
gene id: 7227:Dmel_CG7887
uniprot id: A0A0B4KHV8
uniprot id: E1JJ17
uniprot id: P30975
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: During late embryogenesis (stages 11-15), expressed in the brain and in a specific subset of neurons in each neuromere of the developing ventral ganglion. Expressed in the cortex of the adult brain, which contains the neuronal cell bodies.
messages: Expressed throughout development and in the adult. Highest level of expression observed during late embryogenesis.
messages: Membrane
messages: Receptor for tachykinin-like peptides.

7227:Dmel CG10318
gene id: 7227:Dmel_CG10318
uniprot id: Q9W2E3
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG6540
gene id: 7227:Dmel_CG6540
uniprot id: Q9VWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154 (PubMed:22718353).
messages: Interacts with Nup154.
messages: nuclear pore complex

7227:Dmel CG18324
gene id: 7227:Dmel_CG18324
uniprot id: A1Z9M0
uniprot id: Q7K2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG8031
gene id: 7227:Dmel_CG8031
uniprot id: Q9VG04
names: Similarity
messages: Belongs to the MEMO1 family.

7227:Dmel CG4673
gene id: 7227:Dmel_CG4673
uniprot id: Q9VBP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPL4 family.
messages: Interacts with TER94.
messages: May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.

7227:Dmel CG9282
gene id: 7227:Dmel_CG9282
uniprot id: Q9VJY6
uniprot id: X2JE06
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

7227:Dmel CG3800
gene id: 7227:Dmel_CG3800
uniprot id: Q8T8R1
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with active polyribosomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: RNAi-mediated knockdown results in lethality before the pupal stage (PubMed:24275942). RNAi-mediated knockdown in the wing imaginal disks results in reduction of wing size associated with loss of patterning elements such as veins; this phenotype is reversed by Myc overexpression (PubMed:24275942).
messages: Single-stranded DNA/RNA-binding protein with sequence specificity (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity). IRES trans-acting factor (ITAF) that can promote IRES-dependent translation of Myc mRNA (PubMed:24275942). Involved in the control of wing size by regulating Myc levels (PubMed:24275942).

7227:Dmel CG16783
gene id: 7227:Dmel_CG16783
uniprot id: Q9W1F6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

7227:Dmel CG31009
gene id: 7227:Dmel_CG31009
uniprot id: Q9VAF5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794). Essential for female fertility (PubMed:16260500, PubMed:16507588). Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597). Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597). Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597). Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992). May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992). Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992). In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
messages: Endosome membrane
messages: Females display reduced fertility as well as defective eggshell development (PubMed:16260500). Ovarian follicle cell microvilli are abnormally shaped and display a range of defects including decreased length, reduced number and an irregular distribution pattern, leading to impaired vitelline membrane formation (PubMed:16260500, PubMed:16507588). In the intestines of 3-day old adults there is no formation of endosomes and consequently no DUOX-dependent up-regulation of reactive oxygen species (ROS) in response to the ingestion of bacteria-derived uracil (PubMed:25639794). Embryos display irregular cell rearrangements during salivary gland development with fewer cells surrounding the salivary gland lumens and lumens appear to be elongated (PubMed:24718992).
messages: Interacts (via the cytoplasmic domain) with ck (PubMed:25236597, PubMed:27331610). Interacts (via the cytoplasmic domain) with Cul1 and Ubr3 (PubMed:27331610).
messages: Low expression throughout the imaginal disks of third instar larvae with higher levels of expression at the anterior-posterior boundary (at protein level) (PubMed:15708564). Detected in the germarium and stage 2 and stage 3 egg chambers (at protein level) (PubMed:16507588). From stages 2 to 8, expressed in the follicle cells at the anterior and posterior poles of the egg chambers (at protein level) (PubMed:16260500, PubMed:16507588). From stage 4 to the end of oogenesis, only detected in follicle cells that are in contact with the oocyte (at protein level) (PubMed:16260500, PubMed:16507588). From stage 11 expressed at the apical surface of several embryonic tubular organs including the salivary glands, trachea, foregut and hindgut (PubMed:24718992).
messages: The cytoplasmic domain is necessary for the formation of uracil-induced endosomes.
messages: The extracellular domain is necessary for conferring apical characteristics on the salivary gland membrane (PubMed:24718992). Necessary for regulating salivary gland membrane expansion and tube length, but is not required for cell rearrangement during tube elongation (PubMed:24718992). Sufficient to promote the outgrowth of follicle cell microvilli and the formation of microvilli bundles (PubMed:16260500, PubMed:24718992) Sufficient to promote formation of microvilli-like structures in the salivary glands and the follicle cell microvilli bundles (PubMed:16507588, PubMed:24718992). Dispensable for apical localization (PubMed:24718992).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain (By similarity).
messages: Up-regulated in the adult anterior midgut after the ingestion of bacterial uracil. Strong up-regulation detected 1 hour, 2 hours and 16 hours after ingestion, whereas no up-regulation was detected at 4 hours.
messages: microvillus membrane

7227:Dmel CG13617
gene id: 7227:Dmel_CG13617
uniprot id: Q9VC70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: Component of a ciliary transition zone (TZ)-localized complex composed of DZIP1, Fam92 and Cby (PubMed:31821146). Interacts directly with Cby (PubMed:31821146, PubMed:33370260). Interacts with cep290 (via N-terminus) (PubMed:33370260). Interacts (via N-terminus) with Rab8 (PubMed:33370260).
messages: Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly (PubMed:31821146, PubMed:33370260). During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules (PubMed:31821146). Within the complex, required to recruit or stabilize Rab8, Fam92 and Cby at the distal basal body of cilia to promote early ciliary membrane formation and initiate TZ assembly (PubMed:31821146). Also acts with Fam92 to restrict cep290 localization to the proximal part of the TZ (PubMed:31821146). May also be involved in recruitment or stabilization of Mks1 at the TZ (PubMed:31821146).
messages: In neurons of the second and third antennal segments, expressed at the tip of the dendrites.
messages: centriole
messages: cilium basal body

7227:Dmel CG1318
gene id: 7227:Dmel_CG1318
uniprot id: Q0E8H9
uniprot id: Q8IRB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

7227:Dmel CG4467
gene id: 7227:Dmel_CG4467
uniprot id: Q0KI25
uniprot id: Q9VCP4
names: Similarity
messages: Belongs to the peptidase M1 family.

7227:Dmel CG10345
gene id: 7227:Dmel_CG10345
uniprot id: Q9VET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG8142
gene id: 7227:Dmel_CG8142
uniprot id: Q9VX15
names: Similarity
messages: Belongs to the activator 1 small subunits family.

7227:Dmel CG6337
gene id: 7227:Dmel_CG6337
uniprot id: Q7JYA0
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG9588
gene id: 7227:Dmel_CG9588
uniprot id: Q9VFS8
names: Function
names: Similarity
names: Subunit
messages: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC).
messages: Belongs to the proteasome subunit p27 family.
messages: Interacts with PI31; this interaction is increased by PI31 ADP-ribosylation. Interacts with Rpt5.

7227:Dmel CG3955
gene id: 7227:Dmel_CG3955
uniprot id: Q7K2X4
names: Similarity
messages: Belongs to the scoloptoxin-05 family.

7227:Dmel CG33197
gene id: 7227:Dmel_CG33197
uniprot id: O16011
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aberrant splicing.
messages: Belongs to the muscleblind family.
messages: Expressed in embryonic muscle cells.
messages: Nucleus
messages: Required for terminal differentiation of photoreceptor cells. Vital for embryonic development.

7227:Dmel CG18268
gene id: 7227:Dmel_CG18268
uniprot id: Q9VHZ8
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG8072
gene id: 7227:Dmel_CG8072
uniprot id: Q9VT82
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG42385
gene id: 7227:Dmel_CG42385
uniprot id: C0HJX4
uniprot id: C0HJX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: At early stages of embryogenesis, the polycistronic RNA is expressed in seven segmentally separated blastoderm stripes and in a cluster of cells in the anterior part of the embryo (PubMed:17439302). By stage 13 to the end of embryo development, it is expressed in the dorsal trunks, posterior spiracles, pharynx, hindgut and the area which forms the denticle belts (PubMed:17439302). In the leg disk, it is expressed in a ring pattern presumed to be developing tarsal region around 80 to 96 h after egg laying (AEL) and then in the tarsal furrow at the mid-third instar larval stage (PubMed:17439302, PubMed:18801356). Not detected in the tarsal primordium after 100h AEL but is still expressed in a dorsal chordotonal organ of the leg disk (PubMed:17439302). In pupae, expressed broadly throughout the leg disk 0-3 h after puparium formation (APF) but is not detected in this region 6h APF (PubMed:25344753). High expression 4-8 h APF in the presumptive joints between tarsal segments (PubMed:21682860). In the noctum expressed from 40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae, expressed in two anterior stripes and later in the precursors for chemosensory organs (PubMed:21682860). From late third stage instar larvae to early pupal stages, it is also expressed in the wing provein cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In eye disks, expressed in preclusters for presumptive R8 photoreceptors and in a stripe of cells in the posterior region of the disk (PubMed:21682860).
messages: Cytoplasm
messages: Interacts with Ubr3.
messages: Nucleus
messages: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114).
messages: Polycistronic RNA up-regulated by ecdysone.
messages: Simultaneous knockout of tal-1A, tal-2A, tal-3A and tal-AA is embryonic lethal (PubMed:17439302, PubMed:17486114). In embryos chitin secretion and formation of the cuticular exoskeleton appears to be normal (PubMed:17439302, PubMed:17486114). However embryos display a loss of denticle belts and dorsal hairs (PubMed:17439302, PubMed:17486114). Segment-specific epidermal sensory organs are present and segments form normally (PubMed:17439302). The cephalopharyngeal skeleton is lost, and the head skeleton and posterior spiracles are deformed (PubMed:17439302). In the developing leg, tarsal constriction occurs but the tarsal fold does not form (PubMed:17439302). The tracheal system is abnormal displaying a loss of network integrity, an irregular tube diameter and the absence of taenidial folds (PubMed:17439302, PubMed:17486114). Cell packing is not affected, but there is no accumulation of F-actin at the sites of denticle differentiation or formation of F-actin bundles during taenidial development and tracheal tube dilation (stages 14 and 16) (PubMed:17486114). Other F-actin based developmental processes such as filopodia formation of tracheal tip cells, dorsal closure, mitosis or tight packing of denticle cells are unaffected (PubMed:17486114). Denticle and tracheal defects can be rescued by ectopic expression of any one of the four tal peptides (tal-1A, tal-2A, tal-3A and tal-AA) (PubMed:17486114).
messages: This protein is produced by a polycistronic gene which also produces tal-1A, tal-3A and tal-AA from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).
messages: This protein is produced by a polycistronic gene which also produces tal-2A, tal-3A and tal-AA from non-overlapping reading frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce the same protein from different reading frames (PubMed:17486114, PubMed:17439302).

7227:Dmel CG4586
gene id: 7227:Dmel_CG4586
uniprot id: Q9W3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

7227:Dmel CG6493
gene id: 7227:Dmel_CG6493
uniprot id: A0A0B4LFK8
uniprot id: A1ZAW0
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.

7227:Dmel CG4878
gene id: 7227:Dmel_CG4878
uniprot id: E2QCG7
uniprot id: Q0E940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix (PubMed:17392269). Interacts with mxt (PubMed:23716590).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

7227:Dmel CG15259
gene id: 7227:Dmel_CG15259
uniprot id: Q9VJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

7227:Dmel CG43194
gene id: 7227:Dmel_CG43194
uniprot id: A0A0B4K753
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Early endosome membrane
messages: Expressed in hemocytes.
messages: Expression increases from prepupal to adult stages.
messages: Interacts with 14-3-3zeta.
messages: Mutants reach adulthood and show no overt morphological defects but their hemocytes display a more vacuolated morphology than controls with enlarged endolysosomes which accumulate undigested phagocytic material due to impaired digestion. This leads to decreased resistance to bacterial infection and severely reduced lifespan.
messages: Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing.

7227:Dmel CG3911
gene id: 7227:Dmel_CG3911
uniprot id: Q9VSY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

7227:Dmel CG12210
gene id: 7227:Dmel_CG12210
uniprot id: P18489
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptobrevin family.
messages: Cell lethality.
messages: Cell membrane
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
messages: Not nervous system-specific; abundant in cells of the gut and Malpighian tubules.
messages: Part of the SNARE core complex containing Snap25 and syntaxin.
messages: Ubiquitinated by gzl, regulating endocytic trafficking (PubMed:23353890). In wing imaginal disks, ubiquitination by gzl promotes transcytosis of wingless (wg) to the basolateral surface (PubMed:26974662).
messages: synaptic vesicle membrane

7227:Dmel CG12730
gene id: 7227:Dmel_CG12730
uniprot id: Q9W4B6
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7893
gene id: 7227:Dmel_CG7893
uniprot id: Q9NHV9
names: Developmental Stage
names: Function
names: PTM
names: Subunit
names: Tissue Specificity
messages: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.
messages: Expressed both maternally and zygotically in all stages of development.
messages: Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).
messages: Phosphorylated on tyrosine residues.
messages: Ubiquitous.

7227:Dmel CG7408
gene id: 7227:Dmel_CG7408
uniprot id: Q9VVM1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG9084
gene id: 7227:Dmel_CG9084
uniprot id: A0A0B4KEL2
uniprot id: A0A0B4LF35
uniprot id: A1Z8F5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7227:Dmel CG5884
gene id: 7227:Dmel_CG5884
uniprot id: O97111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

7227:Dmel CG9125
gene id: 7227:Dmel_CG9125
uniprot id: Q9VXA8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control.

7227:Dmel CG4088
gene id: 7227:Dmel_CG4088
uniprot id: Q7K2L1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

7227:Dmel CG11301
gene id: 7227:Dmel_CG11301
uniprot id: Q9W256
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Has a role in cell cycle progression (PubMed:19150446). Required for wing morphogenesis (PubMed:19150446).
messages: Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit PolE1/DNApol-epsilon255 and the accessory subunits PolE2/DNApol-epsilon58, Chrac-14/DNApolE3 and PolE4/Mes4.
messages: Expressed throughout all developmental stages (PubMed:19150446). In the third instar larva expressed in fat bodies, brain lobes, eye-antenna imaginal disks, wing imaginal disks, salivary glands and ovaries (PubMed:19150446).
messages: Nucleus
messages: RNAi-mediated knockdown results in an atrophied wing phenotype characterized by increased induction of cell proliferation in wing disks but failed cell cycle progression.

7227:Dmel CG12163
gene id: 7227:Dmel_CG12163
uniprot id: H5V8F3
uniprot id: Q9VN93
names: Function
names: Similarity
messages: Belongs to the peptidase C1 family.
messages: May have a role in autophagic cell death.

7227:Dmel CG42865
gene id: 7227:Dmel_CG42865
uniprot id: H9TV77
uniprot id: M9PBG9
uniprot id: M9PDI8
uniprot id: M9PDQ7
uniprot id: M9PE27
uniprot id: Q24119
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: During embryogenesis, first detected in the tracheal placodes at stage 8, and expression continues throughout embryonic and larval development. In the developing salivary gland, expression is observed in the entire gland at stage 9 and by stage 12, expression is confined to the salivary ducts.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with tgo.
messages: Nucleus
messages: Readthrough of the terminator UGA may occur between the codons for 958-Ser and 960-Val.
messages: Ser-673 phosphorylation by PKB/Akt1 is required for nuclear targeting and transcriptional activity.
messages: Trachea, salivary gland ducts, posterior spiracles (Filzkoeper primordia) and a subset of cells in the CNS.
messages: Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles (PubMed:8557189, PubMed:8557198, PubMed:9374395, PubMed:10502111). It may induce a general fate of branched tubular structures of epithelial origin (PubMed:8557189, PubMed:8557198, PubMed:10502111). Functions with tgo to regulate expression of btl (PubMed:9374395).
messages: Tube-forming cells of the salivary gland, trachea, and filzkorper fail to invaginate to form tubes and remain on the embryo surface (PubMed:8557189). In embryo Malpighian tubules, cell rearrangement is incomplete and the resulting tubules are wider than normal (PubMed:10502111).

7227:Dmel CG7986
gene id: 7227:Dmel_CG7986
uniprot id: M9PER1
uniprot id: M9PEY7
uniprot id: M9PHS3
uniprot id: Q9VSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

7227:Dmel CG6798
gene id: 7227:Dmel_CG6798
uniprot id: H5V857
uniprot id: P25162
names: Caution
names: Developmental Stage
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: CNS in embryos.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Late embryonic and late pupal stages.
messages: Membrane
messages: Partially edited.
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG33858
gene id: 7227:Dmel_CG33858
uniprot id: Q4AB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

7227:Dmel CG10545
gene id: 7227:Dmel_CG10545
uniprot id: A4V4I0
uniprot id: P26308
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat G protein beta family.
messages: Expressed throughout development.
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: In adults, expression is higher in the head than in the body.

7227:Dmel CG1856
gene id: 7227:Dmel_CG1856
uniprot id: P17789
uniprot id: P42282
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to a number of sites in the transcriptional regulatory region of ftz (PubMed:2104801). Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates (PubMed:12384587, PubMed:18160715). Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en (PubMed:8223261). Inhibits Trl-dependent activation of eve (PubMed:12384587). May bind to the region AGGGC/TGG (PubMed:8247159). Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk (PubMed:18160715, PubMed:17962185). A second method of degradation exists that is phyl-independent, this is mediated by recognition of motifs in the C-terminus of ttk (PubMed:17962185).
messages: Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk.
messages: Can form homodimers (PubMed:12384587). Interacts with Trl in vivo via the BTB domain (PubMed:12384587). Interacts with phyl (PubMed:17962185). Interacts with Usp47 (PubMed:18160715).
messages: Expressed both maternally and zygotically. Expressed in preblastoderm embryos, followed by complete decay upon formation of the cellular blastoderm when ftz striped expression is at its peak.
messages: Interacts with CoRest/CG33525, suggesting that it acts by recruiting a CoRest-containing corepressor complex. Interacts with phyl.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Nucleus
messages: Polyubiquitinated by sina. Polyubiquitin linkage is mainly through 'Lys-48', but linkage through 'Lys-63' also occurs. Deubiquitination by Usp47 leads to its stabilization.

