679926:MPET RS04300
gene id: 679926:MPET_RS04300
uniprot id: E1RJ96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS04790
gene id: 679926:MPET_RS04790
uniprot id: E1RJQ8
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

679926:MPET RS13620
gene id: 679926:MPET_RS13620
uniprot id: E1RGC7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06225
gene id: 679926:MPET_RS06225
uniprot id: E1RDN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679926:MPET RS14615
gene id: 679926:MPET_RS14615
uniprot id: E1RDA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS11420
gene id: 679926:MPET_RS11420
uniprot id: E1RKS3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

679926:MPET RS13920
gene id: 679926:MPET_RS13920
uniprot id: E1RGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS03100
gene id: 679926:MPET_RS03100
uniprot id: E1RI00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

679926:MPET RS05425
gene id: 679926:MPET_RS05425
uniprot id: E1RKH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

679926:MPET RS08040
gene id: 679926:MPET_RS08040
uniprot id: E1RGP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

679926:MPET RS10825
gene id: 679926:MPET_RS10825
uniprot id: E1RK81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS07480
gene id: 679926:MPET_RS07480
uniprot id: E1RFK4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01405
gene id: 679926:MPET_RS01405
uniprot id: E1RFA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

679926:MPET RS00400
gene id: 679926:MPET_RS00400
uniprot id: E1RDH6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

679926:MPET RS09380
gene id: 679926:MPET_RS09380
uniprot id: E1RIL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

679926:MPET RS03210
gene id: 679926:MPET_RS03210
uniprot id: E1RI23
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS05595
gene id: 679926:MPET_RS05595
uniprot id: E1RKK6
names: Similarity
messages: Belongs to the malic enzymes family.

679926:MPET RS09600
gene id: 679926:MPET_RS09600
uniprot id: E1RIQ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

679926:MPET RS09625
gene id: 679926:MPET_RS09625
uniprot id: E1RIR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS09720
gene id: 679926:MPET_RS09720
uniprot id: E1RJ05
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

679926:MPET RS11025
gene id: 679926:MPET_RS11025
uniprot id: E1RKB9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS05275
gene id: 679926:MPET_RS05275
uniprot id: E1RKE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

679926:MPET RS09490
gene id: 679926:MPET_RS09490
uniprot id: E1RIN7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12595
gene id: 679926:MPET_RS12595
uniprot id: E1REZ5
names: Similarity
messages: Belongs to the peptidase M3 family.

679926:MPET RS03625
gene id: 679926:MPET_RS03625
uniprot id: E1RIH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

679926:MPET RS07685
gene id: 679926:MPET_RS07685
uniprot id: E1RG37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS11325
gene id: 679926:MPET_RS11325
uniprot id: E1RKQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS03230
gene id: 679926:MPET_RS03230
uniprot id: E1RI27
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

679926:MPET RS05475
gene id: 679926:MPET_RS05475
uniprot id: E1RKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

679926:MPET RS03490
gene id: 679926:MPET_RS03490
uniprot id: E1RIF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

679926:MPET RS01575
gene id: 679926:MPET_RS01575
uniprot id: E1RFT5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS11900
gene id: 679926:MPET_RS11900
uniprot id: E1RDR9
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

679926:MPET RS03135
gene id: 679926:MPET_RS03135
uniprot id: E1RI07
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13650
gene id: 679926:MPET_RS13650
uniprot id: E1RGD3
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

679926:MPET RS00570
gene id: 679926:MPET_RS00570
uniprot id: E1RE02
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

679926:MPET RS11760
gene id: 679926:MPET_RS11760
uniprot id: E1RDA1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

679926:MPET RS06265
gene id: 679926:MPET_RS06265
uniprot id: E1RDP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

679926:MPET RS12180
gene id: 679926:MPET_RS12180
uniprot id: E1RDX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS10740
gene id: 679926:MPET_RS10740
uniprot id: E1RJZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

679926:MPET RS07970
gene id: 679926:MPET_RS07970
uniprot id: E1RGN4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02080
gene id: 679926:MPET_RS02080
uniprot id: E1RGH3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS08935
gene id: 679926:MPET_RS08935
uniprot id: E1RHY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

679926:MPET RS08540
gene id: 679926:MPET_RS08540
uniprot id: E1RHD6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS10345
gene id: 679926:MPET_RS10345
uniprot id: E1RJJ1
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03570
gene id: 679926:MPET_RS03570
uniprot id: E1RIG8
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

679926:MPET RS10775
gene id: 679926:MPET_RS10775
uniprot id: E1RK72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

679926:MPET RS09605
gene id: 679926:MPET_RS09605
uniprot id: E1RIR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS03955
gene id: 679926:MPET_RS03955
uniprot id: E1RIW2
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

679926:MPET RS09695
gene id: 679926:MPET_RS09695
uniprot id: E1RJ00
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

679926:MPET RS10510
gene id: 679926:MPET_RS10510
uniprot id: E1RJU8
names: Similarity
messages: Belongs to the AAA ATPase family.

679926:MPET RS01990
gene id: 679926:MPET_RS01990
uniprot id: E1RGF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

679926:MPET RS09120
gene id: 679926:MPET_RS09120
uniprot id: E1RI91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

679926:MPET RS00345
gene id: 679926:MPET_RS00345
uniprot id: E1RDG5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

679926:MPET RS04570
gene id: 679926:MPET_RS04570
uniprot id: E1RJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS00410
gene id: 679926:MPET_RS00410
uniprot id: E1RDH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

679926:MPET RS08965
gene id: 679926:MPET_RS08965
uniprot id: E1RI59
names: Similarity
messages: Belongs to the eIF-2-alpha family.

679926:MPET RS10155
gene id: 679926:MPET_RS10155
uniprot id: E1RJF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

679926:MPET RS02635
gene id: 679926:MPET_RS02635
uniprot id: E1RHI4
names: Subcellular Location Annotation
messages: Cytoplasm

679926:MPET RS08510
gene id: 679926:MPET_RS08510
uniprot id: E1RHC9
names: Similarity
messages: Belongs to the HsdR family.

679926:MPET RS01775
gene id: 679926:MPET_RS01775
uniprot id: E1RFX4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

679926:MPET RS00355
gene id: 679926:MPET_RS00355
uniprot id: E1RDG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

679926:MPET RS04510
gene id: 679926:MPET_RS04510
uniprot id: E1RJK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS04170
gene id: 679926:MPET_RS04170
uniprot id: E1RJ73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679926:MPET RS09715
gene id: 679926:MPET_RS09715
uniprot id: E1RJ04
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

679926:MPET RS08770
gene id: 679926:MPET_RS08770
uniprot id: E1RHV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS02090
gene id: 679926:MPET_RS02090
uniprot id: E1RGH5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

679926:MPET RS11995
gene id: 679926:MPET_RS11995
uniprot id: E1RDT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS08960
gene id: 679926:MPET_RS08960
uniprot id: E1RI58
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

679926:MPET RS03395
gene id: 679926:MPET_RS03395
uniprot id: E1RID2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

679926:MPET RS01305
gene id: 679926:MPET_RS01305
uniprot id: E1RF88
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

679926:MPET RS11535
gene id: 679926:MPET_RS11535
uniprot id: E1RD52
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

679926:MPET RS08075
gene id: 679926:MPET_RS08075
uniprot id: E1RGQ5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS11530
gene id: 679926:MPET_RS11530
uniprot id: E1RD51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

679926:MPET RS12105
gene id: 679926:MPET_RS12105
uniprot id: E1RDW1
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

679926:MPET RS04730
gene id: 679926:MPET_RS04730
uniprot id: E1RJP7
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

679926:MPET RS12360
gene id: 679926:MPET_RS12360
uniprot id: E1REF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS01035
gene id: 679926:MPET_RS01035
uniprot id: E1REN3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

679926:MPET RS02510
gene id: 679926:MPET_RS02510
uniprot id: E1RH45
names: Similarity
messages: Belongs to the UPF0111 family.

679926:MPET RS13745
gene id: 679926:MPET_RS13745
uniprot id: E1RGT7
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

679926:MPET RS05140
gene id: 679926:MPET_RS05140
uniprot id: E1RK47
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

679926:MPET RS12530
gene id: 679926:MPET_RS12530
uniprot id: E1REI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

679926:MPET RS07535
gene id: 679926:MPET_RS07535
uniprot id: E1RG09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS11080
gene id: 679926:MPET_RS11080
uniprot id: E1RKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679926:MPET RS09395
gene id: 679926:MPET_RS09395
uniprot id: E1RIL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

679926:MPET RS11045
gene id: 679926:MPET_RS11045
uniprot id: E1RKC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS10190
gene id: 679926:MPET_RS10190
uniprot id: E1RJG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679926:MPET RS00480
gene id: 679926:MPET_RS00480
uniprot id: E1RDY5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

679926:MPET RS06435
gene id: 679926:MPET_RS06435
uniprot id: E1RE65
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

679926:MPET RS06730
gene id: 679926:MPET_RS06730
uniprot id: E1REC4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

679926:MPET RS02050
gene id: 679926:MPET_RS02050
uniprot id: E1RGG7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS00560
gene id: 679926:MPET_RS00560
uniprot id: E1RE00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

679926:MPET RS09770
gene id: 679926:MPET_RS09770
uniprot id: E1RJ15
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

679926:MPET RS02990
gene id: 679926:MPET_RS02990
uniprot id: E1RHQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

679926:MPET RS02640
gene id: 679926:MPET_RS02640
uniprot id: E1RHI5
names: Subcellular Location Annotation
messages: Cytoplasm

679926:MPET RS03590
gene id: 679926:MPET_RS03590
uniprot id: E1RIH2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08610
gene id: 679926:MPET_RS08610
uniprot id: E1RHR6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

679926:MPET RS04665
gene id: 679926:MPET_RS04665
uniprot id: E1RJN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

679926:MPET RS14120
gene id: 679926:MPET_RS14120
uniprot id: E1RHF8
names: Similarity
messages: Belongs to the DNA photolyase family.

679926:MPET RS01715
gene id: 679926:MPET_RS01715
uniprot id: E1RFW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS00360
gene id: 679926:MPET_RS00360
uniprot id: E1RDG8
names: Similarity
messages: Belongs to the UPRTase family.

679926:MPET RS08135
gene id: 679926:MPET_RS08135
uniprot id: E1RGR7
names: Similarity
messages: Belongs to the UPF0280 family.

