717231:FLEXSI RS00945
gene id: 717231:FLEXSI_RS00945
uniprot id: F8E7P0
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10510
gene id: 717231:FLEXSI_RS10510
uniprot id: F8E558
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

717231:FLEXSI RS11385
gene id: 717231:FLEXSI_RS11385
uniprot id: F8E689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS05380
gene id: 717231:FLEXSI_RS05380
uniprot id: F8E614
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

717231:FLEXSI RS02885
gene id: 717231:FLEXSI_RS02885
uniprot id: F8E9S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

717231:FLEXSI RS07320
gene id: 717231:FLEXSI_RS07320
uniprot id: F8E894
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS11880
gene id: 717231:FLEXSI_RS11880
uniprot id: F8E6Q2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

717231:FLEXSI RS05355
gene id: 717231:FLEXSI_RS05355
uniprot id: F8E609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

717231:FLEXSI RS04590
gene id: 717231:FLEXSI_RS04590
uniprot id: F8E576
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

717231:FLEXSI RS07840
gene id: 717231:FLEXSI_RS07840
uniprot id: F8E8S1
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

717231:FLEXSI RS00925
gene id: 717231:FLEXSI_RS00925
uniprot id: F8E7N6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS02445
gene id: 717231:FLEXSI_RS02445
uniprot id: F8E9C6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

717231:FLEXSI RS07300
gene id: 717231:FLEXSI_RS07300
uniprot id: F8E890
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

717231:FLEXSI RS05610
gene id: 717231:FLEXSI_RS05610
uniprot id: F8E659
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

717231:FLEXSI RS05925
gene id: 717231:FLEXSI_RS05925
uniprot id: F8E6J0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

717231:FLEXSI RS03515
gene id: 717231:FLEXSI_RS03515
uniprot id: F8E424
names: Similarity
messages: Belongs to the DEAD box helicase family.

717231:FLEXSI RS04560
gene id: 717231:FLEXSI_RS04560
uniprot id: F8E4Z6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

717231:FLEXSI RS06190
gene id: 717231:FLEXSI_RS06190
uniprot id: F8E713
names: Similarity
messages: Belongs to the GSP E family.

717231:FLEXSI RS08720
gene id: 717231:FLEXSI_RS08720
uniprot id: F8E9U9
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

717231:FLEXSI RS06610
gene id: 717231:FLEXSI_RS06610
uniprot id: F8E7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

717231:FLEXSI RS01020
gene id: 717231:FLEXSI_RS01020
uniprot id: F8E7Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS03640
gene id: 717231:FLEXSI_RS03640
uniprot id: F8E448
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

717231:FLEXSI RS06680
gene id: 717231:FLEXSI_RS06680
uniprot id: F8E7I0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

717231:FLEXSI RS01080
gene id: 717231:FLEXSI_RS01080
uniprot id: F8E7R7
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS06545
gene id: 717231:FLEXSI_RS06545
uniprot id: F8E7F5
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07590
gene id: 717231:FLEXSI_RS07590
uniprot id: F8E8M1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06395
gene id: 717231:FLEXSI_RS06395
uniprot id: F8E752
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

717231:FLEXSI RS01260
gene id: 717231:FLEXSI_RS01260
uniprot id: F8E825
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06080
gene id: 717231:FLEXSI_RS06080
uniprot id: F8E6L7
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

717231:FLEXSI RS05295
gene id: 717231:FLEXSI_RS05295
uniprot id: F8E5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

717231:FLEXSI RS04445
gene id: 717231:FLEXSI_RS04445
uniprot id: F8E4X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

717231:FLEXSI RS05655
gene id: 717231:FLEXSI_RS05655
uniprot id: F8E668
names: Similarity
messages: Belongs to the aspartokinase family.

717231:FLEXSI RS08495
gene id: 717231:FLEXSI_RS08495
uniprot id: F8E9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

717231:FLEXSI RS09530
gene id: 717231:FLEXSI_RS09530
uniprot id: F8E484
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07270
gene id: 717231:FLEXSI_RS07270
uniprot id: F8E884
names: Similarity
messages: Belongs to the Fur family.

717231:FLEXSI RS08590
gene id: 717231:FLEXSI_RS08590
uniprot id: F8E9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

717231:FLEXSI RS09675
gene id: 717231:FLEXSI_RS09675
uniprot id: F8E4B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

717231:FLEXSI RS02435
gene id: 717231:FLEXSI_RS02435
uniprot id: F8E9C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

717231:FLEXSI RS04340
gene id: 717231:FLEXSI_RS04340
uniprot id: F8E4V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

717231:FLEXSI RS00035
gene id: 717231:FLEXSI_RS00035
uniprot id: F8E6E9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS09135
gene id: 717231:FLEXSI_RS09135
uniprot id: F8E3T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS00280
gene id: 717231:FLEXSI_RS00280
uniprot id: F8E6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

717231:FLEXSI RS01935
gene id: 717231:FLEXSI_RS01935
uniprot id: F8E8V8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

717231:FLEXSI RS02010
gene id: 717231:FLEXSI_RS02010
uniprot id: F8E8X4
names: Similarity
messages: Belongs to the DNA photolyase family.

717231:FLEXSI RS04880
gene id: 717231:FLEXSI_RS04880
uniprot id: F8E5D0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

717231:FLEXSI RS03340
gene id: 717231:FLEXSI_RS03340
uniprot id: F8E3R9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

717231:FLEXSI RS06005
gene id: 717231:FLEXSI_RS06005
uniprot id: F8E6K2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

717231:FLEXSI RS05640
gene id: 717231:FLEXSI_RS05640
uniprot id: F8E665
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

717231:FLEXSI RS00010
gene id: 717231:FLEXSI_RS00010
uniprot id: F8E6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

717231:FLEXSI RS04810
gene id: 717231:FLEXSI_RS04810
uniprot id: F8E5B6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

717231:FLEXSI RS05110
gene id: 717231:FLEXSI_RS05110
uniprot id: F8E5P0
names: Similarity
messages: Belongs to the UPF0434 family.

717231:FLEXSI RS06025
gene id: 717231:FLEXSI_RS06025
uniprot id: F8E6K6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

717231:FLEXSI RS11085
gene id: 717231:FLEXSI_RS11085
uniprot id: F8E5V5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

717231:FLEXSI RS03575
gene id: 717231:FLEXSI_RS03575
uniprot id: F8E437
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

717231:FLEXSI RS03195
gene id: 717231:FLEXSI_RS03195
uniprot id: F8E3P1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

717231:FLEXSI RS11200
gene id: 717231:FLEXSI_RS11200
uniprot id: F8E5X8
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

717231:FLEXSI RS06255
gene id: 717231:FLEXSI_RS06255
uniprot id: F8E726
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07345
gene id: 717231:FLEXSI_RS07345
uniprot id: F8E899
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS11205
gene id: 717231:FLEXSI_RS11205
uniprot id: F8E5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

717231:FLEXSI RS10815
gene id: 717231:FLEXSI_RS10815
uniprot id: F8E5I6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

717231:FLEXSI RS01985
gene id: 717231:FLEXSI_RS01985
uniprot id: F8E8W9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03295
gene id: 717231:FLEXSI_RS03295
uniprot id: F8E3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

717231:FLEXSI RS06340
gene id: 717231:FLEXSI_RS06340
uniprot id: F8E743
names: Similarity
messages: Belongs to the ABC transporter superfamily.

717231:FLEXSI RS11710
gene id: 717231:FLEXSI_RS11710
uniprot id: F8E6M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Membrane

717231:FLEXSI RS05935
gene id: 717231:FLEXSI_RS05935
uniprot id: F8E6J2
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03285
gene id: 717231:FLEXSI_RS03285
uniprot id: F8E3Q8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS02425
gene id: 717231:FLEXSI_RS02425
uniprot id: F8E9C2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

717231:FLEXSI RS05440
gene id: 717231:FLEXSI_RS05440
uniprot id: F8E627
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

717231:FLEXSI RS05390
gene id: 717231:FLEXSI_RS05390
uniprot id: F8E616
names: Similarity
messages: Belongs to the peptidase S24 family.

717231:FLEXSI RS08745
gene id: 717231:FLEXSI_RS08745
uniprot id: F8E9V4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

717231:FLEXSI RS00380
gene id: 717231:FLEXSI_RS00380
uniprot id: F8E6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

717231:FLEXSI RS01460
gene id: 717231:FLEXSI_RS01460
uniprot id: F8E864
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

717231:FLEXSI RS08735
gene id: 717231:FLEXSI_RS08735
uniprot id: F8E9V2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

717231:FLEXSI RS04160
gene id: 717231:FLEXSI_RS04160
uniprot id: F8E4K5
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

717231:FLEXSI RS00495
gene id: 717231:FLEXSI_RS00495
uniprot id: F8E781
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS09670
gene id: 717231:FLEXSI_RS09670
uniprot id: F8E4B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

717231:FLEXSI RS03525
gene id: 717231:FLEXSI_RS03525
uniprot id: F8E426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

717231:FLEXSI RS02620
gene id: 717231:FLEXSI_RS02620
uniprot id: F8E9G0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

717231:FLEXSI RS03405
gene id: 717231:FLEXSI_RS03405
uniprot id: F8E402
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

717231:FLEXSI RS09140
gene id: 717231:FLEXSI_RS09140
uniprot id: F8E3T6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

717231:FLEXSI RS07240
gene id: 717231:FLEXSI_RS07240
uniprot id: F8E878
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS02895
gene id: 717231:FLEXSI_RS02895
uniprot id: F8E9S6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

717231:FLEXSI RS08425
gene id: 717231:FLEXSI_RS08425
uniprot id: F8E9H4
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

717231:FLEXSI RS09865
gene id: 717231:FLEXSI_RS09865
uniprot id: F8E4L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

717231:FLEXSI RS00030
gene id: 717231:FLEXSI_RS00030
uniprot id: F8E6E8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS05285
gene id: 717231:FLEXSI_RS05285
uniprot id: F8E5S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

717231:FLEXSI RS02235
gene id: 717231:FLEXSI_RS02235
uniprot id: F8E913
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

717231:FLEXSI RS11240
gene id: 717231:FLEXSI_RS11240
uniprot id: F8E5Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS01445
gene id: 717231:FLEXSI_RS01445
uniprot id: F8E859
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

717231:FLEXSI RS08580
gene id: 717231:FLEXSI_RS08580
uniprot id: F8E9K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

717231:FLEXSI RS10985
gene id: 717231:FLEXSI_RS10985
uniprot id: F8E5T4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

717231:FLEXSI RS05340
gene id: 717231:FLEXSI_RS05340
uniprot id: F8E605
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

717231:FLEXSI RS00585
gene id: 717231:FLEXSI_RS00585
uniprot id: F8E799
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

717231:FLEXSI RS05185
gene id: 717231:FLEXSI_RS05185
uniprot id: F8E5Q3
names: Similarity
messages: Belongs to the methyltransferase superfamily. PrmA family.

717231:FLEXSI RS07335
gene id: 717231:FLEXSI_RS07335
uniprot id: F8E897
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS00645
gene id: 717231:FLEXSI_RS00645
uniprot id: F8E7B1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07210
gene id: 717231:FLEXSI_RS07210
uniprot id: F8E872
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

717231:FLEXSI RS10040
gene id: 717231:FLEXSI_RS10040
uniprot id: F8E4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

717231:FLEXSI RS09250
gene id: 717231:FLEXSI_RS09250
uniprot id: F8E3V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

717231:FLEXSI RS00875
gene id: 717231:FLEXSI_RS00875
uniprot id: F8E7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

717231:FLEXSI RS09860
gene id: 717231:FLEXSI_RS09860
uniprot id: F8E4L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS01060
gene id: 717231:FLEXSI_RS01060
uniprot id: F8E7R3
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS08500
gene id: 717231:FLEXSI_RS08500
uniprot id: F8E9I9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

717231:FLEXSI RS07340
gene id: 717231:FLEXSI_RS07340
uniprot id: F8E898
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS11295
gene id: 717231:FLEXSI_RS11295
uniprot id: F8E5Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

717231:FLEXSI RS04995
gene id: 717231:FLEXSI_RS04995
uniprot id: F8E5L8
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS09425
gene id: 717231:FLEXSI_RS09425
uniprot id: F8E3Z3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

717231:FLEXSI RS03925
gene id: 717231:FLEXSI_RS03925
uniprot id: F8E4G6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03890
gene id: 717231:FLEXSI_RS03890
uniprot id: F8E4F9
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

717231:FLEXSI RS09945
gene id: 717231:FLEXSI_RS09945
uniprot id: F8E4N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

717231:FLEXSI RS03300
gene id: 717231:FLEXSI_RS03300
uniprot id: F8E3R1
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

717231:FLEXSI RS07205
gene id: 717231:FLEXSI_RS07205
uniprot id: F8E800
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

717231:FLEXSI RS03595
gene id: 717231:FLEXSI_RS03595
uniprot id: F8E441
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

717231:FLEXSI RS04595
gene id: 717231:FLEXSI_RS04595
uniprot id: F8E577
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

717231:FLEXSI RS06835
gene id: 717231:FLEXSI_RS06835
uniprot id: F8E7L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

717231:FLEXSI RS11405
gene id: 717231:FLEXSI_RS11405
uniprot id: F8E692
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

717231:FLEXSI RS01155
gene id: 717231:FLEXSI_RS01155
uniprot id: F8E803
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

717231:FLEXSI RS05265
gene id: 717231:FLEXSI_RS05265
uniprot id: F8E5R9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

717231:FLEXSI RS09915
gene id: 717231:FLEXSI_RS09915
uniprot id: F8E4M5
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

717231:FLEXSI RS11250
gene id: 717231:FLEXSI_RS11250
uniprot id: F8E5Y8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

717231:FLEXSI RS10020
gene id: 717231:FLEXSI_RS10020
uniprot id: F8E4P6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS05665
gene id: 717231:FLEXSI_RS05665
uniprot id: F8E670
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

717231:FLEXSI RS00245
gene id: 717231:FLEXSI_RS00245
uniprot id: F8E6W0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

717231:FLEXSI RS06110
gene id: 717231:FLEXSI_RS06110
uniprot id: F8E6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS10320
gene id: 717231:FLEXSI_RS10320
uniprot id: F8E523
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

717231:FLEXSI RS09340
gene id: 717231:FLEXSI_RS09340
uniprot id: F8E3X6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

717231:FLEXSI RS02270
gene id: 717231:FLEXSI_RS02270
uniprot id: F8E991
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

717231:FLEXSI RS07495
gene id: 717231:FLEXSI_RS07495
uniprot id: F8E8C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

717231:FLEXSI RS07865
gene id: 717231:FLEXSI_RS07865
uniprot id: F8E8S6
names: Similarity
messages: Belongs to the citrate synthase family.