7227:Dmel CG4123
gene id: 7227:Dmel_CG4123
uniprot id: Q9VV72
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (PubMed:26628373). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches (PubMed:26628373). In these leading cells, enhances formation and/or maintenance of filopodia which may drive branch migration and elongation by cell-cell intercalation (PubMed:26628373). The function in tracheal morphogenesis is dependent on its inositol polyphosphate phosphatase activity (PubMed:26628373).
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
messages: Cell junction
messages: Cell membrane
messages: During embryonic stage 10-12, expressed throughout the tracheal primordia. At stages 13-15, expression is lost from the tracheal dorsal trunks (DTs) but is maintained in branches still undergoing active elongation and migration: the dorsal branches (DBs), visceral branches (VBs), lateral trunk branches (LTs) and ganglionic branches (GBs). Notably, expression is enriched at regions of filopodia formation such as the distal tips of the DBs, LTs and GBs.
messages: N-glycosylated.
messages: Tracheal morphology is grossly normal although some defects are observed. Dorsal trunks (DTs) are significantly elongated, and dorsal branches (DBs) frequently fail to fuse with their contralateral partner. Filopodia number in DBs is reduced.
messages: Up-regulated by FGF signaling in the developing trachea.
messages: filopodium

7227:Dmel CG18271
gene id: 7227:Dmel_CG18271
uniprot id: Q9VN41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with mus312/SLX4.
messages: Nucleus

7227:Dmel CG5803
gene id: 7227:Dmel_CG5803
uniprot id: P15278
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed on different subsets of axon bundles (fascicles) in insect embryos.
messages: Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system.
messages: Membrane

7227:Dmel CG2023
gene id: 7227:Dmel_CG2023
uniprot id: Q9VNI9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG18747
gene id: 7227:Dmel_CG18747
uniprot id: Q9I7L1
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG5414
gene id: 7227:Dmel_CG5414
uniprot id: Q9VUY4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7227:Dmel CG5304
gene id: 7227:Dmel_CG5304
uniprot id: Q9VKC9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG9630
gene id: 7227:Dmel_CG9630
uniprot id: Q9VHU1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Probable ATP-binding RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7227:Dmel CG4347
gene id: 7227:Dmel_CG4347
uniprot id: A5XCL5
uniprot id: E1JI91
uniprot id: Q9VSW1
uniprot id: Q9VSW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

7227:Dmel CG8739
gene id: 7227:Dmel_CG8739
uniprot id: Q8IGJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: An essential gene required for embryogenesis; required for cell viability.
messages: Belongs to the EFR3 family.
messages: Expression during embryogenesis is ubiquitous with notably higher levels in the CNS and brain.
messages: Membrane

7227:Dmel CG17868
gene id: 7227:Dmel_CG17868
uniprot id: I6LTT3
uniprot id: Q9V3Q2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
messages: Cell membrane
messages: Expressed in ac3B olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG8900
gene id: 7227:Dmel_CG8900
uniprot id: P41094
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Cytoplasm
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

7227:Dmel CG10157
gene id: 7227:Dmel_CG10157
uniprot id: Q9VCK1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Probable lysosomal thiol reductase that can reduce protein disulfide bonds (By similarity). Involved in the immune response to bacterial infection (PubMed:24491521).
messages: RNAi-mediated knockdown in the fat body or hemocyte of flies infected with the Gram-negative bacterium E.coli results in an increase in bacterial load 24 hours after infection.
messages: Secreted
messages: Up-regulated following injection with the Gram-negative bacterium E.coli. Up-regulation increases between 1 and 12 hours after the injection, then decreases between 12 and 48 hours, and then increases again at 72 hours.

7227:Dmel CG4725
gene id: 7227:Dmel_CG4725
uniprot id: Q9VCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG17562
gene id: 7227:Dmel_CG17562
uniprot id: Q9VES7
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

7227:Dmel CG5671
gene id: 7227:Dmel_CG5671
uniprot id: Q7KMQ6
uniprot id: Q9V3L4
uniprot id: Q9Y0B6
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

7227:Dmel CG10739
gene id: 7227:Dmel_CG10739
uniprot id: Q24118
names: Developmental Stage
names: Miscellaneous
names: Similarity
messages: 'Linotte' used in the colloquial sentence 'Tete de linotte' literally means 'Scatterbrain' in French.
messages: Belongs to the GSAP family.
messages: Detected in embryos, pupae, and adults but not larvae.

7227:Dmel CG6422
gene id: 7227:Dmel_CG6422
uniprot id: Q9VBZ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YTHDF family.
messages: Cytoplasm
messages: Interacts with Fmr1; the interaction is RNA independent.
messages: Results in fusion of the adult Beta lobes in the mushroom bodies.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:28675155, PubMed:33428246). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability (PubMed:28675155, PubMed:33428246). Together with Fmr1, regulates axonal growth in the mushroom bodies and neuromuscular junctions by repressing the translation of several mRNAs, such as those of chic and futsch (PubMed:33428246).
messages: Strongly enriched during the first 2 hours after fertilization but then declines and remains at low levels during development and adulthood.

7227:Dmel CG12505
gene id: 7227:Dmel_CG12505
uniprot id: Q7K1U0
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ARC/ARG3.1 family.
messages: Expressed in a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage.
messages: Extracellular vesicle membrane
messages: Homooligomer; homooligomerizes into virion-like capsids.
messages: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).
messages: Strong reduction in the number of synaptic boutons at neuromuscular junction in third-instar larvae.
messages: Synapse
messages: The protein is evolutionarily related to retrotransposon Gag proteins (PubMed:29328915, PubMed:29328916). It contains structural elements found within viral Gag polyproteins originated from the Ty3/gypsy retrotransposon family and retains the ability to form virion-like capsid structures that can mediate mRNA transfer between cells (PubMed:29328915, PubMed:29328916). Tetrapod and fly Arc protein-coding genes originated independently from distinct lineages of Ty3/gypsy retrotransposons (PubMed:29328916).
messages: Up-regulated following stimulation of E347 brain neurons.

7227:Dmel CG33934
gene id: 7227:Dmel_CG33934
uniprot id: E1JIQ7
uniprot id: Q0KI47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

7227:Dmel CG42701
gene id: 7227:Dmel_CG42701
uniprot id: Q24278
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Approximately 50-fold more sensitive to cGMP than to cAMP. May be involved in transduction cascades of both invertebrate photoreceptors and olfactory sensillae.
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
messages: Expressed in antennae and the visual system.
messages: Membrane

7227:Dmel CG33809
gene id: 7227:Dmel_CG33809
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG10262
gene id: 7227:Dmel_CG10262
uniprot id: Q9VIT0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Chromosome
messages: Cytoplasm
messages: Homotrimer (PubMed:17087725). Interacts with the catalytic subunits of two DNA polymerase complexes: PolD1 in the delta complex and PolE1/DNApol-epsilon255 in the epsilon complex (PubMed:17087725).
messages: Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility (PubMed:17087725). May function independently of PCNA during DNA repair (PubMed:17087725).
messages: Nucleus
messages: Ubiquitously expressed throughout development and in adults.

7227:Dmel CG15524
gene id: 7227:Dmel_CG15524
uniprot id: Q9VAC8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After pupae formation, expressed during centriole-to-cilium basal body conversion and in the early phase of ciliogenesis in neurons, then disappears (at protein level).
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:17412918, PubMed:17463247, PubMed:30013109). Required for centrosome biogenesis and duplication (PubMed:17412918, PubMed:17463247, PubMed:30013109, PubMed:33704067). In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function (PubMed:30013109). Required for sperm cilium basal body elongation together with Cep135 and Ana2 (PubMed:30013109).
messages: Expressed in spermatocyte and speratids (at protein level).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets (By similarity). Homodimer (PubMed:33704067). Interacts with Gorab (via C-terminus); binds as a homodimer to a Gorab monomer (PubMed:29892014, PubMed:33704067).
messages: Results in lack of centrioles and cilium formation, defects in coordination and reduced fertility (PubMed:30013109, PubMed:33704067). In neurons, RNAi-mediated knockdown after centriole assembly does not affect neuronal cilium basal body, cilia formation or movement coordination (PubMed:30013109). In spermatocytes, RNAi-mediated knockdown before centriole biogenesis results in reduced centriole numbers and fertility (PubMed:30013109). On the contrary RNAi-mediated knockdown after centriole biogenesis does not affect the number of centrioles, but affects maturation of a full-length cilium basal body and reduces fertility (PubMed:30013109).
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centriole
messages: centrosome
messages: cilium basal body

7227:Dmel CG12272
gene id: 7227:Dmel_CG12272
uniprot id: M9PCR4
uniprot id: Q9VUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458).
messages: Belongs to the strumpellin family.
messages: Component of the WASH complex.
messages: Early endosome

7227:Dmel CG3354
gene id: 7227:Dmel_CG3354
uniprot id: P16909
names: Developmental Stage
names: Function
messages: In pupae and in adults.
messages: Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.

7227:Dmel CG5742
gene id: 7227:Dmel_CG5742
uniprot id: A0A0B4KFB5
uniprot id: Q7K3G2
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32099
gene id: 7227:Dmel_CG32099
uniprot id: Q8SXB3
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

7227:Dmel CG4376
gene id: 7227:Dmel_CG4376
uniprot id: F0JAG6
uniprot id: M9MS06
uniprot id: M9PGA7
uniprot id: P18091
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the alpha-actinin family.
messages: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
messages: Homodimer; antiparallel. Interacts with Smn; the interaction occurs in adult thoracic tissues.
messages: Larval muscle isoform is expressed in the larval body wall, adult muscles of the head and abdomen and supercontractile muscles of the larva and adult. Adult muscle isoform accumulates within adult fibrillar and tubular muscles.
messages: Larval muscle isoform is found in the larvae and adults, the adult muscle isoform in adults only.
messages: Z line

7227:Dmel CG15433
gene id: 7227:Dmel_CG15433
uniprot id: Q9VQZ6
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Plays a role in the control of synaptic bouton expansion (PubMed:20626565). Required for larval development (PubMed:21288872).
messages: Component of the elongator complex.
messages: Pronounced larval developmental delay and death at the pupal stage with delayed and reduced ecdysone-induced transcription, developmental of melanotic nodules and up-regulation of stress-induced genes (PubMed:21288872). RNAi-mediated knockdown results in lethality at the late pupal stage (PubMed:20626565). RNAi-mediated knockdown in the central nervous system results in a hyperactive phenotype, sleep loss in adult females, a significant expansion in synaptic bouton number in the larval neuromuscular junction (NMJ), increased larval NMJ axonal length and branching, and misregulation of genes known to be involved in these processes with a marked increase in Hsc70-3 and Syb mRNA levels and a marked decrease in qvr/sss mRNA levels (PubMed:20626565). RNAi-mediated knockdown in hemocytes results in reduced hemocyte numbers and hemocyte aggregation (PubMed:21288872).
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7227:Dmel CG5193
gene id: 7227:Dmel_CG5193
uniprot id: M9PCM4
uniprot id: P29052
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIB family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.
messages: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus

7227:Dmel CG1489
gene id: 7227:Dmel_CG1489
uniprot id: O18413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with Rpn6 (PubMed:22187461). Interacts with imd and Usp2 isoform A (PubMed:25027767).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

7227:Dmel CG10706
gene id: 7227:Dmel_CG10706
uniprot id: M9PDT6
uniprot id: M9PGG9
uniprot id: M9PH41
uniprot id: Q7KVW5
uniprot id: X2JAI8
uniprot id: X2JDR8
uniprot id: X2JE69
uniprot id: X2JIE0
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel KCNN family. SK subfamily.
messages: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
messages: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
messages: Intron retention.
messages: Membrane
messages: Partially edited. Target of Adar.

7227:Dmel CG14208
gene id: 7227:Dmel_CG14208
uniprot id: A0A023GQ84
uniprot id: Q8IQW4
uniprot id: X2JL95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG32433
gene id: 7227:Dmel_CG32433
uniprot id: Q8IPU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr77a subfamily.
messages: Cell membrane
messages: In larvae, is expressed in dorsal pharyngeal sense organ.
messages: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.

7227:Dmel CG5853
gene id: 7227:Dmel_CG5853
uniprot id: Q9VL61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7227:Dmel CG11314
gene id: 7227:Dmel_CG11314
uniprot id: Q9VA42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

7227:Dmel CG10428
gene id: 7227:Dmel_CG10428
uniprot id: Q9VJ34
names: Similarity
messages: Belongs to the GSTCD family.

7227:Dmel CG11486
gene id: 7227:Dmel_CG11486
uniprot id: A8JNJ2
uniprot id: Q7KV83
uniprot id: Q8IRE7
uniprot id: Q95RR8
uniprot id: Q9I7T8
uniprot id: Q9VZV3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro (PubMed:23932717). The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs (By similarity).
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex (PubMed:23932717). Interacts with the GW182 family protein gw (PubMed:21981923, PubMed:23172285). Interacts with Gyf (PubMed:31114929).
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

7227:Dmel CG42303
gene id: 7227:Dmel_CG42303
uniprot id: B7Z0I7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snurportin family.
messages: Cajal body
messages: Cytoplasm
messages: Expressed throughout development and in adults, with highest levels of expression during embryogenesis.
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Interacts with components of the snRNP complex including SmB and Smn; these interactions are RNA-dependent. Interacts with importin-7 msk but not with importin subunit beta Fs(2)Ket; the interaction is RNA-dependent.
messages: Nucleus
messages: Nucleus speckle

7227:Dmel CG6730
gene id: 7227:Dmel_CG6730
uniprot id: Q9VLZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG5432
gene id: 7227:Dmel_CG5432
uniprot id: Q9VBF5
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

7227:Dmel CG2945
gene id: 7227:Dmel_CG2945
uniprot id: P39205
names: Developmental Stage
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: Detected primarily in the epidermal cells of the segmental grooves during germ-band retraction (7-9 hours after egg laying).
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

7227:Dmel CG3975
gene id: 7227:Dmel_CG3975
uniprot id: Q9Y118
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory component of the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity). As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (PubMed:22532806, PubMed:25826374, PubMed:31100062). Required to recruit the DNA polymerase delta complex to the nucleus of rapidly dividing embryonic cells, and as a consequence is essential for genome replication during the earliest cell cycles (PubMed:31100062, PubMed:25826374). Increases the efficiency and processivity of DNA synthesis of the DNA polymerases during mitotic DNA replication and repair (PubMed:22532806, PubMed:25826374, PubMed:31100062). During development this function is essential for preventing replication stress that results in the formation of chromosomal fragile sites (CFS) such as chromosomal breaks (PubMed:31100062, PubMed:25826374). Ensures genomic stability by promoting several types of DNA repair mechanisms including repairing broken dicentric chromosomes through homolog-dependent break-induced replication (BIR) (PubMed:22532806, PubMed:25826374, PubMed:31053594). During homologous recombination (HR) repair, required for maintaining the processivity of the delta complex during break-induced replication; a form of HR that requires extensive DNA synthesis such as the repair of large gaps (PubMed:25826374, PubMed:22532806). Able to suppress position effect variegation and may therefore have a role in the induction of chromatin state changes that likely include its activities in DNA replication and repair (PubMed:25826374).
messages: Component of both the DNA polymerase delta and DNA polymerase zeta complexes (By similarity). The DNA polymerase delta complex consists of three subunits: the catalytic subunit PolD1 and two accessory subunits PolD2/Pol31 and PolD3/Pol32 (PubMed:31100062). Within the delta complex, interacts with both PolD1 and PolD2 (PubMed:31100062). Component of the DNA polymerase zeta complex consisting of four subunits: the catalytic subunit PolZ1 and three accessory subunits PolZ2/Rev7, PolD2/Pol31 and PolD3/Pol32 (By similarity).
messages: Expressed in adult females and embryos (at the protein level).
messages: Expressed in ovaries (at the protein level) (PubMed:31100062). Expressed in ovaries (PubMed:25826374).
messages: Nucleus
messages: Oocytes and embryos lacking maternal PolD3, show no nuclear localization of the delta complex members PolD1 and PolD2, resulting in limited genome replication during the earliest cell cycles and thus early developmental arrest (PubMed:31100062). Mutants, presumably with maternal but not zygotic PolD3, develop normally however adults display a variable degree of bristle loss or shortening, and females are sterile while males are fertile (PubMed:31100062). In larval salivary glands, the delta complex localizes normally to the nuclei and chromosomes display a significant decrease in homologous recombination repair (PubMed:31100062). Chromosomes also exhibit spontaneous double strand breaks that primarily result from defects in genomic replication and, to a lesser extent, in DNA repair synthesis (PubMed:31100062).
messages: nucleoplasm

7227:Dmel CG1193
gene id: 7227:Dmel_CG1193
uniprot id: E1JJ62
uniprot id: Q4QPP5
uniprot id: Q961H1
uniprot id: Q9VNI0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: centrosome
messages: spindle
messages: spindle pole

7227:Dmel CG10588
gene id: 7227:Dmel_CG10588
uniprot id: Q9VP94
names: Similarity
messages: Belongs to the peptidase M16 family.

7227:Dmel CG5648
gene id: 7227:Dmel_CG5648
uniprot id: Q9VK14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG5695
gene id: 7227:Dmel_CG5695
uniprot id: A0A0B4KGX1
uniprot id: A0A0B4LHV4
uniprot id: H1UUJ8
uniprot id: Q01989
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Isoform B is expressed both maternally and zygotically throughout development with highest level during mid-embryogenesis and adulthood. At these zygotic stages isoform D is also expressed.
messages: Isoform B is present at a higher level in the head and gonads than in the thoraxes. Isoform 145 kDa is found only in the head. CLIP-190 and jar are coexpressed at several times in development and in a number of tissues, including embryonic axonal neuron processes and posterior pole.
messages: Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle.
messages: cytoskeleton

7227:Dmel CG8938
gene id: 7227:Dmel_CG8938
uniprot id: P41043
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).
messages: Expressed throughout development with highest levels being observed in nonfeeding stages, i.e. during embryonic and pupal development.
messages: Homodimer.

7227:Dmel CG33896
gene id: 7227:Dmel_CG33896
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG1158
gene id: 7227:Dmel_CG1158
uniprot id: Q9VNA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50. The complex interacts with the Tim44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

7227:Dmel CG46338
gene id: 7227:Dmel_CG46338
uniprot id: Q7K4V4
names: Caution
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.

7227:Dmel CG3921
gene id: 7227:Dmel_CG3921
uniprot id: M9NDE3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Embryonic lethality. Mutant embryos establish functional septate junctions but, due to rudimentary septae formation during subsequent embryonic development, these become non-functional (PubMed:25704509). Abnormal liquid clearance of tracheal tubes (PubMed:25704509). Convoluted and elongated tracheal branches (PubMed:25704509, PubMed:25982676). During late embryogenesis, mislocalization of septate junction core components pck/mega, kune, Nrx-IV and Nrg and impaired cell adhesion at the lateral cell membrane (PubMed:25704509). Mislocalization of Fas3 in the epithelia of mutant embryos and loss of accumulation of Gli at tricellular junctions (PubMed:25982676).
messages: Expression detected in embryonic epithelia and central nervous system (at protein level) (PubMed:25982676). First detected during stage 13 in the tracheal system, the foregut, the hindgut, the salivary glands and the epidermis (PubMed:25704509, PubMed:25982676). Expression persists in these tissues until the end of embryogenesis (PubMed:25704509). Expression in epithelia declines from late stage 15 and expression appears in the central nervous system during stage 16 (PubMed:25982676).
messages: May be proteolytically cleaved in the extracellular domain.
messages: N-glycosylated.
messages: Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation (PubMed:25704509). Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis (PubMed:25704509). Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions (PubMed:25982676). Required for the accumulation of Gli at tricellular junctions.
messages: The name 'bark beetle' derives from the convoluted tracheal branches seen in mutant embryos which resemble the tracks of bark beetle larvae (PubMed:25704509). The name 'anakonda' is also based on the convoluted tracheal tube phenotype of mutant embryos (PubMed:25982676).
messages: adherens junction
messages: septate junction
messages: tight junction

7227:Dmel CG8411
gene id: 7227:Dmel_CG8411
uniprot id: Q01820
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Oogenesis and embryogenesis.
messages: Required for the specification of pole cells and germ cell formation. Mothers with reduced glc function give rise to sterile adult progeny that lack germ cells.

7227:Dmel CG4922
gene id: 7227:Dmel_CG4922
uniprot id: P21750
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in temporally and spatially restricted patterns during embryogenesis in the anterior, ventral and terminal regions of the embryo.
messages: Likely to be involved in the establishment of the head.
messages: Secreted

7227:Dmel CG9779
gene id: 7227:Dmel_CG9779
uniprot id: Q9VN02
names: Similarity
messages: Belongs to the SNF7 family.

7227:Dmel CG33276
gene id: 7227:Dmel_CG33276
uniprot id: Q7KU86
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (By similarity). The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U (By similarity). Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1 (PubMed:26715182, PubMed:28953965). The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates (By similarity). Plays a role in the regulation of JNK signaling in response to oxidative stress (PubMed:26715182).
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
messages: Cytoplasm
messages: Interacts with cer.
messages: Lethal; most flies die by the pupal stages (PubMed:26715182). Escapers are small, less active, display a significantly reduced fecundity, shortened lifespan, increased resistance to oxidative stress, up-regulation of the JNK signaling pathway and increased expression of Jafrac1 and GstD1 (PubMed:26715182). Simultaneous knockout of Jafrac1 restores normal sensitivity to oxidative stress (PubMed:26715182). RNAi-mediated knockdown leads to higher tolerance to oxidative stress (PubMed:26715182).
messages: Ubiquitously expressed during all embryonic stages, third instar larval imaginal disk, early pupal stages and in the adult (at protein level).