679926:MPET RS10335
gene id: 679926:MPET_RS10335
uniprot id: E1RJI9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02815
gene id: 679926:MPET_RS02815
uniprot id: E1RHM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

679926:MPET RS06505
gene id: 679926:MPET_RS06505
uniprot id: E1RE79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

679926:MPET RS00110
gene id: 679926:MPET_RS00110
uniprot id: E1RDB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS02840
gene id: 679926:MPET_RS02840
uniprot id: E1RHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

679926:MPET RS13250
gene id: 679926:MPET_RS13250
uniprot id: E1RFR5
names: Similarity
messages: Belongs to the UPF0758 family.

679926:MPET RS10360
gene id: 679926:MPET_RS10360
uniprot id: E1RJJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679926:MPET RS12475
gene id: 679926:MPET_RS12475
uniprot id: E1REH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679926:MPET RS14560
gene id: 679926:MPET_RS14560
uniprot id: E1RJ43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS12510
gene id: 679926:MPET_RS12510
uniprot id: E1REH3
names: Similarity
messages: Belongs to the HdrB family.

679926:MPET RS11660
gene id: 679926:MPET_RS11660
uniprot id: E1RD77
names: Similarity
messages: Belongs to the HerA family.

679926:MPET RS02055
gene id: 679926:MPET_RS02055
uniprot id: E1RGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS00330
gene id: 679926:MPET_RS00330
uniprot id: E1RDG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

679926:MPET RS11895
gene id: 679926:MPET_RS11895
uniprot id: E1RDR8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

679926:MPET RS10285
gene id: 679926:MPET_RS10285
uniprot id: E1RJH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

679926:MPET RS01070
gene id: 679926:MPET_RS01070
uniprot id: E1REP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

679926:MPET RS10095
gene id: 679926:MPET_RS10095
uniprot id: E1RJE2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

679926:MPET RS13190
gene id: 679926:MPET_RS13190
uniprot id: E1RFQ3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03600
gene id: 679926:MPET_RS03600
uniprot id: E1RIH4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

679926:MPET RS05385
gene id: 679926:MPET_RS05385
uniprot id: E1RKG4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00965
gene id: 679926:MPET_RS00965
uniprot id: E1REM0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

679926:MPET RS04915
gene id: 679926:MPET_RS04915
uniprot id: E1RK07
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

679926:MPET RS10730
gene id: 679926:MPET_RS10730
uniprot id: E1RJZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

679926:MPET RS09755
gene id: 679926:MPET_RS09755
uniprot id: E1RJ12
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

679926:MPET RS03160
gene id: 679926:MPET_RS03160
uniprot id: E1RI13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS11120
gene id: 679926:MPET_RS11120
uniprot id: E1RKD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

679926:MPET RS11040
gene id: 679926:MPET_RS11040
uniprot id: E1RKC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

679926:MPET RS01195
gene id: 679926:MPET_RS01195
uniprot id: E1RER6
names: Similarity
messages: Belongs to the AAA ATPase family.

679926:MPET RS12080
gene id: 679926:MPET_RS12080
uniprot id: E1RDV5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

679926:MPET RS04705
gene id: 679926:MPET_RS04705
uniprot id: E1RJP3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

679926:MPET RS05365
gene id: 679926:MPET_RS05365
uniprot id: E1RKG0
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

679926:MPET RS11330
gene id: 679926:MPET_RS11330
uniprot id: E1RKQ5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10680
gene id: 679926:MPET_RS10680
uniprot id: E1RJY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

679926:MPET RS10615
gene id: 679926:MPET_RS10615
uniprot id: E1RJW9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

679926:MPET RS03880
gene id: 679926:MPET_RS03880
uniprot id: E1RIU9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

679926:MPET RS03835
gene id: 679926:MPET_RS03835
uniprot id: E1RIU0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

679926:MPET RS09405
gene id: 679926:MPET_RS09405
uniprot id: E1RIM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

679926:MPET RS03810
gene id: 679926:MPET_RS03810
uniprot id: E1RIT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

679926:MPET RS11060
gene id: 679926:MPET_RS11060
uniprot id: E1RKC7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

679926:MPET RS14025
gene id: 679926:MPET_RS14025
uniprot id: E1RGZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

679926:MPET RS03070
gene id: 679926:MPET_RS03070
uniprot id: E1RHZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

679926:MPET RS08080
gene id: 679926:MPET_RS08080
uniprot id: E1RGQ6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12155
gene id: 679926:MPET_RS12155
uniprot id: E1RDW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS04920
gene id: 679926:MPET_RS04920
uniprot id: E1RK08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

679926:MPET RS06295
gene id: 679926:MPET_RS06295
uniprot id: E1RDP7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679926:MPET RS10595
gene id: 679926:MPET_RS10595
uniprot id: E1RJW5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

679926:MPET RS12190
gene id: 679926:MPET_RS12190
uniprot id: E1RDX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS01565
gene id: 679926:MPET_RS01565
uniprot id: E1RFT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS10065
gene id: 679926:MPET_RS10065
uniprot id: E1RJD6
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS11905
gene id: 679926:MPET_RS11905
uniprot id: E1RDS0
names: Similarity
messages: Belongs to the HisA/HisF family.

679926:MPET RS03405
gene id: 679926:MPET_RS03405
uniprot id: E1RID4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

679926:MPET RS04670
gene id: 679926:MPET_RS04670
uniprot id: E1RJN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

679926:MPET RS03035
gene id: 679926:MPET_RS03035
uniprot id: E1RHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679926:MPET RS02980
gene id: 679926:MPET_RS02980
uniprot id: E1RHQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679926:MPET RS13020
gene id: 679926:MPET_RS13020
uniprot id: E1RFM0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

679926:MPET RS08165
gene id: 679926:MPET_RS08165
uniprot id: E1RGS3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

679926:MPET RS11550
gene id: 679926:MPET_RS11550
uniprot id: E1RD55
names: Subcellular Location Annotation
messages: Cell membrane

679926:MPET RS02895
gene id: 679926:MPET_RS02895
uniprot id: E1RHN6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

679926:MPET RS00555
gene id: 679926:MPET_RS00555
uniprot id: E1RDZ9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00845
gene id: 679926:MPET_RS00845
uniprot id: E1REJ6
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

679926:MPET RS12335
gene id: 679926:MPET_RS12335
uniprot id: E1REE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

679926:MPET RS08155
gene id: 679926:MPET_RS08155
uniprot id: E1RGS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

679926:MPET RS00425
gene id: 679926:MPET_RS00425
uniprot id: E1RDI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

679926:MPET RS12480
gene id: 679926:MPET_RS12480
uniprot id: E1REH3
names: Similarity
messages: Belongs to the HdrB family.

679926:MPET RS03565
gene id: 679926:MPET_RS03565
uniprot id: E1RIG7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

679926:MPET RS04850
gene id: 679926:MPET_RS04850
uniprot id: E1RJS0
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02475
gene id: 679926:MPET_RS02475
uniprot id: E1RH38
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS11260
gene id: 679926:MPET_RS11260
uniprot id: E1RKP1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

679926:MPET RS11030
gene id: 679926:MPET_RS11030
uniprot id: E1RKC0
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

679926:MPET RS01340
gene id: 679926:MPET_RS01340
uniprot id: E1RF95
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00455
gene id: 679926:MPET_RS00455
uniprot id: E1RDI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

679926:MPET RS06660
gene id: 679926:MPET_RS06660
uniprot id: E1REB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

679926:MPET RS11355
gene id: 679926:MPET_RS11355
uniprot id: E1RKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

679926:MPET RS03255
gene id: 679926:MPET_RS03255
uniprot id: E1RI32
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS04355
gene id: 679926:MPET_RS04355
uniprot id: E1RJA7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13075
gene id: 679926:MPET_RS13075
uniprot id: E1RFN0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

679926:MPET RS13910
gene id: 679926:MPET_RS13910
uniprot id: E1RGX0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

679926:MPET RS08435
gene id: 679926:MPET_RS08435
uniprot id: E1RHB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

679926:MPET RS03505
gene id: 679926:MPET_RS03505
uniprot id: E1RIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

679926:MPET RS07425
gene id: 679926:MPET_RS07425
uniprot id: E1RFJ3
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

679926:MPET RS01560
gene id: 679926:MPET_RS01560
uniprot id: E1RFT2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02235
gene id: 679926:MPET_RS02235
uniprot id: E1RGK4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

679926:MPET RS04795
gene id: 679926:MPET_RS04795
uniprot id: E1RJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679926:MPET RS12065
gene id: 679926:MPET_RS12065
uniprot id: E1RDV2
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

679926:MPET RS13370
gene id: 679926:MPET_RS13370
uniprot id: E1RG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

679926:MPET RS10675
gene id: 679926:MPET_RS10675
uniprot id: E1RJY1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

679926:MPET RS01470
gene id: 679926:MPET_RS01470
uniprot id: E1RFC2
names: Similarity
messages: Belongs to the DtxR/MntR family.

679926:MPET RS11440
gene id: 679926:MPET_RS11440
uniprot id: E1RKS7
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

679926:MPET RS06975
gene id: 679926:MPET_RS06975
uniprot id: E1REW3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

679926:MPET RS10140
gene id: 679926:MPET_RS10140
uniprot id: E1RJF0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS06620
gene id: 679926:MPET_RS06620
uniprot id: E1REA1
names: Similarity
messages: Belongs to the HypE family.

679926:MPET RS03830
gene id: 679926:MPET_RS03830
uniprot id: E1RIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

679926:MPET RS01605
gene id: 679926:MPET_RS01605
uniprot id: E1RFU1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

679926:MPET RS08345
gene id: 679926:MPET_RS08345
uniprot id: E1RH96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

679926:MPET RS08460
gene id: 679926:MPET_RS08460
uniprot id: E1RHB9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS00490
gene id: 679926:MPET_RS00490
uniprot id: E1RDY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

679926:MPET RS13555
gene id: 679926:MPET_RS13555
uniprot id: E1RGB4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

679926:MPET RS09430
gene id: 679926:MPET_RS09430
uniprot id: E1RIM5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

679926:MPET RS04725
gene id: 679926:MPET_RS04725
uniprot id: E1RJP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679926:MPET RS13540
gene id: 679926:MPET_RS13540
uniprot id: E1RGB3
names: Similarity
messages: Belongs to the peptidase C59 family.

