693661:ARCVE RS07450
gene id: 693661:ARCVE_RS07450
uniprot id: F2KP95
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

693661:ARCVE RS07815
gene id: 693661:ARCVE_RS07815
uniprot id: F2KPP6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

693661:ARCVE RS04920
gene id: 693661:ARCVE_RS04920
uniprot id: F2KSV9
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

693661:ARCVE RS04095
gene id: 693661:ARCVE_RS04095
uniprot id: F2KS07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

693661:ARCVE RS03040
gene id: 693661:ARCVE_RS03040
uniprot id: F2KQS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

693661:ARCVE RS04560
gene id: 693661:ARCVE_RS04560
uniprot id: F2KSG7
names: Similarity
messages: Belongs to the DMRL synthase family.

693661:ARCVE RS00350
gene id: 693661:ARCVE_RS00350
uniprot id: F2KMT8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

693661:ARCVE RS03685
gene id: 693661:ARCVE_RS03685
uniprot id: F2KRK2
names: Similarity
messages: Belongs to the acylphosphatase family.

693661:ARCVE RS00700
gene id: 693661:ARCVE_RS00700
uniprot id: F2KN81
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

693661:ARCVE RS00455
gene id: 693661:ARCVE_RS00455
uniprot id: F2KMV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

693661:ARCVE RS01330
gene id: 693661:ARCVE_RS01330
uniprot id: F2KNZ6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

693661:ARCVE RS04070
gene id: 693661:ARCVE_RS04070
uniprot id: F2KS02
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

693661:ARCVE RS09010
gene id: 693661:ARCVE_RS09010
uniprot id: F2KR01
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS03450
gene id: 693661:ARCVE_RS03450
uniprot id: F2KR85
names: Similarity
messages: Belongs to the RuvB family.

693661:ARCVE RS00235
gene id: 693661:ARCVE_RS00235
uniprot id: F2KMR7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

693661:ARCVE RS08960
gene id: 693661:ARCVE_RS08960
uniprot id: F2KQZ1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07265
gene id: 693661:ARCVE_RS07265
uniprot id: F2KP58
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

693661:ARCVE RS03825
gene id: 693661:ARCVE_RS03825
uniprot id: F2KRN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

693661:ARCVE RS04255
gene id: 693661:ARCVE_RS04255
uniprot id: F2KSB0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

693661:ARCVE RS09945
gene id: 693661:ARCVE_RS09945
uniprot id: F2KS52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

693661:ARCVE RS08565
gene id: 693661:ARCVE_RS08565
uniprot id: F2KQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

693661:ARCVE RS00490
gene id: 693661:ARCVE_RS00490
uniprot id: F2KN38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

693661:ARCVE RS02165
gene id: 693661:ARCVE_RS02165
uniprot id: F2KPW1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04755
gene id: 693661:ARCVE_RS04755
uniprot id: F2KSS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

693661:ARCVE RS09165
gene id: 693661:ARCVE_RS09165
uniprot id: F2KRA4
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

693661:ARCVE RS07915
gene id: 693661:ARCVE_RS07915
uniprot id: F2KPR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS05385
gene id: 693661:ARCVE_RS05385
uniprot id: F2KT63
names: Similarity
messages: Belongs to the UPF0280 family.

693661:ARCVE RS03535
gene id: 693661:ARCVE_RS03535
uniprot id: F2KRH4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

693661:ARCVE RS08505
gene id: 693661:ARCVE_RS08505
uniprot id: F2KQH8
names: Similarity
messages: Belongs to the UPF0107 family.

693661:ARCVE RS05640
gene id: 693661:ARCVE_RS05640
uniprot id: F2KTB0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

693661:ARCVE RS10370
gene id: 693661:ARCVE_RS10370
uniprot id: F2KSK5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

693661:ARCVE RS04955
gene id: 693661:ARCVE_RS04955
uniprot id: F2KSW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

693661:ARCVE RS09130
gene id: 693661:ARCVE_RS09130
uniprot id: F2KR98
names: Similarity
messages: Belongs to the UbiD family.

693661:ARCVE RS09535
gene id: 693661:ARCVE_RS09535
uniprot id: F2KRP5
names: Similarity
messages: Belongs to the AOR/FOR family.

693661:ARCVE RS01860
gene id: 693661:ARCVE_RS01860
uniprot id: F2KPH7
names: Similarity
messages: Belongs to the UPF0282 family.

693661:ARCVE RS08755
gene id: 693661:ARCVE_RS08755
uniprot id: F2KQV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS08930
gene id: 693661:ARCVE_RS08930
uniprot id: F2KQY5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

693661:ARCVE RS05630
gene id: 693661:ARCVE_RS05630
uniprot id: F2KTA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

693661:ARCVE RS10330
gene id: 693661:ARCVE_RS10330
uniprot id: F2KSK0
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS01415
gene id: 693661:ARCVE_RS01415
uniprot id: F2KP14
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS10880
gene id: 693661:ARCVE_RS10880
uniprot id: F2KQZ9
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS01375
gene id: 693661:ARCVE_RS01375
uniprot id: F2KP05
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01490
gene id: 693661:ARCVE_RS01490
uniprot id: F2KP27
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

693661:ARCVE RS06825
gene id: 693661:ARCVE_RS06825
uniprot id: F2KNH1
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

693661:ARCVE RS05780
gene id: 693661:ARCVE_RS05780
uniprot id: F2KMH1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

693661:ARCVE RS10655
gene id: 693661:ARCVE_RS10655
uniprot id: F2KSY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

693661:ARCVE RS07485
gene id: 693661:ARCVE_RS07485
uniprot id: F2KPA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

693661:ARCVE RS00775
gene id: 693661:ARCVE_RS00775
uniprot id: F2KN98
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08635
gene id: 693661:ARCVE_RS08635
uniprot id: F2KQK2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

693661:ARCVE RS08000
gene id: 693661:ARCVE_RS08000
uniprot id: F2KQ08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

693661:ARCVE RS02245
gene id: 693661:ARCVE_RS02245
uniprot id: F2KPX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

693661:ARCVE RS08205
gene id: 693661:ARCVE_RS08205
uniprot id: F2KQ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

693661:ARCVE RS11615
gene id: 693661:ARCVE_RS11615
uniprot id: F2KS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

693661:ARCVE RS05290
gene id: 693661:ARCVE_RS05290
uniprot id: F2KT44
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS01335
gene id: 693661:ARCVE_RS01335
uniprot id: F2KNZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

693661:ARCVE RS08885
gene id: 693661:ARCVE_RS08885
uniprot id: F2KQX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

693661:ARCVE RS07175
gene id: 693661:ARCVE_RS07175
uniprot id: F2KNW7
names: Similarity
messages: Belongs to the class-I fumarase family.

693661:ARCVE RS07920
gene id: 693661:ARCVE_RS07920
uniprot id: F2KPR7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

693661:ARCVE RS05905
gene id: 693661:ARCVE_RS05905
uniprot id: F2KMJ5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS06425
gene id: 693661:ARCVE_RS06425
uniprot id: F2KN19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

693661:ARCVE RS03435
gene id: 693661:ARCVE_RS03435
uniprot id: F2KR82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifH/BchL/ChlL family.
messages: Membrane

693661:ARCVE RS08695
gene id: 693661:ARCVE_RS08695
uniprot id: F2KQL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

693661:ARCVE RS09615
gene id: 693661:ARCVE_RS09615
uniprot id: F2KRR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

693661:ARCVE RS08440
gene id: 693661:ARCVE_RS08440
uniprot id: F2KQG5
names: Similarity
messages: Belongs to the CutA family.

693661:ARCVE RS08915
gene id: 693661:ARCVE_RS08915
uniprot id: F2KQY2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

693661:ARCVE RS09985
gene id: 693661:ARCVE_RS09985
uniprot id: F2KS60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

693661:ARCVE RS09895
gene id: 693661:ARCVE_RS09895
uniprot id: F2KS43
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

693661:ARCVE RS05960
gene id: 693661:ARCVE_RS05960
uniprot id: F2KMK7
names: Subcellular Location Annotation
messages: Cell membrane

693661:ARCVE RS09540
gene id: 693661:ARCVE_RS09540
uniprot id: F2KRP6
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

693661:ARCVE RS05670
gene id: 693661:ARCVE_RS05670
uniprot id: F2KTB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

693661:ARCVE RS01095
gene id: 693661:ARCVE_RS01095
uniprot id: F2KNN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04520
gene id: 693661:ARCVE_RS04520
uniprot id: F2KSF9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

693661:ARCVE RS01795
gene id: 693661:ARCVE_RS01795
uniprot id: F2KPG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS08935
gene id: 693661:ARCVE_RS08935
uniprot id: F2KQY6
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS00995
gene id: 693661:ARCVE_RS00995
uniprot id: F2KNL4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

693661:ARCVE RS01380
gene id: 693661:ARCVE_RS01380
uniprot id: F2KP07
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

693661:ARCVE RS07075
gene id: 693661:ARCVE_RS07075
uniprot id: F2KNU6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

693661:ARCVE RS10485
gene id: 693661:ARCVE_RS10485
uniprot id: F2KSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

693661:ARCVE RS02225
gene id: 693661:ARCVE_RS02225
uniprot id: F2KPX4
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07520
gene id: 693661:ARCVE_RS07520
uniprot id: F2KPB0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

693661:ARCVE RS00950
gene id: 693661:ARCVE_RS00950
uniprot id: F2KNK5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04640
gene id: 693661:ARCVE_RS04640
uniprot id: F2KSQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS07165
gene id: 693661:ARCVE_RS07165
uniprot id: F2KNW5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

693661:ARCVE RS00620
gene id: 693661:ARCVE_RS00620
uniprot id: F2KN65
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS00415
gene id: 693661:ARCVE_RS00415
uniprot id: F2KMV0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

693661:ARCVE RS04785
gene id: 693661:ARCVE_RS04785
uniprot id: F2KST2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

693661:ARCVE RS03770
gene id: 693661:ARCVE_RS03770
uniprot id: F2KRL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

693661:ARCVE RS04540
gene id: 693661:ARCVE_RS04540
uniprot id: F2KSG3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

693661:ARCVE RS10180
gene id: 693661:ARCVE_RS10180
uniprot id: F2KS95
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

693661:ARCVE RS02260
gene id: 693661:ARCVE_RS02260
uniprot id: F2KPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

693661:ARCVE RS08900
gene id: 693661:ARCVE_RS08900
uniprot id: F2KQX9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

693661:ARCVE RS04535
gene id: 693661:ARCVE_RS04535
uniprot id: F2KSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

693661:ARCVE RS07050
gene id: 693661:ARCVE_RS07050
uniprot id: F2KNU1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04735
gene id: 693661:ARCVE_RS04735
uniprot id: F2KSS2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

693661:ARCVE RS01125
gene id: 693661:ARCVE_RS01125
uniprot id: F2KNN7
names: Similarity
messages: Belongs to the UPF0047 family.