717231:FLEXSI RS02995
gene id: 717231:FLEXSI_RS02995
uniprot id: F8E9U6
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS05680
gene id: 717231:FLEXSI_RS05680
uniprot id: F8E673
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

717231:FLEXSI RS03445
gene id: 717231:FLEXSI_RS03445
uniprot id: F8E410
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

717231:FLEXSI RS05820
gene id: 717231:FLEXSI_RS05820
uniprot id: F8E6H0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

717231:FLEXSI RS08000
gene id: 717231:FLEXSI_RS08000
uniprot id: F8E924
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07330
gene id: 717231:FLEXSI_RS07330
uniprot id: F8E896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS12920
gene id: 717231:FLEXSI_RS12920
uniprot id: F8E407
names: Similarity
messages: Belongs to the class-I fumarase family.

717231:FLEXSI RS04530
gene id: 717231:FLEXSI_RS04530
uniprot id: F8E4Z0
names: Similarity
messages: Belongs to the thioredoxin family.

717231:FLEXSI RS11015
gene id: 717231:FLEXSI_RS11015
uniprot id: F8E5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

717231:FLEXSI RS10960
gene id: 717231:FLEXSI_RS10960
uniprot id: F8E5K7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

717231:FLEXSI RS03275
gene id: 717231:FLEXSI_RS03275
uniprot id: F8E3Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

717231:FLEXSI RS08455
gene id: 717231:FLEXSI_RS08455
uniprot id: F8E9I0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

717231:FLEXSI RS06555
gene id: 717231:FLEXSI_RS06555
uniprot id: F8E7F7
names: Similarity
messages: Belongs to the leucine-binding protein family.

717231:FLEXSI RS00480
gene id: 717231:FLEXSI_RS00480
uniprot id: F8E778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

717231:FLEXSI RS02280
gene id: 717231:FLEXSI_RS02280
uniprot id: F8E993
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

717231:FLEXSI RS11690
gene id: 717231:FLEXSI_RS11690
uniprot id: F8E6E1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

717231:FLEXSI RS02430
gene id: 717231:FLEXSI_RS02430
uniprot id: F8E9C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

717231:FLEXSI RS01615
gene id: 717231:FLEXSI_RS01615
uniprot id: F8E8G9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

717231:FLEXSI RS03045
gene id: 717231:FLEXSI_RS03045
uniprot id: F8E3L6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

717231:FLEXSI RS09360
gene id: 717231:FLEXSI_RS09360
uniprot id: F8E3Y0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

717231:FLEXSI RS07260
gene id: 717231:FLEXSI_RS07260
uniprot id: F8E882
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

717231:FLEXSI RS03745
gene id: 717231:FLEXSI_RS03745
uniprot id: F8E466
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11005
gene id: 717231:FLEXSI_RS11005
uniprot id: F8E5T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

717231:FLEXSI RS05865
gene id: 717231:FLEXSI_RS05865
uniprot id: F8E6H8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08760
gene id: 717231:FLEXSI_RS08760
uniprot id: F8E9V7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS04065
gene id: 717231:FLEXSI_RS04065
uniprot id: F8E4J0
names: Similarity
messages: Belongs to the leucine-binding protein family.

717231:FLEXSI RS01905
gene id: 717231:FLEXSI_RS01905
uniprot id: F8E8V2
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

717231:FLEXSI RS01390
gene id: 717231:FLEXSI_RS01390
uniprot id: F8E848
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

717231:FLEXSI RS11145
gene id: 717231:FLEXSI_RS11145
uniprot id: F8E5W7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

717231:FLEXSI RS03565
gene id: 717231:FLEXSI_RS03565
uniprot id: F8E435
names: Similarity
messages: Belongs to the glutamine synthetase family.

717231:FLEXSI RS10465
gene id: 717231:FLEXSI_RS10465
uniprot id: F8E549
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

717231:FLEXSI RS00670
gene id: 717231:FLEXSI_RS00670
uniprot id: F8E7B6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

717231:FLEXSI RS08140
gene id: 717231:FLEXSI_RS08140
uniprot id: F8E953
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

717231:FLEXSI RS11410
gene id: 717231:FLEXSI_RS11410
uniprot id: F8E693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

717231:FLEXSI RS10680
gene id: 717231:FLEXSI_RS10680
uniprot id: F8E5F8
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

717231:FLEXSI RS09840
gene id: 717231:FLEXSI_RS09840
uniprot id: F8E4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS01385
gene id: 717231:FLEXSI_RS01385
uniprot id: F8E847
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS00510
gene id: 717231:FLEXSI_RS00510
uniprot id: F8E784
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

717231:FLEXSI RS02020
gene id: 717231:FLEXSI_RS02020
uniprot id: F8E8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

717231:FLEXSI RS10915
gene id: 717231:FLEXSI_RS10915
uniprot id: F8E5J9
names: Similarity
messages: Belongs to the CinA family.

717231:FLEXSI RS09280
gene id: 717231:FLEXSI_RS09280
uniprot id: F8E3W4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

717231:FLEXSI RS10965
gene id: 717231:FLEXSI_RS10965
uniprot id: F8E5K8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS07460
gene id: 717231:FLEXSI_RS07460
uniprot id: F8E8C2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

717231:FLEXSI RS03675
gene id: 717231:FLEXSI_RS03675
uniprot id: F8E4C4
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

717231:FLEXSI RS02910
gene id: 717231:FLEXSI_RS02910
uniprot id: F8E9S9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

717231:FLEXSI RS03600
gene id: 717231:FLEXSI_RS03600
uniprot id: F8E442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

717231:FLEXSI RS02250
gene id: 717231:FLEXSI_RS02250
uniprot id: F8E915
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

717231:FLEXSI RS01595
gene id: 717231:FLEXSI_RS01595
uniprot id: F8E8G5
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

717231:FLEXSI RS11215
gene id: 717231:FLEXSI_RS11215
uniprot id: F8E5Y1
names: Similarity
messages: Belongs to the glutamate synthase family.

717231:FLEXSI RS07670
gene id: 717231:FLEXSI_RS07670
uniprot id: F8E8N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

717231:FLEXSI RS02695
gene id: 717231:FLEXSI_RS02695
uniprot id: F8E9P1
names: Similarity
messages: Belongs to the ribF family.

717231:FLEXSI RS03050
gene id: 717231:FLEXSI_RS03050
uniprot id: F8E3L7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

717231:FLEXSI RS11190
gene id: 717231:FLEXSI_RS11190
uniprot id: F8E5X6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

717231:FLEXSI RS08255
gene id: 717231:FLEXSI_RS08255
uniprot id: F8E973
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

717231:FLEXSI RS00430
gene id: 717231:FLEXSI_RS00430
uniprot id: F8E767
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

717231:FLEXSI RS00435
gene id: 717231:FLEXSI_RS00435
uniprot id: F8E768
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

717231:FLEXSI RS03190
gene id: 717231:FLEXSI_RS03190
uniprot id: F8E3P0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

717231:FLEXSI RS08545
gene id: 717231:FLEXSI_RS08545
uniprot id: F8E9J8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07600
gene id: 717231:FLEXSI_RS07600
uniprot id: F8E8M3
names: Subcellular Location Annotation
messages: Mitochondrion

717231:FLEXSI RS06055
gene id: 717231:FLEXSI_RS06055
uniprot id: F8E6L2
names: Similarity
messages: Belongs to the leucine-binding protein family.

717231:FLEXSI RS01195
gene id: 717231:FLEXSI_RS01195
uniprot id: F8E812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS09625
gene id: 717231:FLEXSI_RS09625
uniprot id: F8E4A1
names: Similarity
messages: Belongs to the MEMO1 family.

717231:FLEXSI RS00285
gene id: 717231:FLEXSI_RS00285
uniprot id: F8E6W8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

717231:FLEXSI RS06795
gene id: 717231:FLEXSI_RS06795
uniprot id: F8E7K4
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

717231:FLEXSI RS04605
gene id: 717231:FLEXSI_RS04605
uniprot id: F8E579
names: Similarity
messages: Belongs to the ycf81 family.

717231:FLEXSI RS01770
gene id: 717231:FLEXSI_RS01770
uniprot id: F8E8J8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06195
gene id: 717231:FLEXSI_RS06195
uniprot id: F8E714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

717231:FLEXSI RS07525
gene id: 717231:FLEXSI_RS07525
uniprot id: F8E8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

717231:FLEXSI RS07440
gene id: 717231:FLEXSI_RS07440
uniprot id: F8E8B8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS06575
gene id: 717231:FLEXSI_RS06575
uniprot id: F8E7G1
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS03020
gene id: 717231:FLEXSI_RS03020
uniprot id: F8E3L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08550
gene id: 717231:FLEXSI_RS08550
uniprot id: F8E9J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

717231:FLEXSI RS11195
gene id: 717231:FLEXSI_RS11195
uniprot id: F8E5X7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

717231:FLEXSI RS05695
gene id: 717231:FLEXSI_RS05695
uniprot id: F8E676
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

717231:FLEXSI RS09355
gene id: 717231:FLEXSI_RS09355
uniprot id: F8E3X9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

717231:FLEXSI RS11455
gene id: 717231:FLEXSI_RS11455
uniprot id: F8E6A0
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

717231:FLEXSI RS10390
gene id: 717231:FLEXSI_RS10390
uniprot id: F8E535
names: Similarity
messages: Belongs to the CFA/CMAS family.

717231:FLEXSI RS04940
gene id: 717231:FLEXSI_RS04940
uniprot id: F8E5E2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

717231:FLEXSI RS05095
gene id: 717231:FLEXSI_RS05095
uniprot id: F8E5N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

717231:FLEXSI RS08345
gene id: 717231:FLEXSI_RS08345
uniprot id: F8E988
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

717231:FLEXSI RS06565
gene id: 717231:FLEXSI_RS06565
uniprot id: F8E7F9
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

717231:FLEXSI RS10575
gene id: 717231:FLEXSI_RS10575
uniprot id: F8E570
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

717231:FLEXSI RS03490
gene id: 717231:FLEXSI_RS03490
uniprot id: F8E419
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

717231:FLEXSI RS07485
gene id: 717231:FLEXSI_RS07485
uniprot id: F8E8C7
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

717231:FLEXSI RS11920
gene id: 717231:FLEXSI_RS11920
uniprot id: F8E6R0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

717231:FLEXSI RS09290
gene id: 717231:FLEXSI_RS09290
uniprot id: F8E3W6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

717231:FLEXSI RS03125
gene id: 717231:FLEXSI_RS03125
uniprot id: F8E3M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

717231:FLEXSI RS05470
gene id: 717231:FLEXSI_RS05470
uniprot id: F8E633
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

717231:FLEXSI RS10315
gene id: 717231:FLEXSI_RS10315
uniprot id: F8E522
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

717231:FLEXSI RS09180
gene id: 717231:FLEXSI_RS09180
uniprot id: F8E3U4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

717231:FLEXSI RS11745
gene id: 717231:FLEXSI_RS11745
uniprot id: F8E6M8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

717231:FLEXSI RS10940
gene id: 717231:FLEXSI_RS10940
uniprot id: F8E5K4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

717231:FLEXSI RS04610
gene id: 717231:FLEXSI_RS04610
uniprot id: F8E580
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

717231:FLEXSI RS02785
gene id: 717231:FLEXSI_RS02785
uniprot id: F8E9Q6
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

717231:FLEXSI RS10925
gene id: 717231:FLEXSI_RS10925
uniprot id: F8E5K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

717231:FLEXSI RS02145
gene id: 717231:FLEXSI_RS02145
uniprot id: F8E901
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

717231:FLEXSI RS09175
gene id: 717231:FLEXSI_RS09175
uniprot id: F8E3U3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

717231:FLEXSI RS00565
gene id: 717231:FLEXSI_RS00565
uniprot id: F8E795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

717231:FLEXSI RS10745
gene id: 717231:FLEXSI_RS10745
uniprot id: F8E5H1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

717231:FLEXSI RS01870
gene id: 717231:FLEXSI_RS01870
uniprot id: F8E8L9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

717231:FLEXSI RS03875
gene id: 717231:FLEXSI_RS03875
uniprot id: F8E4F6
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

717231:FLEXSI RS02570
gene id: 717231:FLEXSI_RS02570
uniprot id: F8E9F1
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

717231:FLEXSI RS06250
gene id: 717231:FLEXSI_RS06250
uniprot id: F8E725
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS04315
gene id: 717231:FLEXSI_RS04315
uniprot id: F8E4U9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

717231:FLEXSI RS02685
gene id: 717231:FLEXSI_RS02685
uniprot id: F8E9N9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

717231:FLEXSI RS01465
gene id: 717231:FLEXSI_RS01465
uniprot id: F8E865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS12135
gene id: 717231:FLEXSI_RS12135
uniprot id: F8E5S8
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

717231:FLEXSI RS04925
gene id: 717231:FLEXSI_RS04925
uniprot id: F8E5D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

717231:FLEXSI RS06130
gene id: 717231:FLEXSI_RS06130
uniprot id: F8E701
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

717231:FLEXSI RS01200
gene id: 717231:FLEXSI_RS01200
uniprot id: F8E813
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

717231:FLEXSI RS00795
gene id: 717231:FLEXSI_RS00795
uniprot id: F8E7L1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

717231:FLEXSI RS06450
gene id: 717231:FLEXSI_RS06450
uniprot id: F8E762
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

717231:FLEXSI RS09210
gene id: 717231:FLEXSI_RS09210
uniprot id: F8E3V0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

717231:FLEXSI RS08360
gene id: 717231:FLEXSI_RS08360
uniprot id: F8E9G4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

717231:FLEXSI RS09725
gene id: 717231:FLEXSI_RS09725
uniprot id: F8E4C1
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

717231:FLEXSI RS07120
gene id: 717231:FLEXSI_RS07120
uniprot id: F8E7Y3
names: Similarity
messages: Belongs to the AOR/FOR family.