679926:MPET RS12195
gene id: 679926:MPET_RS12195
uniprot id: E1RDX5
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS13315
gene id: 679926:MPET_RS13315
uniprot id: E1RFS8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03105
gene id: 679926:MPET_RS03105
uniprot id: E1RI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679926:MPET RS06840
gene id: 679926:MPET_RS06840
uniprot id: E1RET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

679926:MPET RS05510
gene id: 679926:MPET_RS05510
uniprot id: E1RKJ0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

679926:MPET RS07530
gene id: 679926:MPET_RS07530
uniprot id: E1RG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

679926:MPET RS01385
gene id: 679926:MPET_RS01385
uniprot id: E1RFA3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03960
gene id: 679926:MPET_RS03960
uniprot id: E1RIW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS07690
gene id: 679926:MPET_RS07690
uniprot id: E1RG38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS04885
gene id: 679926:MPET_RS04885
uniprot id: E1RK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679926:MPET RS08000
gene id: 679926:MPET_RS08000
uniprot id: E1RGP0
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12875
gene id: 679926:MPET_RS12875
uniprot id: E1RF52
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

679926:MPET RS01380
gene id: 679926:MPET_RS01380
uniprot id: E1RFA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

679926:MPET RS00465
gene id: 679926:MPET_RS00465
uniprot id: E1RDI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

679926:MPET RS09310
gene id: 679926:MPET_RS09310
uniprot id: E1RIC8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09055
gene id: 679926:MPET_RS09055
uniprot id: E1RI77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS06540
gene id: 679926:MPET_RS06540
uniprot id: E1RE87
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

679926:MPET RS13795
gene id: 679926:MPET_RS13795
uniprot id: E1RGU7
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

679926:MPET RS04020
gene id: 679926:MPET_RS04020
uniprot id: E1RIX5
names: Similarity
messages: Belongs to the UPF0047 family.

679926:MPET RS03455
gene id: 679926:MPET_RS03455
uniprot id: E1RIE4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

679926:MPET RS07025
gene id: 679926:MPET_RS07025
uniprot id: E1REX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

679926:MPET RS04840
gene id: 679926:MPET_RS04840
uniprot id: E1RJR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS10115
gene id: 679926:MPET_RS10115
uniprot id: E1RJE6
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

679926:MPET RS12165
gene id: 679926:MPET_RS12165
uniprot id: E1RDW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS12235
gene id: 679926:MPET_RS12235
uniprot id: E1REC7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01045
gene id: 679926:MPET_RS01045
uniprot id: E1REN5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

679926:MPET RS11050
gene id: 679926:MPET_RS11050
uniprot id: E1RKC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

679926:MPET RS00790
gene id: 679926:MPET_RS00790
uniprot id: E1RE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

679926:MPET RS15545
gene id: 679926:MPET_RS15545
uniprot id: E1RD61
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

679926:MPET RS09865
gene id: 679926:MPET_RS09865
uniprot id: E1RJ34
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

679926:MPET RS11910
gene id: 679926:MPET_RS11910
uniprot id: E1RDS1
names: Similarity
messages: Belongs to the thymidylate kinase family.

679926:MPET RS10180
gene id: 679926:MPET_RS10180
uniprot id: E1RJF8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

679926:MPET RS08805
gene id: 679926:MPET_RS08805
uniprot id: E1RHV6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

679926:MPET RS11100
gene id: 679926:MPET_RS11100
uniprot id: E1RKD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

679926:MPET RS11980
gene id: 679926:MPET_RS11980
uniprot id: E1RDT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

679926:MPET RS11405
gene id: 679926:MPET_RS11405
uniprot id: E1RKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

679926:MPET RS13235
gene id: 679926:MPET_RS13235
uniprot id: E1RFR2
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

679926:MPET RS09725
gene id: 679926:MPET_RS09725
uniprot id: E1RJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

679926:MPET RS11055
gene id: 679926:MPET_RS11055
uniprot id: E1RKC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

679926:MPET RS05345
gene id: 679926:MPET_RS05345
uniprot id: E1RKF6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01055
gene id: 679926:MPET_RS01055
uniprot id: E1REN7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

679926:MPET RS05300
gene id: 679926:MPET_RS05300
uniprot id: E1RKE7
names: Similarity
messages: Belongs to the HerA family.

679926:MPET RS06635
gene id: 679926:MPET_RS06635
uniprot id: E1REA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

679926:MPET RS13365
gene id: 679926:MPET_RS13365
uniprot id: E1RG79
names: Similarity
messages: Belongs to the aspartokinase family.

679926:MPET RS03045
gene id: 679926:MPET_RS03045
uniprot id: E1RHY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

679926:MPET RS05200
gene id: 679926:MPET_RS05200
uniprot id: E1RK57
names: Similarity
messages: Belongs to the serpin family.

679926:MPET RS06535
gene id: 679926:MPET_RS06535
uniprot id: E1RE85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

679926:MPET RS11750
gene id: 679926:MPET_RS11750
uniprot id: E1RD99
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS05055
gene id: 679926:MPET_RS05055
uniprot id: E1RK31
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS03605
gene id: 679926:MPET_RS03605
uniprot id: E1RIH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

679926:MPET RS11090
gene id: 679926:MPET_RS11090
uniprot id: E1RKD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

679926:MPET RS11540
gene id: 679926:MPET_RS11540
uniprot id: E1RD53
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

679926:MPET RS12915
gene id: 679926:MPET_RS12915
uniprot id: E1RF60
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03390
gene id: 679926:MPET_RS03390
uniprot id: E1RID1
names: Similarity
messages: Belongs to the PurH family.

679926:MPET RS05460
gene id: 679926:MPET_RS05460
uniprot id: E1RKI0
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06330
gene id: 679926:MPET_RS06330
uniprot id: E1RDQ4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

679926:MPET RS01330
gene id: 679926:MPET_RS01330
uniprot id: E1RF93
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

679926:MPET RS09745
gene id: 679926:MPET_RS09745
uniprot id: E1RJ10
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

679926:MPET RS01725
gene id: 679926:MPET_RS01725
uniprot id: E1RFW4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

679926:MPET RS08970
gene id: 679926:MPET_RS08970
uniprot id: E1RI60
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

679926:MPET RS01785
gene id: 679926:MPET_RS01785
uniprot id: E1RFX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

679926:MPET RS13625
gene id: 679926:MPET_RS13625
uniprot id: E1RGC8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

679926:MPET RS09040
gene id: 679926:MPET_RS09040
uniprot id: E1RI74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

679926:MPET RS05020
gene id: 679926:MPET_RS05020
uniprot id: E1RK24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

679926:MPET RS07545
gene id: 679926:MPET_RS07545
uniprot id: E1RG11
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

679926:MPET RS04005
gene id: 679926:MPET_RS04005
uniprot id: E1RIX2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

679926:MPET RS11480
gene id: 679926:MPET_RS11480
uniprot id: E1RKT5
names: Similarity
messages: Belongs to the class-I fumarase family.

679926:MPET RS03215
gene id: 679926:MPET_RS03215
uniprot id: E1RI24
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS05340
gene id: 679926:MPET_RS05340
uniprot id: E1RKF5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08750
gene id: 679926:MPET_RS08750
uniprot id: E1RHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

679926:MPET RS14535
gene id: 679926:MPET_RS14535
uniprot id: E1RHA5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS10530
gene id: 679926:MPET_RS10530
uniprot id: E1RJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

679926:MPET RS06785
gene id: 679926:MPET_RS06785
uniprot id: E1RES7
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

679926:MPET RS03735
gene id: 679926:MPET_RS03735
uniprot id: E1RIJ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS00055
gene id: 679926:MPET_RS00055
uniprot id: E1RCW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS08765
gene id: 679926:MPET_RS08765
uniprot id: E1RHV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS07095
gene id: 679926:MPET_RS07095
uniprot id: E1REY6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12805
gene id: 679926:MPET_RS12805
uniprot id: E1RF39
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS09925
gene id: 679926:MPET_RS09925
uniprot id: E1RJ45
names: Similarity
messages: Belongs to the UPF0111 family.

679926:MPET RS06285
gene id: 679926:MPET_RS06285
uniprot id: E1RDP6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679926:MPET RS06570
gene id: 679926:MPET_RS06570
uniprot id: E1RE92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

679926:MPET RS00950
gene id: 679926:MPET_RS00950
uniprot id: E1REL7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS00475
gene id: 679926:MPET_RS00475
uniprot id: E1RDY3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

679926:MPET RS09840
gene id: 679926:MPET_RS09840
uniprot id: E1RJ29
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02705
gene id: 679926:MPET_RS02705
uniprot id: E1RHJ9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03270
gene id: 679926:MPET_RS03270
uniprot id: E1RI35
names: Similarity
messages: Belongs to the phosphoribulokinase family.

679926:MPET RS06665
gene id: 679926:MPET_RS06665
uniprot id: E1REB1
names: Similarity
messages: Belongs to the GARS family.

679926:MPET RS11005
gene id: 679926:MPET_RS11005
uniprot id: E1RKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

679926:MPET RS06460
gene id: 679926:MPET_RS06460
uniprot id: E1RE70
names: Similarity
messages: Belongs to the glutamate synthase family.

679926:MPET RS03110
gene id: 679926:MPET_RS03110
uniprot id: E1RI02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

679926:MPET RS04520
gene id: 679926:MPET_RS04520
uniprot id: E1RJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS12965
gene id: 679926:MPET_RS12965
uniprot id: E1RFL0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

679926:MPET RS00805
gene id: 679926:MPET_RS00805
uniprot id: E1RE44
names: Similarity
messages: Belongs to the IMPACT family.

679926:MPET RS04890
gene id: 679926:MPET_RS04890
uniprot id: E1RK02
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

679926:MPET RS08560
gene id: 679926:MPET_RS08560
uniprot id: E1RHE0
names: Similarity
messages: Belongs to the UPF0215 family.

679926:MPET RS00485
gene id: 679926:MPET_RS00485
uniprot id: E1RDY6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS04685
gene id: 679926:MPET_RS04685
uniprot id: E1RJN9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS02620
gene id: 679926:MPET_RS02620
uniprot id: E1RH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS03510
gene id: 679926:MPET_RS03510
uniprot id: E1RIF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS05590
gene id: 679926:MPET_RS05590
uniprot id: E1RKK5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

679926:MPET RS10725
gene id: 679926:MPET_RS10725
uniprot id: E1RJZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

679926:MPET RS12890
gene id: 679926:MPET_RS12890
uniprot id: E1RF55
names: Similarity
messages: Belongs to the MtrH family.

679926:MPET RS09595
gene id: 679926:MPET_RS09595
uniprot id: E1RIQ8
names: Similarity
messages: Belongs to the LarC family.

679926:MPET RS14045
gene id: 679926:MPET_RS14045
uniprot id: E1RGZ7
names: Similarity
messages: Belongs to the RutC family.

