667014:THEIN RS04465
gene id: 667014:THEIN_RS04465
uniprot id: F8ACW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

667014:THEIN RS07525
gene id: 667014:THEIN_RS07525
uniprot id: F8AA52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

667014:THEIN RS00670
gene id: 667014:THEIN_RS00670
uniprot id: F8A8X1
names: Similarity
messages: Belongs to the UPF0434 family.

667014:THEIN RS01175
gene id: 667014:THEIN_RS01175
uniprot id: F8A9H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

667014:THEIN RS03975
gene id: 667014:THEIN_RS03975
uniprot id: F8ACG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

667014:THEIN RS05725
gene id: 667014:THEIN_RS05725
uniprot id: F8A804
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

667014:THEIN RS11185
gene id: 667014:THEIN_RS11185
uniprot id: F8ADT0
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

667014:THEIN RS01665
gene id: 667014:THEIN_RS01665
uniprot id: F8AA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS10840
gene id: 667014:THEIN_RS10840
uniprot id: F8ADF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS10665
gene id: 667014:THEIN_RS10665
uniprot id: F8ADC2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07835
gene id: 667014:THEIN_RS07835
uniprot id: F8AAH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

667014:THEIN RS01885
gene id: 667014:THEIN_RS01885
uniprot id: F8AAB8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

667014:THEIN RS11215
gene id: 667014:THEIN_RS11215
uniprot id: F8ADT6
names: Similarity
messages: Belongs to the P(II) protein family.

667014:THEIN RS05380
gene id: 667014:THEIN_RS05380
uniprot id: F8ADW4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

667014:THEIN RS00425
gene id: 667014:THEIN_RS00425
uniprot id: F8AE38
names: Similarity
messages: Belongs to the RemA family.

667014:THEIN RS09045
gene id: 667014:THEIN_RS09045
uniprot id: F8ABN1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS09540
gene id: 667014:THEIN_RS09540
uniprot id: F8AC92
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

667014:THEIN RS00525
gene id: 667014:THEIN_RS00525
uniprot id: F8A8U3
names: Subunit
messages: Homodimer.

667014:THEIN RS03170
gene id: 667014:THEIN_RS03170
uniprot id: F8ABQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS11205
gene id: 667014:THEIN_RS11205
uniprot id: F8ADT4
names: Similarity
messages: Belongs to the glutamine synthetase family.

667014:THEIN RS00940
gene id: 667014:THEIN_RS00940
uniprot id: F8A9D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

667014:THEIN RS08620
gene id: 667014:THEIN_RS08620
uniprot id: F8AB92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

667014:THEIN RS05710
gene id: 667014:THEIN_RS05710
uniprot id: F8A801
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

667014:THEIN RS08640
gene id: 667014:THEIN_RS08640
uniprot id: F8AB95
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

667014:THEIN RS08150
gene id: 667014:THEIN_RS08150
uniprot id: F8AAU7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

667014:THEIN RS03150
gene id: 667014:THEIN_RS03150
uniprot id: F8ABQ5
names: Similarity
messages: Belongs to the peptidase M16 family.

667014:THEIN RS02405
gene id: 667014:THEIN_RS02405
uniprot id: F8AAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

667014:THEIN RS09575
gene id: 667014:THEIN_RS09575
uniprot id: F8AC98
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

667014:THEIN RS00900
gene id: 667014:THEIN_RS00900
uniprot id: F8A9C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

667014:THEIN RS10335
gene id: 667014:THEIN_RS10335
uniprot id: F8AD08
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS08325
gene id: 667014:THEIN_RS08325
uniprot id: F8AAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

667014:THEIN RS06505
gene id: 667014:THEIN_RS06505
uniprot id: F8A918
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

667014:THEIN RS06330
gene id: 667014:THEIN_RS06330
uniprot id: F8A8M2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

667014:THEIN RS10940
gene id: 667014:THEIN_RS10940
uniprot id: F8ADH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

667014:THEIN RS06275
gene id: 667014:THEIN_RS06275
uniprot id: F8A8L4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

667014:THEIN RS05785
gene id: 667014:THEIN_RS05785
uniprot id: F8A814
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

667014:THEIN RS06860
gene id: 667014:THEIN_RS06860
uniprot id: F8A9J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

667014:THEIN RS05765
gene id: 667014:THEIN_RS05765
uniprot id: F8A810
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

667014:THEIN RS09680
gene id: 667014:THEIN_RS09680
uniprot id: F8A9R2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

667014:THEIN RS01015
gene id: 667014:THEIN_RS01015
uniprot id: F8A9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS10250
gene id: 667014:THEIN_RS10250
uniprot id: F8ACZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

667014:THEIN RS00380
gene id: 667014:THEIN_RS00380
uniprot id: F8AE36
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

667014:THEIN RS09300
gene id: 667014:THEIN_RS09300
uniprot id: F8A9Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

667014:THEIN RS10150
gene id: 667014:THEIN_RS10150
uniprot id: F8ACR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

667014:THEIN RS10320
gene id: 667014:THEIN_RS10320
uniprot id: F8AD05
names: Similarity
messages: Belongs to the histone deacetylase family.

667014:THEIN RS05790
gene id: 667014:THEIN_RS05790
uniprot id: F8A815
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

667014:THEIN RS10710
gene id: 667014:THEIN_RS10710
uniprot id: F8ADD1
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

667014:THEIN RS08585
gene id: 667014:THEIN_RS08585
uniprot id: F8AB86
names: Similarity
messages: Belongs to the UPF0047 family.

667014:THEIN RS04475
gene id: 667014:THEIN_RS04475
uniprot id: F8A8P8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

667014:THEIN RS08755
gene id: 667014:THEIN_RS08755
uniprot id: F8ABH8
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

667014:THEIN RS01835
gene id: 667014:THEIN_RS01835
uniprot id: F8AAA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS05565
gene id: 667014:THEIN_RS05565
uniprot id: F8A8S2
names: Similarity
messages: Belongs to the leucine-binding protein family.

667014:THEIN RS00055
gene id: 667014:THEIN_RS00055
uniprot id: F8A7Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

667014:THEIN RS05700
gene id: 667014:THEIN_RS05700
uniprot id: F8AE21
names: Similarity
messages: Belongs to the TrpC family.

667014:THEIN RS11690
gene id: 667014:THEIN_RS11690
uniprot id: F8AAK0
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS02265
gene id: 667014:THEIN_RS02265
uniprot id: F8AAQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

667014:THEIN RS05035
gene id: 667014:THEIN_RS05035
uniprot id: F8ADI7
names: Similarity
messages: Belongs to the CinA family.

667014:THEIN RS00575
gene id: 667014:THEIN_RS00575
uniprot id: F8A8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

667014:THEIN RS04025
gene id: 667014:THEIN_RS04025
uniprot id: F8ACH6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

667014:THEIN RS02445
gene id: 667014:THEIN_RS02445
uniprot id: F8AB04
names: Similarity
messages: Belongs to the NadC/ModD family.

667014:THEIN RS04135
gene id: 667014:THEIN_RS04135
uniprot id: F8ACJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

667014:THEIN RS09525
gene id: 667014:THEIN_RS09525
uniprot id: F8AC89
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

667014:THEIN RS02705
gene id: 667014:THEIN_RS02705
uniprot id: F8AB47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

667014:THEIN RS11055
gene id: 667014:THEIN_RS11055
uniprot id: F8ADQ8
names: Similarity
messages: Belongs to the RecJ family.

667014:THEIN RS05135
gene id: 667014:THEIN_RS05135
uniprot id: F8ADK6
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07430
gene id: 667014:THEIN_RS07430
uniprot id: F8AA33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

667014:THEIN RS07100
gene id: 667014:THEIN_RS07100
uniprot id: F8A9N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

667014:THEIN RS03740
gene id: 667014:THEIN_RS03740
uniprot id: F8AC65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

667014:THEIN RS02795
gene id: 667014:THEIN_RS02795
uniprot id: F8ABC7
names: Subcellular Location Annotation
messages: Cytoplasm

667014:THEIN RS05295
gene id: 667014:THEIN_RS05295
uniprot id: F8ADM8
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

667014:THEIN RS11380
gene id: 667014:THEIN_RS11380
uniprot id: F8AE31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

667014:THEIN RS03005
gene id: 667014:THEIN_RS03005
uniprot id: F8ABG4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

667014:THEIN RS07190
gene id: 667014:THEIN_RS07190
uniprot id: F8A9P6
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS10835
gene id: 667014:THEIN_RS10835
uniprot id: F8ADF6
names: Similarity
messages: Belongs to the GSP E family.

667014:THEIN RS02330
gene id: 667014:THEIN_RS02330
uniprot id: F8A871
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

667014:THEIN RS08330
gene id: 667014:THEIN_RS08330
uniprot id: F8AAX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS05455
gene id: 667014:THEIN_RS05455
uniprot id: F8ADX9
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

667014:THEIN RS02235
gene id: 667014:THEIN_RS02235
uniprot id: F8AAQ3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

667014:THEIN RS03820
gene id: 667014:THEIN_RS03820
uniprot id: F8AC75
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

667014:THEIN RS09180
gene id: 667014:THEIN_RS09180
uniprot id: F8ABW7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07300
gene id: 667014:THEIN_RS07300
uniprot id: F8AA12
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

667014:THEIN RS06335
gene id: 667014:THEIN_RS06335
uniprot id: F8A8M3
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS08365
gene id: 667014:THEIN_RS08365
uniprot id: F8AAY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

667014:THEIN RS08405
gene id: 667014:THEIN_RS08405
uniprot id: F8AB52
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

667014:THEIN RS10305
gene id: 667014:THEIN_RS10305
uniprot id: F8AD02
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

667014:THEIN RS02855
gene id: 667014:THEIN_RS02855
uniprot id: F8ABD9
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09210
gene id: 667014:THEIN_RS09210
uniprot id: F8ABX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

667014:THEIN RS07540
gene id: 667014:THEIN_RS07540
uniprot id: F8AA55
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

667014:THEIN RS06625
gene id: 667014:THEIN_RS06625
uniprot id: F8A941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS04075
gene id: 667014:THEIN_RS04075
uniprot id: F8ACI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS09495
gene id: 667014:THEIN_RS09495
uniprot id: F8AC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS00500
gene id: 667014:THEIN_RS00500
uniprot id: F8A8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

667014:THEIN RS07440
gene id: 667014:THEIN_RS07440
uniprot id: F8AA35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

667014:THEIN RS04895
gene id: 667014:THEIN_RS04895
uniprot id: F8AD99
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

667014:THEIN RS01605
gene id: 667014:THEIN_RS01605
uniprot id: F8A9Z3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

667014:THEIN RS01490
gene id: 667014:THEIN_RS01490
uniprot id: F8A9X5
names: Similarity
messages: Belongs to the peptidase A31 family.

667014:THEIN RS08310
gene id: 667014:THEIN_RS08310
uniprot id: F8AAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS08300
gene id: 667014:THEIN_RS08300
uniprot id: F8AAX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

667014:THEIN RS11060
gene id: 667014:THEIN_RS11060
uniprot id: F8ADQ9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

667014:THEIN RS07020
gene id: 667014:THEIN_RS07020
uniprot id: F8A9M0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

667014:THEIN RS02790
gene id: 667014:THEIN_RS02790
uniprot id: F8ABC6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS10690
gene id: 667014:THEIN_RS10690
uniprot id: F8ADC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

667014:THEIN RS01860
gene id: 667014:THEIN_RS01860
uniprot id: F8AAB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

667014:THEIN RS07550
gene id: 667014:THEIN_RS07550
uniprot id: F8AA57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

667014:THEIN RS09235
gene id: 667014:THEIN_RS09235
uniprot id: F8ABX8
names: Subcellular Location Annotation
messages: Cytoplasm

667014:THEIN RS10470
gene id: 667014:THEIN_RS10470
uniprot id: F8AD29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

667014:THEIN RS09020
gene id: 667014:THEIN_RS09020
uniprot id: F8ABM6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

667014:THEIN RS02560
gene id: 667014:THEIN_RS02560
uniprot id: F8A872
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

667014:THEIN RS02985
gene id: 667014:THEIN_RS02985
uniprot id: F8A880
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

667014:THEIN RS09205
gene id: 667014:THEIN_RS09205
uniprot id: F8ABX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

667014:THEIN RS05795
gene id: 667014:THEIN_RS05795
uniprot id: F8A816
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

667014:THEIN RS01155
gene id: 667014:THEIN_RS01155
uniprot id: F8AE48
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

667014:THEIN RS10265
gene id: 667014:THEIN_RS10265
uniprot id: F8ACZ5
names: Similarity
messages: Belongs to the HypD family.