693661:ARCVE RS04035
gene id: 693661:ARCVE_RS04035
uniprot id: F2KRZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

693661:ARCVE RS07685
gene id: 693661:ARCVE_RS07685
uniprot id: F2KPM2
names: Similarity
messages: Belongs to the HerA family.

693661:ARCVE RS06420
gene id: 693661:ARCVE_RS06420
uniprot id: F2KN18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

693661:ARCVE RS02955
gene id: 693661:ARCVE_RS02955
uniprot id: F2KQQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

693661:ARCVE RS06640
gene id: 693661:ARCVE_RS06640
uniprot id: F2KND5
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

693661:ARCVE RS08895
gene id: 693661:ARCVE_RS08895
uniprot id: F2KQX8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

693661:ARCVE RS10035
gene id: 693661:ARCVE_RS10035
uniprot id: F2KS70
names: Similarity
messages: Belongs to the MoaB/Mog family.

693661:ARCVE RS02590
gene id: 693661:ARCVE_RS02590
uniprot id: F2KQB7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS06050
gene id: 693661:ARCVE_RS06050
uniprot id: F2KMM5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

693661:ARCVE RS04725
gene id: 693661:ARCVE_RS04725
uniprot id: F2KSS0
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

693661:ARCVE RS08055
gene id: 693661:ARCVE_RS08055
uniprot id: F2KQ19
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

693661:ARCVE RS08770
gene id: 693661:ARCVE_RS08770
uniprot id: F2KQV4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

693661:ARCVE RS04190
gene id: 693661:ARCVE_RS04190
uniprot id: F2KS26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

693661:ARCVE RS09625
gene id: 693661:ARCVE_RS09625
uniprot id: F2KRR4
names: Similarity
messages: Belongs to the UPF0235 family.

693661:ARCVE RS10010
gene id: 693661:ARCVE_RS10010
uniprot id: F2KS65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

693661:ARCVE RS05405
gene id: 693661:ARCVE_RS05405
uniprot id: F2KT67
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

693661:ARCVE RS10450
gene id: 693661:ARCVE_RS10450
uniprot id: F2KSM1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

693661:ARCVE RS08715
gene id: 693661:ARCVE_RS08715
uniprot id: F2KQL6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

693661:ARCVE RS03375
gene id: 693661:ARCVE_RS03375
uniprot id: F2KR70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

693661:ARCVE RS08810
gene id: 693661:ARCVE_RS08810
uniprot id: F2KQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

693661:ARCVE RS09630
gene id: 693661:ARCVE_RS09630
uniprot id: F2KRR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

693661:ARCVE RS02135
gene id: 693661:ARCVE_RS02135
uniprot id: F2KPV5
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

693661:ARCVE RS05830
gene id: 693661:ARCVE_RS05830
uniprot id: F2KMI0
names: Similarity
messages: Belongs to the malic enzymes family.

693661:ARCVE RS08570
gene id: 693661:ARCVE_RS08570
uniprot id: F2KQJ1
names: Similarity
messages: Belongs to the BtpA family.

693661:ARCVE RS04905
gene id: 693661:ARCVE_RS04905
uniprot id: F2KSV6
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS05335
gene id: 693661:ARCVE_RS05335
uniprot id: F2KT53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

693661:ARCVE RS00190
gene id: 693661:ARCVE_RS00190
uniprot id: F2KMQ8
names: Similarity
messages: Belongs to the thymidylate kinase family.

693661:ARCVE RS01565
gene id: 693661:ARCVE_RS01565
uniprot id: F2KP43
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09160
gene id: 693661:ARCVE_RS09160
uniprot id: F2KRA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

693661:ARCVE RS06275
gene id: 693661:ARCVE_RS06275
uniprot id: F2KMY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

693661:ARCVE RS03475
gene id: 693661:ARCVE_RS03475
uniprot id: F2KR89
names: Similarity
messages: Belongs to the UPF0145 family.

693661:ARCVE RS01890
gene id: 693661:ARCVE_RS01890
uniprot id: F2KPI3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

693661:ARCVE RS03035
gene id: 693661:ARCVE_RS03035
uniprot id: F2KQS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

693661:ARCVE RS10460
gene id: 693661:ARCVE_RS10460
uniprot id: F2KSM3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

693661:ARCVE RS07000
gene id: 693661:ARCVE_RS07000
uniprot id: F2KNT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

693661:ARCVE RS06400
gene id: 693661:ARCVE_RS06400
uniprot id: F2KN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

693661:ARCVE RS04870
gene id: 693661:ARCVE_RS04870
uniprot id: F2KSU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

693661:ARCVE RS04865
gene id: 693661:ARCVE_RS04865
uniprot id: F2KSU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

693661:ARCVE RS01655
gene id: 693661:ARCVE_RS01655
uniprot id: F2KPD7
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

693661:ARCVE RS00010
gene id: 693661:ARCVE_RS00010
uniprot id: F2KME7
names: Similarity
messages: Belongs to the arsA ATPase family.

693661:ARCVE RS00460
gene id: 693661:ARCVE_RS00460
uniprot id: F2KMV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

693661:ARCVE RS02615
gene id: 693661:ARCVE_RS02615
uniprot id: F2KQC2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS05305
gene id: 693661:ARCVE_RS05305
uniprot id: F2KT47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

693661:ARCVE RS05990
gene id: 693661:ARCVE_RS05990
uniprot id: F2KML3
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

693661:ARCVE RS00815
gene id: 693661:ARCVE_RS00815
uniprot id: F2KNA6
names: Subcellular Location Annotation
messages: Cell membrane

693661:ARCVE RS04090
gene id: 693661:ARCVE_RS04090
uniprot id: F2KS06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

693661:ARCVE RS06255
gene id: 693661:ARCVE_RS06255
uniprot id: F2KMY4
names: Similarity
messages: Belongs to the DtxR/MntR family.

693661:ARCVE RS01065
gene id: 693661:ARCVE_RS01065
uniprot id: F2KNM7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

693661:ARCVE RS02500
gene id: 693661:ARCVE_RS02500
uniprot id: F2KQ99
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

693661:ARCVE RS05225
gene id: 693661:ARCVE_RS05225
uniprot id: F2KT32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

693661:ARCVE RS06380
gene id: 693661:ARCVE_RS06380
uniprot id: F2KN09
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

693661:ARCVE RS00650
gene id: 693661:ARCVE_RS00650
uniprot id: F2KN71
names: Similarity
messages: Belongs to the DtxR/MntR family.

693661:ARCVE RS09975
gene id: 693661:ARCVE_RS09975
uniprot id: F2KS58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS03890
gene id: 693661:ARCVE_RS03890
uniprot id: F2KRW7
names: Subunit
messages: Homodimer.

693661:ARCVE RS05695
gene id: 693661:ARCVE_RS05695
uniprot id: F2KTC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

693661:ARCVE RS01830
gene id: 693661:ARCVE_RS01830
uniprot id: F2KPH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

693661:ARCVE RS07575
gene id: 693661:ARCVE_RS07575
uniprot id: F2KPC3
names: Similarity
messages: Belongs to the UPF0166 family.

693661:ARCVE RS00375
gene id: 693661:ARCVE_RS00375
uniprot id: F2KMU3
names: Similarity
messages: Belongs to the UPF0179 family.

693661:ARCVE RS02495
gene id: 693661:ARCVE_RS02495
uniprot id: F2KQ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

693661:ARCVE RS06660
gene id: 693661:ARCVE_RS06660
uniprot id: F2KND9
names: Similarity
messages: Belongs to the UPF0111 family.

693661:ARCVE RS00380
gene id: 693661:ARCVE_RS00380
uniprot id: F2KMU4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

693661:ARCVE RS04260
gene id: 693661:ARCVE_RS04260
uniprot id: F2KSB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

693661:ARCVE RS09705
gene id: 693661:ARCVE_RS09705
uniprot id: F2KRT0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01990
gene id: 693661:ARCVE_RS01990
uniprot id: F2KPK3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

693661:ARCVE RS07570
gene id: 693661:ARCVE_RS07570
uniprot id: F2KPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

693661:ARCVE RS07400
gene id: 693661:ARCVE_RS07400
uniprot id: F2KP85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS08170
gene id: 693661:ARCVE_RS08170
uniprot id: F2KQ42
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

693661:ARCVE RS00500
gene id: 693661:ARCVE_RS00500
uniprot id: F2KN40
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05845
gene id: 693661:ARCVE_RS05845
uniprot id: F2KMI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

693661:ARCVE RS09495
gene id: 693661:ARCVE_RS09495
uniprot id: F2KRN7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07900
gene id: 693661:ARCVE_RS07900
uniprot id: F2KPR4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

693661:ARCVE RS05530
gene id: 693661:ARCVE_RS05530
uniprot id: F2KT90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

693661:ARCVE RS06525
gene id: 693661:ARCVE_RS06525
uniprot id: F2KNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

693661:ARCVE RS01620
gene id: 693661:ARCVE_RS01620
uniprot id: F2KPD0
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04910
gene id: 693661:ARCVE_RS04910
uniprot id: F2KSV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

693661:ARCVE RS04690
gene id: 693661:ARCVE_RS04690
uniprot id: F2KSR3
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08265
gene id: 693661:ARCVE_RS08265
uniprot id: F2KQ61
names: Similarity
messages: Belongs to the glutaredoxin family.