7227:Dmel CG43398
gene id: 7227:Dmel_CG43398
uniprot id: Q7KRY7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LAP (LRR and PDZ) protein family.
messages: Cell membrane
messages: Cytoplasm
messages: During germ band extension, expression of isoform A occurs predominantly in neuroblasts derived from the neuro-ectoderm and later is restricted to CNS neurons and pole cells. Isoform C is strongly expressed in PNS and a subset of CNS neurons. In the adult, expressed in third antennal segment and maxillary palps, major olfactory organs and in Johnstons organ in the second antennal segment. Expression is also observed in cortical regions of the brain. Isoforms expressed in epithelia are coexpressed with dlg1 throughout development.
messages: Expressed both zygotically and maternally in embryos. Isoform A and isoform C have high expression throughout embryonic development and very low expression in later developmental stages. In adults, isoform A is a male-specific isoform and isoform C a female specific.
messages: Flies exhibit aberrant cell shape and loss of the monolayer organization of embryonic epithelia creating a corrugated cuticular surface that is riddled with holes hence the gene name scribble. Misdistribution of apical proteins and adherens junctions to the basolateral cell surface is also exhibited.
messages: Probable cloning artifact.
messages: Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.
messages: tight junction

7227:Dmel CG4167
gene id: 7227:Dmel_CG4167
uniprot id: P05812
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG42575
gene id: 7227:Dmel_CG42575
uniprot id: Q9VTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

7227:Dmel CG12343
gene id: 7227:Dmel_CG12343
uniprot id: Q9V5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

7227:Dmel CG2982
gene id: 7227:Dmel_CG2982
uniprot id: E2QD64
uniprot id: Q7K4H4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.

7227:Dmel CG2614
gene id: 7227:Dmel_CG2614
uniprot id: Q9VIK9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus.

7227:Dmel CG10296
gene id: 7227:Dmel_CG10296
uniprot id: Q9VI12
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG32344
gene id: 7227:Dmel_CG32344
uniprot id: Q8SY39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

7227:Dmel CG17652
gene id: 7227:Dmel_CG17652
uniprot id: Q9VQ40
names: Subcellular Location Annotation
messages: nucleolus

7227:Dmel CG7297
gene id: 7227:Dmel_CG7297
uniprot id: Q9VUT6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers both EA2 and the diglycosylated Muc5AC-3/13 as substrates, albeit at very low levels fro Muc5AC-3/13.
messages: Expressed both maternally and zygotically. Weakly expressed during early embryonic stages but increases during 12-24 hours of embryogenesis through larval development and continues to be expressed throughout adulthood, albeit at slightly lower levels in males than females.
messages: Expressed in developing oocytes and egg chambers. During embryonic stages 9-11, expressed in the primordium of the foregut, midgut and hindgut. During embryonic stages 12-13, expressed in the posterior midgut and hindgut. During embryonic stages 14-15, expression continues in the hindgut. No expression detected during embryonic stages 16-17 or in third instar larvae imaginal disks.
messages: Golgi apparatus membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG3752
gene id: 7227:Dmel_CG3752
uniprot id: Q9VLC5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7227:Dmel CG15153
gene id: 7227:Dmel_CG15153
uniprot id: Q9VJA6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG42373
gene id: 7227:Dmel_CG42373
uniprot id: B7Z018
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

7227:Dmel CG15438
gene id: 7227:Dmel_CG15438
uniprot id: Q9VQZ7
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG31272
gene id: 7227:Dmel_CG31272
uniprot id: Q9VGX6
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG32703
gene id: 7227:Dmel_CG32703
uniprot id: Q9W354
names: Function
names: Induction
names: Similarity
messages: Amino-acid starvation stabilizes protein level (PubMed:21847093). Up-regulated upon impaired ribosome biogenesis and starvation (PubMed:25393288).
messages: Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner (PubMed:21847093, PubMed:25393288). In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly (PubMed:21847093). Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53 (PubMed:25393288).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

7227:Dmel CG7741
gene id: 7227:Dmel_CG7741
uniprot id: A0A0B4K6X7
uniprot id: A1Z8J0
uniprot id: E8NH71
names: Similarity
messages: Belongs to the CWF19 family.

7227:Dmel CG14939
gene id: 7227:Dmel_CG14939
uniprot id: Q9VKF0
names: Similarity
messages: Belongs to the cyclin family.

7227:Dmel CG34083
gene id: 7227:Dmel_CG34083
uniprot id: B6E0R2
uniprot id: P18932
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG10340
gene id: 7227:Dmel_CG10340
uniprot id: Q9VES8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

7227:Dmel CG1957
gene id: 7227:Dmel_CG1957
uniprot id: Q9V3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160. Interacts with Sym and Cpsf73 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.
messages: Nucleus

7227:Dmel CG31004
gene id: 7227:Dmel_CG31004
uniprot id: A0A0B4LHZ4
uniprot id: Q0KHY3
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apicolateral cell membrane
messages: At embryonic stage 12, expressed in endoderm-derived tissues (at protein level) (PubMed:22854041). In late-stage embryos, third-instar larvae and adult flies, expressed in the midgut, outer epithelial layer of the proventriculus and Malpighian tubules, but not expressed in the foregut and hindgut (at protein level) (PubMed:22854041, PubMed:26848177).
messages: Expressed throughout embryonic, larval and adult stages (at protein level).
messages: Forms a complex with Ssk and Tsp2A (PubMed:26848177). Interacts with Ssk; the interaction may be necessary for the localization of both proteins to the cell apicolateral region (PubMed:22854041).
messages: Homozygous larval lethal. Mutant embryos hatch into the first instar larvae, but die within 1 day. In mutant larvae midgut, a few septa are present at the cell contacts but large gaps between the lateral membranes of adjacent epithelial cells are frequently observed. Mutant larvae lack the three-layered structure of the proventriculus.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction (PubMed:22854041, PubMed:26848177). Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium (PubMed:22854041). Required for maintaining the three-layered structure of the proventriculus (PubMed:22854041).
messages: septate junction

7227:Dmel CG9286
gene id: 7227:Dmel_CG9286
uniprot id: Q9VFR0
names: Similarity
messages: Belongs to the BCP1 family.

7227:Dmel CG18525
gene id: 7227:Dmel_CG18525
uniprot id: Q9VFC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Expressed both maternally and zygotically. Expressed throughout development, with very weak expression between stages 10-16 of embryogenesis and weak expression in adults. In stage 5-6 blastoderm and gastrulating embryos, expression is uniform. In stage 16-17 embryos, expressed in the ventral and dorsal epidermis, posterior spiracles, foregut, hindgut, sensory nervous system primordium, pharynx and respiratory system. In larvae, expressed in the posterior spiracles and tracheal system. In pupae, expressed in the wing imaginal disks.
messages: Expressed in nurse cells and oocytes. Expressed in wings.
messages: Larval lethal (PubMed:19581577). Larvae develop melanotic spots and display an increase in the activity of the activated form of prophenoloxidase 1 (PPO1), phenoloxidase (PO) (PubMed:19581577). Larvae display enhanced activation of the Toll signaling pathway, with increased Tl, spz and Drs expression (PubMed:19581577). RNAi-mediated knockdown of maternal and zygotic expression results in adults that have a reduced lifespan (PubMed:19581577). Wing development appears to be unaffected, however after emergence from the pupal case adult wings fail to unfold and instead remain folded and hypotrophic until death (PubMed:18956323). Other aspects of development in embryos, larvae, pupae and adults appears to be unaffected.
messages: Secreted
messages: Serine protease inhibitor with activity toward trypsin (PubMed:18956323). Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin (PubMed:19581577). Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade (PubMed:19581577). Essential for unfolding and expansion of the wings after emergence from the pupal case (PubMed:18956323). May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz (PubMed:19581577).

7227:Dmel CG9393
gene id: 7227:Dmel_CG9393
uniprot id: A0A0B4KGL6
uniprot id: Q9VHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the metaxin family.
messages: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane

7227:Dmel CG5342
gene id: 7227:Dmel_CG5342
uniprot id: Q9VGL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG10972
gene id: 7227:Dmel_CG10972
uniprot id: Q9W250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

7227:Dmel CG10278
gene id: 7227:Dmel_CG10278
uniprot id: A0A0B4JDD2
uniprot id: Q9VF00
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG5989
gene id: 7227:Dmel_CG5989
uniprot id: M9PEJ9
uniprot id: M9PF10
uniprot id: Q9VSM4
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG6154
gene id: 7227:Dmel_CG6154
uniprot id: Q9VBG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7227:Dmel CG2707
gene id: 7227:Dmel_CG2707
uniprot id: P25028
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell cycle-dependent nuclear envelope component required for embryonic mitosis.
messages: Cytoplasm
messages: Maternal protein synthesized during postoogenic maturation and persisting throughout embryogenesis.
messages: Nucleus envelope
messages: The OPA repeat-containing and the Ser/Thr-rich regions might be involved in protein-protein interactions with the major protein-rich layer of the nuclear envelope.
messages: nucleoplasm

7227:Dmel CG5227
gene id: 7227:Dmel_CG5227
uniprot id: O97394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sidekick family.
messages: Membrane
messages: Participates in homotypic or heterotypic interactions in the eye during pattern formation to prevent extra cells from joining the precluster and differentiating as photoreceptor cells.

7227:Dmel CG10975
gene id: 7227:Dmel_CG10975
uniprot id: P16620
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
messages: Membrane
messages: Possible cell adhesion receptor.

7227:Dmel CG9097
gene id: 7227:Dmel_CG9097
uniprot id: M9PDT5
uniprot id: M9PE50
uniprot id: M9PGP8
uniprot id: Q9W0K7
names: Caution
names: Function
names: Miscellaneous
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
messages: A paper showing that the protein forms homodimers via the BTB domain has been retracted by the authors, due to concerns regarding the validity of their data. However, they still consider that their main conclusions may be correct and require further testing.
messages: Leg imaginal disk at the central region of the tarsus and in eye antenna disk at the basal cylinder.
messages: Nucleus
messages: Probable cloning artifact.
messages: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.

7227:Dmel CG15441
gene id: 7227:Dmel_CG15441
uniprot id: Q94529
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation.

7227:Dmel CG32227
gene id: 7227:Dmel_CG32227
uniprot id: Q9VWA7
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5540
gene id: 7227:Dmel_CG5540
uniprot id: Q9VAZ3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG12014
gene id: 7227:Dmel_CG12014
uniprot id: Q9VZP8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7227:Dmel CG1098
gene id: 7227:Dmel_CG1098
uniprot id: Q9Y0Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cell cortex

7227:Dmel CG1424
gene id: 7227:Dmel_CG1424
uniprot id: O01939
uniprot id: X2JG23
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Misato' means 'beautiful dawn' in Japanese.
messages: Belongs to the misato family.
messages: Irregular chromosome segregation during mitosis leading to death before the third instar larval stage. Larvae show abnormalities such as absence of imaginal disk tissue, and reduction in brain size.
messages: Mitochondrion

7227:Dmel CG3483
gene id: 7227:Dmel_CG3483
uniprot id: Q9W172
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

7227:Dmel CG9916
gene id: 7227:Dmel_CG9916
uniprot id: A8E774
uniprot id: P25007
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7227:Dmel CG6492
gene id: 7227:Dmel_CG6492
uniprot id: Q9VX14
uniprot id: X2JL00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG5657
gene id: 7227:Dmel_CG5657
uniprot id: Q9VG77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

7227:Dmel CG8566
gene id: 7227:Dmel_CG8566
uniprot id: A0A0B4K767
uniprot id: A0A0B4K7D4
uniprot id: A0A0B4KF91
uniprot id: A0A126GUN3
uniprot id: A1ZAJ2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
messages: Expressed in muscles.
messages: Flies prevent nerve endings from transforming to synaptic boutons: growth cones become constricted but remain within contact fields as thin processes that lack varicosities or boutons. Mutant embryos die at late stage, they are paralyzed and lacked the coordinated muscle peristalsis required for hatching.
messages: Monomer (By similarity). Interacts with Arl8 (PubMed:30174114).
messages: Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.
messages: axon
messages: cytoskeleton

7227:Dmel CG8601
gene id: 7227:Dmel_CG8601
uniprot id: A0A023GPN3
uniprot id: Q9VS48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Forms a heterodimer with SLX1. Interacts with mei-9; catalytic subunit of the MEI-9-ERCC1 endonuclease.
messages: Nucleus
messages: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity). Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers.

7227:Dmel CG14666
gene id: 7227:Dmel_CG14666
uniprot id: Q9VN97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50. The complex interacts with the Tim44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

7227:Dmel CG9938
gene id: 7227:Dmel_CG9938
uniprot id: Q9VYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

7227:Dmel CG17921
gene id: 7227:Dmel_CG17921
uniprot id: Q06943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Nucleus

7227:Dmel CG6480
gene id: 7227:Dmel_CG6480
uniprot id: Q9VWA8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: Cytoplasm
messages: Increased trimethylation of 'Lys-20' of histone H4.
messages: May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits (By similarity). May be involved in epigenetic regulation of muscle differentiation through regulation of the activity of the histone-lysine N-methyltransferase Suv4-20.
messages: Z line
messages: nucleolus

7227:Dmel CG10812
gene id: 7227:Dmel_CG10812
uniprot id: Q9VZR2
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG10197
gene id: 7227:Dmel_CG10197
uniprot id: A0A0B4KFQ1
uniprot id: A1Z9V2
uniprot id: A8DYD9
uniprot id: E2QCN0
uniprot id: P56721
uniprot id: V5LWW0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the COE family.
messages: Isoform COL1 is expressed from 3 hours of embryogenesis, with a peak of accumulation between 8 and 16 hours post-fertilization. Expression persists at very low level in first instar larvae and accumulates again in third instar larvae and pupae. Isoform COL2 is expressed after 8 hours of embryogenesis, peaks in first instar larvae and is present at low levels in third instar larvae and pupae.
messages: Its expression at the blastoderm stage is restricted to a single stripe of cells corresponding to part of the intercalary and mandibular segment primordia, possibly parasegment O.
messages: May act as a 'second-level regulator' of head patterning. Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment. Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment. Required at the onset of the gastrulation for the correct formation of the mandibular segment.
messages: Nucleus

7227:Dmel CG10986
gene id: 7227:Dmel_CG10986
uniprot id: M9PHJ5
uniprot id: M9PJM7
uniprot id: P54362
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large chains (delta and beta3), a medium chain (mu3) and a small chain (sigma3).
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Intron retention. This sequence is incomplete at 5'- and 3'-ends and extensively differs from that shown at positions 1-269, 546 and 840-1034.
messages: May be a coat protein involved in the formation of specialized structures like pigment granules.
messages: Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity).
messages: clathrin-coated vesicle membrane

7227:Dmel CG31195
gene id: 7227:Dmel_CG31195
uniprot id: Q8IN49
names: Subcellular Location Annotation
messages: Cell membrane

7227:Dmel CG9279
gene id: 7227:Dmel_CG9279
uniprot id: Q7JQV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cytoskeleton

7227:Dmel CG4181
gene id: 7227:Dmel_CG4181
uniprot id: Q9VG98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).
messages: Homodimer.

7227:Dmel CG6050
gene id: 7227:Dmel_CG6050
uniprot id: A1Z9E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7227:Dmel CG5877
gene id: 7227:Dmel_CG5877
uniprot id: Q8IR40
uniprot id: Q9VXW9
names: Similarity
messages: Belongs to the NRDE2 family.

7227:Dmel CG14022
gene id: 7227:Dmel_CG14022
uniprot id: Q9VMR9
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG11084
gene id: 7227:Dmel_CG11084
uniprot id: A1Z6W3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Expressed both maternally and zygotically. Isoform B is expressed in embryos only. Isoform A and isoform C are expressed in embryos and pupae.
messages: Expressed in the wing, leg and eye imaginal disks. Expressed within the photoreceptors of the eye.
messages: Flies exhibit aberrant hair and bristle orientation on the wings and aberrant ommatidial arrangement in the compound eye.
messages: Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.

7227:Dmel CG11325
gene id: 7227:Dmel_CG11325
uniprot id: Q7KTL9
uniprot id: Q9VM96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7227:Dmel CG9884
gene id: 7227:Dmel_CG9884
uniprot id: A4V013
uniprot id: Q9NLA6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the OAF family.
messages: Embryonic expression is in small clusters of cells along posterior margin of most segments, brain and segmentally repeating pattern along midline of nerve cord. Expressed in embryonic, larval and adult gonads of both sexes, and larval imaginal disks.
messages: Expressed both maternally and zygotically throughout development with highest levels in pupae and adults.
messages: Readthrough of the terminator UGA may occur between the codons for 332-Glu and 334-Arg.
messages: Vital for proper neuronal development and hatching.

7227:Dmel CG12085
gene id: 7227:Dmel_CG12085
uniprot id: A4V193
uniprot id: Q8T6B9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM half pint family.
messages: Expressed in all germline cells and within the follicle cell.
messages: Interacts with enc. However, given the cytoplasmic localization of enc, the relevance of such interaction is unclear.
messages: Nucleus
messages: Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq.
messages: The third RNA recognition motif, called PUMP domain in PubMed:10606266, is atypical and may rather mediate protein-protein interactions.

7227:Dmel CG2248
gene id: 7227:Dmel_CG2248
uniprot id: P40792
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Detected in oocyte border cells (BC), with increased expression at the front of the BC cluster.
messages: During various developmental processes, regulates changes in cell morphology in response to extracellular signals (PubMed:7958857, PubMed:10323867, PubMed:24855950). During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 signaling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directionally persistent migration (PubMed:24855950). Involved in axon outgrowth and myoblast fusion (PubMed:7958857). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867). Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes (PubMed:22547074).
messages: Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus). When GTP-bound, interacts with Pak (PubMed:8628256).

7227:Dmel CG10866
gene id: 7227:Dmel_CG10866
uniprot id: Q9VZK9
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG7070
gene id: 7227:Dmel_CG7070
uniprot id: O62619
names: Developmental Stage
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.
messages: In adults expressed predominantly in the thorax.
messages: Low levels in larvae and pupae, but increases in young adults, becoming relatively stable in two-day-old flies.

7227:Dmel CG4464
gene id: 7227:Dmel_CG4464
uniprot id: E2QD65
uniprot id: P39018
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

7227:Dmel CG3265
gene id: 7227:Dmel_CG3265
uniprot id: A1Z6P3
uniprot id: Q7JZD3
uniprot id: Q9XZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

7227:Dmel CG12181
gene id: 7227:Dmel_CG12181
uniprot id: Q00725
names: Polymorphism
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Salivary gland.
messages: Secreted
messages: The sequence shown is that from strain Oregon-R. The number of the 7 residues repeat vary between strains: strain Oregon-R(2/10) has 11 more copies, strain Karsnas has 8 more copies of the repeat, strain Samarkand-pk1 has 1 less copy and strain Samarkand-pSW9 and strain Berkeley have 2 less copies.

7227:Dmel CG5830
gene id: 7227:Dmel_CG5830
uniprot id: M9PFN0
names: Activity Regulation
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Expressed ubiquitously throughout embryonic development (at protein level).
messages: Monomer (PubMed:31491385). Forms higher-order protein aggregates with amyloid-like features during gastrulation (PubMed:31491385). Interacts with babo, dah, Irk1, pch2, Ras64B, sax and Src64B (PubMed:31491385).
messages: Phosphatase activity requires amyloid-like aggregation on the membrane.
messages: Prion-like membrane-associated phosphatase (PubMed:31491385). Phosphatase activity depends on amyloid-like assembly at the membrane (PubMed:31491385). Might have a role in establishment of segment polarity in embryos (PubMed:31491385).