667014:THEIN RS02185
gene id: 667014:THEIN_RS02185
uniprot id: F8AAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

667014:THEIN RS11375
gene id: 667014:THEIN_RS11375
uniprot id: F8AE30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

667014:THEIN RS02290
gene id: 667014:THEIN_RS02290
uniprot id: F8A867
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

667014:THEIN RS05505
gene id: 667014:THEIN_RS05505
uniprot id: F8ADY9
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07840
gene id: 667014:THEIN_RS07840
uniprot id: F8AAI0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

667014:THEIN RS09000
gene id: 667014:THEIN_RS09000
uniprot id: F8ABM2
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

667014:THEIN RS07055
gene id: 667014:THEIN_RS07055
uniprot id: F8A9M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

667014:THEIN RS10845
gene id: 667014:THEIN_RS10845
uniprot id: F8ADF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

667014:THEIN RS00775
gene id: 667014:THEIN_RS00775
uniprot id: F8A8Z0
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

667014:THEIN RS02195
gene id: 667014:THEIN_RS02195
uniprot id: F8AAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

667014:THEIN RS02090
gene id: 667014:THEIN_RS02090
uniprot id: F8AAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

667014:THEIN RS10960
gene id: 667014:THEIN_RS10960
uniprot id: F8ADN9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

667014:THEIN RS09350
gene id: 667014:THEIN_RS09350
uniprot id: F8ABZ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01590
gene id: 667014:THEIN_RS01590
uniprot id: F8A9Z1
names: Similarity
messages: Belongs to the MotB family.

667014:THEIN RS07780
gene id: 667014:THEIN_RS07780
uniprot id: F8AAG9
names: Similarity
messages: Belongs to the universal stress protein A family.

667014:THEIN RS07060
gene id: 667014:THEIN_RS07060
uniprot id: F8A985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

667014:THEIN RS11540
gene id: 667014:THEIN_RS11540
uniprot id: F8AD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemerythrin family.
messages: Membrane

667014:THEIN RS04200
gene id: 667014:THEIN_RS04200
uniprot id: F8ACK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

667014:THEIN RS09815
gene id: 667014:THEIN_RS09815
uniprot id: F8ACD8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS09620
gene id: 667014:THEIN_RS09620
uniprot id: F8ACA7
names: Similarity
messages: Belongs to the GSP E family.

667014:THEIN RS06705
gene id: 667014:THEIN_RS06705
uniprot id: F8A955
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

667014:THEIN RS00505
gene id: 667014:THEIN_RS00505
uniprot id: F8A8H6
names: Similarity
messages: Belongs to the peptidase M16 family.

667014:THEIN RS10720
gene id: 667014:THEIN_RS10720
uniprot id: F8ADD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

667014:THEIN RS04375
gene id: 667014:THEIN_RS04375
uniprot id: F8ACV1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

667014:THEIN RS08790
gene id: 667014:THEIN_RS08790
uniprot id: F8ABI6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

667014:THEIN RS01345
gene id: 667014:THEIN_RS01345
uniprot id: F8A9V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

667014:THEIN RS02760
gene id: 667014:THEIN_RS02760
uniprot id: F8ABC0
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05315
gene id: 667014:THEIN_RS05315
uniprot id: F8ADN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

667014:THEIN RS06955
gene id: 667014:THEIN_RS06955
uniprot id: F8A9K9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS06785
gene id: 667014:THEIN_RS06785
uniprot id: F8A980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

667014:THEIN RS01905
gene id: 667014:THEIN_RS01905
uniprot id: F8AAC2
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

667014:THEIN RS01730
gene id: 667014:THEIN_RS01730
uniprot id: F8AA88
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS02925
gene id: 667014:THEIN_RS02925
uniprot id: F8ABF0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

667014:THEIN RS10365
gene id: 667014:THEIN_RS10365
uniprot id: F8AD14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

667014:THEIN RS04430
gene id: 667014:THEIN_RS04430
uniprot id: F8ACW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS00685
gene id: 667014:THEIN_RS00685
uniprot id: F8A8X4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

667014:THEIN RS00445
gene id: 667014:THEIN_RS00445
uniprot id: F8A8G7
names: Similarity
messages: Belongs to the Skp family.

667014:THEIN RS05420
gene id: 667014:THEIN_RS05420
uniprot id: F8ADX2
names: Similarity
messages: Belongs to the ribF family.

667014:THEIN RS04585
gene id: 667014:THEIN_RS04585
uniprot id: F8AD49
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09670
gene id: 667014:THEIN_RS09670
uniprot id: F8A9R1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

667014:THEIN RS04445
gene id: 667014:THEIN_RS04445
uniprot id: F8A8B1
names: Similarity
messages: Belongs to the LOG family.

667014:THEIN RS00005
gene id: 667014:THEIN_RS00005
uniprot id: F8A7X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

667014:THEIN RS09640
gene id: 667014:THEIN_RS09640
uniprot id: F8ACB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

667014:THEIN RS06400
gene id: 667014:THEIN_RS06400
uniprot id: F8A8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

667014:THEIN RS03780
gene id: 667014:THEIN_RS03780
uniprot id: F8A8A2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

667014:THEIN RS07510
gene id: 667014:THEIN_RS07510
uniprot id: F8AA49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

667014:THEIN RS07710
gene id: 667014:THEIN_RS07710
uniprot id: F8AAF5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00410
gene id: 667014:THEIN_RS00410
uniprot id: F8A8G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

667014:THEIN RS11350
gene id: 667014:THEIN_RS11350
uniprot id: F8AE25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

667014:THEIN RS11180
gene id: 667014:THEIN_RS11180
uniprot id: F8ADS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

667014:THEIN RS08115
gene id: 667014:THEIN_RS08115
uniprot id: F8AAU0
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

667014:THEIN RS01325
gene id: 667014:THEIN_RS01325
uniprot id: F8A9U8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

667014:THEIN RS10695
gene id: 667014:THEIN_RS10695
uniprot id: F8ADC8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

667014:THEIN RS06950
gene id: 667014:THEIN_RS06950
uniprot id: F8A9K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

667014:THEIN RS03790
gene id: 667014:THEIN_RS03790
uniprot id: F8AC71
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

667014:THEIN RS08315
gene id: 667014:THEIN_RS08315
uniprot id: F8AAX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS06780
gene id: 667014:THEIN_RS06780
uniprot id: F8A966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

667014:THEIN RS01040
gene id: 667014:THEIN_RS01040
uniprot id: F8A9F1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

667014:THEIN RS07615
gene id: 667014:THEIN_RS07615
uniprot id: F8AAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS07890
gene id: 667014:THEIN_RS07890
uniprot id: F8AAI9
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS11485
gene id: 667014:THEIN_RS11485
uniprot id: F8A866
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

667014:THEIN RS11260
gene id: 667014:THEIN_RS11260
uniprot id: F8ADU2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

667014:THEIN RS09710
gene id: 667014:THEIN_RS09710
uniprot id: F8ACC1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

667014:THEIN RS04360
gene id: 667014:THEIN_RS04360
uniprot id: F8ACU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

667014:THEIN RS02835
gene id: 667014:THEIN_RS02835
uniprot id: F8ABD5
names: Similarity
messages: Belongs to the acylphosphatase family.

667014:THEIN RS04020
gene id: 667014:THEIN_RS04020
uniprot id: F8ACH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

667014:THEIN RS06315
gene id: 667014:THEIN_RS06315
uniprot id: F8A8M0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

667014:THEIN RS03650
gene id: 667014:THEIN_RS03650
uniprot id: F8AC50
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

667014:THEIN RS08290
gene id: 667014:THEIN_RS08290
uniprot id: F8A9A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS01925
gene id: 667014:THEIN_RS01925
uniprot id: F8AE62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00850
gene id: 667014:THEIN_RS00850
uniprot id: F8A904
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

667014:THEIN RS01245
gene id: 667014:THEIN_RS01245
uniprot id: F8AE51
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

667014:THEIN RS00510
gene id: 667014:THEIN_RS00510
uniprot id: F8A8H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

667014:THEIN RS05175
gene id: 667014:THEIN_RS05175
uniprot id: F8ADL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

667014:THEIN RS04600
gene id: 667014:THEIN_RS04600
uniprot id: F8AD52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

667014:THEIN RS06790
gene id: 667014:THEIN_RS06790
uniprot id: F8A967
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

667014:THEIN RS06990
gene id: 667014:THEIN_RS06990
uniprot id: F8A9L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

667014:THEIN RS10895
gene id: 667014:THEIN_RS10895
uniprot id: F8ADG7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS06700
gene id: 667014:THEIN_RS06700
uniprot id: F8A975
names: Similarity
messages: Belongs to the Nudix hydrolase family.

667014:THEIN RS04865
gene id: 667014:THEIN_RS04865
uniprot id: F8AD96
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS10390
gene id: 667014:THEIN_RS10390
uniprot id: F8A9S2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

667014:THEIN RS09490
gene id: 667014:THEIN_RS09490
uniprot id: F8AC82
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

667014:THEIN RS06675
gene id: 667014:THEIN_RS06675
uniprot id: F8A951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

667014:THEIN RS03525
gene id: 667014:THEIN_RS03525
uniprot id: F8AC24
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09255
gene id: 667014:THEIN_RS09255
uniprot id: F8ABY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

667014:THEIN RS07150
gene id: 667014:THEIN_RS07150
uniprot id: F8A9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

667014:THEIN RS05045
gene id: 667014:THEIN_RS05045
uniprot id: F8ADI9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07470
gene id: 667014:THEIN_RS07470
uniprot id: F8AA41
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

667014:THEIN RS06450
gene id: 667014:THEIN_RS06450
uniprot id: F8A8P4
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

667014:THEIN RS02320
gene id: 667014:THEIN_RS02320
uniprot id: F8AAR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

667014:THEIN RS04260
gene id: 667014:THEIN_RS04260
uniprot id: F8ACS7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

667014:THEIN RS03860
gene id: 667014:THEIN_RS03860
uniprot id: F8ACE5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

667014:THEIN RS05430
gene id: 667014:THEIN_RS05430
uniprot id: F8ADX4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

667014:THEIN RS03250
gene id: 667014:THEIN_RS03250
uniprot id: F8A887
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

667014:THEIN RS02200
gene id: 667014:THEIN_RS02200
uniprot id: F8AAP7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07500
gene id: 667014:THEIN_RS07500
uniprot id: F8AA47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

667014:THEIN RS10415
gene id: 667014:THEIN_RS10415
uniprot id: F8AD22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS01070
gene id: 667014:THEIN_RS01070
uniprot id: F8A9F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

667014:THEIN RS06875
gene id: 667014:THEIN_RS06875
uniprot id: F8A9J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

667014:THEIN RS05070
gene id: 667014:THEIN_RS05070
uniprot id: F8ADJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

667014:THEIN RS03440
gene id: 667014:THEIN_RS03440
uniprot id: F8A896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

667014:THEIN RS08130
gene id: 667014:THEIN_RS08130
uniprot id: F8AAU3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

667014:THEIN RS04300
gene id: 667014:THEIN_RS04300
uniprot id: F8ACT5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

667014:THEIN RS08570
gene id: 667014:THEIN_RS08570
uniprot id: F8AB84
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

667014:THEIN RS06555
gene id: 667014:THEIN_RS06555
uniprot id: F8A927
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

667014:THEIN RS00200
gene id: 667014:THEIN_RS00200
uniprot id: F8A8C0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

667014:THEIN RS09215
gene id: 667014:THEIN_RS09215
uniprot id: F8ABX4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

667014:THEIN RS07455
gene id: 667014:THEIN_RS07455
uniprot id: F8AA38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

667014:THEIN RS00180
gene id: 667014:THEIN_RS00180
uniprot id: F8A8B6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

667014:THEIN RS00840
gene id: 667014:THEIN_RS00840
uniprot id: F8A903
names: Similarity
messages: Belongs to the archease family.