679926:MPET RS09730
gene id: 679926:MPET_RS09730
uniprot id: E1RJ07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

679926:MPET RS11275
gene id: 679926:MPET_RS11275
uniprot id: E1RKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS05330
gene id: 679926:MPET_RS05330
uniprot id: E1RKF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

679926:MPET RS03370
gene id: 679926:MPET_RS03370
uniprot id: E1RI55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

679926:MPET RS01170
gene id: 679926:MPET_RS01170
uniprot id: E1RER1
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679926:MPET RS07495
gene id: 679926:MPET_RS07495
uniprot id: E1RG02
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01125
gene id: 679926:MPET_RS01125
uniprot id: E1REQ1
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03355
gene id: 679926:MPET_RS03355
uniprot id: E1RI52
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

679926:MPET RS08585
gene id: 679926:MPET_RS08585
uniprot id: E1RHR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

679926:MPET RS09390
gene id: 679926:MPET_RS09390
uniprot id: E1RIL7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

679926:MPET RS02480
gene id: 679926:MPET_RS02480
uniprot id: E1RH39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS11285
gene id: 679926:MPET_RS11285
uniprot id: E1RKP6
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

679926:MPET RS09035
gene id: 679926:MPET_RS09035
uniprot id: E1RI73
names: Similarity
messages: Belongs to the UPF0179 family.

679926:MPET RS10645
gene id: 679926:MPET_RS10645
uniprot id: E1RJX5
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

679926:MPET RS11170
gene id: 679926:MPET_RS11170
uniprot id: E1RKM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

679926:MPET RS11475
gene id: 679926:MPET_RS11475
uniprot id: E1RKT4
names: Similarity
messages: Belongs to the class-I fumarase family.

679926:MPET RS11140
gene id: 679926:MPET_RS11140
uniprot id: E1RKL7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

679926:MPET RS05305
gene id: 679926:MPET_RS05305
uniprot id: E1RKE8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09210
gene id: 679926:MPET_RS09210
uniprot id: E1RIA7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01750
gene id: 679926:MPET_RS01750
uniprot id: E1RFW9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13720
gene id: 679926:MPET_RS13720
uniprot id: E1RGT2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

679926:MPET RS11400
gene id: 679926:MPET_RS11400
uniprot id: E1RKR9
names: Similarity
messages: Belongs to the MtxX family.

679926:MPET RS08120
gene id: 679926:MPET_RS08120
uniprot id: E1RGR4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

679926:MPET RS13440
gene id: 679926:MPET_RS13440
uniprot id: E1RG93
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

679926:MPET RS12810
gene id: 679926:MPET_RS12810
uniprot id: E1RF40
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS11135
gene id: 679926:MPET_RS11135
uniprot id: E1RKL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

679926:MPET RS13010
gene id: 679926:MPET_RS13010
uniprot id: E1RFL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

679926:MPET RS02940
gene id: 679926:MPET_RS02940
uniprot id: E1RHP4
names: Similarity
messages: Belongs to the peptidase M24B family.

679926:MPET RS10350
gene id: 679926:MPET_RS10350
uniprot id: E1RJJ2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS14040
gene id: 679926:MPET_RS14040
uniprot id: E1RGZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS07735
gene id: 679926:MPET_RS07735
uniprot id: E1RG47
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

679926:MPET RS01610
gene id: 679926:MPET_RS01610
uniprot id: E1RFU2
names: Similarity
messages: Belongs to the DMRL synthase family.

679926:MPET RS01865
gene id: 679926:MPET_RS01865
uniprot id: E1RFZ2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08205
gene id: 679926:MPET_RS08205
uniprot id: E1RH72
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS06655
gene id: 679926:MPET_RS06655
uniprot id: E1REA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

679926:MPET RS09410
gene id: 679926:MPET_RS09410
uniprot id: E1RIM1
names: Similarity
messages: Belongs to the HerA family.

679926:MPET RS12565
gene id: 679926:MPET_RS12565
uniprot id: E1REJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

679926:MPET RS05570
gene id: 679926:MPET_RS05570
uniprot id: E1RKK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS09215
gene id: 679926:MPET_RS09215
uniprot id: E1RIA8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10060
gene id: 679926:MPET_RS10060
uniprot id: E1RJD5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS06315
gene id: 679926:MPET_RS06315
uniprot id: E1RDQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS03400
gene id: 679926:MPET_RS03400
uniprot id: E1RID3
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

679926:MPET RS08830
gene id: 679926:MPET_RS08830
uniprot id: E1RHW0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

679926:MPET RS08910
gene id: 679926:MPET_RS08910
uniprot id: E1RHX5
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

679926:MPET RS08630
gene id: 679926:MPET_RS08630
uniprot id: E1RHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

679926:MPET RS10500
gene id: 679926:MPET_RS10500
uniprot id: E1RJU6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

679926:MPET RS02800
gene id: 679926:MPET_RS02800
uniprot id: E1RHL7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

679926:MPET RS12005
gene id: 679926:MPET_RS12005
uniprot id: E1RDU0
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

679926:MPET RS10465
gene id: 679926:MPET_RS10465
uniprot id: E1RJT8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

679926:MPET RS03820
gene id: 679926:MPET_RS03820
uniprot id: E1RIT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS11130
gene id: 679926:MPET_RS11130
uniprot id: E1RKL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS03085
gene id: 679926:MPET_RS03085
uniprot id: E1RHZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

679926:MPET RS12000
gene id: 679926:MPET_RS12000
uniprot id: E1RDT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

679926:MPET RS11510
gene id: 679926:MPET_RS11510
uniprot id: E1RD47
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS03695
gene id: 679926:MPET_RS03695
uniprot id: E1RII9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

679926:MPET RS06350
gene id: 679926:MPET_RS06350
uniprot id: E1RDQ8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

679926:MPET RS01150
gene id: 679926:MPET_RS01150
uniprot id: E1REQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

679926:MPET RS06495
gene id: 679926:MPET_RS06495
uniprot id: E1RE77
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06525
gene id: 679926:MPET_RS06525
uniprot id: E1RE83
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

679926:MPET RS09355
gene id: 679926:MPET_RS09355
uniprot id: E1RIL0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

679926:MPET RS09425
gene id: 679926:MPET_RS09425
uniprot id: E1RIM4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

679926:MPET RS08015
gene id: 679926:MPET_RS08015
uniprot id: E1RGP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS00545
gene id: 679926:MPET_RS00545
uniprot id: E1RDZ8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

679926:MPET RS04060
gene id: 679926:MPET_RS04060
uniprot id: E1RIY3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02945
gene id: 679926:MPET_RS02945
uniprot id: E1RHP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

679926:MPET RS08975
gene id: 679926:MPET_RS08975
uniprot id: E1RI61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS07630
gene id: 679926:MPET_RS07630
uniprot id: E1RG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS00050
gene id: 679926:MPET_RS00050
uniprot id: E1RCW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

679926:MPET RS00540
gene id: 679926:MPET_RS00540
uniprot id: E1RDZ7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS05015
gene id: 679926:MPET_RS05015
uniprot id: E1RK23
names: Similarity
messages: Belongs to the MCM family.

679926:MPET RS04785
gene id: 679926:MPET_RS04785
uniprot id: E1RJQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

679926:MPET RS11445
gene id: 679926:MPET_RS11445
uniprot id: E1RKS8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

679926:MPET RS03805
gene id: 679926:MPET_RS03805
uniprot id: E1RIT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

679926:MPET RS13660
gene id: 679926:MPET_RS13660
uniprot id: E1RGD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

679926:MPET RS11385
gene id: 679926:MPET_RS11385
uniprot id: E1RKR6
names: Similarity
messages: Belongs to the UPF0146 family.

679926:MPET RS03465
gene id: 679926:MPET_RS03465
uniprot id: E1RIE6
names: Similarity
messages: Belongs to the UPF0166 family.

679926:MPET RS06090
gene id: 679926:MPET_RS06090
uniprot id: E1RDK5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06180
gene id: 679926:MPET_RS06180
uniprot id: E1RDM5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679926:MPET RS13005
gene id: 679926:MPET_RS13005
uniprot id: E1RFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

679926:MPET RS09735
gene id: 679926:MPET_RS09735
uniprot id: E1RJ08
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS08635
gene id: 679926:MPET_RS08635
uniprot id: E1RHS3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679926:MPET RS11145
gene id: 679926:MPET_RS11145
uniprot id: E1RKL8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS05195
gene id: 679926:MPET_RS05195
uniprot id: E1RK56
names: Similarity
messages: Belongs to the serpin family.

679926:MPET RS03920
gene id: 679926:MPET_RS03920
uniprot id: E1RIV6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS13165
gene id: 679926:MPET_RS13165
uniprot id: E1RFP8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

679926:MPET RS07070
gene id: 679926:MPET_RS07070
uniprot id: E1REY2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

679926:MPET RS05045
gene id: 679926:MPET_RS05045
uniprot id: E1RK29
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS04345
gene id: 679926:MPET_RS04345
uniprot id: E1RJA5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

679926:MPET RS05060
gene id: 679926:MPET_RS05060
uniprot id: E1RK32
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

679926:MPET RS09940
gene id: 679926:MPET_RS09940
uniprot id: E1RJ48
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10750
gene id: 679926:MPET_RS10750
uniprot id: E1RJZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

679926:MPET RS12850
gene id: 679926:MPET_RS12850
uniprot id: E1RF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

679926:MPET RS01020
gene id: 679926:MPET_RS01020
uniprot id: E1REN0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

679926:MPET RS01310
gene id: 679926:MPET_RS01310
uniprot id: E1RF89
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

679926:MPET RS12210
gene id: 679926:MPET_RS12210
uniprot id: E1RDX8
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS13405
gene id: 679926:MPET_RS13405
uniprot id: E1RG87
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

679926:MPET RS05895
gene id: 679926:MPET_RS05895
uniprot id: E1RD20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

679926:MPET RS04255
gene id: 679926:MPET_RS04255
uniprot id: E1RJ87
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS09465
gene id: 679926:MPET_RS09465
uniprot id: E1RIN2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09710
gene id: 679926:MPET_RS09710
uniprot id: E1RJ03
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

679926:MPET RS05010
gene id: 679926:MPET_RS05010
uniprot id: E1RK22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

679926:MPET RS12855
gene id: 679926:MPET_RS12855
uniprot id: E1RF48
names: Similarity
messages: Belongs to the P(II) protein family.