7227:Dmel CG1245
gene id: 7227:Dmel_CG1245
uniprot id: Q9VNG0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene.
messages: Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Maternally encoded. Expression decreases during larval stages then rises during mid-pupal metamorphosis.
messages: Nucleus

7227:Dmel CG9107
gene id: 7227:Dmel_CG9107
uniprot id: Q9VMJ1
names: Similarity
messages: Belongs to the RRP7 family.

7227:Dmel CG11276
gene id: 7227:Dmel_CG11276
uniprot id: P41042
uniprot id: X2JGM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

7227:Dmel CG33826
gene id: 7227:Dmel_CG33826
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG17565
gene id: 7227:Dmel_CG17565
uniprot id: Q9VEV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

7227:Dmel CG18250
gene id: 7227:Dmel_CG18250
uniprot id: A0A0C4DHF6
uniprot id: A1ZA89
uniprot id: Q8STB9
uniprot id: Q8WR08
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

7227:Dmel CG42328
gene id: 7227:Dmel_CG42328
uniprot id: O77086
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Guanine nucleotide-releasing protein that binds to SH3 domain of Crk. Transduces signals from Crk to activate RAS. Also involved in MAPK activation.
messages: Throughout development.
messages: Ubiquitous.

7227:Dmel CG3634
gene id: 7227:Dmel_CG3634
uniprot id: M9PFT2
uniprot id: Q9VPB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

7227:Dmel CG5802
gene id: 7227:Dmel_CG5802
uniprot id: Q9VDD7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: Probable sugar transporter.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

7227:Dmel CG31690
gene id: 7227:Dmel_CG31690
uniprot id: Q9VQE9
uniprot id: T2GG64
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Probable cloning artifact giving rise to incorrect N-terminus.
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

7227:Dmel CG17331
gene id: 7227:Dmel_CG17331
uniprot id: Q9VJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

7227:Dmel CG8694
gene id: 7227:Dmel_CG8694
uniprot id: P07191
names: Developmental Stage
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.

7227:Dmel CG31783
gene id: 7227:Dmel_CG31783
uniprot id: M9MRL5
uniprot id: Q8INY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG11822
gene id: 7227:Dmel_CG11822
uniprot id: Q9VPQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG31866
gene id: 7227:Dmel_CG31866
uniprot id: Q8IPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TADA1 family.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

7227:Dmel CG8781
gene id: 7227:Dmel_CG8781
uniprot id: F2FB57
uniprot id: Q9V535
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Tsunagi' means 'connection' or 'link' in Japanese.
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839).
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Developing photoreceptor cell clusters express reduced levels of rolled/MAPK and fail to differentiate normally.
messages: Expressed throughout development. Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis.
messages: Heterodimer (via RRM domain) with mago (PubMed:11691839, PubMed:12730685, PubMed:12704080). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N-terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490).
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle
messages: The RNA recognition motif (RRM) is involved in the interaction with mago. The RNA-binding activity of such domains is therefore uncertain.

7227:Dmel CG8279
gene id: 7227:Dmel_CG8279
uniprot id: A0A0B4KFZ3
uniprot id: A0A0B4LH87
uniprot id: Q9VFI9
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Expressed in Malpighian tubule principal cells (PubMed:16232123, PubMed:15673286). Also expressed in adult head (PubMed:15673286).
messages: Flies display increased active transport of cGMP. Overexpression of Pde6 confers inhibition of the active transport and efflux of cGMP by tubules.
messages: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123).
messages: Inhibited by sildenafil and zaprinast.
messages: Interacts with PrBP.

7227:Dmel CG10711
gene id: 7227:Dmel_CG10711
uniprot id: Q9VU87
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:19132102). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:19132102). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA (PubMed:17268469). This interaction is required for the anterior localization of bicoid mRNA in the developing egg (PubMed:17268469). Plays a role in promoting mitochondrial autophagy (mitophagy) (PubMed:29307555).
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Localizes to the anterior cortex of the oocyte in the same region as bicoid mRNA from stage 10B/11 of oogenesis.
messages: Multivesicular body sorting defects, with large amounts of ubiquitinated proteins detected on endosomes (PubMed:19132102). Bicoid mRNA is mislocalized in developing eggs (PubMed:17268469).
messages: The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to the 3' UTR of bicoid mRNA.
messages: Ubiquitously expressed in the ovary.

7227:Dmel CG7480
gene id: 7227:Dmel_CG7480
uniprot id: F5XVG5
uniprot id: Q8MVS5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Expressed at high level in ovaries. Expressed at low level in testis. Expressed at higher level in adult females than males. During oogenesis, it is detected in germ cells and follicle epithelia of all developmental stages. Initially expressed during early stages of oogenesis in region I and reaches high levels in regions IIa and IIb of the germarium. Highly expressed in stage 2 egg chambers. Remains highly expressed during later stages of oogenesis. During embryonic stages 9-11, expressed in the primordium of the foregut, midgut and hindgut. Expressed in salivary glands from embryonic stage 12 onwards. During embryonic stages 12-13, expressed in the posterior midgut and hindgut. During embryonic stages 14-15, expression continues in the hindgut. During embryonic stages 16-17, expressed in the dorsal longitudinal trachea and posterior spiracles. In third instar larvae, ubiquitously expressed in wing, eye-antennal, leg and haltere imaginal disks.
messages: Expressed both maternally and zygotically. Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development.
messages: Golgi apparatus membrane
messages: Membrane
messages: Mutant larval shows down-regulation of synaptic O-linked glycosylation, integrin level and signaling via Ten-m and if. Synapses show smaller synaptic boutons, expanded activity-dependent postsynaptic pockets which affect synaptic plasticity and synaptic strength in both the pre-synaptic and post-synaptic assembly, no differences in neuromuscular junction morphology (PubMed:25253852). Simultaneous knockout of Pgant3, restores normal synaptic strength (PubMed:25253852). RNAi-mediated knockdown is lethal (PubMed:22157008). RNAi-mediated knockdown in the mesoderm, respiratory system, digestive system or reproductive tract results in a reduction in viability (PubMed:22157008).
messages: Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:11925450, PubMed:12829714). Displays the same enzyme activity toward MUC1, MUC4, and EA2 (PubMed:11925450, PubMed:12829714). Not involved in glycosylation of erythropoietin (EPO) (PubMed:11925450). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:11925450, PubMed:12829714). Protein modification by this enzyme might be important for cytokinesis and tube formation during embryogenesis (PubMed:16251381, PubMed:20807760). Together with Pgant3, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles (PubMed:25253852).
messages: The human ortholog GALNT11 (AC Q8NCW6) is not able to rescue lethality caused by the SF32 mutation.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

7227:Dmel CG3940
gene id: 7227:Dmel_CG3940
uniprot id: Q9VH26
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG9156
gene id: 7227:Dmel_CG9156
uniprot id: B4F4X2
uniprot id: Q05547
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Interacts with Nop17l.

7227:Dmel CG17917
gene id: 7227:Dmel_CG17917
uniprot id: Q9I7L3
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

7227:Dmel CG6300
gene id: 7227:Dmel_CG6300
uniprot id: Q9VDU4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7227:Dmel CG9245
gene id: 7227:Dmel_CG9245
uniprot id: Q8SX37
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although Mn(2+) can act as a cofactor, it is much less effective than Mg(2+).
messages: Apical cell membrane
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction (PubMed:17151285, PubMed:24828534, PubMed:24603715). May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing an essential role during phospholipase C-mediated transduction (PubMed:17151285). This function is essential in photoreceptors for light-activated recycling of PtdInsP2 during phototransduction (PubMed:17151285). As a key enzyme of the phosphoinositide pathway, indirectly involved in the polarized secretion of basal membrane (BM) proteins in follicle epithelial (FE) cells through promoting PtdInsP2 synthesis in the apical and lateral plasma membranes of FE cells (PubMed:24828534). PtdInsP2 controls the localization of Crag and perhaps the localization and expression of strat, both of which are essential for restricting the secretion of BM proteins to the basal surface (PubMed:24828534, PubMed:28228250).
messages: Embryonic lethal (PubMed:17151285). In follicle cells, abnormal apical accumulation of the basal membrane (BM) proteins trol and vkg (PubMed:24828534). Decreased expression of strat in follicle epithelial cells (PubMed:28228250). RNAi-mediated knockdown in both larval salivary glands and fat body, results in small salivary glands that accumulate lipid droplets. This is likely due to the observed decrease in PtdIns levels that would lead to low insulin pathway activity and defective cell growth. RNAi-mediated knockdown in the fat body also results in a decrease in PtdIns levels in the fat body and a decrease in fat body size (PubMed:24603715).
messages: Expressed throughout development, with low levels of expression in embryos and 1st instar larvae, and highest levels of expression in adults (at protein level).
messages: In adults, expression is higher in the head than in the body (at protein level).
messages: Lateral cell membrane

7227:Dmel CG34405
gene id: 7227:Dmel_CG34405
uniprot id: A0A0B4K7I8
uniprot id: A0A0B4K814
uniprot id: A0A0B4K887
uniprot id: A0A0B4K8B5
uniprot id: A0A0B4KFH8
uniprot id: Q9W0Y8
names: Caution
names: Domain
names: Function
names: RNA Editing
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily.
messages: Cell membrane
messages: In embryonic and larval stages, expression is limited to very few non-neuronal cells in either the CNS or PNS. In pupal and adult stages, expressed in cell bodies of the fly central nervous system, including optic lobes, central brain, subesophageal ganglion, thoracico-abdominal ganglion, major olfactory organs, the third antennal segment and the maxillary palps.
messages: Intron retention.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Plays a role in processing of olfactory information during the olfactory avoidance response.
messages: Membrane
messages: Partially edited. Target of Adar.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

7227:Dmel CG6914
gene id: 7227:Dmel_CG6914
uniprot id: Q9VNT3
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

7227:Dmel CG9258
gene id: 7227:Dmel_CG9258
uniprot id: B5RIR1
uniprot id: Q24046
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage.
messages: In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it is concentrated in the thorax and abdomen (muscle tissue, digestive system and Malpighian tubules) and weakly expressed in the head. Expression is diffuse in the nervous system.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with nkain.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

7227:Dmel CG3986
gene id: 7227:Dmel_CG3986
uniprot id: Q9W2M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7227:Dmel CG11697
gene id: 7227:Dmel_CG11697
uniprot id: M9PH97
uniprot id: Q9VYX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG9538
gene id: 7227:Dmel_CG9538
uniprot id: Q9VY18
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG5105
gene id: 7227:Dmel_CG5105
uniprot id: Q9VPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

7227:Dmel CG4568
gene id: 7227:Dmel_CG4568
uniprot id: O18412
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Associated with mitochondria in spermatids during a narrow developmental window. Mitochondria align on the spindle equator throughout meiotic divisions, but it is not expressed on mitochondria until the last of meiosis II. In postmeiotic haploid spermatids, it is associated with aggregating mitochondria and highly expressed on onion stage Nebenkerns. Expressed at lower levels associated with early elongation stage mitochondrial derivatives. Not detected on more elongated mitochondria.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
messages: Defective mitochondrial fusion in spermatids results in onion-staged nebenkerns with irregular borders that contain many small mitochondria (PubMed:18799731). At the leaf-blade stage nebenkerns contain many small mitochondria instead of the two mitochondria derivatives seen in wild-type spermatids (PubMed:18799731).
messages: Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis (PubMed:9230308, PubMed:18799731). In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (PubMed:9230308, PubMed:18799731). Essential for fertility (PubMed:9230308).
messages: Mitochondrion outer membrane
messages: Specifically expressed in male germ cells, in spermatocytes and early spermatids. Not expressed in other tissues.

7227:Dmel CG6868
gene id: 7227:Dmel_CG6868
uniprot id: P25723
names: Cofactor
names: Function
names: Miscellaneous
messages: Binds 1 zinc ion per subunit.
messages: Mutations in TLD lead to a partial transformation of dorsal ectoderm into ventral ectoderm.
messages: Required for normal dorsal development. TLD may interact physically with DPP-C protein.

7227:Dmel CG3740
gene id: 7227:Dmel_CG3740
uniprot id: Q9W569
names: Similarity
messages: Belongs to the C19orf12 family.

7227:Dmel CG7869
gene id: 7227:Dmel_CG7869
uniprot id: Q9VTE2
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed both maternally and zygotically.
messages: Expressed throughout development. Weakly expressed. Expressed at higher level in embryos and adult females.
messages: Interacts (via SNF2-like region) with Rif1.
messages: Nucleus
messages: Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes (PubMed:11901119, PubMed:12456726, PubMed:30277458). Functions by promoting the localization and retention of Rif1 to active DNA replication forks where Rif1 inhibits replication fork progression (PubMed:30277458). Controls chromatin organization in polytene chromosomes (PubMed:12456726).
messages: The SNF2-like region is essential for localization to DNA replication forks and for promoting underreplication. It is not required for localization to heterochromatin.

7227:Dmel CG3373
gene id: 7227:Dmel_CG3373
uniprot id: Q9VB46
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the strictosidine synthase family.
messages: By ecdysone; in embryonic cell lines.
messages: Cell membrane
messages: Detected in ovaries (at protein level) (PubMed:11164341). In larvae, detected in the fat body, salivary glands, imaginal disks and gut (at protein level) (PubMed:11164341). In adults, expressed in the cardia, and in regions of the ventriculus including the area posterior to the cardia (PubMed:8662683). In females also expressed in follicle cells (PubMed:8662683).
messages: Detected throughout development and in adults (at protein level) (PubMed:11164341). Expressed in embryos, larvae and adults (PubMed:8662683).
messages: Interacts with sturkopf.
messages: O-glycosylated. Glycosylated in the ovary of 4 day old females.
messages: Phosphorylated.
messages: Transmembrane mucin that may be involved in cellular adhesion and the innate immune response (PubMed:8662683, PubMed:12769978). Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions (PubMed:8662683, PubMed:12769978, PubMed:11164341). This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen (PubMed:12769978). Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response (PubMed:8662683).

7227:Dmel CG30122
gene id: 7227:Dmel_CG30122
uniprot id: A1ZBB4
uniprot id: A8E6M1
uniprot id: E1JGL8
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG9211
gene id: 7227:Dmel_CG9211
uniprot id: Q9VM64
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. IHOG family.
messages: Expressed both maternally and zygotically.
messages: Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when facilitated by heparin, heparin is required to promote high-affinity interactions between hh and iHog.
messages: Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
messages: Membrane
messages: Patterning defects characteristic of Hh signaling loss in embryos and imaginal disks.
messages: The first Fibronectin type-III domain mediates a specific interaction with Hh protein, in vitro. The second Fibronectin type-III domain is additionally required for in vivo signaling activity.

7227:Dmel CG10756
gene id: 7227:Dmel_CG10756
uniprot id: Q9VIP1
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG8302
gene id: 7227:Dmel_CG8302
uniprot id: Q9V7G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG5320
gene id: 7227:Dmel_CG5320
uniprot id: A0A0C4DHE7
uniprot id: P54385
uniprot id: Q8IMY1
names: Activity Regulation
names: Developmental Stage
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP can occupy the NADH binding site and activate the enzyme.
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Expressed at all stages.
messages: Expressed throughout the embryo during early stages before becoming localized in mesodermal tissue by stage 8. At stage 12 expression is concentrated in the posterior midgut. After stage 13 expression it is found in the anterior and posterior midgut, the hindgut, fat body, muscle, and central nervous system. In 3rd instar larvae expression is found in the leg disks, the wing pouch of the wing disk, the eye-antenna disk, and the developing brain medulla.
messages: Homohexamer.
messages: Mitochondrion matrix
messages: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP (By similarity).

7227:Dmel CG4373
gene id: 7227:Dmel_CG4373
uniprot id: Q9W223
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG7762
gene id: 7227:Dmel_CG7762
uniprot id: Q9VW54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

7227:Dmel CG6536
gene id: 7227:Dmel_CG6536
uniprot id: Q9V817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
messages: Cell membrane

7227:Dmel CG3187
gene id: 7227:Dmel_CG3187
uniprot id: Q8IRR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

7227:Dmel CG12749
gene id: 7227:Dmel_CG12749
uniprot id: P48810
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle.

7227:Dmel CG17142
gene id: 7227:Dmel_CG17142
uniprot id: Q9W0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
messages: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites.
messages: Homooligomer; between isoform A and isoform B.
messages: Membrane
messages: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments.

7227:Dmel CG17183
gene id: 7227:Dmel_CG17183
uniprot id: Q9W0P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
messages: Nucleus

7227:Dmel CG2099
gene id: 7227:Dmel_CG2099
uniprot id: Q9VNB9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

7227:Dmel CG8890
gene id: 7227:Dmel_CG8890
uniprot id: C7LA78
uniprot id: Q9VMW9
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (also known as GDP-4-keto-6-deoxy-D-mannose or GDP-4-dehydro-alpha-D-rhamnose), an essential step in the synthesis of GDP-fucose from GDP-mannose.

7227:Dmel CG43999
gene id: 7227:Dmel_CG43999
uniprot id: Q0KI22
names: Similarity
messages: Belongs to the OPA3 family.

7227:Dmel CG8759
gene id: 7227:Dmel_CG8759
uniprot id: Q94518
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: May promote appropriate targeting of ribosome-nascent polypeptide complexes (By similarity). Required for correct localization of the osk/oskar protein to the posterior pole during embryonic development. The osk protein directs the recruitment of molecules responsible for posterior body patterning and germline formation in the embryo.
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of Nac-alpha and bicaudal (bic).

7227:Dmel CG42540
gene id: 7227:Dmel_CG42540
uniprot id: H8F4R7
uniprot id: M9NF13
uniprot id: M9PEB7
uniprot id: M9PEM4
uniprot id: M9PHF2
uniprot id: Q9VZA4
uniprot id: Q9VZA5
uniprot id: X2JC20
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane
messages: Partially edited. Target of Adar.