667014:THEIN RS07915
gene id: 667014:THEIN_RS07915
uniprot id: F8AAJ3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

667014:THEIN RS08255
gene id: 667014:THEIN_RS08255
uniprot id: F8AAW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS07485
gene id: 667014:THEIN_RS07485
uniprot id: F8AA44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

667014:THEIN RS04345
gene id: 667014:THEIN_RS04345
uniprot id: F8ACU5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

667014:THEIN RS03660
gene id: 667014:THEIN_RS03660
uniprot id: F8AC52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

667014:THEIN RS10360
gene id: 667014:THEIN_RS10360
uniprot id: F8AD13
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05490
gene id: 667014:THEIN_RS05490
uniprot id: F8ADY6
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS01265
gene id: 667014:THEIN_RS01265
uniprot id: F8A9T6
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS00365
gene id: 667014:THEIN_RS00365
uniprot id: F8A8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

667014:THEIN RS02285
gene id: 667014:THEIN_RS02285
uniprot id: F8AAQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

667014:THEIN RS05185
gene id: 667014:THEIN_RS05185
uniprot id: F8ADL3
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS04305
gene id: 667014:THEIN_RS04305
uniprot id: F8ACT6
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS04440
gene id: 667014:THEIN_RS04440
uniprot id: F8ACW3
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07460
gene id: 667014:THEIN_RS07460
uniprot id: F8AA39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

667014:THEIN RS03735
gene id: 667014:THEIN_RS03735
uniprot id: F8AC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

667014:THEIN RS07450
gene id: 667014:THEIN_RS07450
uniprot id: F8AA37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

667014:THEIN RS06735
gene id: 667014:THEIN_RS06735
uniprot id: F8A958
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

667014:THEIN RS11080
gene id: 667014:THEIN_RS11080
uniprot id: F8ADR3
names: Similarity
messages: Belongs to the rubredoxin family.

667014:THEIN RS11305
gene id: 667014:THEIN_RS11305
uniprot id: F8ADV1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

667014:THEIN RS01480
gene id: 667014:THEIN_RS01480
uniprot id: F8AE54
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

667014:THEIN RS02945
gene id: 667014:THEIN_RS02945
uniprot id: F8ABF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

667014:THEIN RS01485
gene id: 667014:THEIN_RS01485
uniprot id: F8A9X4
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

667014:THEIN RS03430
gene id: 667014:THEIN_RS03430
uniprot id: F8ABV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

667014:THEIN RS09035
gene id: 667014:THEIN_RS09035
uniprot id: F8ABM9
names: Similarity
messages: Belongs to the UPF0235 family.

667014:THEIN RS01725
gene id: 667014:THEIN_RS01725
uniprot id: F8AA87
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

667014:THEIN RS07855
gene id: 667014:THEIN_RS07855
uniprot id: F8AAI3
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS03185
gene id: 667014:THEIN_RS03185
uniprot id: F8ABR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

667014:THEIN RS05615
gene id: 667014:THEIN_RS05615
uniprot id: F8AE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

667014:THEIN RS04330
gene id: 667014:THEIN_RS04330
uniprot id: F8ACU1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

667014:THEIN RS02875
gene id: 667014:THEIN_RS02875
uniprot id: F8ABE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07800
gene id: 667014:THEIN_RS07800
uniprot id: F8AAH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

667014:THEIN RS10495
gene id: 667014:THEIN_RS10495
uniprot id: F8AD33
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

667014:THEIN RS07495
gene id: 667014:THEIN_RS07495
uniprot id: F8AA46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

667014:THEIN RS04125
gene id: 667014:THEIN_RS04125
uniprot id: F8ACJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

667014:THEIN RS03345
gene id: 667014:THEIN_RS03345
uniprot id: F8ABT9
names: Similarity
messages: Belongs to the PstS family.

667014:THEIN RS04530
gene id: 667014:THEIN_RS04530
uniprot id: F8ACX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS07480
gene id: 667014:THEIN_RS07480
uniprot id: F8AA43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

667014:THEIN RS02725
gene id: 667014:THEIN_RS02725
uniprot id: F8ABB3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

667014:THEIN RS00050
gene id: 667014:THEIN_RS00050
uniprot id: F8A7Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

667014:THEIN RS11855
gene id: 667014:THEIN_RS11855
uniprot id: F8ADR8
names: Similarity
messages: Belongs to the PstS family.

667014:THEIN RS09345
gene id: 667014:THEIN_RS09345
uniprot id: F8A9Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

667014:THEIN RS00650
gene id: 667014:THEIN_RS00650
uniprot id: F8A8W7
names: Similarity
messages: Belongs to the fabD family.

667014:THEIN RS00205
gene id: 667014:THEIN_RS00205
uniprot id: F8A8C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

667014:THEIN RS02730
gene id: 667014:THEIN_RS02730
uniprot id: F8ABB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS05365
gene id: 667014:THEIN_RS05365
uniprot id: F8ADW1
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

667014:THEIN RS08595
gene id: 667014:THEIN_RS08595
uniprot id: F8AB88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

667014:THEIN RS05335
gene id: 667014:THEIN_RS05335
uniprot id: F8ADN5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-101 inactivates the nitrogenase reductase and regulates nitrogenase activity.

667014:THEIN RS05840
gene id: 667014:THEIN_RS05840
uniprot id: F8A824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

667014:THEIN RS09900
gene id: 667014:THEIN_RS09900
uniprot id: F8ACL8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

667014:THEIN RS05580
gene id: 667014:THEIN_RS05580
uniprot id: F8A8S3
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

667014:THEIN RS05650
gene id: 667014:THEIN_RS05650
uniprot id: F8AE13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

667014:THEIN RS05245
gene id: 667014:THEIN_RS05245
uniprot id: F8ADM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS04750
gene id: 667014:THEIN_RS04750
uniprot id: F8AD77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS07390
gene id: 667014:THEIN_RS07390
uniprot id: F8AA28
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

667014:THEIN RS11005
gene id: 667014:THEIN_RS11005
uniprot id: F8ADP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

667014:THEIN RS07960
gene id: 667014:THEIN_RS07960
uniprot id: F8AAJ9
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS04745
gene id: 667014:THEIN_RS04745
uniprot id: F8AD76
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS03140
gene id: 667014:THEIN_RS03140
uniprot id: F8ABQ3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

667014:THEIN RS01200
gene id: 667014:THEIN_RS01200
uniprot id: F8A9H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS10580
gene id: 667014:THEIN_RS10580
uniprot id: F8ADA8
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

667014:THEIN RS10905
gene id: 667014:THEIN_RS10905
uniprot id: F8A9T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

667014:THEIN RS00935
gene id: 667014:THEIN_RS00935
uniprot id: F8A9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

667014:THEIN RS07575
gene id: 667014:THEIN_RS07575
uniprot id: F8AA61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

667014:THEIN RS02575
gene id: 667014:THEIN_RS02575
uniprot id: F8AB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

667014:THEIN RS07795
gene id: 667014:THEIN_RS07795
uniprot id: F8AAH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

667014:THEIN RS11325
gene id: 667014:THEIN_RS11325
uniprot id: F8ADV5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

667014:THEIN RS11010
gene id: 667014:THEIN_RS11010
uniprot id: F8ADP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

667014:THEIN RS02390
gene id: 667014:THEIN_RS02390
uniprot id: F8AAZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

667014:THEIN RS11530
gene id: 667014:THEIN_RS11530
uniprot id: F8ACS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

667014:THEIN RS05610
gene id: 667014:THEIN_RS05610
uniprot id: F8AE06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

667014:THEIN RS09770
gene id: 667014:THEIN_RS09770
uniprot id: F8ACD1
names: Similarity
messages: Belongs to the HypE family.

667014:THEIN RS00355
gene id: 667014:THEIN_RS00355
uniprot id: F8A8F1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

667014:THEIN RS09460
gene id: 667014:THEIN_RS09460
uniprot id: F8AC76
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS06125
gene id: 667014:THEIN_RS06125
uniprot id: F8A8I5
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

667014:THEIN RS01550
gene id: 667014:THEIN_RS01550
uniprot id: F8A9Y5
names: Similarity
messages: Belongs to the aspartokinase family.

667014:THEIN RS03310
gene id: 667014:THEIN_RS03310
uniprot id: F8ABT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

667014:THEIN RS07910
gene id: 667014:THEIN_RS07910
uniprot id: F8AAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

667014:THEIN RS10130
gene id: 667014:THEIN_RS10130
uniprot id: F8A9S0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS10915
gene id: 667014:THEIN_RS10915
uniprot id: F8A9T3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

667014:THEIN RS07715
gene id: 667014:THEIN_RS07715
uniprot id: F8AAF6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

667014:THEIN RS06540
gene id: 667014:THEIN_RS06540
uniprot id: F8A924
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

667014:THEIN RS06185
gene id: 667014:THEIN_RS06185
uniprot id: F8A8J6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Belongs to the GARS family.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

667014:THEIN RS08305
gene id: 667014:THEIN_RS08305
uniprot id: F8A9A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS02930
gene id: 667014:THEIN_RS02930
uniprot id: F8ABF1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

667014:THEIN RS02220
gene id: 667014:THEIN_RS02220
uniprot id: F8AAQ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

667014:THEIN RS00485
gene id: 667014:THEIN_RS00485
uniprot id: F8A8H3
names: Similarity
messages: Belongs to the Fur family.

667014:THEIN RS07465
gene id: 667014:THEIN_RS07465
uniprot id: F8AA40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

667014:THEIN RS07435
gene id: 667014:THEIN_RS07435
uniprot id: F8AA34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

667014:THEIN RS02240
gene id: 667014:THEIN_RS02240
uniprot id: F8AAQ4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

667014:THEIN RS10800
gene id: 667014:THEIN_RS10800
uniprot id: F8ADE8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

667014:THEIN RS05240
gene id: 667014:THEIN_RS05240
uniprot id: F8A8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

667014:THEIN RS06645
gene id: 667014:THEIN_RS06645
uniprot id: F8A945
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

667014:THEIN RS08610
gene id: 667014:THEIN_RS08610
uniprot id: F8AB91
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

667014:THEIN RS08125
gene id: 667014:THEIN_RS08125
uniprot id: F8AAU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

667014:THEIN RS10975
gene id: 667014:THEIN_RS10975
uniprot id: F8ADP2
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS11395
gene id: 667014:THEIN_RS11395
uniprot id: F8AE34
names: Similarity
messages: Belongs to the CutA family.

667014:THEIN RS09730
gene id: 667014:THEIN_RS09730
uniprot id: F8ACC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS07245
gene id: 667014:THEIN_RS07245
uniprot id: F8AA04
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

667014:THEIN RS00065
gene id: 667014:THEIN_RS00065
uniprot id: F8A7Y3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

667014:THEIN RS03830
gene id: 667014:THEIN_RS03830
uniprot id: F8ACD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS11840
gene id: 667014:THEIN_RS11840
uniprot id: F8ADC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

667014:THEIN RS02160
gene id: 667014:THEIN_RS02160
uniprot id: F8AAP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

667014:THEIN RS10585
gene id: 667014:THEIN_RS10585
uniprot id: F8ADA9
names: Similarity
messages: Belongs to the hemerythrin family.