693661:ARCVE RS09330
gene id: 693661:ARCVE_RS09330
uniprot id: F2KRD3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

693661:ARCVE RS06655
gene id: 693661:ARCVE_RS06655
uniprot id: F2KND8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

693661:ARCVE RS08120
gene id: 693661:ARCVE_RS08120
uniprot id: F2KQ32
names: Similarity
messages: Belongs to the Ahb/Nir family.

693661:ARCVE RS08090
gene id: 693661:ARCVE_RS08090
uniprot id: F2KQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

693661:ARCVE RS10110
gene id: 693661:ARCVE_RS10110
uniprot id: F2KS82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

693661:ARCVE RS01755
gene id: 693661:ARCVE_RS01755
uniprot id: F2KPF6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

693661:ARCVE RS02015
gene id: 693661:ARCVE_RS02015
uniprot id: F2KPT2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS02265
gene id: 693661:ARCVE_RS02265
uniprot id: F2KPY2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

693661:ARCVE RS00170
gene id: 693661:ARCVE_RS00170
uniprot id: F2KMQ5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS02240
gene id: 693661:ARCVE_RS02240
uniprot id: F2KPX7
names: Similarity
messages: Belongs to the UPF0251 family.

693661:ARCVE RS00240
gene id: 693661:ARCVE_RS00240
uniprot id: F2KMR8
names: Similarity
messages: Belongs to the phosphoribulokinase family.

693661:ARCVE RS01085
gene id: 693661:ARCVE_RS01085
uniprot id: F2KNN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

693661:ARCVE RS07490
gene id: 693661:ARCVE_RS07490
uniprot id: F2KPA3
names: Similarity
messages: Belongs to the HerA family.

693661:ARCVE RS07835
gene id: 693661:ARCVE_RS07835
uniprot id: F2KPQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

693661:ARCVE RS07860
gene id: 693661:ARCVE_RS07860
uniprot id: F2KPQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

693661:ARCVE RS06855
gene id: 693661:ARCVE_RS06855
uniprot id: F2KNH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

693661:ARCVE RS02810
gene id: 693661:ARCVE_RS02810
uniprot id: F2KQM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

693661:ARCVE RS09275
gene id: 693661:ARCVE_RS09275
uniprot id: F2KRC5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

693661:ARCVE RS07495
gene id: 693661:ARCVE_RS07495
uniprot id: F2KPA4
names: Similarity
messages: Belongs to the UPF0212 family.

693661:ARCVE RS06785
gene id: 693661:ARCVE_RS06785
uniprot id: F2KNG3
names: Similarity
messages: Belongs to the aspartokinase family.

693661:ARCVE RS00780
gene id: 693661:ARCVE_RS00780
uniprot id: F2KN99
names: Caution
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09380
gene id: 693661:ARCVE_RS09380
uniprot id: F2KRE4
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

693661:ARCVE RS10210
gene id: 693661:ARCVE_RS10210
uniprot id: F2KSA1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

693661:ARCVE RS03670
gene id: 693661:ARCVE_RS03670
uniprot id: F2KRJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

693661:ARCVE RS05310
gene id: 693661:ARCVE_RS05310
uniprot id: F2KT48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS00710
gene id: 693661:ARCVE_RS00710
uniprot id: F2KN83
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

693661:ARCVE RS06435
gene id: 693661:ARCVE_RS06435
uniprot id: F2KN21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

693661:ARCVE RS00755
gene id: 693661:ARCVE_RS00755
uniprot id: F2KN94
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

693661:ARCVE RS05220
gene id: 693661:ARCVE_RS05220
uniprot id: F2KT31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

693661:ARCVE RS07610
gene id: 693661:ARCVE_RS07610
uniprot id: F2KPK7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

693661:ARCVE RS05890
gene id: 693661:ARCVE_RS05890
uniprot id: F2KMJ2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04195
gene id: 693661:ARCVE_RS04195
uniprot id: F2KS27
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

693661:ARCVE RS01985
gene id: 693661:ARCVE_RS01985
uniprot id: F2KPK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

693661:ARCVE RS10535
gene id: 693661:ARCVE_RS10535
uniprot id: F2KSN8
names: Function
messages: Probably involved in the biogenesis of the ribosome.

693661:ARCVE RS05505
gene id: 693661:ARCVE_RS05505
uniprot id: F2KT86
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

693661:ARCVE RS01365
gene id: 693661:ARCVE_RS01365
uniprot id: F2KP03
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

693661:ARCVE RS08760
gene id: 693661:ARCVE_RS08760
uniprot id: F2KQV2
names: Similarity
messages: Belongs to the PDCD5 family.

693661:ARCVE RS04185
gene id: 693661:ARCVE_RS04185
uniprot id: F2KS25
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS01515
gene id: 693661:ARCVE_RS01515
uniprot id: F2KP32
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

693661:ARCVE RS03425
gene id: 693661:ARCVE_RS03425
uniprot id: F2KR80
names: Similarity
messages: Belongs to the P(II) protein family.

693661:ARCVE RS01955
gene id: 693661:ARCVE_RS01955
uniprot id: F2KPJ6
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

693661:ARCVE RS09665
gene id: 693661:ARCVE_RS09665
uniprot id: F2KRS2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS09360
gene id: 693661:ARCVE_RS09360
uniprot id: F2KRE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

693661:ARCVE RS04565
gene id: 693661:ARCVE_RS04565
uniprot id: F2KSG8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS09610
gene id: 693661:ARCVE_RS09610
uniprot id: F2KRR1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08520
gene id: 693661:ARCVE_RS08520
uniprot id: F2KQI1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04880
gene id: 693661:ARCVE_RS04880
uniprot id: F2KSV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

693661:ARCVE RS10415
gene id: 693661:ARCVE_RS10415
uniprot id: F2KSL4
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

693661:ARCVE RS09025
gene id: 693661:ARCVE_RS09025
uniprot id: F2KR04
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

693661:ARCVE RS10465
gene id: 693661:ARCVE_RS10465
uniprot id: F2KSM4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

693661:ARCVE RS09620
gene id: 693661:ARCVE_RS09620
uniprot id: F2KRR3
names: Similarity
messages: Belongs to the UPF0292 family.

693661:ARCVE RS06920
gene id: 693661:ARCVE_RS06920
uniprot id: F2KNR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

693661:ARCVE RS06675
gene id: 693661:ARCVE_RS06675
uniprot id: F2KNE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

693661:ARCVE RS06950
gene id: 693661:ARCVE_RS06950
uniprot id: F2KNS0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04840
gene id: 693661:ARCVE_RS04840
uniprot id: F2KSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

693661:ARCVE RS06195
gene id: 693661:ARCVE_RS06195
uniprot id: F2KMX2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS06730
gene id: 693661:ARCVE_RS06730
uniprot id: F2KNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS01835
gene id: 693661:ARCVE_RS01835
uniprot id: F2KPH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

693661:ARCVE RS08325
gene id: 693661:ARCVE_RS08325
uniprot id: F2KQ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

693661:ARCVE RS02840
gene id: 693661:ARCVE_RS02840
uniprot id: F2KQN5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

693661:ARCVE RS01050
gene id: 693661:ARCVE_RS01050
uniprot id: F2KNM4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

693661:ARCVE RS04835
gene id: 693661:ARCVE_RS04835
uniprot id: F2KSU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS09225
gene id: 693661:ARCVE_RS09225
uniprot id: F2KRB6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

693661:ARCVE RS00285
gene id: 693661:ARCVE_RS00285
uniprot id: F2KMS6
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

693661:ARCVE RS03925
gene id: 693661:ARCVE_RS03925
uniprot id: F2KRX4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

693661:ARCVE RS05565
gene id: 693661:ARCVE_RS05565
uniprot id: F2KT96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

693661:ARCVE RS04875
gene id: 693661:ARCVE_RS04875
uniprot id: F2KSV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS07250
gene id: 693661:ARCVE_RS07250
uniprot id: F2KP55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

693661:ARCVE RS04160
gene id: 693661:ARCVE_RS04160
uniprot id: F2KS20
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

693661:ARCVE RS10020
gene id: 693661:ARCVE_RS10020
uniprot id: F2KS67
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

693661:ARCVE RS05360
gene id: 693661:ARCVE_RS05360
uniprot id: F2KT58
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04805
gene id: 693661:ARCVE_RS04805
uniprot id: F2KST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS01705
gene id: 693661:ARCVE_RS01705
uniprot id: F2KPE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

693661:ARCVE RS10425
gene id: 693661:ARCVE_RS10425
uniprot id: F2KSL6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS04780
gene id: 693661:ARCVE_RS04780
uniprot id: F2KST1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

693661:ARCVE RS06725
gene id: 693661:ARCVE_RS06725
uniprot id: F2KNF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

693661:ARCVE RS06930
gene id: 693661:ARCVE_RS06930
uniprot id: F2KNR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

693661:ARCVE RS06205
gene id: 693661:ARCVE_RS06205
uniprot id: F2KMX5
names: Similarity
messages: Belongs to the glutaredoxin family.

693661:ARCVE RS01510
gene id: 693661:ARCVE_RS01510
uniprot id: F2KP31
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

693661:ARCVE RS10730
gene id: 693661:ARCVE_RS10730
uniprot id: F2KPV9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

693661:ARCVE RS04545
gene id: 693661:ARCVE_RS04545
uniprot id: F2KSG4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

693661:ARCVE RS09980
gene id: 693661:ARCVE_RS09980
uniprot id: F2KS59
names: Similarity
messages: Belongs to the P(II) protein family.

693661:ARCVE RS06150
gene id: 693661:ARCVE_RS06150
uniprot id: F2KMW5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

693661:ARCVE RS01475
gene id: 693661:ARCVE_RS01475
uniprot id: F2KP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

693661:ARCVE RS02910
gene id: 693661:ARCVE_RS02910
uniprot id: F2KQP9
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

693661:ARCVE RS06550
gene id: 693661:ARCVE_RS06550
uniprot id: F2KNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

693661:ARCVE RS01700
gene id: 693661:ARCVE_RS01700
uniprot id: F2KPE6
names: Subcellular Location Annotation
messages: Cell membrane

693661:ARCVE RS05985
gene id: 693661:ARCVE_RS05985
uniprot id: F2KML2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
messages: Cytoplasm
messages: Homotetramer.

693661:ARCVE RS09855
gene id: 693661:ARCVE_RS09855
uniprot id: F2KS35
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

693661:ARCVE RS03115
gene id: 693661:ARCVE_RS03115
uniprot id: F2KQT8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

693661:ARCVE RS03015
gene id: 693661:ARCVE_RS03015
uniprot id: F2KQR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

693661:ARCVE RS06575
gene id: 693661:ARCVE_RS06575
uniprot id: F2KNC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

693661:ARCVE RS05215
gene id: 693661:ARCVE_RS05215
uniprot id: F2KT30
names: Similarity
messages: Belongs to the SDO1/SBDS family.

693661:ARCVE RS07005
gene id: 693661:ARCVE_RS07005
uniprot id: F2KNT2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS00595
gene id: 693661:ARCVE_RS00595
uniprot id: F2KN59
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

693661:ARCVE RS03165
gene id: 693661:ARCVE_RS03165
uniprot id: F2KR23
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS02525
gene id: 693661:ARCVE_RS02525
uniprot id: F2KQA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

693661:ARCVE RS06395
gene id: 693661:ARCVE_RS06395
uniprot id: F2KN12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

693661:ARCVE RS01470
gene id: 693661:ARCVE_RS01470
uniprot id: F2KP23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

693661:ARCVE RS00250
gene id: 693661:ARCVE_RS00250
uniprot id: F2KMS0
names: Similarity
messages: Belongs to the AOR/FOR family.

693661:ARCVE RS06125
gene id: 693661:ARCVE_RS06125
uniprot id: F2KMN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

693661:ARCVE RS05615
gene id: 693661:ARCVE_RS05615
uniprot id: F2KTA6
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

693661:ARCVE RS10130
gene id: 693661:ARCVE_RS10130
uniprot id: F2KS86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

693661:ARCVE RS03230
gene id: 693661:ARCVE_RS03230
uniprot id: F2KR37
names: Similarity
messages: Belongs to the HerA family.

693661:ARCVE RS03690
gene id: 693661:ARCVE_RS03690
uniprot id: F2KRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

693661:ARCVE RS02105
gene id: 693661:ARCVE_RS02105
uniprot id: F2KPU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

693661:ARCVE RS05155
gene id: 693661:ARCVE_RS05155
uniprot id: F2KT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS02010
gene id: 693661:ARCVE_RS02010
uniprot id: F2KPT1
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

693661:ARCVE RS08250
gene id: 693661:ARCVE_RS08250
uniprot id: F2KQ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

693661:ARCVE RS08425
gene id: 693661:ARCVE_RS08425
uniprot id: F2KQG2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10165
gene id: 693661:ARCVE_RS10165
uniprot id: F2KS93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

693661:ARCVE RS07780
gene id: 693661:ARCVE_RS07780
uniprot id: F2KPN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

693661:ARCVE RS07155
gene id: 693661:ARCVE_RS07155
uniprot id: F2KNW2
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

693661:ARCVE RS03420
gene id: 693661:ARCVE_RS03420
uniprot id: F2KR79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS09095
gene id: 693661:ARCVE_RS09095
uniprot id: F2KR19
names: Similarity
messages: Belongs to the thioesterase PaaI family.

693661:ARCVE RS00565
gene id: 693661:ARCVE_RS00565
uniprot id: F2KN53
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

693661:ARCVE RS04675
gene id: 693661:ARCVE_RS04675
uniprot id: F2KSR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

693661:ARCVE RS04480
gene id: 693661:ARCVE_RS04480
uniprot id: F2KSF0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

693661:ARCVE RS06925
gene id: 693661:ARCVE_RS06925
uniprot id: F2KNR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

693661:ARCVE RS02945
gene id: 693661:ARCVE_RS02945
uniprot id: F2KQQ6
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

693661:ARCVE RS03965
gene id: 693661:ARCVE_RS03965
uniprot id: F2KRY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

693661:ARCVE RS06270
gene id: 693661:ARCVE_RS06270
uniprot id: F2KMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

693661:ARCVE RS05590
gene id: 693661:ARCVE_RS05590
uniprot id: F2KTA1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

693661:ARCVE RS02150
gene id: 693661:ARCVE_RS02150
uniprot id: F2KPV8
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

693661:ARCVE RS04830
gene id: 693661:ARCVE_RS04830
uniprot id: F2KSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

693661:ARCVE RS03045
gene id: 693661:ARCVE_RS03045
uniprot id: F2KQS4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

693661:ARCVE RS03920
gene id: 693661:ARCVE_RS03920
uniprot id: F2KRX3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

693661:ARCVE RS08545
gene id: 693661:ARCVE_RS08545
uniprot id: F2KQI6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01615
gene id: 693661:ARCVE_RS01615
uniprot id: F2KP52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS07395
gene id: 693661:ARCVE_RS07395
uniprot id: F2KP84
names: Similarity
messages: Belongs to the UPF0045 family.

693661:ARCVE RS00435
gene id: 693661:ARCVE_RS00435
uniprot id: F2KMV4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

693661:ARCVE RS06155
gene id: 693661:ARCVE_RS06155
uniprot id: F2KMW6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

693661:ARCVE RS06005
gene id: 693661:ARCVE_RS06005
uniprot id: F2KML6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

693661:ARCVE RS08025
gene id: 693661:ARCVE_RS08025
uniprot id: F2KQ13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

693661:ARCVE RS06900
gene id: 693661:ARCVE_RS06900
uniprot id: F2KNR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

693661:ARCVE RS08080
gene id: 693661:ARCVE_RS08080
uniprot id: F2KQ25
names: Subcellular Location Annotation
messages: Mitochondrion

693661:ARCVE RS09085
gene id: 693661:ARCVE_RS09085
uniprot id: F2KR17
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

693661:ARCVE RS09105
gene id: 693661:ARCVE_RS09105
uniprot id: F2KR21
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

693661:ARCVE RS00615
gene id: 693661:ARCVE_RS00615
uniprot id: F2KN64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

693661:ARCVE RS02205
gene id: 693661:ARCVE_RS02205
uniprot id: F2KPX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

693661:ARCVE RS08050
gene id: 693661:ARCVE_RS08050
uniprot id: F2KQ18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

693661:ARCVE RS06870
gene id: 693661:ARCVE_RS06870
uniprot id: F2KNH9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

693661:ARCVE RS09780
gene id: 693661:ARCVE_RS09780
uniprot id: F2KRU5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

693661:ARCVE RS07930
gene id: 693661:ARCVE_RS07930
uniprot id: F2KPR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

693661:ARCVE RS09825
gene id: 693661:ARCVE_RS09825
uniprot id: F2KRV4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

693661:ARCVE RS00440
gene id: 693661:ARCVE_RS00440
uniprot id: F2KMV5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

693661:ARCVE RS04790
gene id: 693661:ARCVE_RS04790
uniprot id: F2KST3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS09865
gene id: 693661:ARCVE_RS09865
uniprot id: F2KS37
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

693661:ARCVE RS00880
gene id: 693661:ARCVE_RS00880
uniprot id: F2KNJ2
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

693661:ARCVE RS09210
gene id: 693661:ARCVE_RS09210
uniprot id: F2KRB3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02550
gene id: 693661:ARCVE_RS02550
uniprot id: F2KQA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

693661:ARCVE RS03170
gene id: 693661:ARCVE_RS03170
uniprot id: F2KR24
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08790
gene id: 693661:ARCVE_RS08790
uniprot id: F2KQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

693661:ARCVE RS08785
gene id: 693661:ARCVE_RS08785
uniprot id: F2KQV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

693661:ARCVE RS08030
gene id: 693661:ARCVE_RS08030
uniprot id: F2KQ14
names: Similarity
messages: Belongs to the HisA/HisF family.

693661:ARCVE RS03780
gene id: 693661:ARCVE_RS03780
uniprot id: F2KRM0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

693661:ARCVE RS08555
gene id: 693661:ARCVE_RS08555
uniprot id: F2KQI8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

693661:ARCVE RS05865
gene id: 693661:ARCVE_RS05865
uniprot id: F2KMI7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS09700
gene id: 693661:ARCVE_RS09700
uniprot id: F2KRS9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

693661:ARCVE RS08345
gene id: 693661:ARCVE_RS08345
uniprot id: F2KQ77
names: Similarity
messages: Belongs to the UPF0047 family.

693661:ARCVE RS01685
gene id: 693661:ARCVE_RS01685
uniprot id: F2KPE3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05460
gene id: 693661:ARCVE_RS05460
uniprot id: F2KT76
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

693661:ARCVE RS09065
gene id: 693661:ARCVE_RS09065
uniprot id: F2KR13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

693661:ARCVE RS08480
gene id: 693661:ARCVE_RS08480
uniprot id: F2KQH3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

693661:ARCVE RS09110
gene id: 693661:ARCVE_RS09110
uniprot id: F2KR94
names: Similarity
messages: Belongs to the AAA ATPase family.

693661:ARCVE RS04075
gene id: 693661:ARCVE_RS04075
uniprot id: F2KS03
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

693661:ARCVE RS03500
gene id: 693661:ARCVE_RS03500
uniprot id: F2KRG7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS03865
gene id: 693661:ARCVE_RS03865
uniprot id: F2KRW2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

693661:ARCVE RS06800
gene id: 693661:ARCVE_RS06800
uniprot id: F2KNG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

693661:ARCVE RS06770
gene id: 693661:ARCVE_RS06770
uniprot id: F2KNG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05175
gene id: 693661:ARCVE_RS05175
uniprot id: F2KT22
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09570
gene id: 693661:ARCVE_RS09570
uniprot id: F2KRQ3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

693661:ARCVE RS03870
gene id: 693661:ARCVE_RS03870
uniprot id: F2KRW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

693661:ARCVE RS02505
gene id: 693661:ARCVE_RS02505
uniprot id: F2KQA0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

693661:ARCVE RS05165
gene id: 693661:ARCVE_RS05165
uniprot id: F2KT20
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

693661:ARCVE RS07600
gene id: 693661:ARCVE_RS07600
uniprot id: F2KPC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

693661:ARCVE RS09965
gene id: 693661:ARCVE_RS09965
uniprot id: F2KS56
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

693661:ARCVE RS03710
gene id: 693661:ARCVE_RS03710
uniprot id: F2KRK6
names: Function
messages: Part of a potassium transport system.

693661:ARCVE RS04995
gene id: 693661:ARCVE_RS04995
uniprot id: F2KSX4
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS02145
gene id: 693661:ARCVE_RS02145
uniprot id: F2KPV7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS06145
gene id: 693661:ARCVE_RS06145
uniprot id: F2KMP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

693661:ARCVE RS09580
gene id: 693661:ARCVE_RS09580
uniprot id: F2KRQ5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04990
gene id: 693661:ARCVE_RS04990
uniprot id: F2KSX3
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04795
gene id: 693661:ARCVE_RS04795
uniprot id: F2KST4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

693661:ARCVE RS06580
gene id: 693661:ARCVE_RS06580
uniprot id: F2KNC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

693661:ARCVE RS01505
gene id: 693661:ARCVE_RS01505
uniprot id: F2KP30
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

693661:ARCVE RS05350
gene id: 693661:ARCVE_RS05350
uniprot id: F2KT56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

693661:ARCVE RS00935
gene id: 693661:ARCVE_RS00935
uniprot id: F2KNK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

693661:ARCVE RS03520
gene id: 693661:ARCVE_RS03520
uniprot id: F2KRH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

693661:ARCVE RS10645
gene id: 693661:ARCVE_RS10645
uniprot id: F2KSY4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS03735
gene id: 693661:ARCVE_RS03735
uniprot id: F2KRL1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

693661:ARCVE RS07270
gene id: 693661:ARCVE_RS07270
uniprot id: F2KP59
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

693661:ARCVE RS01950
gene id: 693661:ARCVE_RS01950
uniprot id: F2KPJ5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS05935
gene id: 693661:ARCVE_RS05935
uniprot id: F2KMK1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS01500
gene id: 693661:ARCVE_RS01500
uniprot id: F2KP29
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

693661:ARCVE RS04670
gene id: 693661:ARCVE_RS04670
uniprot id: F2KSQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

693661:ARCVE RS06230
gene id: 693661:ARCVE_RS06230
uniprot id: F2KMY0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

693661:ARCVE RS05235
gene id: 693661:ARCVE_RS05235
uniprot id: F2KT34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS07625
gene id: 693661:ARCVE_RS07625
uniprot id: F2KPL0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

693661:ARCVE RS02960
gene id: 693661:ARCVE_RS02960
uniprot id: F2KQQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

693661:ARCVE RS04720
gene id: 693661:ARCVE_RS04720
uniprot id: F2KSR9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

693661:ARCVE RS06165
gene id: 693661:ARCVE_RS06165
uniprot id: F2KMW8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

693661:ARCVE RS08995
gene id: 693661:ARCVE_RS08995
uniprot id: F2KQZ8
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

693661:ARCVE RS06665
gene id: 693661:ARCVE_RS06665
uniprot id: F2KNE0
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).

693661:ARCVE RS08280
gene id: 693661:ARCVE_RS08280
uniprot id: F2KQ64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

693661:ARCVE RS06940
gene id: 693661:ARCVE_RS06940
uniprot id: F2KNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

693661:ARCVE RS07925
gene id: 693661:ARCVE_RS07925
uniprot id: F2KPR8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

693661:ARCVE RS05210
gene id: 693661:ARCVE_RS05210
uniprot id: F2KT29
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

693661:ARCVE RS09635
gene id: 693661:ARCVE_RS09635
uniprot id: F2KRR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

693661:ARCVE RS04860
gene id: 693661:ARCVE_RS04860
uniprot id: F2KSU7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

693661:ARCVE RS03815
gene id: 693661:ARCVE_RS03815
uniprot id: F2KRM8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

693661:ARCVE RS06740
gene id: 693661:ARCVE_RS06740
uniprot id: F2KNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS09845
gene id: 693661:ARCVE_RS09845
uniprot id: F2KRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

693661:ARCVE RS06720
gene id: 693661:ARCVE_RS06720
uniprot id: F2KNF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

693661:ARCVE RS01485
gene id: 693661:ARCVE_RS01485
uniprot id: F2KP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

693661:ARCVE RS10420
gene id: 693661:ARCVE_RS10420
uniprot id: F2KSL5
names: Similarity
messages: Belongs to the citrate synthase family.

693661:ARCVE RS05735
gene id: 693661:ARCVE_RS05735
uniprot id: F2KTD0
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

693661:ARCVE RS01370
gene id: 693661:ARCVE_RS01370
uniprot id: F2KP04
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

693661:ARCVE RS07080
gene id: 693661:ARCVE_RS07080
uniprot id: F2KNU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

693661:ARCVE RS09730
gene id: 693661:ARCVE_RS09730
uniprot id: F2KRT5
names: Similarity
messages: Belongs to the UPF0146 family.

693661:ARCVE RS01340
gene id: 693661:ARCVE_RS01340
uniprot id: F2KNZ8
names: Similarity
messages: Belongs to the UPF0248 family.

693661:ARCVE RS01760
gene id: 693661:ARCVE_RS01760
uniprot id: F2KPF7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

693661:ARCVE RS07375
gene id: 693661:ARCVE_RS07375
uniprot id: F2KP80
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

693661:ARCVE RS01790
gene id: 693661:ARCVE_RS01790
uniprot id: F2KPG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

693661:ARCVE RS05920
gene id: 693661:ARCVE_RS05920
uniprot id: F2KMJ8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

693661:ARCVE RS00805
gene id: 693661:ARCVE_RS00805
uniprot id: F2KNA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

693661:ARCVE RS00290
gene id: 693661:ARCVE_RS00290
uniprot id: F2KMS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

693661:ARCVE RS05365
gene id: 693661:ARCVE_RS05365
uniprot id: F2KT59
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

693661:ARCVE RS05115
gene id: 693661:ARCVE_RS05115
uniprot id: F2KT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

693661:ARCVE RS06715
gene id: 693661:ARCVE_RS06715
uniprot id: F2KNF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

693661:ARCVE RS02560
gene id: 693661:ARCVE_RS02560
uniprot id: F2KQB1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS07775
gene id: 693661:ARCVE_RS07775
uniprot id: F2KPN8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

693661:ARCVE RS09115
gene id: 693661:ARCVE_RS09115
uniprot id: F2KR95
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

693661:ARCVE RS08255
gene id: 693661:ARCVE_RS08255
uniprot id: F2KQ59
names: Similarity
messages: Belongs to the DtxR/MntR family.

693661:ARCVE RS08975
gene id: 693661:ARCVE_RS08975
uniprot id: F2KQZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

693661:ARCVE RS07470
gene id: 693661:ARCVE_RS07470
uniprot id: F2KP99
names: Similarity
messages: Belongs to the band 7/mec-2 family.

693661:ARCVE RS06875
gene id: 693661:ARCVE_RS06875
uniprot id: F2KNI0
names: Similarity
messages: Belongs to the archaeal-type GPI family.

693661:ARCVE RS03820
gene id: 693661:ARCVE_RS03820
uniprot id: F2KRM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

693661:ARCVE RS05665
gene id: 693661:ARCVE_RS05665
uniprot id: F2KTB5
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

693661:ARCVE RS07895
gene id: 693661:ARCVE_RS07895
uniprot id: F2KPR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

693661:ARCVE RS03955
gene id: 693661:ARCVE_RS03955
uniprot id: F2KRY1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

693661:ARCVE RS09970
gene id: 693661:ARCVE_RS09970
uniprot id: F2KS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

693661:ARCVE RS04210
gene id: 693661:ARCVE_RS04210
uniprot id: F2KS30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

693661:ARCVE RS04175
gene id: 693661:ARCVE_RS04175
uniprot id: F2KS23
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

693661:ARCVE RS09055
gene id: 693661:ARCVE_RS09055
uniprot id: F2KR11
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

693661:ARCVE RS06040
gene id: 693661:ARCVE_RS06040
uniprot id: F2KMM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

693661:ARCVE RS04180
gene id: 693661:ARCVE_RS04180
uniprot id: F2KS24
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

693661:ARCVE RS06280
gene id: 693661:ARCVE_RS06280
uniprot id: F2KMZ0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class II subfamily.
messages: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

693661:ARCVE RS10850
gene id: 693661:ARCVE_RS10850
uniprot id: F2KQ33
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

693661:ARCVE RS10495
gene id: 693661:ARCVE_RS10495
uniprot id: F2KSN0
names: Similarity
messages: Belongs to the UPF0215 family.

693661:ARCVE RS01120
gene id: 693661:ARCVE_RS01120
uniprot id: F2KNN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

693661:ARCVE RS05045
gene id: 693661:ARCVE_RS05045
uniprot id: F2KSZ8
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

693661:ARCVE RS04740
gene id: 693661:ARCVE_RS04740
uniprot id: F2KSS3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

693661:ARCVE RS08775
gene id: 693661:ARCVE_RS08775
uniprot id: F2KQV5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

693661:ARCVE RS00520
gene id: 693661:ARCVE_RS00520
uniprot id: F2KN44
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08295
gene id: 693661:ARCVE_RS08295
uniprot id: F2KQ67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05895
gene id: 693661:ARCVE_RS05895
uniprot id: F2KMJ3
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS05610
gene id: 693661:ARCVE_RS05610
uniprot id: F2KTA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

693661:ARCVE RS00705
gene id: 693661:ARCVE_RS00705
uniprot id: F2KN82
names: Similarity
messages: Belongs to the HypE family.

693661:ARCVE RS07295
gene id: 693661:ARCVE_RS07295
uniprot id: F2KP64
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

693661:ARCVE RS03025
gene id: 693661:ARCVE_RS03025
uniprot id: F2KQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

693661:ARCVE RS04710
gene id: 693661:ARCVE_RS04710
uniprot id: F2KSR7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

693661:ARCVE RS05980
gene id: 693661:ARCVE_RS05980
uniprot id: F2KML1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01225
gene id: 693661:ARCVE_RS01225
uniprot id: F2KNQ7
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

693661:ARCVE RS03960
gene id: 693661:ARCVE_RS03960
uniprot id: F2KRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS03110
gene id: 693661:ARCVE_RS03110
uniprot id: F2KQT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

693661:ARCVE RS03760
gene id: 693661:ARCVE_RS03760
uniprot id: F2KRL5
names: Subunit
messages: Homotetramer.

693661:ARCVE RS08020
gene id: 693661:ARCVE_RS08020
uniprot id: F2KQ12
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

693661:ARCVE RS06710
gene id: 693661:ARCVE_RS06710
uniprot id: F2KNE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS10390
gene id: 693661:ARCVE_RS10390
uniprot id: F2KSK9
names: Similarity
messages: Belongs to the UPF0175 family.

693661:ARCVE RS04895
gene id: 693661:ARCVE_RS04895
uniprot id: F2KSV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

693661:ARCVE RS05190
gene id: 693661:ARCVE_RS05190
uniprot id: F2KT25
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

693661:ARCVE RS10580
gene id: 693661:ARCVE_RS10580
uniprot id: F2KSP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

693661:ARCVE RS02795
gene id: 693661:ARCVE_RS02795
uniprot id: F2KQM6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

693661:ARCVE RS02330
gene id: 693661:ARCVE_RS02330
uniprot id: F2KPZ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

693661:ARCVE RS05440
gene id: 693661:ARCVE_RS05440
uniprot id: F2KT72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

693661:ARCVE RS07665
gene id: 693661:ARCVE_RS07665
uniprot id: F2KPL8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

693661:ARCVE RS10620
gene id: 693661:ARCVE_RS10620
uniprot id: F2KSX9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04270
gene id: 693661:ARCVE_RS04270
uniprot id: F2KSB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS01910
gene id: 693661:ARCVE_RS01910
uniprot id: F2KPI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

693661:ARCVE RS00385
gene id: 693661:ARCVE_RS00385
uniprot id: F2KMU5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

693661:ARCVE RS07980
gene id: 693661:ARCVE_RS07980
uniprot id: F2KPS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

693661:ARCVE RS09640
gene id: 693661:ARCVE_RS09640
uniprot id: F2KRR7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

693661:ARCVE RS08165
gene id: 693661:ARCVE_RS08165
uniprot id: F2KQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS02965
gene id: 693661:ARCVE_RS02965
uniprot id: F2KQR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05300
gene id: 693661:ARCVE_RS05300
uniprot id: F2KT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

693661:ARCVE RS01495
gene id: 693661:ARCVE_RS01495
uniprot id: F2KP28
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

693661:ARCVE RS07620
gene id: 693661:ARCVE_RS07620
uniprot id: F2KPK9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

693661:ARCVE RS02510
gene id: 693661:ARCVE_RS02510
uniprot id: F2KQA1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

693661:ARCVE RS04395
gene id: 693661:ARCVE_RS04395
uniprot id: F2KSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS10675
gene id: 693661:ARCVE_RS10675
uniprot id: F2KSZ0
names: Similarity
messages: Belongs to the VPS29 family.
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

693661:ARCVE RS07865
gene id: 693661:ARCVE_RS07865
uniprot id: F2KPQ7
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS02250
gene id: 693661:ARCVE_RS02250
uniprot id: F2KPX9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

693661:ARCVE RS05855
gene id: 693661:ARCVE_RS05855
uniprot id: F2KMI5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

693661:ARCVE RS05450
gene id: 693661:ARCVE_RS05450
uniprot id: F2KT74
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04960
gene id: 693661:ARCVE_RS04960
uniprot id: F2KSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

693661:ARCVE RS05320
gene id: 693661:ARCVE_RS05320
uniprot id: F2KT50
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

693661:ARCVE RS07760
gene id: 693661:ARCVE_RS07760
uniprot id: F2KPN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

693661:ARCVE RS05340
gene id: 693661:ARCVE_RS05340
uniprot id: F2KT54
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

693661:ARCVE RS09915
gene id: 693661:ARCVE_RS09915
uniprot id: F2KS46
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

693661:ARCVE RS01660
gene id: 693661:ARCVE_RS01660
uniprot id: F2KPD8
names: Similarity
messages: Belongs to the FTR family.

693661:ARCVE RS03875
gene id: 693661:ARCVE_RS03875
uniprot id: F2KRW4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09045
gene id: 693661:ARCVE_RS09045
uniprot id: F2KR09
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

693661:ARCVE RS04815
gene id: 693661:ARCVE_RS04815
uniprot id: F2KST8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

693661:ARCVE RS05170
gene id: 693661:ARCVE_RS05170
uniprot id: F2KT21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

693661:ARCVE RS08310
gene id: 693661:ARCVE_RS08310
uniprot id: F2KQ70
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04155
gene id: 693661:ARCVE_RS04155
uniprot id: F2KS19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

693661:ARCVE RS08300
gene id: 693661:ARCVE_RS08300
uniprot id: F2KQ68
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02875
gene id: 693661:ARCVE_RS02875
uniprot id: F2KQP2
names: Caution
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS10765
gene id: 693661:ARCVE_RS10765
uniprot id: F2KS05
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS05145
gene id: 693661:ARCVE_RS05145
uniprot id: F2KT16
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

693661:ARCVE RS10070
gene id: 693661:ARCVE_RS10070
uniprot id: F2KS77
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS06650
gene id: 693661:ARCVE_RS06650
uniprot id: F2KND7
names: Similarity
messages: Belongs to the GARS family.

693661:ARCVE RS08410
gene id: 693661:ARCVE_RS08410
uniprot id: F2KQF9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

693661:ARCVE RS09575
gene id: 693661:ARCVE_RS09575
uniprot id: F2KRQ4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

693661:ARCVE RS02535
gene id: 693661:ARCVE_RS02535
uniprot id: F2KQA6
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS08780
gene id: 693661:ARCVE_RS08780
uniprot id: F2KQV6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

693661:ARCVE RS06850
gene id: 693661:ARCVE_RS06850
uniprot id: F2KNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

693661:ARCVE RS08730
gene id: 693661:ARCVE_RS08730
uniprot id: F2KQL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS00695
gene id: 693661:ARCVE_RS00695
uniprot id: F2KN80
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

693661:ARCVE RS08070
gene id: 693661:ARCVE_RS08070
uniprot id: F2KQ22
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

693661:ARCVE RS03860
gene id: 693661:ARCVE_RS03860
uniprot id: F2KRW1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

693661:ARCVE RS05655
gene id: 693661:ARCVE_RS05655
uniprot id: F2KTB3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01970
gene id: 693661:ARCVE_RS01970
uniprot id: F2KPJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

693661:ARCVE RS03950
gene id: 693661:ARCVE_RS03950
uniprot id: F2KRX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

693661:ARCVE RS00750
gene id: 693661:ARCVE_RS00750
uniprot id: F2KN92
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS03805
gene id: 693661:ARCVE_RS03805
uniprot id: F2KRM6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

693661:ARCVE RS03070
gene id: 693661:ARCVE_RS03070
uniprot id: F2KQS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

693661:ARCVE RS08285
gene id: 693661:ARCVE_RS08285
uniprot id: F2KQ65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

693661:ARCVE RS01180
gene id: 693661:ARCVE_RS01180
uniprot id: F2KNP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

693661:ARCVE RS06910
gene id: 693661:ARCVE_RS06910
uniprot id: F2KNR2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

693661:ARCVE RS08060
gene id: 693661:ARCVE_RS08060
uniprot id: F2KQ20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

693661:ARCVE RS02005
gene id: 693661:ARCVE_RS02005
uniprot id: F2KPT0
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

693661:ARCVE RS05270
gene id: 693661:ARCVE_RS05270
uniprot id: F2KT41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

693661:ARCVE RS05240
gene id: 693661:ARCVE_RS05240
uniprot id: F2KT35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS00320
gene id: 693661:ARCVE_RS00320
uniprot id: F2KMT3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

693661:ARCVE RS04915
gene id: 693661:ARCVE_RS04915
uniprot id: F2KSV8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

693661:ARCVE RS09755
gene id: 693661:ARCVE_RS09755
uniprot id: F2KRU0
names: Similarity
messages: Belongs to the AAA ATPase family.

693661:ARCVE RS06175
gene id: 693661:ARCVE_RS06175
uniprot id: F2KMX0
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

693661:ARCVE RS08805
gene id: 693661:ARCVE_RS08805
uniprot id: F2KQW1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

693661:ARCVE RS02870
gene id: 693661:ARCVE_RS02870
uniprot id: F2KQP1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

693661:ARCVE RS04715
gene id: 693661:ARCVE_RS04715
uniprot id: F2KSR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02255
gene id: 693661:ARCVE_RS02255
uniprot id: F2KPY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

693661:ARCVE RS02035
gene id: 693661:ARCVE_RS02035
uniprot id: F2KPT6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

693661:ARCVE RS05740
gene id: 693661:ARCVE_RS05740
uniprot id: F2KTD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

693661:ARCVE RS06045
gene id: 693661:ARCVE_RS06045
uniprot id: F2KMM4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

693661:ARCVE RS01385
gene id: 693661:ARCVE_RS01385
uniprot id: F2KP08
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS01630
gene id: 693661:ARCVE_RS01630
uniprot id: F2KPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

693661:ARCVE RS07475
gene id: 693661:ARCVE_RS07475
uniprot id: F2KPA0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

693661:ARCVE RS05315
gene id: 693661:ARCVE_RS05315
uniprot id: F2KT49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

693661:ARCVE RS02700
gene id: 693661:ARCVE_RS02700
uniprot id: F2KQD8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

693661:ARCVE RS01895
gene id: 693661:ARCVE_RS01895
uniprot id: F2KPI4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

693661:ARCVE RS08945
gene id: 693661:ARCVE_RS08945
uniprot id: F2KQY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

693661:ARCVE RS01025
gene id: 693661:ARCVE_RS01025
uniprot id: F2KNL9
names: Similarity
messages: Belongs to the UPF0175 family.

693661:ARCVE RS08140
gene id: 693661:ARCVE_RS08140
uniprot id: F2KQ36
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

693661:ARCVE RS06100
gene id: 693661:ARCVE_RS06100
uniprot id: F2KMN5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

693661:ARCVE RS03370
gene id: 693661:ARCVE_RS03370
uniprot id: F2KR69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS08690
gene id: 693661:ARCVE_RS08690
uniprot id: F2KQL1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

693661:ARCVE RS01800
gene id: 693661:ARCVE_RS01800
uniprot id: F2KPG5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS04005
gene id: 693661:ARCVE_RS04005
uniprot id: F2KRZ0
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10545
gene id: 693661:ARCVE_RS10545
uniprot id: F2KSP0
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

693661:ARCVE RS07215
gene id: 693661:ARCVE_RS07215
uniprot id: F2KNX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

693661:ARCVE RS06705
gene id: 693661:ARCVE_RS06705
uniprot id: F2KNE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

693661:ARCVE RS00900
gene id: 693661:ARCVE_RS00900
uniprot id: F2KNJ6
names: Similarity
messages: Belongs to the UPF0147 family.

693661:ARCVE RS08035
gene id: 693661:ARCVE_RS08035
uniprot id: F2KQ15
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

693661:ARCVE RS10140
gene id: 693661:ARCVE_RS10140
uniprot id: F2KS88
names: Similarity
messages: Belongs to the TrpC family.

693661:ARCVE RS08160
gene id: 693661:ARCVE_RS08160
uniprot id: F2KQ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

693661:ARCVE RS00790
gene id: 693661:ARCVE_RS00790
uniprot id: F2KNA1
names: Similarity
messages: Belongs to the HupF/HypC family.

693661:ARCVE RS07635
gene id: 693661:ARCVE_RS07635
uniprot id: F2KPL2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02950
gene id: 693661:ARCVE_RS02950
uniprot id: F2KQQ7
names: Similarity
messages: Belongs to the MEMO1 family.

693661:ARCVE RS05065
gene id: 693661:ARCVE_RS05065
uniprot id: F2KT01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

693661:ARCVE RS00870
gene id: 693661:ARCVE_RS00870
uniprot id: F2KNJ0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

693661:ARCVE RS04275
gene id: 693661:ARCVE_RS04275
uniprot id: F2KSB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

693661:ARCVE RS07180
gene id: 693661:ARCVE_RS07180
uniprot id: F2KNW8
names: Similarity
messages: Belongs to the class-I fumarase family.

693661:ARCVE RS00850
gene id: 693661:ARCVE_RS00850
uniprot id: F2KNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

693661:ARCVE RS01600
gene id: 693661:ARCVE_RS01600
uniprot id: F2KP50
names: Similarity
messages: Belongs to the glutaredoxin family.

693661:ARCVE RS04760
gene id: 693661:ARCVE_RS04760
uniprot id: F2KSS7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS00800
gene id: 693661:ARCVE_RS00800
uniprot id: F2KNA3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09660
gene id: 693661:ARCVE_RS09660
uniprot id: F2KRS1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10530
gene id: 693661:ARCVE_RS10530
uniprot id: F2KSN7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

693661:ARCVE RS01170
gene id: 693661:ARCVE_RS01170
uniprot id: F2KNP6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

693661:ARCVE RS01805
gene id: 693661:ARCVE_RS01805
uniprot id: F2KPG6
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

693661:ARCVE RS02355
gene id: 693661:ARCVE_RS02355
uniprot id: F2KPZ9
names: Similarity
messages: Belongs to the UPF0175 family.

693661:ARCVE RS02740
gene id: 693661:ARCVE_RS02740
uniprot id: F2KQE6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

693661:ARCVE RS04850
gene id: 693661:ARCVE_RS04850
uniprot id: F2KSU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS01035
gene id: 693661:ARCVE_RS01035
uniprot id: F2KNM1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

693661:ARCVE RS08405
gene id: 693661:ARCVE_RS08405
uniprot id: F2KQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

693661:ARCVE RS08530
gene id: 693661:ARCVE_RS08530
uniprot id: F2KQI3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

693661:ARCVE RS06285
gene id: 693661:ARCVE_RS06285
uniprot id: F2KMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

693661:ARCVE RS04165
gene id: 693661:ARCVE_RS04165
uniprot id: F2KS21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

693661:ARCVE RS09990
gene id: 693661:ARCVE_RS09990
uniprot id: F2KS61
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02520
gene id: 693661:ARCVE_RS02520
uniprot id: F2KQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

693661:ARCVE RS06455
gene id: 693661:ARCVE_RS06455
uniprot id: F2KN25
names: Similarity
messages: Belongs to the glutamate synthase family.

693661:ARCVE RS01045
gene id: 693661:ARCVE_RS01045
uniprot id: F2KNM3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

693661:ARCVE RS05200
gene id: 693661:ARCVE_RS05200
uniprot id: F2KT27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

693661:ARCVE RS03900
gene id: 693661:ARCVE_RS03900
uniprot id: F2KRW9
names: Similarity
messages: Belongs to the thiolase-like superfamily. FabH family.

693661:ARCVE RS07995
gene id: 693661:ARCVE_RS07995
uniprot id: F2KQ07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

693661:ARCVE RS01130
gene id: 693661:ARCVE_RS01130
uniprot id: F2KNN8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

693661:ARCVE RS09430
gene id: 693661:ARCVE_RS09430
uniprot id: F2KRF4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

693661:ARCVE RS07740
gene id: 693661:ARCVE_RS07740
uniprot id: F2KPN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

693661:ARCVE RS04770
gene id: 693661:ARCVE_RS04770
uniprot id: F2KSS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS01900
gene id: 693661:ARCVE_RS01900
uniprot id: F2KPI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

693661:ARCVE RS03655
gene id: 693661:ARCVE_RS03655
uniprot id: F2KRJ6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

693661:ARCVE RS07955
gene id: 693661:ARCVE_RS07955
uniprot id: F2KPS4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

693661:ARCVE RS09670
gene id: 693661:ARCVE_RS09670
uniprot id: F2KRS3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

693661:ARCVE RS09505
gene id: 693661:ARCVE_RS09505
uniprot id: F2KRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

693661:ARCVE RS08910
gene id: 693661:ARCVE_RS08910
uniprot id: F2KQY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

693661:ARCVE RS05230
gene id: 693661:ARCVE_RS05230
uniprot id: F2KT33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

693661:ARCVE RS04010
gene id: 693661:ARCVE_RS04010
uniprot id: F2KRZ1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04800
gene id: 693661:ARCVE_RS04800
uniprot id: F2KST5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

693661:ARCVE RS08475
gene id: 693661:ARCVE_RS08475
uniprot id: F2KQH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS02610
gene id: 693661:ARCVE_RS02610
uniprot id: F2KQC1
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

693661:ARCVE RS09955
gene id: 693661:ARCVE_RS09955
uniprot id: F2KS54
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

693661:ARCVE RS06110
gene id: 693661:ARCVE_RS06110
uniprot id: F2KMN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

693661:ARCVE RS02485
gene id: 693661:ARCVE_RS02485
uniprot id: F2KQ96
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

693661:ARCVE RS06140
gene id: 693661:ARCVE_RS06140
uniprot id: F2KMP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

693661:ARCVE RS03395
gene id: 693661:ARCVE_RS03395
uniprot id: F2KR74
names: Similarity
messages: Belongs to the P(II) protein family.

693661:ARCVE RS06750
gene id: 693661:ARCVE_RS06750
uniprot id: F2KNF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS05795
gene id: 693661:ARCVE_RS05795
uniprot id: F2KMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS08765
gene id: 693661:ARCVE_RS08765
uniprot id: F2KQV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

693661:ARCVE RS03840
gene id: 693661:ARCVE_RS03840
uniprot id: F2KRN3
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS00970
gene id: 693661:ARCVE_RS00970
uniprot id: F2KNK9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS07690
gene id: 693661:ARCVE_RS07690
uniprot id: F2KPM3
names: Similarity
messages: Belongs to the UPF0284 family.

693661:ARCVE RS05850
gene id: 693661:ARCVE_RS05850
uniprot id: F2KMI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

693661:ARCVE RS01720
gene id: 693661:ARCVE_RS01720
uniprot id: F2KPE9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

693661:ARCVE RS10080
gene id: 693661:ARCVE_RS10080
uniprot id: F2KS78
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Belongs to the UPF0201 family.

693661:ARCVE RS08390
gene id: 693661:ARCVE_RS08390
uniprot id: F2KQF5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS06645
gene id: 693661:ARCVE_RS06645
uniprot id: F2KND6
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04570
gene id: 693661:ARCVE_RS04570
uniprot id: F2KSG9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05650
gene id: 693661:ARCVE_RS05650
uniprot id: F2KTB2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

693661:ARCVE RS10555
gene id: 693661:ARCVE_RS10555
uniprot id: F2KSP2
names: Similarity
messages: Belongs to the SUI1 family.

693661:ARCVE RS06160
gene id: 693661:ARCVE_RS06160
uniprot id: F2KMW7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

693661:ARCVE RS08550
gene id: 693661:ARCVE_RS08550
uniprot id: F2KQI7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

693661:ARCVE RS04100
gene id: 693661:ARCVE_RS04100
uniprot id: F2KS08
names: Similarity
messages: Belongs to the peptidase S8 family.

693661:ARCVE RS07630
gene id: 693661:ARCVE_RS07630
uniprot id: F2KPL1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

693661:ARCVE RS02365
gene id: 693661:ARCVE_RS02365
uniprot id: F2KQ01
names: Similarity
messages: Belongs to the acylphosphatase family.

693661:ARCVE RS03970
gene id: 693661:ARCVE_RS03970
uniprot id: F2KRY4
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

693661:ARCVE RS01785
gene id: 693661:ARCVE_RS01785
uniprot id: F2KPG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

693661:ARCVE RS02370
gene id: 693661:ARCVE_RS02370
uniprot id: F2KQ02
names: Similarity
messages: Belongs to the acylphosphatase family.

693661:ARCVE RS07840
gene id: 693661:ARCVE_RS07840
uniprot id: F2KPQ2
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS03775
gene id: 693661:ARCVE_RS03775
uniprot id: F2KRL9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

693661:ARCVE RS07320
gene id: 693661:ARCVE_RS07320
uniprot id: F2KP69
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10525
gene id: 693661:ARCVE_RS10525
uniprot id: F2KSN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

693661:ARCVE RS04685
gene id: 693661:ARCVE_RS04685
uniprot id: F2KSR2
names: Similarity
messages: Belongs to the intimin/invasin family.

693661:ARCVE RS05825
gene id: 693661:ARCVE_RS05825
uniprot id: F2KMH9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09350
gene id: 693661:ARCVE_RS09350
uniprot id: F2KRD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

693661:ARCVE RS00940
gene id: 693661:ARCVE_RS00940
uniprot id: F2KNK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

693661:ARCVE RS05375
gene id: 693661:ARCVE_RS05375
uniprot id: F2KT61
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04855
gene id: 693661:ARCVE_RS04855
uniprot id: F2KSU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

693661:ARCVE RS05135
gene id: 693661:ARCVE_RS05135
uniprot id: F2KT14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

693661:ARCVE RS06810
gene id: 693661:ARCVE_RS06810
uniprot id: F2KNG8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

693661:ARCVE RS02280
gene id: 693661:ARCVE_RS02280
uniprot id: F2KPY5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

693661:ARCVE RS06360
gene id: 693661:ARCVE_RS06360
uniprot id: F2KN05
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

693661:ARCVE RS02905
gene id: 693661:ARCVE_RS02905
uniprot id: F2KQP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

693661:ARCVE RS05470
gene id: 693661:ARCVE_RS05470
uniprot id: F2KT78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS09515
gene id: 693661:ARCVE_RS09515
uniprot id: F2KRP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS04810
gene id: 693661:ARCVE_RS04810
uniprot id: F2KST7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

693661:ARCVE RS09935
gene id: 693661:ARCVE_RS09935
uniprot id: F2KS50
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS06905
gene id: 693661:ARCVE_RS06905
uniprot id: F2KNR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

693661:ARCVE RS10135
gene id: 693661:ARCVE_RS10135
uniprot id: F2KS87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS05125
gene id: 693661:ARCVE_RS05125
uniprot id: F2KT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

693661:ARCVE RS08290
gene id: 693661:ARCVE_RS08290
uniprot id: F2KQ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

693661:ARCVE RS09345
gene id: 693661:ARCVE_RS09345
uniprot id: F2KRD7
names: Similarity
messages: Belongs to the peptidase M24B family.

693661:ARCVE RS07605
gene id: 693661:ARCVE_RS07605
uniprot id: F2KPK6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

693661:ARCVE RS10410
gene id: 693661:ARCVE_RS10410
uniprot id: F2KSL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

693661:ARCVE RS04765
gene id: 693661:ARCVE_RS04765
uniprot id: F2KSS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

693661:ARCVE RS07020
gene id: 693661:ARCVE_RS07020
uniprot id: F2KNT5
names: Similarity
messages: Belongs to the TlyA family.

693661:ARCVE RS05875
gene id: 693661:ARCVE_RS05875
uniprot id: F2KMJ0
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS03715
gene id: 693661:ARCVE_RS03715
uniprot id: F2KRK7
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS04375
gene id: 693661:ARCVE_RS04375
uniprot id: F2KSD2
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04170
gene id: 693661:ARCVE_RS04170
uniprot id: F2KS22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

693661:ARCVE RS04825
gene id: 693661:ARCVE_RS04825
uniprot id: F2KSU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS02860
gene id: 693661:ARCVE_RS02860
uniprot id: F2KQN9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

693661:ARCVE RS04775
gene id: 693661:ARCVE_RS04775
uniprot id: F2KST0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

693661:ARCVE RS00635
gene id: 693661:ARCVE_RS00635
uniprot id: F2KN68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS04595
gene id: 693661:ARCVE_RS04595
uniprot id: F2KSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

693661:ARCVE RS10055
gene id: 693661:ARCVE_RS10055
uniprot id: F2KS74
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07890
gene id: 693661:ARCVE_RS07890
uniprot id: F2KPR2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

693661:ARCVE RS01940
gene id: 693661:ARCVE_RS01940
uniprot id: F2KPJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS01185
gene id: 693661:ARCVE_RS01185
uniprot id: F2KNP9
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02540
gene id: 693661:ARCVE_RS02540
uniprot id: F2KQA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

693661:ARCVE RS08420
gene id: 693661:ARCVE_RS08420
uniprot id: F2KQG1
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07565
gene id: 693661:ARCVE_RS07565
uniprot id: F2KPC1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

693661:ARCVE RS03090
gene id: 693661:ARCVE_RS03090
uniprot id: F2KQT3
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

693661:ARCVE RS01850
gene id: 693661:ARCVE_RS01850
uniprot id: F2KPH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

693661:ARCVE RS09475
gene id: 693661:ARCVE_RS09475
uniprot id: F2KRG3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

693661:ARCVE RS02140
gene id: 693661:ARCVE_RS02140
uniprot id: F2KPV6
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

693661:ARCVE RS10115
gene id: 693661:ARCVE_RS10115
uniprot id: F2KS83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

693661:ARCVE RS02970
gene id: 693661:ARCVE_RS02970
uniprot id: F2KQR1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

693661:ARCVE RS07830
gene id: 693661:ARCVE_RS07830
uniprot id: F2KPP9
names: Similarity
messages: Belongs to the UPF0173 family.

693661:ARCVE RS03660
gene id: 693661:ARCVE_RS03660
uniprot id: F2KRJ7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

693661:ARCVE RS01290
gene id: 693661:ARCVE_RS01290
uniprot id: F2KNY9
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10030
gene id: 693661:ARCVE_RS10030
uniprot id: F2KS69
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

693661:ARCVE RS05765
gene id: 693661:ARCVE_RS05765
uniprot id: F2KTD5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

693661:ARCVE RS04820
gene id: 693661:ARCVE_RS04820
uniprot id: F2KST9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

693661:ARCVE RS07580
gene id: 693661:ARCVE_RS07580
uniprot id: F2KPC4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

693661:ARCVE RS00690
gene id: 693661:ARCVE_RS00690
uniprot id: F2KN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

693661:ARCVE RS00510
gene id: 693661:ARCVE_RS00510
uniprot id: F2KN42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

693661:ARCVE RS03850
gene id: 693661:ARCVE_RS03850
uniprot id: F2KRN5
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

693661:ARCVE RS08495
gene id: 693661:ARCVE_RS08495
uniprot id: F2KQH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

693661:ARCVE RS00585
gene id: 693661:ARCVE_RS00585
uniprot id: F2KN57
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

693661:ARCVE RS09445
gene id: 693661:ARCVE_RS09445
uniprot id: F2KRF7
names: Similarity
messages: Belongs to the HsdR family.

693661:ARCVE RS02000
gene id: 693661:ARCVE_RS02000
uniprot id: F2KPK5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

693661:ARCVE RS06390
gene id: 693661:ARCVE_RS06390
uniprot id: F2KN11
names: Similarity
messages: Belongs to the ZPR1 family.

693661:ARCVE RS08615
gene id: 693661:ARCVE_RS08615
uniprot id: F2KQJ8
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS01270
gene id: 693661:ARCVE_RS01270
uniprot id: F2KNY5
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS10190
gene id: 693661:ARCVE_RS10190
uniprot id: F2KS97
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

693661:ARCVE RS06625
gene id: 693661:ARCVE_RS06625
uniprot id: F2KND1
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

693661:ARCVE RS09200
gene id: 693661:ARCVE_RS09200
uniprot id: F2KRB1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

693661:ARCVE RS09850
gene id: 693661:ARCVE_RS09850
uniprot id: F2KRV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS06025
gene id: 693661:ARCVE_RS06025
uniprot id: F2KMM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02930
gene id: 693661:ARCVE_RS02930
uniprot id: F2KQQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

693661:ARCVE RS06975
gene id: 693661:ARCVE_RS06975
uniprot id: F2KNS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

693661:ARCVE RS04150
gene id: 693661:ARCVE_RS04150
uniprot id: F2KS18
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

693661:ARCVE RS02545
gene id: 693661:ARCVE_RS02545
uniprot id: F2KQA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

693661:ARCVE RS05940
gene id: 693661:ARCVE_RS05940
uniprot id: F2KMK2
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

693661:ARCVE RS05775
gene id: 693661:ARCVE_RS05775
uniprot id: F2KMH0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

693661:ARCVE RS01880
gene id: 693661:ARCVE_RS01880
uniprot id: F2KPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

693661:ARCVE RS08510
gene id: 693661:ARCVE_RS08510
uniprot id: F2KQH9
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS07510
gene id: 693661:ARCVE_RS07510
uniprot id: F2KPA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

693661:ARCVE RS06745
gene id: 693661:ARCVE_RS06745
uniprot id: F2KNF6
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS01825
gene id: 693661:ARCVE_RS01825
uniprot id: F2KPH0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

693661:ARCVE RS06735
gene id: 693661:ARCVE_RS06735
uniprot id: F2KNF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

693661:ARCVE RS01535
gene id: 693661:ARCVE_RS01535
uniprot id: F2KP36
names: Subcellular Location Annotation
messages: Membrane

693661:ARCVE RS05510
gene id: 693661:ARCVE_RS05510
uniprot id: F2KT87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

693661:ARCVE RS06310
gene id: 693661:ARCVE_RS06310
uniprot id: F2KMZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

693661:ARCVE RS01015
gene id: 693661:ARCVE_RS01015
uniprot id: F2KNL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

693661:ARCVE RS05140
gene id: 693661:ARCVE_RS05140
uniprot id: F2KT15
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

693661:ARCVE RS07385
gene id: 693661:ARCVE_RS07385
uniprot id: F2KP82
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.