7227:Dmel CG4279
gene id: 7227:Dmel_CG4279
uniprot id: Q9W2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

7227:Dmel CG4270
gene id: 7227:Dmel_CG4270
uniprot id: Q7KU14
uniprot id: Q9VQA2
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG32568
gene id: 7227:Dmel_CG32568
uniprot id: Q9VXB7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7227:Dmel CG18641
gene id: 7227:Dmel_CG18641
uniprot id: Q9VQC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG14217
gene id: 7227:Dmel_CG14217
uniprot id: Q0KHQ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: In the posterior midgut, expressed in almost all intestinal cell types including intestinal stem cells and enterocytes (at protein level). Maternally expressed, ubiquitously distributed in the egg and early embryo and enriched in the germ plasm at the posterior pole of the early embryo including the pole cells.
messages: Induces in vitro expression of actin-dependent filopodia-like cytoplasmic protrusions which firmly attach to the substrate. Antagonizes the activity of isoform D.
messages: Induces in vitro expression of large, highly dynamic, microtubule-dependent lamellopodia-like cytoplasmic expansions which constantly probe the environment.
messages: Interacts with Schip1; the interaction enhances Tao kinase activity.
messages: Isoform A: Enriched in germ plasm but is degraded in pole cells immediately after pole cell formation. Isoform D: Enriched in germ plasm, partitions into pole cells and remains detectable in pole cells until they migrate through the midgut epithelium toward the overlying mesoderm.
messages: Membrane
messages: Morphological defects in the follicular epithelium where cells in the anterior part of the epithelium stay cuboidal and fail to stretch (PubMed:23266957). RNAi-mediated knockdown in eye and wing imaginal disks results in tissue overgrowth (PubMed:22075147, PubMed:22075148). It also gives rise to transcriptional up-regulation of a number of targets of the Hippo/SWH pathway (PubMed:22075147). RNAi-mediated knockdown in wing imaginal disks results in strong elevation of yki activity (PubMed:22075148). RNAi-mediated knockdown in the adult posterior midgut results in an increased number of intestinal stem cells (PubMed:25160975). RNAi-mediated knockdown in the embryo results in disordered migration of primordial germ cells out of the gut epithelium, their dispersal within the embryo and embryonic death (PubMed:25589578).
messages: Perikaryon
messages: Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein (PubMed:22075147, PubMed:22075148). In imaginal cells, phosphorylates and activates hpo and leads to repression of yki (PubMed:22075147, PubMed:22075148). In the midgut, negatively regulates the proliferation of intestinal stem cells through the Hippo/SWH pathway (PubMed:25160975). Independent of the hippo/SWH pathway, regulates epithelial morphogenesis in follicle cells by promoting the endocytosis of Fas2 and reducing lateral adhesion between epithelial cells which, in turn, permits shrinking of the lateral membrane and initiates morphogenesis of the squamous epithelium (PubMed:23266957). Required for the development of both the mushroom body and the ellipsoid body in the brain and may act as a negative regulator of the par-1 kinase (PubMed:21248138). Negatively regulates the JNK pathway which increases sensitivity to ethanol exposure (PubMed:23227189). Plays a role in the control of cell shape by negatively regulating the growth of microtubule plus-ends as they contact the actin-rich cell cortex (PubMed:20647372). Required for the induction of apoptosis in pole cells by promoting expression of skl which enhances activity of the apoptosis activator hid (PubMed:17449640).
messages: axon
messages: cell cortex
messages: cytoskeleton
messages: spindle

7227:Dmel CG8295
gene id: 7227:Dmel_CG8295
uniprot id: A0A0B4K7R5
uniprot id: A0A0B4K807
uniprot id: E1JH79
uniprot id: Q9NKV0
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MLF family.
messages: Cytoplasm
messages: Expressed at high levels in unfertilized eggs, early embryos, pupae and adult males while a low level expression is found in adult females and larvae.
messages: High levels are seen in unfertilized eggs and expression increases slightly during early embryo stages (2-3 hours). Levels are high in embryos until 4 hours after fertilization and then decrease gradually through embryonic and larval stages.
messages: Interacts with DRE-binding factor Dref.

7227:Dmel CG11821
gene id: 7227:Dmel_CG11821
uniprot id: Q9VE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion membrane

7227:Dmel CG1922
gene id: 7227:Dmel_CG1922
uniprot id: L0MPQ0
uniprot id: Q9NJB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CUT homeobox family.
messages: Neural-specific.
messages: Nucleus
messages: Transcriptional regulator. Binds and recognize ATTG sites.

7227:Dmel CG13139
gene id: 7227:Dmel_CG13139
uniprot id: Q9VKY1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the LIX1 family.
messages: Broadly expressed in the developing imaginal disks including the wing, leg and eye, and the neuroepithelium of the optic lobes of the brain. In the eye imaginal disk, expression is highest in the morphogenetic furrow and in the wing imaginal disk it is highest near the dorsal-ventral (DV) compartment boundary.
messages: Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg (PubMed:19710173, PubMed:21379328). In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds (PubMed:19710173). Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity (PubMed:21379328).
messages: Cytoplasm
messages: Interacts with ft (via intracellular domain) and ds (via intracellular domain).
messages: Viable and fertile. Wings are slightly shorter with a decreased distance between cross-veins.

7227:Dmel CG12351
gene id: 7227:Dmel_CG12351
uniprot id: C0HKA2
uniprot id: C0HKA3
uniprot id: C0HKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

7227:Dmel CG33532
gene id: 7227:Dmel_CG33532
uniprot id: Q59DY6
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Detected in larvae and expressed from the late pupal stage onwards. Highest levels of expression in adults.
messages: Galactose-specific lectin that displays calcium-dependent activity (PubMed:16475980, PubMed:17287021). Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization (PubMed:17287021). This is likely by interacting with carbohydrates on the surface of the hemocytes (PubMed:17287021). Also displays agglutination activity against the Gram-negative bacterium E.coli (PubMed:17287021).
messages: Secreted

7227:Dmel CG8687
gene id: 7227:Dmel_CG8687
uniprot id: Q9V4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG3443
gene id: 7227:Dmel_CG3443
uniprot id: M9PGB7
uniprot id: M9PGU2
uniprot id: P18490
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Expressed both maternally and zygotically.
messages: Involved in neurogenesis.
messages: Membrane

7227:Dmel CG6009
gene id: 7227:Dmel_CG6009
uniprot id: Q9V3F8
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

7227:Dmel CG3925
gene id: 7227:Dmel_CG3925
uniprot id: Q9VH36
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CRBN family.
messages: Expressed in the fat body (at protein level).
messages: Likely a component of a DCX (DDB1-CUL4-X-box) protein ligase complex (By similarity). May interact with pic/DDB1 (PubMed:27702999).
messages: Nucleus
messages: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). Has an essential role in mediating growth by negatively regulating insulin signaling (PubMed:27702999). It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae (PubMed:29530986).
messages: The name 'Ohgata' means 'large' in Japanese and refers to the overgrowth phenotype in mutants.
messages: Ubiquitinated.
messages: Viable and fertile however, adults and larvae display an increase in body size and tissue growth as a result of increased cell number (PubMed:27702999). Overgrowth is due to an up-regulation in insulin-like signaling both systematically and in the fat body, which in turn results in the down-regulation of insulin-like peptide (ILP) inhibitors, conv and ImpL2, and thus allows increased activity of the ILPs (PubMed:27702999). RNAi-mediated knockdown in the fat body results in an increase in pupal length, adult body weight and posterior wing area (PubMed:27702999).

7227:Dmel CG9090
gene id: 7227:Dmel_CG9090
uniprot id: Q7JUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG8985
gene id: 7227:Dmel_CG8985
uniprot id: M9PEC0
uniprot id: Q9W025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7227:Dmel CG42370
gene id: 7227:Dmel_CG42370
uniprot id: Q9VME2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG14724
gene id: 7227:Dmel_CG14724
uniprot id: A0A0B4KFT0
uniprot id: Q94514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

7227:Dmel CG7758
gene id: 7227:Dmel_CG7758
uniprot id: Q9U616
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

7227:Dmel CG14104
gene id: 7227:Dmel_CG14104
uniprot id: Q9VW42
names: Function
names: Similarity
messages: Belongs to the SWI5/SAE3 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.

7227:Dmel CG5271
gene id: 7227:Dmel_CG5271
uniprot id: P15357
uniprot id: Q8IGR0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: For a better understanding, features related to ubiquitin are only indicated for the first chain.
messages: In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with exact head to tail repeats.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.
messages: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

7227:Dmel CG7781
gene id: 7227:Dmel_CG7781
uniprot id: Q9VLP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiver family.
messages: Belongs to the scoloptoxin-05 family.
messages: Cell membrane
messages: Membrane
messages: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

7227:Dmel CG5855
gene id: 7227:Dmel_CG5855
uniprot id: M9PDJ6
uniprot id: P49858
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo.
messages: Belongs to the cornichon family.
messages: Detectable in the germline from germarium stages onwards and becomes enriched within the oocyte during early and middle stages of oogenesis. In early stages, it is present in the nurse cell oocyte cluster. It is highly expressed in stage 1-6 egg chambers, expression ceases during stage 7 and cannot be detected in stages 8 and 9. During stage 10, it is reexpressed in the nurse cells.
messages: Endoplasmic reticulum membrane
messages: Expressed in male and female somatic tissues.
messages: Interacts with grk.
messages: Membrane

7227:Dmel CG3704
gene id: 7227:Dmel_CG3704
uniprot id: Q9V3R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

7227:Dmel CG10538
gene id: 7227:Dmel_CG10538
uniprot id: Q9VIS1
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Expressed at all developmental stages, with highest expression at the posterior pole of the early cellular blastoderm, the neuro-ectoderm prior to neuroblast delamination, rows of epidermal cells in the most posterior part of thoracic and first abdominal segments and a ring of epidermal cells at the posterior end of the embryo.
messages: Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation.
messages: Ubiquitously expressed.

7227:Dmel CG14994
gene id: 7227:Dmel_CG14994
uniprot id: M9PH99
uniprot id: P20228
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the production of GABA.
messages: Expressed in early embryonic development (4-8 h) and in all later developmental stages.
messages: Expressed in the head (at protein level).
messages: Homodimer.
messages: RNAi-mediated knockdown in 5-HT1B+ neurons leads to dis-inhibition of male aggressive behavior.

7227:Dmel CG13951
gene id: 7227:Dmel_CG13951
uniprot id: Q9V574
names: Function
messages: Vital for development.

7227:Dmel CG5094
gene id: 7227:Dmel_CG5094
uniprot id: Q9VJD4
names: Similarity
messages: Belongs to the SGT family.

7227:Dmel CG3972
gene id: 7227:Dmel_CG3972
uniprot id: Q9V3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG9267
gene id: 7227:Dmel_CG9267
uniprot id: Q9VJX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG1264
gene id: 7227:Dmel_CG1264
uniprot id: A0A0B4K629
uniprot id: P10105
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: During embryogenesis, expressed in mandibular lobe, hypopharyngeal organ, neural and epidermal cells of procephalic lobe, sensory cells of clypeolabrum, posterior midgut, thoracic and abdominal segments.
messages: Expressed both maternally and zygotically. High expression in embryos and third instar larvae, lower expression in pupae.
messages: It is uncertain whether Met-1, Met-2 or Met-7 is the initiator.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for proper head development.

7227:Dmel CG5012
gene id: 7227:Dmel_CG5012
uniprot id: Q9VSR5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

7227:Dmel CG13502
gene id: 7227:Dmel_CG13502
uniprot id: D6W4X6
uniprot id: Q9W295
names: Subcellular Location Annotation
messages: cilium axoneme

7227:Dmel CG2316
gene id: 7227:Dmel_CG2316
uniprot id: Q7JUN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Peroxisome membrane
messages: Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation.
messages: RNAi-mediated knockdown survives to adulthood, but suffer from neurodegeneration including age-dependent retinal disorganization with retinal holes and pigment cell loss (PubMed:29739804). RNAi-mediated knockdown in the neurons results in a similar phenotype (PubMed:29739804). Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs) (PubMed:29739804). In contrast, glial-specific RNAi-mediated knockdown results in no defect (PubMed:29739804).

7227:Dmel CG8402
gene id: 7227:Dmel_CG8402
uniprot id: Q9VH81
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

7227:Dmel CG10215
gene id: 7227:Dmel_CG10215
uniprot id: Q7KMG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

7227:Dmel CG2910
gene id: 7227:Dmel_CG2910
uniprot id: Q7KMJ6
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM Spen family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:29535189, PubMed:28675155, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:27919077, PubMed:29535189, PubMed:28675155, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077, PubMed:29535189, PubMed:29555755). Interacts with Sxl (PubMed:26324914). Interacts with Hipk; leading to phosphorylation (PubMed:25040100).
messages: Female flies show stem cell tumors in the female germ line as well as female-to-male somatic transformations (PubMed:26324914).
messages: Nucleus
messages: Phosphorylated by Hipk at Ser-23, Ser-25 and/or Ser-27; the precise position if phosphorylation sites is unknown (PubMed:25040100).
messages: RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs (PubMed:27919077, PubMed:29535189, PubMed:29555755). M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:29535189, PubMed:29555755). In the WMM complex, may act by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:26324914, PubMed:29535189, PubMed:29555755). M6A methylation is also required for neuronal functions (PubMed:27919077). Acts as a positive regulator of canonical Wg signaling during wing disk and eye development (PubMed:16547102, PubMed:18174108).
messages: Widely expressed (PubMed:18174108, PubMed:25040100). Shows some enrichment in the central nervous system (PubMed:25040100).

7227:Dmel CG34049
gene id: 7227:Dmel_CG34049
uniprot id: A8WHB7
names: Subcellular Location Annotation
messages: Secreted

7227:Dmel CG18549
gene id: 7227:Dmel_CG18549
uniprot id: Q9VG64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7227:Dmel CG31275
gene id: 7227:Dmel_CG31275
uniprot id: Q7JQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: cytoskeleton

7227:Dmel CG5261
gene id: 7227:Dmel_CG5261
uniprot id: M9PCA2
uniprot id: M9PCG1
uniprot id: M9PCU4
uniprot id: Q7KTK9
uniprot id: Q9VM14
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

7227:Dmel CG33264
gene id: 7227:Dmel_CG33264
uniprot id: P82985
uniprot id: Q9VU27
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG34058
gene id: 7227:Dmel_CG34058
uniprot id: Q9VL84
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Expressed in embryonic and larval tracheal systems in the dorsal trunk and transverse connective (TC), but not in the junction between the dorsal trunk and TC, and in several tracheal branches and terminal cells. In larvae, also expressed in ventral pits. Expressed in the taste-sensing terminal organ of the larval head. In adult, expressed in hairs on the tibia, femur, tarsi of the leg and wing margin.
messages: Expression is first detected during late embryogenesis, at stage 15 in the dorsal trunk. At stage 16, expression is observed in the TC and extends into the primary branches. By stage 17, expression is more extensive in the primary branches and in some secondary branches.
messages: Membrane
messages: Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport.

7227:Dmel CG16986
gene id: 7227:Dmel_CG16986
uniprot id: Q9VZZ5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

7227:Dmel CG30170
gene id: 7227:Dmel_CG30170
uniprot id: Q9W1I2
names: Function
names: Tissue Specificity
messages: Essential cystoblast differentiation factor required for Bam function in asymmetric division of the germline stem cells.
messages: Expressed in testis and in 5-8 germline stem cells of ovaries, immediately adjacent to terminal filament.

7227:Dmel CG11600
gene id: 7227:Dmel_CG11600
uniprot id: Q9VG48
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7227:Dmel CG10933
gene id: 7227:Dmel_CG10933
uniprot id: A1ZAY1
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with dachs (via C-terminus); the interaction is direct. Interacts (via N-terminus including SH3 domain 1) with palmitoyltransferase app; this leads to palmitoylation of Dlish by app. Also interacts with dco, ft, ft-regulated E3 ubiquitin ligase Fbxl7, F-box protein slmb and SCF E3 ubiquitin-protein ligase complex component Cul1.
messages: Palmitoylated by app.
messages: RNAi-mediated knockdown results in reduced spacing between the anterior and posterior crossveins of the wing, reduced levels of subapical cortical dachs, increased levels of dachs throughout the cytoplasm, increased total cellular levels of dachs and suppression of the overgrowth and dachs up-regulation seen in ft mutants.
messages: Required for the apical cell cortex localization, total cellular level and full activity of dachs.
messages: cell cortex

7227:Dmel CG14718
gene id: 7227:Dmel_CG14718
uniprot id: Q9VGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

7227:Dmel CG14508
gene id: 7227:Dmel_CG14508
uniprot id: Q9VAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG11722
gene id: 7227:Dmel_CG11722
uniprot id: Q9VH39
names: Similarity
messages: Belongs to the NDUFAF4 family.

7227:Dmel CG33835
gene id: 7227:Dmel_CG33835
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG17515
gene id: 7227:Dmel_CG17515
uniprot id: Q7PLE9
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

7227:Dmel CG7885
gene id: 7227:Dmel_CG7885
uniprot id: O97183
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

7227:Dmel CG3505
gene id: 7227:Dmel_CG3505
uniprot id: Q8SX54
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. CLIP subfamily.
messages: Secreted
messages: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

7227:Dmel CG1265
gene id: 7227:Dmel_CG1265
uniprot id: Q9VZF3
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10306
gene id: 7227:Dmel_CG10306
uniprot id: Q9W2D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
messages: Cytoplasm

7227:Dmel CG8996
gene id: 7227:Dmel_CG8996
uniprot id: Q7KN94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

7227:Dmel CG9702
gene id: 7227:Dmel_CG9702
uniprot id: A0A0B4KI30
uniprot id: Q9VA55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG17751
gene id: 7227:Dmel_CG17751
uniprot id: Q9VDV8
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG14340
gene id: 7227:Dmel_CG14340
uniprot id: Q9VPW6
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

7227:Dmel CG7435
gene id: 7227:Dmel_CG7435
uniprot id: Q06849
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Ubiquitously expressed.

7227:Dmel CG34358
gene id: 7227:Dmel_CG34358
uniprot id: M9NGR8
uniprot id: P33085
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Flies fail to jump in response to a light-off stimulus. Neural-specific mutants exhibit modified giant fiber system and gustatory response.
messages: Isoform Neural is expressed in synapses of giant fibers (GF), in a large thoracic cell in location of postsynaptic target and optic lobe lamina and medulla. Isoform Lethal is expressed in embryonic mesodermal derivatives. During metamorphosis, both isoforms are dynamically expressed in pupal nervous system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer (isoform Lethal).
messages: Structural component of the gap junctions at electrical synapses in distal and mid-depth levels in the lamina. Isoform Lethal forms voltage sensitive intercellular channels through homotypic interactions.
messages: Structural component of the gap junctions.
messages: gap junction

7227:Dmel CG6508
gene id: 7227:Dmel_CG6508
uniprot id: Q9VKP7
names: Similarity
messages: Belongs to the peptidase A1 family.

7227:Dmel CG14207
gene id: 7227:Dmel_CG14207
uniprot id: M9NHC5
uniprot id: Q8IQW5
uniprot id: Q9VWG1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7227:Dmel CG8817
gene id: 7227:Dmel_CG8817
uniprot id: A0A1W5PXG3
uniprot id: M9PCF6
uniprot id: Q9VQI9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AF4 family.
messages: Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear.
messages: Embryos lacking maternal lilli show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. Adults lacking lilli exhibit reduction in cell and organ size and partial suppression of the increased growth associated with loss of PTEN function.
messages: Expressed both maternally and zygotically.
messages: Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
messages: Nucleus

7227:Dmel CG13277
gene id: 7227:Dmel_CG13277
uniprot id: Q9VJI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

7227:Dmel CG1049
gene id: 7227:Dmel_CG1049
uniprot id: Q7K4C7
names: Similarity
messages: Belongs to the cytidylyltransferase family.

7227:Dmel CG6347
gene id: 7227:Dmel_CG6347
uniprot id: Q7K0S6
names: Similarity
messages: Belongs to the peptidase C1 family.

7227:Dmel CG3779
gene id: 7227:Dmel_CG3779
uniprot id: P16554
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In larval brain, leads to overgrowth and defective differentiation halting the development of secondary neuroblasts beyond the stage of immature type II intermediary neuronal progenitors (INP).
messages: Interacts with Nak.
messages: Nucleus
messages: PTB domain recognizes multiple ligands by engaging different amounts of surface area dictated by tertiary contacts rather than primary sequence. This may allow interactions with a diverse set of proteins during asymmetric division and specification of cell fate.
messages: Phosphorylated by aPKC which lowers lipid affinity and promotes dissociation from the cell cortex.
messages: Required in determination of cell fate during sensory organ formation in embryos (PubMed:2752427). Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling (PubMed:24550111, PubMed:28899667, PubMed:18342578).
messages: The phospho-regulated basic and hydrophobic (PRBH) motif is necessary and sufficient for interaction with phospholipids permitting cortical localization (PubMed:26481050). Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane (PubMed:26481050).
messages: cell cortex

7227:Dmel CG3014
gene id: 7227:Dmel_CG3014
uniprot id: Q9VHZ9
names: Similarity
messages: Belongs to the arrestin family.

7227:Dmel CG1519
gene id: 7227:Dmel_CG1519
uniprot id: Q9V5C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with ntc.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

7227:Dmel CG31957
gene id: 7227:Dmel_CG31957
uniprot id: M9PEE8
uniprot id: Q8IQ13
names: Similarity
messages: Belongs to the EIF1AD family.