667014:THEIN RS02110
gene id: 667014:THEIN_RS02110
uniprot id: F8AAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

667014:THEIN RS11365
gene id: 667014:THEIN_RS11365
uniprot id: F8AE28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

667014:THEIN RS05890
gene id: 667014:THEIN_RS05890
uniprot id: F8A832
names: Similarity
messages: Belongs to the peptidase M24B family.

667014:THEIN RS07360
gene id: 667014:THEIN_RS07360
uniprot id: F8AA22
names: Similarity
messages: Belongs to the creatininase superfamily.

667014:THEIN RS02980
gene id: 667014:THEIN_RS02980
uniprot id: F8ABG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS06360
gene id: 667014:THEIN_RS06360
uniprot id: F8A8M8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

667014:THEIN RS04570
gene id: 667014:THEIN_RS04570
uniprot id: F8AD46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

667014:THEIN RS10195
gene id: 667014:THEIN_RS10195
uniprot id: F8ACY4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

667014:THEIN RS03255
gene id: 667014:THEIN_RS03255
uniprot id: F8ABS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

667014:THEIN RS10200
gene id: 667014:THEIN_RS10200
uniprot id: F8ACY5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

667014:THEIN RS03260
gene id: 667014:THEIN_RS03260
uniprot id: F8ABS6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS10515
gene id: 667014:THEIN_RS10515
uniprot id: F8AD37
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

667014:THEIN RS09795
gene id: 667014:THEIN_RS09795
uniprot id: F8ACD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

667014:THEIN RS02180
gene id: 667014:THEIN_RS02180
uniprot id: F8AE64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00745
gene id: 667014:THEIN_RS00745
uniprot id: F8A8Y6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

667014:THEIN RS02515
gene id: 667014:THEIN_RS02515
uniprot id: F8AB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

667014:THEIN RS01230
gene id: 667014:THEIN_RS01230
uniprot id: F8A9I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

667014:THEIN RS07445
gene id: 667014:THEIN_RS07445
uniprot id: F8AA36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

667014:THEIN RS10410
gene id: 667014:THEIN_RS10410
uniprot id: F8AD21
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

667014:THEIN RS01410
gene id: 667014:THEIN_RS01410
uniprot id: F8A9W4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

667014:THEIN RS01920
gene id: 667014:THEIN_RS01920
uniprot id: F8AAC5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

667014:THEIN RS09375
gene id: 667014:THEIN_RS09375
uniprot id: F8ABZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

667014:THEIN RS11040
gene id: 667014:THEIN_RS11040
uniprot id: F8ADQ5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

667014:THEIN RS01610
gene id: 667014:THEIN_RS01610
uniprot id: F8A9Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

667014:THEIN RS03435
gene id: 667014:THEIN_RS03435
uniprot id: F8ABV1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

667014:THEIN RS07105
gene id: 667014:THEIN_RS07105
uniprot id: F8A9N3
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

667014:THEIN RS06945
gene id: 667014:THEIN_RS06945
uniprot id: F8A9K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS03895
gene id: 667014:THEIN_RS03895
uniprot id: F8ACF2
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS08345
gene id: 667014:THEIN_RS08345
uniprot id: F8AAX9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

667014:THEIN RS00635
gene id: 667014:THEIN_RS00635
uniprot id: F8A8W4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

667014:THEIN RS10340
gene id: 667014:THEIN_RS10340
uniprot id: F8AD09
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

667014:THEIN RS07000
gene id: 667014:THEIN_RS07000
uniprot id: F8A9L7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS10330
gene id: 667014:THEIN_RS10330
uniprot id: F8AD07
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS11505
gene id: 667014:THEIN_RS11505
uniprot id: F8ABS9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

667014:THEIN RS06720
gene id: 667014:THEIN_RS06720
uniprot id: F8A977
names: Similarity
messages: Belongs to the hemerythrin family.

667014:THEIN RS00855
gene id: 667014:THEIN_RS00855
uniprot id: F8A905
names: Similarity
messages: Belongs to the peptidase S16 family.

667014:THEIN RS06280
gene id: 667014:THEIN_RS06280
uniprot id: F8A8L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

667014:THEIN RS07530
gene id: 667014:THEIN_RS07530
uniprot id: F8AA53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

667014:THEIN RS02155
gene id: 667014:THEIN_RS02155
uniprot id: F8AAN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

667014:THEIN RS03655
gene id: 667014:THEIN_RS03655
uniprot id: F8AC51
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

667014:THEIN RS09005
gene id: 667014:THEIN_RS09005
uniprot id: F8ABM3
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS01010
gene id: 667014:THEIN_RS01010
uniprot id: F8A9E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

667014:THEIN RS04225
gene id: 667014:THEIN_RS04225
uniprot id: F8ACS0
names: Similarity
messages: Belongs to the ComB family.

667014:THEIN RS06685
gene id: 667014:THEIN_RS06685
uniprot id: F8A953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

667014:THEIN RS04045
gene id: 667014:THEIN_RS04045
uniprot id: F8ACH9
names: Similarity
messages: Belongs to the MEMO1 family.

667014:THEIN RS11025
gene id: 667014:THEIN_RS11025
uniprot id: F8ADQ2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

667014:THEIN RS03230
gene id: 667014:THEIN_RS03230
uniprot id: F8ABS1
names: Similarity
messages: Belongs to the UPF0102 family.

667014:THEIN RS09570
gene id: 667014:THEIN_RS09570
uniprot id: F8AC97
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

667014:THEIN RS11300
gene id: 667014:THEIN_RS11300
uniprot id: F8ADV0
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

667014:THEIN RS02025
gene id: 667014:THEIN_RS02025
uniprot id: F8AAL2
names: Similarity
messages: Belongs to the threonine synthase family.

667014:THEIN RS11355
gene id: 667014:THEIN_RS11355
uniprot id: F8AE26
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

667014:THEIN RS06250
gene id: 667014:THEIN_RS06250
uniprot id: F8A8K9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

667014:THEIN RS11575
gene id: 667014:THEIN_RS11575
uniprot id: F8ADX6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

667014:THEIN RS04875
gene id: 667014:THEIN_RS04875
uniprot id: F8AD97
names: Similarity
messages: Belongs to the class-I fumarase family.

667014:THEIN RS06575
gene id: 667014:THEIN_RS06575
uniprot id: F8A931
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

667014:THEIN RS02480
gene id: 667014:THEIN_RS02480
uniprot id: F8AB12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

667014:THEIN RS05340
gene id: 667014:THEIN_RS05340
uniprot id: F8ADN6
names: Similarity
messages: Belongs to the P(II) protein family.

667014:THEIN RS05040
gene id: 667014:THEIN_RS05040
uniprot id: F8ADI8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

667014:THEIN RS10725
gene id: 667014:THEIN_RS10725
uniprot id: F8ADD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS06615
gene id: 667014:THEIN_RS06615
uniprot id: F8A939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

667014:THEIN RS03835
gene id: 667014:THEIN_RS03835
uniprot id: F8ACE0
names: Similarity
messages: Belongs to the TlyA family.

667014:THEIN RS09355
gene id: 667014:THEIN_RS09355
uniprot id: F8A9Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

667014:THEIN RS02695
gene id: 667014:THEIN_RS02695
uniprot id: F8A877
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

667014:THEIN RS00630
gene id: 667014:THEIN_RS00630
uniprot id: F8A8W3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

667014:THEIN RS10560
gene id: 667014:THEIN_RS10560
uniprot id: F8AD44
names: Similarity
messages: Belongs to the HdrA family.

667014:THEIN RS00145
gene id: 667014:THEIN_RS00145
uniprot id: F8A7Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS09590
gene id: 667014:THEIN_RS09590
uniprot id: F8ACA1
names: Similarity
messages: Belongs to the bacterial secretin family.

667014:THEIN RS09890
gene id: 667014:THEIN_RS09890
uniprot id: F8ACL6
names: Similarity
messages: Belongs to the peptidase S26 family.

667014:THEIN RS04790
gene id: 667014:THEIN_RS04790
uniprot id: F8AD84
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

667014:THEIN RS08440
gene id: 667014:THEIN_RS08440
uniprot id: F8AB59
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS04490
gene id: 667014:THEIN_RS04490
uniprot id: F8ACX0
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

667014:THEIN RS02635
gene id: 667014:THEIN_RS02635
uniprot id: F8AB36
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

667014:THEIN RS00750
gene id: 667014:THEIN_RS00750
uniprot id: F8A8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

667014:THEIN RS05970
gene id: 667014:THEIN_RS05970
uniprot id: F8A846
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

667014:THEIN RS07570
gene id: 667014:THEIN_RS07570
uniprot id: F8AA60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

667014:THEIN RS00470
gene id: 667014:THEIN_RS00470
uniprot id: F8A8H1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

667014:THEIN RS00590
gene id: 667014:THEIN_RS00590
uniprot id: F8A8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS03095
gene id: 667014:THEIN_RS03095
uniprot id: F8ABP4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

667014:THEIN RS06325
gene id: 667014:THEIN_RS06325
uniprot id: F8A8M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

667014:THEIN RS08625
gene id: 667014:THEIN_RS08625
uniprot id: F8AB93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

667014:THEIN RS02735
gene id: 667014:THEIN_RS02735
uniprot id: F8ABB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS00765
gene id: 667014:THEIN_RS00765
uniprot id: F8AE43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

667014:THEIN RS07175
gene id: 667014:THEIN_RS07175
uniprot id: F8A989
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

667014:THEIN RS08635
gene id: 667014:THEIN_RS08635
uniprot id: F8AB94
names: Similarity
messages: Belongs to the UPF0045 family.

667014:THEIN RS00085
gene id: 667014:THEIN_RS00085
uniprot id: F8A7Y7
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

667014:THEIN RS10455
gene id: 667014:THEIN_RS10455
uniprot id: F8AD27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

667014:THEIN RS01685
gene id: 667014:THEIN_RS01685
uniprot id: F8AA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS03965
gene id: 667014:THEIN_RS03965
uniprot id: F8ACG5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

667014:THEIN RS00285
gene id: 667014:THEIN_RS00285
uniprot id: F8A8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

667014:THEIN RS01895
gene id: 667014:THEIN_RS01895
uniprot id: F8AAC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

667014:THEIN RS05190
gene id: 667014:THEIN_RS05190
uniprot id: F8ADL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

667014:THEIN RS01820
gene id: 667014:THEIN_RS01820
uniprot id: F8AAA6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS08455
gene id: 667014:THEIN_RS08455
uniprot id: F8AB62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS01060
gene id: 667014:THEIN_RS01060
uniprot id: F8A9F5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

667014:THEIN RS11805
gene id: 667014:THEIN_RS11805
uniprot id: F8A9S5
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

667014:THEIN RS05515
gene id: 667014:THEIN_RS05515
uniprot id: F8ADZ1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

667014:THEIN RS00910
gene id: 667014:THEIN_RS00910
uniprot id: F8A9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

667014:THEIN RS09185
gene id: 667014:THEIN_RS09185
uniprot id: F8ABW8
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

667014:THEIN RS04595
gene id: 667014:THEIN_RS04595
uniprot id: F8AD51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS07180
gene id: 667014:THEIN_RS07180
uniprot id: F8A9P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

667014:THEIN RS01700
gene id: 667014:THEIN_RS01700
uniprot id: F8AA80
names: Similarity
messages: Belongs to the universal stress protein A family.