679926:MPET RS02150
gene id: 679926:MPET_RS02150
uniprot id: E1RGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

679926:MPET RS08605
gene id: 679926:MPET_RS08605
uniprot id: E1RHR5
names: Similarity
messages: Belongs to the archease family.

679926:MPET RS09220
gene id: 679926:MPET_RS09220
uniprot id: E1RIA9
names: Similarity
messages: Belongs to the SUI1 family.

679926:MPET RS08870
gene id: 679926:MPET_RS08870
uniprot id: E1RHW7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

679926:MPET RS04350
gene id: 679926:MPET_RS04350
uniprot id: E1RJA6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03555
gene id: 679926:MPET_RS03555
uniprot id: E1RIG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

679926:MPET RS11875
gene id: 679926:MPET_RS11875
uniprot id: E1RDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

679926:MPET RS01315
gene id: 679926:MPET_RS01315
uniprot id: E1RF90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

679926:MPET RS06910
gene id: 679926:MPET_RS06910
uniprot id: E1REV0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS12980
gene id: 679926:MPET_RS12980
uniprot id: E1RFL3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS05500
gene id: 679926:MPET_RS05500
uniprot id: E1RKI8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS01180
gene id: 679926:MPET_RS01180
uniprot id: E1RER3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

679926:MPET RS01175
gene id: 679926:MPET_RS01175
uniprot id: E1RER2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

679926:MPET RS03060
gene id: 679926:MPET_RS03060
uniprot id: E1RHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

679926:MPET RS06690
gene id: 679926:MPET_RS06690
uniprot id: E1REB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS14715
gene id: 679926:MPET_RS14715
uniprot id: E1RGC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS04235
gene id: 679926:MPET_RS04235
uniprot id: E1RJ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

679926:MPET RS00625
gene id: 679926:MPET_RS00625
uniprot id: E1RE12
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03825
gene id: 679926:MPET_RS03825
uniprot id: E1RIT8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

679926:MPET RS11150
gene id: 679926:MPET_RS11150
uniprot id: E1RKL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS08940
gene id: 679926:MPET_RS08940
uniprot id: E1RHY1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

679926:MPET RS01325
gene id: 679926:MPET_RS01325
uniprot id: E1RF92
names: Similarity
messages: Belongs to the P(II) protein family.

679926:MPET RS05215
gene id: 679926:MPET_RS05215
uniprot id: E1RK60
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

679926:MPET RS10420
gene id: 679926:MPET_RS10420
uniprot id: E1RJS9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

679926:MPET RS13970
gene id: 679926:MPET_RS13970
uniprot id: E1RGY2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02375
gene id: 679926:MPET_RS02375
uniprot id: E1RH18
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04080
gene id: 679926:MPET_RS04080
uniprot id: E1RIY7
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

679926:MPET RS06420
gene id: 679926:MPET_RS06420
uniprot id: E1RE62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

679926:MPET RS02380
gene id: 679926:MPET_RS02380
uniprot id: E1RH19
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12485
gene id: 679926:MPET_RS12485
uniprot id: E1REH4
names: Similarity
messages: Belongs to the HdrC family.

679926:MPET RS11770
gene id: 679926:MPET_RS11770
uniprot id: E1RDA3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06715
gene id: 679926:MPET_RS06715
uniprot id: E1REC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

679926:MPET RS10945
gene id: 679926:MPET_RS10945
uniprot id: E1RKA4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

679926:MPET RS09565
gene id: 679926:MPET_RS09565
uniprot id: E1RIQ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS01095
gene id: 679926:MPET_RS01095
uniprot id: E1REP5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

679926:MPET RS06500
gene id: 679926:MPET_RS06500
uniprot id: E1RE78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

679926:MPET RS08920
gene id: 679926:MPET_RS08920
uniprot id: E1RHX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679926:MPET RS12255
gene id: 679926:MPET_RS12255
uniprot id: E1RED1
names: Similarity
messages: Belongs to the group II decarboxylase family.

679926:MPET RS14360
gene id: 679926:MPET_RS14360
uniprot id: E1RH23
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

679926:MPET RS09460
gene id: 679926:MPET_RS09460
uniprot id: E1RIN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679926:MPET RS04845
gene id: 679926:MPET_RS04845
uniprot id: E1RJR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

679926:MPET RS00015
gene id: 679926:MPET_RS00015
uniprot id: E1RCV3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679926:MPET RS02045
gene id: 679926:MPET_RS02045
uniprot id: E1RGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS06145
gene id: 679926:MPET_RS06145
uniprot id: E1RDL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

679926:MPET RS13090
gene id: 679926:MPET_RS13090
uniprot id: E1RFN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

679926:MPET RS11195
gene id: 679926:MPET_RS11195
uniprot id: E1RKM8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10620
gene id: 679926:MPET_RS10620
uniprot id: E1RJX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

679926:MPET RS03715
gene id: 679926:MPET_RS03715
uniprot id: E1RIJ3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08590
gene id: 679926:MPET_RS08590
uniprot id: E1RHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

679926:MPET RS12250
gene id: 679926:MPET_RS12250
uniprot id: E1RED0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

679926:MPET RS14035
gene id: 679926:MPET_RS14035
uniprot id: E1RGZ5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08890
gene id: 679926:MPET_RS08890
uniprot id: E1RHX1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

679926:MPET RS14155
gene id: 679926:MPET_RS14155
uniprot id: E1RHG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS08145
gene id: 679926:MPET_RS08145
uniprot id: E1RGR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS02765
gene id: 679926:MPET_RS02765
uniprot id: E1RHL1
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

679926:MPET RS01185
gene id: 679926:MPET_RS01185
uniprot id: E1RER4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679926:MPET RS09370
gene id: 679926:MPET_RS09370
uniprot id: E1RIL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

679926:MPET RS00895
gene id: 679926:MPET_RS00895
uniprot id: E1REK7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12750
gene id: 679926:MPET_RS12750
uniprot id: E1RF27
names: Similarity
messages: Belongs to the UPF0210 family.

679926:MPET RS06610
gene id: 679926:MPET_RS06610
uniprot id: E1RE99
names: Similarity
messages: Belongs to the HupF/HypC family.

679926:MPET RS09365
gene id: 679926:MPET_RS09365
uniprot id: E1RIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

679926:MPET RS05665
gene id: 679926:MPET_RS05665
uniprot id: E1RCX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06355
gene id: 679926:MPET_RS06355
uniprot id: E1RDQ9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

679926:MPET RS02190
gene id: 679926:MPET_RS02190
uniprot id: E1RGJ5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13785
gene id: 679926:MPET_RS13785
uniprot id: E1RGU5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03850
gene id: 679926:MPET_RS03850
uniprot id: E1RIU3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

679926:MPET RS01160
gene id: 679926:MPET_RS01160
uniprot id: E1REQ9
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679926:MPET RS11870
gene id: 679926:MPET_RS11870
uniprot id: E1RDR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

679926:MPET RS03870
gene id: 679926:MPET_RS03870
uniprot id: E1RIU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS02560
gene id: 679926:MPET_RS02560
uniprot id: E1RH54
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04895
gene id: 679926:MPET_RS04895
uniprot id: E1RK03
names: Similarity
messages: Belongs to the SDO1/SBDS family.

679926:MPET RS02615
gene id: 679926:MPET_RS02615
uniprot id: E1RH65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS09540
gene id: 679926:MPET_RS09540
uniprot id: E1RIP7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS11165
gene id: 679926:MPET_RS11165
uniprot id: E1RKM2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04515
gene id: 679926:MPET_RS04515
uniprot id: E1RJK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS08375
gene id: 679926:MPET_RS08375
uniprot id: E1RHA2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

679926:MPET RS04715
gene id: 679926:MPET_RS04715
uniprot id: E1RJP4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06815
gene id: 679926:MPET_RS06815
uniprot id: E1RET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

679926:MPET RS07815
gene id: 679926:MPET_RS07815
uniprot id: E1RG62
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679926:MPET RS10635
gene id: 679926:MPET_RS10635
uniprot id: E1RJX3
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

679926:MPET RS07745
gene id: 679926:MPET_RS07745
uniprot id: E1RG49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

679926:MPET RS01460
gene id: 679926:MPET_RS01460
uniprot id: E1RFB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

679926:MPET RS10550
gene id: 679926:MPET_RS10550
uniprot id: E1RJV6
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

679926:MPET RS01660
gene id: 679926:MPET_RS01660
uniprot id: E1RFV2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS00530
gene id: 679926:MPET_RS00530
uniprot id: E1RDZ5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

679926:MPET RS02995
gene id: 679926:MPET_RS02995
uniprot id: E1RHQ5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

679926:MPET RS01730
gene id: 679926:MPET_RS01730
uniprot id: E1RFW5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

679926:MPET RS08710
gene id: 679926:MPET_RS08710
uniprot id: E1RHT9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03165
gene id: 679926:MPET_RS03165
uniprot id: E1RI14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS13170
gene id: 679926:MPET_RS13170
uniprot id: E1RFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

679926:MPET RS11515
gene id: 679926:MPET_RS11515
uniprot id: E1RD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679926:MPET RS03645
gene id: 679926:MPET_RS03645
uniprot id: E1RII3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

679926:MPET RS09780
gene id: 679926:MPET_RS09780
uniprot id: E1RJ17
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

679926:MPET RS07065
gene id: 679926:MPET_RS07065
uniprot id: E1REY1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

679926:MPET RS09470
gene id: 679926:MPET_RS09470
uniprot id: E1RIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

679926:MPET RS08780
gene id: 679926:MPET_RS08780
uniprot id: E1RHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS01965
gene id: 679926:MPET_RS01965
uniprot id: E1RGF2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

679926:MPET RS13850
gene id: 679926:MPET_RS13850
uniprot id: E1RGV8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13155
gene id: 679926:MPET_RS13155
uniprot id: E1RFP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

679926:MPET RS06450
gene id: 679926:MPET_RS06450
uniprot id: E1RE68
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

679926:MPET RS08825
gene id: 679926:MPET_RS08825
uniprot id: E1RHV9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03250
gene id: 679926:MPET_RS03250
uniprot id: E1RI31
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09350
gene id: 679926:MPET_RS09350
uniprot id: E1RIK9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

679926:MPET RS11155
gene id: 679926:MPET_RS11155
uniprot id: E1RKM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

679926:MPET RS14270
gene id: 679926:MPET_RS14270
uniprot id: E1RDD9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08865
gene id: 679926:MPET_RS08865
uniprot id: E1RHW6
names: Function
messages: Part of a potassium transport system.

679926:MPET RS04220
gene id: 679926:MPET_RS04220
uniprot id: E1RJ81
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

679926:MPET RS07940
gene id: 679926:MPET_RS07940
uniprot id: E1RGM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

679926:MPET RS02160
gene id: 679926:MPET_RS02160
uniprot id: E1RGI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

679926:MPET RS04745
gene id: 679926:MPET_RS04745
uniprot id: E1RJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

679926:MPET RS10030
gene id: 679926:MPET_RS10030
uniprot id: E1RJ65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS12175
gene id: 679926:MPET_RS12175
uniprot id: E1RDX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS10865
gene id: 679926:MPET_RS10865
uniprot id: E1RK89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

679926:MPET RS13400
gene id: 679926:MPET_RS13400
uniprot id: E1RG86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

679926:MPET RS10245
gene id: 679926:MPET_RS10245
uniprot id: E1RJH2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

679926:MPET RS06720
gene id: 679926:MPET_RS06720
uniprot id: E1REC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS10990
gene id: 679926:MPET_RS10990
uniprot id: E1RKB3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

679926:MPET RS04280
gene id: 679926:MPET_RS04280
uniprot id: E1RJ92
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

679926:MPET RS13340
gene id: 679926:MPET_RS13340
uniprot id: E1RG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

679926:MPET RS12265
gene id: 679926:MPET_RS12265
uniprot id: E1RED3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03995
gene id: 679926:MPET_RS03995
uniprot id: E1RIX0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

679926:MPET RS13705
gene id: 679926:MPET_RS13705
uniprot id: E1RGS9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS07290
gene id: 679926:MPET_RS07290
uniprot id: E1RFG6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04865
gene id: 679926:MPET_RS04865
uniprot id: E1RJS3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13095
gene id: 679926:MPET_RS13095
uniprot id: E1RFN4
names: Similarity
messages: Belongs to the archaeal-type GPI family.

679926:MPET RS03515
gene id: 679926:MPET_RS03515
uniprot id: E1RIF7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09385
gene id: 679926:MPET_RS09385
uniprot id: E1RIL6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

679926:MPET RS06805
gene id: 679926:MPET_RS06805
uniprot id: E1RET1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

679926:MPET RS13115
gene id: 679926:MPET_RS13115
uniprot id: E1RFN8
names: Subcellular Location Annotation
messages: Cytoplasm

679926:MPET RS12240
gene id: 679926:MPET_RS12240
uniprot id: E1REC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS03080
gene id: 679926:MPET_RS03080
uniprot id: E1RHZ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06405
gene id: 679926:MPET_RS06405
uniprot id: E1RE59
names: Similarity
messages: Belongs to the glutamate synthase family.

679926:MPET RS08775
gene id: 679926:MPET_RS08775
uniprot id: E1RHV2
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

679926:MPET RS10545
gene id: 679926:MPET_RS10545
uniprot id: E1RJV5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

679926:MPET RS04900
gene id: 679926:MPET_RS04900
uniprot id: E1RK04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS11085
gene id: 679926:MPET_RS11085
uniprot id: E1RKD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS00565
gene id: 679926:MPET_RS00565
uniprot id: E1RE01
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04245
gene id: 679926:MPET_RS04245
uniprot id: E1RJ86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

679926:MPET RS10105
gene id: 679926:MPET_RS10105
uniprot id: E1RJE4
names: Similarity
messages: Belongs to the UPF0254 family.

679926:MPET RS10600
gene id: 679926:MPET_RS10600
uniprot id: E1RJW6
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10795
gene id: 679926:MPET_RS10795
uniprot id: E1RK76
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

679926:MPET RS10810
gene id: 679926:MPET_RS10810
uniprot id: E1RK79
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

679926:MPET RS00830
gene id: 679926:MPET_RS00830
uniprot id: E1RE49
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

679926:MPET RS01075
gene id: 679926:MPET_RS01075
uniprot id: E1REP1
names: Similarity
messages: Belongs to the peptidase U62 family.

679926:MPET RS09320
gene id: 679926:MPET_RS09320
uniprot id: E1RIK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679926:MPET RS12505
gene id: 679926:MPET_RS12505
uniprot id: E1REH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679926:MPET RS04990
gene id: 679926:MPET_RS04990
uniprot id: E1RK18
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

679926:MPET RS09590
gene id: 679926:MPET_RS09590
uniprot id: E1RIQ7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

679926:MPET RS12515
gene id: 679926:MPET_RS12515
uniprot id: E1REH4
names: Similarity
messages: Belongs to the HdrC family.

679926:MPET RS10450
gene id: 679926:MPET_RS10450
uniprot id: E1RJT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS11070
gene id: 679926:MPET_RS11070
uniprot id: E1RKC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS09825
gene id: 679926:MPET_RS09825
uniprot id: E1RJ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

679926:MPET RS05255
gene id: 679926:MPET_RS05255
uniprot id: E1RK68
names: Similarity
messages: Belongs to the DNase I family.

679926:MPET RS13395
gene id: 679926:MPET_RS13395
uniprot id: E1RG85
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

679926:MPET RS02950
gene id: 679926:MPET_RS02950
uniprot id: E1RHP6
names: Similarity
messages: Belongs to the AAA ATPase family.

679926:MPET RS03860
gene id: 679926:MPET_RS03860
uniprot id: E1RIU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS12200
gene id: 679926:MPET_RS12200
uniprot id: E1RDX6
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

679926:MPET RS02275
gene id: 679926:MPET_RS02275
uniprot id: E1RGZ8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10950
gene id: 679926:MPET_RS10950
uniprot id: E1RKA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

679926:MPET RS10480
gene id: 679926:MPET_RS10480
uniprot id: E1RJU1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679926:MPET RS03745
gene id: 679926:MPET_RS03745
uniprot id: E1RIJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS04880
gene id: 679926:MPET_RS04880
uniprot id: E1RK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679926:MPET RS11115
gene id: 679926:MPET_RS11115
uniprot id: E1RKD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS08720
gene id: 679926:MPET_RS08720
uniprot id: E1RHU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

679926:MPET RS12365
gene id: 679926:MPET_RS12365
uniprot id: E1REF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS04605
gene id: 679926:MPET_RS04605
uniprot id: E1RJM4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06630
gene id: 679926:MPET_RS06630
uniprot id: E1REA3
names: Similarity
messages: Belongs to the UPF0235 family.

679926:MPET RS06615
gene id: 679926:MPET_RS06615
uniprot id: E1REA0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

679926:MPET RS00210
gene id: 679926:MPET_RS00210
uniprot id: E1RDD8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01525
gene id: 679926:MPET_RS01525
uniprot id: E1RFD1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

679926:MPET RS07635
gene id: 679926:MPET_RS07635
uniprot id: E1RG28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS13065
gene id: 679926:MPET_RS13065
uniprot id: E1RFM8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

679926:MPET RS10070
gene id: 679926:MPET_RS10070
uniprot id: E1RJD7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679926:MPET RS12950
gene id: 679926:MPET_RS12950
uniprot id: E1RFK7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

679926:MPET RS00820
gene id: 679926:MPET_RS00820
uniprot id: E1RE47
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

679926:MPET RS03650
gene id: 679926:MPET_RS03650
uniprot id: E1RII4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS10560
gene id: 679926:MPET_RS10560
uniprot id: E1RJV8
names: Subcellular Location Annotation
messages: Cytoplasm

679926:MPET RS00730
gene id: 679926:MPET_RS00730
uniprot id: E1RE30
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS01065
gene id: 679926:MPET_RS01065
uniprot id: E1REN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

679926:MPET RS08885
gene id: 679926:MPET_RS08885
uniprot id: E1RHX0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

679926:MPET RS00145
gene id: 679926:MPET_RS00145
uniprot id: E1RDC6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

679926:MPET RS04870
gene id: 679926:MPET_RS04870
uniprot id: E1RJS4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

679926:MPET RS10435
gene id: 679926:MPET_RS10435
uniprot id: E1RJT2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

679926:MPET RS12170
gene id: 679926:MPET_RS12170
uniprot id: E1RDX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS01980
gene id: 679926:MPET_RS01980
uniprot id: E1RGF5
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09415
gene id: 679926:MPET_RS09415
uniprot id: E1RIM2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

679926:MPET RS05430
gene id: 679926:MPET_RS05430
uniprot id: E1RKH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06670
gene id: 679926:MPET_RS06670
uniprot id: E1REB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

679926:MPET RS11075
gene id: 679926:MPET_RS11075
uniprot id: E1RKD0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

679926:MPET RS00005
gene id: 679926:MPET_RS00005
uniprot id: E1RCV1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

679926:MPET RS10080
gene id: 679926:MPET_RS10080
uniprot id: E1RJD9
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679926:MPET RS09360
gene id: 679926:MPET_RS09360
uniprot id: E1RIL1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

679926:MPET RS08465
gene id: 679926:MPET_RS08465
uniprot id: E1RHC0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

679926:MPET RS13335
gene id: 679926:MPET_RS13335
uniprot id: E1RG73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

679926:MPET RS09375
gene id: 679926:MPET_RS09375
uniprot id: E1RIL4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

679926:MPET RS07665
gene id: 679926:MPET_RS07665
uniprot id: E1RG33
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

679926:MPET RS07755
gene id: 679926:MPET_RS07755
uniprot id: E1RG51
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

679926:MPET RS03840
gene id: 679926:MPET_RS03840
uniprot id: E1RIU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS02140
gene id: 679926:MPET_RS02140
uniprot id: E1RGI5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS13510
gene id: 679926:MPET_RS13510
uniprot id: E1RGA7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

679926:MPET RS10965
gene id: 679926:MPET_RS10965
uniprot id: E1RKA8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS05605
gene id: 679926:MPET_RS05605
uniprot id: E1RKK8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

679926:MPET RS09630
gene id: 679926:MPET_RS09630
uniprot id: E1RIR5
names: Similarity
messages: Belongs to the UPF0288 family.

679926:MPET RS09450
gene id: 679926:MPET_RS09450
uniprot id: E1RIM9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS10735
gene id: 679926:MPET_RS10735
uniprot id: E1RJZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

679926:MPET RS11975
gene id: 679926:MPET_RS11975
uniprot id: E1RDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679926:MPET RS08005
gene id: 679926:MPET_RS08005
uniprot id: E1RGP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS12020
gene id: 679926:MPET_RS12020
uniprot id: E1RDU3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

679926:MPET RS06770
gene id: 679926:MPET_RS06770
uniprot id: E1RES4
names: Similarity
messages: Belongs to the malic enzymes family.

679926:MPET RS12900
gene id: 679926:MPET_RS12900
uniprot id: E1RF57
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679926:MPET RS12755
gene id: 679926:MPET_RS12755
uniprot id: E1RF28
names: Similarity
messages: Belongs to the UPF0237 family.

679926:MPET RS08570
gene id: 679926:MPET_RS08570
uniprot id: E1RHE2
names: Subunit
messages: Homotetramer.

679926:MPET RS08110
gene id: 679926:MPET_RS08110
uniprot id: E1RGR2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

679926:MPET RS14245
gene id: 679926:MPET_RS14245
uniprot id: E1RHI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

679926:MPET RS02785
gene id: 679926:MPET_RS02785
uniprot id: E1RHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

679926:MPET RS07125
gene id: 679926:MPET_RS07125
uniprot id: E1REZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS13635
gene id: 679926:MPET_RS13635
uniprot id: E1RGD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

679926:MPET RS01465
gene id: 679926:MPET_RS01465
uniprot id: E1RFC0
names: Similarity
messages: Belongs to the DtxR/MntR family.

679926:MPET RS07140
gene id: 679926:MPET_RS07140
uniprot id: E1RFD6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06530
gene id: 679926:MPET_RS06530
uniprot id: E1RE84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

679926:MPET RS06455
gene id: 679926:MPET_RS06455
uniprot id: E1RE69
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679926:MPET RS08985
gene id: 679926:MPET_RS08985
uniprot id: E1RI63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

679926:MPET RS05150
gene id: 679926:MPET_RS05150
uniprot id: E1RK48
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

679926:MPET RS13935
gene id: 679926:MPET_RS13935
uniprot id: E1RGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

679926:MPET RS07750
gene id: 679926:MPET_RS07750
uniprot id: E1RG50
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

679926:MPET RS03865
gene id: 679926:MPET_RS03865
uniprot id: E1RIU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

679926:MPET RS13840
gene id: 679926:MPET_RS13840
uniprot id: E1RGV6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

679926:MPET RS04430
gene id: 679926:MPET_RS04430
uniprot id: E1RJC0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

679926:MPET RS01010
gene id: 679926:MPET_RS01010
uniprot id: E1REM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679926:MPET RS00900
gene id: 679926:MPET_RS00900
uniprot id: E1REK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS12960
gene id: 679926:MPET_RS12960
uniprot id: E1RFK9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

679926:MPET RS03660
gene id: 679926:MPET_RS03660
uniprot id: E1RII6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

679926:MPET RS06790
gene id: 679926:MPET_RS06790
uniprot id: E1RES8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

679926:MPET RS08760
gene id: 679926:MPET_RS08760
uniprot id: E1RHU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

679926:MPET RS12030
gene id: 679926:MPET_RS12030
uniprot id: E1RDU5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

679926:MPET RS13815
gene id: 679926:MPET_RS13815
uniprot id: E1RGV1
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08925
gene id: 679926:MPET_RS08925
uniprot id: E1RHX8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02545
gene id: 679926:MPET_RS02545
uniprot id: E1RH52
names: Similarity
messages: Belongs to the UPF0305 family.

679926:MPET RS10630
gene id: 679926:MPET_RS10630
uniprot id: E1RJX2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS11110
gene id: 679926:MPET_RS11110
uniprot id: E1RKD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS09530
gene id: 679926:MPET_RS09530
uniprot id: E1RIP5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS13185
gene id: 679926:MPET_RS13185
uniprot id: E1RFQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS10570
gene id: 679926:MPET_RS10570
uniprot id: E1RJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS10855
gene id: 679926:MPET_RS10855
uniprot id: E1RK87
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS13380
gene id: 679926:MPET_RS13380
uniprot id: E1RG82
names: Similarity
messages: Belongs to the ZPR1 family.

679926:MPET RS10715
gene id: 679926:MPET_RS10715
uniprot id: E1RJY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

679926:MPET RS02710
gene id: 679926:MPET_RS02710
uniprot id: E1RHK0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

679926:MPET RS07540
gene id: 679926:MPET_RS07540
uniprot id: E1RG10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

679926:MPET RS13575
gene id: 679926:MPET_RS13575
uniprot id: E1RGB8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

679926:MPET RS13310
gene id: 679926:MPET_RS13310
uniprot id: E1RFS7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03225
gene id: 679926:MPET_RS03225
uniprot id: E1RI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679926:MPET RS01130
gene id: 679926:MPET_RS01130
uniprot id: E1REQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679926:MPET RS09775
gene id: 679926:MPET_RS09775
uniprot id: E1RJ16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

679926:MPET RS13680
gene id: 679926:MPET_RS13680
uniprot id: E1RGD9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

679926:MPET RS09330
gene id: 679926:MPET_RS09330
uniprot id: E1RIK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS12320
gene id: 679926:MPET_RS12320
uniprot id: E1REE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS11780
gene id: 679926:MPET_RS11780
uniprot id: E1RDA5
names: Similarity
messages: Belongs to the UPF0251 family.

679926:MPET RS00585
gene id: 679926:MPET_RS00585
uniprot id: E1RE05
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06175
gene id: 679926:MPET_RS06175
uniprot id: E1RDM4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS02965
gene id: 679926:MPET_RS02965
uniprot id: E1RHP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

679926:MPET RS09435
gene id: 679926:MPET_RS09435
uniprot id: E1RIM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

679926:MPET RS01375
gene id: 679926:MPET_RS01375
uniprot id: E1RFA1
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

679926:MPET RS01165
gene id: 679926:MPET_RS01165
uniprot id: E1RER0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679926:MPET RS04010
gene id: 679926:MPET_RS04010
uniprot id: E1RIX3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

679926:MPET RS04695
gene id: 679926:MPET_RS04695
uniprot id: E1RJP1
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

679926:MPET RS03610
gene id: 679926:MPET_RS03610
uniprot id: E1RIH6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

679926:MPET RS06835
gene id: 679926:MPET_RS06835
uniprot id: E1RET6
names: Similarity
messages: Belongs to the HypD family.

679926:MPET RS12025
gene id: 679926:MPET_RS12025
uniprot id: E1RDU4
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS10625
gene id: 679926:MPET_RS10625
uniprot id: E1RJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

679926:MPET RS00380
gene id: 679926:MPET_RS00380
uniprot id: E1RDH2
names: Similarity
messages: Belongs to the UPF0285 family.

679926:MPET RS04025
gene id: 679926:MPET_RS04025
uniprot id: E1RIX6
names: Similarity
messages: Belongs to the UPF0147 family.

679926:MPET RS10650
gene id: 679926:MPET_RS10650
uniprot id: E1RJX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

679926:MPET RS09110
gene id: 679926:MPET_RS09110
uniprot id: E1RI89
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

679926:MPET RS04040
gene id: 679926:MPET_RS04040
uniprot id: E1RIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679926:MPET RS12560
gene id: 679926:MPET_RS12560
uniprot id: E1REI9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

679926:MPET RS06960
gene id: 679926:MPET_RS06960
uniprot id: E1REW0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

679926:MPET RS04675
gene id: 679926:MPET_RS04675
uniprot id: E1RJN7
names: Similarity
messages: Belongs to the TrpF family.

679926:MPET RS14485
gene id: 679926:MPET_RS14485
uniprot id: E1REW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

679926:MPET RS03205
gene id: 679926:MPET_RS03205
uniprot id: E1RI22
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

679926:MPET RS02095
gene id: 679926:MPET_RS02095
uniprot id: E1RGH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

679926:MPET RS08860
gene id: 679926:MPET_RS08860
uniprot id: E1RHW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

679926:MPET RS03115
gene id: 679926:MPET_RS03115
uniprot id: E1RI03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

679926:MPET RS09760
gene id: 679926:MPET_RS09760
uniprot id: E1RJ13
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

679926:MPET RS02865
gene id: 679926:MPET_RS02865
uniprot id: E1RHN0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS13430
gene id: 679926:MPET_RS13430
uniprot id: E1RG91
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

679926:MPET RS11095
gene id: 679926:MPET_RS11095
uniprot id: E1RKD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

679926:MPET RS02285
gene id: 679926:MPET_RS02285
uniprot id: E1RH00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS13655
gene id: 679926:MPET_RS13655
uniprot id: E1RGD4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS02505
gene id: 679926:MPET_RS02505
uniprot id: E1RH44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

679926:MPET RS02185
gene id: 679926:MPET_RS02185
uniprot id: E1RGJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS03620
gene id: 679926:MPET_RS03620
uniprot id: E1RIH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679926:MPET RS02360
gene id: 679926:MPET_RS02360
uniprot id: E1RH15
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

679926:MPET RS05050
gene id: 679926:MPET_RS05050
uniprot id: E1RK30
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

679926:MPET RS07130
gene id: 679926:MPET_RS07130
uniprot id: E1REZ3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS03725
gene id: 679926:MPET_RS03725
uniprot id: E1RIJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

679926:MPET RS12910
gene id: 679926:MPET_RS12910
uniprot id: E1RF59
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

679926:MPET RS02520
gene id: 679926:MPET_RS02520
uniprot id: E1RH47
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS13865
gene id: 679926:MPET_RS13865
uniprot id: E1RGW1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS09335
gene id: 679926:MPET_RS09335
uniprot id: E1RIK6
names: Similarity
messages: Belongs to the PDCD5 family.

679926:MPET RS08365
gene id: 679926:MPET_RS08365
uniprot id: E1RHA0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

679926:MPET RS06955
gene id: 679926:MPET_RS06955
uniprot id: E1REV9
names: Similarity
messages: Belongs to the TPP enzyme family.

679926:MPET RS06900
gene id: 679926:MPET_RS06900
uniprot id: E1REU8
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08195
gene id: 679926:MPET_RS08195
uniprot id: E1RH70
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS05465
gene id: 679926:MPET_RS05465
uniprot id: E1RKI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

679926:MPET RS02570
gene id: 679926:MPET_RS02570
uniprot id: E1RH56
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

679926:MPET RS10025
gene id: 679926:MPET_RS10025
uniprot id: E1RJ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

679926:MPET RS06425
gene id: 679926:MPET_RS06425
uniprot id: E1RE63
names: Similarity
messages: Belongs to the P(II) protein family.

679926:MPET RS07780
gene id: 679926:MPET_RS07780
uniprot id: E1RG55
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

679926:MPET RS02005
gene id: 679926:MPET_RS02005
uniprot id: E1RGF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679926:MPET RS03815
gene id: 679926:MPET_RS03815
uniprot id: E1RIT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

679926:MPET RS13690
gene id: 679926:MPET_RS13690
uniprot id: E1RGE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

679926:MPET RS12040
gene id: 679926:MPET_RS12040
uniprot id: E1RDU7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

679926:MPET RS09270
gene id: 679926:MPET_RS09270
uniprot id: E1RIB9
names: Caution
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06325
gene id: 679926:MPET_RS06325
uniprot id: E1RDQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

679926:MPET RS07700
gene id: 679926:MPET_RS07700
uniprot id: E1RG40
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

679926:MPET RS03460
gene id: 679926:MPET_RS03460
uniprot id: E1RIE5
names: Similarity
messages: Belongs to the UPF0284 family.

679926:MPET RS13830
gene id: 679926:MPET_RS13830
uniprot id: E1RGV4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09155
gene id: 679926:MPET_RS09155
uniprot id: E1RI97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

679926:MPET RS03470
gene id: 679926:MPET_RS03470
uniprot id: E1RIE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

679926:MPET RS05560
gene id: 679926:MPET_RS05560
uniprot id: E1RKJ9
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08025
gene id: 679926:MPET_RS08025
uniprot id: E1RGP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS01015
gene id: 679926:MPET_RS01015
uniprot id: E1REM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

679926:MPET RS09740
gene id: 679926:MPET_RS09740
uniprot id: E1RJ09
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

679926:MPET RS11915
gene id: 679926:MPET_RS11915
uniprot id: E1RDS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

679926:MPET RS01745
gene id: 679926:MPET_RS01745
uniprot id: E1RFW8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS00385
gene id: 679926:MPET_RS00385
uniprot id: E1RDH3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS00115
gene id: 679926:MPET_RS00115
uniprot id: E1RDC0
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00035
gene id: 679926:MPET_RS00035
uniprot id: E1RCV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

679926:MPET RS13675
gene id: 679926:MPET_RS13675
uniprot id: E1RGD8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS10520
gene id: 679926:MPET_RS10520
uniprot id: E1RJV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

679926:MPET RS04565
gene id: 679926:MPET_RS04565
uniprot id: E1RJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679926:MPET RS01155
gene id: 679926:MPET_RS01155
uniprot id: E1REQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

679926:MPET RS02775
gene id: 679926:MPET_RS02775
uniprot id: E1RHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

679926:MPET RS03550
gene id: 679926:MPET_RS03550
uniprot id: E1RIG4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679926:MPET RS03875
gene id: 679926:MPET_RS03875
uniprot id: E1RIU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

679926:MPET RS12785
gene id: 679926:MPET_RS12785
uniprot id: E1RF35
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS11415
gene id: 679926:MPET_RS11415
uniprot id: E1RKS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

679926:MPET RS06470
gene id: 679926:MPET_RS06470
uniprot id: E1RE72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

679926:MPET RS04285
gene id: 679926:MPET_RS04285
uniprot id: E1RJ93
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS12100
gene id: 679926:MPET_RS12100
uniprot id: E1RDW0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

679926:MPET RS02685
gene id: 679926:MPET_RS02685
uniprot id: E1RHJ5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

679926:MPET RS10150
gene id: 679926:MPET_RS10150
uniprot id: E1RJF2
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

679926:MPET RS07695
gene id: 679926:MPET_RS07695
uniprot id: E1RG39
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS04760
gene id: 679926:MPET_RS04760
uniprot id: E1RJQ3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS08330
gene id: 679926:MPET_RS08330
uniprot id: E1RH93
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01300
gene id: 679926:MPET_RS01300
uniprot id: E1RF87
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

679926:MPET RS08745
gene id: 679926:MPET_RS08745
uniprot id: E1RHU6
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

679926:MPET RS14060
gene id: 679926:MPET_RS14060
uniprot id: E1RHE6
names: Similarity
messages: Belongs to the hemerythrin family.

679926:MPET RS01600
gene id: 679926:MPET_RS01600
uniprot id: E1RFU0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679926:MPET RS05520
gene id: 679926:MPET_RS05520
uniprot id: E1RKJ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS09700
gene id: 679926:MPET_RS09700
uniprot id: E1RJ01
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00775
gene id: 679926:MPET_RS00775
uniprot id: E1RE39
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

679926:MPET RS00075
gene id: 679926:MPET_RS00075
uniprot id: E1RCW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS09765
gene id: 679926:MPET_RS09765
uniprot id: E1RJ14
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

679926:MPET RS05190
gene id: 679926:MPET_RS05190
uniprot id: E1RK55
names: Similarity
messages: Belongs to the serpin family.

679926:MPET RS00945
gene id: 679926:MPET_RS00945
uniprot id: E1REL6
names: Similarity
messages: Belongs to the carbamate kinase family.

679926:MPET RS04905
gene id: 679926:MPET_RS04905
uniprot id: E1RK05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679926:MPET RS09845
gene id: 679926:MPET_RS09845
uniprot id: E1RJ30
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS05810
gene id: 679926:MPET_RS05810
uniprot id: E1RD05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679926:MPET RS10760
gene id: 679926:MPET_RS10760
uniprot id: E1RJZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

679926:MPET RS03855
gene id: 679926:MPET_RS03855
uniprot id: E1RIU4
names: Similarity
messages: Belongs to the MEMO1 family.

679926:MPET RS02065
gene id: 679926:MPET_RS02065
uniprot id: E1RGH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS10765
gene id: 679926:MPET_RS10765
uniprot id: E1RJZ9
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

679926:MPET RS00020
gene id: 679926:MPET_RS00020
uniprot id: E1RCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

679926:MPET RS10610
gene id: 679926:MPET_RS10610
uniprot id: E1RJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

679926:MPET RS01720
gene id: 679926:MPET_RS01720
uniprot id: E1RFW3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

679926:MPET RS06740
gene id: 679926:MPET_RS06740
uniprot id: E1RER8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

679926:MPET RS03885
gene id: 679926:MPET_RS03885
uniprot id: E1RIV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

679926:MPET RS10175
gene id: 679926:MPET_RS10175
uniprot id: E1RJF7
names: Similarity
messages: Belongs to the UPF0212 family.

679926:MPET RS11410
gene id: 679926:MPET_RS11410
uniprot id: E1RKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

679926:MPET RS05205
gene id: 679926:MPET_RS05205
uniprot id: E1RK58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

679926:MPET RS09345
gene id: 679926:MPET_RS09345
uniprot id: E1RIK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

679926:MPET RS03615
gene id: 679926:MPET_RS03615
uniprot id: E1RIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679926:MPET RS05505
gene id: 679926:MPET_RS05505
uniprot id: E1RKI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

679926:MPET RS04210
gene id: 679926:MPET_RS04210
uniprot id: E1RJ79
names: Similarity
messages: Belongs to the NadC/ModD family.

679926:MPET RS10720
gene id: 679926:MPET_RS10720
uniprot id: E1RJZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

679926:MPET RS12185
gene id: 679926:MPET_RS12185
uniprot id: E1RDX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679926:MPET RS07475
gene id: 679926:MPET_RS07475
uniprot id: E1RFK3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS09830
gene id: 679926:MPET_RS09830
uniprot id: E1RJ27
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS11335
gene id: 679926:MPET_RS11335
uniprot id: E1RKQ6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679926:MPET RS13765
gene id: 679926:MPET_RS13765
uniprot id: E1RGU1
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00470
gene id: 679926:MPET_RS00470
uniprot id: E1RDY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

679926:MPET RS12010
gene id: 679926:MPET_RS12010
uniprot id: E1RDU1
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

679926:MPET RS11555
gene id: 679926:MPET_RS11555
uniprot id: E1RD56
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

679926:MPET RS03965
gene id: 679926:MPET_RS03965
uniprot id: E1RIW4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

679926:MPET RS04260
gene id: 679926:MPET_RS04260
uniprot id: E1RJ88
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679926:MPET RS04055
gene id: 679926:MPET_RS04055
uniprot id: E1RIY2
names: Similarity
messages: Belongs to the UPF0173 family.

679926:MPET RS06260
gene id: 679926:MPET_RS06260
uniprot id: E1RDP1
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS11505
gene id: 679926:MPET_RS11505
uniprot id: E1RD46
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

679926:MPET RS04340
gene id: 679926:MPET_RS04340
uniprot id: E1RJA4
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS01135
gene id: 679926:MPET_RS01135
uniprot id: E1REQ3
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS04825
gene id: 679926:MPET_RS04825
uniprot id: E1RJR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

679926:MPET RS12790
gene id: 679926:MPET_RS12790
uniprot id: E1RF36
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS05575
gene id: 679926:MPET_RS05575
uniprot id: E1RKK2
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS06510
gene id: 679926:MPET_RS06510
uniprot id: E1RE80
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

679926:MPET RS12045
gene id: 679926:MPET_RS12045
uniprot id: E1RDU8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS11805
gene id: 679926:MPET_RS11805
uniprot id: E1RDB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

679926:MPET RS04555
gene id: 679926:MPET_RS04555
uniprot id: E1RJL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679926:MPET RS12800
gene id: 679926:MPET_RS12800
uniprot id: E1RF38
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS11160
gene id: 679926:MPET_RS11160
uniprot id: E1RKM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

679926:MPET RS13225
gene id: 679926:MPET_RS13225
uniprot id: E1RFR0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

679926:MPET RS06695
gene id: 679926:MPET_RS06695
uniprot id: E1REB7
names: Subcellular Location Annotation
messages: Membrane

679926:MPET RS00590
gene id: 679926:MPET_RS00590
uniprot id: E1RE06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

679926:MPET RS12970
gene id: 679926:MPET_RS12970
uniprot id: E1RFL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

679926:MPET RS02575
gene id: 679926:MPET_RS02575
uniprot id: E1RH57
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

679926:MPET RS03380
gene id: 679926:MPET_RS03380
uniprot id: E1RIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679926:MPET RS12780
gene id: 679926:MPET_RS12780
uniprot id: E1RF34
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

679926:MPET RS10685
gene id: 679926:MPET_RS10685
uniprot id: E1RJY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

679926:MPET RS07740
gene id: 679926:MPET_RS07740
uniprot id: E1RG48
names: Similarity
messages: Belongs to the HMBS family.

679926:MPET RS03910
gene id: 679926:MPET_RS03910
uniprot id: E1RIV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

679926:MPET RS05970
gene id: 679926:MPET_RS05970
uniprot id: E1RD35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679926:MPET RS06270
gene id: 679926:MPET_RS06270
uniprot id: E1RDP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.