7227:Dmel CG12028
gene id: 7227:Dmel_CG12028
uniprot id: Q9NGX9
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Complex coexpression pattern of dib (disembodied) and sad (shade) in the early embryo that restricts to the prothoracic gland cells of the developing ring gland during late embryogenesis. In larvae and adult, coexpression is seen in prothoracic gland and follicle cells of the ovary. In adults, coexpression is seen in the follicle cells.
messages: Expression starts during embryonic blastoderm stages and is absent by stages 12/13. Reappears in stage 16.
messages: Member of the Halloween gene group.
messages: Mitochondrion membrane
messages: Required for CNS development; negatively regulates glial cell division in the embryonic midline. Involved in the metabolism of insect hormones; responsible for ecdysteroid C22-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.

7227:Dmel CG3127
gene id: 7227:Dmel_CG3127
uniprot id: M9PCE0
uniprot id: Q01604
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

7227:Dmel CG7382
gene id: 7227:Dmel_CG7382
uniprot id: Q9VMR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG1263
gene id: 7227:Dmel_CG1263
uniprot id: Q9V3G1
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically in all stages.
messages: In larvae tissues examined: gut, brain imaginal disk, salivary glands, fat body, muscles, epidermis and trachaea.

7227:Dmel CG32397
gene id: 7227:Dmel_CG32397
uniprot id: M9NE38
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Important for normal assembly of actin bundles during bristle formation.
messages: RNAi-mediated knockdown results in abnormal bristle morphology. The bristle ridges are shallower than wild-type and become nonparallel and disorganized near the tip. The tip of the bristle is swollen giving it a javelin-like appearance. In 13% of animals the posterior scutellar bristles are fused.
messages: cytoskeleton

7227:Dmel CG18106
gene id: 7227:Dmel_CG18106
uniprot id: O77150
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bomanin family.
messages: By bacterial infection.
messages: Hemolymph (at protein level).
messages: Secreted
messages: Secreted immune-induced peptide induced by Toll signaling (PubMed:9736738, PubMed:25915418, PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:9736738, PubMed:25915418, PubMed:29920489).

7227:Dmel CG34341
gene id: 7227:Dmel_CG34341
uniprot id: M9MRK1
uniprot id: M9MSJ0
uniprot id: Q9VJ79
uniprot id: X2J6P6
uniprot id: X2J8Z1
names: Cofactor
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: In adults, it is enriched in Malpighian tubules.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Dual-specificity phosphodiesterase that catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

7227:Dmel CG1511
gene id: 7227:Dmel_CG1511
uniprot id: D1YSF9
uniprot id: Q0KIF4
uniprot id: Q59DQ4
uniprot id: Q8IMC2
uniprot id: Q9V4E5
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG10175
gene id: 7227:Dmel_CG10175
uniprot id: A0A0B4LHM3
uniprot id: Q8IMY6
uniprot id: Q8MQQ0
uniprot id: Q9VCL6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7227:Dmel CG11466
gene id: 7227:Dmel_CG11466
uniprot id: Q9VG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG15261
gene id: 7227:Dmel_CG15261
uniprot id: Q9V3W0
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Molecular chaperone. Seems to fulfill an ATP-independent, HSP70-like function in protein folding. May protect essential factors of cell proliferation during heat shock. No role in calpain activation.

7227:Dmel CG2859
gene id: 7227:Dmel_CG2859
uniprot id: Q9U5W9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At embryonic stage 9, highest expression is detected within the ectoderm, ventral chord, and anterior foregut primordium. Later in development preferential expression is in the foregut, proventriculus, and central nervous system. Coexpressed with Taf10b in the lateral epidermis and anal plate.
messages: Belongs to the TAF10 family.
messages: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Also a member of the histone acetylase (HAT) complex.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

7227:Dmel CG7216
gene id: 7227:Dmel_CG7216
uniprot id: Q26416
names: Developmental Stage
names: Domain
names: Function
names: Tissue Specificity
messages: Component of the cuticle of the adult fruit fly. Could be involved in thickening of the hard adult cuticle.
messages: Detected in the epidermis underlying the head and thorax (including legs and wings), but not in the abdominal epidermis of newly eclosed flies.
messages: Expression starts around 72 hours after pupariation, peaks 12 hours after eclosion and decreases thereafter to undetectable levels by 3 days after eclosion.
messages: The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.

7227:Dmel CG17334
gene id: 7227:Dmel_CG17334
uniprot id: Q9VRN5
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: Cytoplasm
messages: Expressed from embryogenesis to the first instar larval stage, then at the pupal stage. Not expressed at significant levels in the adult.

7227:Dmel CG17245
gene id: 7227:Dmel_CG17245
uniprot id: H9XVL5
uniprot id: Q9V4A7
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Highly expressed in the embryonic and larval nervous system.
messages: Interacts with PlexA. Interacts with Rho1 and with the active forms of Rac1 and Rac2. Interacts with Sema-2a.
messages: Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7227:Dmel CG13633
gene id: 7227:Dmel_CG13633
uniprot id: Q9VC44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the allatostatin family.
messages: May act as a neurotransmitter or neuromodulator.
messages: Secreted

7227:Dmel CG11306
gene id: 7227:Dmel_CG11306
uniprot id: Q9VP06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

7227:Dmel CG5212
gene id: 7227:Dmel_CG5212
uniprot id: A8JR89
uniprot id: O77237
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pellino family.
messages: Expressed both maternally and zygotically with low levels of expression throughout the life cycle.
messages: Interacts with pll.
messages: Scaffold protein involved in the Toll signaling pathway via its interaction with pelle/pll kinase.

7227:Dmel CG7230
gene id: 7227:Dmel_CG7230
uniprot id: A0A0B4KFC4
uniprot id: Q7KF43
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG33819
gene id: 7227:Dmel_CG33819
uniprot id: P02255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus
messages: Phosphorylated in oocytes during prophase I of meiosis.

7227:Dmel CG3944
gene id: 7227:Dmel_CG3944
uniprot id: Q9VF27
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Expressed in muscles (at protein level).
messages: Mitochondrion
messages: Part of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:28683319). This is a component of the iron-sulfur (IP) fragment of the enzyme (PubMed:28683319).
messages: RNAi-mediated knockdown is lethal (PubMed:29285794). RNAi-mediated knockdown in the muscles impairs biogenesis of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:28683319). RNAi-mediated knockdown in neurons impairs neuronal ATP production, reduces locomotor activity and shortens lifespan (PubMed:29285794). In addition, results in large vacuoles in the retina, ommatidia disorganization and selective axonal alterations in mushroom bodies (PubMed:29285794). RNAi-mediated knockdown in glia results in large vacuoles and lipid droplets in both cortical region of the brain and optic lobes suggesting altered lipid metabolism; does not alter lifespan or behavior (PubMed:29285794).

7227:Dmel CG4609
gene id: 7227:Dmel_CG4609
uniprot id: M9PFH6
uniprot id: M9PFW1
uniprot id: Q59E29
uniprot id: Q59E30
uniprot id: Q86BI4
uniprot id: Q95RI5
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the FAX family.
messages: Not detected in pregastrula embryos. Upon gastrulation, detected in the epidermis and visceral mesoderm. The expression pattern undergoes a pronounced change, such that epidermal expression decreases to background levels while mesodermal expression remains high. Visceral mesoderm expression decreases once formation of the gut tube is complete. Concurrently, central nervous system expression intensifies. Also detected in the peripheral nervous system.
messages: Together with Abl, involved in embryonic axonal development.

7227:Dmel CG11141
gene id: 7227:Dmel_CG11141
uniprot id: Q6NLL1
names: Similarity
messages: Belongs to the WD repeat KIAA0329 family.

7227:Dmel CG11607
gene id: 7227:Dmel_CG11607
uniprot id: P10035
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the H2.0 homeobox family.
messages: Expressed in cells of the visceral musculature and its anlagen.
messages: May play a role in pattern formation during embryonic and imaginal development. Is not essential for visceral muscle morphogenesis.
messages: Nucleus

7227:Dmel CG9272
gene id: 7227:Dmel_CG9272
uniprot id: Q9VIH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

7227:Dmel CG8202
gene id: 7227:Dmel_CG8202
uniprot id: Q9VHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos.
messages: Belongs to the VPS35L family.
messages: Component of the heterotrimeric retriever complex.
messages: Endosome

7227:Dmel CG7438
gene id: 7227:Dmel_CG7438
uniprot id: Q23978
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Binds to F-actin (PubMed:7589814). Interacts with arm (PubMed:16598259, PubMed:22491943). Interacts with shg (PubMed:22491943). Interacts with ds (via intracellular region) (PubMed:26073018).
messages: Cell junction
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Expressed both maternally and zygotically throughout development to adulthood with highest levels at the end of larval development. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. Detected in the developing hindgut and midgut in stage 12 and stage 14 embryos (at protein level) (PubMed:16598258). In third instar larvae, detected in a symmetrical, double chevron-like pattern in the ventral section of segment A8 of the male genital disk, with one chevron in the anterior and the other in the posterior part of this segment (PubMed:16598259, PubMed:22491943). Detected in the H1 domain of the larval imaginal disk (PubMed:26073018). Detected in embryonic anterior and posterior midgut, hindgut, and in salivary gland (PubMed:25659376).
messages: In the embryo, expressed in gastric caeca, midgut cells of the proventriculus, and in the mid and hindgut. In the larval gut brush border, expression is in the terminal web domain. In the adult gut brush border, expression remains in the web domain and has also moved into the microvilli. Also expressed at low levels in follicle cells during oogenesis.
messages: Overexpression throughout the embryo reverses the normal left-right asymmetry of the embryonic gut, giving rise to a gut that is a mirror-image of the wild-type (PubMed:16598258). Ectopic expression in the larval epidermis causes dextral twisting of the entire larval body. Ectopic expression in tracheal precursor cells causes dextral spiraling of tracheal branches, giving rise to a spiraling ribbon shape instead of the normal smooth tube. Ectopic expression in epithelial cells causes increased elongation and a clear shift of the membrane orientation toward one side, so that the membrane is no longer perpendicular to the anterior-posterior axis (PubMed:30467170).
messages: Represents an unconventional myosin that should not be confused with the conventional myosin-1.
messages: The actin-binding domain is essential for activity in determining left-right asymmetry.
messages: The myosin motor domain contains the derminants for dextral twisting.
messages: The two IQ domains are essential for activity in determining left-right asymmetry.
messages: Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Generates left-right asymmetry at the level of single cells, organs and the whole body via its interaction with the actin cytoskeleton, both in the embryo and the adult (PubMed:16598258, PubMed:16598259, PubMed:18521948, PubMed:26073018, PubMed:25659376, PubMed:30467170). Normal left-right asymmetry of the larval midgut and hindgut requires expression in the embryonic hindgut epithelium during a critical time period, 10 to 12.75 hours after egg laying (PubMed:18521948). This period corresponds to a late stage of germband retraction, and precedes left-right asymmetric morphogenesis (PubMed:18521948). Expression in segment H1 of the imaginal ring is required at 0 to 24 hours after pupation for changes of cell shape and orientation in the H2 segment, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:16598258, PubMed:26073018). Required during a critical period, 126-132 hours after egg laying, for normal, dextral rotation of the adult male genitalia (PubMed:16598258, PubMed:16598259, PubMed:22491943, PubMed:26073018, PubMed:25659376). Has a double role by promoting dextral rotation in the posterior compartment of segment A8 of the male genital disk, and in repressing sinistral looping in the anterior compartment (PubMed:16598259).
messages: Viable and fertile (PubMed:16598258). Mutant embryos and adults display normal foregut left-right asymmetry, but inverted left-right asymmetry of the midgut and hindgut (PubMed:16598258, PubMed:18521948). RNAi-mediated knockdown in the hindgut at 0 to 24 hours after pupation leads to inverted left-right asymmetry of the adult hindgut, but knockdown at later stages has little or no effect (PubMed:16598258, PubMed:26073018). Adults display inverted left-right asymmetry of the male genitalia (PubMed:16598258). RNAi-mediated knockdown in the anterior and the posterior part of segment A8 of the male genital disk causes loss of the normal dextral rotation of the genital plate and inverted, sinistral spermiduct looping (PubMed:16598259, PubMed:26073018). Selective RNAi-mediated down-regulation in the anterior part of segment A8 of the male genital disk leads to partial dextral rotation of the genitalia, while RNAi-mediated down-regulation in the posterior part of segment A8 leads to non-rotated genitalia (PubMed:16598259). Combined RNAi-mediated knockdown of both ds and Myo31DF in the H1 segment of the imaginal ring causes mislooping of the adult hindgut (PubMed:26073018).
messages: adherens junction
messages: cell cortex
messages: cytoskeleton

7227:Dmel CG1567
gene id: 7227:Dmel_CG1567
uniprot id: Q9VZ44
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

7227:Dmel CG16720
gene id: 7227:Dmel_CG16720
uniprot id: P28285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.

7227:Dmel CG18279
gene id: 7227:Dmel_CG18279
uniprot id: C0HLZ9
uniprot id: C0HM00
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bacterial infection (at protein level) (PubMed:9736738, PubMed:16510152). Detected within 24 hours of infection (PubMed:9736738). Up-regulated in the fat body following infection with M.luteus, with expression levels increasing from 2 to 48 hours post infection (PubMed:34432851). In adults, also up-regulated in the head including the border of the eyes and the ocelli, and in the brain tissue including the region posterior to the central brain furrow (PubMed:34432851). Up-regulated in the wing veins, along the borders of the thoracic pleura, and in the spermatheca of females (PubMed:34432851). In larvae, induced in the brain tissue at the posterior of the ventral nervous system (PubMed:34432851).
messages: Hemolymph (at protein level).
messages: In some wild flies and common laboratory strains, the BaraA locus has undergone a duplication event to produce two identical paralogs, BaraA1 and BaraA2 (PubMed:34432851). However BaraA copy number varies within these strains indicating that the duplication event is recent and not fixed (PubMed:34432851).
messages: Proteolytically cleaved.
messages: Secreted
messages: Secreted immune-induced peptides induced by Toll signaling (PubMed:9736738, PubMed:34432851). Has a significant role in resistance to infection by the entomopathogenic fungus B.bassiana R444 and weak antifungal activity against M.rileyi PHP1705 (PubMed:34432851). In adult males, activity appears to be important for neuromuscular processes that mediate correct wing posture upon Toll activation (PubMed:34432851).
messages: The name 'Baramicin' derives from the Japanese idiom Bara-Bara, meaning to break apart, and refers to the multiple peptides produced from the precursor protein.
messages: Viable with no obvious morphological defects, however flies have an increased susceptibility to entomopathogenic fungi (PubMed:34432851). Displays increased fungal load 48 hours after infection with B.bassiana R444 spores resulting in a significant decrease in survival (PubMed:34432851). Survival is also slightly decreased following septic injury with M.rileyi PHP1705 (PubMed:34432851). Some adult males display an erect wing phenotype upon infection with Gram-positive bacteria, fungi, and to a lesser extent, Gram-negative bacteria and clean injury (PubMed:34432851). Males also display the erect wing phenotype after injury with heat-killed E.faecalis suggesting that the phenotype occurs due to Toll activation and is not the result of infection (PubMed:34432851). No effect on activation of the Toll or imd/NF-kappa-B signaling cascades in response to microbial infection (PubMed:34432851). No significant affect on lifespan, resistance to bacterial infection and survival following clean injury (PubMed:34432851).

7227:Dmel CG33824
gene id: 7227:Dmel_CG33824
uniprot id: P02299
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by Haspin during mitosis and interphase (PubMed:32750047). Phosphorylation at Ser-11 by aurB/ial during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259). Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome (PubMed:11114889, PubMed:11266459, PubMed:11371341, PubMed:12514098, PubMed:15175259).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG8780
gene id: 7227:Dmel_CG8780
uniprot id: Q9VW27
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In embryos, M12 position is closer to the ventral nerve cord and situated ventral to muscle 13 (M13) and external to muscle 6/7 (PubMed:20504957). The longitudinal orientation of M12 is also oblique probably due to an alteration in the muscle attachment sites (PubMed:20504957). Also displays a reduced number of synaptic sites on M12. No effect on muscle fiber size (PubMed:20504957). RNAi-mediated knockdown results in the fusion of the costal vein with the L1 vein in the developing wing, producing an adult wing that has a continuous wing margin with no separation between the end of the costal and L1 veins (PubMed:17028348). The medial and distal regions of the costal vein are also fused (PubMed:17028348). Thickening of the costal vein often occurs, and sometimes spans the region between the costal and subcostal veins (PubMed:17028348).
messages: In embryos, expressed specifically in M12 (at protein level).
messages: Nucleus
messages: Required for the correct synaptic targeting of motoneurons RP5 and V to muscle 12 (M12) (PubMed:20504957). May be involved in the negative regulation of Tl in M12 (PubMed:20504957). Involved in the correct patterning of veins in the proximal (costal) region of the wing blade (PubMed:17028348).

7227:Dmel CG3781
gene id: 7227:Dmel_CG3781
uniprot id: Q9W422
names: Function
messages: May act as a deubiquitinating enzyme.

7227:Dmel CG18340
gene id: 7227:Dmel_CG18340
uniprot id: M9NDG1
uniprot id: Q8IPK1
uniprot id: Q9VMK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG33192
gene id: 7227:Dmel_CG33192
uniprot id: Q8I9B4
names: Domain
names: Function
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 5 family.
messages: This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity).

7227:Dmel CG8668
gene id: 7227:Dmel_CG8668
uniprot id: Q9VLS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Membrane

7227:Dmel CG5576
gene id: 7227:Dmel_CG5576
uniprot id: Q7K4Z4
names: Disruption Phenotype
names: Function
names: PTM
names: Subunit
messages: Caspase-mediated cleavage is required for activation and function; upon immune stimulation, peptidoglycans (PGN) induce proteolytic cleavage by caspases such as Dredd leading to its ubiquitination.
messages: Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria (PubMed:7568155, PubMed:8808632, PubMed:11266367, PubMed:12433364). Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway (PubMed:7568155, PubMed:11269502, PubMed:11703941, PubMed:12433364, PubMed:20122400). Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex (PubMed:11269502, PubMed:12433364, PubMed:20122400). Once in proximity, Dredd cleaves imd in a Fadd-dependent manner to enable its association and activation by the ubiquitin E3-ligase DIAP2 (PubMed:20122400). The activated form of imd recruits and activates the Tab2/Tak1 complex thus acting upstream of the IKK complex (ird5 and key) to activate Rel and induce the expression of antimicrobial peptides such as Def, Dpt and Cecropin (PubMed:7568155, PubMed:8808632, PubMed:11703941, PubMed:12433364, PubMed:19837371, PubMed:20122400, PubMed:11266367). Also able to inhibit the viral replication of the Sindbis virus (PubMed:19763182). Involved in promoting the polyubiquitination and stability of faf which in turn, regulates the Imd pathway by controlling imd polyubiquitination and/or stability; they may therefore form a regulatory feedback mechanism within the Imd pathway (PubMed:23919485). Not required for the cuticle melanization immune response to bacterial challenge (PubMed:11266367).
messages: Interacts with Fadd (PubMed:12433364). Interacts with faf (PubMed:23919485). Interacts with Rpt6 (PubMed:25027767). Interacts (via N-terminus) with Usp2 (via N-terminus) (PubMed:25027767). Interacts (via N-terminus) with scny (via C-terminus) (PubMed:19837371). The N-terminally cleaved form interacts (via IAP-Binding motif) with Diap2 (via the BIR2 and BIR3 domains); the interaction promotes ubiquitination by Diap2 and the E2 ligases Uev1A, ben and Ubc5 (PubMed:20122400).
messages: Phosphorylated.
messages: RNAi-mediated knockdown in the fat body results in reduced expression of the antimicrobial peptide gene Dpt following infection with E.coli.
messages: Ubiquitination is essential for function; after PGN-induced caspase-mediated cleavage the N-terminally cleaved imd interacts with the E3 ligase Diap2 leading to polyubiquitination of 'Lys-63'-linked chains involving the E2 complex members Uev1A, ben and Ubc5 (PubMed:20122400). These 'Lys-63' chains stabilize imd and may serve as scaffolds to recruit and activate the key kinases TAK1 and IKK (PubMed:20122400). Under normal unchallenged conditions, scny deubiquitinates the activating 'Lys-63'-linked chains to prevent signal transduction and this is also likely to promote the polyubiquitination of 'Lys-48'-linked chains which act as 'tags' for proteosomal degradation (PubMed:19837371). Usp2 then deubiquitinates the 'Lys-48'-linked chains and this promotes degradation of imd probably by allowing interaction between imd and the proteasome (PubMed:25027767).

7227:Dmel CG7889
gene id: 7227:Dmel_CG7889
uniprot id: Q9VWJ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

7227:Dmel CG11734
gene id: 7227:Dmel_CG11734
uniprot id: Q9VR91
names: Function
names: Subcellular Location Annotation
messages: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: centriole

7227:Dmel CG1862
gene id: 7227:Dmel_CG1862
uniprot id: Q9V4E1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG32225
gene id: 7227:Dmel_CG32225
uniprot id: Q8IQV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

7227:Dmel CG3616
gene id: 7227:Dmel_CG3616
uniprot id: Q9W130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG6097
gene id: 7227:Dmel_CG6097
uniprot id: Q9VTK2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At the cellular blastoderm stage, expression accumulates in the ventrally located mesoderm primordium. At germ band extension, mesoderm expression is seen as stripes of strong expression. A very strong signal is also detected in the invaginating gut. As the germ band retracts, mesodermal expression decays and becomes restricted to somatic muscle precursors. After dorsal closure, expression has disappeared from the mesoderm and remains in the endoderm. Some expression is detected in a few cells of the head and the pharyngeal muscles.
messages: Belongs to the glycosyltransferase 39 family.
messages: Death during development, the few adult escapers exhibit clockwise rotation of the abdomen and defects in embryonic muscle development.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Zygotic expression peaks at embryonic stages 8-16.
messages: Interacts with tw/POMT2.
messages: Intron retention.
messages: Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.

7227:Dmel CG7839
gene id: 7227:Dmel_CG7839
uniprot id: Q9VTE6
names: Similarity
messages: Belongs to the CBF/MAK21 family.

7227:Dmel CG10396
gene id: 7227:Dmel_CG10396
uniprot id: A0A0B4KEI0
uniprot id: Q8T4H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

7227:Dmel CG11390
gene id: 7227:Dmel_CG11390
uniprot id: Q9W1C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect A10/OS-D protein family.
messages: Protein component of the posterior mating plug.
messages: Secreted
messages: Specifically expressed in the ejaculatory bulb and seminal fluid.

7227:Dmel CG7347
gene id: 7227:Dmel_CG7347
uniprot id: Q9VVN4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATRIP family.
messages: Cytoplasm
messages: DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development.
messages: Expressed both maternally and zygotically.
messages: Highly expressed in the oocyte and nurse cells from stage 5 onward and in embryos prior to during nuclear division 14. Then, it decreases to background levels during interphase 14. Weakly or not expressed in stage embryos and imaginal disks.
messages: Interacts with ATR/mei-41.
messages: The EEXXXDDL motif is required for the interaction with ATR/mei-41.

7227:Dmel CG18672
gene id: 7227:Dmel_CG18672
uniprot id: A0A0B4LHX0
uniprot id: A0A0B4LHX8
uniprot id: Q9V9Y7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7227:Dmel CG6957
gene id: 7227:Dmel_CG6957
uniprot id: M9NCR7
uniprot id: M9ND31
uniprot id: M9NE92
uniprot id: Q9VMP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

7227:Dmel CG5034
gene id: 7227:Dmel_CG5034
uniprot id: Q9VKZ0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG34379
gene id: 7227:Dmel_CG34379
uniprot id: A0A0B4LFC0
uniprot id: A1Z9P3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the shroom family.
messages: Binds (via N-terminus) to F-actin (PubMed:20549743).
messages: Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction (PubMed:20549743, PubMed:22493320). During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826). May be involved in the assembly of microtubule arrays during cell elongation (By similarity).
messages: During axis elongation in the embryo decreases localization to adherens junctions and planar polarization for both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826). The mislocalization of sqh impairs the generation of sustained actomyosin contractility during cell rearrangement and can account for the reduction in the formation of multicellular rosette and convergent extension (PubMed:24535826). RNAi-mediated knockdown in the embryo decreases Rho-kinase Rok localization to adherens junctions and planar polarization during axis elongation (PubMed:24535826). Has no effect on Rho1 localization or activity (PubMed:24535826). Isoform D: RNAi-mediated knockdown in the embryo, ecreases localization to adherens junctions and planar polarization for both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826).
messages: Expressed in the embryo (at protein level) (PubMed:20549743). Expressed in the dorsal trunk of the trachea (at protein level) (PubMed:20549743). Isoform D: Expressed in the invaginating foregut (at protein level) (PubMed:20549743). Planar polarized during axis elongation from stage 7 (at protein level) (PubMed:24535826).
messages: Monomer or homodimer (PubMed:22493320). Interacts with Rok (PubMed:22493320).
messages: The ASD2 domain mediates the interaction with Rok and is required for apical constriction induction.
messages: adherens junction
messages: cytoskeleton

7227:Dmel CG42640
gene id: 7227:Dmel_CG42640
uniprot id: Q9W1V6
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Chimeric cDNA. It is a chimera between Dox-A3 and CG8193.
messages: Expression is very low during all stages of development.
messages: Secreted
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone (By similarity).
messages: Upon activation, a trypsin type protease cleaves prophenol oxidase to yield the active enzyme.

7227:Dmel CG6431
gene id: 7227:Dmel_CG6431
uniprot id: M9MRT1
uniprot id: Q9VKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG10360
gene id: 7227:Dmel_CG10360
uniprot id: P14199
names: Disruption Phenotype
names: Function
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with aPKC and Traf6.
messages: Males are sterile, spermatids exhibit degenerated mitochondria. Reduced activation of the Drs promoter. Double mutants for ref(2)P and scny die 96 hours after egg laying (PubMed:22622177).
messages: Nucleus
messages: Polymorphic for two allelic forms in natural populations of Drosophila melanogaster, ref(2)Po and ref(2)Pp. The latter allele confers resistance to the rhabdovirus sigma infecting wild populations.
messages: Required for selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs (PubMed:12446795, PubMed:2510997).

7227:Dmel CG1924
gene id: 7227:Dmel_CG1924
uniprot id: Q9I7S9
names: Similarity
messages: Belongs to the calreticulin family.

7227:Dmel CG3267
gene id: 7227:Dmel_CG3267
uniprot id: H0RNI1
uniprot id: Q9V9A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AccD/PCCB family.
messages: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival.
messages: Expressed in third instar larval ring gland (lateral and medial secretory cells and corpus cardiacum cells) and CNS.
messages: Mitochondrion matrix

7227:Dmel CG42668
gene id: 7227:Dmel_CG42668
uniprot id: A0A0B4JCZ0
uniprot id: A0A0B4JDD8
uniprot id: A0A0B4JDG2
uniprot id: B7Z0M9
uniprot id: Q7KSB3
uniprot id: Q8IN55
uniprot id: Q8IN56
uniprot id: Q9I7I8
names: Similarity
messages: Belongs to the OSBP family.

7227:Dmel CG10248
gene id: 7227:Dmel_CG10248
uniprot id: Q27593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Microsome membrane

7227:Dmel CG12194
gene id: 7227:Dmel_CG12194
uniprot id: E1JHT4
uniprot id: Q9VR34
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG33865
gene id: 7227:Dmel_CG33865
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG8359
gene id: 7227:Dmel_CG8359
uniprot id: Q9VHL0
names: Subcellular Location Annotation
messages: Nucleus

7227:Dmel CG13011
gene id: 7227:Dmel_CG13011
uniprot id: Q9VXD1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By Mef2 during myoblast fusion in developing muscles of embryos and pupae.
messages: Essential for myoblast fusion in developing embryos and pupae, and consequently is essential for muscle formation in adults (PubMed:17537424, PubMed:25797154). Required for progression past the pre-fusion complex stage of myoblast fusion (PubMed:17537424).
messages: In embryos, expressed in the muscle founder cells (FCs) and the fusion-competent myoblasts (FCMs) (PubMed:17537424). Expressed in myoblasts of stage 13 embryos (PubMed:17537424, PubMed:25797154). Expressed in the visceral mesoderm from stage 10 and the somatic mesoderm from stage 11, and expression persists until stage 13 (PubMed:17537424).
messages: Membrane
messages: Named 'singles bar' based upon the accumulation of single myoblasts in mutant embryos.
messages: RNAi-mediated knockdown in pupae is adult lethal (PubMed:25797154). Pupae develop to the pharate adult stage and die before eclosion from the pupal case (PubMed:25797154). In pupae, fusion-competent myoblasts (FCMs) fail to fuse with the muscle founder templates (PubMed:25797154). Pharate adults display adherent muscle formation; only partially developed dorsal longitudinal muscles appear to be present but they are smaller and their nuclei are reduced in number and clustered together (PubMed:25797154). RNAi-mediated knockdown in embryos reduces myoblast fusion (PubMed:17537424). In RNAi pupae, there is no effect on myoblast proliferation, migration of the FCMs to the founder templates and initiation of myoblast fusion (PubMed:25797154).

7227:Dmel CG8725
gene id: 7227:Dmel_CG8725
uniprot id: E1JH01
uniprot id: Q9V345
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
messages: Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8. Interacts directly with CSN7.
messages: Cytoplasm
messages: Nucleus

7227:Dmel CG3173
gene id: 7227:Dmel_CG3173
uniprot id: Q9W1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 1 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS12 and IntS9 (PubMed:23288851). Interaction with IntS12 is likely to be important for promoting 3'-end processing of snRNAs (PubMed:23288851). Interacts with Mediator complex members Cdk8 and CycC (PubMed:23097424).
messages: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS12 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
messages: Nucleus membrane

7227:Dmel CG13880
gene id: 7227:Dmel_CG13880
uniprot id: Q9W0S6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

7227:Dmel CG4211
gene id: 7227:Dmel_CG4211
uniprot id: Q04047
names: Developmental Stage
names: Function
messages: Expressed ubiquitously during embryonic development with prominent expression during the first 12 hours of embryogenesis.
messages: Required for normal vision and courtship behavior in Drosophila.

7227:Dmel CG5125
gene id: 7227:Dmel_CG5125
uniprot id: M9PCU0
uniprot id: P10676
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Expressed in the phototransducing compartment of photoreceptor cells, the rhabdomeres (at protein level).
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the N-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with rtp.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities (PubMed:2449973). Essential for the expression and stability of the rtp protein in the photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554).
messages: cytoskeleton

7227:Dmel CG32823
gene id: 7227:Dmel_CG32823
uniprot id: Q8IRZ3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7227:Dmel CG7636
gene id: 7227:Dmel_CG7636
uniprot id: Q9VTF8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

7227:Dmel CG14212
gene id: 7227:Dmel_CG14212
uniprot id: Q9VWF3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

7227:Dmel CG2559
gene id: 7227:Dmel_CG2559
uniprot id: P11995
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hemocyanin family.
messages: Heterohexamer, composed of three subunits, alpha, beta and gamma.
messages: Larval hemolymph.
messages: Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
messages: extracellular space

7227:Dmel CG10932
gene id: 7227:Dmel_CG10932
uniprot id: Q9W3N9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7227:Dmel CG8245
gene id: 7227:Dmel_CG8245
uniprot id: A1Z6G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

7227:Dmel CG32110
gene id: 7227:Dmel_CG32110
uniprot id: Q8IQH8
names: Similarity
messages: Belongs to the peptidase C48 family.

7227:Dmel CG7563
gene id: 7227:Dmel_CG7563
uniprot id: A0A0B4LG26
uniprot id: A8DYJ3
uniprot id: Q11002
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by millimolar concentrations of calcium, and by phosphatidylinositol 4,5-diphosphate, phosphatidylinositol 4-monophosphate, phosphatidylinositol and phosphatidic acid.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease. Involved in the organization of the actin-related cytoskeleton during embryogenesis.
messages: Cytoplasm
messages: Localized to the anterior and posterior embryonic poles just after fertilization. Becomes distributed around the polar buds and just below the pole cells of the posterior pole during cleavage cycles. During these nuclear divisions anterior localization disappears. Localized to actin caps that underlie the plasma membrane, immediately above each nucleus at cleavage cycles 8 and 9. Localized to a small set of nerve, midgut and blood cells in adults.
messages: This protein binds calcium.
messages: Undergoes calcium-dependent autolytic cleavage between Lys-54 and Asn-55, which is necessary for activation of the protein.

7227:Dmel CG14551
gene id: 7227:Dmel_CG14551
uniprot id: Q9VBH6
names: Similarity
messages: Belongs to the CFAP97 family.

7227:Dmel CG10045
gene id: 7227:Dmel_CG10045
uniprot id: P20432
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Delta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028, PubMed:20417639). Has DDT dehydrochlorinase activity (PubMed:20417639). May be involved in detoxification (PubMed:22082028).
messages: Has a specific activity toward 1-chloro-2,4-dinitrobenzene comparable to that for the mammalian glutathione S-transferases but did not have as broad a substrate specificity pattern. Has no GSH peroxidase activity.
messages: Homodimer.

7227:Dmel CG10105
gene id: 7227:Dmel_CG10105
uniprot id: Q9V719
names: Function
names: Similarity
messages: Belongs to the SIN1 family.
messages: Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

7227:Dmel CG14916
gene id: 7227:Dmel_CG14916
uniprot id: Q9VKJ7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
messages: Cell membrane
messages: Expressed in the adult labellar chemosensory neurons. Expressed in tarsal neurons for male-male courtship suppression. In larvae, is expressed in neurons of the terminal external chemosensory organ, and the dorsal and posterior external chemosensory organs.
messages: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females.
messages: Impairs avoiding N,N-Diethyl-meta-toluamide (DEET). Leads to high male courtship toward males and mated females. Also leads to diminished aggression level of males.

7227:Dmel CG9331
gene id: 7227:Dmel_CG9331
uniprot id: Q7KT11
uniprot id: Q8SZU0
uniprot id: Q9VIJ0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7227:Dmel CG5499
gene id: 7227:Dmel_CG5499
uniprot id: A0A0B4KH25
uniprot id: P08985
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5 by Tip60. Acetylation is enhanced by Ser-138 phosphorylation and promotes the exchange of the phosphorylated form with the unmodified form of H2AV.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expressed both maternally and zygotically. Expressed in embryos and adults (females only).
messages: Monoubiquitination of Lys-121 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Ser-138 occurs in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents. Phosphorylation is dependent on the DNA damage checkpoint kinases ATR and ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant His2Av forms a heterodimer with H2B.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.

7227:Dmel CG2503
gene id: 7227:Dmel_CG2503
uniprot id: Q9VN55
names: Similarity
messages: Belongs to the PAF1 family.

7227:Dmel CG2985
gene id: 7227:Dmel_CG2985
uniprot id: P02843
uniprot id: X2JD55
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: By beta-ecdysone; in males.
messages: Expressed in females only.
messages: Secreted
messages: Synthesized in the fat body and ovarian follicle cells and accumulate in the oocyte.
messages: Tyrosine sulfation occurs in the female only and plays an essential functional role.
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG33671
gene id: 7227:Dmel_CG33671
uniprot id: Q7K2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm

7227:Dmel CG4128
gene id: 7227:Dmel_CG4128
uniprot id: M9PFD8
uniprot id: Q7KTF7
uniprot id: Q7KTF8
uniprot id: Q7KTF9
uniprot id: Q8IPE2
uniprot id: Q9VL79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7227:Dmel CG10759
gene id: 7227:Dmel_CG10759
uniprot id: E2E4R7
uniprot id: Q9W3I5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Highly sensitive to the sex pheromone of the silkworm moth, bombykol. Intriguingly, the fruit fly detectors are more sensitive than the receptors of the silkworm moth, although its ecological significance is unknown. Responds also to pyrazines.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG9918
gene id: 7227:Dmel_CG9918
uniprot id: Q8ITC9
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Intron retention.
messages: Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide) (PubMed:16054112). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1 (PubMed:12177421, PubMed:16054112). The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system (PubMed:16054112).

7227:Dmel CG9790
gene id: 7227:Dmel_CG9790
uniprot id: Q9VHN1
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

7227:Dmel CG33126
gene id: 7227:Dmel_CG33126
uniprot id: M9PBN2
uniprot id: Q8SXR1
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7227:Dmel CG6876
gene id: 7227:Dmel_CG6876
uniprot id: Q9VUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

7227:Dmel CG8791
gene id: 7227:Dmel_CG8791
uniprot id: A0A0B4K6S9
uniprot id: Q8MS66
names: Subcellular Location Annotation
messages: Membrane

7227:Dmel CG15333
gene id: 7227:Dmel_CG15333
uniprot id: Q9W3L5
names: Similarity
messages: Belongs to the DM7 family.

7227:Dmel CG8251
gene id: 7227:Dmel_CG8251
uniprot id: P52029
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Cytoplasm

7227:Dmel CG3239
gene id: 7227:Dmel_CG3239
uniprot id: Q9W4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Cell membrane

7227:Dmel CG12005
gene id: 7227:Dmel_CG12005
uniprot id: Q95U54
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex (By similarity). Interacts with Xpd and galla-2 (PubMed:29361561). Binds to microtubules (PubMed:33211700).
messages: Cytoplasm
messages: Expressed in embryos (at protein level).
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (By similarity). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). Essential for diploid cell cycles, organ growth and development (PubMed:29361561). Regulates mitosis by binding to Xpd and thereby competing with the Xpd-mediated repression on the Cdk-activating kinase (CAK) complex (PubMed:29361561). Regulates the centrosomal localization of the MT regulator tacc, a downstream target of aurA kinase (PubMed:33211700). Binds to microtubules (MT) (PubMed:33211700). Regulates spindle and astral MT growth, MT stability and bundling (PubMed:33211700). In neuroblasts, necessary for timely and coordinated spindle assembly and orientation which is necessary for mitotic progression (PubMed:33211700). In young embryos, the maternal protein is important for progression through mitosis (PubMed:29361561).
messages: Midbody
messages: Nucleus
messages: Shows slowed larval development with lack of imaginal disks and microcephaly with deformed and underdeveloped optical lobes (PubMed:29361561, PubMed:33211700). Death occurs at the third larval instar stage (PubMed:29361561, PubMed:33211700). Reduced levels of Xpd in embryos (PubMed:29361561). Results in higher proportion of neuroblasts in mitosis with shorter spindle and less dense astral microtubules with defective assembly and orientation (PubMed:33211700). Loss of maternal Mms19 causes cell cycle defects in young embryos (PubMed:29361561).
messages: spindle

7227:Dmel CG1970
gene id: 7227:Dmel_CG1970
uniprot id: Q9V4E0
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

7227:Dmel CG4341
gene id: 7227:Dmel_CG4341
uniprot id: A8DYS8
uniprot id: Q9V3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

7227:Dmel CG16755
gene id: 7227:Dmel_CG16755
uniprot id: E2E4X6
uniprot id: Q9VHE6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG5002
gene id: 7227:Dmel_CG5002
uniprot id: Q7K4I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7227:Dmel CG9277
gene id: 7227:Dmel_CG9277
uniprot id: A1ZBL0
uniprot id: Q24560
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with mgr and Vhl.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7227:Dmel CG31904
gene id: 7227:Dmel_CG31904
uniprot id: Q95TF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7227:Dmel CG33823
gene id: 7227:Dmel_CG33823
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG4012
gene id: 7227:Dmel_CG4012
uniprot id: Q9W1B0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Acts as a downstream effector for the regulation of actin polymerization by Cdc42.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Flies are defective in producing fertilized eggs. Egg chambers exhibit abnormal accumulation of F-actin.
messages: Interacts tightly with GTP-bound but not GDP-bound Cdc42.

7227:Dmel CG9853
gene id: 7227:Dmel_CG9853
uniprot id: A0A0B4LGQ8
uniprot id: Q9VN19
names: Function
names: Similarity
messages: Belongs to the GET4 family.
messages: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.

7227:Dmel CG10956
gene id: 7227:Dmel_CG10956
uniprot id: Q4V3G2
names: Similarity
messages: Belongs to the serpin family.

7227:Dmel CG30382
gene id: 7227:Dmel_CG30382
uniprot id: E1JGZ9
uniprot id: Q9XZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

7227:Dmel CG1746
gene id: 7227:Dmel_CG1746
uniprot id: Q6NN09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrion membrane

7227:Dmel CG6122
gene id: 7227:Dmel_CG6122
uniprot id: Q9VKM1
uniprot id: X2J7U0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26808625, PubMed:15817569, PubMed:17346786). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:16882972). In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner (PubMed:23159368, PubMed:28472469). Involved in silencing of long terminal repeat (LTR) retrotransposons in male germline (PubMed:15817569). In testis, regulates spermatogenesis together with Tudor-SN (PubMed:26808625). In germ cells, mediates silencing at both transcriptional and post-transcriptional levels and is involved in the maintenance of populations of primary and secondary piRNAs. Piwi-mediated transcriptional silencing is accompanied by the formation of His3 'Lys-9' trimethylated (H3K9me3) euchromatin and heterochromatin (PubMed:23434410, PubMed:23392610). In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. Association with sense piRNAs is also observed but to a lesser extent. Mediates a somatic signaling mechanism required for the maintenance of germline stem cells to produce and maintain a daughter germline stem cell (PubMed:9851978, PubMed:10631171, PubMed:9199372, PubMed:16949822). It is not essential for the further differentiation of the committed daughter cell (PubMed:9851978). Acts cell autonomously to promote germline stem cell division (PubMed:9851978, PubMed:10631171). Its role in stem cell maintenance does not seem to require nuclear localization. Required maternally for the posterior localization of osk and vas and for pole cell formation during oogenesis and early e…
messages: Belongs to the argonaute family.
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed in the germarium, at low levels during oogenesis stages 1-6, at a lower level during stages 7-9, strongly at stage 10, eventually accumulates in early embryos and later in development the expression decreases (at protein level).
messages: Expressed in ovaries (at protein level) (PubMed:28472469, PubMed:31368590, PubMed:31384064). Expressed somatically in ovariole terminal filament cells, epithelial sheath cells, cap cells and follicle cells (at protein level). Expressed in nurse cells and oocytes in developing egg chambers (at protein level) (PubMed:29531043, PubMed:29735528). In embryos, accumulates in pole cells (at protein level). In larval and adult testis, expressed in a germinal proliferative center at the apical tip containing somatic hub cells and mitotically dividing germ stem cells (at protein level) (PubMed:26808625).
messages: Female mutants show normal ovarian development up to third instar larval stage (PubMed:9851978, PubMed:9199372, PubMed:26808625). However, adult mutant ovarioles contain germaria lacking germline cells and containing two normal or abnormal egg chambers as result of the failure of germline stem cell maintenance (PubMed:9851978, PubMed:9199372, PubMed:26808625). In adult testis, results in deregulation of transposon silencing (PubMed:26808625).
messages: In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:26472911, PubMed:26494711, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced co-transcriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:26472911, PubMed:26494711, PubMed:31368590, PubMed:31384064). Interacts with vas; this interaction is RNA-independent (PubMed:16949822). Interacts with Dcr-1 and Fmr1; these interactions occur in polar granules (PubMed:16949822). Interacts (via N-terminal region) with CBX5 (via chromoshadow domain) (PubMed:17875665). Forms a complex with Hsp83 and Hop; probably Hop mediates the interaction between piwi and Hsp83 (PubMed:21186352). Forms a complex with Yb body components armi and fs(1)Yb; this interaction is required for proper piRNA loading and nuclear localization of piwi (PubMed:20966047). Interaction of Piwi and fs(1)Yb is likely to occur via armi (PubMed:20966047). Interacts (via the N-terminal region when unmethylated or symmetrically methylated at Arg-10) with papi (via Tudor domain) (PubMed:21447556, PubMed:29531043). Interacts with vret (PubMed:21831924). Interacts with Panx (PubMed:26472911, PubMed:26494711). Interacts with arx (PubMed:23913921, PubMed:23913922). Interacts with Tudor-SN (PubMed:26808625). Interacts with Nup358 (via N-terminus) (PubMed:29735528). Associates with the nuclear pore complex via interaction with Elys (PubMed:28472469). Interacts with thoc5; the interaction might be partly RNA-mediated (PubMed:28472469). Interacts with xmas-2 (PubMed:28472469).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues in an Hsp83-dependent manner.
messages: Symmetrically dimethylated, most likely by csul (PubMed:19377467, PubMed:29531043). Methylation at Arg-10 enhances binding to papi whereas methylation at Arg-7, Arg-9 or Arg-11 reduces binding affinity to papi (PubMed:29531043).
messages: nucleoplasm

7227:Dmel CG3305
gene id: 7227:Dmel_CG3305
uniprot id: Q9V9S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

7227:Dmel CG8671
gene id: 7227:Dmel_CG8671
uniprot id: A2VEG3
uniprot id: M9PDD2
uniprot id: M9PDK6
uniprot id: M9PDX3
uniprot id: Q8SZ43
uniprot id: Q9VID5
names: Similarity
messages: Belongs to the FAM102 family.

7227:Dmel CG1721
gene id: 7227:Dmel_CG1721
uniprot id: Q9VAN7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7227:Dmel CG12314
gene id: 7227:Dmel_CG12314
uniprot id: Q9VKD7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
messages: Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.
messages: Defects in mid oogenesis. Females are viable but produce eggs with a range of dorso-ventral patterning defects. Flies lay few eggs, all of which are completely ventralized and often collapsed. Effects are due to defects in piRNA biogenesis and derepression of retrotransposons. Defects are not only present in germ cells but also in somatic cells of the ovary.
messages: Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).
messages: In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
messages: Mitochondrion outer membrane

7227:Dmel CG8416
gene id: 7227:Dmel_CG8416
uniprot id: P48148
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Embryonic lethal. Embryos exhibit severe defects in head involution and imperfect dorsal closure. During head involution, the head structures fail to internalize resulting in holes in the dorsal anterior region of the cuticle. The disruption in the dorsal surface stretches the ventral surface, causing the cuticle to bow.
messages: Expressed in hemocytes (at protein level).
messages: Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10556060, PubMed:10323867). During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340).
messages: Interacts with capu (PubMed:10556060). Interacts (via REM repeats) with Pkn (via N-terminus) (PubMed:10323867, PubMed:17507675). Interacts (via N-terminus) with wash (via N-terminus) (PubMed:25739458).
messages: Lateral cell membrane
messages: cytoskeleton

7227:Dmel CG8721
gene id: 7227:Dmel_CG8721
uniprot id: P40807
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Expressed in adults.
messages: Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.
messages: Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

7227:Dmel CG3609
gene id: 7227:Dmel_CG3609
uniprot id: Q9VQB4
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

7227:Dmel CG32137
gene id: 7227:Dmel_CG32137
uniprot id: Q8SWR2
names: Similarity
messages: Belongs to the BICDR family.

7227:Dmel CG42256
gene id: 7227:Dmel_CG42256
uniprot id: Q9VS29
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Cell adhesion molecule.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Membrane

7227:Dmel CG10357
gene id: 7227:Dmel_CG10357
uniprot id: Q9VZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted
messages: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.

7227:Dmel CG3782
gene id: 7227:Dmel_CG3782
uniprot id: A8E702
uniprot id: Q9VMX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7227:Dmel CG33902
gene id: 7227:Dmel_CG33902
uniprot id: P02283
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).
messages: Methylation at Pro-2 increases upon heat shock.
messages: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Was reported to be phosphorylated at Ser-34. However, the paper was retracted because some data, results and conclusions in the paper are not reliable.

7227:Dmel CG9424
gene id: 7227:Dmel_CG9424
uniprot id: Q709R6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Inner nuclear membrane protein (PubMed:15035436, PubMed:24700158). May have a role in maintaining the structural integrity of the nuclear lamina (PubMed:24700158). During pupal development, plays essential and redundant functions with the other LEM domain proteins; MAN1 and Ote (PubMed:24700158). Also has a redundant but important role with Ote in larval development (PubMed:24700158).
messages: Nucleus inner membrane
messages: Uniform expression throughout development and in adults (at protein level) (PubMed:16439308). Isoform A: Expressed in larvae (PubMed:15035436). Isoform B: Lower levels of expression in larvae compared to isoform A (PubMed:15035436).
messages: Viable and fertile, with no obvious phenotype (PubMed:15035436, PubMed:24700158). In the salivary gland nuclei of third-instar larvae, there are increased deformities in the nuclear lamina with 1 to 7 abnormal O-shaped Lam-containing structures (PubMed:24700158). No significant decrease in adult survival, however double mutants with either Ote or MAN1 do not survive to the adult stage (PubMed:24700158). Double bocks and Ote mutants larvae have small brains, their imaginal disks are reduced in size or absent, and only 10% of second-instar larvae reach the pupal stage (PubMed:24700158). In bocks and MAN1 double mutants, pupal survival and larvae development is unaffected (PubMed:24700158).
messages: nucleoplasm

7227:Dmel CG12464
gene id: 7227:Dmel_CG12464
uniprot id: A1Z9G4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

7227:Dmel CG4510
gene id: 7227:Dmel_CG4510
uniprot id: Q9VDS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF6 family.
messages: Involved in a nucleolar function.
messages: nucleolus

7227:Dmel CG18608
gene id: 7227:Dmel_CG18608
uniprot id: Q7JNE1
names: Function
names: Subunit
messages: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
messages: Self-associates forming complexes of several hundred monomers.

7227:Dmel CG4880
gene id: 7227:Dmel_CG4880
uniprot id: M9PHD6
uniprot id: Q9VX97
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

7227:Dmel CG9472
gene id: 7227:Dmel_CG9472
uniprot id: Q9VVZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

7227:Dmel CG10223
gene id: 7227:Dmel_CG10223
uniprot id: P15348
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Chromosome
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:8978614). Topoisomerase II makes double-strand breaks (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:9545289). Essential during mitosis and meiosis for proper segregation of daughter chromosomes (PubMed:10751154, PubMed:14600258, PubMed:18752348, PubMed:25340780). During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I (PubMed:25340780). During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles (PubMed:18752348). May have a role in chromatin condensation and chromosome structure (PubMed:14600258, PubMed:18752348, PubMed:25340780). May be involved in X-chromosome dosage compensation, perhaps by modifying the topological state of compensated genes (PubMed:23989663). Regulates activity of the gypsy chromatin insulator complex by binding to mod(mdg4) and preventing its degradation (PubMed:21304601).
messages: Cytoplasm
messages: Detected in germline and follicle cells (at protein level). Predominantly expressed in follicle cells where expression persists throughout oogenesis (at protein level). In germline cells, expression levels decrease as cells develop and move to the posterior region of the germarium.
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Homodimer (By similarity). Interacts with mod(mdg4) (PubMed:21304601). Interacts with barr (PubMed:8978614, PubMed:11172718). Interacts with ph-p (PubMed:11172718). Interacts with mle; the interaction mediates association with the MSL dosage compensation complex (PubMed:23989663).
messages: Homozygous lethal (PubMed:21304601). Embryogenesis appears normal, probably due to maternal contribution of the protein (PubMed:21304601). However after hatching flies show a 2-3 day delay in development and most die before the third instar stage (PubMed:21304601). Conditional RNAi-mediated knockdown in the female germline does not affect fertilization but embryos fail to initiate proper mitotic divisions and do not hatch (PubMed:25340780). Embryos contain only two nuclei; a small nucleus with a centriolar spindle and a large round nucleus (PubMed:25340780). Knockdown in stage 3 oocytes often results in the heterochromatic regions of all four chromosomes failing to separate during prometaphase I and metaphase I of meiosis I (PubMed:25340780). In some instances, the anchored heterochromatic regions become stretched as the centromeres attempt to move towards the spindles poles creating long, abnormal heterochromatin structures that project from the main chromosome mass with centromeres at their tips (PubMed:25340780). Spindle assembly is not affected (PubMed:25340780). Spindles are bipolar although one or both sides of the spindle are elongated due to the abnormal heterochromatin projections (PubMed:25340780).
messages: Nucleus
messages: Phosphorylated (PubMed:1328202, PubMed:8383533, PubMed:10751154). Phosphorylation by casein kinase II enhances ATPase activity (PubMed:1328202).

7227:Dmel CG8023
gene id: 7227:Dmel_CG8023
uniprot id: Q9VSG1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7227:Dmel CG3303
gene id: 7227:Dmel_CG3303
uniprot id: Q9VF14
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

7227:Dmel CG9739
gene id: 7227:Dmel_CG9739
uniprot id: B7Z072
uniprot id: M9PFW3
uniprot id: Q9VVX3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Expression starts at stage 6 in all cells between 15 and 70 per cent of egg length, including the invaginating cells of the ventral furrow. Stripe pattern is emerging by early stage 8. From stage 9 and continuing throughout embryogenesis, expression is seen in the developing CNS. At stage 10, expressed in 15 stripes in the presumptive head and trunk regions, in the posterior midgut primordium, in a subset of cells of anterior midgut invagination and in the procephalic lobe. At stage 12, expression declines in epidermis and increases in the midgut and visceral mesoderm. At stage 17, only expressed in the CNS, hindgut and dorsal vessel.
messages: Interacts with ATP6AP2.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
messages: The FZ domain is involved in binding with Wnt ligands.

7227:Dmel CG33847
gene id: 7227:Dmel_CG33847
uniprot id: P84051
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7227:Dmel CG13388
gene id: 7227:Dmel_CG13388
uniprot id: Q9VLL3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By ethanol.
messages: Cell membrane
messages: Detected in the brain in both neurons and glia (including perineurial glia); specifically in the neuronal nuclei in the cortex and synaptic neuropil (at protein level) (PubMed:29444420). Detected in germline cells, somatic follicle cells and outer rim of the ring canals during oogenesis (at protein level) (PubMed:12223401). Isoform A: Detected in the adult (at protein level) (PubMed:10480936). Isoform B: Detected in the adult with higher levels in the head (at protein level) (PubMed:10480936).
messages: Homodimer (PubMed:10480937). Interacts with Cam; interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937). Interacts with N/Notch; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414). Interacts with Pka-R2 (PubMed:10480936, PubMed:10480937). Binds to F-actin; interaction is independent of myristoylation, but is inhibited by Akap200 phosphorylation and Cam binding (PubMed:10480937). Isoform B: Does not bind to Pka-R2 (PubMed:10480936).
messages: Isoform A: Detected in all stages of development, with higher levels in the pupae (at protein level) (PubMed:10480936). Isoform B: Detected in all stages of development (at protein level) (PubMed:10480936).
messages: Myristoylated; myristoylation promotes accumulation at the cell periphery.
messages: Phosphorylated; phosphorylation prevents binding to F-actin and Cam.
messages: Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium (PubMed:10480936, PubMed:10480937, PubMed:12223401). Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling (PubMed:12223401). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia (PubMed:29444420). In specific tissues such as eye and thorax, promotes N/Notch protein stability by inhibiting Cbl-mediated ubiquitination and lysosomal degradation pathway of N/Notch in a PKA-independent way (PubMed:29309414). In the circadian brain neurons evening cells (E-cells), might have a role in circadian pacemaker synchronization by playing a redundant role in signaling downstream of the G protein-couple receptor Pdfr (PubMed:23929551).
messages: Viable (PubMed:12223401, PubMed:29309414). Results in extra notal macrochaetae often accompanied by a socket cell (PubMed:12223401). In the eye, results in decreased N/Notch protein levels and ommatidia defects (PubMed:29309414). In all imaginal disks at early larval stages, results in supernumerary scutellar bristles and loss or mispositioned microchaetae (PubMed:29309414). In the wings, results in a blistered phenotype (PubMed:29309414). Females have egg chambers with multinucleate cells with ring canal remnants (PubMed:12223401). RNAi-mediated knockdown in glia or perineurial glia reduces ethanol tolerance and locomotor sensitization possibly by limiting ethanol-induced membrane topology changes; does not affect perineurial morphology; does not affect glia-mediated blood-brain barrier permeability (PubMed:29444420). RNAi-mediated knockdown in neurons does not alter ethanol sedation sensitivity or tolerance (PubMed:29444420). RNAi-mediated knockdown in the pacemaker dorsal lateral neurons (LNDs) results in reduced pigment-dispersing factor receptor (Pdfr)-mediated response in the circadian brain neuron evening cells (E-cells) (PubMed:23929551).
messages: cytoskeleton
messages: cytosol

7227:Dmel CG6608
gene id: 7227:Dmel_CG6608
uniprot id: Q7K0L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7227:Dmel CG2713
gene id: 7227:Dmel_CG2713
uniprot id: A0A0S0X8K7
uniprot id: Q9W4V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

7227:Dmel CG3569
gene id: 7227:Dmel_CG3569
uniprot id: Q9W1P8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
messages: Cell membrane
messages: Expressed in olfactory sensory neurons in the antenna.
messages: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
messages: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Also plays a role in the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
messages: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

7227:Dmel CG10186
gene id: 7227:Dmel_CG10186
uniprot id: B7YZX0
uniprot id: Q058W1
uniprot id: Q8INW2
uniprot id: Q9VIU9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG7459
gene id: 7227:Dmel_CG7459
uniprot id: Q9VHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

7227:Dmel CG9720
gene id: 7227:Dmel_CG9720
uniprot id: Q9VA61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7227:Dmel CG31322
gene id: 7227:Dmel_CG31322
uniprot id: Q9VFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

7227:Dmel CG4082
gene id: 7227:Dmel_CG4082
uniprot id: Q9VGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable).
messages: Nucleus
messages: cytosol

7227:Dmel CG4749
gene id: 7227:Dmel_CG4749
uniprot id: Q9VPX3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7227:Dmel CG3178
gene id: 7227:Dmel_CG3178
uniprot id: B7YZZ9
uniprot id: P27864
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Expressed throughout development, with slightly higher levels of expression in 0-12 hour embryos and adult females.
messages: Interacts with the zeta DNA polymerase complex; interacts (via the N-terminus) with the accessory subunit PolZ2/Rev7 and also interacts with the catalytic component PolZ1, however the interaction with PolZ1 is likely via PolZ2.
messages: Nucleus
messages: Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair (PubMed:1713691, PubMed:16507570). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16507570). Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity). Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:16507570). Has apurinic endonuclease and double-stranded DNA 3'-exonuclease activities and carries out single-stranded DNA renaturation in a Mg(2+)-dependent manner (PubMed:1713691, PubMed:8918793). Activity is more efficient in purine-rich regions of dsDNA than in pyrimidine-rich regions (PubMed:8918793).
messages: Probably binds two magnesium or manganese ions per subunit.

7227:Dmel CG2075
gene id: 7227:Dmel_CG2075
uniprot id: Q9VZW3
names: Similarity
messages: Belongs to the lin-9 family.