667014:THEIN RS03025
gene id: 667014:THEIN_RS03025
uniprot id: F8ABG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

667014:THEIN RS07260
gene id: 667014:THEIN_RS07260
uniprot id: F8AA07
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

667014:THEIN RS07505
gene id: 667014:THEIN_RS07505
uniprot id: F8AA48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

667014:THEIN RS08600
gene id: 667014:THEIN_RS08600
uniprot id: F8AB89
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

667014:THEIN RS01810
gene id: 667014:THEIN_RS01810
uniprot id: F8AAA4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

667014:THEIN RS01815
gene id: 667014:THEIN_RS01815
uniprot id: F8AAA5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

667014:THEIN RS10355
gene id: 667014:THEIN_RS10355
uniprot id: F8AD12
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

667014:THEIN RS06305
gene id: 667014:THEIN_RS06305
uniprot id: F8A8L8
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

667014:THEIN RS05485
gene id: 667014:THEIN_RS05485
uniprot id: F8ADY5
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09505
gene id: 667014:THEIN_RS09505
uniprot id: F8AC85
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS08740
gene id: 667014:THEIN_RS08740
uniprot id: F8ABB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

667014:THEIN RS06320
gene id: 667014:THEIN_RS06320
uniprot id: F8A8T9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

667014:THEIN RS08845
gene id: 667014:THEIN_RS08845
uniprot id: F8ABJ7
names: Similarity
messages: Belongs to the asparagine synthetase family.

667014:THEIN RS08095
gene id: 667014:THEIN_RS08095
uniprot id: F8AAT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

667014:THEIN RS08140
gene id: 667014:THEIN_RS08140
uniprot id: F8AAU5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

667014:THEIN RS09295
gene id: 667014:THEIN_RS09295
uniprot id: F8ABY9
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09025
gene id: 667014:THEIN_RS09025
uniprot id: F8ABM7
names: Similarity
messages: Belongs to the YggT family.

667014:THEIN RS01505
gene id: 667014:THEIN_RS01505
uniprot id: F8AE55
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

667014:THEIN RS01020
gene id: 667014:THEIN_RS01020
uniprot id: F8A9E7
names: Similarity
messages: Belongs to the P(II) protein family.

667014:THEIN RS06295
gene id: 667014:THEIN_RS06295
uniprot id: F8A8T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

667014:THEIN RS10685
gene id: 667014:THEIN_RS10685
uniprot id: F8ADC6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS03980
gene id: 667014:THEIN_RS03980
uniprot id: F8ACG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

667014:THEIN RS04820
gene id: 667014:THEIN_RS04820
uniprot id: F8AD89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01035
gene id: 667014:THEIN_RS01035
uniprot id: F8A9F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

667014:THEIN RS00870
gene id: 667014:THEIN_RS00870
uniprot id: F8A908
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

667014:THEIN RS07040
gene id: 667014:THEIN_RS07040
uniprot id: F8A984
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

667014:THEIN RS02890
gene id: 667014:THEIN_RS02890
uniprot id: F8ABE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

667014:THEIN RS00920
gene id: 667014:THEIN_RS00920
uniprot id: F8A9C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

667014:THEIN RS04100
gene id: 667014:THEIN_RS04100
uniprot id: F8ACI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

667014:THEIN RS07025
gene id: 667014:THEIN_RS07025
uniprot id: F8A983
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

667014:THEIN RS01000
gene id: 667014:THEIN_RS01000
uniprot id: F8A9E3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

667014:THEIN RS08135
gene id: 667014:THEIN_RS08135
uniprot id: F8AAU4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

667014:THEIN RS03240
gene id: 667014:THEIN_RS03240
uniprot id: F8ABS3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

667014:THEIN RS10550
gene id: 667014:THEIN_RS10550
uniprot id: F8AD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS02965
gene id: 667014:THEIN_RS02965
uniprot id: F8ABF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS11065
gene id: 667014:THEIN_RS11065
uniprot id: F8ADR0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

667014:THEIN RS01165
gene id: 667014:THEIN_RS01165
uniprot id: F8A9H1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

667014:THEIN RS00600
gene id: 667014:THEIN_RS00600
uniprot id: F8A8V8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

667014:THEIN RS09465
gene id: 667014:THEIN_RS09465
uniprot id: F8AC77
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS00250
gene id: 667014:THEIN_RS00250
uniprot id: F8A8D0
names: Similarity
messages: Belongs to the GPI family.

667014:THEIN RS10830
gene id: 667014:THEIN_RS10830
uniprot id: F8ADF5
names: Similarity
messages: Belongs to the TrpF family.

667014:THEIN RS02335
gene id: 667014:THEIN_RS02335
uniprot id: F8AAR5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

667014:THEIN RS00030
gene id: 667014:THEIN_RS00030
uniprot id: F8A7X6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00865
gene id: 667014:THEIN_RS00865
uniprot id: F8A907
names: Similarity
messages: Belongs to the Ahb/Nir family.

667014:THEIN RS03055
gene id: 667014:THEIN_RS03055
uniprot id: F8ABH2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS08535
gene id: 667014:THEIN_RS08535
uniprot id: F8AB77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

667014:THEIN RS10760
gene id: 667014:THEIN_RS10760
uniprot id: F8ADE1
names: Similarity
messages: Belongs to the AOR/FOR family.

667014:THEIN RS04565
gene id: 667014:THEIN_RS04565
uniprot id: F8ACY3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

667014:THEIN RS08575
gene id: 667014:THEIN_RS08575
uniprot id: F8A9B1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

667014:THEIN RS04975
gene id: 667014:THEIN_RS04975
uniprot id: F8ADH5
names: Similarity
messages: Belongs to the ParB family.

667014:THEIN RS03750
gene id: 667014:THEIN_RS03750
uniprot id: F8AC67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

667014:THEIN RS02665
gene id: 667014:THEIN_RS02665
uniprot id: F8AB41
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

667014:THEIN RS03725
gene id: 667014:THEIN_RS03725
uniprot id: F8AC63
names: Similarity
messages: Belongs to the archaeal ATPase family.

667014:THEIN RS07790
gene id: 667014:THEIN_RS07790
uniprot id: F8AAH1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

667014:THEIN RS05895
gene id: 667014:THEIN_RS05895
uniprot id: F8A833
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS06640
gene id: 667014:THEIN_RS06640
uniprot id: F8A944
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS10480
gene id: 667014:THEIN_RS10480
uniprot id: F8A9S7
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

667014:THEIN RS00140
gene id: 667014:THEIN_RS00140
uniprot id: F8A7Z7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS04285
gene id: 667014:THEIN_RS04285
uniprot id: F8ACT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

667014:THEIN RS10680
gene id: 667014:THEIN_RS10680
uniprot id: F8ADC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

667014:THEIN RS07515
gene id: 667014:THEIN_RS07515
uniprot id: F8AA50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

667014:THEIN RS08370
gene id: 667014:THEIN_RS08370
uniprot id: F8AAY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

667014:THEIN RS03670
gene id: 667014:THEIN_RS03670
uniprot id: F8AC54
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

667014:THEIN RS03640
gene id: 667014:THEIN_RS03640
uniprot id: F8AC48
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

667014:THEIN RS09615
gene id: 667014:THEIN_RS09615
uniprot id: F8ACA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

667014:THEIN RS09510
gene id: 667014:THEIN_RS09510
uniprot id: F8AC86
names: Similarity
messages: Belongs to the Nudix hydrolase family.

667014:THEIN RS10775
gene id: 667014:THEIN_RS10775
uniprot id: F8ADE4
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

667014:THEIN RS06610
gene id: 667014:THEIN_RS06610
uniprot id: F8A938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

667014:THEIN RS07155
gene id: 667014:THEIN_RS07155
uniprot id: F8A9P2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

667014:THEIN RS10875
gene id: 667014:THEIN_RS10875
uniprot id: F8ADG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS02905
gene id: 667014:THEIN_RS02905
uniprot id: F8ABE8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

667014:THEIN RS04550
gene id: 667014:THEIN_RS04550
uniprot id: F8ACY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

667014:THEIN RS10135
gene id: 667014:THEIN_RS10135
uniprot id: F8ACQ7
names: Similarity
messages: Belongs to the UPF0047 family.

667014:THEIN RS01515
gene id: 667014:THEIN_RS01515
uniprot id: F8A9X9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

667014:THEIN RS05110
gene id: 667014:THEIN_RS05110
uniprot id: F8ADK2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

667014:THEIN RS02410
gene id: 667014:THEIN_RS02410
uniprot id: F8AAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

667014:THEIN RS05050
gene id: 667014:THEIN_RS05050
uniprot id: F8ADJ0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

667014:THEIN RS05345
gene id: 667014:THEIN_RS05345
uniprot id: F8ADV7
names: Similarity
messages: Belongs to the P(II) protein family.

667014:THEIN RS04325
gene id: 667014:THEIN_RS04325
uniprot id: F8ACU0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS05460
gene id: 667014:THEIN_RS05460
uniprot id: F8ADY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

667014:THEIN RS04230
gene id: 667014:THEIN_RS04230
uniprot id: F8ACS1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS04610
gene id: 667014:THEIN_RS04610
uniprot id: F8AD53
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

667014:THEIN RS08965
gene id: 667014:THEIN_RS08965
uniprot id: F8ABL6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

667014:THEIN RS04295
gene id: 667014:THEIN_RS04295
uniprot id: F8ACT4
names: Similarity
messages: Belongs to the Ahb/Nir family.

667014:THEIN RS07725
gene id: 667014:THEIN_RS07725
uniprot id: F8AAF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

667014:THEIN RS01780
gene id: 667014:THEIN_RS01780
uniprot id: F8AA98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

667014:THEIN RS08120
gene id: 667014:THEIN_RS08120
uniprot id: F8AAU1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS06095
gene id: 667014:THEIN_RS06095
uniprot id: F8A862
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

667014:THEIN RS10370
gene id: 667014:THEIN_RS10370
uniprot id: F8AD15
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

667014:THEIN RS00240
gene id: 667014:THEIN_RS00240
uniprot id: F8A8C8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

667014:THEIN RS02660
gene id: 667014:THEIN_RS02660
uniprot id: F8A876
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

667014:THEIN RS05865
gene id: 667014:THEIN_RS05865
uniprot id: F8A829
names: Similarity
messages: Belongs to the thioredoxin family.

667014:THEIN RS04810
gene id: 667014:THEIN_RS04810
uniprot id: F8AD87
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

667014:THEIN RS05320
gene id: 667014:THEIN_RS05320
uniprot id: F8ADN2
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

667014:THEIN RS01400
gene id: 667014:THEIN_RS01400
uniprot id: F8A9W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

667014:THEIN RS00655
gene id: 667014:THEIN_RS00655
uniprot id: F8A8W8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

667014:THEIN RS02715
gene id: 667014:THEIN_RS02715
uniprot id: F8AB48
names: Similarity
messages: Belongs to the heat shock protein 70 family.

667014:THEIN RS03520
gene id: 667014:THEIN_RS03520
uniprot id: F8AC23
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09520
gene id: 667014:THEIN_RS09520
uniprot id: F8AC88
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS08880
gene id: 667014:THEIN_RS08880
uniprot id: F8ABK4
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS06530
gene id: 667014:THEIN_RS06530
uniprot id: F8A922
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS00945
gene id: 667014:THEIN_RS00945
uniprot id: F8A9D2
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

667014:THEIN RS00320
gene id: 667014:THEIN_RS00320
uniprot id: F8A8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS00735
gene id: 667014:THEIN_RS00735
uniprot id: F8A8Y4
names: Similarity
messages: Belongs to the peptidase S49 family.

667014:THEIN RS07425
gene id: 667014:THEIN_RS07425
uniprot id: F8AA32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

667014:THEIN RS06525
gene id: 667014:THEIN_RS06525
uniprot id: F8A921
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

667014:THEIN RS01335
gene id: 667014:THEIN_RS01335
uniprot id: F8A9V0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

667014:THEIN RS08100
gene id: 667014:THEIN_RS08100
uniprot id: F8AAT8
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05470
gene id: 667014:THEIN_RS05470
uniprot id: F8ADY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

667014:THEIN RS10190
gene id: 667014:THEIN_RS10190
uniprot id: F8ACR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

667014:THEIN RS00420
gene id: 667014:THEIN_RS00420
uniprot id: F8A8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

667014:THEIN RS02175
gene id: 667014:THEIN_RS02175
uniprot id: F8AAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

667014:THEIN RS07945
gene id: 667014:THEIN_RS07945
uniprot id: F8A9A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

667014:THEIN RS00195
gene id: 667014:THEIN_RS00195
uniprot id: F8A8B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

667014:THEIN RS04665
gene id: 667014:THEIN_RS04665
uniprot id: F8AD63
names: Similarity
messages: Belongs to the glutamate synthase family.

667014:THEIN RS07520
gene id: 667014:THEIN_RS07520
uniprot id: F8AA51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

667014:THEIN RS08580
gene id: 667014:THEIN_RS08580
uniprot id: F8AB85
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS08235
gene id: 667014:THEIN_RS08235
uniprot id: F8AAW3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00120
gene id: 667014:THEIN_RS00120
uniprot id: F8A7Z4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

667014:THEIN RS10185
gene id: 667014:THEIN_RS10185
uniprot id: F8ACR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

667014:THEIN RS09385
gene id: 667014:THEIN_RS09385
uniprot id: F8AC01
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

667014:THEIN RS09225
gene id: 667014:THEIN_RS09225
uniprot id: F8ABX6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

667014:THEIN RS07765
gene id: 667014:THEIN_RS07765
uniprot id: F8AAG6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-58 and Arg-61) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

667014:THEIN RS05780
gene id: 667014:THEIN_RS05780
uniprot id: F8A813
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01845
gene id: 667014:THEIN_RS01845
uniprot id: F8AAB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

667014:THEIN RS02800
gene id: 667014:THEIN_RS02800
uniprot id: F8ABC8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

667014:THEIN RS07405
gene id: 667014:THEIN_RS07405
uniprot id: F8AA30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

667014:THEIN RS06090
gene id: 667014:THEIN_RS06090
uniprot id: F8A861
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

667014:THEIN RS04130
gene id: 667014:THEIN_RS04130
uniprot id: F8ACJ4
names: Subcellular Location Annotation
messages: Mitochondrion

667014:THEIN RS00280
gene id: 667014:THEIN_RS00280
uniprot id: F8A8D6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

667014:THEIN RS01855
gene id: 667014:THEIN_RS01855
uniprot id: F8AAB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

667014:THEIN RS09370
gene id: 667014:THEIN_RS09370
uniprot id: F8ABZ8
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

667014:THEIN RS01940
gene id: 667014:THEIN_RS01940
uniprot id: F8AAC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS11225
gene id: 667014:THEIN_RS11225
uniprot id: F8ADT8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

667014:THEIN RS10950
gene id: 667014:THEIN_RS10950
uniprot id: F8ADN7
names: Similarity
messages: Belongs to the peptidase S41A family.

667014:THEIN RS05160
gene id: 667014:THEIN_RS05160
uniprot id: F8ADL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

667014:THEIN RS02600
gene id: 667014:THEIN_RS02600
uniprot id: F8AB29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

667014:THEIN RS04395
gene id: 667014:THEIN_RS04395
uniprot id: F8ACV3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

667014:THEIN RS04150
gene id: 667014:THEIN_RS04150
uniprot id: F8ACJ8
names: Similarity
messages: Belongs to the CFA/CMAS family.

667014:THEIN RS05685
gene id: 667014:THEIN_RS05685
uniprot id: F8A8S6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

667014:THEIN RS05730
gene id: 667014:THEIN_RS05730
uniprot id: F8AB52
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

667014:THEIN RS11265
gene id: 667014:THEIN_RS11265
uniprot id: F8ADU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

667014:THEIN RS10520
gene id: 667014:THEIN_RS10520
uniprot id: F8AD38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

667014:THEIN RS06165
gene id: 667014:THEIN_RS06165
uniprot id: F8A8J2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

667014:THEIN RS01915
gene id: 667014:THEIN_RS01915
uniprot id: F8AAC4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

667014:THEIN RS08085
gene id: 667014:THEIN_RS08085
uniprot id: F8AAT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

667014:THEIN RS06620
gene id: 667014:THEIN_RS06620
uniprot id: F8A940
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS05165
gene id: 667014:THEIN_RS05165
uniprot id: F8ADL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

667014:THEIN RS01545
gene id: 667014:THEIN_RS01545
uniprot id: F8AE56
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

667014:THEIN RS10965
gene id: 667014:THEIN_RS10965
uniprot id: F8ADP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

667014:THEIN RS04765
gene id: 667014:THEIN_RS04765
uniprot id: F8AD80
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

667014:THEIN RS03035
gene id: 667014:THEIN_RS03035
uniprot id: F8A883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS04320
gene id: 667014:THEIN_RS04320
uniprot id: F8ACT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

667014:THEIN RS10900
gene id: 667014:THEIN_RS10900
uniprot id: F8ADG8
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS03775
gene id: 667014:THEIN_RS03775
uniprot id: F8AC70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

667014:THEIN RS03105
gene id: 667014:THEIN_RS03105
uniprot id: F8ABP6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

667014:THEIN RS01050
gene id: 667014:THEIN_RS01050
uniprot id: F8A9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

667014:THEIN RS05980
gene id: 667014:THEIN_RS05980
uniprot id: F8A848
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

667014:THEIN RS10805
gene id: 667014:THEIN_RS10805
uniprot id: F8ADE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

667014:THEIN RS02605
gene id: 667014:THEIN_RS02605
uniprot id: F8AB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

667014:THEIN RS02775
gene id: 667014:THEIN_RS02775
uniprot id: F8ABC3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

667014:THEIN RS01695
gene id: 667014:THEIN_RS01695
uniprot id: F8AA79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS00930
gene id: 667014:THEIN_RS00930
uniprot id: F8A9C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

667014:THEIN RS01260
gene id: 667014:THEIN_RS01260
uniprot id: F8AE52
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS00220
gene id: 667014:THEIN_RS00220
uniprot id: F8A8C4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS04580
gene id: 667014:THEIN_RS04580
uniprot id: F8AD48
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS02190
gene id: 667014:THEIN_RS02190
uniprot id: F8AAP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS11230
gene id: 667014:THEIN_RS11230
uniprot id: F8ADT9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

667014:THEIN RS07580
gene id: 667014:THEIN_RS07580
uniprot id: F8A994
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

667014:THEIN RS10925
gene id: 667014:THEIN_RS10925
uniprot id: F8ADH1
names: Similarity
messages: Belongs to the GSP E family.

667014:THEIN RS04500
gene id: 667014:THEIN_RS04500
uniprot id: F8ACX2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

667014:THEIN RS07565
gene id: 667014:THEIN_RS07565
uniprot id: F8A993
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

667014:THEIN RS03575
gene id: 667014:THEIN_RS03575
uniprot id: F8AC34
names: Similarity
messages: Belongs to the asparagine synthetase family.

667014:THEIN RS05350
gene id: 667014:THEIN_RS05350
uniprot id: F8ADV8
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

667014:THEIN RS01255
gene id: 667014:THEIN_RS01255
uniprot id: F8A9I4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

667014:THEIN RS05510
gene id: 667014:THEIN_RS05510
uniprot id: F8ADZ0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

667014:THEIN RS02370
gene id: 667014:THEIN_RS02370
uniprot id: F8AAY9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS04435
gene id: 667014:THEIN_RS04435
uniprot id: F8ACW2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS06730
gene id: 667014:THEIN_RS06730
uniprot id: F8A978
names: Similarity
messages: Belongs to the MEMO1 family.

667014:THEIN RS05815
gene id: 667014:THEIN_RS05815
uniprot id: F8A820
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS00190
gene id: 667014:THEIN_RS00190
uniprot id: F8A8B8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

667014:THEIN RS05215
gene id: 667014:THEIN_RS05215
uniprot id: F8A8R5
names: Subcellular Location Annotation
messages: Periplasm

667014:THEIN RS05015
gene id: 667014:THEIN_RS05015
uniprot id: F8ADI3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

667014:THEIN RS10770
gene id: 667014:THEIN_RS10770
uniprot id: F8ADE3
names: Similarity
messages: Belongs to the AOR/FOR family.

667014:THEIN RS09780
gene id: 667014:THEIN_RS09780
uniprot id: F8ACD3
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

667014:THEIN RS01405
gene id: 667014:THEIN_RS01405
uniprot id: F8A9W3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

667014:THEIN RS06775
gene id: 667014:THEIN_RS06775
uniprot id: F8A965
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

667014:THEIN RS00460
gene id: 667014:THEIN_RS00460
uniprot id: F8A8H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

667014:THEIN RS06650
gene id: 667014:THEIN_RS06650
uniprot id: F8A946
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

667014:THEIN RS05025
gene id: 667014:THEIN_RS05025
uniprot id: F8ADI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS04905
gene id: 667014:THEIN_RS04905
uniprot id: F8A8Q4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

667014:THEIN RS03545
gene id: 667014:THEIN_RS03545
uniprot id: F8AC28
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

667014:THEIN RS10660
gene id: 667014:THEIN_RS10660
uniprot id: F8ADC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

667014:THEIN RS11280
gene id: 667014:THEIN_RS11280
uniprot id: F8ADU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

667014:THEIN RS06870
gene id: 667014:THEIN_RS06870
uniprot id: F8A9J2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

667014:THEIN RS01910
gene id: 667014:THEIN_RS01910
uniprot id: F8AAC3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

667014:THEIN RS05670
gene id: 667014:THEIN_RS05670
uniprot id: F8AE16
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

667014:THEIN RS05405
gene id: 667014:THEIN_RS05405
uniprot id: F8ADW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

667014:THEIN RS03910
gene id: 667014:THEIN_RS03910
uniprot id: F8ACF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

667014:THEIN RS05055
gene id: 667014:THEIN_RS05055
uniprot id: F8ADJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

667014:THEIN RS10160
gene id: 667014:THEIN_RS10160
uniprot id: F8ACR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the AccA family.
messages: In the N-terminal section; belongs to the AccD/PCCB family.

667014:THEIN RS01300
gene id: 667014:THEIN_RS01300
uniprot id: F8A9U3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS10300
gene id: 667014:THEIN_RS10300
uniprot id: F8AD01
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

667014:THEIN RS01170
gene id: 667014:THEIN_RS01170
uniprot id: F8A9H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

667014:THEIN RS04350
gene id: 667014:THEIN_RS04350
uniprot id: F8ACU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

667014:THEIN RS04205
gene id: 667014:THEIN_RS04205
uniprot id: F8ACK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

667014:THEIN RS05305
gene id: 667014:THEIN_RS05305
uniprot id: F8ADN0
names: Similarity
messages: Belongs to the universal stress protein A family.

667014:THEIN RS07985
gene id: 667014:THEIN_RS07985
uniprot id: F8AAK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

667014:THEIN RS11045
gene id: 667014:THEIN_RS11045
uniprot id: F8ADQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

667014:THEIN RS11295
gene id: 667014:THEIN_RS11295
uniprot id: F8ADU9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

667014:THEIN RS11845
gene id: 667014:THEIN_RS11845
uniprot id: F8ADC9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

667014:THEIN RS02300
gene id: 667014:THEIN_RS02300
uniprot id: F8A868
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

667014:THEIN RS05250
gene id: 667014:THEIN_RS05250
uniprot id: F8ADM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01425
gene id: 667014:THEIN_RS01425
uniprot id: F8A9W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

667014:THEIN RS07585
gene id: 667014:THEIN_RS07585
uniprot id: F8AA62
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

667014:THEIN RS07475
gene id: 667014:THEIN_RS07475
uniprot id: F8AA42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

667014:THEIN RS01500
gene id: 667014:THEIN_RS01500
uniprot id: F8A9X7
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

667014:THEIN RS05810
gene id: 667014:THEIN_RS05810
uniprot id: F8A819
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05065
gene id: 667014:THEIN_RS05065
uniprot id: F8ADJ3
names: Subcellular Location Annotation
messages: Cytoplasm

667014:THEIN RS02720
gene id: 667014:THEIN_RS02720
uniprot id: F8ABB2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

667014:THEIN RS07850
gene id: 667014:THEIN_RS07850
uniprot id: F8AAI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

667014:THEIN RS00385
gene id: 667014:THEIN_RS00385
uniprot id: F8A8F7
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

667014:THEIN RS03340
gene id: 667014:THEIN_RS03340
uniprot id: F8ABT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS06755
gene id: 667014:THEIN_RS06755
uniprot id: F8A962
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS09715
gene id: 667014:THEIN_RS09715
uniprot id: F8ACC2
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

667014:THEIN RS05085
gene id: 667014:THEIN_RS05085
uniprot id: F8ADJ7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

667014:THEIN RS02275
gene id: 667014:THEIN_RS02275
uniprot id: F8AAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

667014:THEIN RS11210
gene id: 667014:THEIN_RS11210
uniprot id: F8ADT5
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

667014:THEIN RS09200
gene id: 667014:THEIN_RS09200
uniprot id: F8ABX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01675
gene id: 667014:THEIN_RS01675
uniprot id: F8AA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS09515
gene id: 667014:THEIN_RS09515
uniprot id: F8AC87
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

667014:THEIN RS05300
gene id: 667014:THEIN_RS05300
uniprot id: F8ADM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

667014:THEIN RS08015
gene id: 667014:THEIN_RS08015
uniprot id: F8AAS3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

667014:THEIN RS01385
gene id: 667014:THEIN_RS01385
uniprot id: F8A9V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

667014:THEIN RS00660
gene id: 667014:THEIN_RS00660
uniprot id: F8A8W9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

667014:THEIN RS05060
gene id: 667014:THEIN_RS05060
uniprot id: F8ADJ2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

667014:THEIN RS10705
gene id: 667014:THEIN_RS10705
uniprot id: F8ADD0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

667014:THEIN RS07185
gene id: 667014:THEIN_RS07185
uniprot id: F8A990
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

667014:THEIN RS01965
gene id: 667014:THEIN_RS01965
uniprot id: F8AAD2
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

667014:THEIN RS03990
gene id: 667014:THEIN_RS03990
uniprot id: F8ACH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

667014:THEIN RS06285
gene id: 667014:THEIN_RS06285
uniprot id: F8A8T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

667014:THEIN RS05715
gene id: 667014:THEIN_RS05715
uniprot id: F8A802
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS06765
gene id: 667014:THEIN_RS06765
uniprot id: F8A964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

667014:THEIN RS06550
gene id: 667014:THEIN_RS06550
uniprot id: F8A926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

667014:THEIN RS06605
gene id: 667014:THEIN_RS06605
uniprot id: F8A937
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

667014:THEIN RS00570
gene id: 667014:THEIN_RS00570
uniprot id: F8A8V2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

667014:THEIN RS07625
gene id: 667014:THEIN_RS07625
uniprot id: F8AAE0
names: Similarity
messages: Belongs to the UPF0175 family.

667014:THEIN RS06310
gene id: 667014:THEIN_RS06310
uniprot id: F8A8L9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

667014:THEIN RS09580
gene id: 667014:THEIN_RS09580
uniprot id: F8AC99
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

667014:THEIN RS06985
gene id: 667014:THEIN_RS06985
uniprot id: F8A9L4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

667014:THEIN RS06760
gene id: 667014:THEIN_RS06760
uniprot id: F8A963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

667014:THEIN RS07170
gene id: 667014:THEIN_RS07170
uniprot id: F8A9P4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS10450
gene id: 667014:THEIN_RS10450
uniprot id: F8AD26
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

667014:THEIN RS06770
gene id: 667014:THEIN_RS06770
uniprot id: F8A979
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

667014:THEIN RS11415
gene id: 667014:THEIN_RS11415
uniprot id: F8A7X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

667014:THEIN RS09725
gene id: 667014:THEIN_RS09725
uniprot id: F8ACC4
names: Similarity
messages: Belongs to the histone deacetylase family.

667014:THEIN RS08605
gene id: 667014:THEIN_RS08605
uniprot id: F8AB90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

667014:THEIN RS06980
gene id: 667014:THEIN_RS06980
uniprot id: F8A9L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

667014:THEIN RS04365
gene id: 667014:THEIN_RS04365
uniprot id: F8ACU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

667014:THEIN RS06975
gene id: 667014:THEIN_RS06975
uniprot id: F8A9L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS05885
gene id: 667014:THEIN_RS05885
uniprot id: F8A831
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS02850
gene id: 667014:THEIN_RS02850
uniprot id: F8ABD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

667014:THEIN RS04985
gene id: 667014:THEIN_RS04985
uniprot id: F8ADH7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

667014:THEIN RS09765
gene id: 667014:THEIN_RS09765
uniprot id: F8ACD0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

667014:THEIN RS06995
gene id: 667014:THEIN_RS06995
uniprot id: F8A9L6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01625
gene id: 667014:THEIN_RS01625
uniprot id: F8A9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

667014:THEIN RS05010
gene id: 667014:THEIN_RS05010
uniprot id: F8ADI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS07805
gene id: 667014:THEIN_RS07805
uniprot id: F8AAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

667014:THEIN RS05385
gene id: 667014:THEIN_RS05385
uniprot id: F8ADW5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

667014:THEIN RS11630
gene id: 667014:THEIN_RS11630
uniprot id: F8A929
names: Similarity
messages: Belongs to the UPF0111 family.

667014:THEIN RS03200
gene id: 667014:THEIN_RS03200
uniprot id: F8ABR6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

667014:THEIN RS10930
gene id: 667014:THEIN_RS10930
uniprot id: F8ADH2
names: Similarity
messages: Belongs to the GSP E family.

667014:THEIN RS09010
gene id: 667014:THEIN_RS09010
uniprot id: F8ABM4
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05030
gene id: 667014:THEIN_RS05030
uniprot id: F8ADI6
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

667014:THEIN RS04670
gene id: 667014:THEIN_RS04670
uniprot id: F8AD64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01475
gene id: 667014:THEIN_RS01475
uniprot id: F8A9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

667014:THEIN RS09410
gene id: 667014:THEIN_RS09410
uniprot id: F8A9Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS00305
gene id: 667014:THEIN_RS00305
uniprot id: F8A8E1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS04000
gene id: 667014:THEIN_RS04000
uniprot id: F8ACH2
names: Similarity
messages: Belongs to the peptidase U62 family.

667014:THEIN RS08020
gene id: 667014:THEIN_RS08020
uniprot id: F8AAS4
names: Similarity
messages: Belongs to the peptidase S8 family.

667014:THEIN RS08320
gene id: 667014:THEIN_RS08320
uniprot id: F8A9A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

667014:THEIN RS04510
gene id: 667014:THEIN_RS04510
uniprot id: F8ACX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS08355
gene id: 667014:THEIN_RS08355
uniprot id: F8AAY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS10405
gene id: 667014:THEIN_RS10405
uniprot id: F8A9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

667014:THEIN RS05900
gene id: 667014:THEIN_RS05900
uniprot id: F8A834
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

667014:THEIN RS03505
gene id: 667014:THEIN_RS03505
uniprot id: F8AC20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS03405
gene id: 667014:THEIN_RS03405
uniprot id: F8ABU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

667014:THEIN RS01395
gene id: 667014:THEIN_RS01395
uniprot id: F8A9W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

667014:THEIN RS04370
gene id: 667014:THEIN_RS04370
uniprot id: F8ACV0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

667014:THEIN RS02375
gene id: 667014:THEIN_RS02375
uniprot id: F8AAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

667014:THEIN RS06545
gene id: 667014:THEIN_RS06545
uniprot id: F8A925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

667014:THEIN RS06715
gene id: 667014:THEIN_RS06715
uniprot id: F8A956
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

667014:THEIN RS06390
gene id: 667014:THEIN_RS06390
uniprot id: F8A8N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

667014:THEIN RS01770
gene id: 667014:THEIN_RS01770
uniprot id: F8AA96
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

667014:THEIN RS04480
gene id: 667014:THEIN_RS04480
uniprot id: F8ACW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

667014:THEIN RS09030
gene id: 667014:THEIN_RS09030
uniprot id: F8ABM8
names: Subcellular Location Annotation
messages: Cytoplasm

667014:THEIN RS00880
gene id: 667014:THEIN_RS00880
uniprot id: F8A910
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS02170
gene id: 667014:THEIN_RS02170
uniprot id: F8AAP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

667014:THEIN RS03480
gene id: 667014:THEIN_RS03480
uniprot id: F8AC16
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07935
gene id: 667014:THEIN_RS07935
uniprot id: F8AAJ6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

667014:THEIN RS04140
gene id: 667014:THEIN_RS04140
uniprot id: F8ACJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

667014:THEIN RS07410
gene id: 667014:THEIN_RS07410
uniprot id: F8AA31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

667014:THEIN RS10985
gene id: 667014:THEIN_RS10985
uniprot id: F8ADP4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

667014:THEIN RS05370
gene id: 667014:THEIN_RS05370
uniprot id: F8ADW2
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

667014:THEIN RS06435
gene id: 667014:THEIN_RS06435
uniprot id: F8A8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

667014:THEIN RS00155
gene id: 667014:THEIN_RS00155
uniprot id: F8A800
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

667014:THEIN RS09740
gene id: 667014:THEIN_RS09740
uniprot id: F8ACC7
names: Similarity
messages: Belongs to the UPF0758 family.

667014:THEIN RS03870
gene id: 667014:THEIN_RS03870
uniprot id: F8ACE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

667014:THEIN RS05275
gene id: 667014:THEIN_RS05275
uniprot id: F8ADM5
names: Similarity
messages: Belongs to the peptidase U62 family.

667014:THEIN RS03560
gene id: 667014:THEIN_RS03560
uniprot id: F8AC31
names: Similarity
messages: Belongs to the FemABX family.

667014:THEIN RS06485
gene id: 667014:THEIN_RS06485
uniprot id: F8A915
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

667014:THEIN RS03020
gene id: 667014:THEIN_RS03020
uniprot id: F8A882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

667014:THEIN RS03375
gene id: 667014:THEIN_RS03375
uniprot id: F8ABU2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS00450
gene id: 667014:THEIN_RS00450
uniprot id: F8A8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

667014:THEIN RS04425
gene id: 667014:THEIN_RS04425
uniprot id: F8ACW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS03190
gene id: 667014:THEIN_RS03190
uniprot id: F8ABR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

667014:THEIN RS09310
gene id: 667014:THEIN_RS09310
uniprot id: F8A9Q3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

667014:THEIN RS02830
gene id: 667014:THEIN_RS02830
uniprot id: F8ABD4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

667014:THEIN RS04740
gene id: 667014:THEIN_RS04740
uniprot id: F8AD75
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS01510
gene id: 667014:THEIN_RS01510
uniprot id: F8A9X8
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

667014:THEIN RS10675
gene id: 667014:THEIN_RS10675
uniprot id: F8ADC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

667014:THEIN RS03180
gene id: 667014:THEIN_RS03180
uniprot id: F8ABR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

667014:THEIN RS01380
gene id: 667014:THEIN_RS01380
uniprot id: F8A9V8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

667014:THEIN RS04415
gene id: 667014:THEIN_RS04415
uniprot id: F8ACV8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

667014:THEIN RS07490
gene id: 667014:THEIN_RS07490
uniprot id: F8AA45
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

667014:THEIN RS00595
gene id: 667014:THEIN_RS00595
uniprot id: F8A8V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS05720
gene id: 667014:THEIN_RS05720
uniprot id: F8A803
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

667014:THEIN RS03530
gene id: 667014:THEIN_RS03530
uniprot id: F8AC25
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

667014:THEIN RS04535
gene id: 667014:THEIN_RS04535
uniprot id: F8ACX9
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

667014:THEIN RS01145
gene id: 667014:THEIN_RS01145
uniprot id: F8A9G8
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

667014:THEIN RS08645
gene id: 667014:THEIN_RS08645
uniprot id: F8AB96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

667014:THEIN RS08770
gene id: 667014:THEIN_RS08770
uniprot id: F8ABI1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

667014:THEIN RS08545
gene id: 667014:THEIN_RS08545
uniprot id: F8AB79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS06515
gene id: 667014:THEIN_RS06515
uniprot id: F8A920
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

667014:THEIN RS07950
gene id: 667014:THEIN_RS07950
uniprot id: F8AAJ8
names: Similarity
messages: Belongs to the peptidase M18 family.

667014:THEIN RS06345
gene id: 667014:THEIN_RS06345
uniprot id: F8A8M5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

667014:THEIN RS10745
gene id: 667014:THEIN_RS10745
uniprot id: F8ADD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS02450
gene id: 667014:THEIN_RS02450
uniprot id: F8AB05
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

667014:THEIN RS05005
gene id: 667014:THEIN_RS05005
uniprot id: F8ADI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS08200
gene id: 667014:THEIN_RS08200
uniprot id: F8AAV6
names: Similarity
messages: Belongs to the AdoMet synthase family.

667014:THEIN RS00330
gene id: 667014:THEIN_RS00330
uniprot id: F8A8E6
names: Similarity
messages: Belongs to the alkaline phosphatase family.

667014:THEIN RS04120
gene id: 667014:THEIN_RS04120
uniprot id: F8ACJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

667014:THEIN RS03745
gene id: 667014:THEIN_RS03745
uniprot id: F8AC66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

667014:THEIN RS09365
gene id: 667014:THEIN_RS09365
uniprot id: F8ABZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

667014:THEIN RS07250
gene id: 667014:THEIN_RS07250
uniprot id: F8AA05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

667014:THEIN RS00045
gene id: 667014:THEIN_RS00045
uniprot id: F8A7X9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

667014:THEIN RS04420
gene id: 667014:THEIN_RS04420
uniprot id: F8ACV9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

667014:THEIN RS02365
gene id: 667014:THEIN_RS02365
uniprot id: F8AAY8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

667014:THEIN RS03110
gene id: 667014:THEIN_RS03110
uniprot id: F8ABP7
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

667014:THEIN RS07815
gene id: 667014:THEIN_RS07815
uniprot id: F8AAH6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

667014:THEIN RS04520
gene id: 667014:THEIN_RS04520
uniprot id: F8ACX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

667014:THEIN RS05105
gene id: 667014:THEIN_RS05105
uniprot id: F8ADK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

667014:THEIN RS06135
gene id: 667014:THEIN_RS06135
uniprot id: F8A8I7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

667014:THEIN RS01450
gene id: 667014:THEIN_RS01450
uniprot id: F8A9W9
names: Similarity
messages: Belongs to the HdrA family.

667014:THEIN RS01075
gene id: 667014:THEIN_RS01075
uniprot id: F8A9F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

667014:THEIN RS02765
gene id: 667014:THEIN_RS02765
uniprot id: F8ABC1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

667014:THEIN RS03165
gene id: 667014:THEIN_RS03165
uniprot id: F8ABQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

667014:THEIN RS01320
gene id: 667014:THEIN_RS01320
uniprot id: F8A9U7
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

667014:THEIN RS06130
gene id: 667014:THEIN_RS06130
uniprot id: F8A8I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

667014:THEIN RS09535
gene id: 667014:THEIN_RS09535
uniprot id: F8AC91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

667014:THEIN RS08975
gene id: 667014:THEIN_RS08975
uniprot id: F8ABL8
names: Similarity
messages: Belongs to the alkaline phosphatase family.

667014:THEIN RS02685
gene id: 667014:THEIN_RS02685
uniprot id: F8AB45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS05645
gene id: 667014:THEIN_RS05645
uniprot id: F8AE12
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

667014:THEIN RS06205
gene id: 667014:THEIN_RS06205
uniprot id: F8A8K0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

667014:THEIN RS10490
gene id: 667014:THEIN_RS10490
uniprot id: F8AD32
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

667014:THEIN RS02810
gene id: 667014:THEIN_RS02810
uniprot id: F8ABD0
names: Similarity
messages: Belongs to the leucine-binding protein family.

667014:THEIN RS09220
gene id: 667014:THEIN_RS09220
uniprot id: F8ABX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

667014:THEIN RS01950
gene id: 667014:THEIN_RS01950
uniprot id: F8AAD0
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

667014:THEIN RS06725
gene id: 667014:THEIN_RS06725
uniprot id: F8A957
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

667014:THEIN RS00440
gene id: 667014:THEIN_RS00440
uniprot id: F8AE39
names: Similarity
messages: Belongs to the Pal lipoprotein family.

667014:THEIN RS07875
gene id: 667014:THEIN_RS07875
uniprot id: F8AAI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

667014:THEIN RS02805
gene id: 667014:THEIN_RS02805
uniprot id: F8ABC9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

667014:THEIN RS02630
gene id: 667014:THEIN_RS02630
uniprot id: F8AB35
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

667014:THEIN RS07770
gene id: 667014:THEIN_RS07770
uniprot id: F8AAG7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

667014:THEIN RS04450
gene id: 667014:THEIN_RS04450
uniprot id: F8ACW4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

667014:THEIN RS11615
gene id: 667014:THEIN_RS11615
uniprot id: F8A8I4
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07555
gene id: 667014:THEIN_RS07555
uniprot id: F8AA58
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS05280
gene id: 667014:THEIN_RS05280
uniprot id: F8A8R9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

667014:THEIN RS04840
gene id: 667014:THEIN_RS04840
uniprot id: F8AD93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

667014:THEIN RS02870
gene id: 667014:THEIN_RS02870
uniprot id: F8ABE2
names: Similarity
messages: Belongs to the peptidase S66 family.

667014:THEIN RS09810
gene id: 667014:THEIN_RS09810
uniprot id: F8ACD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

667014:THEIN RS10820
gene id: 667014:THEIN_RS10820
uniprot id: F8ADF2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS01005
gene id: 667014:THEIN_RS01005
uniprot id: F8A9E4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

667014:THEIN RS03590
gene id: 667014:THEIN_RS03590
uniprot id: F8AC37
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

667014:THEIN RS08460
gene id: 667014:THEIN_RS08460
uniprot id: F8AB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS11650
gene id: 667014:THEIN_RS11650
uniprot id: F8A949
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

667014:THEIN RS09805
gene id: 667014:THEIN_RS09805
uniprot id: F8A9R4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS04590
gene id: 667014:THEIN_RS04590
uniprot id: F8AD50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

667014:THEIN RS10540
gene id: 667014:THEIN_RS10540
uniprot id: F8AD41
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

667014:THEIN RS01270
gene id: 667014:THEIN_RS01270
uniprot id: F8A9T7
names: Similarity
messages: Belongs to the leucine-binding protein family.

667014:THEIN RS06145
gene id: 667014:THEIN_RS06145
uniprot id: F8A8I9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

667014:THEIN RS10180
gene id: 667014:THEIN_RS10180
uniprot id: F8ACR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

667014:THEIN RS01690
gene id: 667014:THEIN_RS01690
uniprot id: F8AA78
names: Similarity
messages: Belongs to the universal stress protein A family.

667014:THEIN RS04310
gene id: 667014:THEIN_RS04310
uniprot id: F8ACT7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

667014:THEIN RS03145
gene id: 667014:THEIN_RS03145
uniprot id: F8ABQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

667014:THEIN RS02845
gene id: 667014:THEIN_RS02845
uniprot id: F8ABD7
names: Similarity
messages: Belongs to the UPF0166 family.

667014:THEIN RS00925
gene id: 667014:THEIN_RS00925
uniprot id: F8A9C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

667014:THEIN RS00905
gene id: 667014:THEIN_RS00905
uniprot id: F8A9C4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

667014:THEIN RS08280
gene id: 667014:THEIN_RS08280
uniprot id: F8AAX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS10215
gene id: 667014:THEIN_RS10215
uniprot id: F8ACY8
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS03950
gene id: 667014:THEIN_RS03950
uniprot id: F8ACG2
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS07975
gene id: 667014:THEIN_RS07975
uniprot id: F8AAK1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

667014:THEIN RS05940
gene id: 667014:THEIN_RS05940
uniprot id: F8A8S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

667014:THEIN RS08995
gene id: 667014:THEIN_RS08995
uniprot id: F8ABM1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

667014:THEIN RS02065
gene id: 667014:THEIN_RS02065
uniprot id: F8AAM0
names: Similarity
messages: Belongs to the GSP E family.

667014:THEIN RS01595
gene id: 667014:THEIN_RS01595
uniprot id: F8AE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

667014:THEIN RS02670
gene id: 667014:THEIN_RS02670
uniprot id: F8AB42
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

667014:THEIN RS01520
gene id: 667014:THEIN_RS01520
uniprot id: F8A9Y0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

667014:THEIN RS03755
gene id: 667014:THEIN_RS03755
uniprot id: F8AC68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

667014:THEIN RS04145
gene id: 667014:THEIN_RS04145
uniprot id: F8ACJ7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

667014:THEIN RS10145
gene id: 667014:THEIN_RS10145
uniprot id: F8ACQ9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

667014:THEIN RS01390
gene id: 667014:THEIN_RS01390
uniprot id: F8A9W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

667014:THEIN RS02780
gene id: 667014:THEIN_RS02780
uniprot id: F8ABC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

667014:THEIN RS04110
gene id: 667014:THEIN_RS04110
uniprot id: F8A8A8
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

667014:THEIN RS06245
gene id: 667014:THEIN_RS06245
uniprot id: F8A8K8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

667014:THEIN RS08425
gene id: 667014:THEIN_RS08425
uniprot id: F8AB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

667014:THEIN RS03410
gene id: 667014:THEIN_RS03410
uniprot id: F8ABU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

667014:THEIN RS04935
gene id: 667014:THEIN_RS04935
uniprot id: F8ADA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

667014:THEIN RS04250
gene id: 667014:THEIN_RS04250
uniprot id: F8ACS5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS11660
gene id: 667014:THEIN_RS11660
uniprot id: F8A972
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

667014:THEIN RS04280
gene id: 667014:THEIN_RS04280
uniprot id: F8ACT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

667014:THEIN RS00115
gene id: 667014:THEIN_RS00115
uniprot id: F8A7Z3
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS05415
gene id: 667014:THEIN_RS05415
uniprot id: F8ADX1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

667014:THEIN RS05020
gene id: 667014:THEIN_RS05020
uniprot id: F8ADI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

667014:THEIN RS03115
gene id: 667014:THEIN_RS03115
uniprot id: F8ABP8
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

667014:THEIN RS03050
gene id: 667014:THEIN_RS03050
uniprot id: F8ABH1
names: Subcellular Location Annotation
messages: Membrane

667014:THEIN RS08715
gene id: 667014:THEIN_RS08715
uniprot id: F8ABA5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

667014:THEIN RS08145
gene id: 667014:THEIN_RS08145
uniprot id: F8AAU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

667014:THEIN RS05525
gene id: 667014:THEIN_RS05525
uniprot id: F8ADZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

667014:THEIN RS08785
gene id: 667014:THEIN_RS08785
uniprot id: F8ABI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

667014:THEIN RS00790
gene id: 667014:THEIN_RS00790
uniprot id: F8A8Z3
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

667014:THEIN RS08295
gene id: 667014:THEIN_RS08295
uniprot id: F8AAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

667014:THEIN RS02295
gene id: 667014:THEIN_RS02295
uniprot id: F8AAR0
names: Similarity
messages: Belongs to the bacterial flagellin family.

667014:THEIN RS06175
gene id: 667014:THEIN_RS06175
uniprot id: F8A8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm