694429:PYRFU RS08270
gene id: 694429:PYRFU_RS08270
uniprot id: G0ECG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

694429:PYRFU RS07910
gene id: 694429:PYRFU_RS07910
uniprot id: G0EC98
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS01460
gene id: 694429:PYRFU_RS01460
uniprot id: G0EFB0
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04610
gene id: 694429:PYRFU_RS04610
uniprot id: G0EEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

694429:PYRFU RS00020
gene id: 694429:PYRFU_RS00020
uniprot id: G0EDN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

694429:PYRFU RS00220
gene id: 694429:PYRFU_RS00220
uniprot id: G0EE00
names: Similarity
messages: Belongs to the UPF0201 family.

694429:PYRFU RS08555
gene id: 694429:PYRFU_RS08555
uniprot id: G0ECM7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

694429:PYRFU RS03120
gene id: 694429:PYRFU_RS03120
uniprot id: G0EHD2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

694429:PYRFU RS03110
gene id: 694429:PYRFU_RS03110
uniprot id: G0EHD0
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

694429:PYRFU RS02045
gene id: 694429:PYRFU_RS02045
uniprot id: G0EG21
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

694429:PYRFU RS06955
gene id: 694429:PYRFU_RS06955
uniprot id: G0EH50
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS01455
gene id: 694429:PYRFU_RS01455
uniprot id: G0EFA9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

694429:PYRFU RS02495
gene id: 694429:PYRFU_RS02495
uniprot id: G0EGJ2
names: Similarity
messages: Belongs to the archaeal ATPase family.

694429:PYRFU RS09195
gene id: 694429:PYRFU_RS09195
uniprot id: G0ED50
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06765
gene id: 694429:PYRFU_RS06765
uniprot id: G0EGT9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

694429:PYRFU RS06445
gene id: 694429:PYRFU_RS06445
uniprot id: G0EGF2
names: Similarity
messages: Belongs to the UPF0251 family.

694429:PYRFU RS07990
gene id: 694429:PYRFU_RS07990
uniprot id: G0ECB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

694429:PYRFU RS00010
gene id: 694429:PYRFU_RS00010
uniprot id: G0EDN6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694429:PYRFU RS06920
gene id: 694429:PYRFU_RS06920
uniprot id: G0EH43
names: Similarity
messages: Belongs to the UPF0047 family.

694429:PYRFU RS04875
gene id: 694429:PYRFU_RS04875
uniprot id: G0EEM5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

694429:PYRFU RS06960
gene id: 694429:PYRFU_RS06960
uniprot id: G0EH51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

694429:PYRFU RS09810
gene id: 694429:PYRFU_RS09810
uniprot id: G0EFA3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

694429:PYRFU RS00140
gene id: 694429:PYRFU_RS00140
uniprot id: G0EDY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

694429:PYRFU RS08540
gene id: 694429:PYRFU_RS08540
uniprot id: G0ECM4
names: Caution
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS07595
gene id: 694429:PYRFU_RS07595
uniprot id: G0EHP7
names: Subcellular Location Annotation
messages: Cell membrane

694429:PYRFU RS06780
gene id: 694429:PYRFU_RS06780
uniprot id: G0EGU2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

694429:PYRFU RS05245
gene id: 694429:PYRFU_RS05245
uniprot id: G0EF25
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

694429:PYRFU RS08575
gene id: 694429:PYRFU_RS08575
uniprot id: G0ECN1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

694429:PYRFU RS00985
gene id: 694429:PYRFU_RS00985
uniprot id: G0EEU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

694429:PYRFU RS08530
gene id: 694429:PYRFU_RS08530
uniprot id: G0ECM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

694429:PYRFU RS07895
gene id: 694429:PYRFU_RS07895
uniprot id: G0EC95
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

694429:PYRFU RS09700
gene id: 694429:PYRFU_RS09700
uniprot id: G0EDM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

694429:PYRFU RS07005
gene id: 694429:PYRFU_RS07005
uniprot id: G0EH60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

694429:PYRFU RS00895
gene id: 694429:PYRFU_RS00895
uniprot id: G0EEJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

694429:PYRFU RS02810
gene id: 694429:PYRFU_RS02810
uniprot id: G0EGY8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694429:PYRFU RS07130
gene id: 694429:PYRFU_RS07130
uniprot id: G0EH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

694429:PYRFU RS07170
gene id: 694429:PYRFU_RS07170
uniprot id: G0EH92
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

694429:PYRFU RS01150
gene id: 694429:PYRFU_RS01150
uniprot id: G0EEX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

694429:PYRFU RS07775
gene id: 694429:PYRFU_RS07775
uniprot id: G0EC68
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

694429:PYRFU RS07465
gene id: 694429:PYRFU_RS07465
uniprot id: G0EHM1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

694429:PYRFU RS04580
gene id: 694429:PYRFU_RS04580
uniprot id: G0EE96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

694429:PYRFU RS00505
gene id: 694429:PYRFU_RS00505
uniprot id: G0EE51
names: Similarity
messages: Belongs to the UPF0282 family.

694429:PYRFU RS04505
gene id: 694429:PYRFU_RS04505
uniprot id: G0EE81
names: Similarity
messages: Belongs to the UPF0166 family.

694429:PYRFU RS01200
gene id: 694429:PYRFU_RS01200
uniprot id: G0EEY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

694429:PYRFU RS09425
gene id: 694429:PYRFU_RS09425
uniprot id: G0ED94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

694429:PYRFU RS04555
gene id: 694429:PYRFU_RS04555
uniprot id: G0EE91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS09390
gene id: 694429:PYRFU_RS09390
uniprot id: G0ED87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694429:PYRFU RS02470
gene id: 694429:PYRFU_RS02470
uniprot id: G0EGI4
names: Similarity
messages: Belongs to the archaeal ATPase family.

694429:PYRFU RS00015
gene id: 694429:PYRFU_RS00015
uniprot id: G0EDN7
names: Similarity
messages: Belongs to the UPF0215 family.

694429:PYRFU RS03440
gene id: 694429:PYRFU_RS03440
uniprot id: G0ED08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

694429:PYRFU RS06300
gene id: 694429:PYRFU_RS06300
uniprot id: G0EGC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

694429:PYRFU RS09655
gene id: 694429:PYRFU_RS09655
uniprot id: G0EDL2
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS05415
gene id: 694429:PYRFU_RS05415
uniprot id: G0EF58
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

694429:PYRFU RS09730
gene id: 694429:PYRFU_RS09730
uniprot id: G0EDM7
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

694429:PYRFU RS01325
gene id: 694429:PYRFU_RS01325
uniprot id: G0EF82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

694429:PYRFU RS03190
gene id: 694429:PYRFU_RS03190
uniprot id: G0EHE6
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS08240
gene id: 694429:PYRFU_RS08240
uniprot id: G0ECG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

694429:PYRFU RS06295
gene id: 694429:PYRFU_RS06295
uniprot id: G0EGB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

694429:PYRFU RS01990
gene id: 694429:PYRFU_RS01990
uniprot id: G0EFT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

694429:PYRFU RS04445
gene id: 694429:PYRFU_RS04445
uniprot id: G0EE69
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS04890
gene id: 694429:PYRFU_RS04890
uniprot id: G0EEM8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

694429:PYRFU RS08210
gene id: 694429:PYRFU_RS08210
uniprot id: G0ECF6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

694429:PYRFU RS03605
gene id: 694429:PYRFU_RS03605
uniprot id: G0ED40
names: Similarity
messages: Belongs to the HypD family.

694429:PYRFU RS07570
gene id: 694429:PYRFU_RS07570
uniprot id: G0EHP2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

694429:PYRFU RS06805
gene id: 694429:PYRFU_RS06805
uniprot id: G0EGU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694429:PYRFU RS06180
gene id: 694429:PYRFU_RS06180
uniprot id: G0EG95
names: Similarity
messages: Belongs to the hemerythrin family.

694429:PYRFU RS01315
gene id: 694429:PYRFU_RS01315
uniprot id: G0EF80
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

694429:PYRFU RS09525
gene id: 694429:PYRFU_RS09525
uniprot id: G0EDB3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694429:PYRFU RS08865
gene id: 694429:PYRFU_RS08865
uniprot id: G0ECU0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

694429:PYRFU RS05590
gene id: 694429:PYRFU_RS05590
uniprot id: G0EFG3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

694429:PYRFU RS01165
gene id: 694429:PYRFU_RS01165
uniprot id: G0EEX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS08750
gene id: 694429:PYRFU_RS08750
uniprot id: G0ECR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

694429:PYRFU RS04240
gene id: 694429:PYRFU_RS04240
uniprot id: G0EDV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

694429:PYRFU RS00945
gene id: 694429:PYRFU_RS00945
uniprot id: G0EET5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

694429:PYRFU RS00675
gene id: 694429:PYRFU_RS00675
uniprot id: G0EEF8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

694429:PYRFU RS05240
gene id: 694429:PYRFU_RS05240
uniprot id: G0EF24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS05600
gene id: 694429:PYRFU_RS05600
uniprot id: G0EFG5
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.

694429:PYRFU RS00455
gene id: 694429:PYRFU_RS00455
uniprot id: G0EE45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS02165
gene id: 694429:PYRFU_RS02165
uniprot id: G0EG46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

694429:PYRFU RS07110
gene id: 694429:PYRFU_RS07110
uniprot id: G0EH81
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

694429:PYRFU RS05535
gene id: 694429:PYRFU_RS05535
uniprot id: G0EFF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

694429:PYRFU RS04310
gene id: 694429:PYRFU_RS04310
uniprot id: G0EDW7
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

694429:PYRFU RS01535
gene id: 694429:PYRFU_RS01535
uniprot id: G0EFC4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

694429:PYRFU RS08220
gene id: 694429:PYRFU_RS08220
uniprot id: G0ECF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS07880
gene id: 694429:PYRFU_RS07880
uniprot id: G0EC92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

694429:PYRFU RS00975
gene id: 694429:PYRFU_RS00975
uniprot id: G0EEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

694429:PYRFU RS09570
gene id: 694429:PYRFU_RS09570
uniprot id: G0EDJ5
names: Similarity
messages: Belongs to the type IA topoisomerase family.

694429:PYRFU RS07340
gene id: 694429:PYRFU_RS07340
uniprot id: G0EHJ7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694429:PYRFU RS04880
gene id: 694429:PYRFU_RS04880
uniprot id: G0EEM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

694429:PYRFU RS03820
gene id: 694429:PYRFU_RS03820
uniprot id: G0EDG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS09005
gene id: 694429:PYRFU_RS09005
uniprot id: G0ECX0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

694429:PYRFU RS08560
gene id: 694429:PYRFU_RS08560
uniprot id: G0ECM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

694429:PYRFU RS00880
gene id: 694429:PYRFU_RS00880
uniprot id: G0EEJ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

694429:PYRFU RS01010
gene id: 694429:PYRFU_RS01010
uniprot id: G0EEU9
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

694429:PYRFU RS08345
gene id: 694429:PYRFU_RS08345
uniprot id: G0ECI4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

694429:PYRFU RS08745
gene id: 694429:PYRFU_RS08745
uniprot id: G0ECR6
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04395
gene id: 694429:PYRFU_RS04395
uniprot id: G0EE59
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS07470
gene id: 694429:PYRFU_RS07470
uniprot id: G0EHM2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

694429:PYRFU RS07225
gene id: 694429:PYRFU_RS07225
uniprot id: G0EHA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS00225
gene id: 694429:PYRFU_RS00225
uniprot id: G0EE01
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

694429:PYRFU RS01000
gene id: 694429:PYRFU_RS01000
uniprot id: G0EEU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

694429:PYRFU RS02025
gene id: 694429:PYRFU_RS02025
uniprot id: G0EG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694429:PYRFU RS01720
gene id: 694429:PYRFU_RS01720
uniprot id: G0EFN4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

694429:PYRFU RS05370
gene id: 694429:PYRFU_RS05370
uniprot id: G0EF49
names: Similarity
messages: Belongs to the glutaredoxin family.

694429:PYRFU RS08265
gene id: 694429:PYRFU_RS08265
uniprot id: G0ECG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

694429:PYRFU RS03685
gene id: 694429:PYRFU_RS03685
uniprot id: G0EDD2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS02760
gene id: 694429:PYRFU_RS02760
uniprot id: G0EGX8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

694429:PYRFU RS04560
gene id: 694429:PYRFU_RS04560
uniprot id: G0EE92
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

694429:PYRFU RS00685
gene id: 694429:PYRFU_RS00685
uniprot id: G0EEG0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

694429:PYRFU RS04390
gene id: 694429:PYRFU_RS04390
uniprot id: G0EE58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694429:PYRFU RS00210
gene id: 694429:PYRFU_RS00210
uniprot id: G0EDZ8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

694429:PYRFU RS09170
gene id: 694429:PYRFU_RS09170
uniprot id: G0ED44
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

694429:PYRFU RS01120
gene id: 694429:PYRFU_RS01120
uniprot id: G0EEX0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

694429:PYRFU RS00530
gene id: 694429:PYRFU_RS00530
uniprot id: G0EED0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS00970
gene id: 694429:PYRFU_RS00970
uniprot id: G0EEU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

694429:PYRFU RS09135
gene id: 694429:PYRFU_RS09135
uniprot id: G0ECZ5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

694429:PYRFU RS07975
gene id: 694429:PYRFU_RS07975
uniprot id: G0ECB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS03775
gene id: 694429:PYRFU_RS03775
uniprot id: G0EDF1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

694429:PYRFU RS03495
gene id: 694429:PYRFU_RS03495
uniprot id: G0ED19
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

694429:PYRFU RS08160
gene id: 694429:PYRFU_RS08160
uniprot id: G0ECE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

694429:PYRFU RS08590
gene id: 694429:PYRFU_RS08590
uniprot id: G0ECN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

694429:PYRFU RS07450
gene id: 694429:PYRFU_RS07450
uniprot id: G0EHL8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS02720
gene id: 694429:PYRFU_RS02720
uniprot id: G0EGX0
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS01215
gene id: 694429:PYRFU_RS01215
uniprot id: G0EEY9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

694429:PYRFU RS01170
gene id: 694429:PYRFU_RS01170
uniprot id: G0EEY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS06785
gene id: 694429:PYRFU_RS06785
uniprot id: G0EGU3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

694429:PYRFU RS04765
gene id: 694429:PYRFU_RS04765
uniprot id: G0EEK3
names: Similarity
messages: Belongs to the glutaredoxin family.

694429:PYRFU RS08140
gene id: 694429:PYRFU_RS08140
uniprot id: G0ECE1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

694429:PYRFU RS04420
gene id: 694429:PYRFU_RS04420
uniprot id: G0EE64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

694429:PYRFU RS06580
gene id: 694429:PYRFU_RS06580
uniprot id: G0EGQ2
names: Similarity
messages: Belongs to the BtpA family.

694429:PYRFU RS00540
gene id: 694429:PYRFU_RS00540
uniprot id: G0EED2
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

694429:PYRFU RS02195
gene id: 694429:PYRFU_RS02195
uniprot id: G0EG53
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

694429:PYRFU RS03725
gene id: 694429:PYRFU_RS03725
uniprot id: G0EDE0
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

694429:PYRFU RS04965
gene id: 694429:PYRFU_RS04965
uniprot id: G0EEP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS00595
gene id: 694429:PYRFU_RS00595
uniprot id: G0EEE3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

694429:PYRFU RS08285
gene id: 694429:PYRFU_RS08285
uniprot id: G0ECH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

694429:PYRFU RS04800
gene id: 694429:PYRFU_RS04800
uniprot id: G0EEL0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

694429:PYRFU RS02295
gene id: 694429:PYRFU_RS02295
uniprot id: G0EG73
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

694429:PYRFU RS02055
gene id: 694429:PYRFU_RS02055
uniprot id: G0EG23
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

694429:PYRFU RS00850
gene id: 694429:PYRFU_RS00850
uniprot id: G0EEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

694429:PYRFU RS02465
gene id: 694429:PYRFU_RS02465
uniprot id: G0EGI3
names: Similarity
messages: Belongs to the HerA family.

694429:PYRFU RS01185
gene id: 694429:PYRFU_RS01185
uniprot id: G0EEY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

694429:PYRFU RS01495
gene id: 694429:PYRFU_RS01495
uniprot id: G0EFB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

694429:PYRFU RS03995
gene id: 694429:PYRFU_RS03995
uniprot id: G0EDQ8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

694429:PYRFU RS00310
gene id: 694429:PYRFU_RS00310
uniprot id: G0EE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

694429:PYRFU RS01975
gene id: 694429:PYRFU_RS01975
uniprot id: G0EFT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

694429:PYRFU RS04095
gene id: 694429:PYRFU_RS04095
uniprot id: G0EDS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

694429:PYRFU RS00900
gene id: 694429:PYRFU_RS00900
uniprot id: G0EEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

694429:PYRFU RS08415
gene id: 694429:PYRFU_RS08415
uniprot id: G0ECJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

694429:PYRFU RS08180
gene id: 694429:PYRFU_RS08180
uniprot id: G0ECF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS09705
gene id: 694429:PYRFU_RS09705
uniprot id: G0EDM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

694429:PYRFU RS09580
gene id: 694429:PYRFU_RS09580
uniprot id: G0EDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS04415
gene id: 694429:PYRFU_RS04415
uniprot id: G0EE63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

694429:PYRFU RS00770
gene id: 694429:PYRFU_RS00770
uniprot id: G0EEH6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

694429:PYRFU RS07270
gene id: 694429:PYRFU_RS07270
uniprot id: G0EHB2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

694429:PYRFU RS00840
gene id: 694429:PYRFU_RS00840
uniprot id: G0EEI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS06330
gene id: 694429:PYRFU_RS06330
uniprot id: G0EGC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

694429:PYRFU RS04575
gene id: 694429:PYRFU_RS04575
uniprot id: G0EE95
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS05255
gene id: 694429:PYRFU_RS05255
uniprot id: G0EF27
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

694429:PYRFU RS04585
gene id: 694429:PYRFU_RS04585
uniprot id: G0EE97
names: Subcellular Location Annotation
messages: Cell membrane

694429:PYRFU RS06390
gene id: 694429:PYRFU_RS06390
uniprot id: G0EGE0
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

694429:PYRFU RS03155
gene id: 694429:PYRFU_RS03155
uniprot id: G0EHD9
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

694429:PYRFU RS03145
gene id: 694429:PYRFU_RS03145
uniprot id: G0EHD7
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS09405
gene id: 694429:PYRFU_RS09405
uniprot id: G0ED90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

694429:PYRFU RS09240
gene id: 694429:PYRFU_RS09240
uniprot id: G0ED59
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS06700
gene id: 694429:PYRFU_RS06700
uniprot id: G0EGS6
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

694429:PYRFU RS01080
gene id: 694429:PYRFU_RS01080
uniprot id: G0EEW2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

694429:PYRFU RS07790
gene id: 694429:PYRFU_RS07790
uniprot id: G0EC71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

694429:PYRFU RS08335
gene id: 694429:PYRFU_RS08335
uniprot id: G0ECI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

694429:PYRFU RS00235
gene id: 694429:PYRFU_RS00235
uniprot id: G0EE03
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

694429:PYRFU RS09080
gene id: 694429:PYRFU_RS09080
uniprot id: G0ECY4
names: Similarity
messages: Belongs to the peptidase U62 family.

694429:PYRFU RS07565
gene id: 694429:PYRFU_RS07565
uniprot id: G0EHP1
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS00800
gene id: 694429:PYRFU_RS00800
uniprot id: G0EEI2
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

694429:PYRFU RS00060
gene id: 694429:PYRFU_RS00060
uniprot id: G0EDP6
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

694429:PYRFU RS05175
gene id: 694429:PYRFU_RS05175
uniprot id: G0EF11
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

694429:PYRFU RS00930
gene id: 694429:PYRFU_RS00930
uniprot id: G0EET2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

694429:PYRFU RS07610
gene id: 694429:PYRFU_RS07610
uniprot id: G0EHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

694429:PYRFU RS04485
gene id: 694429:PYRFU_RS04485
uniprot id: G0EE77
names: Similarity
messages: Belongs to the HerA family.

694429:PYRFU RS02505
gene id: 694429:PYRFU_RS02505
uniprot id: G0EGJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

694429:PYRFU RS05065
gene id: 694429:PYRFU_RS05065
uniprot id: G0EER4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

694429:PYRFU RS08170
gene id: 694429:PYRFU_RS08170
uniprot id: G0ECE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

694429:PYRFU RS08565
gene id: 694429:PYRFU_RS08565
uniprot id: G0ECM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

694429:PYRFU RS00450
gene id: 694429:PYRFU_RS00450
uniprot id: G0EE44
names: Similarity
messages: Belongs to the PDCD5 family.

694429:PYRFU RS03540
gene id: 694429:PYRFU_RS03540
uniprot id: G0ED28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS07105
gene id: 694429:PYRFU_RS07105
uniprot id: G0EH80
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS04025
gene id: 694429:PYRFU_RS04025
uniprot id: G0EDR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

694429:PYRFU RS09975
gene id: 694429:PYRFU_RS09975
uniprot id: G0EF55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

694429:PYRFU RS02125
gene id: 694429:PYRFU_RS02125
uniprot id: G0EG36
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04295
gene id: 694429:PYRFU_RS04295
uniprot id: G0EDW5
names: Similarity
messages: Belongs to the complex I subunit 3 family.

694429:PYRFU RS03010
gene id: 694429:PYRFU_RS03010
uniprot id: G0EH32
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS06370
gene id: 694429:PYRFU_RS06370
uniprot id: G0EGD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

694429:PYRFU RS07505
gene id: 694429:PYRFU_RS07505
uniprot id: G0EHM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

694429:PYRFU RS08310
gene id: 694429:PYRFU_RS08310
uniprot id: G0ECH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS06740
gene id: 694429:PYRFU_RS06740
uniprot id: G0EGT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694429:PYRFU RS05610
gene id: 694429:PYRFU_RS05610
uniprot id: G0EFG7
names: Similarity
messages: Belongs to the peptidase S8 family.

694429:PYRFU RS02980
gene id: 694429:PYRFU_RS02980
uniprot id: G0EH26
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

694429:PYRFU RS09325
gene id: 694429:PYRFU_RS09325
uniprot id: G0ED73
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS01350
gene id: 694429:PYRFU_RS01350
uniprot id: G0EF88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

694429:PYRFU RS01515
gene id: 694429:PYRFU_RS01515
uniprot id: G0EFC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

694429:PYRFU RS08110
gene id: 694429:PYRFU_RS08110
uniprot id: G0ECD5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

694429:PYRFU RS08955
gene id: 694429:PYRFU_RS08955
uniprot id: G0ECV8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS00190
gene id: 694429:PYRFU_RS00190
uniprot id: G0EDZ4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

694429:PYRFU RS08495
gene id: 694429:PYRFU_RS08495
uniprot id: G0ECL5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

694429:PYRFU RS00725
gene id: 694429:PYRFU_RS00725
uniprot id: G0EEG8
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

694429:PYRFU RS04290
gene id: 694429:PYRFU_RS04290
uniprot id: G0EDW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

694429:PYRFU RS04930
gene id: 694429:PYRFU_RS04930
uniprot id: G0EEN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

694429:PYRFU RS03645
gene id: 694429:PYRFU_RS03645
uniprot id: G0EDC4
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

694429:PYRFU RS01690
gene id: 694429:PYRFU_RS01690
uniprot id: G0EFM8
names: Similarity
messages: Belongs to the HerA family.

694429:PYRFU RS09535
gene id: 694429:PYRFU_RS09535
uniprot id: G0EDB4
names: Similarity
messages: Belongs to the Nth/MutY family.

694429:PYRFU RS08280
gene id: 694429:PYRFU_RS08280
uniprot id: G0ECH1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

694429:PYRFU RS01235
gene id: 694429:PYRFU_RS01235
uniprot id: G0EEZ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS08290
gene id: 694429:PYRFU_RS08290
uniprot id: G0ECH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

694429:PYRFU RS10075
gene id: 694429:PYRFU_RS10075
uniprot id: G0ECY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

694429:PYRFU RS05070
gene id: 694429:PYRFU_RS05070
uniprot id: G0EER5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

694429:PYRFU RS04185
gene id: 694429:PYRFU_RS04185
uniprot id: G0EDU4
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS01030
gene id: 694429:PYRFU_RS01030
uniprot id: G0EEV3
names: Similarity
messages: Belongs to the UPF0147 family.

694429:PYRFU RS01900
gene id: 694429:PYRFU_RS01900
uniprot id: G0EFR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

694429:PYRFU RS06810
gene id: 694429:PYRFU_RS06810
uniprot id: G0EGU8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

694429:PYRFU RS05375
gene id: 694429:PYRFU_RS05375
uniprot id: G0EF50
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

694429:PYRFU RS04665
gene id: 694429:PYRFU_RS04665
uniprot id: G0EEB3
names: Similarity
messages: Belongs to the UPF0173 family.

694429:PYRFU RS06815
gene id: 694429:PYRFU_RS06815
uniprot id: G0EGU9
names: Similarity
messages: Belongs to the peptidase C15 family.

694429:PYRFU RS08215
gene id: 694429:PYRFU_RS08215
uniprot id: G0ECF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

694429:PYRFU RS06585
gene id: 694429:PYRFU_RS06585
uniprot id: G0EGQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

694429:PYRFU RS01795
gene id: 694429:PYRFU_RS01795
uniprot id: G0EFP9
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS05505
gene id: 694429:PYRFU_RS05505
uniprot id: G0EFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

694429:PYRFU RS03490
gene id: 694429:PYRFU_RS03490
uniprot id: G0ED18
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

694429:PYRFU RS09585
gene id: 694429:PYRFU_RS09585
uniprot id: G0EDJ8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

694429:PYRFU RS07335
gene id: 694429:PYRFU_RS07335
uniprot id: G0EHJ6
names: Similarity
messages: Belongs to the ZPR1 family.

694429:PYRFU RS00525
gene id: 694429:PYRFU_RS00525
uniprot id: G0EEC9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS09265
gene id: 694429:PYRFU_RS09265
uniprot id: G0ED61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

694429:PYRFU RS08570
gene id: 694429:PYRFU_RS08570
uniprot id: G0ECN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

694429:PYRFU RS03330
gene id: 694429:PYRFU_RS03330
uniprot id: G0EHH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

694429:PYRFU RS05135
gene id: 694429:PYRFU_RS05135
uniprot id: G0EF03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

694429:PYRFU RS05100
gene id: 694429:PYRFU_RS05100
uniprot id: G0EES1
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS08460
gene id: 694429:PYRFU_RS08460
uniprot id: G0ECK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

694429:PYRFU RS06350
gene id: 694429:PYRFU_RS06350
uniprot id: G0EGD2
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

694429:PYRFU RS00535
gene id: 694429:PYRFU_RS00535
uniprot id: G0EED1
names: Similarity
messages: Belongs to the HerA family.

694429:PYRFU RS07550
gene id: 694429:PYRFU_RS07550
uniprot id: G0EHN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

694429:PYRFU RS02815
gene id: 694429:PYRFU_RS02815
uniprot id: G0EGY9
names: Similarity
messages: Belongs to the UPF0235 family.

694429:PYRFU RS01100
gene id: 694429:PYRFU_RS01100
uniprot id: G0EEW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

694429:PYRFU RS03895
gene id: 694429:PYRFU_RS03895
uniprot id: G0EDH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

694429:PYRFU RS04550
gene id: 694429:PYRFU_RS04550
uniprot id: G0EE90
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

694429:PYRFU RS00715
gene id: 694429:PYRFU_RS00715
uniprot id: G0EEG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

694429:PYRFU RS06325
gene id: 694429:PYRFU_RS06325
uniprot id: G0EGC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

694429:PYRFU RS00605
gene id: 694429:PYRFU_RS00605
uniprot id: G0EEE6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

694429:PYRFU RS03210
gene id: 694429:PYRFU_RS03210
uniprot id: G0EHF0
names: Similarity
messages: Belongs to the UPF0175 family.

694429:PYRFU RS08225
gene id: 694429:PYRFU_RS08225
uniprot id: G0ECG0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694429:PYRFU RS04440
gene id: 694429:PYRFU_RS04440
uniprot id: G0EE68
names: Similarity
messages: Belongs to the PstS family.

694429:PYRFU RS08175
gene id: 694429:PYRFU_RS08175
uniprot id: G0ECE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

694429:PYRFU RS07640
gene id: 694429:PYRFU_RS07640
uniprot id: G0EHQ6
names: Similarity
messages: Belongs to the HerA family.

694429:PYRFU RS01910
gene id: 694429:PYRFU_RS01910
uniprot id: G0EFS1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

694429:PYRFU RS04060
gene id: 694429:PYRFU_RS04060
uniprot id: G0EDS0
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04165
gene id: 694429:PYRFU_RS04165
uniprot id: G0EDU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

694429:PYRFU RS05425
gene id: 694429:PYRFU_RS05425
uniprot id: G0EF60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

694429:PYRFU RS06675
gene id: 694429:PYRFU_RS06675
uniprot id: G0EGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

694429:PYRFU RS06440
gene id: 694429:PYRFU_RS06440
uniprot id: G0EGF1
names: Similarity
messages: Belongs to the aspartokinase family.

694429:PYRFU RS09775
gene id: 694429:PYRFU_RS09775
uniprot id: G0EDN5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

694429:PYRFU RS05010
gene id: 694429:PYRFU_RS05010
uniprot id: G0EEQ2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

694429:PYRFU RS00875
gene id: 694429:PYRFU_RS00875
uniprot id: G0EEJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

694429:PYRFU RS05705
gene id: 694429:PYRFU_RS05705
uniprot id: G0EFI8
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS00590
gene id: 694429:PYRFU_RS00590
uniprot id: G0EEE2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694429:PYRFU RS08950
gene id: 694429:PYRFU_RS08950
uniprot id: G0ECV7
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

694429:PYRFU RS09165
gene id: 694429:PYRFU_RS09165
uniprot id: G0ED01
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS03940
gene id: 694429:PYRFU_RS03940
uniprot id: G0EDI3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

694429:PYRFU RS05780
gene id: 694429:PYRFU_RS05780
uniprot id: G0EFK4
names: Similarity
messages: Belongs to the UPF0175 family.

694429:PYRFU RS01995
gene id: 694429:PYRFU_RS01995
uniprot id: G0EFT8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694429:PYRFU RS08875
gene id: 694429:PYRFU_RS08875
uniprot id: G0ECU2
names: Similarity
messages: Belongs to the AOR/FOR family.

694429:PYRFU RS00260
gene id: 694429:PYRFU_RS00260
uniprot id: G0EE07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

694429:PYRFU RS09875
gene id: 694429:PYRFU_RS09875
uniprot id: G0EDC7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694429:PYRFU RS07460
gene id: 694429:PYRFU_RS07460
uniprot id: G0EHM0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

694429:PYRFU RS05700
gene id: 694429:PYRFU_RS05700
uniprot id: G0EFI7
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

694429:PYRFU RS09635
gene id: 694429:PYRFU_RS09635
uniprot id: G0EDK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

694429:PYRFU RS04330
gene id: 694429:PYRFU_RS04330
uniprot id: G0EDX1
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS02860
gene id: 694429:PYRFU_RS02860
uniprot id: G0EGZ9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

694429:PYRFU RS02975
gene id: 694429:PYRFU_RS02975
uniprot id: G0EH25
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

694429:PYRFU RS02305
gene id: 694429:PYRFU_RS02305
uniprot id: G0EG76
names: Similarity
messages: Belongs to the HepT RNase toxin family.

694429:PYRFU RS07415
gene id: 694429:PYRFU_RS07415
uniprot id: G0EHL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

694429:PYRFU RS06460
gene id: 694429:PYRFU_RS06460
uniprot id: G0EGF5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

694429:PYRFU RS09455
gene id: 694429:PYRFU_RS09455
uniprot id: G0ED99
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

694429:PYRFU RS04595
gene id: 694429:PYRFU_RS04595
uniprot id: G0EE99
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

694429:PYRFU RS09275
gene id: 694429:PYRFU_RS09275
uniprot id: G0ED63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

694429:PYRFU RS08675
gene id: 694429:PYRFU_RS08675
uniprot id: G0ECQ1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

694429:PYRFU RS08930
gene id: 694429:PYRFU_RS08930
uniprot id: G0ECV3
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06320
gene id: 694429:PYRFU_RS06320
uniprot id: G0EGC6
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

694429:PYRFU RS08375
gene id: 694429:PYRFU_RS08375
uniprot id: G0ECJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS09725
gene id: 694429:PYRFU_RS09725
uniprot id: G0EDM6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

694429:PYRFU RS02070
gene id: 694429:PYRFU_RS02070
uniprot id: G0EG26
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

694429:PYRFU RS06640
gene id: 694429:PYRFU_RS06640
uniprot id: G0EGR3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

694429:PYRFU RS01600
gene id: 694429:PYRFU_RS01600
uniprot id: G0EFD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

694429:PYRFU RS07590
gene id: 694429:PYRFU_RS07590
uniprot id: G0EHP6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

694429:PYRFU RS08165
gene id: 694429:PYRFU_RS08165
uniprot id: G0ECE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

694429:PYRFU RS02040
gene id: 694429:PYRFU_RS02040
uniprot id: G0EG20
names: Similarity
messages: Belongs to the glutaredoxin family.

694429:PYRFU RS09330
gene id: 694429:PYRFU_RS09330
uniprot id: G0ED74
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS00575
gene id: 694429:PYRFU_RS00575
uniprot id: G0EED9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

694429:PYRFU RS07825
gene id: 694429:PYRFU_RS07825
uniprot id: G0EC81
names: Similarity
messages: Belongs to the UPF0273 family.

694429:PYRFU RS03015
gene id: 694429:PYRFU_RS03015
uniprot id: G0EH33
names: Similarity
messages: Belongs to the TrpF family.

694429:PYRFU RS08990
gene id: 694429:PYRFU_RS08990
uniprot id: G0ECW6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694429:PYRFU RS08835
gene id: 694429:PYRFU_RS08835
uniprot id: G0ECT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

694429:PYRFU RS03535
gene id: 694429:PYRFU_RS03535
uniprot id: G0ED27
names: Similarity
messages: Belongs to the SUI1 family.

694429:PYRFU RS04900
gene id: 694429:PYRFU_RS04900
uniprot id: G0EEN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

694429:PYRFU RS07480
gene id: 694429:PYRFU_RS07480
uniprot id: G0EHM4
names: Similarity
messages: Belongs to the CutA family.

694429:PYRFU RS03130
gene id: 694429:PYRFU_RS03130
uniprot id: G0EHD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

694429:PYRFU RS04670
gene id: 694429:PYRFU_RS04670
uniprot id: G0EEB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

694429:PYRFU RS07265
gene id: 694429:PYRFU_RS07265
uniprot id: G0EHB1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

694429:PYRFU RS06720
gene id: 694429:PYRFU_RS06720
uniprot id: G0EGT0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

694429:PYRFU RS00990
gene id: 694429:PYRFU_RS00990
uniprot id: G0EEU4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

694429:PYRFU RS03475
gene id: 694429:PYRFU_RS03475
uniprot id: G0ED15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

694429:PYRFU RS05690
gene id: 694429:PYRFU_RS05690
uniprot id: G0EFI5
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

694429:PYRFU RS09120
gene id: 694429:PYRFU_RS09120
uniprot id: G0ECZ2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694429:PYRFU RS08250
gene id: 694429:PYRFU_RS08250
uniprot id: G0ECG5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

694429:PYRFU RS08605
gene id: 694429:PYRFU_RS08605
uniprot id: G0ECN6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

694429:PYRFU RS07850
gene id: 694429:PYRFU_RS07850
uniprot id: G0EC86
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

694429:PYRFU RS01145
gene id: 694429:PYRFU_RS01145
uniprot id: G0EEX5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

694429:PYRFU RS01125
gene id: 694429:PYRFU_RS01125
uniprot id: G0EEX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

694429:PYRFU RS05405
gene id: 694429:PYRFU_RS05405
uniprot id: G0EF56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

694429:PYRFU RS07125
gene id: 694429:PYRFU_RS07125
uniprot id: G0EH83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

694429:PYRFU RS05365
gene id: 694429:PYRFU_RS05365
uniprot id: G0EF48
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

694429:PYRFU RS07630
gene id: 694429:PYRFU_RS07630
uniprot id: G0EHQ4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

694429:PYRFU RS08295
gene id: 694429:PYRFU_RS08295
uniprot id: G0ECH4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

694429:PYRFU RS08195
gene id: 694429:PYRFU_RS08195
uniprot id: G0ECF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS08425
gene id: 694429:PYRFU_RS08425
uniprot id: G0ECK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

694429:PYRFU RS05970
gene id: 694429:PYRFU_RS05970
uniprot id: G0EFX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

694429:PYRFU RS06845
gene id: 694429:PYRFU_RS06845
uniprot id: G0EGV5
names: Similarity
messages: Belongs to the HypA/HybF family.

694429:PYRFU RS01075
gene id: 694429:PYRFU_RS01075
uniprot id: G0EEW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

694429:PYRFU RS09505
gene id: 694429:PYRFU_RS09505
uniprot id: G0EDA9
names: Function
messages: Probably involved in the biogenesis of the ribosome.

694429:PYRFU RS08610
gene id: 694429:PYRFU_RS08610
uniprot id: G0ECN7
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

694429:PYRFU RS06800
gene id: 694429:PYRFU_RS06800
uniprot id: G0EGU6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694429:PYRFU RS06250
gene id: 694429:PYRFU_RS06250
uniprot id: G0EGB0
names: Similarity
messages: Belongs to the class-I fumarase family.

694429:PYRFU RS03905
gene id: 694429:PYRFU_RS03905
uniprot id: G0EDH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS03705
gene id: 694429:PYRFU_RS03705
uniprot id: G0EDD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS03245
gene id: 694429:PYRFU_RS03245
uniprot id: G0EHF6
names: Similarity
messages: Belongs to the AOR/FOR family.

694429:PYRFU RS00830
gene id: 694429:PYRFU_RS00830
uniprot id: G0EEI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

694429:PYRFU RS01625
gene id: 694429:PYRFU_RS01625
uniprot id: G0EFE4
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

694429:PYRFU RS03175
gene id: 694429:PYRFU_RS03175
uniprot id: G0EHE3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

694429:PYRFU RS02080
gene id: 694429:PYRFU_RS02080
uniprot id: G0EG28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

694429:PYRFU RS04925
gene id: 694429:PYRFU_RS04925
uniprot id: G0EEN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

694429:PYRFU RS01935
gene id: 694429:PYRFU_RS01935
uniprot id: G0EFS6
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS02085
gene id: 694429:PYRFU_RS02085
uniprot id: G0EG29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

694429:PYRFU RS09755
gene id: 694429:PYRFU_RS09755
uniprot id: G0EDN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

694429:PYRFU RS06615
gene id: 694429:PYRFU_RS06615
uniprot id: G0EGQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

694429:PYRFU RS04425
gene id: 694429:PYRFU_RS04425
uniprot id: G0EE65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

694429:PYRFU RS05090
gene id: 694429:PYRFU_RS05090
uniprot id: G0EER9
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

694429:PYRFU RS09935
gene id: 694429:PYRFU_RS09935
uniprot id: G0EEC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694429:PYRFU RS01175
gene id: 694429:PYRFU_RS01175
uniprot id: G0EEY1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

694429:PYRFU RS07095
gene id: 694429:PYRFU_RS07095
uniprot id: G0EH78
names: Similarity
messages: Belongs to the glutamate synthase family.

694429:PYRFU RS04600
gene id: 694429:PYRFU_RS04600
uniprot id: G0EEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694429:PYRFU RS00305
gene id: 694429:PYRFU_RS00305
uniprot id: G0EE15
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

694429:PYRFU RS10090
gene id: 694429:PYRFU_RS10090
uniprot id: G0EDN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

694429:PYRFU RS04180
gene id: 694429:PYRFU_RS04180
uniprot id: G0EDU3
names: Similarity
messages: Belongs to the FUN14 family.

694429:PYRFU RS04145
gene id: 694429:PYRFU_RS04145
uniprot id: G0EDT7
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06360
gene id: 694429:PYRFU_RS06360
uniprot id: G0EGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

694429:PYRFU RS06450
gene id: 694429:PYRFU_RS06450
uniprot id: G0EGF3
names: Subcellular Location Annotation
messages: nucleolus

694429:PYRFU RS00470
gene id: 694429:PYRFU_RS00470
uniprot id: G0EE48
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

694429:PYRFU RS01545
gene id: 694429:PYRFU_RS01545
uniprot id: G0EFC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

694429:PYRFU RS07840
gene id: 694429:PYRFU_RS07840
uniprot id: G0EC84
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

694429:PYRFU RS03695
gene id: 694429:PYRFU_RS03695
uniprot id: G0EDD4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

694429:PYRFU RS06710
gene id: 694429:PYRFU_RS06710
uniprot id: G0EGS8
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04785
gene id: 694429:PYRFU_RS04785
uniprot id: G0EEK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

694429:PYRFU RS03500
gene id: 694429:PYRFU_RS03500
uniprot id: G0ED20
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

694429:PYRFU RS07635
gene id: 694429:PYRFU_RS07635
uniprot id: G0EHQ5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

694429:PYRFU RS09545
gene id: 694429:PYRFU_RS09545
uniprot id: G0EDB6
names: Function
messages: Part of a potassium transport system.

694429:PYRFU RS08485
gene id: 694429:PYRFU_RS08485
uniprot id: G0ECL3
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06770
gene id: 694429:PYRFU_RS06770
uniprot id: G0EGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

694429:PYRFU RS02545
gene id: 694429:PYRFU_RS02545
uniprot id: G0EGK6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

694429:PYRFU RS08105
gene id: 694429:PYRFU_RS08105
uniprot id: G0ECD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

694429:PYRFU RS04285
gene id: 694429:PYRFU_RS04285
uniprot id: G0EDW3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

694429:PYRFU RS03915
gene id: 694429:PYRFU_RS03915
uniprot id: G0EDH9
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

694429:PYRFU RS07830
gene id: 694429:PYRFU_RS07830
uniprot id: G0EC82
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

694429:PYRFU RS06670
gene id: 694429:PYRFU_RS06670
uniprot id: G0EGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

694429:PYRFU RS01205
gene id: 694429:PYRFU_RS01205
uniprot id: G0EEY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS04615
gene id: 694429:PYRFU_RS04615
uniprot id: G0EEA3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

694429:PYRFU RS09010
gene id: 694429:PYRFU_RS09010
uniprot id: G0ECX1
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04905
gene id: 694429:PYRFU_RS04905
uniprot id: G0EEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

694429:PYRFU RS03220
gene id: 694429:PYRFU_RS03220
uniprot id: G0EHF2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694429:PYRFU RS04895
gene id: 694429:PYRFU_RS04895
uniprot id: G0EEM9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

694429:PYRFU RS00955
gene id: 694429:PYRFU_RS00955
uniprot id: G0EET7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694429:PYRFU RS00545
gene id: 694429:PYRFU_RS00545
uniprot id: G0EED3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

694429:PYRFU RS05145
gene id: 694429:PYRFU_RS05145
uniprot id: G0EF05
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

694429:PYRFU RS03450
gene id: 694429:PYRFU_RS03450
uniprot id: G0ED10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

694429:PYRFU RS05000
gene id: 694429:PYRFU_RS05000
uniprot id: G0EEQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

694429:PYRFU RS06310
gene id: 694429:PYRFU_RS06310
uniprot id: G0EGC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

694429:PYRFU RS00315
gene id: 694429:PYRFU_RS00315
uniprot id: G0EE17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

694429:PYRFU RS01930
gene id: 694429:PYRFU_RS01930
uniprot id: G0EFS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694429:PYRFU RS03430
gene id: 694429:PYRFU_RS03430
uniprot id: G0ED06
names: Similarity
messages: Belongs to the HypE family.

694429:PYRFU RS06660
gene id: 694429:PYRFU_RS06660
uniprot id: G0EGR8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

694429:PYRFU RS05855
gene id: 694429:PYRFU_RS05855
uniprot id: G0EFV0
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06235
gene id: 694429:PYRFU_RS06235
uniprot id: G0EGA7
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

694429:PYRFU RS04770
gene id: 694429:PYRFU_RS04770
uniprot id: G0EEK4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

694429:PYRFU RS05290
gene id: 694429:PYRFU_RS05290
uniprot id: G0EF34
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS03470
gene id: 694429:PYRFU_RS03470
uniprot id: G0ED14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

694429:PYRFU RS08440
gene id: 694429:PYRFU_RS08440
uniprot id: G0ECK3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

694429:PYRFU RS07245
gene id: 694429:PYRFU_RS07245
uniprot id: G0EHA7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

694429:PYRFU RS06490
gene id: 694429:PYRFU_RS06490
uniprot id: G0EGF9
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

694429:PYRFU RS06470
gene id: 694429:PYRFU_RS06470
uniprot id: G0EGF7
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS06655
gene id: 694429:PYRFU_RS06655
uniprot id: G0EGR6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

694429:PYRFU RS00415
gene id: 694429:PYRFU_RS00415
uniprot id: G0EE37
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

694429:PYRFU RS07915
gene id: 694429:PYRFU_RS07915
uniprot id: G0EC99
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04920
gene id: 694429:PYRFU_RS04920
uniprot id: G0EEN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

694429:PYRFU RS00580
gene id: 694429:PYRFU_RS00580
uniprot id: G0EEE0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

694429:PYRFU RS00995
gene id: 694429:PYRFU_RS00995
uniprot id: G0EEU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

694429:PYRFU RS08200
gene id: 694429:PYRFU_RS08200
uniprot id: G0ECF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

694429:PYRFU RS00960
gene id: 694429:PYRFU_RS00960
uniprot id: G0EET8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

694429:PYRFU RS04910
gene id: 694429:PYRFU_RS04910
uniprot id: G0EEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

694429:PYRFU RS02430
gene id: 694429:PYRFU_RS02430
uniprot id: G0EGH7
names: Similarity
messages: Belongs to the UPF0175 family.

694429:PYRFU RS07845
gene id: 694429:PYRFU_RS07845
uniprot id: G0EC85
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS05250
gene id: 694429:PYRFU_RS05250
uniprot id: G0EF26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

694429:PYRFU RS06775
gene id: 694429:PYRFU_RS06775
uniprot id: G0EGU1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

694429:PYRFU RS04540
gene id: 694429:PYRFU_RS04540
uniprot id: G0EE88
names: Similarity
messages: Belongs to the MEMO1 family.

694429:PYRFU RS02995
gene id: 694429:PYRFU_RS02995
uniprot id: G0EH29
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694429:PYRFU RS09710
gene id: 694429:PYRFU_RS09710
uniprot id: G0EDM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

694429:PYRFU RS08360
gene id: 694429:PYRFU_RS08360
uniprot id: G0ECI7
names: Subcellular Location Annotation
messages: Membrane

694429:PYRFU RS04975
gene id: 694429:PYRFU_RS04975
uniprot id: G0EEP5
names: Similarity
messages: Belongs to the GcvT family.

694429:PYRFU RS00670
gene id: 694429:PYRFU_RS00670
uniprot id: G0EEF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

694429:PYRFU RS05170
gene id: 694429:PYRFU_RS05170
uniprot id: G0EF10
names: Similarity
messages: Belongs to the class-I fumarase family.

694429:PYRFU RS09500
gene id: 694429:PYRFU_RS09500
uniprot id: G0EDA8
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

694429:PYRFU RS01245
gene id: 694429:PYRFU_RS01245
uniprot id: G0EEZ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS02895
gene id: 694429:PYRFU_RS02895
uniprot id: G0EH07
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

694429:PYRFU RS00915
gene id: 694429:PYRFU_RS00915
uniprot id: G0EES9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

694429:PYRFU RS05975
gene id: 694429:PYRFU_RS05975
uniprot id: G0EFX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

694429:PYRFU RS07150
gene id: 694429:PYRFU_RS07150
uniprot id: G0EH88
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

694429:PYRFU RS06650
gene id: 694429:PYRFU_RS06650
uniprot id: G0EGR5
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694429:PYRFU RS00630
gene id: 694429:PYRFU_RS00630
uniprot id: G0EEE9
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.