717231:FLEXSI RS07035
gene id: 717231:FLEXSI_RS07035
uniprot id: F8E7W8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07930
gene id: 717231:FLEXSI_RS07930
uniprot id: F8E8T9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

717231:FLEXSI RS11140
gene id: 717231:FLEXSI_RS11140
uniprot id: F8E5W6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

717231:FLEXSI RS10280
gene id: 717231:FLEXSI_RS10280
uniprot id: F8E515
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

717231:FLEXSI RS00170
gene id: 717231:FLEXSI_RS00170
uniprot id: F8E6U6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

717231:FLEXSI RS11100
gene id: 717231:FLEXSI_RS11100
uniprot id: F8E5V8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09255
gene id: 717231:FLEXSI_RS09255
uniprot id: F8E3V9
names: Similarity
messages: Belongs to the peptidase M24B family.

717231:FLEXSI RS00005
gene id: 717231:FLEXSI_RS00005
uniprot id: F8E6E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

717231:FLEXSI RS05785
gene id: 717231:FLEXSI_RS05785
uniprot id: F8E6G3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

717231:FLEXSI RS04860
gene id: 717231:FLEXSI_RS04860
uniprot id: F8E5C6
names: Similarity
messages: Belongs to the UPF0751 family.

717231:FLEXSI RS07505
gene id: 717231:FLEXSI_RS07505
uniprot id: F8E8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

717231:FLEXSI RS01535
gene id: 717231:FLEXSI_RS01535
uniprot id: F8E8F3
names: Function
names: Similarity
names: Subunit
messages: APS kinase catalyzes the synthesis of activated sulfate.
messages: Belongs to the APS kinase family.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Catalyzes the synthesis of activated sulfate.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

717231:FLEXSI RS11930
gene id: 717231:FLEXSI_RS11930
uniprot id: F8E6R2
names: Similarity
messages: Belongs to the P(II) protein family.

717231:FLEXSI RS12070
gene id: 717231:FLEXSI_RS12070
uniprot id: F8E4F0
names: Subcellular Location Annotation
messages: Cell inner membrane

717231:FLEXSI RS08805
gene id: 717231:FLEXSI_RS08805
uniprot id: F8E9W4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

717231:FLEXSI RS00520
gene id: 717231:FLEXSI_RS00520
uniprot id: F8E786
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

717231:FLEXSI RS03805
gene id: 717231:FLEXSI_RS03805
uniprot id: F8E4E5
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

717231:FLEXSI RS00270
gene id: 717231:FLEXSI_RS00270
uniprot id: F8E6W5
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

717231:FLEXSI RS04855
gene id: 717231:FLEXSI_RS04855
uniprot id: F8E5C5
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

717231:FLEXSI RS07305
gene id: 717231:FLEXSI_RS07305
uniprot id: F8E891
names: Similarity
messages: Belongs to the LacAB/RpiB family.

717231:FLEXSI RS04490
gene id: 717231:FLEXSI_RS04490
uniprot id: F8E4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

717231:FLEXSI RS02515
gene id: 717231:FLEXSI_RS02515
uniprot id: F8E9E0
names: Similarity
messages: Belongs to the HupF/HypC family.

717231:FLEXSI RS11095
gene id: 717231:FLEXSI_RS11095
uniprot id: F8E5V7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00365
gene id: 717231:FLEXSI_RS00365
uniprot id: F8E6Y3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

717231:FLEXSI RS00070
gene id: 717231:FLEXSI_RS00070
uniprot id: F8E6S6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

717231:FLEXSI RS02700
gene id: 717231:FLEXSI_RS02700
uniprot id: F8E9P2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

717231:FLEXSI RS12025
gene id: 717231:FLEXSI_RS12025
uniprot id: F8E9T9
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

717231:FLEXSI RS00755
gene id: 717231:FLEXSI_RS00755
uniprot id: F8E7D2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

717231:FLEXSI RS04545
gene id: 717231:FLEXSI_RS04545
uniprot id: F8E4Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

717231:FLEXSI RS01450
gene id: 717231:FLEXSI_RS01450
uniprot id: F8E860
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

717231:FLEXSI RS10505
gene id: 717231:FLEXSI_RS10505
uniprot id: F8E557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

717231:FLEXSI RS06640
gene id: 717231:FLEXSI_RS06640
uniprot id: F8E7H2
names: Similarity
messages: Belongs to the SfsA family.

717231:FLEXSI RS05590
gene id: 717231:FLEXSI_RS05590
uniprot id: F8E655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

717231:FLEXSI RS04410
gene id: 717231:FLEXSI_RS04410
uniprot id: F8E4W6
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09330
gene id: 717231:FLEXSI_RS09330
uniprot id: F8E3X4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

717231:FLEXSI RS11730
gene id: 717231:FLEXSI_RS11730
uniprot id: F8E6M5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS08530
gene id: 717231:FLEXSI_RS08530
uniprot id: F8E9J5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

717231:FLEXSI RS01875
gene id: 717231:FLEXSI_RS01875
uniprot id: F8E8M0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

717231:FLEXSI RS09195
gene id: 717231:FLEXSI_RS09195
uniprot id: F8E3U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

717231:FLEXSI RS07435
gene id: 717231:FLEXSI_RS07435
uniprot id: F8E8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS03955
gene id: 717231:FLEXSI_RS03955
uniprot id: F8E4H2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

717231:FLEXSI RS11915
gene id: 717231:FLEXSI_RS11915
uniprot id: F8E6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

717231:FLEXSI RS01245
gene id: 717231:FLEXSI_RS01245
uniprot id: F8E822
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

717231:FLEXSI RS04970
gene id: 717231:FLEXSI_RS04970
uniprot id: F8E5L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

717231:FLEXSI RS04800
gene id: 717231:FLEXSI_RS04800
uniprot id: F8E5B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

717231:FLEXSI RS08815
gene id: 717231:FLEXSI_RS08815
uniprot id: F8E9W6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

717231:FLEXSI RS10240
gene id: 717231:FLEXSI_RS10240
uniprot id: F8E507
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

717231:FLEXSI RS11335
gene id: 717231:FLEXSI_RS11335
uniprot id: F8E604
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

717231:FLEXSI RS08740
gene id: 717231:FLEXSI_RS08740
uniprot id: F8E9V3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

717231:FLEXSI RS09995
gene id: 717231:FLEXSI_RS09995
uniprot id: F8E4P1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

717231:FLEXSI RS06175
gene id: 717231:FLEXSI_RS06175
uniprot id: F8E710
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08265
gene id: 717231:FLEXSI_RS08265
uniprot id: F8E975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

717231:FLEXSI RS05645
gene id: 717231:FLEXSI_RS05645
uniprot id: F8E666
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

717231:FLEXSI RS07145
gene id: 717231:FLEXSI_RS07145
uniprot id: F8E7Y8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10370
gene id: 717231:FLEXSI_RS10370
uniprot id: F8E531
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

717231:FLEXSI RS10335
gene id: 717231:FLEXSI_RS10335
uniprot id: F8E526
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

717231:FLEXSI RS09120
gene id: 717231:FLEXSI_RS09120
uniprot id: F8E3T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS06020
gene id: 717231:FLEXSI_RS06020
uniprot id: F8E6K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

717231:FLEXSI RS09550
gene id: 717231:FLEXSI_RS09550
uniprot id: F8E488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

717231:FLEXSI RS01955
gene id: 717231:FLEXSI_RS01955
uniprot id: F8E8W2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

717231:FLEXSI RS10590
gene id: 717231:FLEXSI_RS10590
uniprot id: F8E5E6
names: Similarity
messages: Belongs to the peptidase S16 family.

717231:FLEXSI RS05125
gene id: 717231:FLEXSI_RS05125
uniprot id: F8E5P3
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS04540
gene id: 717231:FLEXSI_RS04540
uniprot id: F8E4Z2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

717231:FLEXSI RS00390
gene id: 717231:FLEXSI_RS00390
uniprot id: F8E6Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

717231:FLEXSI RS03635
gene id: 717231:FLEXSI_RS03635
uniprot id: F8E447
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

717231:FLEXSI RS05300
gene id: 717231:FLEXSI_RS05300
uniprot id: F8E5S4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

717231:FLEXSI RS00460
gene id: 717231:FLEXSI_RS00460
uniprot id: F8E773
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

717231:FLEXSI RS10455
gene id: 717231:FLEXSI_RS10455
uniprot id: F8E547
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06165
gene id: 717231:FLEXSI_RS06165
uniprot id: F8E708
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

717231:FLEXSI RS02400
gene id: 717231:FLEXSI_RS02400
uniprot id: F8E9B7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

717231:FLEXSI RS10720
gene id: 717231:FLEXSI_RS10720
uniprot id: F8E5G6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

717231:FLEXSI RS05725
gene id: 717231:FLEXSI_RS05725
uniprot id: F8E6F3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS03755
gene id: 717231:FLEXSI_RS03755
uniprot id: F8E468
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03915
gene id: 717231:FLEXSI_RS03915
uniprot id: F8E4G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS03030
gene id: 717231:FLEXSI_RS03030
uniprot id: F8E3L3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS01690
gene id: 717231:FLEXSI_RS01690
uniprot id: F8E8I4
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

717231:FLEXSI RS07875
gene id: 717231:FLEXSI_RS07875
uniprot id: F8E8S8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

717231:FLEXSI RS02760
gene id: 717231:FLEXSI_RS02760
uniprot id: F8E9Q1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

717231:FLEXSI RS04485
gene id: 717231:FLEXSI_RS04485
uniprot id: F8E4Y1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

717231:FLEXSI RS03170
gene id: 717231:FLEXSI_RS03170
uniprot id: F8E3N6
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

717231:FLEXSI RS06785
gene id: 717231:FLEXSI_RS06785
uniprot id: F8E7K2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

717231:FLEXSI RS03880
gene id: 717231:FLEXSI_RS03880
uniprot id: F8E4F7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

717231:FLEXSI RS05835
gene id: 717231:FLEXSI_RS05835
uniprot id: F8E6H3
names: Similarity
messages: Belongs to the archease family.

717231:FLEXSI RS03350
gene id: 717231:FLEXSI_RS03350
uniprot id: F8E3S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

717231:FLEXSI RS06345
gene id: 717231:FLEXSI_RS06345
uniprot id: F8E744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

717231:FLEXSI RS11305
gene id: 717231:FLEXSI_RS11305
uniprot id: F8E5Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

717231:FLEXSI RS04520
gene id: 717231:FLEXSI_RS04520
uniprot id: F8E4Y8
names: Similarity
messages: Belongs to the Fur family.

717231:FLEXSI RS08710
gene id: 717231:FLEXSI_RS08710
uniprot id: F8E9M9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

717231:FLEXSI RS12685
gene id: 717231:FLEXSI_RS12685
uniprot id: F8E791
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

717231:FLEXSI RS04435
gene id: 717231:FLEXSI_RS04435
uniprot id: F8E4X1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

717231:FLEXSI RS04075
gene id: 717231:FLEXSI_RS04075
uniprot id: F8E4J2
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS08375
gene id: 717231:FLEXSI_RS08375
uniprot id: F8E9G6
names: Similarity
messages: Belongs to the peptidase S1C family.

717231:FLEXSI RS05510
gene id: 717231:FLEXSI_RS05510
uniprot id: F8E641
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

717231:FLEXSI RS06800
gene id: 717231:FLEXSI_RS06800
uniprot id: F8E7K5
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

717231:FLEXSI RS02410
gene id: 717231:FLEXSI_RS02410
uniprot id: F8E9B9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

717231:FLEXSI RS04565
gene id: 717231:FLEXSI_RS04565
uniprot id: F8E4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

717231:FLEXSI RS02325
gene id: 717231:FLEXSI_RS02325
uniprot id: F8E9A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

717231:FLEXSI RS09940
gene id: 717231:FLEXSI_RS09940
uniprot id: F8E4N0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

717231:FLEXSI RS07055
gene id: 717231:FLEXSI_RS07055
uniprot id: F8E7X2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

717231:FLEXSI RS11485
gene id: 717231:FLEXSI_RS11485
uniprot id: F8E6A6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS11110
gene id: 717231:FLEXSI_RS11110
uniprot id: F8E5W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

717231:FLEXSI RS02380
gene id: 717231:FLEXSI_RS02380
uniprot id: F8E9B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

717231:FLEXSI RS09245
gene id: 717231:FLEXSI_RS09245
uniprot id: F8E3V7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

717231:FLEXSI RS02330
gene id: 717231:FLEXSI_RS02330
uniprot id: F8E9A3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

717231:FLEXSI RS02495
gene id: 717231:FLEXSI_RS02495
uniprot id: F8E9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

717231:FLEXSI RS09215
gene id: 717231:FLEXSI_RS09215
uniprot id: F8E3V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

717231:FLEXSI RS08595
gene id: 717231:FLEXSI_RS08595
uniprot id: F8E9K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

717231:FLEXSI RS08435
gene id: 717231:FLEXSI_RS08435
uniprot id: F8E9H6
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10730
gene id: 717231:FLEXSI_RS10730
uniprot id: F8E5G8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

717231:FLEXSI RS01360
gene id: 717231:FLEXSI_RS01360
uniprot id: F8E842
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS07940
gene id: 717231:FLEXSI_RS07940
uniprot id: F8E8U1
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

717231:FLEXSI RS11735
gene id: 717231:FLEXSI_RS11735
uniprot id: F8E6M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

717231:FLEXSI RS03930
gene id: 717231:FLEXSI_RS03930
uniprot id: F8E4G7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS11390
gene id: 717231:FLEXSI_RS11390
uniprot id: F8E690
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

717231:FLEXSI RS07935
gene id: 717231:FLEXSI_RS07935
uniprot id: F8E8U0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03135
gene id: 717231:FLEXSI_RS03135
uniprot id: F8E3M9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS07585
gene id: 717231:FLEXSI_RS07585
uniprot id: F8E8E6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

717231:FLEXSI RS09975
gene id: 717231:FLEXSI_RS09975
uniprot id: F8E4N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

717231:FLEXSI RS02450
gene id: 717231:FLEXSI_RS02450
uniprot id: F8E9C7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

717231:FLEXSI RS10380
gene id: 717231:FLEXSI_RS10380
uniprot id: F8E533
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

717231:FLEXSI RS10935
gene id: 717231:FLEXSI_RS10935
uniprot id: F8E5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

717231:FLEXSI RS10790
gene id: 717231:FLEXSI_RS10790
uniprot id: F8E5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

717231:FLEXSI RS08540
gene id: 717231:FLEXSI_RS08540
uniprot id: F8E9J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03095
gene id: 717231:FLEXSI_RS03095
uniprot id: F8E3M5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

717231:FLEXSI RS07365
gene id: 717231:FLEXSI_RS07365
uniprot id: F8E8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS02150
gene id: 717231:FLEXSI_RS02150
uniprot id: F8E902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS02190
gene id: 717231:FLEXSI_RS02190
uniprot id: F8E908
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

717231:FLEXSI RS02300
gene id: 717231:FLEXSI_RS02300
uniprot id: F8E997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

717231:FLEXSI RS07700
gene id: 717231:FLEXSI_RS07700
uniprot id: F8E8P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

717231:FLEXSI RS09320
gene id: 717231:FLEXSI_RS09320
uniprot id: F8E3X2
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS08600
gene id: 717231:FLEXSI_RS08600
uniprot id: F8E9K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

717231:FLEXSI RS08980
gene id: 717231:FLEXSI_RS08980
uniprot id: F8E9Z8
names: Similarity
messages: Belongs to the ParB family.

717231:FLEXSI RS04240
gene id: 717231:FLEXSI_RS04240
uniprot id: F8E4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

717231:FLEXSI RS00080
gene id: 717231:FLEXSI_RS00080
uniprot id: F8E6S8
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS02310
gene id: 717231:FLEXSI_RS02310
uniprot id: F8E999
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

717231:FLEXSI RS11330
gene id: 717231:FLEXSI_RS11330
uniprot id: F8E603
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

717231:FLEXSI RS06710
gene id: 717231:FLEXSI_RS06710
uniprot id: F8E7I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS07280
gene id: 717231:FLEXSI_RS07280
uniprot id: F8E886
names: Cofactor
messages: Binds 1 FAD per subunit.

717231:FLEXSI RS04725
gene id: 717231:FLEXSI_RS04725
uniprot id: F8E5A0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

717231:FLEXSI RS02520
gene id: 717231:FLEXSI_RS02520
uniprot id: F8E9E1
names: Similarity
messages: Belongs to the HypD family.

717231:FLEXSI RS10780
gene id: 717231:FLEXSI_RS10780
uniprot id: F8E5H8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS05195
gene id: 717231:FLEXSI_RS05195
uniprot id: F8E5Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

717231:FLEXSI RS07310
gene id: 717231:FLEXSI_RS07310
uniprot id: F8E892
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07275
gene id: 717231:FLEXSI_RS07275
uniprot id: F8E885
names: Similarity
messages: Belongs to the catalase family.

717231:FLEXSI RS09920
gene id: 717231:FLEXSI_RS09920
uniprot id: F8E4M6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

717231:FLEXSI RS04935
gene id: 717231:FLEXSI_RS04935
uniprot id: F8E5E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

717231:FLEXSI RS00675
gene id: 717231:FLEXSI_RS00675
uniprot id: F8E7B7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

717231:FLEXSI RS04325
gene id: 717231:FLEXSI_RS04325
uniprot id: F8E4V1
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

717231:FLEXSI RS07760
gene id: 717231:FLEXSI_RS07760
uniprot id: F8E8Q5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

717231:FLEXSI RS03280
gene id: 717231:FLEXSI_RS03280
uniprot id: F8E3Q7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

717231:FLEXSI RS07555
gene id: 717231:FLEXSI_RS07555
uniprot id: F8E8E0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS09890
gene id: 717231:FLEXSI_RS09890
uniprot id: F8E4M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

717231:FLEXSI RS09895
gene id: 717231:FLEXSI_RS09895
uniprot id: F8E4M1
names: Similarity
messages: Belongs to the Skp family.

717231:FLEXSI RS01125
gene id: 717231:FLEXSI_RS01125
uniprot id: F8E7S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS02420
gene id: 717231:FLEXSI_RS02420
uniprot id: F8E9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

717231:FLEXSI RS00465
gene id: 717231:FLEXSI_RS00465
uniprot id: F8E774
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

717231:FLEXSI RS00590
gene id: 717231:FLEXSI_RS00590
uniprot id: F8E7A0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

717231:FLEXSI RS03820
gene id: 717231:FLEXSI_RS03820
uniprot id: F8E4E8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

717231:FLEXSI RS06945
gene id: 717231:FLEXSI_RS06945
uniprot id: F8E7V1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

717231:FLEXSI RS08900
gene id: 717231:FLEXSI_RS08900
uniprot id: F8E9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

717231:FLEXSI RS00805
gene id: 717231:FLEXSI_RS00805
uniprot id: F8E7L3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

717231:FLEXSI RS09980
gene id: 717231:FLEXSI_RS09980
uniprot id: F8E4N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

717231:FLEXSI RS01010
gene id: 717231:FLEXSI_RS01010
uniprot id: F8E7Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

717231:FLEXSI RS09315
gene id: 717231:FLEXSI_RS09315
uniprot id: F8E3X1
names: Similarity
messages: Belongs to the peptidase S49 family.

717231:FLEXSI RS02935
gene id: 717231:FLEXSI_RS02935
uniprot id: F8E9T4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03945
gene id: 717231:FLEXSI_RS03945
uniprot id: F8E4H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

717231:FLEXSI RS01635
gene id: 717231:FLEXSI_RS01635
uniprot id: F8E8H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07465
gene id: 717231:FLEXSI_RS07465
uniprot id: F8E8C3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS05070
gene id: 717231:FLEXSI_RS05070
uniprot id: F8E5N2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

717231:FLEXSI RS01980
gene id: 717231:FLEXSI_RS01980
uniprot id: F8E8W8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

717231:FLEXSI RS02285
gene id: 717231:FLEXSI_RS02285
uniprot id: F8E994
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

717231:FLEXSI RS06170
gene id: 717231:FLEXSI_RS06170
uniprot id: F8E709
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

717231:FLEXSI RS07265
gene id: 717231:FLEXSI_RS07265
uniprot id: F8E883
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

717231:FLEXSI RS01175
gene id: 717231:FLEXSI_RS01175
uniprot id: F8E808
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

717231:FLEXSI RS01600
gene id: 717231:FLEXSI_RS01600
uniprot id: F8E8G6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

717231:FLEXSI RS08880
gene id: 717231:FLEXSI_RS08880
uniprot id: F8E4C4
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

717231:FLEXSI RS03100
gene id: 717231:FLEXSI_RS03100
uniprot id: F8E3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

717231:FLEXSI RS05020
gene id: 717231:FLEXSI_RS05020
uniprot id: F8E5M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS05315
gene id: 717231:FLEXSI_RS05315
uniprot id: F8E5S7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

717231:FLEXSI RS02765
gene id: 717231:FLEXSI_RS02765
uniprot id: F8E9Q2
names: Similarity
messages: Belongs to the universal stress protein A family.

717231:FLEXSI RS00640
gene id: 717231:FLEXSI_RS00640
uniprot id: F8E7B0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS02275
gene id: 717231:FLEXSI_RS02275
uniprot id: F8E992
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

717231:FLEXSI RS04045
gene id: 717231:FLEXSI_RS04045
uniprot id: F8E4I9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

717231:FLEXSI RS00960
gene id: 717231:FLEXSI_RS00960
uniprot id: F8E7P3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS09225
gene id: 717231:FLEXSI_RS09225
uniprot id: F8E3V3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

717231:FLEXSI RS10000
gene id: 717231:FLEXSI_RS10000
uniprot id: F8E4P2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

717231:FLEXSI RS00980
gene id: 717231:FLEXSI_RS00980
uniprot id: F8E7P7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS06015
gene id: 717231:FLEXSI_RS06015
uniprot id: F8E6K4
names: Similarity
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.

717231:FLEXSI RS04355
gene id: 717231:FLEXSI_RS04355
uniprot id: F8E4V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

717231:FLEXSI RS01205
gene id: 717231:FLEXSI_RS01205
uniprot id: F8E814
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

717231:FLEXSI RS02955
gene id: 717231:FLEXSI_RS02955
uniprot id: F8E9T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS03975
gene id: 717231:FLEXSI_RS03975
uniprot id: F8E4H6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

717231:FLEXSI RS00985
gene id: 717231:FLEXSI_RS00985
uniprot id: F8E7P8
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

717231:FLEXSI RS03815
gene id: 717231:FLEXSI_RS03815
uniprot id: F8E4E7
names: Similarity
messages: Belongs to the P(II) protein family.

717231:FLEXSI RS00095
gene id: 717231:FLEXSI_RS00095
uniprot id: F8E6T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

717231:FLEXSI RS07985
gene id: 717231:FLEXSI_RS07985
uniprot id: F8E921
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

717231:FLEXSI RS03750
gene id: 717231:FLEXSI_RS03750
uniprot id: F8E467
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11415
gene id: 717231:FLEXSI_RS11415
uniprot id: F8E694
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

717231:FLEXSI RS04245
gene id: 717231:FLEXSI_RS04245
uniprot id: F8E4T5
names: Similarity
messages: Belongs to the GSP E family.

717231:FLEXSI RS10365
gene id: 717231:FLEXSI_RS10365
uniprot id: F8E530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

717231:FLEXSI RS02985
gene id: 717231:FLEXSI_RS02985
uniprot id: F8E9U4
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10360
gene id: 717231:FLEXSI_RS10360
uniprot id: F8E529
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

717231:FLEXSI RS00990
gene id: 717231:FLEXSI_RS00990
uniprot id: F8E7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS07965
gene id: 717231:FLEXSI_RS07965
uniprot id: F8E917
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS04945
gene id: 717231:FLEXSI_RS04945
uniprot id: F8E5E3
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

717231:FLEXSI RS09000
gene id: 717231:FLEXSI_RS09000
uniprot id: F8EA02
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

717231:FLEXSI RS07530
gene id: 717231:FLEXSI_RS07530
uniprot id: F8E8D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

717231:FLEXSI RS03585
gene id: 717231:FLEXSI_RS03585
uniprot id: F8E439
names: Similarity
messages: Belongs to the glutamate synthase family.

717231:FLEXSI RS07835
gene id: 717231:FLEXSI_RS07835
uniprot id: F8E8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

717231:FLEXSI RS05660
gene id: 717231:FLEXSI_RS05660
uniprot id: F8E669
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

717231:FLEXSI RS04885
gene id: 717231:FLEXSI_RS04885
uniprot id: F8E5D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

717231:FLEXSI RS11230
gene id: 717231:FLEXSI_RS11230
uniprot id: F8E5Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

717231:FLEXSI RS10905
gene id: 717231:FLEXSI_RS10905
uniprot id: F8E5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

717231:FLEXSI RS04125
gene id: 717231:FLEXSI_RS04125
uniprot id: F8E4K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

717231:FLEXSI RS02305
gene id: 717231:FLEXSI_RS02305
uniprot id: F8E998
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

717231:FLEXSI RS05555
gene id: 717231:FLEXSI_RS05555
uniprot id: F8E648
names: Similarity
messages: Belongs to the ABC transporter superfamily.

717231:FLEXSI RS03965
gene id: 717231:FLEXSI_RS03965
uniprot id: F8E4H4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

717231:FLEXSI RS09910
gene id: 717231:FLEXSI_RS09910
uniprot id: F8E4M4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS04670
gene id: 717231:FLEXSI_RS04670
uniprot id: F8E591
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

717231:FLEXSI RS03155
gene id: 717231:FLEXSI_RS03155
uniprot id: F8E3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

717231:FLEXSI RS11225
gene id: 717231:FLEXSI_RS11225
uniprot id: F8E5Y3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS09100
gene id: 717231:FLEXSI_RS09100
uniprot id: F8EA19
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS00885
gene id: 717231:FLEXSI_RS00885
uniprot id: F8E7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

717231:FLEXSI RS10595
gene id: 717231:FLEXSI_RS10595
uniprot id: F8E5E7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

717231:FLEXSI RS07350
gene id: 717231:FLEXSI_RS07350
uniprot id: F8E8A0
names: Similarity
messages: Belongs to the histone deacetylase family.

717231:FLEXSI RS02290
gene id: 717231:FLEXSI_RS02290
uniprot id: F8E995
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

717231:FLEXSI RS05430
gene id: 717231:FLEXSI_RS05430
uniprot id: F8E625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

717231:FLEXSI RS09310
gene id: 717231:FLEXSI_RS09310
uniprot id: F8E3X0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

717231:FLEXSI RS10080
gene id: 717231:FLEXSI_RS10080
uniprot id: F8E4Q3
names: Similarity
messages: Belongs to the UPF0166 family.

717231:FLEXSI RS00785
gene id: 717231:FLEXSI_RS00785
uniprot id: F8E7D9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

717231:FLEXSI RS00025
gene id: 717231:FLEXSI_RS00025
uniprot id: F8E6E7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

717231:FLEXSI RS00615
gene id: 717231:FLEXSI_RS00615
uniprot id: F8E7A5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

717231:FLEXSI RS03920
gene id: 717231:FLEXSI_RS03920
uniprot id: F8E4G5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS04915
gene id: 717231:FLEXSI_RS04915
uniprot id: F8E5D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

717231:FLEXSI RS02715
gene id: 717231:FLEXSI_RS02715
uniprot id: F8E9P5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS05930
gene id: 717231:FLEXSI_RS05930
uniprot id: F8E6J1
names: Similarity
messages: Belongs to the peptidase M29 family.

717231:FLEXSI RS05350
gene id: 717231:FLEXSI_RS05350
uniprot id: F8E607
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09240
gene id: 717231:FLEXSI_RS09240
uniprot id: F8E3V6
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

717231:FLEXSI RS07515
gene id: 717231:FLEXSI_RS07515
uniprot id: F8E8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

717231:FLEXSI RS01660
gene id: 717231:FLEXSI_RS01660
uniprot id: F8E8H8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

717231:FLEXSI RS06735
gene id: 717231:FLEXSI_RS06735
uniprot id: F8E7J1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

717231:FLEXSI RS00090
gene id: 717231:FLEXSI_RS00090
uniprot id: F8E6T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

717231:FLEXSI RS07710
gene id: 717231:FLEXSI_RS07710
uniprot id: F8E8P5
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

717231:FLEXSI RS02775
gene id: 717231:FLEXSI_RS02775
uniprot id: F8E9Q4
names: Similarity
messages: Belongs to the hemerythrin family.

717231:FLEXSI RS00120
gene id: 717231:FLEXSI_RS00120
uniprot id: F8E6T6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

717231:FLEXSI RS04875
gene id: 717231:FLEXSI_RS04875
uniprot id: F8E5C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

717231:FLEXSI RS03255
gene id: 717231:FLEXSI_RS03255
uniprot id: F8E3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS10955
gene id: 717231:FLEXSI_RS10955
uniprot id: F8E5K6
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

717231:FLEXSI RS01040
gene id: 717231:FLEXSI_RS01040
uniprot id: F8E7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS08535
gene id: 717231:FLEXSI_RS08535
uniprot id: F8E9J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

717231:FLEXSI RS00385
gene id: 717231:FLEXSI_RS00385
uniprot id: F8E6Y7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

717231:FLEXSI RS05225
gene id: 717231:FLEXSI_RS05225
uniprot id: F8E5R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

717231:FLEXSI RS05595
gene id: 717231:FLEXSI_RS05595
uniprot id: F8E656
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08945
gene id: 717231:FLEXSI_RS08945
uniprot id: F8E9Z1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00920
gene id: 717231:FLEXSI_RS00920
uniprot id: F8E7N5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

717231:FLEXSI RS00100
gene id: 717231:FLEXSI_RS00100
uniprot id: F8E6T2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00650
gene id: 717231:FLEXSI_RS00650
uniprot id: F8E7B2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

717231:FLEXSI RS08490
gene id: 717231:FLEXSI_RS08490
uniprot id: F8E9I7
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

717231:FLEXSI RS01665
gene id: 717231:FLEXSI_RS01665
uniprot id: F8E8H9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

717231:FLEXSI RS01115
gene id: 717231:FLEXSI_RS01115
uniprot id: F8E7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

717231:FLEXSI RS10830
gene id: 717231:FLEXSI_RS10830
uniprot id: F8E5I8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

717231:FLEXSI RS01575
gene id: 717231:FLEXSI_RS01575
uniprot id: F8E8G1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00605
gene id: 717231:FLEXSI_RS00605
uniprot id: F8E7A3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

717231:FLEXSI RS00580
gene id: 717231:FLEXSI_RS00580
uniprot id: F8E798
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

717231:FLEXSI RS00075
gene id: 717231:FLEXSI_RS00075
uniprot id: F8E6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

717231:FLEXSI RS11470
gene id: 717231:FLEXSI_RS11470
uniprot id: F8E6A3
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

717231:FLEXSI RS10740
gene id: 717231:FLEXSI_RS10740
uniprot id: F8E5H0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

717231:FLEXSI RS07740
gene id: 717231:FLEXSI_RS07740
uniprot id: F8E8Q1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS05880
gene id: 717231:FLEXSI_RS05880
uniprot id: F8E6I1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS01000
gene id: 717231:FLEXSI_RS01000
uniprot id: F8E7Q1
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

717231:FLEXSI RS09655
gene id: 717231:FLEXSI_RS09655
uniprot id: F8E4A7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

717231:FLEXSI RS11360
gene id: 717231:FLEXSI_RS11360
uniprot id: F8E684
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00475
gene id: 717231:FLEXSI_RS00475
uniprot id: F8E777
names: Similarity
messages: Belongs to the universal stress protein A family.

717231:FLEXSI RS00995
gene id: 717231:FLEXSI_RS00995
uniprot id: F8E7Q0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

717231:FLEXSI RS05120
gene id: 717231:FLEXSI_RS05120
uniprot id: F8E5P2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS11340
gene id: 717231:FLEXSI_RS11340
uniprot id: F8E679
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11845
gene id: 717231:FLEXSI_RS11845
uniprot id: F8E6P5
names: Similarity
messages: Belongs to the UbiD family.

717231:FLEXSI RS08290
gene id: 717231:FLEXSI_RS08290
uniprot id: F8E980
names: Similarity
messages: Belongs to the LOG family.

717231:FLEXSI RS04980
gene id: 717231:FLEXSI_RS04980
uniprot id: F8E5L5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

717231:FLEXSI RS07750
gene id: 717231:FLEXSI_RS07750
uniprot id: F8E8Q3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

717231:FLEXSI RS04550
gene id: 717231:FLEXSI_RS04550
uniprot id: F8E4Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS07255
gene id: 717231:FLEXSI_RS07255
uniprot id: F8E881
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

717231:FLEXSI RS03630
gene id: 717231:FLEXSI_RS03630
uniprot id: F8E446
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS11875
gene id: 717231:FLEXSI_RS11875
uniprot id: F8E6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

717231:FLEXSI RS11785
gene id: 717231:FLEXSI_RS11785
uniprot id: F8E6N6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

717231:FLEXSI RS11310
gene id: 717231:FLEXSI_RS11310
uniprot id: F8E5Z9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10895
gene id: 717231:FLEXSI_RS10895
uniprot id: F8E5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

717231:FLEXSI RS12285
gene id: 717231:FLEXSI_RS12285
uniprot id: F8E509
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS11770
gene id: 717231:FLEXSI_RS11770
uniprot id: F8E6N3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

717231:FLEXSI RS04480
gene id: 717231:FLEXSI_RS04480
uniprot id: F8E4Y0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS04805
gene id: 717231:FLEXSI_RS04805
uniprot id: F8E5B5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

717231:FLEXSI RS03025
gene id: 717231:FLEXSI_RS03025
uniprot id: F8E3L2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03990
gene id: 717231:FLEXSI_RS03990
uniprot id: F8E4H9
names: Similarity
messages: Belongs to the GARS family.

717231:FLEXSI RS08475
gene id: 717231:FLEXSI_RS08475
uniprot id: F8E9I4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS01420
gene id: 717231:FLEXSI_RS01420
uniprot id: F8E854
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

717231:FLEXSI RS11985
gene id: 717231:FLEXSI_RS11985
uniprot id: F8E7P4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

717231:FLEXSI RS03790
gene id: 717231:FLEXSI_RS03790
uniprot id: F8E4E2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

717231:FLEXSI RS07050
gene id: 717231:FLEXSI_RS07050
uniprot id: F8E7X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

717231:FLEXSI RS05310
gene id: 717231:FLEXSI_RS05310
uniprot id: F8E5S6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07720
gene id: 717231:FLEXSI_RS07720
uniprot id: F8E8P7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

717231:FLEXSI RS06660
gene id: 717231:FLEXSI_RS06660
uniprot id: F8E7H6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

717231:FLEXSI RS05490
gene id: 717231:FLEXSI_RS05490
uniprot id: F8E637
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS05400
gene id: 717231:FLEXSI_RS05400
uniprot id: F8E618
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

717231:FLEXSI RS06880
gene id: 717231:FLEXSI_RS06880
uniprot id: F8E7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

717231:FLEXSI RS06750
gene id: 717231:FLEXSI_RS06750
uniprot id: F8E7J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

717231:FLEXSI RS07615
gene id: 717231:FLEXSI_RS07615
uniprot id: F8E8M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

717231:FLEXSI RS02525
gene id: 717231:FLEXSI_RS02525
uniprot id: F8E9E2
names: Similarity
messages: Belongs to the HypE family.

717231:FLEXSI RS10685
gene id: 717231:FLEXSI_RS10685
uniprot id: F8E5F9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

717231:FLEXSI RS11425
gene id: 717231:FLEXSI_RS11425
uniprot id: F8E696
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

717231:FLEXSI RS07635
gene id: 717231:FLEXSI_RS07635
uniprot id: F8E8N0
names: Similarity
messages: Belongs to the UPF0251 family.

717231:FLEXSI RS02385
gene id: 717231:FLEXSI_RS02385
uniprot id: F8E9B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

717231:FLEXSI RS08750
gene id: 717231:FLEXSI_RS08750
uniprot id: F8E9V5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

717231:FLEXSI RS01035
gene id: 717231:FLEXSI_RS01035
uniprot id: F8E7Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

717231:FLEXSI RS09220
gene id: 717231:FLEXSI_RS09220
uniprot id: F8E3V2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

717231:FLEXSI RS10265
gene id: 717231:FLEXSI_RS10265
uniprot id: F8E512
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS04845
gene id: 717231:FLEXSI_RS04845
uniprot id: F8E5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

717231:FLEXSI RS07990
gene id: 717231:FLEXSI_RS07990
uniprot id: F8E922
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

717231:FLEXSI RS10470
gene id: 717231:FLEXSI_RS10470
uniprot id: F8E550
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

717231:FLEXSI RS07625
gene id: 717231:FLEXSI_RS07625
uniprot id: F8E8M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

717231:FLEXSI RS04820
gene id: 717231:FLEXSI_RS04820
uniprot id: F8E5B8
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

717231:FLEXSI RS05235
gene id: 717231:FLEXSI_RS05235
uniprot id: F8E5R3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

717231:FLEXSI RS04910
gene id: 717231:FLEXSI_RS04910
uniprot id: F8E5D6
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

717231:FLEXSI RS01170
gene id: 717231:FLEXSI_RS01170
uniprot id: F8E807
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

717231:FLEXSI RS11885
gene id: 717231:FLEXSI_RS11885
uniprot id: F8E6Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

717231:FLEXSI RS07500
gene id: 717231:FLEXSI_RS07500
uniprot id: F8E8D0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

717231:FLEXSI RS02335
gene id: 717231:FLEXSI_RS02335
uniprot id: F8E9A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

717231:FLEXSI RS05475
gene id: 717231:FLEXSI_RS05475
uniprot id: F8E634
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07200
gene id: 717231:FLEXSI_RS07200
uniprot id: F8E7Z9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

717231:FLEXSI RS02580
gene id: 717231:FLEXSI_RS02580
uniprot id: F8E9F3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

717231:FLEXSI RS09170
gene id: 717231:FLEXSI_RS09170
uniprot id: F8E3U2
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11575
gene id: 717231:FLEXSI_RS11575
uniprot id: F8E6C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS06550
gene id: 717231:FLEXSI_RS06550
uniprot id: F8E7F6
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09845
gene id: 717231:FLEXSI_RS09845
uniprot id: F8E4L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS10305
gene id: 717231:FLEXSI_RS10305
uniprot id: F8E520
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

717231:FLEXSI RS00085
gene id: 717231:FLEXSI_RS00085
uniprot id: F8E6S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

717231:FLEXSI RS04250
gene id: 717231:FLEXSI_RS04250
uniprot id: F8E4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS10610
gene id: 717231:FLEXSI_RS10610
uniprot id: F8E5F0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS01650
gene id: 717231:FLEXSI_RS01650
uniprot id: F8E8H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

717231:FLEXSI RS11075
gene id: 717231:FLEXSI_RS11075
uniprot id: F8E5V3
names: Similarity
messages: Belongs to the RecJ family.

717231:FLEXSI RS03310
gene id: 717231:FLEXSI_RS03310
uniprot id: F8E3R3
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

717231:FLEXSI RS01685
gene id: 717231:FLEXSI_RS01685
uniprot id: F8E8I3
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

717231:FLEXSI RS11460
gene id: 717231:FLEXSI_RS11460
uniprot id: F8E6A1
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

717231:FLEXSI RS04030
gene id: 717231:FLEXSI_RS04030
uniprot id: F8E4I6
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

717231:FLEXSI RS01505
gene id: 717231:FLEXSI_RS01505
uniprot id: F8E8E7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

717231:FLEXSI RS05035
gene id: 717231:FLEXSI_RS05035
uniprot id: F8E5M5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

717231:FLEXSI RS10460
gene id: 717231:FLEXSI_RS10460
uniprot id: F8E548
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS11370
gene id: 717231:FLEXSI_RS11370
uniprot id: F8E686
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS10560
gene id: 717231:FLEXSI_RS10560
uniprot id: F8E567
names: Similarity
messages: Belongs to the peptidase C56 family.

717231:FLEXSI RS11290
gene id: 717231:FLEXSI_RS11290
uniprot id: F8E5Z5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

717231:FLEXSI RS02475
gene id: 717231:FLEXSI_RS02475
uniprot id: F8E9D2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS09010
gene id: 717231:FLEXSI_RS09010
uniprot id: F8EA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS04415
gene id: 717231:FLEXSI_RS04415
uniprot id: F8E4W7
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS10330
gene id: 717231:FLEXSI_RS10330
uniprot id: F8E525
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

717231:FLEXSI RS09205
gene id: 717231:FLEXSI_RS09205
uniprot id: F8E3U9
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

717231:FLEXSI RS00180
gene id: 717231:FLEXSI_RS00180
uniprot id: F8E6U8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

717231:FLEXSI RS04570
gene id: 717231:FLEXSI_RS04570
uniprot id: F8E572
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS07705
gene id: 717231:FLEXSI_RS07705
uniprot id: F8E8P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

717231:FLEXSI RS01015
gene id: 717231:FLEXSI_RS01015
uniprot id: F8E7Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS03715
gene id: 717231:FLEXSI_RS03715
uniprot id: F8E460
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06930
gene id: 717231:FLEXSI_RS06930
uniprot id: F8E7U8
names: Similarity
messages: Belongs to the peptidase S41A family.

717231:FLEXSI RS05630
gene id: 717231:FLEXSI_RS05630
uniprot id: F8E663
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

717231:FLEXSI RS02590
gene id: 717231:FLEXSI_RS02590
uniprot id: F8E9F5
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

717231:FLEXSI RS05495
gene id: 717231:FLEXSI_RS05495
uniprot id: F8E638
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

717231:FLEXSI RS02025
gene id: 717231:FLEXSI_RS02025
uniprot id: F8E8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

717231:FLEXSI RS04795
gene id: 717231:FLEXSI_RS04795
uniprot id: F8E5B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

717231:FLEXSI RS05260
gene id: 717231:FLEXSI_RS05260
uniprot id: F8E5R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

717231:FLEXSI RS00800
gene id: 717231:FLEXSI_RS00800
uniprot id: F8E7L2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

717231:FLEXSI RS07410
gene id: 717231:FLEXSI_RS07410
uniprot id: F8E8B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

717231:FLEXSI RS09560
gene id: 717231:FLEXSI_RS09560
uniprot id: F8E490
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03520
gene id: 717231:FLEXSI_RS03520
uniprot id: F8E425
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

717231:FLEXSI RS03995
gene id: 717231:FLEXSI_RS03995
uniprot id: F8E4I0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

717231:FLEXSI RS00940
gene id: 717231:FLEXSI_RS00940
uniprot id: F8E7N9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS04930
gene id: 717231:FLEXSI_RS04930
uniprot id: F8E5E0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS04900
gene id: 717231:FLEXSI_RS04900
uniprot id: F8E5D4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

717231:FLEXSI RS09335
gene id: 717231:FLEXSI_RS09335
uniprot id: F8E3X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

717231:FLEXSI RS00110
gene id: 717231:FLEXSI_RS00110
uniprot id: F8E6T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

717231:FLEXSI RS10775
gene id: 717231:FLEXSI_RS10775
uniprot id: F8E5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

717231:FLEXSI RS11235
gene id: 717231:FLEXSI_RS11235
uniprot id: F8E5Y5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

717231:FLEXSI RS00855
gene id: 717231:FLEXSI_RS00855
uniprot id: F8E7M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

717231:FLEXSI RS05980
gene id: 717231:FLEXSI_RS05980
uniprot id: F8E6K0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS06665
gene id: 717231:FLEXSI_RS06665
uniprot id: F8E7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS12155
gene id: 717231:FLEXSI_RS12155
uniprot id: F8E703
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00790
gene id: 717231:FLEXSI_RS00790
uniprot id: F8E7E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

717231:FLEXSI RS05780
gene id: 717231:FLEXSI_RS05780
uniprot id: F8E6G2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

717231:FLEXSI RS12290
gene id: 717231:FLEXSI_RS12290
uniprot id: F8E514
names: Similarity
messages: Belongs to the TrpF family.

717231:FLEXSI RS01055
gene id: 717231:FLEXSI_RS01055
uniprot id: F8E7R2
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

717231:FLEXSI RS07745
gene id: 717231:FLEXSI_RS07745
uniprot id: F8E8Q2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

717231:FLEXSI RS04420
gene id: 717231:FLEXSI_RS04420
uniprot id: F8E4W8
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

717231:FLEXSI RS04070
gene id: 717231:FLEXSI_RS04070
uniprot id: F8E4J1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03440
gene id: 717231:FLEXSI_RS03440
uniprot id: F8E409
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

717231:FLEXSI RS06000
gene id: 717231:FLEXSI_RS06000
uniprot id: F8E6K1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03645
gene id: 717231:FLEXSI_RS03645
uniprot id: F8E449
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS05620
gene id: 717231:FLEXSI_RS05620
uniprot id: F8E661
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

717231:FLEXSI RS05710
gene id: 717231:FLEXSI_RS05710
uniprot id: F8E6F0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

717231:FLEXSI RS08950
gene id: 717231:FLEXSI_RS08950
uniprot id: F8E9Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

717231:FLEXSI RS07610
gene id: 717231:FLEXSI_RS07610
uniprot id: F8E8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

717231:FLEXSI RS03800
gene id: 717231:FLEXSI_RS03800
uniprot id: F8E4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

717231:FLEXSI RS02600
gene id: 717231:FLEXSI_RS02600
uniprot id: F8E9F7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

717231:FLEXSI RS02260
gene id: 717231:FLEXSI_RS02260
uniprot id: F8E989
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

717231:FLEXSI RS05635
gene id: 717231:FLEXSI_RS05635
uniprot id: F8E664
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

717231:FLEXSI RS05345
gene id: 717231:FLEXSI_RS05345
uniprot id: F8E606
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

717231:FLEXSI RS02255
gene id: 717231:FLEXSI_RS02255
uniprot id: F8E916
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

717231:FLEXSI RS06475
gene id: 717231:FLEXSI_RS06475
uniprot id: F8E7E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

717231:FLEXSI RS08610
gene id: 717231:FLEXSI_RS08610
uniprot id: F8E9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

717231:FLEXSI RS05910
gene id: 717231:FLEXSI_RS05910
uniprot id: F8E6I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

717231:FLEXSI RS00975
gene id: 717231:FLEXSI_RS00975
uniprot id: F8E7P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS11080
gene id: 717231:FLEXSI_RS11080
uniprot id: F8E5V4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

717231:FLEXSI RS03500
gene id: 717231:FLEXSI_RS03500
uniprot id: F8E421
names: Cofactor
messages: The heme is bound between the two transmembrane subunits.

717231:FLEXSI RS02355
gene id: 717231:FLEXSI_RS02355
uniprot id: F8E9A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

717231:FLEXSI RS10975
gene id: 717231:FLEXSI_RS10975
uniprot id: F8E5T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS02230
gene id: 717231:FLEXSI_RS02230
uniprot id: F8E997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

717231:FLEXSI RS00830
gene id: 717231:FLEXSI_RS00830
uniprot id: F8E7L8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

717231:FLEXSI RS03580
gene id: 717231:FLEXSI_RS03580
uniprot id: F8E438
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

717231:FLEXSI RS03570
gene id: 717231:FLEXSI_RS03570
uniprot id: F8E436
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08565
gene id: 717231:FLEXSI_RS08565
uniprot id: F8E9K2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03455
gene id: 717231:FLEXSI_RS03455
uniprot id: F8E412
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

717231:FLEXSI RS00240
gene id: 717231:FLEXSI_RS00240
uniprot id: F8E6V9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11945
gene id: 717231:FLEXSI_RS11945
uniprot id: F8E6R5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

717231:FLEXSI RS03780
gene id: 717231:FLEXSI_RS03780
uniprot id: F8E473
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS05360
gene id: 717231:FLEXSI_RS05360
uniprot id: F8E610
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

717231:FLEXSI RS09260
gene id: 717231:FLEXSI_RS09260
uniprot id: F8E3W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

717231:FLEXSI RS10795
gene id: 717231:FLEXSI_RS10795
uniprot id: F8E5I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

717231:FLEXSI RS11055
gene id: 717231:FLEXSI_RS11055
uniprot id: F8E5U9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS02125
gene id: 717231:FLEXSI_RS02125
uniprot id: F8E8Z6
names: Similarity
messages: Belongs to the FPG family.

717231:FLEXSI RS11365
gene id: 717231:FLEXSI_RS11365
uniprot id: F8E685
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS01090
gene id: 717231:FLEXSI_RS01090
uniprot id: F8E7R9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

717231:FLEXSI RS00210
gene id: 717231:FLEXSI_RS00210
uniprot id: F8E6V5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

717231:FLEXSI RS12630
gene id: 717231:FLEXSI_RS12630
uniprot id: F8E7X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

717231:FLEXSI RS06485
gene id: 717231:FLEXSI_RS06485
uniprot id: F8E7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

717231:FLEXSI RS03175
gene id: 717231:FLEXSI_RS03175
uniprot id: F8E3N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

717231:FLEXSI RS01515
gene id: 717231:FLEXSI_RS01515
uniprot id: F8E8E9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00600
gene id: 717231:FLEXSI_RS00600
uniprot id: F8E7A2
names: Similarity
messages: Belongs to the fabD family.

717231:FLEXSI RS06030
gene id: 717231:FLEXSI_RS06030
uniprot id: F8E6K7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

717231:FLEXSI RS11810
gene id: 717231:FLEXSI_RS11810
uniprot id: F8E6P1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS08100
gene id: 717231:FLEXSI_RS08100
uniprot id: F8E945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

717231:FLEXSI RS00335
gene id: 717231:FLEXSI_RS00335
uniprot id: F8E6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

717231:FLEXSI RS09740
gene id: 717231:FLEXSI_RS09740
uniprot id: F8E4C4
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

717231:FLEXSI RS06040
gene id: 717231:FLEXSI_RS06040
uniprot id: F8E6K9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

717231:FLEXSI RS04920
gene id: 717231:FLEXSI_RS04920
uniprot id: F8E5D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

717231:FLEXSI RS00370
gene id: 717231:FLEXSI_RS00370
uniprot id: F8E6Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

717231:FLEXSI RS07650
gene id: 717231:FLEXSI_RS07650
uniprot id: F8E8N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

717231:FLEXSI RS06335
gene id: 717231:FLEXSI_RS06335
uniprot id: F8E742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

717231:FLEXSI RS08350
gene id: 717231:FLEXSI_RS08350
uniprot id: F8E9G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

717231:FLEXSI RS08970
gene id: 717231:FLEXSI_RS08970
uniprot id: F8E9Z6
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09935
gene id: 717231:FLEXSI_RS09935
uniprot id: F8E4M9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

717231:FLEXSI RS02390
gene id: 717231:FLEXSI_RS02390
uniprot id: F8E9B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

717231:FLEXSI RS08555
gene id: 717231:FLEXSI_RS08555
uniprot id: F8E9K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

717231:FLEXSI RS09125
gene id: 717231:FLEXSI_RS09125
uniprot id: F8E3T3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

717231:FLEXSI RS07030
gene id: 717231:FLEXSI_RS07030
uniprot id: F8E7W7
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS01440
gene id: 717231:FLEXSI_RS01440
uniprot id: F8E858
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

717231:FLEXSI RS04575
gene id: 717231:FLEXSI_RS04575
uniprot id: F8E573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

717231:FLEXSI RS02370
gene id: 717231:FLEXSI_RS02370
uniprot id: F8E9B1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

717231:FLEXSI RS05720
gene id: 717231:FLEXSI_RS05720
uniprot id: F8E6F2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

717231:FLEXSI RS10515
gene id: 717231:FLEXSI_RS10515
uniprot id: F8E559
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

717231:FLEXSI RS01050
gene id: 717231:FLEXSI_RS01050
uniprot id: F8E7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

717231:FLEXSI RS06095
gene id: 717231:FLEXSI_RS06095
uniprot id: F8E6Z4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS08715
gene id: 717231:FLEXSI_RS08715
uniprot id: F8E9N0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

717231:FLEXSI RS05825
gene id: 717231:FLEXSI_RS05825
uniprot id: F8E6H1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

717231:FLEXSI RS05230
gene id: 717231:FLEXSI_RS05230
uniprot id: F8E5R2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

717231:FLEXSI RS08520
gene id: 717231:FLEXSI_RS08520
uniprot id: F8E9J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

717231:FLEXSI RS09090
gene id: 717231:FLEXSI_RS09090
uniprot id: F8EA17
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

717231:FLEXSI RS00395
gene id: 717231:FLEXSI_RS00395
uniprot id: F8E6Y9
names: Similarity
messages: Belongs to the threonine synthase family.

717231:FLEXSI RS02365
gene id: 717231:FLEXSI_RS02365
uniprot id: F8E9B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

717231:FLEXSI RS05060
gene id: 717231:FLEXSI_RS05060
uniprot id: F8E5N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

717231:FLEXSI RS10105
gene id: 717231:FLEXSI_RS10105
uniprot id: F8E4Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

717231:FLEXSI RS05050
gene id: 717231:FLEXSI_RS05050
uniprot id: F8E5M8
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS02405
gene id: 717231:FLEXSI_RS02405
uniprot id: F8E9B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

717231:FLEXSI RS04510
gene id: 717231:FLEXSI_RS04510
uniprot id: F8E4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

717231:FLEXSI RS09965
gene id: 717231:FLEXSI_RS09965
uniprot id: F8E4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

717231:FLEXSI RS07415
gene id: 717231:FLEXSI_RS07415
uniprot id: F8E8B3
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

717231:FLEXSI RS02320
gene id: 717231:FLEXSI_RS02320
uniprot id: F8E9A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

717231:FLEXSI RS12235
gene id: 717231:FLEXSI_RS12235
uniprot id: F8E3Y9
names: Similarity
messages: Belongs to the ketopantoate reductase family.

717231:FLEXSI RS04040
gene id: 717231:FLEXSI_RS04040
uniprot id: F8E4I8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

717231:FLEXSI RS03015
gene id: 717231:FLEXSI_RS03015
uniprot id: F8E3L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

717231:FLEXSI RS00255
gene id: 717231:FLEXSI_RS00255
uniprot id: F8E6W2
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

717231:FLEXSI RS04345
gene id: 717231:FLEXSI_RS04345
uniprot id: F8E4V5
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

717231:FLEXSI RS11475
gene id: 717231:FLEXSI_RS11475
uniprot id: F8E6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS09370
gene id: 717231:FLEXSI_RS09370
uniprot id: F8E3Y2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS03985
gene id: 717231:FLEXSI_RS03985
uniprot id: F8E4H8
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

717231:FLEXSI RS06765
gene id: 717231:FLEXSI_RS06765
uniprot id: F8E7J7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS00165
gene id: 717231:FLEXSI_RS00165
uniprot id: F8E6U5
names: Similarity
messages: Belongs to the acylphosphatase family.

717231:FLEXSI RS11750
gene id: 717231:FLEXSI_RS11750
uniprot id: F8E6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

717231:FLEXSI RS00115
gene id: 717231:FLEXSI_RS00115
uniprot id: F8E6T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

717231:FLEXSI RS09905
gene id: 717231:FLEXSI_RS09905
uniprot id: F8E4M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

717231:FLEXSI RS07790
gene id: 717231:FLEXSI_RS07790
uniprot id: F8E8R1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06470
gene id: 717231:FLEXSI_RS06470
uniprot id: F8E7E2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

717231:FLEXSI RS00595
gene id: 717231:FLEXSI_RS00595
uniprot id: F8E7A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

717231:FLEXSI RS00260
gene id: 717231:FLEXSI_RS00260
uniprot id: F8E6W3
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

717231:FLEXSI RS03775
gene id: 717231:FLEXSI_RS03775
uniprot id: F8E472
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07970
gene id: 717231:FLEXSI_RS07970
uniprot id: F8E918
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03410
gene id: 717231:FLEXSI_RS03410
uniprot id: F8E403
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

717231:FLEXSI RS09680
gene id: 717231:FLEXSI_RS09680
uniprot id: F8E4B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

717231:FLEXSI RS03980
gene id: 717231:FLEXSI_RS03980
uniprot id: F8E4H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

717231:FLEXSI RS05365
gene id: 717231:FLEXSI_RS05365
uniprot id: F8E611
names: Similarity
messages: Belongs to the UPF0047 family.

717231:FLEXSI RS10245
gene id: 717231:FLEXSI_RS10245
uniprot id: F8E508
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

717231:FLEXSI RS10495
gene id: 717231:FLEXSI_RS10495
uniprot id: F8E555
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

717231:FLEXSI RS07325
gene id: 717231:FLEXSI_RS07325
uniprot id: F8E895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

717231:FLEXSI RS04360
gene id: 717231:FLEXSI_RS04360
uniprot id: F8E4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

717231:FLEXSI RS12310
gene id: 717231:FLEXSI_RS12310
uniprot id: F8E5K0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

717231:FLEXSI RS08515
gene id: 717231:FLEXSI_RS08515
uniprot id: F8E9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

717231:FLEXSI RS11325
gene id: 717231:FLEXSI_RS11325
uniprot id: F8E602
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

717231:FLEXSI RS04165
gene id: 717231:FLEXSI_RS04165
uniprot id: F8E4K6
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

717231:FLEXSI RS07785
gene id: 717231:FLEXSI_RS07785
uniprot id: F8E8R0
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00740
gene id: 717231:FLEXSI_RS00740
uniprot id: F8E7C9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

717231:FLEXSI RS02295
gene id: 717231:FLEXSI_RS02295
uniprot id: F8E996
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

717231:FLEXSI RS09155
gene id: 717231:FLEXSI_RS09155
uniprot id: F8E3T9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS01145
gene id: 717231:FLEXSI_RS01145
uniprot id: F8E801
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

717231:FLEXSI RS09620
gene id: 717231:FLEXSI_RS09620
uniprot id: F8E4A0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

717231:FLEXSI RS12915
gene id: 717231:FLEXSI_RS12915
uniprot id: F8E406
names: Similarity
messages: Belongs to the class-I fumarase family.

717231:FLEXSI RS06060
gene id: 717231:FLEXSI_RS06060
uniprot id: F8E6L3
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS06200
gene id: 717231:FLEXSI_RS06200
uniprot id: F8E715
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08335
gene id: 717231:FLEXSI_RS08335
uniprot id: F8E987
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

717231:FLEXSI RS10900
gene id: 717231:FLEXSI_RS10900
uniprot id: F8E5J6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

717231:FLEXSI RS06115
gene id: 717231:FLEXSI_RS06115
uniprot id: F8E6Z8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

717231:FLEXSI RS01030
gene id: 717231:FLEXSI_RS01030
uniprot id: F8E7Q7
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS08960
gene id: 717231:FLEXSI_RS08960
uniprot id: F8E9Z4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

717231:FLEXSI RS07290
gene id: 717231:FLEXSI_RS07290
uniprot id: F8E888
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS01325
gene id: 717231:FLEXSI_RS01325
uniprot id: F8E835
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09420
gene id: 717231:FLEXSI_RS09420
uniprot id: F8E3Z2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

717231:FLEXSI RS01995
gene id: 717231:FLEXSI_RS01995
uniprot id: F8E8X1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

717231:FLEXSI RS07955
gene id: 717231:FLEXSI_RS07955
uniprot id: F8E8U4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

717231:FLEXSI RS02845
gene id: 717231:FLEXSI_RS02845
uniprot id: F8E9R7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS09390
gene id: 717231:FLEXSI_RS09390
uniprot id: F8E3Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

717231:FLEXSI RS11350
gene id: 717231:FLEXSI_RS11350
uniprot id: F8E682
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11950
gene id: 717231:FLEXSI_RS11950
uniprot id: F8E6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

717231:FLEXSI RS00715
gene id: 717231:FLEXSI_RS00715
uniprot id: F8E7C4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

717231:FLEXSI RS06940
gene id: 717231:FLEXSI_RS06940
uniprot id: F8E7V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

717231:FLEXSI RS11800
gene id: 717231:FLEXSI_RS11800
uniprot id: F8E6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

717231:FLEXSI RS09020
gene id: 717231:FLEXSI_RS09020
uniprot id: F8EA06
names: Similarity
messages: Belongs to the UPF0758 family.

717231:FLEXSI RS06460
gene id: 717231:FLEXSI_RS06460
uniprot id: F8E764
names: Similarity
messages: Belongs to the TlyA family.

717231:FLEXSI RS06290
gene id: 717231:FLEXSI_RS06290
uniprot id: F8E733
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03605
gene id: 717231:FLEXSI_RS03605
uniprot id: F8E443
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00020
gene id: 717231:FLEXSI_RS00020
uniprot id: F8E6E6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

717231:FLEXSI RS07730
gene id: 717231:FLEXSI_RS07730
uniprot id: F8E8P9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07190
gene id: 717231:FLEXSI_RS07190
uniprot id: F8E7Z7
names: Similarity
messages: Belongs to the RutC family.

717231:FLEXSI RS02915
gene id: 717231:FLEXSI_RS02915
uniprot id: F8E9T0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

717231:FLEXSI RS00350
gene id: 717231:FLEXSI_RS00350
uniprot id: F8E6Y0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

717231:FLEXSI RS08700
gene id: 717231:FLEXSI_RS08700
uniprot id: F8E9M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

717231:FLEXSI RS06135
gene id: 717231:FLEXSI_RS06135
uniprot id: F8E702
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

717231:FLEXSI RS06155
gene id: 717231:FLEXSI_RS06155
uniprot id: F8E706
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS03485
gene id: 717231:FLEXSI_RS03485
uniprot id: F8E418
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

717231:FLEXSI RS10810
gene id: 717231:FLEXSI_RS10810
uniprot id: F8E5I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

717231:FLEXSI RS05830
gene id: 717231:FLEXSI_RS05830
uniprot id: F8E6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

717231:FLEXSI RS05500
gene id: 717231:FLEXSI_RS05500
uniprot id: F8E639
names: Similarity
messages: Belongs to the DtxR/MntR family.

717231:FLEXSI RS02265
gene id: 717231:FLEXSI_RS02265
uniprot id: F8E990
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

717231:FLEXSI RS11630
gene id: 717231:FLEXSI_RS11630
uniprot id: F8E6D0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

717231:FLEXSI RS10285
gene id: 717231:FLEXSI_RS10285
uniprot id: F8E516
names: Similarity
messages: Belongs to the TrpA family.

717231:FLEXSI RS11315
gene id: 717231:FLEXSI_RS11315
uniprot id: F8E600
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

717231:FLEXSI RS09720
gene id: 717231:FLEXSI_RS09720
uniprot id: F8E4C0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

717231:FLEXSI RS00660
gene id: 717231:FLEXSI_RS00660
uniprot id: F8E7B4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

717231:FLEXSI RS07225
gene id: 717231:FLEXSI_RS07225
uniprot id: F8E875
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

717231:FLEXSI RS08420
gene id: 717231:FLEXSI_RS08420
uniprot id: F8E9H3
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

717231:FLEXSI RS00045
gene id: 717231:FLEXSI_RS00045
uniprot id: F8E6S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

717231:FLEXSI RS06920
gene id: 717231:FLEXSI_RS06920
uniprot id: F8E7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

717231:FLEXSI RS04835
gene id: 717231:FLEXSI_RS04835
uniprot id: F8E5C1
names: Similarity
messages: Belongs to the peptidase A31 family.

717231:FLEXSI RS06955
gene id: 717231:FLEXSI_RS06955
uniprot id: F8E7V3
names: Similarity
messages: Belongs to the GSP E family.

717231:FLEXSI RS08560
gene id: 717231:FLEXSI_RS08560
uniprot id: F8E9K1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

717231:FLEXSI RS05650
gene id: 717231:FLEXSI_RS05650
uniprot id: F8E667
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

717231:FLEXSI RS00525
gene id: 717231:FLEXSI_RS00525
uniprot id: F8E787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

717231:FLEXSI RS02360
gene id: 717231:FLEXSI_RS02360
uniprot id: F8E9A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

717231:FLEXSI RS11380
gene id: 717231:FLEXSI_RS11380
uniprot id: F8E688
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS04840
gene id: 717231:FLEXSI_RS04840
uniprot id: F8E5C2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

717231:FLEXSI RS01570
gene id: 717231:FLEXSI_RS01570
uniprot id: F8E8G0
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00655
gene id: 717231:FLEXSI_RS00655
uniprot id: F8E7B3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

717231:FLEXSI RS06525
gene id: 717231:FLEXSI_RS06525
uniprot id: F8E7F1
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11185
gene id: 717231:FLEXSI_RS11185
uniprot id: F8E5X5
names: Similarity
messages: Belongs to the UPF0102 family.

717231:FLEXSI RS07150
gene id: 717231:FLEXSI_RS07150
uniprot id: F8E7Y9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS10760
gene id: 717231:FLEXSI_RS10760
uniprot id: F8E5H4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

717231:FLEXSI RS06185
gene id: 717231:FLEXSI_RS06185
uniprot id: F8E712
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS08915
gene id: 717231:FLEXSI_RS08915
uniprot id: F8E9Y4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00825
gene id: 717231:FLEXSI_RS00825
uniprot id: F8E7L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

717231:FLEXSI RS05870
gene id: 717231:FLEXSI_RS05870
uniprot id: F8E6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

717231:FLEXSI RS05085
gene id: 717231:FLEXSI_RS05085
uniprot id: F8E5N5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

717231:FLEXSI RS02440
gene id: 717231:FLEXSI_RS02440
uniprot id: F8E9C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

717231:FLEXSI RS06840
gene id: 717231:FLEXSI_RS06840
uniprot id: F8E7T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

717231:FLEXSI RS07490
gene id: 717231:FLEXSI_RS07490
uniprot id: F8E8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

717231:FLEXSI RS01025
gene id: 717231:FLEXSI_RS01025
uniprot id: F8E7Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

717231:FLEXSI RS03305
gene id: 717231:FLEXSI_RS03305
uniprot id: F8E3R2
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

717231:FLEXSI RS01780
gene id: 717231:FLEXSI_RS01780
uniprot id: F8E8K1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

717231:FLEXSI RS11045
gene id: 717231:FLEXSI_RS11045
uniprot id: F8E5U7
names: Subcellular Location Annotation
messages: Cytoplasm

717231:FLEXSI RS09535
gene id: 717231:FLEXSI_RS09535
uniprot id: F8E485
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS00375
gene id: 717231:FLEXSI_RS00375
uniprot id: F8E6Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

717231:FLEXSI RS04495
gene id: 717231:FLEXSI_RS04495
uniprot id: F8E4Y3
names: Similarity
messages: Belongs to the MreC family.

717231:FLEXSI RS12225
gene id: 717231:FLEXSI_RS12225
uniprot id: F8E9Y3
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS04155
gene id: 717231:FLEXSI_RS04155
uniprot id: F8E4K4
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

717231:FLEXSI RS02315
gene id: 717231:FLEXSI_RS02315
uniprot id: F8E9A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

717231:FLEXSI RS11355
gene id: 717231:FLEXSI_RS11355
uniprot id: F8E683
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09970
gene id: 717231:FLEXSI_RS09970
uniprot id: F8E4N6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

717231:FLEXSI RS05015
gene id: 717231:FLEXSI_RS05015
uniprot id: F8E5M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

717231:FLEXSI RS05480
gene id: 717231:FLEXSI_RS05480
uniprot id: F8E635
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

717231:FLEXSI RS11925
gene id: 717231:FLEXSI_RS11925
uniprot id: F8E6R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

717231:FLEXSI RS08995
gene id: 717231:FLEXSI_RS08995
uniprot id: F8EA01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

717231:FLEXSI RS07820
gene id: 717231:FLEXSI_RS07820
uniprot id: F8E8R7
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

717231:FLEXSI RS10600
gene id: 717231:FLEXSI_RS10600
uniprot id: F8E5E8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS08390
gene id: 717231:FLEXSI_RS08390
uniprot id: F8E9G9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

717231:FLEXSI RS00265
gene id: 717231:FLEXSI_RS00265
uniprot id: F8E6W4
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

717231:FLEXSI RS03130
gene id: 717231:FLEXSI_RS03130
uniprot id: F8E3M8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

717231:FLEXSI RS08145
gene id: 717231:FLEXSI_RS08145
uniprot id: F8E954
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

717231:FLEXSI RS04985
gene id: 717231:FLEXSI_RS04985
uniprot id: F8E5L6
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

717231:FLEXSI RS10085
gene id: 717231:FLEXSI_RS10085
uniprot id: F8E4Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

717231:FLEXSI RS10415
gene id: 717231:FLEXSI_RS10415
uniprot id: F8E540
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

717231:FLEXSI RS09305
gene id: 717231:FLEXSI_RS09305
uniprot id: F8E3W9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

717231:FLEXSI RS00175
gene id: 717231:FLEXSI_RS00175
uniprot id: F8E6U7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

717231:FLEXSI RS09830
gene id: 717231:FLEXSI_RS09830
uniprot id: F8E4D9
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

717231:FLEXSI RS02675
gene id: 717231:FLEXSI_RS02675
uniprot id: F8E9N7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

717231:FLEXSI RS07800
gene id: 717231:FLEXSI_RS07800
uniprot id: F8E8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

717231:FLEXSI RS05860
gene id: 717231:FLEXSI_RS05860
uniprot id: F8E6H7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS02200
gene id: 717231:FLEXSI_RS02200
uniprot id: F8E910
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

717231:FLEXSI RS07665
gene id: 717231:FLEXSI_RS07665
uniprot id: F8E8N6
names: Similarity
messages: Belongs to the UPF0251 family.

717231:FLEXSI RS10990
gene id: 717231:FLEXSI_RS10990
uniprot id: F8E5T5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

717231:FLEXSI RS09095
gene id: 717231:FLEXSI_RS09095
uniprot id: F8EA18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

717231:FLEXSI RS08505
gene id: 717231:FLEXSI_RS08505
uniprot id: F8E9J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

717231:FLEXSI RS05790
gene id: 717231:FLEXSI_RS05790
uniprot id: F8E6G4
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

717231:FLEXSI RS04680
gene id: 717231:FLEXSI_RS04680
uniprot id: F8E593
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS01960
gene id: 717231:FLEXSI_RS01960
uniprot id: F8E8W3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

717231:FLEXSI RS08620
gene id: 717231:FLEXSI_RS08620
uniprot id: F8E9L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

717231:FLEXSI RS01355
gene id: 717231:FLEXSI_RS01355
uniprot id: F8E841
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS11010
gene id: 717231:FLEXSI_RS11010
uniprot id: F8E5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

717231:FLEXSI RS01965
gene id: 717231:FLEXSI_RS01965
uniprot id: F8E8W4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

717231:FLEXSI RS08615
gene id: 717231:FLEXSI_RS08615
uniprot id: F8E9L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

717231:FLEXSI RS11835
gene id: 717231:FLEXSI_RS11835
uniprot id: F8E6P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

717231:FLEXSI RS03330
gene id: 717231:FLEXSI_RS03330
uniprot id: F8E3R7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

717231:FLEXSI RS09545
gene id: 717231:FLEXSI_RS09545
uniprot id: F8E487
names: Similarity
messages: Belongs to the UPF0423 family.

717231:FLEXSI RS09295
gene id: 717231:FLEXSI_RS09295
uniprot id: F8E3W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

717231:FLEXSI RS01655
gene id: 717231:FLEXSI_RS01655
uniprot id: F8E8H7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

717231:FLEXSI RS11790
gene id: 717231:FLEXSI_RS11790
uniprot id: F8E6N7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

717231:FLEXSI RS05580
gene id: 717231:FLEXSI_RS05580
uniprot id: F8E653
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

717231:FLEXSI RS06065
gene id: 717231:FLEXSI_RS06065
uniprot id: F8E6L4
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS07160
gene id: 717231:FLEXSI_RS07160
uniprot id: F8E7Z1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

717231:FLEXSI RS05520
gene id: 717231:FLEXSI_RS05520
uniprot id: F8E643
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

717231:FLEXSI RS10075
gene id: 717231:FLEXSI_RS10075
uniprot id: F8E4Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

717231:FLEXSI RS07845
gene id: 717231:FLEXSI_RS07845
uniprot id: F8E8S2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

717231:FLEXSI RS02660
gene id: 717231:FLEXSI_RS02660
uniprot id: F8E9N4
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

717231:FLEXSI RS00190
gene id: 717231:FLEXSI_RS00190
uniprot id: F8E6V1
names: Similarity
messages: Belongs to the IMPACT family.

717231:FLEXSI RS04365
gene id: 717231:FLEXSI_RS04365
uniprot id: F8E4V9
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS03970
gene id: 717231:FLEXSI_RS03970
uniprot id: F8E4H5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS09885
gene id: 717231:FLEXSI_RS09885
uniprot id: F8E4L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

717231:FLEXSI RS03450
gene id: 717231:FLEXSI_RS03450
uniprot id: F8E411
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

717231:FLEXSI RS06050
gene id: 717231:FLEXSI_RS06050
uniprot id: F8E6L1
names: Similarity
messages: Belongs to the leucine-binding protein family.

717231:FLEXSI RS01100
gene id: 717231:FLEXSI_RS01100
uniprot id: F8E7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

717231:FLEXSI RS03480
gene id: 717231:FLEXSI_RS03480
uniprot id: F8E417
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

717231:FLEXSI RS11125
gene id: 717231:FLEXSI_RS11125
uniprot id: F8E5W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

717231:FLEXSI RS05080
gene id: 717231:FLEXSI_RS05080
uniprot id: F8E5N4
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

717231:FLEXSI RS12105
gene id: 717231:FLEXSI_RS12105
uniprot id: F8E578
names: Similarity
messages: Belongs to the YggT family.

717231:FLEXSI RS11320
gene id: 717231:FLEXSI_RS11320
uniprot id: F8E601
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

717231:FLEXSI RS11640
gene id: 717231:FLEXSI_RS11640
uniprot id: F8E6D2
names: Similarity
messages: Belongs to the DinB family.

717231:FLEXSI RS01140
gene id: 717231:FLEXSI_RS01140
uniprot id: F8E7S9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

717231:FLEXSI RS02415
gene id: 717231:FLEXSI_RS02415
uniprot id: F8E9C0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

717231:FLEXSI RS02350
gene id: 717231:FLEXSI_RS02350
uniprot id: F8E9A7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

717231:FLEXSI RS07315
gene id: 717231:FLEXSI_RS07315
uniprot id: F8E893
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

717231:FLEXSI RS06625
gene id: 717231:FLEXSI_RS06625
uniprot id: F8E7G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

717231:FLEXSI RS01220
gene id: 717231:FLEXSI_RS01220
uniprot id: F8E817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

717231:FLEXSI RS02770
gene id: 717231:FLEXSI_RS02770
uniprot id: F8E9Q3
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS05810
gene id: 717231:FLEXSI_RS05810
uniprot id: F8E6G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

717231:FLEXSI RS01915
gene id: 717231:FLEXSI_RS01915
uniprot id: F8E8V4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

717231:FLEXSI RS00610
gene id: 717231:FLEXSI_RS00610
uniprot id: F8E7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

717231:FLEXSI RS08990
gene id: 717231:FLEXSI_RS08990
uniprot id: F8EA00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

717231:FLEXSI RS04310
gene id: 717231:FLEXSI_RS04310
uniprot id: F8E4U8
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

717231:FLEXSI RS06010
gene id: 717231:FLEXSI_RS06010
uniprot id: F8E6K3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

717231:FLEXSI RS01975
gene id: 717231:FLEXSI_RS01975
uniprot id: F8E8W7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

717231:FLEXSI RS09955
gene id: 717231:FLEXSI_RS09955
uniprot id: F8E4N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

717231:FLEXSI RS08605
gene id: 717231:FLEXSI_RS08605
uniprot id: F8E9L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

717231:FLEXSI RS01135
gene id: 717231:FLEXSI_RS01135
uniprot id: F8E7S8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

717231:FLEXSI RS11955
gene id: 717231:FLEXSI_RS11955
uniprot id: F8E6R7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

717231:FLEXSI RS11870
gene id: 717231:FLEXSI_RS11870
uniprot id: F8E6Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

717231:FLEXSI RS05550
gene id: 717231:FLEXSI_RS05550
uniprot id: F8E647
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

717231:FLEXSI RS00685
gene id: 717231:FLEXSI_RS00685
uniprot id: F8E7B9
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

717231:FLEXSI RS07890
gene id: 717231:FLEXSI_RS07890
uniprot id: F8E8T1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

717231:FLEXSI RS07560
gene id: 717231:FLEXSI_RS07560
uniprot id: F8E8E1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

717231:FLEXSI RS02780
gene id: 717231:FLEXSI_RS02780
uniprot id: F8E9Q5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

717231:FLEXSI RS06440
gene id: 717231:FLEXSI_RS06440
uniprot id: F8E760
names: Subcellular Location Annotation
messages: Membrane

717231:FLEXSI RS09150
gene id: 717231:FLEXSI_RS09150
uniprot id: F8E3T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

717231:FLEXSI RS09660
gene id: 717231:FLEXSI_RS09660
uniprot id: F8E4A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

717231:FLEXSI RS10485
gene id: 717231:FLEXSI_RS10485
uniprot id: F8E553
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.