713585:THITH RS10530
gene id: 713585:THITH_RS10530
uniprot id: W0DN66
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15360
gene id: 713585:THITH_RS15360
uniprot id: W0DR89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

713585:THITH RS02595
gene id: 713585:THITH_RS02595
uniprot id: W0DFF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

713585:THITH RS01745
gene id: 713585:THITH_RS01745
uniprot id: W0DFT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS11760
gene id: 713585:THITH_RS11760
uniprot id: W0DPF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

713585:THITH RS11505
gene id: 713585:THITH_RS11505
uniprot id: W0DPA8
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

713585:THITH RS08400
gene id: 713585:THITH_RS08400
uniprot id: W0DN58
names: Similarity
messages: Belongs to the ABC transporter superfamily.

713585:THITH RS11840
gene id: 713585:THITH_RS11840
uniprot id: W0DNR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

713585:THITH RS06660
gene id: 713585:THITH_RS06660
uniprot id: W0DHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS16045
gene id: 713585:THITH_RS16045
uniprot id: W0DM22
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

713585:THITH RS04385
gene id: 713585:THITH_RS04385
uniprot id: W0DG75
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06825
gene id: 713585:THITH_RS06825
uniprot id: W0DMD3
names: Subcellular Location Annotation
messages: Cytoplasm

713585:THITH RS06050
gene id: 713585:THITH_RS06050
uniprot id: W0DLP9
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

713585:THITH RS00505
gene id: 713585:THITH_RS00505
uniprot id: W0DED9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

713585:THITH RS17170
gene id: 713585:THITH_RS17170
uniprot id: W0DNW2
names: Subcellular Location Annotation
messages: Cell inner membrane

713585:THITH RS03730
gene id: 713585:THITH_RS03730
uniprot id: W0DGN2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

713585:THITH RS01475
gene id: 713585:THITH_RS01475
uniprot id: W0DJX8
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

713585:THITH RS12190
gene id: 713585:THITH_RS12190
uniprot id: W0DQ03
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

713585:THITH RS07850
gene id: 713585:THITH_RS07850
uniprot id: W0DMM5
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

713585:THITH RS13085
gene id: 713585:THITH_RS13085
uniprot id: W0DQF2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

713585:THITH RS09845
gene id: 713585:THITH_RS09845
uniprot id: W0DNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS10025
gene id: 713585:THITH_RS10025
uniprot id: W0DNK5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

713585:THITH RS06360
gene id: 713585:THITH_RS06360
uniprot id: W0DL41
names: Similarity
messages: Belongs to the UPF0234 family.

713585:THITH RS01445
gene id: 713585:THITH_RS01445
uniprot id: W0DJX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

713585:THITH RS03890
gene id: 713585:THITH_RS03890
uniprot id: W0DFY7
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

713585:THITH RS15490
gene id: 713585:THITH_RS15490
uniprot id: W0DRB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

713585:THITH RS13895
gene id: 713585:THITH_RS13895
uniprot id: W0DLE0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

713585:THITH RS15445
gene id: 713585:THITH_RS15445
uniprot id: W0DLP7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

713585:THITH RS03545
gene id: 713585:THITH_RS03545
uniprot id: W0DGL0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

713585:THITH RS05405
gene id: 713585:THITH_RS05405
uniprot id: W0DHD2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS13745
gene id: 713585:THITH_RS13745
uniprot id: W0DLB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS13780
gene id: 713585:THITH_RS13780
uniprot id: W0DQH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

713585:THITH RS07390
gene id: 713585:THITH_RS07390
uniprot id: W0DMR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS09255
gene id: 713585:THITH_RS09255
uniprot id: W0DNK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

713585:THITH RS11200
gene id: 713585:THITH_RS11200
uniprot id: W0DPJ9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

713585:THITH RS11610
gene id: 713585:THITH_RS11610
uniprot id: W0DPC6
names: Similarity
messages: Belongs to the DsrF/TusC family.

713585:THITH RS16200
gene id: 713585:THITH_RS16200
uniprot id: W0DS50
names: Similarity
messages: Belongs to the YciI family.

713585:THITH RS15890
gene id: 713585:THITH_RS15890
uniprot id: W0DRW4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

713585:THITH RS00495
gene id: 713585:THITH_RS00495
uniprot id: W0DIC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

713585:THITH RS07745
gene id: 713585:THITH_RS07745
uniprot id: W0DMW8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

713585:THITH RS15265
gene id: 713585:THITH_RS15265
uniprot id: W0DM10
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

713585:THITH RS14235
gene id: 713585:THITH_RS14235
uniprot id: W0DLJ9
names: Subcellular Location Annotation
messages: Cytoplasm

713585:THITH RS15150
gene id: 713585:THITH_RS15150
uniprot id: W0DQD3
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

713585:THITH RS08025
gene id: 713585:THITH_RS08025
uniprot id: W0DIL7
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

713585:THITH RS08495
gene id: 713585:THITH_RS08495
uniprot id: W0DI91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

713585:THITH RS12550
gene id: 713585:THITH_RS12550
uniprot id: W0DKN0
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

713585:THITH RS12995
gene id: 713585:THITH_RS12995
uniprot id: W0DQ10
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

713585:THITH RS04725
gene id: 713585:THITH_RS04725
uniprot id: W0DL43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

713585:THITH RS12675
gene id: 713585:THITH_RS12675
uniprot id: W0DPW3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

713585:THITH RS07235
gene id: 713585:THITH_RS07235
uniprot id: W0DHM5
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

713585:THITH RS08285
gene id: 713585:THITH_RS08285
uniprot id: W0DM31
names: Similarity
messages: Belongs to the pirin family.

713585:THITH RS14725
gene id: 713585:THITH_RS14725
uniprot id: W0DLR8
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

713585:THITH RS15660
gene id: 713585:THITH_RS15660
uniprot id: W0DLU0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS04220
gene id: 713585:THITH_RS04220
uniprot id: W0DKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

713585:THITH RS12040
gene id: 713585:THITH_RS12040
uniprot id: W0DJZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

713585:THITH RS06830
gene id: 713585:THITH_RS06830
uniprot id: W0DI18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

713585:THITH RS12725
gene id: 713585:THITH_RS12725
uniprot id: W0DKQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS14075
gene id: 713585:THITH_RS14075
uniprot id: W0DLH0
names: Similarity
messages: Belongs to the UPF0102 family.

713585:THITH RS10280
gene id: 713585:THITH_RS10280
uniprot id: W0DNP4
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

713585:THITH RS04780
gene id: 713585:THITH_RS04780
uniprot id: W0DKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

713585:THITH RS00980
gene id: 713585:THITH_RS00980
uniprot id: W0DFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS11800
gene id: 713585:THITH_RS11800
uniprot id: W0DPU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

713585:THITH RS08730
gene id: 713585:THITH_RS08730
uniprot id: W0DIV9
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

713585:THITH RS10080
gene id: 713585:THITH_RS10080
uniprot id: W0DJ09
names: Similarity
messages: Belongs to the skp family.

713585:THITH RS00500
gene id: 713585:THITH_RS00500
uniprot id: W0DJ29
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

713585:THITH RS13620
gene id: 713585:THITH_RS13620
uniprot id: W0DL88
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

713585:THITH RS07930
gene id: 713585:THITH_RS07930
uniprot id: W0DIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

713585:THITH RS10090
gene id: 713585:THITH_RS10090
uniprot id: W0DJH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

713585:THITH RS12545
gene id: 713585:THITH_RS12545
uniprot id: W0DQ62
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS16560
gene id: 713585:THITH_RS16560
uniprot id: W0DMC9
names: Similarity
messages: Belongs to the peptidase S41A family.

713585:THITH RS13500
gene id: 713585:THITH_RS13500
uniprot id: W0DKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

713585:THITH RS11940
gene id: 713585:THITH_RS11940
uniprot id: W0DKD4
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

713585:THITH RS14250
gene id: 713585:THITH_RS14250
uniprot id: W0DQQ0
names: Similarity
messages: Belongs to the thioredoxin family.

713585:THITH RS09990
gene id: 713585:THITH_RS09990
uniprot id: W0DJF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

713585:THITH RS13825
gene id: 713585:THITH_RS13825
uniprot id: W0DPT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

713585:THITH RS07090
gene id: 713585:THITH_RS07090
uniprot id: W0DHJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

713585:THITH RS01265
gene id: 713585:THITH_RS01265
uniprot id: W0DER6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

713585:THITH RS08315
gene id: 713585:THITH_RS08315
uniprot id: W0DI54
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

713585:THITH RS16195
gene id: 713585:THITH_RS16195
uniprot id: W0DM68
names: Similarity
messages: Belongs to the AHA1 family.

713585:THITH RS16520
gene id: 713585:THITH_RS16520
uniprot id: W0DR57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

713585:THITH RS15470
gene id: 713585:THITH_RS15470
uniprot id: W0DLQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS06665
gene id: 713585:THITH_RS06665
uniprot id: W0DL85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

713585:THITH RS05165
gene id: 713585:THITH_RS05165
uniprot id: W0DLM7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

713585:THITH RS01480
gene id: 713585:THITH_RS01480
uniprot id: W0DFR1
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

713585:THITH RS05865
gene id: 713585:THITH_RS05865
uniprot id: W0DGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

713585:THITH RS02405
gene id: 713585:THITH_RS02405
uniprot id: W0DG45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

713585:THITH RS00685
gene id: 713585:THITH_RS00685
uniprot id: W0DF99
names: PTM
messages: Binds 1 heme group per subunit.

713585:THITH RS11650
gene id: 713585:THITH_RS11650
uniprot id: W0DK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

713585:THITH RS09225
gene id: 713585:THITH_RS09225
uniprot id: W0DNK6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

713585:THITH RS06850
gene id: 713585:THITH_RS06850
uniprot id: W0DMD8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

713585:THITH RS12770
gene id: 713585:THITH_RS12770
uniprot id: W0DQA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

713585:THITH RS12640
gene id: 713585:THITH_RS12640
uniprot id: W0DPV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

713585:THITH RS15550
gene id: 713585:THITH_RS15550
uniprot id: W0DLR5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

713585:THITH RS06820
gene id: 713585:THITH_RS06820
uniprot id: W0DHE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

713585:THITH RS15515
gene id: 713585:THITH_RS15515
uniprot id: W0DQK0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

713585:THITH RS04015
gene id: 713585:THITH_RS04015
uniprot id: W0DKQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

713585:THITH RS12660
gene id: 713585:THITH_RS12660
uniprot id: W0DP53
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
messages: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.

713585:THITH RS16440
gene id: 713585:THITH_RS16440
uniprot id: W0DMN7
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

713585:THITH RS13690
gene id: 713585:THITH_RS13690
uniprot id: W0DKW4
names: Similarity
messages: Belongs to the PhoH family.

713585:THITH RS01390
gene id: 713585:THITH_RS01390
uniprot id: W0DEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

713585:THITH RS10505
gene id: 713585:THITH_RS10505
uniprot id: W0DNW5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS01425
gene id: 713585:THITH_RS01425
uniprot id: W0DFQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

713585:THITH RS14020
gene id: 713585:THITH_RS14020
uniprot id: W0DLG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

713585:THITH RS01315
gene id: 713585:THITH_RS01315
uniprot id: W0DES7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Non-allosteric.

713585:THITH RS08110
gene id: 713585:THITH_RS08110
uniprot id: W0DM07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

713585:THITH RS11705
gene id: 713585:THITH_RS11705
uniprot id: W0DNP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

713585:THITH RS11140
gene id: 713585:THITH_RS11140
uniprot id: W0DJZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

713585:THITH RS11850
gene id: 713585:THITH_RS11850
uniprot id: W0DJV8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

713585:THITH RS16755
gene id: 713585:THITH_RS16755
uniprot id: W0DMF4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

713585:THITH RS02025
gene id: 713585:THITH_RS02025
uniprot id: W0DK45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

713585:THITH RS06130
gene id: 713585:THITH_RS06130
uniprot id: W0DH24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

713585:THITH RS07680
gene id: 713585:THITH_RS07680
uniprot id: W0DLU7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

713585:THITH RS06870
gene id: 713585:THITH_RS06870
uniprot id: W0DN59
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06640
gene id: 713585:THITH_RS06640
uniprot id: W0DM02
names: Similarity
messages: Belongs to the universal stress protein A family.

713585:THITH RS02610
gene id: 713585:THITH_RS02610
uniprot id: W0DJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

713585:THITH RS11685
gene id: 713585:THITH_RS11685
uniprot id: W0DPE1
names: Similarity
messages: Belongs to the UPF0434 family.

713585:THITH RS16485
gene id: 713585:THITH_RS16485
uniprot id: W0DS95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

713585:THITH RS14860
gene id: 713585:THITH_RS14860
uniprot id: W0DLT8
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

713585:THITH RS15645
gene id: 713585:THITH_RS15645
uniprot id: W0DM75
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

713585:THITH RS14185
gene id: 713585:THITH_RS14185
uniprot id: W0DPZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

713585:THITH RS16605
gene id: 713585:THITH_RS16605
uniprot id: W0DRY7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

713585:THITH RS02635
gene id: 713585:THITH_RS02635
uniprot id: W0DJF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

713585:THITH RS10990
gene id: 713585:THITH_RS10990
uniprot id: W0DP31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

713585:THITH RS02650
gene id: 713585:THITH_RS02650
uniprot id: W0DKF5
names: Similarity
messages: Belongs to the peptidase S49 family.

713585:THITH RS01180
gene id: 713585:THITH_RS01180
uniprot id: W0DEP9
names: Similarity
messages: Belongs to the phosphoribulokinase family.

713585:THITH RS08475
gene id: 713585:THITH_RS08475
uniprot id: W0DN72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

713585:THITH RS06475
gene id: 713585:THITH_RS06475
uniprot id: W0DLX2
names: Similarity
messages: Belongs to the transglycosylase Slt family.

713585:THITH RS00295
gene id: 713585:THITH_RS00295
uniprot id: W0DEA1
names: Similarity
messages: Belongs to the UPF0175 family.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS12745
gene id: 713585:THITH_RS12745
uniprot id: W0DQ98
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

713585:THITH RS09645
gene id: 713585:THITH_RS09645
uniprot id: W0DJ97
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

713585:THITH RS02525
gene id: 713585:THITH_RS02525
uniprot id: W0DKC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

713585:THITH RS06605
gene id: 713585:THITH_RS06605
uniprot id: W0DHX6
names: Similarity
messages: Belongs to the HupF/HypC family.

713585:THITH RS08465
gene id: 713585:THITH_RS08465
uniprot id: W0DMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

713585:THITH RS14355
gene id: 713585:THITH_RS14355
uniprot id: W0DQ17
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

713585:THITH RS13875
gene id: 713585:THITH_RS13875
uniprot id: W0DPU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

713585:THITH RS14000
gene id: 713585:THITH_RS14000
uniprot id: W0DPW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

713585:THITH RS06630
gene id: 713585:THITH_RS06630
uniprot id: W0DHY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
messages: Monomer.

713585:THITH RS09735
gene id: 713585:THITH_RS09735
uniprot id: W0DJB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

713585:THITH RS13075
gene id: 713585:THITH_RS13075
uniprot id: W0DQ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

713585:THITH RS12600
gene id: 713585:THITH_RS12600
uniprot id: W0DQ74
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

713585:THITH RS10995
gene id: 713585:THITH_RS10995
uniprot id: W0DJH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS07670
gene id: 713585:THITH_RS07670
uniprot id: W0DNL2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS11695
gene id: 713585:THITH_RS11695
uniprot id: W0DPS7
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15510
gene id: 713585:THITH_RS15510
uniprot id: W0DM52
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

713585:THITH RS14005
gene id: 713585:THITH_RS14005
uniprot id: W0DQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

713585:THITH RS01910
gene id: 713585:THITH_RS01910
uniprot id: W0DF38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS06905
gene id: 713585:THITH_RS06905
uniprot id: W0DM50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.
messages: The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).

713585:THITH RS14140
gene id: 713585:THITH_RS14140
uniprot id: W0DL38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS12500
gene id: 713585:THITH_RS12500
uniprot id: W0DP20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

713585:THITH RS05105
gene id: 713585:THITH_RS05105
uniprot id: W0DLA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

713585:THITH RS00910
gene id: 713585:THITH_RS00910
uniprot id: W0DII6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

713585:THITH RS13585
gene id: 713585:THITH_RS13585
uniprot id: W0DQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

713585:THITH RS00890
gene id: 713585:THITH_RS00890
uniprot id: W0DJ93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

713585:THITH RS01010
gene id: 713585:THITH_RS01010
uniprot id: W0DEM1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

713585:THITH RS03680
gene id: 713585:THITH_RS03680
uniprot id: W0DJV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

713585:THITH RS00395
gene id: 713585:THITH_RS00395
uniprot id: W0DIA2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

713585:THITH RS12405
gene id: 713585:THITH_RS12405
uniprot id: W0DNZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

713585:THITH RS16650
gene id: 713585:THITH_RS16650
uniprot id: W0DMR6
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

713585:THITH RS03915
gene id: 713585:THITH_RS03915
uniprot id: W0DFZ1
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

713585:THITH RS01220
gene id: 713585:THITH_RS01220
uniprot id: W0DIP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

713585:THITH RS03955
gene id: 713585:THITH_RS03955
uniprot id: W0DGS0
names: Similarity
messages: Belongs to the CFA/CMAS family.

713585:THITH RS13015
gene id: 713585:THITH_RS13015
uniprot id: W0DPB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

713585:THITH RS07105
gene id: 713585:THITH_RS07105
uniprot id: W0DLG6
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

713585:THITH RS11105
gene id: 713585:THITH_RS11105
uniprot id: W0DPI8
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

713585:THITH RS13830
gene id: 713585:THITH_RS13830
uniprot id: W0DQI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

713585:THITH RS12515
gene id: 713585:THITH_RS12515
uniprot id: W0DK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

713585:THITH RS10355
gene id: 713585:THITH_RS10355
uniprot id: W0DP33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

713585:THITH RS04300
gene id: 713585:THITH_RS04300
uniprot id: W0DKV0
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS16960
gene id: 713585:THITH_RS16960
uniprot id: W0DMH9
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

713585:THITH RS00425
gene id: 713585:THITH_RS00425
uniprot id: W0DIA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

713585:THITH RS11700
gene id: 713585:THITH_RS11700
uniprot id: W0DK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

713585:THITH RS02855
gene id: 713585:THITH_RS02855
uniprot id: W0DFJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

713585:THITH RS16970
gene id: 713585:THITH_RS16970
uniprot id: W0DMW6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS04655
gene id: 713585:THITH_RS04655
uniprot id: W0DL34
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

713585:THITH RS11445
gene id: 713585:THITH_RS11445
uniprot id: W0DNK2
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

713585:THITH RS16060
gene id: 713585:THITH_RS16060
uniprot id: W0DQW2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

713585:THITH RS04265
gene id: 713585:THITH_RS04265
uniprot id: W0DK63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

713585:THITH RS00105
gene id: 713585:THITH_RS00105
uniprot id: W0DF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS03690
gene id: 713585:THITH_RS03690
uniprot id: W0DFV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

713585:THITH RS04765
gene id: 713585:THITH_RS04765
uniprot id: W0DGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

713585:THITH RS05855
gene id: 713585:THITH_RS05855
uniprot id: W0DKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

713585:THITH RS07465
gene id: 713585:THITH_RS07465
uniprot id: W0DMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

713585:THITH RS12840
gene id: 713585:THITH_RS12840
uniprot id: W0DP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

713585:THITH RS03900
gene id: 713585:THITH_RS03900
uniprot id: W0DGR0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

713585:THITH RS14495
gene id: 713585:THITH_RS14495
uniprot id: W0DQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

713585:THITH RS07280
gene id: 713585:THITH_RS07280
uniprot id: W0DIA6
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

713585:THITH RS04315
gene id: 713585:THITH_RS04315
uniprot id: W0DGX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

713585:THITH RS03415
gene id: 713585:THITH_RS03415
uniprot id: W0DJR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

713585:THITH RS11045
gene id: 713585:THITH_RS11045
uniprot id: W0DJI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

713585:THITH RS07855
gene id: 713585:THITH_RS07855
uniprot id: W0DHZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

713585:THITH RS05545
gene id: 713585:THITH_RS05545
uniprot id: W0DKT1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

713585:THITH RS06030
gene id: 713585:THITH_RS06030
uniprot id: W0DM09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

713585:THITH RS06835
gene id: 713585:THITH_RS06835
uniprot id: W0DLB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

713585:THITH RS04230
gene id: 713585:THITH_RS04230
uniprot id: W0DL51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

713585:THITH RS00930
gene id: 713585:THITH_RS00930
uniprot id: W0DFE1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

713585:THITH RS01400
gene id: 713585:THITH_RS01400
uniprot id: W0DFP6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS11255
gene id: 713585:THITH_RS11255
uniprot id: W0DNH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

713585:THITH RS09060
gene id: 713585:THITH_RS09060
uniprot id: W0DJ11
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

713585:THITH RS15980
gene id: 713585:THITH_RS15980
uniprot id: W0DME0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane

713585:THITH RS16280
gene id: 713585:THITH_RS16280
uniprot id: W0DS65
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

713585:THITH RS13050
gene id: 713585:THITH_RS13050
uniprot id: W0DQ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

713585:THITH RS03400
gene id: 713585:THITH_RS03400
uniprot id: W0DFQ4
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

713585:THITH RS07065
gene id: 713585:THITH_RS07065
uniprot id: W0DHJ2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

713585:THITH RS14180
gene id: 713585:THITH_RS14180
uniprot id: W0DLI9
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

713585:THITH RS16795
gene id: 713585:THITH_RS16795
uniprot id: W0DR97
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03185
gene id: 713585:THITH_RS03185
uniprot id: W0DKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

713585:THITH RS14810
gene id: 713585:THITH_RS14810
uniprot id: W0DQ85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

713585:THITH RS00435
gene id: 713585:THITH_RS00435
uniprot id: W0DEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

713585:THITH RS07130
gene id: 713585:THITH_RS07130
uniprot id: W0DI74
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

713585:THITH RS07415
gene id: 713585:THITH_RS07415
uniprot id: W0DMR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

713585:THITH RS04800
gene id: 713585:THITH_RS04800
uniprot id: W0DH47
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS11370
gene id: 713585:THITH_RS11370
uniprot id: W0DPM3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS13495
gene id: 713585:THITH_RS13495
uniprot id: W0DQD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS02090
gene id: 713585:THITH_RS02090
uniprot id: W0DJV5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

713585:THITH RS16720
gene id: 713585:THITH_RS16720
uniprot id: W0DS02
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

713585:THITH RS10385
gene id: 713585:THITH_RS10385
uniprot id: W0DJL1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS01280
gene id: 713585:THITH_RS01280
uniprot id: W0DIR0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

713585:THITH RS00420
gene id: 713585:THITH_RS00420
uniprot id: W0DF50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

713585:THITH RS03535
gene id: 713585:THITH_RS03535
uniprot id: W0DFS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

713585:THITH RS12470
gene id: 713585:THITH_RS12470
uniprot id: W0DKL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

713585:THITH RS16145
gene id: 713585:THITH_RS16145
uniprot id: W0DMI0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

713585:THITH RS07955
gene id: 713585:THITH_RS07955
uniprot id: W0DIK9
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS03920
gene id: 713585:THITH_RS03920
uniprot id: W0DKZ6
names: Caution
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

713585:THITH RS14545
gene id: 713585:THITH_RS14545
uniprot id: W0DQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

713585:THITH RS05860
gene id: 713585:THITH_RS05860
uniprot id: W0DLL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

713585:THITH RS02410
gene id: 713585:THITH_RS02410
uniprot id: W0DJB1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

713585:THITH RS10480
gene id: 713585:THITH_RS10480
uniprot id: W0DNW0
names: Similarity
messages: Belongs to the asparagine synthetase family.

713585:THITH RS09890
gene id: 713585:THITH_RS09890
uniprot id: W0DNV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

713585:THITH RS10690
gene id: 713585:THITH_RS10690
uniprot id: W0DJD7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS00900
gene id: 713585:THITH_RS00900
uniprot id: W0DJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS14390
gene id: 713585:THITH_RS14390
uniprot id: W0DQS5
names: Similarity
messages: Belongs to the BolA/IbaG family.

713585:THITH RS12215
gene id: 713585:THITH_RS12215
uniprot id: W0DSJ1
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS13435
gene id: 713585:THITH_RS13435
uniprot id: W0DPL7
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

713585:THITH RS00150
gene id: 713585:THITH_RS00150
uniprot id: W0DE81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

713585:THITH RS07445
gene id: 713585:THITH_RS07445
uniprot id: W0DIF1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

713585:THITH RS16510
gene id: 713585:THITH_RS16510
uniprot id: W0DS99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

713585:THITH RS00475
gene id: 713585:THITH_RS00475
uniprot id: W0DJ23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

713585:THITH RS02200
gene id: 713585:THITH_RS02200
uniprot id: W0DJ80
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

713585:THITH RS13255
gene id: 713585:THITH_RS13255
uniprot id: W0DQ66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

713585:THITH RS12555
gene id: 713585:THITH_RS12555
uniprot id: W0DP32
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

713585:THITH RS05895
gene id: 713585:THITH_RS05895
uniprot id: W0DLY4
names: Cofactor
messages: Can also use Mn(2+) ion.

713585:THITH RS14310
gene id: 713585:THITH_RS14310
uniprot id: W0DR48
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

713585:THITH RS13120
gene id: 713585:THITH_RS13120
uniprot id: W0DPD3
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS04240
gene id: 713585:THITH_RS04240
uniprot id: W0DK58
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

713585:THITH RS11235
gene id: 713585:THITH_RS11235
uniprot id: W0DSG9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

713585:THITH RS13760
gene id: 713585:THITH_RS13760
uniprot id: W0DKX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

713585:THITH RS12490
gene id: 713585:THITH_RS12490
uniprot id: W0DQ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

713585:THITH RS06540
gene id: 713585:THITH_RS06540
uniprot id: W0DM87
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

713585:THITH RS02585
gene id: 713585:THITH_RS02585
uniprot id: W0DJE2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS10250
gene id: 713585:THITH_RS10250
uniprot id: W0DMX9
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

713585:THITH RS04660
gene id: 713585:THITH_RS04660
uniprot id: W0DGE9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

713585:THITH RS15425
gene id: 713585:THITH_RS15425
uniprot id: W0DRN4
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS14505
gene id: 713585:THITH_RS14505
uniprot id: W0DL94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

713585:THITH RS09080
gene id: 713585:THITH_RS09080
uniprot id: W0DII4
names: Similarity
messages: Belongs to the aspartokinase family.

713585:THITH RS07440
gene id: 713585:THITH_RS07440
uniprot id: W0DMS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

713585:THITH RS12805
gene id: 713585:THITH_RS12805
uniprot id: W0DKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

713585:THITH RS00885
gene id: 713585:THITH_RS00885
uniprot id: W0DIH9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

713585:THITH RS13785
gene id: 713585:THITH_RS13785
uniprot id: W0DKY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS03630
gene id: 713585:THITH_RS03630
uniprot id: W0DFU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

713585:THITH RS14350
gene id: 713585:THITH_RS14350
uniprot id: W0DLL8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

713585:THITH RS15880
gene id: 713585:THITH_RS15880
uniprot id: W0DRI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS00570
gene id: 713585:THITH_RS00570
uniprot id: W0DID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

713585:THITH RS14105
gene id: 713585:THITH_RS14105
uniprot id: W0DPX9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

713585:THITH RS09695
gene id: 713585:THITH_RS09695
uniprot id: W0DNS7
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS13815
gene id: 713585:THITH_RS13815
uniprot id: W0DQW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

713585:THITH RS04350
gene id: 713585:THITH_RS04350
uniprot id: W0DK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS00035
gene id: 713585:THITH_RS00035
uniprot id: W0DEZ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

713585:THITH RS06845
gene id: 713585:THITH_RS06845
uniprot id: W0DHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

713585:THITH RS09275
gene id: 713585:THITH_RS09275
uniprot id: W0DIM6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15560
gene id: 713585:THITH_RS15560
uniprot id: W0DM62
names: Similarity
messages: Belongs to the GSP E family.

713585:THITH RS02135
gene id: 713585:THITH_RS02135
uniprot id: W0DJ73
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS01350
gene id: 713585:THITH_RS01350
uniprot id: W0DFM1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

713585:THITH RS14475
gene id: 713585:THITH_RS14475
uniprot id: W0DQT9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS07085
gene id: 713585:THITH_RS07085
uniprot id: W0DM84
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

713585:THITH RS12245
gene id: 713585:THITH_RS12245
uniprot id: W0DK32
names: Similarity
messages: Belongs to the AlaDH/PNT family.

713585:THITH RS11535
gene id: 713585:THITH_RS11535
uniprot id: W0DPB2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

713585:THITH RS15680
gene id: 713585:THITH_RS15680
uniprot id: W0DRE8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

713585:THITH RS00145
gene id: 713585:THITH_RS00145
uniprot id: W0DSH1
names: Similarity
messages: Belongs to the GSP C family.

713585:THITH RS10405
gene id: 713585:THITH_RS10405
uniprot id: W0DJ62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

713585:THITH RS03490
gene id: 713585:THITH_RS03490
uniprot id: W0DGK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

713585:THITH RS10905
gene id: 713585:THITH_RS10905
uniprot id: W0DP17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

713585:THITH RS06895
gene id: 713585:THITH_RS06895
uniprot id: W0DI26
names: Similarity
messages: Belongs to the RecA family.

713585:THITH RS13795
gene id: 713585:THITH_RS13795
uniprot id: W0DLB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

713585:THITH RS06960
gene id: 713585:THITH_RS06960
uniprot id: W0DHH0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

713585:THITH RS13555
gene id: 713585:THITH_RS13555
uniprot id: W0DKU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

713585:THITH RS06035
gene id: 713585:THITH_RS06035
uniprot id: W0DHM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

713585:THITH RS12730
gene id: 713585:THITH_RS12730
uniprot id: W0DP64
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

713585:THITH RS14025
gene id: 713585:THITH_RS14025
uniprot id: W0DPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

713585:THITH RS16055
gene id: 713585:THITH_RS16055
uniprot id: W0DMF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

713585:THITH RS15855
gene id: 713585:THITH_RS15855
uniprot id: W0DRI0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

713585:THITH RS01660
gene id: 713585:THITH_RS01660
uniprot id: W0DJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

713585:THITH RS00310
gene id: 713585:THITH_RS00310
uniprot id: W0DF33
names: Similarity
messages: Belongs to the CcdB toxin family.

713585:THITH RS09075
gene id: 713585:THITH_RS09075
uniprot id: W0DN67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

713585:THITH RS14855
gene id: 713585:THITH_RS14855
uniprot id: W0DRD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

713585:THITH RS16430
gene id: 713585:THITH_RS16430
uniprot id: W0DMA5
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

713585:THITH RS02735
gene id: 713585:THITH_RS02735
uniprot id: W0DKH0
names: Similarity
messages: Belongs to the acylphosphatase family.

713585:THITH RS01165
gene id: 713585:THITH_RS01165
uniprot id: W0DFH7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS16225
gene id: 713585:THITH_RS16225
uniprot id: W0DM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

713585:THITH RS00600
gene id: 713585:THITH_RS00600
uniprot id: W0DJ51
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

713585:THITH RS09760
gene id: 713585:THITH_RS09760
uniprot id: W0DIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

713585:THITH RS06635
gene id: 713585:THITH_RS06635
uniprot id: W0DL81
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

713585:THITH RS01930
gene id: 713585:THITH_RS01930
uniprot id: W0DJT0
names: Similarity
messages: Belongs to the AlaDH/PNT family.

713585:THITH RS11575
gene id: 713585:THITH_RS11575
uniprot id: W0DK72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

713585:THITH RS08790
gene id: 713585:THITH_RS08790
uniprot id: W0DIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

713585:THITH RS02150
gene id: 713585:THITH_RS02150
uniprot id: W0DK69
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS02615
gene id: 713585:THITH_RS02615
uniprot id: W0DK46
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

713585:THITH RS03465
gene id: 713585:THITH_RS03465
uniprot id: W0DGJ8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

713585:THITH RS14120
gene id: 713585:THITH_RS14120
uniprot id: W0DR16
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

713585:THITH RS02715
gene id: 713585:THITH_RS02715
uniprot id: W0DG95
names: Similarity
messages: Belongs to the DnaA family.

713585:THITH RS11415
gene id: 713585:THITH_RS11415
uniprot id: W0DNJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS13765
gene id: 713585:THITH_RS13765
uniprot id: W0DQV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

713585:THITH RS16505
gene id: 713585:THITH_RS16505
uniprot id: W0DMB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

713585:THITH RS08735
gene id: 713585:THITH_RS08735
uniprot id: W0DM96
names: Similarity
messages: Belongs to the peptidase M17 family.

713585:THITH RS01020
gene id: 713585:THITH_RS01020
uniprot id: W0DJM8
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

713585:THITH RS12610
gene id: 713585:THITH_RS12610
uniprot id: W0DP43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

713585:THITH RS09160
gene id: 713585:THITH_RS09160
uniprot id: W0DJ30
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

713585:THITH RS07775
gene id: 713585:THITH_RS07775
uniprot id: W0DII9
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

713585:THITH RS07325
gene id: 713585:THITH_RS07325
uniprot id: W0DHP2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS09265
gene id: 713585:THITH_RS09265
uniprot id: W0DMH8
names: Similarity
messages: Belongs to the YciI family.

713585:THITH RS03830
gene id: 713585:THITH_RS03830
uniprot id: W0DKY4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

713585:THITH RS13985
gene id: 713585:THITH_RS13985
uniprot id: W0DL14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

713585:THITH RS05090
gene id: 713585:THITH_RS05090
uniprot id: W0DKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

713585:THITH RS11540
gene id: 713585:THITH_RS11540
uniprot id: W0DJQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

713585:THITH RS14130
gene id: 713585:THITH_RS14130
uniprot id: W0DPY3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

713585:THITH RS00985
gene id: 713585:THITH_RS00985
uniprot id: W0DIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS05950
gene id: 713585:THITH_RS05950
uniprot id: W0DHL2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

713585:THITH RS09725
gene id: 713585:THITH_RS09725
uniprot id: W0DIV0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

713585:THITH RS08950
gene id: 713585:THITH_RS08950
uniprot id: W0DIG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

713585:THITH RS11625
gene id: 713585:THITH_RS11625
uniprot id: W0DK82
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15275
gene id: 713585:THITH_RS15275
uniprot id: W0DR71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

713585:THITH RS02470
gene id: 713585:THITH_RS02470
uniprot id: W0DFD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

713585:THITH RS00210
gene id: 713585:THITH_RS00210
uniprot id: W0DMJ2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS05120
gene id: 713585:THITH_RS05120
uniprot id: W0DH91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

713585:THITH RS09985
gene id: 713585:THITH_RS09985
uniprot id: W0DNW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS13560
gene id: 713585:THITH_RS13560
uniprot id: W0DQS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

713585:THITH RS02440
gene id: 713585:THITH_RS02440
uniprot id: W0DK19
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS11605
gene id: 713585:THITH_RS11605
uniprot id: W0DNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

713585:THITH RS16435
gene id: 713585:THITH_RS16435
uniprot id: W0DS85
names: Similarity
messages: Belongs to the RutC family.

713585:THITH RS16760
gene id: 713585:THITH_RS16760
uniprot id: W0DSD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

713585:THITH RS01360
gene id: 713585:THITH_RS01360
uniprot id: W0DJJ1
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

713585:THITH RS16595
gene id: 713585:THITH_RS16595
uniprot id: W0DMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

713585:THITH RS15465
gene id: 713585:THITH_RS15465
uniprot id: W0DRA9
names: Similarity
messages: Belongs to the pyruvate kinase family.

713585:THITH RS06610
gene id: 713585:THITH_RS06610
uniprot id: W0DL77
names: Similarity
messages: Belongs to the HypD family.

713585:THITH RS15730
gene id: 713585:THITH_RS15730
uniprot id: W0DRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS03540
gene id: 713585:THITH_RS03540
uniprot id: W0DKU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

713585:THITH RS11950
gene id: 713585:THITH_RS11950
uniprot id: W0DPI6
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

713585:THITH RS14450
gene id: 713585:THITH_RS14450
uniprot id: W0DQT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

713585:THITH RS07890
gene id: 713585:THITH_RS07890
uniprot id: W0DHZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS00065
gene id: 713585:THITH_RS00065
uniprot id: W0DI44
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

713585:THITH RS13070
gene id: 713585:THITH_RS13070
uniprot id: W0DPC3
names: Similarity
messages: Belongs to the thioredoxin family.

713585:THITH RS07175
gene id: 713585:THITH_RS07175
uniprot id: W0DM99
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

713585:THITH RS05310
gene id: 713585:THITH_RS05310
uniprot id: W0DKQ0
names: Similarity
messages: Belongs to the UPF0178 family.

713585:THITH RS06585
gene id: 713585:THITH_RS06585
uniprot id: W0DLZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15255
gene id: 713585:THITH_RS15255
uniprot id: W0DLL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS11145
gene id: 713585:THITH_RS11145
uniprot id: W0DNF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

713585:THITH RS03775
gene id: 713585:THITH_RS03775
uniprot id: W0DFX3
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS08665
gene id: 713585:THITH_RS08665
uniprot id: W0DIB7
names: Similarity
messages: Belongs to the glutamate synthase family.

713585:THITH RS08750
gene id: 713585:THITH_RS08750
uniprot id: W0DNC9
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06340
gene id: 713585:THITH_RS06340
uniprot id: W0DLU9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS09145
gene id: 713585:THITH_RS09145
uniprot id: W0DMG2
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

713585:THITH RS08655
gene id: 713585:THITH_RS08655
uniprot id: W0DM80
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

713585:THITH RS13700
gene id: 713585:THITH_RS13700
uniprot id: W0DLA2
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS13480
gene id: 713585:THITH_RS13480
uniprot id: W0DL69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

713585:THITH RS06020
gene id: 713585:THITH_RS06020
uniprot id: W0DLP3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

713585:THITH RS13850
gene id: 713585:THITH_RS13850
uniprot id: W0DPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

713585:THITH RS12720
gene id: 713585:THITH_RS12720
uniprot id: W0DQ93
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

713585:THITH RS01160
gene id: 713585:THITH_RS01160
uniprot id: W0DJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

713585:THITH RS07135
gene id: 713585:THITH_RS07135
uniprot id: W0DLH3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

713585:THITH RS09335
gene id: 713585:THITH_RS09335
uniprot id: W0DNM4
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS03725
gene id: 713585:THITH_RS03725
uniprot id: W0DKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

713585:THITH RS03435
gene id: 713585:THITH_RS03435
uniprot id: W0DKR9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

713585:THITH RS10440
gene id: 713585:THITH_RS10440
uniprot id: W0DP63
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS16305
gene id: 713585:THITH_RS16305
uniprot id: W0DM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

713585:THITH RS02345
gene id: 713585:THITH_RS02345
uniprot id: W0DFA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

713585:THITH RS14245
gene id: 713585:THITH_RS14245
uniprot id: W0DPZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

713585:THITH RS10295
gene id: 713585:THITH_RS10295
uniprot id: W0DP18
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

713585:THITH RS15115
gene id: 713585:THITH_RS15115
uniprot id: W0DRH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

713585:THITH RS12620
gene id: 713585:THITH_RS12620
uniprot id: W0DKA1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

713585:THITH RS09110
gene id: 713585:THITH_RS09110
uniprot id: W0DNI8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

713585:THITH RS13820
gene id: 713585:THITH_RS13820
uniprot id: W0DLC4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

713585:THITH RS08510
gene id: 713585:THITH_RS08510
uniprot id: W0DM61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS03280
gene id: 713585:THITH_RS03280
uniprot id: W0DGH1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

713585:THITH RS02750
gene id: 713585:THITH_RS02750
uniprot id: W0DK68
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS04935
gene id: 713585:THITH_RS04935
uniprot id: W0DKK0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

713585:THITH RS09395
gene id: 713585:THITH_RS09395
uniprot id: W0DNC4
names: Similarity
messages: Belongs to the citrate synthase family.

713585:THITH RS11520
gene id: 713585:THITH_RS11520
uniprot id: W0DK61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS07510
gene id: 713585:THITH_RS07510
uniprot id: W0DMT1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

713585:THITH RS15570
gene id: 713585:THITH_RS15570
uniprot id: W0DRC8
names: Similarity
messages: Belongs to the GSP E family.

713585:THITH RS05995
gene id: 713585:THITH_RS05995
uniprot id: W0DLN9
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06070
gene id: 713585:THITH_RS06070
uniprot id: W0DL04
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

713585:THITH RS08260
gene id: 713585:THITH_RS08260
uniprot id: W0DMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

713585:THITH RS06545
gene id: 713585:THITH_RS06545
uniprot id: W0DHW0
names: Similarity
messages: Belongs to the HupH/HyaF family.

713585:THITH RS16490
gene id: 713585:THITH_RS16490
uniprot id: W0DMP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

713585:THITH RS06785
gene id: 713585:THITH_RS06785
uniprot id: W0DLA4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

713585:THITH RS06115
gene id: 713585:THITH_RS06115
uniprot id: W0DHP4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

713585:THITH RS04925
gene id: 713585:THITH_RS04925
uniprot id: W0DLJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS09870
gene id: 713585:THITH_RS09870
uniprot id: W0DJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

713585:THITH RS12530
gene id: 713585:THITH_RS12530
uniprot id: W0DP26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS09085
gene id: 713585:THITH_RS09085
uniprot id: W0DNI3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

713585:THITH RS02730
gene id: 713585:THITH_RS02730
uniprot id: W0DFH5
names: Similarity
messages: Belongs to the ArsC family.

713585:THITH RS12940
gene id: 713585:THITH_RS12940
uniprot id: W0DKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

713585:THITH RS16545
gene id: 713585:THITH_RS16545
uniprot id: W0DNZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

713585:THITH RS03805
gene id: 713585:THITH_RS03805
uniprot id: W0DFX7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS04260
gene id: 713585:THITH_RS04260
uniprot id: W0DGX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

713585:THITH RS11435
gene id: 713585:THITH_RS11435
uniprot id: W0DPN2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

713585:THITH RS01915
gene id: 713585:THITH_RS01915
uniprot id: W0DK30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

713585:THITH RS16710
gene id: 713585:THITH_RS16710
uniprot id: W0DMS6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

713585:THITH RS00405
gene id: 713585:THITH_RS00405
uniprot id: W0DEB8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

713585:THITH RS13940
gene id: 713585:THITH_RS13940
uniprot id: W0DLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS06230
gene id: 713585:THITH_RS06230
uniprot id: W0DL23
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

713585:THITH RS13715
gene id: 713585:THITH_RS13715
uniprot id: W0DKW9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

713585:THITH RS02995
gene id: 713585:THITH_RS02995
uniprot id: W0DGD3
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

713585:THITH RS13105
gene id: 713585:THITH_RS13105
uniprot id: W0DKI9
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS07300
gene id: 713585:THITH_RS07300
uniprot id: W0DMM3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS07185
gene id: 713585:THITH_RS07185
uniprot id: W0DMJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

713585:THITH RS05870
gene id: 713585:THITH_RS05870
uniprot id: W0DLX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

713585:THITH RS14870
gene id: 713585:THITH_RS14870
uniprot id: W0DR00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

713585:THITH RS12535
gene id: 713585:THITH_RS12535
uniprot id: W0DPT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS11620
gene id: 713585:THITH_RS11620
uniprot id: W0DPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

713585:THITH RS12765
gene id: 713585:THITH_RS12765
uniprot id: W0DKC7
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

713585:THITH RS16600
gene id: 713585:THITH_RS16600
uniprot id: W0DR69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

713585:THITH RS13025
gene id: 713585:THITH_RS13025
uniprot id: W0DQ16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

713585:THITH RS09040
gene id: 713585:THITH_RS09040
uniprot id: W0DS46
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

713585:THITH RS09580
gene id: 713585:THITH_RS09580
uniprot id: W0DIS9
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

713585:THITH RS02000
gene id: 713585:THITH_RS02000
uniprot id: W0DK42
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

713585:THITH RS12520
gene id: 713585:THITH_RS12520
uniprot id: W0DQ58
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS07245
gene id: 713585:THITH_RS07245
uniprot id: W0DI99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

713585:THITH RS14335
gene id: 713585:THITH_RS14335
uniprot id: W0DL67
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

713585:THITH RS02640
gene id: 713585:THITH_RS02640
uniprot id: W0DK50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

713585:THITH RS13210
gene id: 713585:THITH_RS13210
uniprot id: W0DKL3
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

713585:THITH RS16745
gene id: 713585:THITH_RS16745
uniprot id: W0DS08
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15665
gene id: 713585:THITH_RS15665
uniprot id: W0DRS6
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

713585:THITH RS08430
gene id: 713585:THITH_RS08430
uniprot id: W0DIR3
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

713585:THITH RS15225
gene id: 713585:THITH_RS15225
uniprot id: W0DM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

713585:THITH RS15495
gene id: 713585:THITH_RS15495
uniprot id: W0DLQ6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

713585:THITH RS04270
gene id: 713585:THITH_RS04270
uniprot id: W0DKU5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS11755
gene id: 713585:THITH_RS11755
uniprot id: W0DNQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

713585:THITH RS16065
gene id: 713585:THITH_RS16065
uniprot id: W0DRN0
names: Subcellular Location Annotation
messages: Mitochondrion

713585:THITH RS12905
gene id: 713585:THITH_RS12905
uniprot id: W0DP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

713585:THITH RS10425
gene id: 713585:THITH_RS10425
uniprot id: W0DNS4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS01310
gene id: 713585:THITH_RS01310
uniprot id: W0DJH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

713585:THITH RS13185
gene id: 713585:THITH_RS13185
uniprot id: W0DKK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

713585:THITH RS15535
gene id: 713585:THITH_RS15535
uniprot id: W0DM58
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

713585:THITH RS12410
gene id: 713585:THITH_RS12410
uniprot id: W0DK60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

713585:THITH RS02105
gene id: 713585:THITH_RS02105
uniprot id: W0DFZ0
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

713585:THITH RS13805
gene id: 713585:THITH_RS13805
uniprot id: W0DQI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS14135
gene id: 713585:THITH_RS14135
uniprot id: W0DQN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

713585:THITH RS15860
gene id: 713585:THITH_RS15860
uniprot id: W0DLY1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

713585:THITH RS12155
gene id: 713585:THITH_RS12155
uniprot id: W0DPZ9
names: Similarity
messages: Belongs to the UPF0229 family.

713585:THITH RS15405
gene id: 713585:THITH_RS15405
uniprot id: W0DM33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

713585:THITH RS06625
gene id: 713585:THITH_RS06625
uniprot id: W0DMA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS13010
gene id: 713585:THITH_RS13010
uniprot id: W0DKV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

713585:THITH RS13800
gene id: 713585:THITH_RS13800
uniprot id: W0DPT3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

713585:THITH RS00075
gene id: 713585:THITH_RS00075
uniprot id: W0DE71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

713585:THITH RS10415
gene id: 713585:THITH_RS10415
uniprot id: W0DJL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

713585:THITH RS00005
gene id: 713585:THITH_RS00005
uniprot id: W0DEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

713585:THITH RS15145
gene id: 713585:THITH_RS15145
uniprot id: W0DLY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

713585:THITH RS14260
gene id: 713585:THITH_RS14260
uniprot id: W0DR41
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS14880
gene id: 713585:THITH_RS14880
uniprot id: W0DLE8
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

713585:THITH RS01395
gene id: 713585:THITH_RS01395
uniprot id: W0DJW7
names: Similarity
messages: Belongs to the thioredoxin family.

713585:THITH RS09640
gene id: 713585:THITH_RS09640
uniprot id: W0DNR7
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS01170
gene id: 713585:THITH_RS01170
uniprot id: W0DIN5
names: Similarity
messages: Belongs to the universal stress protein A family.

713585:THITH RS15530
gene id: 713585:THITH_RS15530
uniprot id: W0DRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

713585:THITH RS16645
gene id: 713585:THITH_RS16645
uniprot id: W0DSB7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

713585:THITH RS16025
gene id: 713585:THITH_RS16025
uniprot id: W0DRZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

713585:THITH RS11305
gene id: 713585:THITH_RS11305
uniprot id: W0DNI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

713585:THITH RS09130
gene id: 713585:THITH_RS09130
uniprot id: W0DIJ5
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

713585:THITH RS11215
gene id: 713585:THITH_RS11215
uniprot id: W0DNG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

713585:THITH RS13580
gene id: 713585:THITH_RS13580
uniprot id: W0DKU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

713585:THITH RS16925
gene id: 713585:THITH_RS16925
uniprot id: W0DRB2
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

713585:THITH RS11340
gene id: 713585:THITH_RS11340
uniprot id: W0DJM3
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

713585:THITH RS13615
gene id: 713585:THITH_RS13615
uniprot id: W0DQT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

713585:THITH RS00520
gene id: 713585:THITH_RS00520
uniprot id: W0DIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

713585:THITH RS11490
gene id: 713585:THITH_RS11490
uniprot id: W0DPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

713585:THITH RS10710
gene id: 713585:THITH_RS10710
uniprot id: W0DN91
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

713585:THITH RS08810
gene id: 713585:THITH_RS08810
uniprot id: W0DND8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

713585:THITH RS10020
gene id: 713585:THITH_RS10020
uniprot id: W0DMT8
names: Subunit
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

713585:THITH RS13355
gene id: 713585:THITH_RS13355
uniprot id: W0DL49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

713585:THITH RS02485
gene id: 713585:THITH_RS02485
uniprot id: W0DJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS04310
gene id: 713585:THITH_RS04310
uniprot id: W0DL68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

713585:THITH RS12760
gene id: 713585:THITH_RS12760
uniprot id: W0DPX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

713585:THITH RS11360
gene id: 713585:THITH_RS11360
uniprot id: W0DP85
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

713585:THITH RS07540
gene id: 713585:THITH_RS07540
uniprot id: W0DMI1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

713585:THITH RS11405
gene id: 713585:THITH_RS11405
uniprot id: W0DPM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

713585:THITH RS06060
gene id: 713585:THITH_RS06060
uniprot id: W0DM15
names: Similarity
messages: Belongs to the bacterial glucokinase family.

713585:THITH RS04365
gene id: 713585:THITH_RS04365
uniprot id: W0DL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS16010
gene id: 713585:THITH_RS16010
uniprot id: W0DQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

713585:THITH RS08385
gene id: 713585:THITH_RS08385
uniprot id: W0DM42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS07715
gene id: 713585:THITH_RS07715
uniprot id: W0DHX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

713585:THITH RS13705
gene id: 713585:THITH_RS13705
uniprot id: W0DPR3
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS02825
gene id: 713585:THITH_RS02825
uniprot id: W0DK81
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

713585:THITH RS12035
gene id: 713585:THITH_RS12035
uniprot id: W0DPK0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS01120
gene id: 713585:THITH_RS01120
uniprot id: W0DJP1
names: Function
names: Subunit
messages: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
messages: Homodimer.

713585:THITH RS04640
gene id: 713585:THITH_RS04640
uniprot id: W0DLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

713585:THITH RS05815
gene id: 713585:THITH_RS05815
uniprot id: W0DKX0
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

713585:THITH RS04275
gene id: 713585:THITH_RS04275
uniprot id: W0DG54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

713585:THITH RS07730
gene id: 713585:THITH_RS07730
uniprot id: W0DLV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

713585:THITH RS14945
gene id: 713585:THITH_RS14945
uniprot id: W0DRE9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS11945
gene id: 713585:THITH_RS11945
uniprot id: W0DNT8
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

713585:THITH RS06395
gene id: 713585:THITH_RS06395
uniprot id: W0DH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

713585:THITH RS02530
gene id: 713585:THITH_RS02530
uniprot id: W0DG64
names: Subcellular Location Annotation
messages: Cytoplasm

713585:THITH RS15215
gene id: 713585:THITH_RS15215
uniprot id: W0DRJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

713585:THITH RS11835
gene id: 713585:THITH_RS11835
uniprot id: W0DKB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

713585:THITH RS06840
gene id: 713585:THITH_RS06840
uniprot id: W0DM39
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS07685
gene id: 713585:THITH_RS07685
uniprot id: W0DMK0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS01940
gene id: 713585:THITH_RS01940
uniprot id: W0DK33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

713585:THITH RS00400
gene id: 713585:THITH_RS00400
uniprot id: W0DJ07
names: Similarity
messages: Belongs to the phosphohexose mutase family.

713585:THITH RS03170
gene id: 713585:THITH_RS03170
uniprot id: W0DRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

713585:THITH RS06680
gene id: 713585:THITH_RS06680
uniprot id: W0DMA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

713585:THITH RS04950
gene id: 713585:THITH_RS04950
uniprot id: W0DLK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

713585:THITH RS09865
gene id: 713585:THITH_RS09865
uniprot id: W0DNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS08580
gene id: 713585:THITH_RS08580
uniprot id: W0DIA5
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

713585:THITH RS13420
gene id: 713585:THITH_RS13420
uniprot id: W0DQQ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

713585:THITH RS02475
gene id: 713585:THITH_RS02475
uniprot id: W0DKC1
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

713585:THITH RS07550
gene id: 713585:THITH_RS07550
uniprot id: W0DMT7
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

713585:THITH RS01225
gene id: 713585:THITH_RS01225
uniprot id: W0DJF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

713585:THITH RS16040
gene id: 713585:THITH_RS16040
uniprot id: W0DRM5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

713585:THITH RS01790
gene id: 713585:THITH_RS01790
uniprot id: W0DF25
names: Similarity
messages: Belongs to the heat shock protein 90 family.

713585:THITH RS02835
gene id: 713585:THITH_RS02835
uniprot id: W0DKJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

713585:THITH RS10120
gene id: 713585:THITH_RS10120
uniprot id: W0DTL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

713585:THITH RS14925
gene id: 713585:THITH_RS14925
uniprot id: W0DLU5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15110
gene id: 713585:THITH_RS15110
uniprot id: W0DLJ0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

713585:THITH RS10450
gene id: 713585:THITH_RS10450
uniprot id: W0DN38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

713585:THITH RS00535
gene id: 713585:THITH_RS00535
uniprot id: W0DJE8
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS10325
gene id: 713585:THITH_RS10325
uniprot id: W0DP25
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

713585:THITH RS14280
gene id: 713585:THITH_RS14280
uniprot id: W0DL56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

713585:THITH RS00525
gene id: 713585:THITH_RS00525
uniprot id: W0DJ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS00485
gene id: 713585:THITH_RS00485
uniprot id: W0DJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS00585
gene id: 713585:THITH_RS00585
uniprot id: W0DJG0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

713585:THITH RS04405
gene id: 713585:THITH_RS04405
uniprot id: W0DKY3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS13200
gene id: 713585:THITH_RS13200
uniprot id: W0DPE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

713585:THITH RS12390
gene id: 713585:THITH_RS12390
uniprot id: W0DK54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

713585:THITH RS01175
gene id: 713585:THITH_RS01175
uniprot id: W0DJE0
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS02180
gene id: 713585:THITH_RS02180
uniprot id: W0DG03
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS02710
gene id: 713585:THITH_RS02710
uniprot id: W0DKG6
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS09025
gene id: 713585:THITH_RS09025
uniprot id: W0DJ05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

713585:THITH RS00450
gene id: 713585:THITH_RS00450
uniprot id: W0DIB2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

713585:THITH RS00230
gene id: 713585:THITH_RS00230
uniprot id: W0DF19
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS11250
gene id: 713585:THITH_RS11250
uniprot id: W0DK11
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

713585:THITH RS16865
gene id: 713585:THITH_RS16865
uniprot id: W0DMV1
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

713585:THITH RS14015
gene id: 713585:THITH_RS14015
uniprot id: W0DQZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

713585:THITH RS01285
gene id: 713585:THITH_RS01285
uniprot id: W0DJG3
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

713585:THITH RS12595
gene id: 713585:THITH_RS12595
uniprot id: W0DK96
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

713585:THITH RS00605
gene id: 713585:THITH_RS00605
uniprot id: W0DEG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS13160
gene id: 713585:THITH_RS13160
uniprot id: W0DQG9
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15165
gene id: 713585:THITH_RS15165
uniprot id: W0DRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

713585:THITH RS11935
gene id: 713585:THITH_RS11935
uniprot id: W0DPX0
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

713585:THITH RS08230
gene id: 713585:THITH_RS08230
uniprot id: W0DMS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

713585:THITH RS11930
gene id: 713585:THITH_RS11930
uniprot id: W0DJX3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

713585:THITH RS11270
gene id: 713585:THITH_RS11270
uniprot id: W0DPK6
names: Similarity
messages: Belongs to the pyruvate kinase family.

713585:THITH RS05125
gene id: 713585:THITH_RS05125
uniprot id: W0DKM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

713585:THITH RS10185
gene id: 713585:THITH_RS10185
uniprot id: W0DP00
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS03645
gene id: 713585:THITH_RS03645
uniprot id: W0DJV2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS09290
gene id: 713585:THITH_RS09290
uniprot id: W0DJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

713585:THITH RS16270
gene id: 713585:THITH_RS16270
uniprot id: W0DRT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

713585:THITH RS13290
gene id: 713585:THITH_RS13290
uniprot id: W0DKN2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15205
gene id: 713585:THITH_RS15205
uniprot id: W0DR59
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03975
gene id: 713585:THITH_RS03975
uniprot id: W0DL08
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

713585:THITH RS00940
gene id: 713585:THITH_RS00940
uniprot id: W0DJA1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

713585:THITH RS15475
gene id: 713585:THITH_RS15475
uniprot id: W0DRP5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

713585:THITH RS07785
gene id: 713585:THITH_RS07785
uniprot id: W0DML7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

713585:THITH RS13730
gene id: 713585:THITH_RS13730
uniprot id: W0DPR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

713585:THITH RS13235
gene id: 713585:THITH_RS13235
uniprot id: W0DKL9
names: Similarity
messages: Belongs to the UPF0260 family.

713585:THITH RS09230
gene id: 713585:THITH_RS09230
uniprot id: W0DJ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS06900
gene id: 713585:THITH_RS06900
uniprot id: W0DLC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

713585:THITH RS14055
gene id: 713585:THITH_RS14055
uniprot id: W0DQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

713585:THITH RS12385
gene id: 713585:THITH_RS12385
uniprot id: W0DPQ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

713585:THITH RS14275
gene id: 713585:THITH_RS14275
uniprot id: W0DQQ6
names: Similarity
messages: Belongs to the MlaA family.

713585:THITH RS12705
gene id: 713585:THITH_RS12705
uniprot id: W0DP59
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

713585:THITH RS01755
gene id: 713585:THITH_RS01755
uniprot id: W0DJR0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

713585:THITH RS12565
gene id: 713585:THITH_RS12565
uniprot id: W0DK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS03425
gene id: 713585:THITH_RS03425
uniprot id: W0DKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

713585:THITH RS04190
gene id: 713585:THITH_RS04190
uniprot id: W0DK47
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.

713585:THITH RS02605
gene id: 713585:THITH_RS02605
uniprot id: W0DG78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

713585:THITH RS11450
gene id: 713585:THITH_RS11450
uniprot id: W0DP98
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

713585:THITH RS13490
gene id: 713585:THITH_RS13490
uniprot id: W0DPM9
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

713585:THITH RS08745
gene id: 713585:THITH_RS08745
uniprot id: W0DID2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS14060
gene id: 713585:THITH_RS14060
uniprot id: W0DL26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

713585:THITH RS00430
gene id: 713585:THITH_RS00430
uniprot id: W0DJ12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

713585:THITH RS15410
gene id: 713585:THITH_RS15410
uniprot id: W0DQH8
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

713585:THITH RS10695
gene id: 713585:THITH_RS10695
uniprot id: W0DPC5
names: Similarity
messages: Belongs to the YoeB family.

713585:THITH RS16765
gene id: 713585:THITH_RS16765
uniprot id: W0DMT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

713585:THITH RS10545
gene id: 713585:THITH_RS10545
uniprot id: W0DPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS12480
gene id: 713585:THITH_RS12480
uniprot id: W0DPS4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

713585:THITH RS12860
gene id: 713585:THITH_RS12860
uniprot id: W0DQB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

713585:THITH RS13810
gene id: 713585:THITH_RS13810
uniprot id: W0DKY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

713585:THITH RS12735
gene id: 713585:THITH_RS12735
uniprot id: W0DPX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS10455
gene id: 713585:THITH_RS10455
uniprot id: W0DNU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

713585:THITH RS00895
gene id: 713585:THITH_RS00895
uniprot id: W0DEK1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

713585:THITH RS10035
gene id: 713585:THITH_RS10035
uniprot id: W0DNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS14225
gene id: 713585:THITH_RS14225
uniprot id: W0DL50
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

713585:THITH RS02655
gene id: 713585:THITH_RS02655
uniprot id: W0DG86
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS13725
gene id: 713585:THITH_RS13725
uniprot id: W0DLA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

713585:THITH RS00125
gene id: 713585:THITH_RS00125
uniprot id: W0DJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS13755
gene id: 713585:THITH_RS13755
uniprot id: W0DQH3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

713585:THITH RS15945
gene id: 713585:THITH_RS15945
uniprot id: W0DM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

713585:THITH RS02690
gene id: 713585:THITH_RS02690
uniprot id: W0DJF9
names: Similarity
messages: Belongs to the peptidase U62 family.

713585:THITH RS05290
gene id: 713585:THITH_RS05290
uniprot id: W0DLD2
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

713585:THITH RS01920
gene id: 713585:THITH_RS01920
uniprot id: W0DFW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

713585:THITH RS02795
gene id: 713585:THITH_RS02795
uniprot id: W0DJI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS02680
gene id: 713585:THITH_RS02680
uniprot id: W0DKG0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

713585:THITH RS09790
gene id: 713585:THITH_RS09790
uniprot id: W0DNH5
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS00020
gene id: 713585:THITH_RS00020
uniprot id: W0DIU1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

713585:THITH RS15435
gene id: 713585:THITH_RS15435
uniprot id: W0DQI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

713585:THITH RS14515
gene id: 713585:THITH_RS14515
uniprot id: W0DLP2
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

713585:THITH RS14555
gene id: 713585:THITH_RS14555
uniprot id: W0DLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

713585:THITH RS14480
gene id: 713585:THITH_RS14480
uniprot id: W0DL91
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

713585:THITH RS16975
gene id: 713585:THITH_RS16975
uniprot id: W0DRC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

713585:THITH RS00170
gene id: 713585:THITH_RS00170
uniprot id: W0DI61
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

713585:THITH RS15835
gene id: 713585:THITH_RS15835
uniprot id: W0DLX6
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

713585:THITH RS13685
gene id: 713585:THITH_RS13685
uniprot id: W0DQF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

713585:THITH RS06195
gene id: 713585:THITH_RS06195
uniprot id: W0DHQ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS02725
gene id: 713585:THITH_RS02725
uniprot id: W0DK64
names: Similarity
messages: Belongs to the WrbA family.

713585:THITH RS10255
gene id: 713585:THITH_RS10255
uniprot id: W0DNP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS02540
gene id: 713585:THITH_RS02540
uniprot id: W0DK34
names: Similarity
messages: Belongs to the PhoH family.

713585:THITH RS09550
gene id: 713585:THITH_RS09550
uniprot id: W0DNE2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

713585:THITH RS08100
gene id: 713585:THITH_RS08100
uniprot id: W0DN19
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS10000
gene id: 713585:THITH_RS10000
uniprot id: W0DNK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS00025
gene id: 713585:THITH_RS00025
uniprot id: W0DE64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

713585:THITH RS11455
gene id: 713585:THITH_RS11455
uniprot id: W0DJN9
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

713585:THITH RS07430
gene id: 713585:THITH_RS07430
uniprot id: W0DMG5
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

713585:THITH RS00110
gene id: 713585:THITH_RS00110
uniprot id: W0DI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS04510
gene id: 713585:THITH_RS04510
uniprot id: W0DGC3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS00855
gene id: 713585:THITH_RS00855
uniprot id: W0DIH3
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

713585:THITH RS13505
gene id: 713585:THITH_RS13505
uniprot id: W0DQR5
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS10055
gene id: 713585:THITH_RS10055
uniprot id: W0DJ02
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

713585:THITH RS06400
gene id: 713585:THITH_RS06400
uniprot id: W0DM70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

713585:THITH RS07210
gene id: 713585:THITH_RS07210
uniprot id: W0DHM0
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS01415
gene id: 713585:THITH_RS01415
uniprot id: W0DEX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

713585:THITH RS15480
gene id: 713585:THITH_RS15480
uniprot id: W0DM48
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

713585:THITH RS02390
gene id: 713585:THITH_RS02390
uniprot id: W0DK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

713585:THITH RS02980
gene id: 713585:THITH_RS02980
uniprot id: W0DFK3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

713585:THITH RS10550
gene id: 713585:THITH_RS10550
uniprot id: W0DJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS03485
gene id: 713585:THITH_RS03485
uniprot id: W0DKT0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

713585:THITH RS01250
gene id: 713585:THITH_RS01250
uniprot id: W0DRF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

713585:THITH RS07860
gene id: 713585:THITH_RS07860
uniprot id: W0DMY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

713585:THITH RS05920
gene id: 713585:THITH_RS05920
uniprot id: W0DLY9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS13260
gene id: 713585:THITH_RS13260
uniprot id: W0DKM6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS12835
gene id: 713585:THITH_RS12835
uniprot id: W0DKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

713585:THITH RS16630
gene id: 713585:THITH_RS16630
uniprot id: W0DR73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

713585:THITH RS15270
gene id: 713585:THITH_RS15270
uniprot id: W0DQE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

713585:THITH RS03250
gene id: 713585:THITH_RS03250
uniprot id: W0DKP5
names: Similarity
messages: Belongs to the UPF0225 family.

713585:THITH RS01240
gene id: 713585:THITH_RS01240
uniprot id: W0DJR5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

713585:THITH RS11905
gene id: 713585:THITH_RS11905
uniprot id: W0DJW8
names: Similarity
messages: Belongs to the SufE family.

713585:THITH RS13740
gene id: 713585:THITH_RS13740
uniprot id: W0DQV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

713585:THITH RS16495
gene id: 713585:THITH_RS16495
uniprot id: W0DR52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

713585:THITH RS09065
gene id: 713585:THITH_RS09065
uniprot id: W0DME9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

713585:THITH RS05030
gene id: 713585:THITH_RS05030
uniprot id: W0DL93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

713585:THITH RS14415
gene id: 713585:THITH_RS14415
uniprot id: W0DQ26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS02415
gene id: 713585:THITH_RS02415
uniprot id: W0DK15
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

713585:THITH RS04305
gene id: 713585:THITH_RS04305
uniprot id: W0DG59
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS11040
gene id: 713585:THITH_RS11040
uniprot id: W0DP41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

713585:THITH RS13610
gene id: 713585:THITH_RS13610
uniprot id: W0DTR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

713585:THITH RS02845
gene id: 713585:THITH_RS02845
uniprot id: W0DJI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

713585:THITH RS14950
gene id: 713585:THITH_RS14950
uniprot id: W0DLV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

713585:THITH RS15450
gene id: 713585:THITH_RS15450
uniprot id: W0DRN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS13655
gene id: 713585:THITH_RS13655
uniprot id: W0DPQ5
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS11975
gene id: 713585:THITH_RS11975
uniprot id: W0DPJ1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO small chain family.
messages: Heterohexadecamer of 8 large and 8 small subunits.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

713585:THITH RS03700
gene id: 713585:THITH_RS03700
uniprot id: W0DGM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

713585:THITH RS03760
gene id: 713585:THITH_RS03760
uniprot id: W0DJX1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

713585:THITH RS06005
gene id: 713585:THITH_RS06005
uniprot id: W0DM03
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS02815
gene id: 713585:THITH_RS02815
uniprot id: W0DGB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

713585:THITH RS07170
gene id: 713585:THITH_RS07170
uniprot id: W0DLH8
names: Similarity
messages: Belongs to the MEMO1 family.

713585:THITH RS15815
gene id: 713585:THITH_RS15815
uniprot id: W0DMA8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

713585:THITH RS04770
gene id: 713585:THITH_RS04770
uniprot id: W0DLH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

713585:THITH RS14100
gene id: 713585:THITH_RS14100
uniprot id: W0DLH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

713585:THITH RS14195
gene id: 713585:THITH_RS14195
uniprot id: W0DQP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

713585:THITH RS07720
gene id: 713585:THITH_RS07720
uniprot id: W0DMW4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.

713585:THITH RS09730
gene id: 713585:THITH_RS09730
uniprot id: W0DNT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

713585:THITH RS11515
gene id: 713585:THITH_RS11515
uniprot id: W0DPP4
names: Similarity
messages: Belongs to the YfgM family.

713585:THITH RS08885
gene id: 713585:THITH_RS08885
uniprot id: W0DIF2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

713585:THITH RS12755
gene id: 713585:THITH_RS12755
uniprot id: W0DP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

713585:THITH RS15500
gene id: 713585:THITH_RS15500
uniprot id: W0DRP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

713585:THITH RS14315
gene id: 713585:THITH_RS14315
uniprot id: W0DLL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

713585:THITH RS15460
gene id: 713585:THITH_RS15460
uniprot id: W0DQI9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

713585:THITH RS10115
gene id: 713585:THITH_RS10115
uniprot id: W0DJH8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS10400
gene id: 713585:THITH_RS10400
uniprot id: W0DNR8
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

713585:THITH RS14110
gene id: 713585:THITH_RS14110
uniprot id: W0DQN0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

713585:THITH RS11480
gene id: 713585:THITH_RS11480
uniprot id: W0DPA3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

713585:THITH RS02395
gene id: 713585:THITH_RS02395
uniprot id: W0DFB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

713585:THITH RS07585
gene id: 713585:THITH_RS07585
uniprot id: W0DMU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

713585:THITH RS04285
gene id: 713585:THITH_RS04285
uniprot id: W0DL64
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS14050
gene id: 713585:THITH_RS14050
uniprot id: W0DPX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

713585:THITH RS04760
gene id: 713585:THITH_RS04760
uniprot id: W0DL47
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

713585:THITH RS04860
gene id: 713585:THITH_RS04860
uniprot id: W0DKI7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

713585:THITH RS15935
gene id: 713585:THITH_RS15935
uniprot id: W0DTI7
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS01665
gene id: 713585:THITH_RS01665
uniprot id: W0DJP5
names: Similarity
messages: Belongs to the peptidase S16 family.

713585:THITH RS11780
gene id: 713585:THITH_RS11780
uniprot id: W0DP30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

713585:THITH RS11830
gene id: 713585:THITH_RS11830
uniprot id: W0DPV0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

713585:THITH RS13545
gene id: 713585:THITH_RS13545
uniprot id: W0DPN8
names: Similarity
messages: Belongs to the P(II) protein family.

713585:THITH RS06670
gene id: 713585:THITH_RS06670
uniprot id: W0DQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

713585:THITH RS10735
gene id: 713585:THITH_RS10735
uniprot id: W0DPD0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS16705
gene id: 713585:THITH_RS16705
uniprot id: W0DSC4
names: Similarity
messages: Belongs to the asparagine synthetase family.

713585:THITH RS05080
gene id: 713585:THITH_RS05080
uniprot id: W0DLL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS05390
gene id: 713585:THITH_RS05390
uniprot id: W0DGR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TraY family.
messages: Cytoplasm

713585:THITH RS00070
gene id: 713585:THITH_RS00070
uniprot id: W0DIU9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

713585:THITH RS04730
gene id: 713585:THITH_RS04730
uniprot id: W0DNC0
names: Similarity
messages: Belongs to the PrpD family.

713585:THITH RS12800
gene id: 713585:THITH_RS12800
uniprot id: W0DQA6
names: Similarity
messages: Belongs to the UPF0047 family.

713585:THITH RS09785
gene id: 713585:THITH_RS09785
uniprot id: W0DMQ1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

713585:THITH RS16785
gene id: 713585:THITH_RS16785
uniprot id: W0DSD5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

713585:THITH RS12815
gene id: 713585:THITH_RS12815
uniprot id: W0DP79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

713585:THITH RS16500
gene id: 713585:THITH_RS16500
uniprot id: W0DRW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

713585:THITH RS07030
gene id: 713585:THITH_RS07030
uniprot id: W0DLF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

713585:THITH RS01420
gene id: 713585:THITH_RS01420
uniprot id: W0DJX2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

713585:THITH RS02005
gene id: 713585:THITH_RS02005
uniprot id: W0DFX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS14290
gene id: 713585:THITH_RS14290
uniprot id: W0DLK9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

713585:THITH RS15625
gene id: 713585:THITH_RS15625
uniprot id: W0DLT4
names: Similarity
messages: Belongs to the peptidase C59 family.

713585:THITH RS00050
gene id: 713585:THITH_RS00050
uniprot id: W0DE69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

713585:THITH RS08280
gene id: 713585:THITH_RS08280
uniprot id: W0DIP4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS13845
gene id: 713585:THITH_RS13845
uniprot id: W0DLC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

713585:THITH RS02820
gene id: 713585:THITH_RS02820
uniprot id: W0DJI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

713585:THITH RS07610
gene id: 713585:THITH_RS07610
uniprot id: W0DHW3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

713585:THITH RS00595
gene id: 713585:THITH_RS00595
uniprot id: W0DID7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

713585:THITH RS06065
gene id: 713585:THITH_RS06065
uniprot id: W0DHN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

713585:THITH RS11810
gene id: 713585:THITH_RS11810
uniprot id: W0DNR4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

713585:THITH RS00010
gene id: 713585:THITH_RS00010
uniprot id: W0DI39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

713585:THITH RS12935
gene id: 713585:THITH_RS12935
uniprot id: W0DQ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

713585:THITH RS03795
gene id: 713585:THITH_RS03795
uniprot id: W0DJX7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03720
gene id: 713585:THITH_RS03720
uniprot id: W0DFW3
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06810
gene id: 713585:THITH_RS06810
uniprot id: W0DLA8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

713585:THITH RS02360
gene id: 713585:THITH_RS02360
uniprot id: W0DJA3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

713585:THITH RS15700
gene id: 713585:THITH_RS15700
uniprot id: W0DL85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

713585:THITH RS06015
gene id: 713585:THITH_RS06015
uniprot id: W0DKZ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

713585:THITH RS11550
gene id: 713585:THITH_RS11550
uniprot id: W0DK66
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

713585:THITH RS10535
gene id: 713585:THITH_RS10535
uniprot id: W0DNW8
names: Similarity
messages: Belongs to the pirin family.

713585:THITH RS04625
gene id: 713585:THITH_RS04625
uniprot id: W0DKF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

713585:THITH RS11000
gene id: 713585:THITH_RS11000
uniprot id: W0DPH1
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

713585:THITH RS14010
gene id: 713585:THITH_RS14010
uniprot id: W0DL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

713585:THITH RS13590
gene id: 713585:THITH_RS13590
uniprot id: W0DL87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

713585:THITH RS04245
gene id: 713585:THITH_RS04245
uniprot id: W0DKT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

713585:THITH RS12205
gene id: 713585:THITH_RS12205
uniprot id: W0DPM4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

713585:THITH RS02555
gene id: 713585:THITH_RS02555
uniprot id: W0DG69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

713585:THITH RS14295
gene id: 713585:THITH_RS14295
uniprot id: W0DQ06
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

713585:THITH RS05355
gene id: 713585:THITH_RS05355
uniprot id: W0DNE7
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS06120
gene id: 713585:THITH_RS06120
uniprot id: W0DL10
names: Similarity
messages: Belongs to the UPF0250 family.

713585:THITH RS10065
gene id: 713585:THITH_RS10065
uniprot id: W0DJG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

713585:THITH RS12685
gene id: 713585:THITH_RS12685
uniprot id: W0DQ89
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

713585:THITH RS08520
gene id: 713585:THITH_RS08520
uniprot id: W0DI95
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

713585:THITH RS07240
gene id: 713585:THITH_RS07240
uniprot id: W0DMK7
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

713585:THITH RS02805
gene id: 713585:THITH_RS02805
uniprot id: W0DFI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

713585:THITH RS16425
gene id: 713585:THITH_RS16425
uniprot id: W0DRV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

713585:THITH RS11725
gene id: 713585:THITH_RS11725
uniprot id: W0DK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

713585:THITH RS15180
gene id: 713585:THITH_RS15180
uniprot id: W0DR56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

713585:THITH RS13090
gene id: 713585:THITH_RS13090
uniprot id: W0DKX1
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS12585
gene id: 713585:THITH_RS12585
uniprot id: W0DP37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

713585:THITH RS09885
gene id: 713585:THITH_RS09885
uniprot id: W0DIX1
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

713585:THITH RS12740
gene id: 713585:THITH_RS12740
uniprot id: W0DKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

713585:THITH RS15045
gene id: 713585:THITH_RS15045
uniprot id: W0DQB8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

713585:THITH RS15705
gene id: 713585:THITH_RS15705
uniprot id: W0DQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

713585:THITH RS06085
gene id: 713585:THITH_RS06085
uniprot id: W0DM19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

713585:THITH RS14920
gene id: 713585:THITH_RS14920
uniprot id: W0DRE3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

713585:THITH RS10460
gene id: 713585:THITH_RS10460
uniprot id: W0DJ86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

713585:THITH RS03460
gene id: 713585:THITH_RS03460
uniprot id: W0DKS5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

713585:THITH RS16905
gene id: 713585:THITH_RS16905
uniprot id: W0DS28
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

713585:THITH RS12430
gene id: 713585:THITH_RS12430
uniprot id: W0DPR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

713585:THITH RS16525
gene id: 713585:THITH_RS16525
uniprot id: W0DRX1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS15155
gene id: 713585:THITH_RS15155
uniprot id: W0DR51
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS07335
gene id: 713585:THITH_RS07335
uniprot id: W0DIB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

713585:THITH RS05060
gene id: 713585:THITH_RS05060
uniprot id: W0DH83
names: Similarity
messages: Belongs to the UPF0166 family.

713585:THITH RS08940
gene id: 713585:THITH_RS08940
uniprot id: W0DN47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

713585:THITH RS05190
gene id: 713585:THITH_RS05190
uniprot id: W0DLN2
names: Similarity
messages: Belongs to the CmpA/NrtA family.

713585:THITH RS05150
gene id: 713585:THITH_RS05150
uniprot id: W0DKM7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

713585:THITH RS09090
gene id: 713585:THITH_RS09090
uniprot id: W0DJ16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

713585:THITH RS12445
gene id: 713585:THITH_RS12445
uniprot id: W0DKK9
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS11075
gene id: 713585:THITH_RS11075
uniprot id: W0DPI4
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

713585:THITH RS16255
gene id: 713585:THITH_RS16255
uniprot id: W0DS59
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

713585:THITH RS14160
gene id: 713585:THITH_RS14160
uniprot id: W0DQN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

713585:THITH RS15735
gene id: 713585:THITH_RS15735
uniprot id: W0DM90
names: Similarity
messages: Belongs to the cytochrome c-552 family.

713585:THITH RS10110
gene id: 713585:THITH_RS10110
uniprot id: W0DNY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

713585:THITH RS06995
gene id: 713585:THITH_RS06995
uniprot id: W0DMG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

713585:THITH RS05875
gene id: 713585:THITH_RS05875
uniprot id: W0DHJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

713585:THITH RS09150
gene id: 713585:THITH_RS09150
uniprot id: W0DN82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

713585:THITH RS12560
gene id: 713585:THITH_RS12560
uniprot id: W0DPU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS14835
gene id: 713585:THITH_RS14835
uniprot id: W0DNW4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS13870
gene id: 713585:THITH_RS13870
uniprot id: W0DLD4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

713585:THITH RS07690
gene id: 713585:THITH_RS07690
uniprot id: W0DHX1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

713585:THITH RS15580
gene id: 713585:THITH_RS15580
uniprot id: W0DRR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

713585:THITH RS06325
gene id: 713585:THITH_RS06325
uniprot id: W0DHS4
names: Similarity
messages: Belongs to the YkuD family.

713585:THITH RS15690
gene id: 713585:THITH_RS15690
uniprot id: W0DLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

713585:THITH RS07460
gene id: 713585:THITH_RS07460
uniprot id: W0DHU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

713585:THITH RS15305
gene id: 713585:THITH_RS15305
uniprot id: W0DR78
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

713585:THITH RS00015
gene id: 713585:THITH_RS00015
uniprot id: W0DSG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

713585:THITH RS15865
gene id: 713585:THITH_RS15865
uniprot id: W0DRV8
names: Similarity
messages: Belongs to the GARS family.

713585:THITH RS11555
gene id: 713585:THITH_RS11555
uniprot id: W0DNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS01825
gene id: 713585:THITH_RS01825
uniprot id: W0DF28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

713585:THITH RS06655
gene id: 713585:THITH_RS06655
uniprot id: W0DMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

713585:THITH RS11025
gene id: 713585:THITH_RS11025
uniprot id: W0DPH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

713585:THITH RS12570
gene id: 713585:THITH_RS12570
uniprot id: W0DQ69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS12525
gene id: 713585:THITH_RS12525
uniprot id: W0DKM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS02355
gene id: 713585:THITH_RS02355
uniprot id: W0DG34
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

713585:THITH RS06740
gene id: 713585:THITH_RS06740
uniprot id: W0DMC0
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

713585:THITH RS08470
gene id: 713585:THITH_RS08470
uniprot id: W0DI86
names: Similarity
messages: Belongs to the ClpA/ClpB family.

713585:THITH RS15955
gene id: 713585:THITH_RS15955
uniprot id: W0DMD5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

713585:THITH RS09615
gene id: 713585:THITH_RS09615
uniprot id: W0DNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Periplasm

713585:THITH RS07725
gene id: 713585:THITH_RS07725
uniprot id: W0DII1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

713585:THITH RS04785
gene id: 713585:THITH_RS04785
uniprot id: W0DL54
names: Similarity
messages: Belongs to the peptidase S11 family.

713585:THITH RS12925
gene id: 713585:THITH_RS12925
uniprot id: W0DSL1
names: Similarity
messages: Belongs to the CopC family.

713585:THITH RS09330
gene id: 713585:THITH_RS09330
uniprot id: W0DIP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

713585:THITH RS13475
gene id: 713585:THITH_RS13475
uniprot id: W0DQR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

713585:THITH RS06170
gene id: 713585:THITH_RS06170
uniprot id: W0DHQ3
names: Similarity
messages: Belongs to the CFA/CMAS family.

713585:THITH RS10620
gene id: 713585:THITH_RS10620
uniprot id: W0DN81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

713585:THITH RS00550
gene id: 713585:THITH_RS00550
uniprot id: W0DJ39
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15920
gene id: 713585:THITH_RS15920
uniprot id: W0DRX0
names: Similarity
messages: Belongs to the fructosamine kinase family.

713585:THITH RS12650
gene id: 713585:THITH_RS12650
uniprot id: W0DQ83
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

713585:THITH RS16915
gene id: 713585:THITH_RS16915
uniprot id: W0DSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

713585:THITH RS00905
gene id: 713585:THITH_RS00905
uniprot id: W0DFD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03990
gene id: 713585:THITH_RS03990
uniprot id: W0DKQ1
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS09880
gene id: 713585:THITH_RS09880
uniprot id: W0DNI5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

713585:THITH RS06140
gene id: 713585:THITH_RS06140
uniprot id: W0DHP8
names: Similarity
messages: Belongs to the BolA/IbaG family.

713585:THITH RS13180
gene id: 713585:THITH_RS13180
uniprot id: W0DQ51
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

713585:THITH RS01435
gene id: 713585:THITH_RS01435
uniprot id: W0DJM1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

713585:THITH RS08450
gene id: 713585:THITH_RS08450
uniprot id: W0DN68
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

713585:THITH RS07025
gene id: 713585:THITH_RS07025
uniprot id: W0DI52
names: Similarity
messages: Belongs to the ArsC family.

713585:THITH RS10050
gene id: 713585:THITH_RS10050
uniprot id: W0DNL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

713585:THITH RS07675
gene id: 713585:THITH_RS07675
uniprot id: W0DIH5
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

713585:THITH RS16110
gene id: 713585:THITH_RS16110
uniprot id: W0DS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

713585:THITH RS12750
gene id: 713585:THITH_RS12750
uniprot id: W0DKR2
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

713585:THITH RS09120
gene id: 713585:THITH_RS09120
uniprot id: W0DMF7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

713585:THITH RS02265
gene id: 713585:THITH_RS02265
uniprot id: W0DF91
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

713585:THITH RS00285
gene id: 713585:THITH_RS00285
uniprot id: W0DI79
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS11245
gene id: 713585:THITH_RS11245
uniprot id: W0DPK2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

713585:THITH RS08350
gene id: 713585:THITH_RS08350
uniprot id: W0DIQ0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS05035
gene id: 713585:THITH_RS05035
uniprot id: W0DGK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

713585:THITH RS14175
gene id: 713585:THITH_RS14175
uniprot id: W0DR25
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS03440
gene id: 713585:THITH_RS03440
uniprot id: W0DGJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

713585:THITH RS14955
gene id: 713585:THITH_RS14955
uniprot id: W0DQA4
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

713585:THITH RS05880
gene id: 713585:THITH_RS05880
uniprot id: W0DKX8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

713585:THITH RS10755
gene id: 713585:THITH_RS10755
uniprot id: W0DJE5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS06075
gene id: 713585:THITH_RS06075
uniprot id: W0DLQ3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

713585:THITH RS15135
gene id: 713585:THITH_RS15135
uniprot id: W0DLJ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

713585:THITH RS07265
gene id: 713585:THITH_RS07265
uniprot id: W0DMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Periplasm

713585:THITH RS13900
gene id: 713585:THITH_RS13900
uniprot id: W0DPU9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

713585:THITH RS12380
gene id: 713585:THITH_RS12380
uniprot id: W0DNZ1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

713585:THITH RS01185
gene id: 713585:THITH_RS01185
uniprot id: W0DJQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS01585
gene id: 713585:THITH_RS01585
uniprot id: W0DIZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

713585:THITH RS12930
gene id: 713585:THITH_RS12930
uniprot id: W0DTE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance. Appears to be involved in copper uptake.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

713585:THITH RS14125
gene id: 713585:THITH_RS14125
uniprot id: W0DLI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

713585:THITH RS15385
gene id: 713585:THITH_RS15385
uniprot id: W0DR95
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS10420
gene id: 713585:THITH_RS10420
uniprot id: W0DN18
names: Similarity
messages: Belongs to the TrpF family.

713585:THITH RS09895
gene id: 713585:THITH_RS09895
uniprot id: W0DJD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

713585:THITH RS10950
gene id: 713585:THITH_RS10950
uniprot id: W0DJW4
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS07910
gene id: 713585:THITH_RS07910
uniprot id: W0DLY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

713585:THITH RS14740
gene id: 713585:THITH_RS14740
uniprot id: W0DLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS13005
gene id: 713585:THITH_RS13005
uniprot id: W0DQD5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

713585:THITH RS08150
gene id: 713585:THITH_RS08150
uniprot id: W0DI38
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Binds 2 calcium ions per subunit.
messages: Binds 6 Cu cations per subunit. Each subunit contains 2 copper centers; Cu(A) (binuclear) and Cu(Z) (tetranuclear). Cu(Z) is thought to be the site of nitrous oxide reduction.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

713585:THITH RS10015
gene id: 713585:THITH_RS10015
uniprot id: W0DJF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

713585:THITH RS11155
gene id: 713585:THITH_RS11155
uniprot id: W0DJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

713585:THITH RS13350
gene id: 713585:THITH_RS13350
uniprot id: W0DQN4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

713585:THITH RS11980
gene id: 713585:THITH_RS11980
uniprot id: W0DJY5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterohexadecamer of 8 large chains and 8 small chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

713585:THITH RS06250
gene id: 713585:THITH_RS06250
uniprot id: W0DM47
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

713585:THITH RS06805
gene id: 713585:THITH_RS06805
uniprot id: W0DI13
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

713585:THITH RS14535
gene id: 713585:THITH_RS14535
uniprot id: W0DR86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

713585:THITH RS15200
gene id: 713585:THITH_RS15200
uniprot id: W0DQE2
names: Similarity
messages: Belongs to the UPF0758 family.

713585:THITH RS13970
gene id: 713585:THITH_RS13970
uniprot id: W0DPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

713585:THITH RS08425
gene id: 713585:THITH_RS08425
uniprot id: W0DN63
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

713585:THITH RS06080
gene id: 713585:THITH_RS06080
uniprot id: W0DH15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

713585:THITH RS16880
gene id: 713585:THITH_RS16880
uniprot id: W0DS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

713585:THITH RS00925
gene id: 713585:THITH_RS00925
uniprot id: W0DJL3
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

713585:THITH RS02600
gene id: 713585:THITH_RS02600
uniprot id: W0DKE1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

713585:THITH RS16870
gene id: 713585:THITH_RS16870
uniprot id: W0DRA5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

713585:THITH RS09555
gene id: 713585:THITH_RS09555
uniprot id: W0DIS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS11345
gene id: 713585:THITH_RS11345
uniprot id: W0DPM1
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

713585:THITH RS11310
gene id: 713585:THITH_RS11310
uniprot id: W0DP77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

713585:THITH RS08505
gene id: 713585:THITH_RS08505
uniprot id: W0DIS6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

713585:THITH RS03455
gene id: 713585:THITH_RS03455
uniprot id: W0DFR3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

713585:THITH RS13595
gene id: 713585:THITH_RS13595
uniprot id: W0DPP7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

713585:THITH RS10190
gene id: 713585:THITH_RS10190
uniprot id: W0DJI6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

713585:THITH RS14470
gene id: 713585:THITH_RS14470
uniprot id: W0DQ36
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

713585:THITH RS00440
gene id: 713585:THITH_RS00440
uniprot id: W0DJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

713585:THITH RS10085
gene id: 713585:THITH_RS10085
uniprot id: W0DNY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

713585:THITH RS13175
gene id: 713585:THITH_RS13175
uniprot id: W0DPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

713585:THITH RS13735
gene id: 713585:THITH_RS13735
uniprot id: W0DQG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

713585:THITH RS15485
gene id: 713585:THITH_RS15485
uniprot id: W0DQJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS02175
gene id: 713585:THITH_RS02175
uniprot id: W0DK74
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS11240
gene id: 713585:THITH_RS11240
uniprot id: W0DJK5
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

713585:THITH RS11420
gene id: 713585:THITH_RS11420
uniprot id: W0DP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS10070
gene id: 713585:THITH_RS10070
uniprot id: W0DMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

713585:THITH RS09320
gene id: 713585:THITH_RS09320
uniprot id: W0DMI6
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

713585:THITH RS05215
gene id: 713585:THITH_RS05215
uniprot id: W0DLN6
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

713585:THITH RS13905
gene id: 713585:THITH_RS13905
uniprot id: W0DQK2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS04250
gene id: 713585:THITH_RS04250
uniprot id: W0DG49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

713585:THITH RS14865
gene id: 713585:THITH_RS14865
uniprot id: W0DQ92
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

713585:THITH RS10130
gene id: 713585:THITH_RS10130
uniprot id: W0DMW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

713585:THITH RS02865
gene id: 713585:THITH_RS02865
uniprot id: W0DGB8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

713585:THITH RS00700
gene id: 713585:THITH_RS00700
uniprot id: W0DEH7
names: Similarity
messages: Belongs to the peptidase S8 family.

713585:THITH RS04295
gene id: 713585:THITH_RS04295
uniprot id: W0DK70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS15585
gene id: 713585:THITH_RS15585
uniprot id: W0DM66
names: Similarity
messages: Belongs to the YggT family.

713585:THITH RS11855
gene id: 713585:THITH_RS11855
uniprot id: W0DPV5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

713585:THITH RS15630
gene id: 713585:THITH_RS15630
uniprot id: W0DNX5
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS01145
gene id: 713585:THITH_RS01145
uniprot id: W0DJD5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS15185
gene id: 713585:THITH_RS15185
uniprot id: W0DLK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

713585:THITH RS12630
gene id: 713585:THITH_RS12630
uniprot id: W0DKP4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

713585:THITH RS15210
gene id: 713585:THITH_RS15210
uniprot id: W0DLL2
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

713585:THITH RS14815
gene id: 713585:THITH_RS14815
uniprot id: W0DQZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

713585:THITH RS11660
gene id: 713585:THITH_RS11660
uniprot id: W0DPD6
names: Similarity
messages: Belongs to the HesB/IscA family.

713585:THITH RS13710
gene id: 713585:THITH_RS13710
uniprot id: W0DQG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

713585:THITH RS02665
gene id: 713585:THITH_RS02665
uniprot id: W0DK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

713585:THITH RS13135
gene id: 713585:THITH_RS13135
uniprot id: W0DQG3
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

713585:THITH RS05430
gene id: 713585:THITH_RS05430
uniprot id: W0DHD7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS07360
gene id: 713585:THITH_RS07360
uniprot id: W0DID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

713585:THITH RS09285
gene id: 713585:THITH_RS09285
uniprot id: W0DNL3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

713585:THITH RS10210
gene id: 713585:THITH_RS10210
uniprot id: W0DMX4
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

713585:THITH RS01320
gene id: 713585:THITH_RS01320
uniprot id: W0DJT4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS14840
gene id: 713585:THITH_RS14840
uniprot id: W0DQ88
names: Similarity
messages: Belongs to the CutA family.

713585:THITH RS07455
gene id: 713585:THITH_RS07455
uniprot id: W0DMH3
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

713585:THITH RS16815
gene id: 713585:THITH_RS16815
uniprot id: W0DMU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

713585:THITH RS15575
gene id: 713585:THITH_RS15575
uniprot id: W0DLS3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

713585:THITH RS16640
gene id: 713585:THITH_RS16640
uniprot id: W0DMD9
names: Similarity
messages: Belongs to the SCO1/2 family.

713585:THITH RS03520
gene id: 713585:THITH_RS03520
uniprot id: W0DGK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

713585:THITH RS05810
gene id: 713585:THITH_RS05810
uniprot id: W0DHI5
names: Similarity
messages: Belongs to the polysaccharide synthase family.

713585:THITH RS13965
gene id: 713585:THITH_RS13965
uniprot id: W0DLF0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

713585:THITH RS14285
gene id: 713585:THITH_RS14285
uniprot id: W0DR44
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

713585:THITH RS09050
gene id: 713585:THITH_RS09050
uniprot id: W0DII0
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

713585:THITH RS13915
gene id: 713585:THITH_RS13915
uniprot id: W0DL03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

713585:THITH RS03135
gene id: 713585:THITH_RS03135
uniprot id: W0DJM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

713585:THITH RS11135
gene id: 713585:THITH_RS11135
uniprot id: W0DPJ3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

713585:THITH RS02850
gene id: 713585:THITH_RS02850
uniprot id: W0DK84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

713585:THITH RS12590
gene id: 713585:THITH_RS12590
uniprot id: W0DPU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

713585:THITH RS13790
gene id: 713585:THITH_RS13790
uniprot id: W0DQW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

713585:THITH RS09805
gene id: 713585:THITH_RS09805
uniprot id: W0DT29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS01850
gene id: 713585:THITH_RS01850
uniprot id: W0DJS1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

713585:THITH RS16930
gene id: 713585:THITH_RS16930
uniprot id: W0DS31
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

713585:THITH RS06390
gene id: 713585:THITH_RS06390
uniprot id: W0DLW0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

713585:THITH RS13935
gene id: 713585:THITH_RS13935
uniprot id: W0DQY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

713585:THITH RS07435
gene id: 713585:THITH_RS07435
uniprot id: W0DHU1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

713585:THITH RS11425
gene id: 713585:THITH_RS11425
uniprot id: W0DJN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

713585:THITH RS09570
gene id: 713585:THITH_RS09570
uniprot id: W0DML9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS01970
gene id: 713585:THITH_RS01970
uniprot id: W0DF48
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS04620
gene id: 713585:THITH_RS04620
uniprot id: W0DH23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

713585:THITH RS16860
gene id: 713585:THITH_RS16860
uniprot id: W0DSE3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

713585:THITH RS14845
gene id: 713585:THITH_RS14845
uniprot id: W0DQZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

713585:THITH RS00245
gene id: 713585:THITH_RS00245
uniprot id: W0DIX8
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

713585:THITH RS02935
gene id: 713585:THITH_RS02935
uniprot id: W0DFJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

713585:THITH RS08635
gene id: 713585:THITH_RS08635
uniprot id: W0DMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

713585:THITH RS14265
gene id: 713585:THITH_RS14265
uniprot id: W0DLK4
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

713585:THITH RS10410
gene id: 713585:THITH_RS10410
uniprot id: W0DP45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

713585:THITH RS14375
gene id: 713585:THITH_RS14375
uniprot id: W0DLM1
names: Similarity
messages: Belongs to the peptidase M1 family.

713585:THITH RS13030
gene id: 713585:THITH_RS13030
uniprot id: W0DKH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

713585:THITH RS00095
gene id: 713585:THITH_RS00095
uniprot id: W0DS43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS08395
gene id: 713585:THITH_RS08395
uniprot id: W0DI70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS01450
gene id: 713585:THITH_RS01450
uniprot id: W0DFQ7
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

713585:THITH RS16655
gene id: 713585:THITH_RS16655
uniprot id: W0DR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

713585:THITH RS06265
gene id: 713585:THITH_RS06265
uniprot id: W0DLT9
names: Similarity
messages: Belongs to the peptidase A31 family.

713585:THITH RS02460
gene id: 713585:THITH_RS02460
uniprot id: W0DJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

713585:THITH RS11680
gene id: 713585:THITH_RS11680
uniprot id: W0DNP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

713585:THITH RS03550
gene id: 713585:THITH_RS03550
uniprot id: W0DJT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS16800
gene id: 713585:THITH_RS16800
uniprot id: W0DS16
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

713585:THITH RS00445
gene id: 713585:THITH_RS00445
uniprot id: W0DF54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

713585:THITH RS15565
gene id: 713585:THITH_RS15565
uniprot id: W0DQL0
names: Similarity
messages: Belongs to the GSP E family.

713585:THITH RS00710
gene id: 713585:THITH_RS00710
uniprot id: W0DJH9
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

713585:THITH RS11665
gene id: 713585:THITH_RS11665
uniprot id: W0DJS7
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

713585:THITH RS07095
gene id: 713585:THITH_RS07095
uniprot id: W0DMI2
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS15870
gene id: 713585:THITH_RS15870
uniprot id: W0DMB9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

713585:THITH RS01845
gene id: 713585:THITH_RS01845
uniprot id: W0DJ28
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

713585:THITH RS13750
gene id: 713585:THITH_RS13750
uniprot id: W0DPS2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS01295
gene id: 713585:THITH_RS01295
uniprot id: W0DJS6
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

713585:THITH RS15035
gene id: 713585:THITH_RS15035
uniprot id: W0DRG2
names: Similarity
messages: Belongs to the P(II) protein family.

713585:THITH RS08860
gene id: 713585:THITH_RS08860
uniprot id: W0DIE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

713585:THITH RS14045
gene id: 713585:THITH_RS14045
uniprot id: W0DLG5
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

713585:THITH RS12715
gene id: 713585:THITH_RS12715
uniprot id: W0DKB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

713585:THITH RS16515
gene id: 713585:THITH_RS16515
uniprot id: W0DMP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

713585:THITH RS15650
gene id: 713585:THITH_RS15650
uniprot id: W0DQM4
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

713585:THITH RS06095
gene id: 713585:THITH_RS06095
uniprot id: W0DL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

713585:THITH RS12710
gene id: 713585:THITH_RS12710
uniprot id: W0DPW7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

713585:THITH RS08540
gene id: 713585:THITH_RS08540
uniprot id: W0DMY2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS11355
gene id: 713585:THITH_RS11355
uniprot id: W0DNJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS00920
gene id: 713585:THITH_RS00920
uniprot id: W0DEK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

713585:THITH RS04840
gene id: 713585:THITH_RS04840
uniprot id: W0DL63
names: Similarity
messages: Belongs to the histone deacetylase family.

713585:THITH RS13065
gene id: 713585:THITH_RS13065
uniprot id: W0DKW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

713585:THITH RS16825
gene id: 713585:THITH_RS16825
uniprot id: W0DS20
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

713585:THITH RS15970
gene id: 713585:THITH_RS15970
uniprot id: W0DM06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

713585:THITH RS02625
gene id: 713585:THITH_RS02625
uniprot id: W0DKE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

713585:THITH RS12625
gene id: 713585:THITH_RS12625
uniprot id: W0DQ79
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS08525
gene id: 713585:THITH_RS08525
uniprot id: W0DN83
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

713585:THITH RS03755
gene id: 713585:THITH_RS03755
uniprot id: W0DGN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

713585:THITH RS09305
gene id: 713585:THITH_RS09305
uniprot id: W0DIN4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

713585:THITH RS02400
gene id: 713585:THITH_RS02400
uniprot id: W0DKA9
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

713585:THITH RS16455
gene id: 713585:THITH_RS16455
uniprot id: W0DMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

713585:THITH RS01460
gene id: 713585:THITH_RS01460
uniprot id: W0DJM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

713585:THITH RS08320
gene id: 713585:THITH_RS08320
uniprot id: W0DN45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

713585:THITH RS03395
gene id: 713585:THITH_RS03395
uniprot id: W0DKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

713585:THITH RS01245
gene id: 713585:THITH_RS01245
uniprot id: W0DFJ0
names: Subcellular Location Annotation
messages: Cytoplasm

713585:THITH RS11790
gene id: 713585:THITH_RS11790
uniprot id: W0DPG0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

713585:THITH RS06160
gene id: 713585:THITH_RS06160
uniprot id: W0DH32
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS09660
gene id: 713585:THITH_RS09660
uniprot id: W0DIU0
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

713585:THITH RS06025
gene id: 713585:THITH_RS06025
uniprot id: W0DH06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

713585:THITH RS13880
gene id: 713585:THITH_RS13880
uniprot id: W0DQJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

713585:THITH RS12645
gene id: 713585:THITH_RS12645
uniprot id: W0DKA6
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS08490
gene id: 713585:THITH_RS08490
uniprot id: W0DMX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15845
gene id: 713585:THITH_RS15845
uniprot id: W0DMB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

713585:THITH RS16420
gene id: 713585:THITH_RS16420
uniprot id: W0DR39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

713585:THITH RS16940
gene id: 713585:THITH_RS16940
uniprot id: W0DSF7
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

713585:THITH RS11475
gene id: 713585:THITH_RS11475
uniprot id: W0DNK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS15840
gene id: 713585:THITH_RS15840
uniprot id: W0DRV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

713585:THITH RS13775
gene id: 713585:THITH_RS13775
uniprot id: W0DPS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

713585:THITH RS16935
gene id: 713585:THITH_RS16935
uniprot id: W0DMH5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

713585:THITH RS02100
gene id: 713585:THITH_RS02100
uniprot id: W0DK62
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS15720
gene id: 713585:THITH_RS15720
uniprot id: W0DRF4
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

713585:THITH RS06965
gene id: 713585:THITH_RS06965
uniprot id: W0DMF8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

713585:THITH RS08500
gene id: 713585:THITH_RS08500
uniprot id: W0DN78
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

713585:THITH RS13195
gene id: 713585:THITH_RS13195
uniprot id: W0DKZ1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

713585:THITH RS00100
gene id: 713585:THITH_RS00100
uniprot id: W0DMI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

713585:THITH RS01750
gene id: 713585:THITH_RS01750
uniprot id: W0DJ15
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

713585:THITH RS03525
gene id: 713585:THITH_RS03525
uniprot id: W0DJT3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS16075
gene id: 713585:THITH_RS16075
uniprot id: W0DS03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

713585:THITH RS07500
gene id: 713585:THITH_RS07500
uniprot id: W0DMH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

713585:THITH RS15960
gene id: 713585:THITH_RS15960
uniprot id: W0DQT7
names: Similarity
messages: Belongs to the peptidase M16 family.

713585:THITH RS07960
gene id: 713585:THITH_RS07960
uniprot id: W0DLY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

713585:THITH RS09720
gene id: 713585:THITH_RS09720
uniprot id: W0DNG5
names: Similarity
messages: Belongs to the disproportionating enzyme family.

713585:THITH RS14540
gene id: 713585:THITH_RS14540
uniprot id: W0DLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

713585:THITH RS00540
gene id: 713585:THITH_RS00540
uniprot id: W0DF73
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS02420
gene id: 713585:THITH_RS02420
uniprot id: W0DFC2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

713585:THITH RS05155
gene id: 713585:THITH_RS05155
uniprot id: W0DLA9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

713585:THITH RS00140
gene id: 713585:THITH_RS00140
uniprot id: W0DIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane
messages: Membrane

713585:THITH RS07655
gene id: 713585:THITH_RS07655
uniprot id: W0DMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

713585:THITH RS11690
gene id: 713585:THITH_RS11690
uniprot id: W0DJT1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

713585:THITH RS00130
gene id: 713585:THITH_RS00130
uniprot id: W0DF04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

713585:THITH RS04000
gene id: 713585:THITH_RS04000
uniprot id: W0DL15
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS02740
gene id: 713585:THITH_RS02740
uniprot id: W0DG99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS02685
gene id: 713585:THITH_RS02685
uniprot id: W0DG90
names: Similarity
messages: Belongs to the peptidase U62 family.

713585:THITH RS16470
gene id: 713585:THITH_RS16470
uniprot id: W0DR47
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

713585:THITH RS15985
gene id: 713585:THITH_RS15985
uniprot id: W0DQU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

713585:THITH RS12575
gene id: 713585:THITH_RS12575
uniprot id: W0DKN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS01260
gene id: 713585:THITH_RS01260
uniprot id: W0DJF8
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS14460
gene id: 713585:THITH_RS14460
uniprot id: W0DR74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS15050
gene id: 713585:THITH_RS15050
uniprot id: W0DR26
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

713585:THITH RS09910
gene id: 713585:THITH_RS09910
uniprot id: W0DIX6
names: Subcellular Location Annotation
messages: Cytoplasm

713585:THITH RS07925
gene id: 713585:THITH_RS07925
uniprot id: W0DMZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

713585:THITH RS16590
gene id: 713585:THITH_RS16590
uniprot id: W0DSB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

713585:THITH RS10135
gene id: 713585:THITH_RS10135
uniprot id: W0DNM3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

713585:THITH RS11500
gene id: 713585:THITH_RS11500
uniprot id: W0DNL1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

713585:THITH RS12495
gene id: 713585:THITH_RS12495
uniprot id: W0DKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

713585:THITH RS14520
gene id: 713585:THITH_RS14520
uniprot id: W0DQ46
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

713585:THITH RS13840
gene id: 713585:THITH_RS13840
uniprot id: W0DQX2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

713585:THITH RS03430
gene id: 713585:THITH_RS03430
uniprot id: W0DFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

713585:THITH RS04345
gene id: 713585:THITH_RS04345
uniprot id: W0DGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS04290
gene id: 713585:THITH_RS04290
uniprot id: W0DGX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS10715
gene id: 713585:THITH_RS10715
uniprot id: W0DNZ3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

713585:THITH RS12365
gene id: 713585:THITH_RS12365
uniprot id: W0DQ28
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS15415
gene id: 713585:THITH_RS15415
uniprot id: W0DR99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

713585:THITH RS06710
gene id: 713585:THITH_RS06710
uniprot id: W0DMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

713585:THITH RS09135
gene id: 713585:THITH_RS09135
uniprot id: W0DNJ2
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

713585:THITH RS13000
gene id: 713585:THITH_RS13000
uniprot id: W0DKG5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

713585:THITH RS07710
gene id: 713585:THITH_RS07710
uniprot id: W0DMK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS15975
gene id: 713585:THITH_RS15975
uniprot id: W0DRX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

713585:THITH RS07940
gene id: 713585:THITH_RS07940
uniprot id: W0DMN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

713585:THITH RS14320
gene id: 713585:THITH_RS14320
uniprot id: W0DQ12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

713585:THITH RS15765
gene id: 713585:THITH_RS15765
uniprot id: W0DQP5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

713585:THITH RS13890
gene id: 713585:THITH_RS13890
uniprot id: W0DQY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

713585:THITH RS16730
gene id: 713585:THITH_RS16730
uniprot id: W0DSC8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

713585:THITH RS11050
gene id: 713585:THITH_RS11050
uniprot id: W0DPI0
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

713585:THITH RS08800
gene id: 713585:THITH_RS08800
uniprot id: W0DN26
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

713585:THITH RS14550
gene id: 713585:THITH_RS14550
uniprot id: W0DQV4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

713585:THITH RS10100
gene id: 713585:THITH_RS10100
uniprot id: W0DNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

713585:THITH RS09325
gene id: 713585:THITH_RS09325
uniprot id: W0DNB5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

713585:THITH RS07630
gene id: 713585:THITH_RS07630
uniprot id: W0DMJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

713585:THITH RS16790
gene id: 713585:THITH_RS16790
uniprot id: W0DMU0
names: Similarity
messages: Belongs to the DEAD box helicase family.

713585:THITH RS07060
gene id: 713585:THITH_RS07060
uniprot id: W0DM79
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

713585:THITH RS13225
gene id: 713585:THITH_RS13225
uniprot id: W0DPF6
names: Similarity
messages: Belongs to the HSP15 family.

713585:THITH RS07595
gene id: 713585:THITH_RS07595
uniprot id: W0DLT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

713585:THITH RS15885
gene id: 713585:THITH_RS15885
uniprot id: W0DLY8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

713585:THITH RS13040
gene id: 713585:THITH_RS13040
uniprot id: W0DKW2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

713585:THITH RS13060
gene id: 713585:THITH_RS13060
uniprot id: W0DQE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS04945
gene id: 713585:THITH_RS04945
uniprot id: W0DGJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

713585:THITH RS04930
gene id: 713585:THITH_RS04930
uniprot id: W0DH68
names: Caution
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

713585:THITH RS12790
gene id: 713585:THITH_RS12790
uniprot id: W0DPY1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

713585:THITH RS00515
gene id: 713585:THITH_RS00515
uniprot id: W0DF68
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

713585:THITH RS16290
gene id: 713585:THITH_RS16290
uniprot id: W0DR28
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS08185
gene id: 713585:THITH_RS08185
uniprot id: W0DN97
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

713585:THITH RS04005
gene id: 713585:THITH_RS04005
uniprot id: W0DGT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS09105
gene id: 713585:THITH_RS09105
uniprot id: W0DIJ0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

713585:THITH RS11035
gene id: 713585:THITH_RS11035
uniprot id: W0DNE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

713585:THITH RS02580
gene id: 713585:THITH_RS02580
uniprot id: W0DG74
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

713585:THITH RS02810
gene id: 713585:THITH_RS02810
uniprot id: W0DKI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

713585:THITH RS13835
gene id: 713585:THITH_RS13835
uniprot id: W0DKZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

713585:THITH RS08890
gene id: 713585:THITH_RS08890
uniprot id: W0DNF4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

713585:THITH RS12300
gene id: 713585:THITH_RS12300
uniprot id: W0DTN8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS02975
gene id: 713585:THITH_RS02975
uniprot id: W0DK98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

713585:THITH RS14030
gene id: 713585:THITH_RS14030
uniprot id: W0DQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

713585:THITH RS08455
gene id: 713585:THITH_RS08455
uniprot id: W0DIR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

713585:THITH RS09655
gene id: 713585:THITH_RS09655
uniprot id: W0DNF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

713585:THITH RS00825
gene id: 713585:THITH_RS00825
uniprot id: W0DS64
names: Similarity
messages: Belongs to the cytochrome P450 family.

713585:THITH RS05115
gene id: 713585:THITH_RS05115
uniprot id: W0DLL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

713585:THITH RS06525
gene id: 713585:THITH_RS06525
uniprot id: W0DL60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

713585:THITH RS03935
gene id: 713585:THITH_RS03935
uniprot id: W0DKP3
names: Subcellular Location Annotation
messages: Cell inner membrane

713585:THITH RS04915
gene id: 713585:THITH_RS04915
uniprot id: W0DL82
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

713585:THITH RS04390
gene id: 713585:THITH_RS04390
uniprot id: W0DL96
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

713585:THITH RS14035
gene id: 713585:THITH_RS14035
uniprot id: W0DL22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

713585:THITH RS04215
gene id: 713585:THITH_RS04215
uniprot id: W0DK53
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

713585:THITH RS00455
gene id: 713585:THITH_RS00455
uniprot id: W0DJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

713585:THITH RS03410
gene id: 713585:THITH_RS03410
uniprot id: W0DGJ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

713585:THITH RS12475
gene id: 713585:THITH_RS12475
uniprot id: W0DP14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

713585:THITH RS14300
gene id: 713585:THITH_RS14300
uniprot id: W0DQR1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

713585:THITH RS05925
gene id: 713585:THITH_RS05925
uniprot id: W0DHK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

713585:THITH RS11655
gene id: 713585:THITH_RS11655
uniprot id: W0DNN6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

713585:THITH RS05400
gene id: 713585:THITH_RS05400
uniprot id: W0DLQ7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS11315
gene id: 713585:THITH_RS11315
uniprot id: W0DJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

713585:THITH RS08765
gene id: 713585:THITH_RS08765
uniprot id: W0DMA0
names: Similarity
messages: Belongs to the glutamate synthase family.

713585:THITH RS04035
gene id: 713585:THITH_RS04035
uniprot id: W0DK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

713585:THITH RS08130
gene id: 713585:THITH_RS08130
uniprot id: W0DN24
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

713585:THITH RS08770
gene id: 713585:THITH_RS08770
uniprot id: W0DN22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS00620
gene id: 713585:THITH_RS00620
uniprot id: W0DIE1
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS01255
gene id: 713585:THITH_RS01255
uniprot id: W0DIQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

713585:THITH RS00040
gene id: 713585:THITH_RS00040
uniprot id: W0DI42
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

713585:THITH RS04495
gene id: 713585:THITH_RS04495
uniprot id: W0DH10
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

713585:THITH RS01985
gene id: 713585:THITH_RS01985
uniprot id: W0DJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

713585:THITH RS06470
gene id: 713585:THITH_RS06470
uniprot id: W0DL53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

713585:THITH RS11735
gene id: 713585:THITH_RS11735
uniprot id: W0DPF1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

713585:THITH RS07370
gene id: 713585:THITH_RS07370
uniprot id: W0DME7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

713585:THITH RS12400
gene id: 713585:THITH_RS12400
uniprot id: W0DKJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

713585:THITH RS10635
gene id: 713585:THITH_RS10635
uniprot id: W0DT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

713585:THITH RS13190
gene id: 713585:THITH_RS13190
uniprot id: W0DQH6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

713585:THITH RS11860
gene id: 713585:THITH_RS11860
uniprot id: W0DKB8
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

713585:THITH RS09650
gene id: 713585:THITH_RS09650
uniprot id: W0DMN0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

713585:THITH RS02435
gene id: 713585:THITH_RS02435
uniprot id: W0DJB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS15130
gene id: 713585:THITH_RS15130
uniprot id: W0DR45
names: Similarity
messages: Belongs to the Smg family.

713585:THITH RS16920
gene id: 713585:THITH_RS16920
uniprot id: W0DMV9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

713585:THITH RS07225
gene id: 713585:THITH_RS07225
uniprot id: W0DLJ2
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

713585:THITH RS16950
gene id: 713585:THITH_RS16950
uniprot id: W0DRB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

713585:THITH RS01115
gene id: 713585:THITH_RS01115
uniprot id: W0DEN8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS07315
gene id: 713585:THITH_RS07315
uniprot id: W0DLK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

713585:THITH RS08460
gene id: 713585:THITH_RS08460
uniprot id: W0DM53
names: Similarity
messages: Belongs to the fabD family.

713585:THITH RS16345
gene id: 713585:THITH_RS16345
uniprot id: W0DS75
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03450
gene id: 713585:THITH_RS03450
uniprot id: W0DKF7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

713585:THITH RS01880
gene id: 713585:THITH_RS01880
uniprot id: W0DFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

713585:THITH RS06315
gene id: 713585:THITH_RS06315
uniprot id: W0DH59
names: Similarity
messages: Belongs to the YkuD family.

713585:THITH RS10390
gene id: 713585:THITH_RS10390
uniprot id: W0DN13
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS10310
gene id: 713585:THITH_RS10310
uniprot id: W0DMZ3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

713585:THITH RS00760
gene id: 713585:THITH_RS00760
uniprot id: W0DEI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

713585:THITH RS06105
gene id: 713585:THITH_RS06105
uniprot id: W0DH19
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

713585:THITH RS15030
gene id: 713585:THITH_RS15030
uniprot id: W0DLH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

713585:THITH RS08795
gene id: 713585:THITH_RS08795
uniprot id: W0DMA7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

713585:THITH RS03780
gene id: 713585:THITH_RS03780
uniprot id: W0DKX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

713585:THITH RS10915
gene id: 713585:THITH_RS10915
uniprot id: W0DPF7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

713585:THITH RS12510
gene id: 713585:THITH_RS12510
uniprot id: W0DPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

713585:THITH RS16080
gene id: 713585:THITH_RS16080
uniprot id: W0DMG0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

713585:THITH RS15725
gene id: 713585:THITH_RS15725
uniprot id: W0DLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

713585:THITH RS00380
gene id: 713585:THITH_RS00380
uniprot id: W0DEB4
names: Subcellular Location Annotation
messages: Membrane

713585:THITH RS14305
gene id: 713585:THITH_RS14305
uniprot id: W0DL62
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

713585:THITH RS06260
gene id: 713585:THITH_RS06260
uniprot id: W0DL27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

713585:THITH RS13860
gene id: 713585:THITH_RS13860
uniprot id: W0DKZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

713585:THITH RS08955
gene id: 713585:THITH_RS08955
uniprot id: W0DNG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

713585:THITH RS02350
gene id: 713585:THITH_RS02350
uniprot id: W0DKA0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

713585:THITH RS15250
gene id: 713585:THITH_RS15250
uniprot id: W0DTU2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

713585:THITH RS15020
gene id: 713585:THITH_RS15020
uniprot id: W0DQB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

713585:THITH RS15895
gene id: 713585:THITH_RS15895
uniprot id: W0DMC5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

713585:THITH RS10770
gene id: 713585:THITH_RS10770
uniprot id: W0DNA0
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

713585:THITH RS07050
gene id: 713585:THITH_RS07050
uniprot id: W0DI58
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

713585:THITH RS03895
gene id: 713585:THITH_RS03895
uniprot id: W0DKZ2
names: Similarity
messages: Belongs to the RecJ family.

713585:THITH RS05930
gene id: 713585:THITH_RS05930
uniprot id: W0DKY6
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

713585:THITH RS13865
gene id: 713585:THITH_RS13865
uniprot id: W0DQX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

713585:THITH RS09140
gene id: 713585:THITH_RS09140
uniprot id: W0DJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS00720
gene id: 713585:THITH_RS00720
uniprot id: W0DIF3
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

713585:THITH RS05070
gene id: 713585:THITH_RS05070
uniprot id: W0DL98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

713585:THITH RS15695
gene id: 713585:THITH_RS15695
uniprot id: W0DRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

713585:THITH RS11365
gene id: 713585:THITH_RS11365
uniprot id: W0DJM7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

713585:THITH RS04395
gene id: 713585:THITH_RS04395
uniprot id: W0DGZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

713585:THITH RS10730
gene id: 713585:THITH_RS10730
uniprot id: W0DJE1
names: Similarity
messages: Belongs to the YoeB family.

713585:THITH RS13855
gene id: 713585:THITH_RS13855
uniprot id: W0DQJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm