710696:INTCA RS05340
gene id: 710696:INTCA_RS05340
uniprot id: E6SDG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

710696:INTCA RS07895
gene id: 710696:INTCA_RS07895
uniprot id: E6S8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

710696:INTCA RS02485
gene id: 710696:INTCA_RS02485
uniprot id: E6S8R7
names: Similarity
messages: Belongs to the peptidase S8 family.

710696:INTCA RS15430
gene id: 710696:INTCA_RS15430
uniprot id: E6SC03
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

710696:INTCA RS14125
gene id: 710696:INTCA_RS14125
uniprot id: E6S9Q9
names: Similarity
messages: Belongs to the UPF0336 family.

710696:INTCA RS08815
gene id: 710696:INTCA_RS08815
uniprot id: E6SA44
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS11805
gene id: 710696:INTCA_RS11805
uniprot id: E6SFQ9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

710696:INTCA RS03315
gene id: 710696:INTCA_RS03315
uniprot id: E6SAF3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

710696:INTCA RS06820
gene id: 710696:INTCA_RS06820
uniprot id: E6S6B4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

710696:INTCA RS08940
gene id: 710696:INTCA_RS08940
uniprot id: E6SA67
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

710696:INTCA RS14790
gene id: 710696:INTCA_RS14790
uniprot id: E6SAV8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS05890
gene id: 710696:INTCA_RS05890
uniprot id: E6SET5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

710696:INTCA RS11940
gene id: 710696:INTCA_RS11940
uniprot id: E6SFT1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06155
gene id: 710696:INTCA_RS06155
uniprot id: E6SFJ7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

710696:INTCA RS18360
gene id: 710696:INTCA_RS18360
uniprot id: E6S7F7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

710696:INTCA RS03160
gene id: 710696:INTCA_RS03160
uniprot id: E6S9Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

710696:INTCA RS14555
gene id: 710696:INTCA_RS14555
uniprot id: E6SAD0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS10710
gene id: 710696:INTCA_RS10710
uniprot id: E6SD33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS17645
gene id: 710696:INTCA_RS17645
uniprot id: E6SG24
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

710696:INTCA RS06205
gene id: 710696:INTCA_RS06205
uniprot id: E6SFK7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS05370
gene id: 710696:INTCA_RS05370
uniprot id: E6SDG9
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cyclic amide hydrolase (CyAH) family.
messages: Homotetramer.
messages: Inhibited by cyanuric acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid.
messages: The monomer structure is formed from three repeating units (RUs) that share the same structure as one another. The monomer and the active site possess nearly threefold rotational symmetry, to the extent that the active site possesses three potential Ser-Lys catalytic dyads, but one of the 3 active site surfaces varies in composition suggesting it is involved in confering substrate specificity.

710696:INTCA RS17935
gene id: 710696:INTCA_RS17935
uniprot id: E6S6M0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

710696:INTCA RS11965
gene id: 710696:INTCA_RS11965
uniprot id: E6SFT5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

710696:INTCA RS11900
gene id: 710696:INTCA_RS11900
uniprot id: E6SFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS10625
gene id: 710696:INTCA_RS10625
uniprot id: E6SD16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS00255
gene id: 710696:INTCA_RS00255
uniprot id: E6SEL0
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

710696:INTCA RS11560
gene id: 710696:INTCA_RS11560
uniprot id: E6SF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS09790
gene id: 710696:INTCA_RS09790
uniprot id: E6SBT0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

710696:INTCA RS05590
gene id: 710696:INTCA_RS05590
uniprot id: E6SE19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

710696:INTCA RS01110
gene id: 710696:INTCA_RS01110
uniprot id: E6S637
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

710696:INTCA RS14825
gene id: 710696:INTCA_RS14825
uniprot id: E6SAW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

710696:INTCA RS05900
gene id: 710696:INTCA_RS05900
uniprot id: E6SET7
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

710696:INTCA RS09330
gene id: 710696:INTCA_RS09330
uniprot id: E6SB65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

710696:INTCA RS06015
gene id: 710696:INTCA_RS06015
uniprot id: E6SEW0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13655
gene id: 710696:INTCA_RS13655
uniprot id: E6S928
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

710696:INTCA RS10940
gene id: 710696:INTCA_RS10940
uniprot id: E6SDL4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

710696:INTCA RS00150
gene id: 710696:INTCA_RS00150
uniprot id: E6SEI8
names: Similarity
messages: Belongs to the peptidase C40 family.

710696:INTCA RS03470
gene id: 710696:INTCA_RS03470
uniprot id: E6SAI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS17195
gene id: 710696:INTCA_RS17195
uniprot id: E6SF75
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13685
gene id: 710696:INTCA_RS13685
uniprot id: E6S934
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

710696:INTCA RS14260
gene id: 710696:INTCA_RS14260
uniprot id: E6SA74
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

710696:INTCA RS00795
gene id: 710696:INTCA_RS00795
uniprot id: E6SFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

710696:INTCA RS18080
gene id: 710696:INTCA_RS18080
uniprot id: E6S6Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

710696:INTCA RS18285
gene id: 710696:INTCA_RS18285
uniprot id: E6S7E5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS13920
gene id: 710696:INTCA_RS13920
uniprot id: E6S9L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS07615
gene id: 710696:INTCA_RS07615
uniprot id: E6S898
names: Similarity
messages: Belongs to the universal stress protein A family.

710696:INTCA RS02530
gene id: 710696:INTCA_RS02530
uniprot id: E6S8S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

710696:INTCA RS12420
gene id: 710696:INTCA_RS12420
uniprot id: E6S6G7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS09360
gene id: 710696:INTCA_RS09360
uniprot id: E6SB71
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

710696:INTCA RS03050
gene id: 710696:INTCA_RS03050
uniprot id: E6S9V8
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: In the N-terminal section; belongs to the DHNA family.

710696:INTCA RS14545
gene id: 710696:INTCA_RS14545
uniprot id: E6SAC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS01550
gene id: 710696:INTCA_RS01550
uniprot id: E6S7G3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

710696:INTCA RS04815
gene id: 710696:INTCA_RS04815
uniprot id: E6SCS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

710696:INTCA RS03495
gene id: 710696:INTCA_RS03495
uniprot id: E6SAI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS18075
gene id: 710696:INTCA_RS18075
uniprot id: E6S6P9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

710696:INTCA RS06470
gene id: 710696:INTCA_RS06470
uniprot id: E6S654
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11375
gene id: 710696:INTCA_RS11375
uniprot id: E6SEA4
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS02880
gene id: 710696:INTCA_RS02880
uniprot id: E6S9D9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS07840
gene id: 710696:INTCA_RS07840
uniprot id: E6S8E0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

710696:INTCA RS10305
gene id: 710696:INTCA_RS10305
uniprot id: E6SCG3
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

710696:INTCA RS07880
gene id: 710696:INTCA_RS07880
uniprot id: E6S8E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

710696:INTCA RS09695
gene id: 710696:INTCA_RS09695
uniprot id: E6SBR1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03265
gene id: 710696:INTCA_RS03265
uniprot id: E6SAE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS09305
gene id: 710696:INTCA_RS09305
uniprot id: E6SAS5
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

710696:INTCA RS11300
gene id: 710696:INTCA_RS11300
uniprot id: E6SE89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

710696:INTCA RS13640
gene id: 710696:INTCA_RS13640
uniprot id: E6S925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS07885
gene id: 710696:INTCA_RS07885
uniprot id: E6S8E9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

710696:INTCA RS05190
gene id: 710696:INTCA_RS05190
uniprot id: E6SDD1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS00715
gene id: 710696:INTCA_RS00715
uniprot id: E6SFG4
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

710696:INTCA RS20240
gene id: 710696:INTCA_RS20240
uniprot id: E6SCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS13000
gene id: 710696:INTCA_RS13000
uniprot id: E6S7X5
names: Similarity
messages: Belongs to the DEAD box helicase family.

710696:INTCA RS01305
gene id: 710696:INTCA_RS01305
uniprot id: E6S6S7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS01265
gene id: 710696:INTCA_RS01265
uniprot id: E6S6S1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

710696:INTCA RS12480
gene id: 710696:INTCA_RS12480
uniprot id: E6S6H8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

710696:INTCA RS08135
gene id: 710696:INTCA_RS08135
uniprot id: E6S8Y0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS13935
gene id: 710696:INTCA_RS13935
uniprot id: E6S9M1
names: Similarity
messages: Belongs to the peptidase M18 family.

710696:INTCA RS13890
gene id: 710696:INTCA_RS13890
uniprot id: E6S975
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS04475
gene id: 710696:INTCA_RS04475
uniprot id: E6SC73
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

710696:INTCA RS14535
gene id: 710696:INTCA_RS14535
uniprot id: E6SAC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

710696:INTCA RS10330
gene id: 710696:INTCA_RS10330
uniprot id: E6SCG8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

710696:INTCA RS15120
gene id: 710696:INTCA_RS15120
uniprot id: E6SBF5
names: Similarity
messages: Belongs to the CsoR family.

710696:INTCA RS13780
gene id: 710696:INTCA_RS13780
uniprot id: E6S953
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

710696:INTCA RS05200
gene id: 710696:INTCA_RS05200
uniprot id: E6SDD3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

710696:INTCA RS00435
gene id: 710696:INTCA_RS00435
uniprot id: E6SEP5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS03650
gene id: 710696:INTCA_RS03650
uniprot id: E6SB06
names: Similarity
messages: Belongs to the peptidase M1 family.

710696:INTCA RS08915
gene id: 710696:INTCA_RS08915
uniprot id: E6SA62
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS16765
gene id: 710696:INTCA_RS16765
uniprot id: E6SEC6
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

710696:INTCA RS05635
gene id: 710696:INTCA_RS05635
uniprot id: E6SE28
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

710696:INTCA RS10420
gene id: 710696:INTCA_RS10420
uniprot id: E6SCX6
names: Similarity
messages: Belongs to the leucine-binding protein family.

710696:INTCA RS14075
gene id: 710696:INTCA_RS14075
uniprot id: E6S9Q0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

710696:INTCA RS20095
gene id: 710696:INTCA_RS20095
uniprot id: E6SFI7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS09605
gene id: 710696:INTCA_RS09605
uniprot id: E6SBB8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS16555
gene id: 710696:INTCA_RS16555
uniprot id: E6SDT1
names: Similarity
messages: Belongs to the LppX/LprAFG lipoprotein family.

710696:INTCA RS09945
gene id: 710696:INTCA_RS09945
uniprot id: E6SBW1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

710696:INTCA RS04055
gene id: 710696:INTCA_RS04055
uniprot id: E6SBK8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS06875
gene id: 710696:INTCA_RS06875
uniprot id: E6S6Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

710696:INTCA RS16550
gene id: 710696:INTCA_RS16550
uniprot id: E6SDT0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS02505
gene id: 710696:INTCA_RS02505
uniprot id: E6S8S1
names: Similarity
messages: Belongs to the UPF0098 family.

710696:INTCA RS10425
gene id: 710696:INTCA_RS10425
uniprot id: E6SCX7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13810
gene id: 710696:INTCA_RS13810
uniprot id: E6S959
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

710696:INTCA RS05535
gene id: 710696:INTCA_RS05535
uniprot id: E6SE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS08515
gene id: 710696:INTCA_RS08515
uniprot id: E6S9J8
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

710696:INTCA RS08730
gene id: 710696:INTCA_RS08730
uniprot id: E6SA27
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

710696:INTCA RS13250
gene id: 710696:INTCA_RS13250
uniprot id: E6S8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS04035
gene id: 710696:INTCA_RS04035
uniprot id: E6SBK4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

710696:INTCA RS12410
gene id: 710696:INTCA_RS12410
uniprot id: E6S6G5
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

710696:INTCA RS08105
gene id: 710696:INTCA_RS08105
uniprot id: E6S8X4
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

710696:INTCA RS04165
gene id: 710696:INTCA_RS04165
uniprot id: E6SBN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

710696:INTCA RS18230
gene id: 710696:INTCA_RS18230
uniprot id: E6S7D3
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

710696:INTCA RS13370
gene id: 710696:INTCA_RS13370
uniprot id: E6S8I6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

710696:INTCA RS08050
gene id: 710696:INTCA_RS08050
uniprot id: E6S8W3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

710696:INTCA RS13430
gene id: 710696:INTCA_RS13430
uniprot id: E6S8J9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04990
gene id: 710696:INTCA_RS04990
uniprot id: E6SCV9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

710696:INTCA RS04725
gene id: 710696:INTCA_RS04725
uniprot id: E6SCQ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS16020
gene id: 710696:INTCA_RS16020
uniprot id: E6SD39
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS07985
gene id: 710696:INTCA_RS07985
uniprot id: E6S8V0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS16275
gene id: 710696:INTCA_RS16275
uniprot id: E6SD90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

710696:INTCA RS06515
gene id: 710696:INTCA_RS06515
uniprot id: E6S662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

710696:INTCA RS15260
gene id: 710696:INTCA_RS15260
uniprot id: E6SBI2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03795
gene id: 710696:INTCA_RS03795
uniprot id: E6SB35
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS13760
gene id: 710696:INTCA_RS13760
uniprot id: E6S949
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

710696:INTCA RS11265
gene id: 710696:INTCA_RS11265
uniprot id: E6SE83
names: Similarity
messages: Belongs to the ribF family.

710696:INTCA RS12145
gene id: 710696:INTCA_RS12145
uniprot id: E6SFX1
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

710696:INTCA RS10240
gene id: 710696:INTCA_RS10240
uniprot id: E6SCF0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

710696:INTCA RS09390
gene id: 710696:INTCA_RS09390
uniprot id: E6SB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

710696:INTCA RS10430
gene id: 710696:INTCA_RS10430
uniprot id: E6SCX8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS15305
gene id: 710696:INTCA_RS15305
uniprot id: E6SBJ1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

710696:INTCA RS00395
gene id: 710696:INTCA_RS00395
uniprot id: E6SEN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS18295
gene id: 710696:INTCA_RS18295
uniprot id: E6S7E7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

710696:INTCA RS00805
gene id: 710696:INTCA_RS00805
uniprot id: E6SFI2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

710696:INTCA RS12190
gene id: 710696:INTCA_RS12190
uniprot id: E6S6C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

710696:INTCA RS03180
gene id: 710696:INTCA_RS03180
uniprot id: E6S9Y5
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

710696:INTCA RS11490
gene id: 710696:INTCA_RS11490
uniprot id: E6SEY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

710696:INTCA RS13605
gene id: 710696:INTCA_RS13605
uniprot id: E6S918
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

710696:INTCA RS10700
gene id: 710696:INTCA_RS10700
uniprot id: E6SD31
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

710696:INTCA RS13235
gene id: 710696:INTCA_RS13235
uniprot id: E6S8F7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

710696:INTCA RS03040
gene id: 710696:INTCA_RS03040
uniprot id: E6S9V6
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

710696:INTCA RS03630
gene id: 710696:INTCA_RS03630
uniprot id: E6SB02
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04015
gene id: 710696:INTCA_RS04015
uniprot id: E6SBK0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS02155
gene id: 710696:INTCA_RS02155
uniprot id: E6S866
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17490
gene id: 710696:INTCA_RS17490
uniprot id: E6SFZ3
names: Similarity
messages: Belongs to the CFA/CMAS family.

710696:INTCA RS12170
gene id: 710696:INTCA_RS12170
uniprot id: E6S6B6
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

710696:INTCA RS05305
gene id: 710696:INTCA_RS05305
uniprot id: E6SDF6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

710696:INTCA RS09400
gene id: 710696:INTCA_RS09400
uniprot id: E6SB80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

710696:INTCA RS07110
gene id: 710696:INTCA_RS07110
uniprot id: E6S726
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

710696:INTCA RS01505
gene id: 710696:INTCA_RS01505
uniprot id: E6S6W3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

710696:INTCA RS15295
gene id: 710696:INTCA_RS15295
uniprot id: E6SBI9
names: Similarity
messages: Belongs to the CdaR family.

710696:INTCA RS07720
gene id: 710696:INTCA_RS07720
uniprot id: E6S8B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

710696:INTCA RS06580
gene id: 710696:INTCA_RS06580
uniprot id: E6S673
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

710696:INTCA RS13490
gene id: 710696:INTCA_RS13490
uniprot id: E6S8K9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS09410
gene id: 710696:INTCA_RS09410
uniprot id: E6SB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

710696:INTCA RS13050
gene id: 710696:INTCA_RS13050
uniprot id: E6S7Y6
names: Similarity
messages: Belongs to the peptidase M24B family.

710696:INTCA RS05465
gene id: 710696:INTCA_RS05465
uniprot id: E6SDZ4
names: Similarity
messages: Belongs to the CdaR family.

710696:INTCA RS09370
gene id: 710696:INTCA_RS09370
uniprot id: E6SB74
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

710696:INTCA RS02330
gene id: 710696:INTCA_RS02330
uniprot id: E6S8N6
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

710696:INTCA RS06380
gene id: 710696:INTCA_RS06380
uniprot id: E6SFP2
names: Similarity
messages: Belongs to the peptidase S66 family.

710696:INTCA RS04455
gene id: 710696:INTCA_RS04455
uniprot id: E6SC69
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

710696:INTCA RS09950
gene id: 710696:INTCA_RS09950
uniprot id: E6SBW2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

710696:INTCA RS14255
gene id: 710696:INTCA_RS14255
uniprot id: E6SA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

710696:INTCA RS01575
gene id: 710696:INTCA_RS01575
uniprot id: E6S7G7
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

710696:INTCA RS00940
gene id: 710696:INTCA_RS00940
uniprot id: E6S606
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17075
gene id: 710696:INTCA_RS17075
uniprot id: E6SF50
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

710696:INTCA RS15435
gene id: 710696:INTCA_RS15435
uniprot id: E6SC04
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06965
gene id: 710696:INTCA_RS06965
uniprot id: E6S6Z7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

710696:INTCA RS10385
gene id: 710696:INTCA_RS10385
uniprot id: E6SCH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

710696:INTCA RS14740
gene id: 710696:INTCA_RS14740
uniprot id: E6SAU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

710696:INTCA RS12415
gene id: 710696:INTCA_RS12415
uniprot id: E6S6G6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

710696:INTCA RS14945
gene id: 710696:INTCA_RS14945
uniprot id: E6SAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

710696:INTCA RS06085
gene id: 710696:INTCA_RS06085
uniprot id: E6SFI6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS16790
gene id: 710696:INTCA_RS16790
uniprot id: E6SED2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11895
gene id: 710696:INTCA_RS11895
uniprot id: E6SFS2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

710696:INTCA RS07725
gene id: 710696:INTCA_RS07725
uniprot id: E6S8B9
names: Similarity
messages: Belongs to the YggT family.

710696:INTCA RS13230
gene id: 710696:INTCA_RS13230
uniprot id: E6S8F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS05000
gene id: 710696:INTCA_RS05000
uniprot id: E6SCW1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

710696:INTCA RS18340
gene id: 710696:INTCA_RS18340
uniprot id: E6S7F5
names: Similarity
messages: Belongs to the ParB family.

710696:INTCA RS13570
gene id: 710696:INTCA_RS13570
uniprot id: E6S911
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

710696:INTCA RS07860
gene id: 710696:INTCA_RS07860
uniprot id: E6S8E4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

710696:INTCA RS04665
gene id: 710696:INTCA_RS04665
uniprot id: E6SCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

710696:INTCA RS07240
gene id: 710696:INTCA_RS07240
uniprot id: E6S7N8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS08120
gene id: 710696:INTCA_RS08120
uniprot id: E6S8X7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

710696:INTCA RS08165
gene id: 710696:INTCA_RS08165
uniprot id: E6S8Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

710696:INTCA RS04305
gene id: 710696:INTCA_RS04305
uniprot id: E6SBQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

710696:INTCA RS09350
gene id: 710696:INTCA_RS09350
uniprot id: E6SB69
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

710696:INTCA RS12110
gene id: 710696:INTCA_RS12110
uniprot id: E6SFW4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS12580
gene id: 710696:INTCA_RS12580
uniprot id: E6S754
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS02450
gene id: 710696:INTCA_RS02450
uniprot id: E6S8R0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11160
gene id: 710696:INTCA_RS11160
uniprot id: E6SE62
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

710696:INTCA RS01915
gene id: 710696:INTCA_RS01915
uniprot id: E6S820
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS00995
gene id: 710696:INTCA_RS00995
uniprot id: E6S615
names: Similarity
messages: Belongs to the YciI family.

710696:INTCA RS05860
gene id: 710696:INTCA_RS05860
uniprot id: E6SES9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

710696:INTCA RS11495
gene id: 710696:INTCA_RS11495
uniprot id: E6SEY7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS17095
gene id: 710696:INTCA_RS17095
uniprot id: E6SF54
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

710696:INTCA RS16975
gene id: 710696:INTCA_RS16975
uniprot id: E6SEG9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04065
gene id: 710696:INTCA_RS04065
uniprot id: E6SBL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

710696:INTCA RS13090
gene id: 710696:INTCA_RS13090
uniprot id: E6S7Z4
names: Similarity
messages: Belongs to the AlaDH/PNT family.

710696:INTCA RS13465
gene id: 710696:INTCA_RS13465
uniprot id: E6S8K6
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

710696:INTCA RS12230
gene id: 710696:INTCA_RS12230
uniprot id: E6S6C8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS02790
gene id: 710696:INTCA_RS02790
uniprot id: E6S9C1
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

710696:INTCA RS01985
gene id: 710696:INTCA_RS01985
uniprot id: E6S834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

710696:INTCA RS11605
gene id: 710696:INTCA_RS11605
uniprot id: E6SF09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

710696:INTCA RS10770
gene id: 710696:INTCA_RS10770
uniprot id: E6SDI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS11295
gene id: 710696:INTCA_RS11295
uniprot id: E6SE88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

710696:INTCA RS02955
gene id: 710696:INTCA_RS02955
uniprot id: E6S9T9
names: Subcellular Location Annotation
messages: Cell membrane

710696:INTCA RS10460
gene id: 710696:INTCA_RS10460
uniprot id: E6SCY4
names: Similarity
messages: Belongs to the CdaR family.

710696:INTCA RS14245
gene id: 710696:INTCA_RS14245
uniprot id: E6SA71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

710696:INTCA RS08590
gene id: 710696:INTCA_RS08590
uniprot id: E6S9L3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

710696:INTCA RS04445
gene id: 710696:INTCA_RS04445
uniprot id: E6SC67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

710696:INTCA RS11385
gene id: 710696:INTCA_RS11385
uniprot id: E6SEA6
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

710696:INTCA RS05220
gene id: 710696:INTCA_RS05220
uniprot id: E6SDD7
names: Similarity
messages: Belongs to the asparagine synthetase family.

710696:INTCA RS14960
gene id: 710696:INTCA_RS14960
uniprot id: E6SAZ2
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

710696:INTCA RS09230
gene id: 710696:INTCA_RS09230
uniprot id: E6SAR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

710696:INTCA RS03665
gene id: 710696:INTCA_RS03665
uniprot id: E6SB09
names: Similarity
messages: Belongs to the peptidase S1C family.

710696:INTCA RS12070
gene id: 710696:INTCA_RS12070
uniprot id: E6SFV6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS16370
gene id: 710696:INTCA_RS16370
uniprot id: E6SDP6
names: Similarity
messages: Belongs to the GARS family.

710696:INTCA RS11615
gene id: 710696:INTCA_RS11615
uniprot id: E6SF11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

710696:INTCA RS05995
gene id: 710696:INTCA_RS05995
uniprot id: E6SEV6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

710696:INTCA RS12220
gene id: 710696:INTCA_RS12220
uniprot id: E6S6C6
names: Similarity
messages: Belongs to the UPF0045 family.

710696:INTCA RS14205
gene id: 710696:INTCA_RS14205
uniprot id: E6S9S3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

710696:INTCA RS02610
gene id: 710696:INTCA_RS02610
uniprot id: E6S985
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09925
gene id: 710696:INTCA_RS09925
uniprot id: E6SBV7
names: Similarity
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

710696:INTCA RS04550
gene id: 710696:INTCA_RS04550
uniprot id: E6SC88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

710696:INTCA RS03490
gene id: 710696:INTCA_RS03490
uniprot id: E6SAI5
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

710696:INTCA RS05045
gene id: 710696:INTCA_RS05045
uniprot id: E6SCX0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS05690
gene id: 710696:INTCA_RS05690
uniprot id: E6SE39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

710696:INTCA RS10245
gene id: 710696:INTCA_RS10245
uniprot id: E6SCF1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

710696:INTCA RS16630
gene id: 710696:INTCA_RS16630
uniprot id: E6SDU6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

710696:INTCA RS03020
gene id: 710696:INTCA_RS03020
uniprot id: E6S9V2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

710696:INTCA RS14490
gene id: 710696:INTCA_RS14490
uniprot id: E6SAB7
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

710696:INTCA RS14480
gene id: 710696:INTCA_RS14480
uniprot id: E6SAB5
names: Similarity
messages: Belongs to the group II decarboxylase family.

710696:INTCA RS08785
gene id: 710696:INTCA_RS08785
uniprot id: E6SA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS09020
gene id: 710696:INTCA_RS09020
uniprot id: E6SAL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

710696:INTCA RS07800
gene id: 710696:INTCA_RS07800
uniprot id: E6S8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

710696:INTCA RS16290
gene id: 710696:INTCA_RS16290
uniprot id: E6SD93
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

710696:INTCA RS09770
gene id: 710696:INTCA_RS09770
uniprot id: E6SBS6
names: Similarity
messages: Belongs to the leucine-binding protein family.

710696:INTCA RS17840
gene id: 710696:INTCA_RS17840
uniprot id: E6S6J9
names: Similarity
messages: Belongs to the CsoR family.

710696:INTCA RS08775
gene id: 710696:INTCA_RS08775
uniprot id: E6SA36
names: Similarity
messages: Belongs to the band 7/mec-2 family.

710696:INTCA RS03615
gene id: 710696:INTCA_RS03615
uniprot id: E6SAZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS05805
gene id: 710696:INTCA_RS05805
uniprot id: E6SER6
names: Cofactor
messages: Binds 1 FAD per subunit.

710696:INTCA RS03515
gene id: 710696:INTCA_RS03515
uniprot id: E6SAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS12390
gene id: 710696:INTCA_RS12390
uniprot id: E6S6G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS06610
gene id: 710696:INTCA_RS06610
uniprot id: E6S679
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

710696:INTCA RS11260
gene id: 710696:INTCA_RS11260
uniprot id: E6SE82
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08365
gene id: 710696:INTCA_RS08365
uniprot id: E6S9G6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04770
gene id: 710696:INTCA_RS04770
uniprot id: E6SCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS07750
gene id: 710696:INTCA_RS07750
uniprot id: E6S8C3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

710696:INTCA RS11910
gene id: 710696:INTCA_RS11910
uniprot id: E6SFS5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

710696:INTCA RS10865
gene id: 710696:INTCA_RS10865
uniprot id: E6SDK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

710696:INTCA RS03585
gene id: 710696:INTCA_RS03585
uniprot id: E6SAK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

710696:INTCA RS18640
gene id: 710696:INTCA_RS18640
uniprot id: E6S8U8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13750
gene id: 710696:INTCA_RS13750
uniprot id: E6S947
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS06810
gene id: 710696:INTCA_RS06810
uniprot id: E6S6B2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS08090
gene id: 710696:INTCA_RS08090
uniprot id: E6S8X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

710696:INTCA RS04145
gene id: 710696:INTCA_RS04145
uniprot id: E6SBM6
names: Similarity
messages: Belongs to the malate synthase family.

710696:INTCA RS12550
gene id: 710696:INTCA_RS12550
uniprot id: E6S747
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17245
gene id: 710696:INTCA_RS17245
uniprot id: E6SF85
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

710696:INTCA RS03745
gene id: 710696:INTCA_RS03745
uniprot id: E6SB25
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04560
gene id: 710696:INTCA_RS04560
uniprot id: E6SC90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

710696:INTCA RS03105
gene id: 710696:INTCA_RS03105
uniprot id: E6S9W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

710696:INTCA RS03070
gene id: 710696:INTCA_RS03070
uniprot id: E6S9W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS13635
gene id: 710696:INTCA_RS13635
uniprot id: E6S924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS05125
gene id: 710696:INTCA_RS05125
uniprot id: E6SDB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

710696:INTCA RS11705
gene id: 710696:INTCA_RS11705
uniprot id: E6SF29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

710696:INTCA RS07050
gene id: 710696:INTCA_RS07050
uniprot id: E6S714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

710696:INTCA RS04470
gene id: 710696:INTCA_RS04470
uniprot id: E6SC72
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

710696:INTCA RS02595
gene id: 710696:INTCA_RS02595
uniprot id: E6S982
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03430
gene id: 710696:INTCA_RS03430
uniprot id: E6SAH4
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

710696:INTCA RS05930
gene id: 710696:INTCA_RS05930
uniprot id: E6SEU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

710696:INTCA RS16465
gene id: 710696:INTCA_RS16465
uniprot id: E6SDR3
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

710696:INTCA RS14860
gene id: 710696:INTCA_RS14860
uniprot id: E6SAX2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS06075
gene id: 710696:INTCA_RS06075
uniprot id: E6SEX2
names: Similarity
messages: Belongs to the BMP lipoprotein family.

710696:INTCA RS12695
gene id: 710696:INTCA_RS12695
uniprot id: E6S776
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

710696:INTCA RS06630
gene id: 710696:INTCA_RS06630
uniprot id: E6S681
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03700
gene id: 710696:INTCA_RS03700
uniprot id: E6SB16
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

710696:INTCA RS13715
gene id: 710696:INTCA_RS13715
uniprot id: E6S940
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

710696:INTCA RS18155
gene id: 710696:INTCA_RS18155
uniprot id: E6S7B8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS18045
gene id: 710696:INTCA_RS18045
uniprot id: E6S6P3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS07430
gene id: 710696:INTCA_RS07430
uniprot id: E6S7S6
names: Similarity
messages: Belongs to the universal stress protein A family.

710696:INTCA RS06065
gene id: 710696:INTCA_RS06065
uniprot id: E6SEX0
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

710696:INTCA RS00205
gene id: 710696:INTCA_RS00205
uniprot id: E6SEJ9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

710696:INTCA RS11775
gene id: 710696:INTCA_RS11775
uniprot id: E6SF43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

710696:INTCA RS11195
gene id: 710696:INTCA_RS11195
uniprot id: E6SE69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

710696:INTCA RS07030
gene id: 710696:INTCA_RS07030
uniprot id: E6S710
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS17265
gene id: 710696:INTCA_RS17265
uniprot id: E6SF89
names: Similarity
messages: Belongs to the FPG family.

710696:INTCA RS14830
gene id: 710696:INTCA_RS14830
uniprot id: E6SAW6
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

710696:INTCA RS08315
gene id: 710696:INTCA_RS08315
uniprot id: E6S9F7
names: Similarity
messages: Belongs to the TrpC family.

710696:INTCA RS02915
gene id: 710696:INTCA_RS02915
uniprot id: E6S9T1
names: Similarity
messages: Belongs to the AHA1 family.

710696:INTCA RS09860
gene id: 710696:INTCA_RS09860
uniprot id: E6SBU4
names: Similarity
messages: Belongs to the thymidine kinase family.

710696:INTCA RS12850
gene id: 710696:INTCA_RS12850
uniprot id: E6S7A7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

710696:INTCA RS15345
gene id: 710696:INTCA_RS15345
uniprot id: E6SBY7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03625
gene id: 710696:INTCA_RS03625
uniprot id: E6SB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

710696:INTCA RS12125
gene id: 710696:INTCA_RS12125
uniprot id: E6SFW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS11365
gene id: 710696:INTCA_RS11365
uniprot id: E6SEA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

710696:INTCA RS02030
gene id: 710696:INTCA_RS02030
uniprot id: E6S844
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

710696:INTCA RS10955
gene id: 710696:INTCA_RS10955
uniprot id: E6SDL7
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

710696:INTCA RS06625
gene id: 710696:INTCA_RS06625
uniprot id: E6S680
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13820
gene id: 710696:INTCA_RS13820
uniprot id: E6S961
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

710696:INTCA RS17415
gene id: 710696:INTCA_RS17415
uniprot id: E6SFX8
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

710696:INTCA RS04910
gene id: 710696:INTCA_RS04910
uniprot id: E6SCU3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08345
gene id: 710696:INTCA_RS08345
uniprot id: E6S9G3
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

710696:INTCA RS08675
gene id: 710696:INTCA_RS08675
uniprot id: E6SA16
names: Similarity
messages: Belongs to the FemABX family.

710696:INTCA RS05050
gene id: 710696:INTCA_RS05050
uniprot id: E6SCX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

710696:INTCA RS08080
gene id: 710696:INTCA_RS08080
uniprot id: E6S8W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS15440
gene id: 710696:INTCA_RS15440
uniprot id: E6SC05
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

710696:INTCA RS07825
gene id: 710696:INTCA_RS07825
uniprot id: E6S8D7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

710696:INTCA RS10070
gene id: 710696:INTCA_RS10070
uniprot id: E6SCB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

710696:INTCA RS13765
gene id: 710696:INTCA_RS13765
uniprot id: E6S950
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

710696:INTCA RS09655
gene id: 710696:INTCA_RS09655
uniprot id: E6SBC4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS11085
gene id: 710696:INTCA_RS11085
uniprot id: E6SDP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS10450
gene id: 710696:INTCA_RS10450
uniprot id: E6SCY2
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

710696:INTCA RS13870
gene id: 710696:INTCA_RS13870
uniprot id: E6S971
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS14795
gene id: 710696:INTCA_RS14795
uniprot id: E6SAV9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

710696:INTCA RS11170
gene id: 710696:INTCA_RS11170
uniprot id: E6SE64
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

710696:INTCA RS11355
gene id: 710696:INTCA_RS11355
uniprot id: E6SEA0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS14570
gene id: 710696:INTCA_RS14570
uniprot id: E6SAD3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04275
gene id: 710696:INTCA_RS04275
uniprot id: E6SBQ2
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

710696:INTCA RS07805
gene id: 710696:INTCA_RS07805
uniprot id: E6S8D3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

710696:INTCA RS14200
gene id: 710696:INTCA_RS14200
uniprot id: E6S9S2
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

710696:INTCA RS08545
gene id: 710696:INTCA_RS08545
uniprot id: E6S9K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

710696:INTCA RS07845
gene id: 710696:INTCA_RS07845
uniprot id: E6S8E1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

710696:INTCA RS11595
gene id: 710696:INTCA_RS11595
uniprot id: E6SF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

710696:INTCA RS12340
gene id: 710696:INTCA_RS12340
uniprot id: E6S6F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

710696:INTCA RS11200
gene id: 710696:INTCA_RS11200
uniprot id: E6SE70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

710696:INTCA RS09885
gene id: 710696:INTCA_RS09885
uniprot id: E6SBU9
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

710696:INTCA RS16350
gene id: 710696:INTCA_RS16350
uniprot id: E6SDA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

710696:INTCA RS07795
gene id: 710696:INTCA_RS07795
uniprot id: E6S8D1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

710696:INTCA RS13790
gene id: 710696:INTCA_RS13790
uniprot id: E6S955
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

710696:INTCA RS11620
gene id: 710696:INTCA_RS11620
uniprot id: E6SF12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

710696:INTCA RS15385
gene id: 710696:INTCA_RS15385
uniprot id: E6SBZ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

710696:INTCA RS17130
gene id: 710696:INTCA_RS17130
uniprot id: E6SF61
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12485
gene id: 710696:INTCA_RS12485
uniprot id: E6S6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

710696:INTCA RS03505
gene id: 710696:INTCA_RS03505
uniprot id: E6SAI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS18205
gene id: 710696:INTCA_RS18205
uniprot id: E6S7C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

710696:INTCA RS16300
gene id: 710696:INTCA_RS16300
uniprot id: E6SD95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

710696:INTCA RS03825
gene id: 710696:INTCA_RS03825
uniprot id: E6SB41
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

710696:INTCA RS06520
gene id: 710696:INTCA_RS06520
uniprot id: E6S663
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

710696:INTCA RS07465
gene id: 710696:INTCA_RS07465
uniprot id: E6S7T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS03450
gene id: 710696:INTCA_RS03450
uniprot id: E6SAH8
names: Similarity
messages: Belongs to the isochorismate synthase family.

710696:INTCA RS01455
gene id: 710696:INTCA_RS01455
uniprot id: E6S6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS12365
gene id: 710696:INTCA_RS12365
uniprot id: E6S6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

710696:INTCA RS14060
gene id: 710696:INTCA_RS14060
uniprot id: E6S9P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

710696:INTCA RS13060
gene id: 710696:INTCA_RS13060
uniprot id: E6S7Y8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS04535
gene id: 710696:INTCA_RS04535
uniprot id: E6SC85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

710696:INTCA RS04290
gene id: 710696:INTCA_RS04290
uniprot id: E6SBQ4
names: Similarity
messages: Belongs to the YoeB family.

710696:INTCA RS03510
gene id: 710696:INTCA_RS03510
uniprot id: E6SAI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS13785
gene id: 710696:INTCA_RS13785
uniprot id: E6S954
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

710696:INTCA RS05855
gene id: 710696:INTCA_RS05855
uniprot id: E6SES8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

710696:INTCA RS16135
gene id: 710696:INTCA_RS16135
uniprot id: E6SD62
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

710696:INTCA RS11390
gene id: 710696:INTCA_RS11390
uniprot id: E6SEA7
names: Similarity
messages: Belongs to the barstar family.

710696:INTCA RS11740
gene id: 710696:INTCA_RS11740
uniprot id: E6SF36
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

710696:INTCA RS13950
gene id: 710696:INTCA_RS13950
uniprot id: E6S9M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

710696:INTCA RS00310
gene id: 710696:INTCA_RS00310
uniprot id: E6SEM1
names: Similarity
messages: Belongs to the UPF0749 family.

710696:INTCA RS10130
gene id: 710696:INTCA_RS10130
uniprot id: E6SCC8
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

710696:INTCA RS01085
gene id: 710696:INTCA_RS01085
uniprot id: E6S632
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

710696:INTCA RS16125
gene id: 710696:INTCA_RS16125
uniprot id: E6SD60
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

710696:INTCA RS15690
gene id: 710696:INTCA_RS15690
uniprot id: E6SCI7
names: Similarity
messages: Belongs to the peptidase C40 family.

710696:INTCA RS07210
gene id: 710696:INTCA_RS07210
uniprot id: E6S7N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

710696:INTCA RS01315
gene id: 710696:INTCA_RS01315
uniprot id: E6S6S9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

710696:INTCA RS02200
gene id: 710696:INTCA_RS02200
uniprot id: E6S875
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

710696:INTCA RS14340
gene id: 710696:INTCA_RS14340
uniprot id: E6SA90
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS04690
gene id: 710696:INTCA_RS04690
uniprot id: E6SCQ2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

710696:INTCA RS03240
gene id: 710696:INTCA_RS03240
uniprot id: E6S9Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

710696:INTCA RS07000
gene id: 710696:INTCA_RS07000
uniprot id: E6S704
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

710696:INTCA RS17185
gene id: 710696:INTCA_RS17185
uniprot id: E6SF73
names: Similarity
messages: Belongs to the Fur family.

710696:INTCA RS03555
gene id: 710696:INTCA_RS03555
uniprot id: E6SAJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

710696:INTCA RS03400
gene id: 710696:INTCA_RS03400
uniprot id: E6SAG9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS08960
gene id: 710696:INTCA_RS08960
uniprot id: E6SAK8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

710696:INTCA RS12435
gene id: 710696:INTCA_RS12435
uniprot id: E6S6H0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

710696:INTCA RS14765
gene id: 710696:INTCA_RS14765
uniprot id: E6SAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

710696:INTCA RS18130
gene id: 710696:INTCA_RS18130
uniprot id: E6S7B3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

710696:INTCA RS03485
gene id: 710696:INTCA_RS03485
uniprot id: E6SAI4
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

710696:INTCA RS10910
gene id: 710696:INTCA_RS10910
uniprot id: E6SDK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

710696:INTCA RS16495
gene id: 710696:INTCA_RS16495
uniprot id: E6SDR9
names: Similarity
messages: Belongs to the peptidase M24B family.

710696:INTCA RS04120
gene id: 710696:INTCA_RS04120
uniprot id: E6SBM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

710696:INTCA RS07775
gene id: 710696:INTCA_RS07775
uniprot id: E6S8C8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

710696:INTCA RS12830
gene id: 710696:INTCA_RS12830
uniprot id: E6S7A3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11415
gene id: 710696:INTCA_RS11415
uniprot id: E6SEB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS12730
gene id: 710696:INTCA_RS12730
uniprot id: E6S782
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

710696:INTCA RS12925
gene id: 710696:INTCA_RS12925
uniprot id: E6S7W1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: Nucleus
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS00930
gene id: 710696:INTCA_RS00930
uniprot id: E6S604
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS10870
gene id: 710696:INTCA_RS10870
uniprot id: E6SDK1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

710696:INTCA RS05090
gene id: 710696:INTCA_RS05090
uniprot id: E6SDB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

710696:INTCA RS05130
gene id: 710696:INTCA_RS05130
uniprot id: E6SDB9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS12285
gene id: 710696:INTCA_RS12285
uniprot id: E6S6E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

710696:INTCA RS07705
gene id: 710696:INTCA_RS07705
uniprot id: E6S8B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

710696:INTCA RS11155
gene id: 710696:INTCA_RS11155
uniprot id: E6SE61
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

710696:INTCA RS01205
gene id: 710696:INTCA_RS01205
uniprot id: E6S6R0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11925
gene id: 710696:INTCA_RS11925
uniprot id: E6SFS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

710696:INTCA RS03620
gene id: 710696:INTCA_RS03620
uniprot id: E6SB00
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS16655
gene id: 710696:INTCA_RS16655
uniprot id: E6SDV1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

710696:INTCA RS08190
gene id: 710696:INTCA_RS08190
uniprot id: E6S8Z1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

710696:INTCA RS15185
gene id: 710696:INTCA_RS15185
uniprot id: E6SBG7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS05180
gene id: 710696:INTCA_RS05180
uniprot id: E6SDC9
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

710696:INTCA RS07670
gene id: 710696:INTCA_RS07670
uniprot id: E6S8A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

710696:INTCA RS06045
gene id: 710696:INTCA_RS06045
uniprot id: E6SEW6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

710696:INTCA RS01070
gene id: 710696:INTCA_RS01070
uniprot id: E6S629
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

710696:INTCA RS18455
gene id: 710696:INTCA_RS18455
uniprot id: E6S5Y4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS09785
gene id: 710696:INTCA_RS09785
uniprot id: E6SBS9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

710696:INTCA RS05215
gene id: 710696:INTCA_RS05215
uniprot id: E6SDD6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

710696:INTCA RS01250
gene id: 710696:INTCA_RS01250
uniprot id: E6S6R8
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

710696:INTCA RS17430
gene id: 710696:INTCA_RS17430
uniprot id: E6SFY1
names: Similarity
messages: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.

710696:INTCA RS11535
gene id: 710696:INTCA_RS11535
uniprot id: E6SEZ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

710696:INTCA RS00935
gene id: 710696:INTCA_RS00935
uniprot id: E6S605
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

710696:INTCA RS09300
gene id: 710696:INTCA_RS09300
uniprot id: E6SAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

710696:INTCA RS00555
gene id: 710696:INTCA_RS00555
uniprot id: E6SFD1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

710696:INTCA RS07305
gene id: 710696:INTCA_RS07305
uniprot id: E6S7Q0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

710696:INTCA RS13905
gene id: 710696:INTCA_RS13905
uniprot id: E6S9L5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

710696:INTCA RS04925
gene id: 710696:INTCA_RS04925
uniprot id: E6SCU6
names: Similarity
messages: Belongs to the peptidase M13 family.

710696:INTCA RS10835
gene id: 710696:INTCA_RS10835
uniprot id: E6SDJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

710696:INTCA RS09250
gene id: 710696:INTCA_RS09250
uniprot id: E6SAR5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS02845
gene id: 710696:INTCA_RS02845
uniprot id: E6S9D2
names: Similarity
messages: Belongs to the peptidase M4 family.

710696:INTCA RS02360
gene id: 710696:INTCA_RS02360
uniprot id: E6S8P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

710696:INTCA RS15135
gene id: 710696:INTCA_RS15135
uniprot id: E6SBF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

710696:INTCA RS06880
gene id: 710696:INTCA_RS06880
uniprot id: E6S6Y2
names: Similarity
messages: Belongs to the peptidase M1 family.

710696:INTCA RS07420
gene id: 710696:INTCA_RS07420
uniprot id: E6S7S4
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07690
gene id: 710696:INTCA_RS07690
uniprot id: E6S8B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS11275
gene id: 710696:INTCA_RS11275
uniprot id: E6SE85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

710696:INTCA RS14145
gene id: 710696:INTCA_RS14145
uniprot id: E6S9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

710696:INTCA RS05020
gene id: 710696:INTCA_RS05020
uniprot id: E6SCW5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS09485
gene id: 710696:INTCA_RS09485
uniprot id: E6SB96
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17235
gene id: 710696:INTCA_RS17235
uniprot id: E6SF83
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS05265
gene id: 710696:INTCA_RS05265
uniprot id: E6SDE8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

710696:INTCA RS13245
gene id: 710696:INTCA_RS13245
uniprot id: E6S8F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS14430
gene id: 710696:INTCA_RS14430
uniprot id: E6SAA5
names: Similarity
messages: Belongs to the malic enzymes family.

710696:INTCA RS03735
gene id: 710696:INTCA_RS03735
uniprot id: E6SB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

710696:INTCA RS04030
gene id: 710696:INTCA_RS04030
uniprot id: E6SBK3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS17820
gene id: 710696:INTCA_RS17820
uniprot id: E6S6J5
names: Subcellular Location Annotation
messages: Cell membrane

710696:INTCA RS12750
gene id: 710696:INTCA_RS12750
uniprot id: E6S786
names: Similarity
messages: Belongs to the phosphohexose mutase family.

710696:INTCA RS00755
gene id: 710696:INTCA_RS00755
uniprot id: E6SFH2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

710696:INTCA RS08565
gene id: 710696:INTCA_RS08565
uniprot id: E6S9K8
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS08400
gene id: 710696:INTCA_RS08400
uniprot id: E6S9H3
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

710696:INTCA RS11995
gene id: 710696:INTCA_RS11995
uniprot id: E6SFU1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

710696:INTCA RS17500
gene id: 710696:INTCA_RS17500
uniprot id: E6SFZ5
names: Similarity
messages: Belongs to the CsoR family.

710696:INTCA RS14510
gene id: 710696:INTCA_RS14510
uniprot id: E6SAC1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS12740
gene id: 710696:INTCA_RS12740
uniprot id: E6S784
names: Similarity
messages: Belongs to the PGI/PMI family.

710696:INTCA RS07730
gene id: 710696:INTCA_RS07730
uniprot id: E6S8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

710696:INTCA RS17560
gene id: 710696:INTCA_RS17560
uniprot id: E6SG06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS03360
gene id: 710696:INTCA_RS03360
uniprot id: E6SAG2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12310
gene id: 710696:INTCA_RS12310
uniprot id: E6S6E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS06190
gene id: 710696:INTCA_RS06190
uniprot id: E6SFK4
names: Similarity
messages: Belongs to the SufE family.

710696:INTCA RS11955
gene id: 710696:INTCA_RS11955
uniprot id: E6SFT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS15340
gene id: 710696:INTCA_RS15340
uniprot id: E6SBY6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12345
gene id: 710696:INTCA_RS12345
uniprot id: E6S6F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

710696:INTCA RS05505
gene id: 710696:INTCA_RS05505
uniprot id: E6SE02
names: Similarity
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

710696:INTCA RS02215
gene id: 710696:INTCA_RS02215
uniprot id: E6S878
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

710696:INTCA RS06160
gene id: 710696:INTCA_RS06160
uniprot id: E6SFJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

710696:INTCA RS01090
gene id: 710696:INTCA_RS01090
uniprot id: E6S633
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

710696:INTCA RS14115
gene id: 710696:INTCA_RS14115
uniprot id: E6S9Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

710696:INTCA RS11730
gene id: 710696:INTCA_RS11730
uniprot id: E6SF34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

710696:INTCA RS06950
gene id: 710696:INTCA_RS06950
uniprot id: E6S6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

710696:INTCA RS04595
gene id: 710696:INTCA_RS04595
uniprot id: E6SC97
names: Subcellular Location Annotation
messages: Secreted

710696:INTCA RS01335
gene id: 710696:INTCA_RS01335
uniprot id: E6S6T3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

710696:INTCA RS10855
gene id: 710696:INTCA_RS10855
uniprot id: E6SDJ8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS08740
gene id: 710696:INTCA_RS08740
uniprot id: E6SA29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

710696:INTCA RS11755
gene id: 710696:INTCA_RS11755
uniprot id: E6SF39
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

710696:INTCA RS07565
gene id: 710696:INTCA_RS07565
uniprot id: E6S888
names: Similarity
messages: Belongs to the FemABX family.

710696:INTCA RS02470
gene id: 710696:INTCA_RS02470
uniprot id: E6S8R4
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

710696:INTCA RS13695
gene id: 710696:INTCA_RS13695
uniprot id: E6S936
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS05480
gene id: 710696:INTCA_RS05480
uniprot id: E6SDZ7
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS10090
gene id: 710696:INTCA_RS10090
uniprot id: E6SCC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

710696:INTCA RS08725
gene id: 710696:INTCA_RS08725
uniprot id: E6SA26
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

710696:INTCA RS03705
gene id: 710696:INTCA_RS03705
uniprot id: E6SB17
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

710696:INTCA RS01095
gene id: 710696:INTCA_RS01095
uniprot id: E6S634
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

710696:INTCA RS13825
gene id: 710696:INTCA_RS13825
uniprot id: E6S962
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

710696:INTCA RS10235
gene id: 710696:INTCA_RS10235
uniprot id: E6SCE9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

710696:INTCA RS08215
gene id: 710696:INTCA_RS08215
uniprot id: E6S8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

710696:INTCA RS01370
gene id: 710696:INTCA_RS01370
uniprot id: E6S6U0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS05650
gene id: 710696:INTCA_RS05650
uniprot id: E6SE31
names: Similarity
messages: Belongs to the HIBADH-related family.

710696:INTCA RS11335
gene id: 710696:INTCA_RS11335
uniprot id: E6SE96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS17435
gene id: 710696:INTCA_RS17435
uniprot id: E6SFY2
names: Similarity
messages: Belongs to the glycosyl hydrolase.

710696:INTCA RS00635
gene id: 710696:INTCA_RS00635
uniprot id: E6SFE8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

710696:INTCA RS12355
gene id: 710696:INTCA_RS12355
uniprot id: E6S6F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

710696:INTCA RS09110
gene id: 710696:INTCA_RS09110
uniprot id: E6SAN7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08640
gene id: 710696:INTCA_RS08640
uniprot id: E6SA09
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

710696:INTCA RS03830
gene id: 710696:INTCA_RS03830
uniprot id: E6SB42
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS02185
gene id: 710696:INTCA_RS02185
uniprot id: E6S872
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

710696:INTCA RS00660
gene id: 710696:INTCA_RS00660
uniprot id: E6SFF3
names: Similarity
messages: Belongs to the FPG family.

710696:INTCA RS08530
gene id: 710696:INTCA_RS08530
uniprot id: E6S9K1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

710696:INTCA RS13965
gene id: 710696:INTCA_RS13965
uniprot id: E6S9M7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

710696:INTCA RS00020
gene id: 710696:INTCA_RS00020
uniprot id: E6SDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

710696:INTCA RS09395
gene id: 710696:INTCA_RS09395
uniprot id: E6SB79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

710696:INTCA RS17775
gene id: 710696:INTCA_RS17775
uniprot id: E6S6I6
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

710696:INTCA RS11760
gene id: 710696:INTCA_RS11760
uniprot id: E6SF40
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

710696:INTCA RS14780
gene id: 710696:INTCA_RS14780
uniprot id: E6SAV6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS03895
gene id: 710696:INTCA_RS03895
uniprot id: E6SB54
names: Similarity
messages: Belongs to the CobH/CbiC family.

710696:INTCA RS05865
gene id: 710696:INTCA_RS05865
uniprot id: E6SET0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

710696:INTCA RS13865
gene id: 710696:INTCA_RS13865
uniprot id: E6S970
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

710696:INTCA RS08665
gene id: 710696:INTCA_RS08665
uniprot id: E6SA14
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12430
gene id: 710696:INTCA_RS12430
uniprot id: E6S6G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

710696:INTCA RS09550
gene id: 710696:INTCA_RS09550
uniprot id: E6SBA8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS07710
gene id: 710696:INTCA_RS07710
uniprot id: E6S8B6
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

710696:INTCA RS03380
gene id: 710696:INTCA_RS03380
uniprot id: E6SAG6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS02395
gene id: 710696:INTCA_RS02395
uniprot id: E6S8P8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS17745
gene id: 710696:INTCA_RS17745
uniprot id: E6SG43
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS09255
gene id: 710696:INTCA_RS09255
uniprot id: E6SAR6
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

710696:INTCA RS18300
gene id: 710696:INTCA_RS18300
uniprot id: E6S7E8
names: Similarity
messages: Belongs to the thioredoxin family.

710696:INTCA RS01970
gene id: 710696:INTCA_RS01970
uniprot id: E6S831
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS08230
gene id: 710696:INTCA_RS08230
uniprot id: E6S8Z9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

710696:INTCA RS06385
gene id: 710696:INTCA_RS06385
uniprot id: E6SFP3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

710696:INTCA RS07135
gene id: 710696:INTCA_RS07135
uniprot id: E6S731
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

710696:INTCA RS08970
gene id: 710696:INTCA_RS08970
uniprot id: E6SAL0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

710696:INTCA RS00500
gene id: 710696:INTCA_RS00500
uniprot id: E6SFC1
names: Similarity
messages: Belongs to the peptidase S51 family.

710696:INTCA RS16155
gene id: 710696:INTCA_RS16155
uniprot id: E6SD66
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS03330
gene id: 710696:INTCA_RS03330
uniprot id: E6SAF6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

710696:INTCA RS01990
gene id: 710696:INTCA_RS01990
uniprot id: E6S835
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

710696:INTCA RS16545
gene id: 710696:INTCA_RS16545
uniprot id: E6SDS9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

710696:INTCA RS11780
gene id: 710696:INTCA_RS11780
uniprot id: E6SF44
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

710696:INTCA RS14940
gene id: 710696:INTCA_RS14940
uniprot id: E6SAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

710696:INTCA RS16535
gene id: 710696:INTCA_RS16535
uniprot id: E6SDS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

710696:INTCA RS11485
gene id: 710696:INTCA_RS11485
uniprot id: E6SEY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

710696:INTCA RS03610
gene id: 710696:INTCA_RS03610
uniprot id: E6SAZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS03890
gene id: 710696:INTCA_RS03890
uniprot id: E6SB53
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS07890
gene id: 710696:INTCA_RS07890
uniprot id: E6S8F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

710696:INTCA RS03600
gene id: 710696:INTCA_RS03600
uniprot id: E6SAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

710696:INTCA RS13915
gene id: 710696:INTCA_RS13915
uniprot id: E6S9L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

710696:INTCA RS10065
gene id: 710696:INTCA_RS10065
uniprot id: E6SCB5
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

710696:INTCA RS05395
gene id: 710696:INTCA_RS05395
uniprot id: E6SDY1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17750
gene id: 710696:INTCA_RS17750
uniprot id: E6SG44
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

710696:INTCA RS18195
gene id: 710696:INTCA_RS18195
uniprot id: E6S7C6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS13340
gene id: 710696:INTCA_RS13340
uniprot id: E6S8I0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

710696:INTCA RS18190
gene id: 710696:INTCA_RS18190
uniprot id: E6S7C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

710696:INTCA RS09415
gene id: 710696:INTCA_RS09415
uniprot id: E6SB83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

710696:INTCA RS11720
gene id: 710696:INTCA_RS11720
uniprot id: E6SF32
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

710696:INTCA RS00425
gene id: 710696:INTCA_RS00425
uniprot id: E6SEP3
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

710696:INTCA RS08855
gene id: 710696:INTCA_RS08855
uniprot id: E6SA51
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

710696:INTCA RS03445
gene id: 710696:INTCA_RS03445
uniprot id: E6SAH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

710696:INTCA RS17620
gene id: 710696:INTCA_RS17620
uniprot id: E6SG18
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

710696:INTCA RS15890
gene id: 710696:INTCA_RS15890
uniprot id: E6SCM8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07315
gene id: 710696:INTCA_RS07315
uniprot id: E6S7Q3
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

710696:INTCA RS06125
gene id: 710696:INTCA_RS06125
uniprot id: E6SFJ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS10980
gene id: 710696:INTCA_RS10980
uniprot id: E6SDM2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

710696:INTCA RS13650
gene id: 710696:INTCA_RS13650
uniprot id: E6S927
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

710696:INTCA RS01515
gene id: 710696:INTCA_RS01515
uniprot id: E6S6W5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

710696:INTCA RS16740
gene id: 710696:INTCA_RS16740
uniprot id: E6SEC1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS02020
gene id: 710696:INTCA_RS02020
uniprot id: E6S842
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

710696:INTCA RS11575
gene id: 710696:INTCA_RS11575
uniprot id: E6SF03
names: Similarity
messages: Belongs to the UPF0102 family.

710696:INTCA RS02995
gene id: 710696:INTCA_RS02995
uniprot id: E6S9U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

710696:INTCA RS10630
gene id: 710696:INTCA_RS10630
uniprot id: E6SD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS10365
gene id: 710696:INTCA_RS10365
uniprot id: E6SCH5
names: Similarity
messages: Belongs to the TPP enzyme family.

710696:INTCA RS16830
gene id: 710696:INTCA_RS16830
uniprot id: E6SEE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

710696:INTCA RS08195
gene id: 710696:INTCA_RS08195
uniprot id: E6S8Z2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

710696:INTCA RS08605
gene id: 710696:INTCA_RS08605
uniprot id: E6SA02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Membrane

710696:INTCA RS13680
gene id: 710696:INTCA_RS13680
uniprot id: E6S933
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

710696:INTCA RS08130
gene id: 710696:INTCA_RS08130
uniprot id: E6S8X9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

710696:INTCA RS14310
gene id: 710696:INTCA_RS14310
uniprot id: E6SA84
names: Similarity
messages: Belongs to the peptidase S58 family.

710696:INTCA RS18200
gene id: 710696:INTCA_RS18200
uniprot id: E6S7C7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

710696:INTCA RS15215
gene id: 710696:INTCA_RS15215
uniprot id: E6SBH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

710696:INTCA RS11610
gene id: 710696:INTCA_RS11610
uniprot id: E6SF10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

710696:INTCA RS11645
gene id: 710696:INTCA_RS11645
uniprot id: E6SF17
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

710696:INTCA RS18330
gene id: 710696:INTCA_RS18330
uniprot id: E6S7F3
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

710696:INTCA RS18050
gene id: 710696:INTCA_RS18050
uniprot id: E6S6P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

710696:INTCA RS00250
gene id: 710696:INTCA_RS00250
uniprot id: E6SEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

710696:INTCA RS00965
gene id: 710696:INTCA_RS00965
uniprot id: E6S609
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

710696:INTCA RS06445
gene id: 710696:INTCA_RS06445
uniprot id: E6SFQ5
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

710696:INTCA RS05055
gene id: 710696:INTCA_RS05055
uniprot id: E6SCX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS07665
gene id: 710696:INTCA_RS07665
uniprot id: E6S8A7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS00960
gene id: 710696:INTCA_RS00960
uniprot id: E6S608
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

710696:INTCA RS07715
gene id: 710696:INTCA_RS07715
uniprot id: E6S8B7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

710696:INTCA RS00835
gene id: 710696:INTCA_RS00835
uniprot id: E6S5Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

710696:INTCA RS04865
gene id: 710696:INTCA_RS04865
uniprot id: E6SCT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

710696:INTCA RS17400
gene id: 710696:INTCA_RS17400
uniprot id: E6SFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS11070
gene id: 710696:INTCA_RS11070
uniprot id: E6SDN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

710696:INTCA RS11410
gene id: 710696:INTCA_RS11410
uniprot id: E6SEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS07200
gene id: 710696:INTCA_RS07200
uniprot id: E6S7N0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS04240
gene id: 710696:INTCA_RS04240
uniprot id: E6SBP5
names: Caution
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09335
gene id: 710696:INTCA_RS09335
uniprot id: E6SB66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

710696:INTCA RS08540
gene id: 710696:INTCA_RS08540
uniprot id: E6S9K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

710696:INTCA RS14715
gene id: 710696:INTCA_RS14715
uniprot id: E6SAU3
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

710696:INTCA RS03005
gene id: 710696:INTCA_RS03005
uniprot id: E6S9U9
names: Similarity
messages: Belongs to the peptidase S13 family.

710696:INTCA RS05230
gene id: 710696:INTCA_RS05230
uniprot id: E6SDD9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07645
gene id: 710696:INTCA_RS07645
uniprot id: E6S8A4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

710696:INTCA RS18510
gene id: 710696:INTCA_RS18510
uniprot id: E6S984
names: Similarity
messages: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.

710696:INTCA RS06265
gene id: 710696:INTCA_RS06265
uniprot id: E6SFL9
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

710696:INTCA RS02840
gene id: 710696:INTCA_RS02840
uniprot id: E6S9D1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS00885
gene id: 710696:INTCA_RS00885
uniprot id: E6S5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

710696:INTCA RS08965
gene id: 710696:INTCA_RS08965
uniprot id: E6SAK9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

710696:INTCA RS11555
gene id: 710696:INTCA_RS11555
uniprot id: E6SEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

710696:INTCA RS08525
gene id: 710696:INTCA_RS08525
uniprot id: E6S9K0
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

710696:INTCA RS00760
gene id: 710696:INTCA_RS00760
uniprot id: E6SFH3
names: Similarity
messages: Belongs to the CFA/CMAS family.

710696:INTCA RS16665
gene id: 710696:INTCA_RS16665
uniprot id: E6SDV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

710696:INTCA RS02795
gene id: 710696:INTCA_RS02795
uniprot id: E6S9C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

710696:INTCA RS11440
gene id: 710696:INTCA_RS11440
uniprot id: E6SEX6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS13855
gene id: 710696:INTCA_RS13855
uniprot id: E6S968
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

710696:INTCA RS11475
gene id: 710696:INTCA_RS11475
uniprot id: E6SEY3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

710696:INTCA RS12065
gene id: 710696:INTCA_RS12065
uniprot id: E6SFV5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06360
gene id: 710696:INTCA_RS06360
uniprot id: E6SFN8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

710696:INTCA RS02560
gene id: 710696:INTCA_RS02560
uniprot id: E6S8T3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS00915
gene id: 710696:INTCA_RS00915
uniprot id: E6S601
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS12195
gene id: 710696:INTCA_RS12195
uniprot id: E6S6C1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

710696:INTCA RS04225
gene id: 710696:INTCA_RS04225
uniprot id: E6SBP2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS06325
gene id: 710696:INTCA_RS06325
uniprot id: E6SFN1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07905
gene id: 710696:INTCA_RS07905
uniprot id: E6S8T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09700
gene id: 710696:INTCA_RS09700
uniprot id: E6SBR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09750
gene id: 710696:INTCA_RS09750
uniprot id: E6SBS2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS01060
gene id: 710696:INTCA_RS01060
uniprot id: E6S627
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

710696:INTCA RS01125
gene id: 710696:INTCA_RS01125
uniprot id: E6S640
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

710696:INTCA RS10290
gene id: 710696:INTCA_RS10290
uniprot id: E6SCG0
names: Similarity
messages: Belongs to the glutamine synthetase family.

710696:INTCA RS07215
gene id: 710696:INTCA_RS07215
uniprot id: E6S7N3
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

710696:INTCA RS05770
gene id: 710696:INTCA_RS05770
uniprot id: E6SER0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

710696:INTCA RS11640
gene id: 710696:INTCA_RS11640
uniprot id: E6SF16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

710696:INTCA RS09480
gene id: 710696:INTCA_RS09480
uniprot id: E6SB95
names: Similarity
messages: Belongs to the glutathione peroxidase family.

710696:INTCA RS08015
gene id: 710696:INTCA_RS08015
uniprot id: E6S8V6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08615
gene id: 710696:INTCA_RS08615
uniprot id: E6SA04
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

710696:INTCA RS03365
gene id: 710696:INTCA_RS03365
uniprot id: E6SAG3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06510
gene id: 710696:INTCA_RS06510
uniprot id: E6S661
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

710696:INTCA RS10990
gene id: 710696:INTCA_RS10990
uniprot id: E6SDM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS01345
gene id: 710696:INTCA_RS01345
uniprot id: E6S6T5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

710696:INTCA RS16060
gene id: 710696:INTCA_RS16060
uniprot id: E6SD47
names: Similarity
messages: Belongs to the DapA family.

710696:INTCA RS09615
gene id: 710696:INTCA_RS09615
uniprot id: E6SBC0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

710696:INTCA RS09000
gene id: 710696:INTCA_RS09000
uniprot id: E6SAL5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

710696:INTCA RS08510
gene id: 710696:INTCA_RS08510
uniprot id: E6S9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

710696:INTCA RS02145
gene id: 710696:INTCA_RS02145
uniprot id: E6S865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

710696:INTCA RS00225
gene id: 710696:INTCA_RS00225
uniprot id: E6SEK4
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

710696:INTCA RS15495
gene id: 710696:INTCA_RS15495
uniprot id: E6SC14
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

710696:INTCA RS13285
gene id: 710696:INTCA_RS13285
uniprot id: E6S8G7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS16305
gene id: 710696:INTCA_RS16305
uniprot id: E6SD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS11080
gene id: 710696:INTCA_RS11080
uniprot id: E6SDP1
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

710696:INTCA RS05095
gene id: 710696:INTCA_RS05095
uniprot id: E6SDB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

710696:INTCA RS16225
gene id: 710696:INTCA_RS16225
uniprot id: E6SD80
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

710696:INTCA RS13860
gene id: 710696:INTCA_RS13860
uniprot id: E6S969
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

710696:INTCA RS05145
gene id: 710696:INTCA_RS05145
uniprot id: E6SDC2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

710696:INTCA RS03770
gene id: 710696:INTCA_RS03770
uniprot id: E6SB31
names: Similarity
messages: Belongs to the citrate synthase family.

710696:INTCA RS06220
gene id: 710696:INTCA_RS06220
uniprot id: E6SFL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

710696:INTCA RS08990
gene id: 710696:INTCA_RS08990
uniprot id: E6SAL3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

710696:INTCA RS11950
gene id: 710696:INTCA_RS11950
uniprot id: E6SFT3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS17035
gene id: 710696:INTCA_RS17035
uniprot id: E6SEH9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

710696:INTCA RS16170
gene id: 710696:INTCA_RS16170
uniprot id: E6SD69
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04310
gene id: 710696:INTCA_RS04310
uniprot id: E6SBQ8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

710696:INTCA RS15885
gene id: 710696:INTCA_RS15885
uniprot id: E6SCM7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04060
gene id: 710696:INTCA_RS04060
uniprot id: E6SBK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

710696:INTCA RS18070
gene id: 710696:INTCA_RS18070
uniprot id: E6S6P8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS13880
gene id: 710696:INTCA_RS13880
uniprot id: E6S973
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

710696:INTCA RS07900
gene id: 710696:INTCA_RS07900
uniprot id: E6S8T6
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

710696:INTCA RS00010
gene id: 710696:INTCA_RS00010
uniprot id: E6SDW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

710696:INTCA RS03475
gene id: 710696:INTCA_RS03475
uniprot id: E6SAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS10830
gene id: 710696:INTCA_RS10830
uniprot id: E6SDJ3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04975
gene id: 710696:INTCA_RS04975
uniprot id: E6SCV6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS16450
gene id: 710696:INTCA_RS16450
uniprot id: E6SDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

710696:INTCA RS05210
gene id: 710696:INTCA_RS05210
uniprot id: E6SDD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

710696:INTCA RS16000
gene id: 710696:INTCA_RS16000
uniprot id: E6SCP9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12185
gene id: 710696:INTCA_RS12185
uniprot id: E6S6B9
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

710696:INTCA RS10890
gene id: 710696:INTCA_RS10890
uniprot id: E6SDK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

710696:INTCA RS06290
gene id: 710696:INTCA_RS06290
uniprot id: E6SFM4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS08055
gene id: 710696:INTCA_RS08055
uniprot id: E6S8W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

710696:INTCA RS04785
gene id: 710696:INTCA_RS04785
uniprot id: E6SCS0
names: Similarity
messages: Belongs to the DapA family.

710696:INTCA RS02685
gene id: 710696:INTCA_RS02685
uniprot id: E6S9A0
names: Similarity
messages: Belongs to the peptidase S8 family.

710696:INTCA RS04195
gene id: 710696:INTCA_RS04195
uniprot id: E6SBN6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS05460
gene id: 710696:INTCA_RS05460
uniprot id: E6SDZ3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17385
gene id: 710696:INTCA_RS17385
uniprot id: E6SFB2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03500
gene id: 710696:INTCA_RS03500
uniprot id: E6SAI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

710696:INTCA RS11005
gene id: 710696:INTCA_RS11005
uniprot id: E6SDM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

710696:INTCA RS11450
gene id: 710696:INTCA_RS11450
uniprot id: E6SEX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS06890
gene id: 710696:INTCA_RS06890
uniprot id: E6S6Y4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

710696:INTCA RS09405
gene id: 710696:INTCA_RS09405
uniprot id: E6SB81
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

710696:INTCA RS05875
gene id: 710696:INTCA_RS05875
uniprot id: E6SET2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12540
gene id: 710696:INTCA_RS12540
uniprot id: E6S745
names: Function
names: Similarity
messages: Belongs to the LarC family.
messages: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.

710696:INTCA RS04050
gene id: 710696:INTCA_RS04050
uniprot id: E6SBK7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS12940
gene id: 710696:INTCA_RS12940
uniprot id: E6S7W3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

710696:INTCA RS12090
gene id: 710696:INTCA_RS12090
uniprot id: E6SFW0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

710696:INTCA RS11190
gene id: 710696:INTCA_RS11190
uniprot id: E6SE68
names: Similarity
messages: Belongs to the MreC family.

710696:INTCA RS02025
gene id: 710696:INTCA_RS02025
uniprot id: E6S843
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

710696:INTCA RS05840
gene id: 710696:INTCA_RS05840
uniprot id: E6SES5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS13830
gene id: 710696:INTCA_RS13830
uniprot id: E6S963
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS08240
gene id: 710696:INTCA_RS08240
uniprot id: E6S901
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

710696:INTCA RS12055
gene id: 710696:INTCA_RS12055
uniprot id: E6SFV3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

710696:INTCA RS08455
gene id: 710696:INTCA_RS08455
uniprot id: E6S9I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the UPF0157 (GrpB) family.
messages: In the N-terminal section; belongs to the CoaE family.

710696:INTCA RS02135
gene id: 710696:INTCA_RS02135
uniprot id: E6S863
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

710696:INTCA RS07070
gene id: 710696:INTCA_RS07070
uniprot id: E6S718
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

710696:INTCA RS07300
gene id: 710696:INTCA_RS07300
uniprot id: E6S7P9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

710696:INTCA RS08370
gene id: 710696:INTCA_RS08370
uniprot id: E6S9G7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12335
gene id: 710696:INTCA_RS12335
uniprot id: E6S6F0
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

710696:INTCA RS03340
gene id: 710696:INTCA_RS03340
uniprot id: E6SAF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS00305
gene id: 710696:INTCA_RS00305
uniprot id: E6SEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

710696:INTCA RS09135
gene id: 710696:INTCA_RS09135
uniprot id: E6SAP2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

710696:INTCA RS04075
gene id: 710696:INTCA_RS04075
uniprot id: E6SBL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

710696:INTCA RS12795
gene id: 710696:INTCA_RS12795
uniprot id: E6S795
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

710696:INTCA RS02675
gene id: 710696:INTCA_RS02675
uniprot id: E6S998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

710696:INTCA RS09105
gene id: 710696:INTCA_RS09105
uniprot id: E6SAN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

710696:INTCA RS11060
gene id: 710696:INTCA_RS11060
uniprot id: E6SDN7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS08335
gene id: 710696:INTCA_RS08335
uniprot id: E6S9G1
names: Similarity
messages: Belongs to the glutamate synthase family.

710696:INTCA RS19995
gene id: 710696:INTCA_RS19995
uniprot id: E6SBU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

710696:INTCA RS11990
gene id: 710696:INTCA_RS11990
uniprot id: E6SFU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

710696:INTCA RS14180
gene id: 710696:INTCA_RS14180
uniprot id: E6S9R8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Heterodimer of an alpha and a beta chain.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS08170
gene id: 710696:INTCA_RS08170
uniprot id: E6S8Y7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS02775
gene id: 710696:INTCA_RS02775
uniprot id: E6S9B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

710696:INTCA RS00810
gene id: 710696:INTCA_RS00810
uniprot id: E6SFI3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

710696:INTCA RS10985
gene id: 710696:INTCA_RS10985
uniprot id: E6SDM3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

710696:INTCA RS17005
gene id: 710696:INTCA_RS17005
uniprot id: E6SEH3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

710696:INTCA RS02115
gene id: 710696:INTCA_RS02115
uniprot id: E6S859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS02245
gene id: 710696:INTCA_RS02245
uniprot id: E6S8L9
names: Similarity
messages: Belongs to the type IB topoisomerase family.

710696:INTCA RS13025
gene id: 710696:INTCA_RS13025
uniprot id: E6S7Y1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS10455
gene id: 710696:INTCA_RS10455
uniprot id: E6SCY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

710696:INTCA RS10010
gene id: 710696:INTCA_RS10010
uniprot id: E6SBX4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

710696:INTCA RS16485
gene id: 710696:INTCA_RS16485
uniprot id: E6SDR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

710696:INTCA RS11125
gene id: 710696:INTCA_RS11125
uniprot id: E6SE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

710696:INTCA RS08245
gene id: 710696:INTCA_RS08245
uniprot id: E6S902
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

710696:INTCA RS00720
gene id: 710696:INTCA_RS00720
uniprot id: E6SFG5
names: Similarity
names: Subunit
messages: Belongs to the beta-eliminating lyase family.
messages: Homotetramer.

710696:INTCA RS08465
gene id: 710696:INTCA_RS08465
uniprot id: E6S9I8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

710696:INTCA RS07830
gene id: 710696:INTCA_RS07830
uniprot id: E6S8D8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11145
gene id: 710696:INTCA_RS11145
uniprot id: E6SE58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

710696:INTCA RS01850
gene id: 710696:INTCA_RS01850
uniprot id: E6S7L5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06725
gene id: 710696:INTCA_RS06725
uniprot id: E6S698
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

710696:INTCA RS06295
gene id: 710696:INTCA_RS06295
uniprot id: E6SFM5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

710696:INTCA RS09375
gene id: 710696:INTCA_RS09375
uniprot id: E6SB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS03110
gene id: 710696:INTCA_RS03110
uniprot id: E6S9X0
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

710696:INTCA RS18185
gene id: 710696:INTCA_RS18185
uniprot id: E6S7C4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

710696:INTCA RS11590
gene id: 710696:INTCA_RS11590
uniprot id: E6SF06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

710696:INTCA RS07695
gene id: 710696:INTCA_RS07695
uniprot id: E6S8B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

710696:INTCA RS07090
gene id: 710696:INTCA_RS07090
uniprot id: E6S722
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

710696:INTCA RS10405
gene id: 710696:INTCA_RS10405
uniprot id: E6SCX4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

710696:INTCA RS14085
gene id: 710696:INTCA_RS14085
uniprot id: E6S9Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

710696:INTCA RS03000
gene id: 710696:INTCA_RS03000
uniprot id: E6S9U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

710696:INTCA RS18065
gene id: 710696:INTCA_RS18065
uniprot id: E6S6P7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

710696:INTCA RS12060
gene id: 710696:INTCA_RS12060
uniprot id: E6SFV4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

710696:INTCA RS08620
gene id: 710696:INTCA_RS08620
uniprot id: E6SA05
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

710696:INTCA RS12680
gene id: 710696:INTCA_RS12680
uniprot id: E6S773
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

710696:INTCA RS12315
gene id: 710696:INTCA_RS12315
uniprot id: E6S6E6
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

710696:INTCA RS00685
gene id: 710696:INTCA_RS00685
uniprot id: E6SFF8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS12840
gene id: 710696:INTCA_RS12840
uniprot id: E6S7A5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

710696:INTCA RS07745
gene id: 710696:INTCA_RS07745
uniprot id: E6S8C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

710696:INTCA RS08575
gene id: 710696:INTCA_RS08575
uniprot id: E6S9L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

710696:INTCA RS16055
gene id: 710696:INTCA_RS16055
uniprot id: E6SD46
names: Similarity
messages: Belongs to the proline racemase family.

710696:INTCA RS15840
gene id: 710696:INTCA_RS15840
uniprot id: E6SCL8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

710696:INTCA RS12445
gene id: 710696:INTCA_RS12445
uniprot id: E6S6H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

710696:INTCA RS11570
gene id: 710696:INTCA_RS11570
uniprot id: E6SF02
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

710696:INTCA RS10105
gene id: 710696:INTCA_RS10105
uniprot id: E6SCC3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

710696:INTCA RS16285
gene id: 710696:INTCA_RS16285
uniprot id: E6SD92
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

710696:INTCA RS07945
gene id: 710696:INTCA_RS07945
uniprot id: E6S8U2
names: Similarity
messages: Belongs to the TlyA family.

710696:INTCA RS12325
gene id: 710696:INTCA_RS12325
uniprot id: E6S6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

710696:INTCA RS03185
gene id: 710696:INTCA_RS03185
uniprot id: E6S9Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

710696:INTCA RS00750
gene id: 710696:INTCA_RS00750
uniprot id: E6SFH1
names: Similarity
messages: Belongs to the DNA photolyase family.

710696:INTCA RS15250
gene id: 710696:INTCA_RS15250
uniprot id: E6SBI0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS18060
gene id: 710696:INTCA_RS18060
uniprot id: E6S6P6
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

710696:INTCA RS06530
gene id: 710696:INTCA_RS06530
uniprot id: E6S665
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

710696:INTCA RS11030
gene id: 710696:INTCA_RS11030
uniprot id: E6SDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

710696:INTCA RS04645
gene id: 710696:INTCA_RS04645
uniprot id: E6SCA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

710696:INTCA RS04280
gene id: 710696:INTCA_RS04280
uniprot id: E6SBQ3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

710696:INTCA RS00265
gene id: 710696:INTCA_RS00265
uniprot id: E6SEL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

710696:INTCA RS08035
gene id: 710696:INTCA_RS08035
uniprot id: E6S8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS13955
gene id: 710696:INTCA_RS13955
uniprot id: E6S9M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

710696:INTCA RS10050
gene id: 710696:INTCA_RS10050
uniprot id: E6SCB2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS07600
gene id: 710696:INTCA_RS07600
uniprot id: E6S895
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04045
gene id: 710696:INTCA_RS04045
uniprot id: E6SBK6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

710696:INTCA RS01995
gene id: 710696:INTCA_RS01995
uniprot id: E6S836
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

710696:INTCA RS18660
gene id: 710696:INTCA_RS18660
uniprot id: E6SAR0
names: Similarity
messages: Belongs to the UPF0749 family.

710696:INTCA RS11585
gene id: 710696:INTCA_RS11585
uniprot id: E6SF05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

710696:INTCA RS09460
gene id: 710696:INTCA_RS09460
uniprot id: E6SB91
names: Similarity
messages: Belongs to the cytochrome c-552 family.

710696:INTCA RS13775
gene id: 710696:INTCA_RS13775
uniprot id: E6S952
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

710696:INTCA RS09755
gene id: 710696:INTCA_RS09755
uniprot id: E6SBS3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS01130
gene id: 710696:INTCA_RS01130
uniprot id: E6S641
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

710696:INTCA RS16615
gene id: 710696:INTCA_RS16615
uniprot id: E6SDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS17230
gene id: 710696:INTCA_RS17230
uniprot id: E6SF82
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

710696:INTCA RS14515
gene id: 710696:INTCA_RS14515
uniprot id: E6SAC2
names: Similarity
messages: Belongs to the AHA1 family.

710696:INTCA RS17780
gene id: 710696:INTCA_RS17780
uniprot id: E6S6I7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS19990
gene id: 710696:INTCA_RS19990
uniprot id: E6SBU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09090
gene id: 710696:INTCA_RS09090
uniprot id: E6SAN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

710696:INTCA RS10320
gene id: 710696:INTCA_RS10320
uniprot id: E6SCG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

710696:INTCA RS11430
gene id: 710696:INTCA_RS11430
uniprot id: E6SEX4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

710696:INTCA RS12385
gene id: 710696:INTCA_RS12385
uniprot id: E6S6G0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS10480
gene id: 710696:INTCA_RS10480
uniprot id: E6SCY8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

710696:INTCA RS05775
gene id: 710696:INTCA_RS05775
uniprot id: E6SER1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11985
gene id: 710696:INTCA_RS11985
uniprot id: E6SFT9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS16460
gene id: 710696:INTCA_RS16460
uniprot id: E6SDR2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

710696:INTCA RS13180
gene id: 710696:INTCA_RS13180
uniprot id: E6S812
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS12235
gene id: 710696:INTCA_RS12235
uniprot id: E6S6C9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

710696:INTCA RS04520
gene id: 710696:INTCA_RS04520
uniprot id: E6SC82
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

710696:INTCA RS06935
gene id: 710696:INTCA_RS06935
uniprot id: E6S6Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

710696:INTCA RS09220
gene id: 710696:INTCA_RS09220
uniprot id: E6SAQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

710696:INTCA RS16840
gene id: 710696:INTCA_RS16840
uniprot id: E6SEE2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

710696:INTCA RS14895
gene id: 710696:INTCA_RS14895
uniprot id: E6SAX9
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.

710696:INTCA RS13900
gene id: 710696:INTCA_RS13900
uniprot id: E6S977
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

710696:INTCA RS16575
gene id: 710696:INTCA_RS16575
uniprot id: E6SDT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

710696:INTCA RS11345
gene id: 710696:INTCA_RS11345
uniprot id: E6SE98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS14615
gene id: 710696:INTCA_RS14615
uniprot id: E6SAD9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS09380
gene id: 710696:INTCA_RS09380
uniprot id: E6SB76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

710696:INTCA RS09310
gene id: 710696:INTCA_RS09310
uniprot id: E6SAS6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

710696:INTCA RS10260
gene id: 710696:INTCA_RS10260
uniprot id: E6SCF4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

710696:INTCA RS13940
gene id: 710696:INTCA_RS13940
uniprot id: E6S9M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

710696:INTCA RS16980
gene id: 710696:INTCA_RS16980
uniprot id: E6SEH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

710696:INTCA RS10275
gene id: 710696:INTCA_RS10275
uniprot id: E6SCF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

710696:INTCA RS14465
gene id: 710696:INTCA_RS14465
uniprot id: E6SAB2
names: Similarity
messages: Belongs to the peptidase S58 family.

710696:INTCA RS02835
gene id: 710696:INTCA_RS02835
uniprot id: E6S9D0
names: Similarity
messages: Belongs to the DDAH family.

710696:INTCA RS14800
gene id: 710696:INTCA_RS14800
uniprot id: E6SAW0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

710696:INTCA RS10205
gene id: 710696:INTCA_RS10205
uniprot id: E6SCE3
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

710696:INTCA RS12475
gene id: 710696:INTCA_RS12475
uniprot id: E6S6H7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS06685
gene id: 710696:INTCA_RS06685
uniprot id: E6S692
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

710696:INTCA RS14425
gene id: 710696:INTCA_RS14425
uniprot id: E6SAA4
names: Similarity
messages: Belongs to the UPF0234 family.

710696:INTCA RS04295
gene id: 710696:INTCA_RS04295
uniprot id: E6SBQ5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

710696:INTCA RS03565
gene id: 710696:INTCA_RS03565
uniprot id: E6SAK0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS12155
gene id: 710696:INTCA_RS12155
uniprot id: E6SFX3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

710696:INTCA RS06645
gene id: 710696:INTCA_RS06645
uniprot id: E6S684
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

710696:INTCA RS09450
gene id: 710696:INTCA_RS09450
uniprot id: E6SB89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

710696:INTCA RS03260
gene id: 710696:INTCA_RS03260
uniprot id: E6SAE1
names: Similarity
messages: Belongs to the histone deacetylase family.

710696:INTCA RS20005
gene id: 710696:INTCA_RS20005
uniprot id: E6SEM6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07020
gene id: 710696:INTCA_RS07020
uniprot id: E6S708
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

710696:INTCA RS07165
gene id: 710696:INTCA_RS07165
uniprot id: E6S736
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS14440
gene id: 710696:INTCA_RS14440
uniprot id: E6SAA7
names: Similarity
messages: Belongs to the WXG100 family.

710696:INTCA RS10705
gene id: 710696:INTCA_RS10705
uniprot id: E6SD32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS08075
gene id: 710696:INTCA_RS08075
uniprot id: E6S8W8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

710696:INTCA RS08100
gene id: 710696:INTCA_RS08100
uniprot id: E6S8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

710696:INTCA RS15425
gene id: 710696:INTCA_RS15425
uniprot id: E6SC02
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS14700
gene id: 710696:INTCA_RS14700
uniprot id: E6SAU0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

710696:INTCA RS00040
gene id: 710696:INTCA_RS00040
uniprot id: E6SDW7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS16200
gene id: 710696:INTCA_RS16200
uniprot id: E6SD75
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS05895
gene id: 710696:INTCA_RS05895
uniprot id: E6SET6
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

710696:INTCA RS08645
gene id: 710696:INTCA_RS08645
uniprot id: E6SA10
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

710696:INTCA RS10415
gene id: 710696:INTCA_RS10415
uniprot id: E6SCX5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

710696:INTCA RS04245
gene id: 710696:INTCA_RS04245
uniprot id: E6SBP6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

710696:INTCA RS03320
gene id: 710696:INTCA_RS03320
uniprot id: E6SAF4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

710696:INTCA RS07155
gene id: 710696:INTCA_RS07155
uniprot id: E6S734
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS01745
gene id: 710696:INTCA_RS01745
uniprot id: E6S7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS10875
gene id: 710696:INTCA_RS10875
uniprot id: E6SDK2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

710696:INTCA RS04820
gene id: 710696:INTCA_RS04820
uniprot id: E6SCS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

710696:INTCA RS07075
gene id: 710696:INTCA_RS07075
uniprot id: E6S719
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

710696:INTCA RS08880
gene id: 710696:INTCA_RS08880
uniprot id: E6SA56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

710696:INTCA RS00390
gene id: 710696:INTCA_RS00390
uniprot id: E6SEN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS10610
gene id: 710696:INTCA_RS10610
uniprot id: E6SD13
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

710696:INTCA RS19785
gene id: 710696:INTCA_RS19785
uniprot id: E6SCU9
names: Subcellular Location Annotation
messages: Secreted

710696:INTCA RS08470
gene id: 710696:INTCA_RS08470
uniprot id: E6S9I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

710696:INTCA RS13615
gene id: 710696:INTCA_RS13615
uniprot id: E6S920
names: Similarity
messages: Belongs to the FBPase class 2 family.

710696:INTCA RS02555
gene id: 710696:INTCA_RS02555
uniprot id: E6S8T2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08235
gene id: 710696:INTCA_RS08235
uniprot id: E6S900
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

710696:INTCA RS11035
gene id: 710696:INTCA_RS11035
uniprot id: E6SDN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

710696:INTCA RS09385
gene id: 710696:INTCA_RS09385
uniprot id: E6SB77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

710696:INTCA RS13200
gene id: 710696:INTCA_RS13200
uniprot id: E6S816
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS00295
gene id: 710696:INTCA_RS00295
uniprot id: E6SEL8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

710696:INTCA RS08125
gene id: 710696:INTCA_RS08125
uniprot id: E6S8X8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

710696:INTCA RS16855
gene id: 710696:INTCA_RS16855
uniprot id: E6SEE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

710696:INTCA RS16810
gene id: 710696:INTCA_RS16810
uniprot id: E6SED6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

710696:INTCA RS13580
gene id: 710696:INTCA_RS13580
uniprot id: E6S913
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

710696:INTCA RS12825
gene id: 710696:INTCA_RS12825
uniprot id: E6S7A2
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

710696:INTCA RS01920
gene id: 710696:INTCA_RS01920
uniprot id: E6S821
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

710696:INTCA RS12875
gene id: 710696:INTCA_RS12875
uniprot id: E6S7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

710696:INTCA RS01940
gene id: 710696:INTCA_RS01940
uniprot id: E6S825
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS05075
gene id: 710696:INTCA_RS05075
uniprot id: E6SDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

710696:INTCA RS02810
gene id: 710696:INTCA_RS02810
uniprot id: E6S9C5
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

710696:INTCA RS13840
gene id: 710696:INTCA_RS13840
uniprot id: E6S965
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

710696:INTCA RS01245
gene id: 710696:INTCA_RS01245
uniprot id: E6S6R7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS09840
gene id: 710696:INTCA_RS09840
uniprot id: E6SBU0
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

710696:INTCA RS18250
gene id: 710696:INTCA_RS18250
uniprot id: E6S7D7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS16965
gene id: 710696:INTCA_RS16965
uniprot id: E6SEG7
names: Function
names: Similarity
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

710696:INTCA RS10110
gene id: 710696:INTCA_RS10110
uniprot id: E6SCC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

710696:INTCA RS04640
gene id: 710696:INTCA_RS04640
uniprot id: E6SCA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

710696:INTCA RS02455
gene id: 710696:INTCA_RS02455
uniprot id: E6S8R1
names: Similarity
messages: Belongs to the universal stress protein A family.

710696:INTCA RS03645
gene id: 710696:INTCA_RS03645
uniprot id: E6SB05
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

710696:INTCA RS07680
gene id: 710696:INTCA_RS07680
uniprot id: E6S8B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

710696:INTCA RS18370
gene id: 710696:INTCA_RS18370
uniprot id: E6S7F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

710696:INTCA RS16650
gene id: 710696:INTCA_RS16650
uniprot id: E6SDV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

710696:INTCA RS10540
gene id: 710696:INTCA_RS10540
uniprot id: E6SCZ8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

710696:INTCA RS11600
gene id: 710696:INTCA_RS11600
uniprot id: E6SF08
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

710696:INTCA RS10825
gene id: 710696:INTCA_RS10825
uniprot id: E6SDJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS09055
gene id: 710696:INTCA_RS09055
uniprot id: E6SAM6
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

710696:INTCA RS04955
gene id: 710696:INTCA_RS04955
uniprot id: E6SCV2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

710696:INTCA RS00235
gene id: 710696:INTCA_RS00235
uniprot id: E6SEK6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04915
gene id: 710696:INTCA_RS04915
uniprot id: E6SCU4
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS01855
gene id: 710696:INTCA_RS01855
uniprot id: E6S7L6
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07875
gene id: 710696:INTCA_RS07875
uniprot id: E6S8E7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

710696:INTCA RS13335
gene id: 710696:INTCA_RS13335
uniprot id: E6S8H9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

710696:INTCA RS12105
gene id: 710696:INTCA_RS12105
uniprot id: E6SFW3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS06465
gene id: 710696:INTCA_RS06465
uniprot id: E6S653
names: Similarity
messages: Belongs to the GSP E family.

710696:INTCA RS11830
gene id: 710696:INTCA_RS11830
uniprot id: E6SFR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
messages: Homodimer.

710696:INTCA RS08070
gene id: 710696:INTCA_RS08070
uniprot id: E6S8W7
names: Similarity
messages: Belongs to the peptidase A24 family.

710696:INTCA RS14920
gene id: 710696:INTCA_RS14920
uniprot id: E6SAY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Monomer.

710696:INTCA RS12490
gene id: 710696:INTCA_RS12490
uniprot id: E6S6I0
names: Similarity
messages: Belongs to the FGGY kinase family.

710696:INTCA RS17805
gene id: 710696:INTCA_RS17805
uniprot id: E6S6J2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS06140
gene id: 710696:INTCA_RS06140
uniprot id: E6SFJ4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

710696:INTCA RS03415
gene id: 710696:INTCA_RS03415
uniprot id: E6SAH1
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS14605
gene id: 710696:INTCA_RS14605
uniprot id: E6SAD7
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

710696:INTCA RS12180
gene id: 710696:INTCA_RS12180
uniprot id: E6S6B8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

710696:INTCA RS18175
gene id: 710696:INTCA_RS18175
uniprot id: E6S7C2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

710696:INTCA RS01220
gene id: 710696:INTCA_RS01220
uniprot id: E6S6R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

710696:INTCA RS16775
gene id: 710696:INTCA_RS16775
uniprot id: E6SEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

710696:INTCA RS14290
gene id: 710696:INTCA_RS14290
uniprot id: E6SA80
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07950
gene id: 710696:INTCA_RS07950
uniprot id: E6S8U3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS10815
gene id: 710696:INTCA_RS10815
uniprot id: E6SDJ0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS04525
gene id: 710696:INTCA_RS04525
uniprot id: E6SC84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS11810
gene id: 710696:INTCA_RS11810
uniprot id: E6SFR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

710696:INTCA RS07060
gene id: 710696:INTCA_RS07060
uniprot id: E6S716
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

710696:INTCA RS06785
gene id: 710696:INTCA_RS06785
uniprot id: E6S6A7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS07865
gene id: 710696:INTCA_RS07865
uniprot id: E6S8E5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

710696:INTCA RS16510
gene id: 710696:INTCA_RS16510
uniprot id: E6SDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS15055
gene id: 710696:INTCA_RS15055
uniprot id: E6SBE3
names: Similarity
messages: Belongs to the YoeB family.

710696:INTCA RS03375
gene id: 710696:INTCA_RS03375
uniprot id: E6SAG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

710696:INTCA RS03135
gene id: 710696:INTCA_RS03135
uniprot id: E6S9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS04200
gene id: 710696:INTCA_RS04200
uniprot id: E6SBN7
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17010
gene id: 710696:INTCA_RS17010
uniprot id: E6SEH4
names: Similarity
messages: Belongs to the Fur family.

710696:INTCA RS09195
gene id: 710696:INTCA_RS09195
uniprot id: E6SAQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

710696:INTCA RS02765
gene id: 710696:INTCA_RS02765
uniprot id: E6S9B6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

710696:INTCA RS03310
gene id: 710696:INTCA_RS03310
uniprot id: E6SAF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

710696:INTCA RS10310
gene id: 710696:INTCA_RS10310
uniprot id: E6SCG4
names: Similarity
messages: Belongs to the glutamine synthetase family.

710696:INTCA RS14445
gene id: 710696:INTCA_RS14445
uniprot id: E6SAA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

710696:INTCA RS01955
gene id: 710696:INTCA_RS01955
uniprot id: E6S828
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11330
gene id: 710696:INTCA_RS11330
uniprot id: E6SE95
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS15865
gene id: 710696:INTCA_RS15865
uniprot id: E6SCM3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

710696:INTCA RS10190
gene id: 710696:INTCA_RS10190
uniprot id: E6SCE0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS05110
gene id: 710696:INTCA_RS05110
uniprot id: E6SDB5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

710696:INTCA RS01845
gene id: 710696:INTCA_RS01845
uniprot id: E6S7L4
names: Similarity
messages: Belongs to the leucine-binding protein family.

710696:INTCA RS03035
gene id: 710696:INTCA_RS03035
uniprot id: E6S9V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

710696:INTCA RS12500
gene id: 710696:INTCA_RS12500
uniprot id: E6S6I2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

710696:INTCA RS11215
gene id: 710696:INTCA_RS11215
uniprot id: E6SE73
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

710696:INTCA RS17205
gene id: 710696:INTCA_RS17205
uniprot id: E6SF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

710696:INTCA RS03855
gene id: 710696:INTCA_RS03855
uniprot id: E6SB46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

710696:INTCA RS19490
gene id: 710696:INTCA_RS19490
uniprot id: E6SFP6
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

710696:INTCA RS16530
gene id: 710696:INTCA_RS16530
uniprot id: E6SDS6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS05360
gene id: 710696:INTCA_RS05360
uniprot id: E6SDG7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS01570
gene id: 710696:INTCA_RS01570
uniprot id: E6S7G6
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS16395
gene id: 710696:INTCA_RS16395
uniprot id: E6SDQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

710696:INTCA RS04505
gene id: 710696:INTCA_RS04505
uniprot id: E6SC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

710696:INTCA RS04660
gene id: 710696:INTCA_RS04660
uniprot id: E6SCA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

710696:INTCA RS12130
gene id: 710696:INTCA_RS12130
uniprot id: E6SFW8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

710696:INTCA RS19495
gene id: 710696:INTCA_RS19495
uniprot id: E6SFP7
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

710696:INTCA RS08175
gene id: 710696:INTCA_RS08175
uniprot id: E6S8Y8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

710696:INTCA RS11815
gene id: 710696:INTCA_RS11815
uniprot id: E6SFR1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

710696:INTCA RS08700
gene id: 710696:INTCA_RS08700
uniprot id: E6SA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

710696:INTCA RS17105
gene id: 710696:INTCA_RS17105
uniprot id: E6SF56
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13910
gene id: 710696:INTCA_RS13910
uniprot id: E6S9L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

710696:INTCA RS04680
gene id: 710696:INTCA_RS04680
uniprot id: E6SCQ0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

710696:INTCA RS10725
gene id: 710696:INTCA_RS10725
uniprot id: E6SD35
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

710696:INTCA RS11625
gene id: 710696:INTCA_RS11625
uniprot id: E6SF13
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

710696:INTCA RS08160
gene id: 710696:INTCA_RS08160
uniprot id: E6S8Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

710696:INTCA RS15450
gene id: 710696:INTCA_RS15450
uniprot id: E6SC07
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

710696:INTCA RS05365
gene id: 710696:INTCA_RS05365
uniprot id: E6SDG8
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

710696:INTCA RS08705
gene id: 710696:INTCA_RS08705
uniprot id: E6SA22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

710696:INTCA RS17115
gene id: 710696:INTCA_RS17115
uniprot id: E6SF58
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS03045
gene id: 710696:INTCA_RS03045
uniprot id: E6S9V7
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

710696:INTCA RS10810
gene id: 710696:INTCA_RS10810
uniprot id: E6SDI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

710696:INTCA RS18090
gene id: 710696:INTCA_RS18090
uniprot id: E6S6Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

710696:INTCA RS01280
gene id: 710696:INTCA_RS01280
uniprot id: E6S6S2
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS02160
gene id: 710696:INTCA_RS02160
uniprot id: E6S867
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07275
gene id: 710696:INTCA_RS07275
uniprot id: E6S7P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

710696:INTCA RS09775
gene id: 710696:INTCA_RS09775
uniprot id: E6SBS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

710696:INTCA RS11930
gene id: 710696:INTCA_RS11930
uniprot id: E6SFS9
names: Similarity
messages: Belongs to the glutamine synthetase family.

710696:INTCA RS16045
gene id: 710696:INTCA_RS16045
uniprot id: E6SD44
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS10780
gene id: 710696:INTCA_RS10780
uniprot id: E6SDI3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

710696:INTCA RS13205
gene id: 710696:INTCA_RS13205
uniprot id: E6S8F1
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

710696:INTCA RS08320
gene id: 710696:INTCA_RS08320
uniprot id: E6S9F8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

710696:INTCA RS05150
gene id: 710696:INTCA_RS05150
uniprot id: E6SDC3
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

710696:INTCA RS17170
gene id: 710696:INTCA_RS17170
uniprot id: E6SF69
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

710696:INTCA RS11400
gene id: 710696:INTCA_RS11400
uniprot id: E6SEA9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

710696:INTCA RS08535
gene id: 710696:INTCA_RS08535
uniprot id: E6S9K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS05845
gene id: 710696:INTCA_RS05845
uniprot id: E6SES6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS05940
gene id: 710696:INTCA_RS05940
uniprot id: E6SEU5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS18335
gene id: 710696:INTCA_RS18335
uniprot id: E6S7F4
names: Similarity
messages: Belongs to the FPG family.

710696:INTCA RS05375
gene id: 710696:INTCA_RS05375
uniprot id: E6SDH0
names: Similarity
messages: Belongs to the carbamate kinase family.

710696:INTCA RS10085
gene id: 710696:INTCA_RS10085
uniprot id: E6SCB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

710696:INTCA RS12440
gene id: 710696:INTCA_RS12440
uniprot id: E6S6H1
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

710696:INTCA RS11320
gene id: 710696:INTCA_RS11320
uniprot id: E6SE93
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

710696:INTCA RS11225
gene id: 710696:INTCA_RS11225
uniprot id: E6SE75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

710696:INTCA RS11710
gene id: 710696:INTCA_RS11710
uniprot id: E6SF30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

710696:INTCA RS02000
gene id: 710696:INTCA_RS02000
uniprot id: E6S837
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

710696:INTCA RS10285
gene id: 710696:INTCA_RS10285
uniprot id: E6SCF9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS03025
gene id: 710696:INTCA_RS03025
uniprot id: E6S9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

710696:INTCA RS08060
gene id: 710696:INTCA_RS08060
uniprot id: E6S8W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

710696:INTCA RS02695
gene id: 710696:INTCA_RS02695
uniprot id: E6S9A2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

710696:INTCA RS01945
gene id: 710696:INTCA_RS01945
uniprot id: E6S826
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS12545
gene id: 710696:INTCA_RS12545
uniprot id: E6S746
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS18100
gene id: 710696:INTCA_RS18100
uniprot id: E6S7A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

710696:INTCA RS09715
gene id: 710696:INTCA_RS09715
uniprot id: E6SBR5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS13675
gene id: 710696:INTCA_RS13675
uniprot id: E6S932
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

710696:INTCA RS16025
gene id: 710696:INTCA_RS16025
uniprot id: E6SD40
names: Similarity
messages: Belongs to the proline racemase family.

710696:INTCA RS01750
gene id: 710696:INTCA_RS01750
uniprot id: E6S7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS17530
gene id: 710696:INTCA_RS17530
uniprot id: E6SG00
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

710696:INTCA RS01115
gene id: 710696:INTCA_RS01115
uniprot id: E6S638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

710696:INTCA RS08570
gene id: 710696:INTCA_RS08570
uniprot id: E6S9K9
names: Similarity
messages: Belongs to the GPI family.

710696:INTCA RS16845
gene id: 710696:INTCA_RS16845
uniprot id: E6SEE3
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04070
gene id: 710696:INTCA_RS04070
uniprot id: E6SBL1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS08200
gene id: 710696:INTCA_RS08200
uniprot id: E6S8Z3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

710696:INTCA RS12270
gene id: 710696:INTCA_RS12270
uniprot id: E6S6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

710696:INTCA RS16355
gene id: 710696:INTCA_RS16355
uniprot id: E6SDP3
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

710696:INTCA RS04670
gene id: 710696:INTCA_RS04670
uniprot id: E6SCA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

710696:INTCA RS10785
gene id: 710696:INTCA_RS10785
uniprot id: E6SDI4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

710696:INTCA RS01885
gene id: 710696:INTCA_RS01885
uniprot id: E6S7M2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

710696:INTCA RS05345
gene id: 710696:INTCA_RS05345
uniprot id: E6SDG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

710696:INTCA RS02985
gene id: 710696:INTCA_RS02985
uniprot id: E6S9U5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS17210
gene id: 710696:INTCA_RS17210
uniprot id: E6SF78
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11520
gene id: 710696:INTCA_RS11520
uniprot id: E6SEZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

710696:INTCA RS03480
gene id: 710696:INTCA_RS03480
uniprot id: E6SAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS06550
gene id: 710696:INTCA_RS06550
uniprot id: E6S667
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

710696:INTCA RS18270
gene id: 710696:INTCA_RS18270
uniprot id: E6S7E2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

710696:INTCA RS04235
gene id: 710696:INTCA_RS04235
uniprot id: E6SBP4
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS10210
gene id: 710696:INTCA_RS10210
uniprot id: E6SCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

710696:INTCA RS07425
gene id: 710696:INTCA_RS07425
uniprot id: E6S7S5
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

710696:INTCA RS02120
gene id: 710696:INTCA_RS02120
uniprot id: E6S860
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

710696:INTCA RS14070
gene id: 710696:INTCA_RS14070
uniprot id: E6S9P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

710696:INTCA RS11075
gene id: 710696:INTCA_RS11075
uniprot id: E6SDP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

710696:INTCA RS09575
gene id: 710696:INTCA_RS09575
uniprot id: E6SBB3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS08325
gene id: 710696:INTCA_RS08325
uniprot id: E6S9F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

710696:INTCA RS08630
gene id: 710696:INTCA_RS08630
uniprot id: E6SA07
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

710696:INTCA RS14080
gene id: 710696:INTCA_RS14080
uniprot id: E6S9Q1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

710696:INTCA RS04020
gene id: 710696:INTCA_RS04020
uniprot id: E6SBK1
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

710696:INTCA RS05550
gene id: 710696:INTCA_RS05550
uniprot id: E6SE11
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

710696:INTCA RS12350
gene id: 710696:INTCA_RS12350
uniprot id: E6S6F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

710696:INTCA RS07810
gene id: 710696:INTCA_RS07810
uniprot id: E6S8D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

710696:INTCA RS17920
gene id: 710696:INTCA_RS17920
uniprot id: E6S6L7
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

710696:INTCA RS01035
gene id: 710696:INTCA_RS01035
uniprot id: E6S623
names: Similarity
messages: Belongs to the CsoR family.

710696:INTCA RS11270
gene id: 710696:INTCA_RS11270
uniprot id: E6SE84
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

710696:INTCA RS08905
gene id: 710696:INTCA_RS08905
uniprot id: E6SA60
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS13895
gene id: 710696:INTCA_RS13895
uniprot id: E6S976
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

710696:INTCA RS04115
gene id: 710696:INTCA_RS04115
uniprot id: E6SBM0
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS05025
gene id: 710696:INTCA_RS05025
uniprot id: E6SCW6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS06420
gene id: 710696:INTCA_RS06420
uniprot id: E6SFQ0
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

710696:INTCA RS16720
gene id: 710696:INTCA_RS16720
uniprot id: E6SEB7
names: Similarity
messages: Belongs to the ComB family.

710696:INTCA RS01580
gene id: 710696:INTCA_RS01580
uniprot id: E6S7G8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

710696:INTCA RS18025
gene id: 710696:INTCA_RS18025
uniprot id: E6S6N9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

710696:INTCA RS11140
gene id: 710696:INTCA_RS11140
uniprot id: E6SE57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

710696:INTCA RS02480
gene id: 710696:INTCA_RS02480
uniprot id: E6S8R6
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS02380
gene id: 710696:INTCA_RS02380
uniprot id: E6S8P5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

710696:INTCA RS08555
gene id: 710696:INTCA_RS08555
uniprot id: E6S9K6
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

710696:INTCA RS07755
gene id: 710696:INTCA_RS07755
uniprot id: E6S8C4
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS01735
gene id: 710696:INTCA_RS01735
uniprot id: E6S7J3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

710696:INTCA RS14040
gene id: 710696:INTCA_RS14040
uniprot id: E6S9P3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

710696:INTCA RS09290
gene id: 710696:INTCA_RS09290
uniprot id: E6SAS2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

710696:INTCA RS02725
gene id: 710696:INTCA_RS02725
uniprot id: E6S9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

710696:INTCA RS03535
gene id: 710696:INTCA_RS03535
uniprot id: E6SAJ4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

710696:INTCA RS13770
gene id: 710696:INTCA_RS13770
uniprot id: E6S951
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

710696:INTCA RS14840
gene id: 710696:INTCA_RS14840
uniprot id: E6SAW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

710696:INTCA RS16635
gene id: 710696:INTCA_RS16635
uniprot id: E6SDU7
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

710696:INTCA RS14495
gene id: 710696:INTCA_RS14495
uniprot id: E6SAB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

710696:INTCA RS08150
gene id: 710696:INTCA_RS08150
uniprot id: E6S8Y3
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

710696:INTCA RS00015
gene id: 710696:INTCA_RS00015
uniprot id: E6SDW2
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

710696:INTCA RS02665
gene id: 710696:INTCA_RS02665
uniprot id: E6S996
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

710696:INTCA RS13945
gene id: 710696:INTCA_RS13945
uniprot id: E6S9M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

710696:INTCA RS13930
gene id: 710696:INTCA_RS13930
uniprot id: E6S9M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

710696:INTCA RS10475
gene id: 710696:INTCA_RS10475
uniprot id: E6SCY7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

710696:INTCA RS18380
gene id: 710696:INTCA_RS18380
uniprot id: E6S7G2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

710696:INTCA RS08005
gene id: 710696:INTCA_RS08005
uniprot id: E6S8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS01925
gene id: 710696:INTCA_RS01925
uniprot id: E6S822
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

710696:INTCA RS07685
gene id: 710696:INTCA_RS07685
uniprot id: E6S8B1
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS04810
gene id: 710696:INTCA_RS04810
uniprot id: E6SCS5
names: Similarity
messages: Belongs to the IMPACT family.

710696:INTCA RS02300
gene id: 710696:INTCA_RS02300
uniprot id: E6S8N0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

710696:INTCA RS06440
gene id: 710696:INTCA_RS06440
uniprot id: E6SFQ4
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS13850
gene id: 710696:INTCA_RS13850
uniprot id: E6S967
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

710696:INTCA RS04110
gene id: 710696:INTCA_RS04110
uniprot id: E6SBL9
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS00800
gene id: 710696:INTCA_RS00800
uniprot id: E6SFI1
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

710696:INTCA RS14055
gene id: 710696:INTCA_RS14055
uniprot id: E6S9P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

710696:INTCA RS04795
gene id: 710696:INTCA_RS04795
uniprot id: E6SCS2
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

710696:INTCA RS13595
gene id: 710696:INTCA_RS13595
uniprot id: E6S916
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

710696:INTCA RS17915
gene id: 710696:INTCA_RS17915
uniprot id: E6S6L6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: Nucleus
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS03560
gene id: 710696:INTCA_RS03560
uniprot id: E6SAJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

710696:INTCA RS04210
gene id: 710696:INTCA_RS04210
uniprot id: E6SBN9
names: Similarity
messages: Belongs to the cytochrome P450 family.

710696:INTCA RS00630
gene id: 710696:INTCA_RS00630
uniprot id: E6SFE7
names: Similarity
messages: Belongs to the YciI family.

710696:INTCA RS16610
gene id: 710696:INTCA_RS16610
uniprot id: E6SDU2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

710696:INTCA RS11530
gene id: 710696:INTCA_RS11530
uniprot id: E6SEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

710696:INTCA RS13875
gene id: 710696:INTCA_RS13875
uniprot id: E6S972
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

710696:INTCA RS17540
gene id: 710696:INTCA_RS17540
uniprot id: E6SG02
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS14395
gene id: 710696:INTCA_RS14395
uniprot id: E6SAA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

710696:INTCA RS17030
gene id: 710696:INTCA_RS17030
uniprot id: E6SEH8
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS07675
gene id: 710696:INTCA_RS07675
uniprot id: E6S8A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

710696:INTCA RS14550
gene id: 710696:INTCA_RS14550
uniprot id: E6SAC9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

710696:INTCA RS14720
gene id: 710696:INTCA_RS14720
uniprot id: E6SAU4
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

710696:INTCA RS12140
gene id: 710696:INTCA_RS12140
uniprot id: E6SFX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

710696:INTCA RS03810
gene id: 710696:INTCA_RS03810
uniprot id: E6SB38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

710696:INTCA RS12635
gene id: 710696:INTCA_RS12635
uniprot id: E6S764
names: Similarity
messages: Belongs to the long-chain O-acyltransferase family.

710696:INTCA RS14165
gene id: 710696:INTCA_RS14165
uniprot id: E6S9R5
names: Subcellular Location Annotation
messages: Membrane

710696:INTCA RS11665
gene id: 710696:INTCA_RS11665
uniprot id: E6SF21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

710696:INTCA RS01440
gene id: 710696:INTCA_RS01440
uniprot id: E6S6V0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

710696:INTCA RS16525
gene id: 710696:INTCA_RS16525
uniprot id: E6SDS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

710696:INTCA RS12965
gene id: 710696:INTCA_RS12965
uniprot id: E6S7W8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

710696:INTCA RS10485
gene id: 710696:INTCA_RS10485
uniprot id: E6SCY9
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

710696:INTCA RS05135
gene id: 710696:INTCA_RS05135
uniprot id: E6SDC0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS13835
gene id: 710696:INTCA_RS13835
uniprot id: E6S964
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

710696:INTCA RS07025
gene id: 710696:INTCA_RS07025
uniprot id: E6S709
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

710696:INTCA RS03455
gene id: 710696:INTCA_RS03455
uniprot id: E6SAH9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

710696:INTCA RS03465
gene id: 710696:INTCA_RS03465
uniprot id: E6SAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

710696:INTCA RS13425
gene id: 710696:INTCA_RS13425
uniprot id: E6S8J8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

710696:INTCA RS10150
gene id: 710696:INTCA_RS10150
uniprot id: E6SCD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

710696:INTCA RS16365
gene id: 710696:INTCA_RS16365
uniprot id: E6SDP5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

710696:INTCA RS03550
gene id: 710696:INTCA_RS03550
uniprot id: E6SAJ7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

710696:INTCA RS13385
gene id: 710696:INTCA_RS13385
uniprot id: E6S8I9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

710696:INTCA RS14625
gene id: 710696:INTCA_RS14625
uniprot id: E6SAS8
names: Subcellular Location Annotation
messages: Cytoplasm

710696:INTCA RS12775
gene id: 710696:INTCA_RS12775
uniprot id: E6S791
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

710696:INTCA RS07790
gene id: 710696:INTCA_RS07790
uniprot id: E6S8D0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

710696:INTCA RS15445
gene id: 710696:INTCA_RS15445
uniprot id: E6SC06
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

710696:INTCA RS10145
gene id: 710696:INTCA_RS10145
uniprot id: E6SCD1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.