651182:TOL2 RS11650
gene id: 651182:TOL2_RS11650
uniprot id: K0NGH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

651182:TOL2 RS09855
gene id: 651182:TOL2_RS09855
uniprot id: K0NMS8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS16150
gene id: 651182:TOL2_RS16150
uniprot id: K0NQH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

651182:TOL2 RS01195
gene id: 651182:TOL2_RS01195
uniprot id: K0NC56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS17790
gene id: 651182:TOL2_RS17790
uniprot id: K0NRD9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS03065
gene id: 651182:TOL2_RS03065
uniprot id: K0NG19
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

651182:TOL2 RS00295
gene id: 651182:TOL2_RS00295
uniprot id: K0NC72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS09890
gene id: 651182:TOL2_RS09890
uniprot id: K0NJG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS22690
gene id: 651182:TOL2_RS22690
uniprot id: K0NP29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

651182:TOL2 RS07300
gene id: 651182:TOL2_RS07300
uniprot id: K0NLF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

651182:TOL2 RS02610
gene id: 651182:TOL2_RS02610
uniprot id: K0NCR3
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18515
gene id: 651182:TOL2_RS18515
uniprot id: K0NRQ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

651182:TOL2 RS18250
gene id: 651182:TOL2_RS18250
uniprot id: K0NBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS18935
gene id: 651182:TOL2_RS18935
uniprot id: K0NJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

651182:TOL2 RS01250
gene id: 651182:TOL2_RS01250
uniprot id: K0NCI9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS15260
gene id: 651182:TOL2_RS15260
uniprot id: K0NAE8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS09895
gene id: 651182:TOL2_RS09895
uniprot id: K0N7V2
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

651182:TOL2 RS09720
gene id: 651182:TOL2_RS09720
uniprot id: K0NFR1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS03950
gene id: 651182:TOL2_RS03950
uniprot id: K0NIT7
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

651182:TOL2 RS02590
gene id: 651182:TOL2_RS02590
uniprot id: K0NI39
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS11815
gene id: 651182:TOL2_RS11815
uniprot id: K0NKA2
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

651182:TOL2 RS14700
gene id: 651182:TOL2_RS14700
uniprot id: K0NA17
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS18030
gene id: 651182:TOL2_RS18030
uniprot id: K0NBA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

651182:TOL2 RS17285
gene id: 651182:TOL2_RS17285
uniprot id: K0NMZ9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS01735
gene id: 651182:TOL2_RS01735
uniprot id: K0NFK0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

651182:TOL2 RS02195
gene id: 651182:TOL2_RS02195
uniprot id: K0N386
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

651182:TOL2 RS15595
gene id: 651182:TOL2_RS15595
uniprot id: K0NJQ9
names: Similarity
messages: Belongs to the peptidase M16 family.

651182:TOL2 RS08410
gene id: 651182:TOL2_RS08410
uniprot id: K0NFL9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

651182:TOL2 RS22025
gene id: 651182:TOL2_RS22025
uniprot id: K0NQ67
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS22410
gene id: 651182:TOL2_RS22410
uniprot id: K0NTJ5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS10235
gene id: 651182:TOL2_RS10235
uniprot id: K0NG15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

651182:TOL2 RS22830
gene id: 651182:TOL2_RS22830
uniprot id: K0NTQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

651182:TOL2 RS02555
gene id: 651182:TOL2_RS02555
uniprot id: K0ND18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

651182:TOL2 RS06520
gene id: 651182:TOL2_RS06520
uniprot id: K0NKV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

651182:TOL2 RS14695
gene id: 651182:TOL2_RS14695
uniprot id: K0NLG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS12800
gene id: 651182:TOL2_RS12800
uniprot id: K0N9G0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS01170
gene id: 651182:TOL2_RS01170
uniprot id: K0NC52
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS00900
gene id: 651182:TOL2_RS00900
uniprot id: K0NH40
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05640
gene id: 651182:TOL2_RS05640
uniprot id: K0NH60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

651182:TOL2 RS20670
gene id: 651182:TOL2_RS20670
uniprot id: K0NPK1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS21120
gene id: 651182:TOL2_RS21120
uniprot id: K0NCE1
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

651182:TOL2 RS18970
gene id: 651182:TOL2_RS18970
uniprot id: K0NNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

651182:TOL2 RS00620
gene id: 651182:TOL2_RS00620
uniprot id: K0NGZ6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

651182:TOL2 RS19895
gene id: 651182:TOL2_RS19895
uniprot id: K0NK37
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

651182:TOL2 RS18570
gene id: 651182:TOL2_RS18570
uniprot id: K0NNN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

651182:TOL2 RS07080
gene id: 651182:TOL2_RS07080
uniprot id: K0NLA2
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

651182:TOL2 RS18480
gene id: 651182:TOL2_RS18480
uniprot id: K0NBE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

651182:TOL2 RS20630
gene id: 651182:TOL2_RS20630
uniprot id: K0NN67
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS11660
gene id: 651182:TOL2_RS11660
uniprot id: K0NK83
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS02730
gene id: 651182:TOL2_RS02730
uniprot id: K0ND34
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS14485
gene id: 651182:TOL2_RS14485
uniprot id: K0NLH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS17525
gene id: 651182:TOL2_RS17525
uniprot id: K0NKY5
names: Function
names: Similarity
messages: Belongs to the DtxR/MntR family.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.

651182:TOL2 RS10655
gene id: 651182:TOL2_RS10655
uniprot id: K0NJT4
names: Similarity
messages: Belongs to the TlyA family.

651182:TOL2 RS02045
gene id: 651182:TOL2_RS02045
uniprot id: K0N366
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

651182:TOL2 RS20795
gene id: 651182:TOL2_RS20795
uniprot id: K0NSV3
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

651182:TOL2 RS10090
gene id: 651182:TOL2_RS10090
uniprot id: K0NGK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

651182:TOL2 RS10065
gene id: 651182:TOL2_RS10065
uniprot id: K0NGK3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

651182:TOL2 RS01700
gene id: 651182:TOL2_RS01700
uniprot id: K0NHM1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS07570
gene id: 651182:TOL2_RS07570
uniprot id: K0NFB0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

651182:TOL2 RS18540
gene id: 651182:TOL2_RS18540
uniprot id: K0NRQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

651182:TOL2 RS16800
gene id: 651182:TOL2_RS16800
uniprot id: K0NKD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

651182:TOL2 RS13405
gene id: 651182:TOL2_RS13405
uniprot id: K0NL37
names: Similarity
messages: Belongs to the SlyX family.

651182:TOL2 RS10460
gene id: 651182:TOL2_RS10460
uniprot id: K0NGP7
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS01940
gene id: 651182:TOL2_RS01940
uniprot id: K0N335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

651182:TOL2 RS00345
gene id: 651182:TOL2_RS00345
uniprot id: K0NBY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

651182:TOL2 RS20800
gene id: 651182:TOL2_RS20800
uniprot id: K0NPL9
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

651182:TOL2 RS21905
gene id: 651182:TOL2_RS21905
uniprot id: K0NCM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

651182:TOL2 RS05795
gene id: 651182:TOL2_RS05795
uniprot id: K0NKB5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

651182:TOL2 RS18625
gene id: 651182:TOL2_RS18625
uniprot id: K0NRS2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

651182:TOL2 RS22155
gene id: 651182:TOL2_RS22155
uniprot id: K0NNU2
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS05330
gene id: 651182:TOL2_RS05330
uniprot id: K0NE81
names: Similarity
messages: Belongs to the band 7/mec-2 family.

651182:TOL2 RS11340
gene id: 651182:TOL2_RS11340
uniprot id: K0NNE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

651182:TOL2 RS10295
gene id: 651182:TOL2_RS10295
uniprot id: K0NJN3
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS14160
gene id: 651182:TOL2_RS14160
uniprot id: K0NLC1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS13435
gene id: 651182:TOL2_RS13435
uniprot id: K0NPC0
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

651182:TOL2 RS08095
gene id: 651182:TOL2_RS08095
uniprot id: K0NEX0
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS15580
gene id: 651182:TOL2_RS15580
uniprot id: K0NQB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

651182:TOL2 RS08770
gene id: 651182:TOL2_RS08770
uniprot id: K0N745
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

651182:TOL2 RS14860
gene id: 651182:TOL2_RS14860
uniprot id: K0NHQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS23155
gene id: 651182:TOL2_RS23155
uniprot id: K0NTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

651182:TOL2 RS17820
gene id: 651182:TOL2_RS17820
uniprot id: K0NNA5
names: Similarity
messages: Belongs to the CmpA/NrtA family.

651182:TOL2 RS00915
gene id: 651182:TOL2_RS00915
uniprot id: K0NCE8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS13195
gene id: 651182:TOL2_RS13195
uniprot id: K0NP94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

651182:TOL2 RS02570
gene id: 651182:TOL2_RS02570
uniprot id: K0NFW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

651182:TOL2 RS19560
gene id: 651182:TOL2_RS19560
uniprot id: K0NS69
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS00835
gene id: 651182:TOL2_RS00835
uniprot id: K0N2E7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS22010
gene id: 651182:TOL2_RS22010
uniprot id: K0NNR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS04135
gene id: 651182:TOL2_RS04135
uniprot id: K0N489
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS15560
gene id: 651182:TOL2_RS15560
uniprot id: K0NM28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

651182:TOL2 RS02520
gene id: 651182:TOL2_RS02520
uniprot id: K0N3D0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

651182:TOL2 RS17625
gene id: 651182:TOL2_RS17625
uniprot id: K0NL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS09495
gene id: 651182:TOL2_RS09495
uniprot id: K0N7K5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

651182:TOL2 RS09805
gene id: 651182:TOL2_RS09805
uniprot id: K0NMR7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

651182:TOL2 RS22700
gene id: 651182:TOL2_RS22700
uniprot id: K0NTN4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

651182:TOL2 RS05870
gene id: 651182:TOL2_RS05870
uniprot id: K0NKD8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS11015
gene id: 651182:TOL2_RS11015
uniprot id: K0NPI6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS21755
gene id: 651182:TOL2_RS21755
uniprot id: K0NQ16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

651182:TOL2 RS09330
gene id: 651182:TOL2_RS09330
uniprot id: K0N7G7
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

651182:TOL2 RS12505
gene id: 651182:TOL2_RS12505
uniprot id: K0NGX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS19200
gene id: 651182:TOL2_RS19200
uniprot id: K0NBN3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

651182:TOL2 RS07475
gene id: 651182:TOL2_RS07475
uniprot id: K0NLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

651182:TOL2 RS01880
gene id: 651182:TOL2_RS01880
uniprot id: K0NHQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

651182:TOL2 RS03140
gene id: 651182:TOL2_RS03140
uniprot id: K0NG34
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

651182:TOL2 RS07450
gene id: 651182:TOL2_RS07450
uniprot id: K0NLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS09530
gene id: 651182:TOL2_RS09530
uniprot id: K0NML3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS18760
gene id: 651182:TOL2_RS18760
uniprot id: K0NRT6
names: Function
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

651182:TOL2 RS07530
gene id: 651182:TOL2_RS07530
uniprot id: K0NLP5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS08575
gene id: 651182:TOL2_RS08575
uniprot id: K0NF52
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

651182:TOL2 RS15140
gene id: 651182:TOL2_RS15140
uniprot id: K0NJD8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

651182:TOL2 RS11420
gene id: 651182:TOL2_RS11420
uniprot id: K0NK52
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

651182:TOL2 RS08795
gene id: 651182:TOL2_RS08795
uniprot id: K0N755
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

651182:TOL2 RS00385
gene id: 651182:TOL2_RS00385
uniprot id: K0N247
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

651182:TOL2 RS16805
gene id: 651182:TOL2_RS16805
uniprot id: K0NIP9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

651182:TOL2 RS07270
gene id: 651182:TOL2_RS07270
uniprot id: K0NEL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

651182:TOL2 RS00375
gene id: 651182:TOL2_RS00375
uniprot id: K0NGV8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

651182:TOL2 RS15355
gene id: 651182:TOL2_RS15355
uniprot id: K0NLY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

651182:TOL2 RS04380
gene id: 651182:TOL2_RS04380
uniprot id: K0NGL1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

651182:TOL2 RS19600
gene id: 651182:TOL2_RS19600
uniprot id: K0NMC5
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS08570
gene id: 651182:TOL2_RS08570
uniprot id: K0NFP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS19375
gene id: 651182:TOL2_RS19375
uniprot id: K0NNX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

651182:TOL2 RS03920
gene id: 651182:TOL2_RS03920
uniprot id: K0NDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

651182:TOL2 RS09285
gene id: 651182:TOL2_RS09285
uniprot id: K0NG31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

651182:TOL2 RS16035
gene id: 651182:TOL2_RS16035
uniprot id: K0NIE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

651182:TOL2 RS01705
gene id: 651182:TOL2_RS01705
uniprot id: K0NFJ5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS17205
gene id: 651182:TOL2_RS17205
uniprot id: K0NR14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

651182:TOL2 RS20510
gene id: 651182:TOL2_RS20510
uniprot id: K0NKD0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

651182:TOL2 RS01370
gene id: 651182:TOL2_RS01370
uniprot id: K0NHF2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS20375
gene id: 651182:TOL2_RS20375
uniprot id: K0NMX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS10335
gene id: 651182:TOL2_RS10335
uniprot id: K0NGM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

651182:TOL2 RS08005
gene id: 651182:TOL2_RS08005
uniprot id: K0NFF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

651182:TOL2 RS01910
gene id: 651182:TOL2_RS01910
uniprot id: K0NFN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

651182:TOL2 RS17105
gene id: 651182:TOL2_RS17105
uniprot id: K0NMW9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS11890
gene id: 651182:TOL2_RS11890
uniprot id: K0NNM9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

651182:TOL2 RS05385
gene id: 651182:TOL2_RS05385
uniprot id: K0NE88
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Belongs to the GARS family.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

651182:TOL2 RS04910
gene id: 651182:TOL2_RS04910
uniprot id: K0NE43
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS02615
gene id: 651182:TOL2_RS02615
uniprot id: K0NI47
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

651182:TOL2 RS21130
gene id: 651182:TOL2_RS21130
uniprot id: K0NKP6
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS22460
gene id: 651182:TOL2_RS22460
uniprot id: K0NTK1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

651182:TOL2 RS08590
gene id: 651182:TOL2_RS08590
uniprot id: K0N6Z6
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

651182:TOL2 RS10750
gene id: 651182:TOL2_RS10750
uniprot id: K0NN70
names: Similarity
messages: Belongs to the Skp family.

651182:TOL2 RS12940
gene id: 651182:TOL2_RS12940
uniprot id: K0NH67
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS00380
gene id: 651182:TOL2_RS00380
uniprot id: K0NF19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

651182:TOL2 RS07750
gene id: 651182:TOL2_RS07750
uniprot id: K0NFC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

651182:TOL2 RS02050
gene id: 651182:TOL2_RS02050
uniprot id: K0NCW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

651182:TOL2 RS05865
gene id: 651182:TOL2_RS05865
uniprot id: K0NE37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

651182:TOL2 RS01495
gene id: 651182:TOL2_RS01495
uniprot id: K0NHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

651182:TOL2 RS02215
gene id: 651182:TOL2_RS02215
uniprot id: K0NHY5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS14395
gene id: 651182:TOL2_RS14395
uniprot id: K0NLG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS03085
gene id: 651182:TOL2_RS03085
uniprot id: K0NIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

651182:TOL2 RS06745
gene id: 651182:TOL2_RS06745
uniprot id: K0NHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

651182:TOL2 RS23435
gene id: 651182:TOL2_RS23435
uniprot id: K0N4P2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS06110
gene id: 651182:TOL2_RS06110
uniprot id: K0N581
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

651182:TOL2 RS22140
gene id: 651182:TOL2_RS22140
uniprot id: K0NTE8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

651182:TOL2 RS19030
gene id: 651182:TOL2_RS19030
uniprot id: K0NLX0
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

651182:TOL2 RS02300
gene id: 651182:TOL2_RS02300
uniprot id: K0NHZ3
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

651182:TOL2 RS16655
gene id: 651182:TOL2_RS16655
uniprot id: K0NQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS12310
gene id: 651182:TOL2_RS12310
uniprot id: K0NKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

651182:TOL2 RS19650
gene id: 651182:TOL2_RS19650
uniprot id: K0NK08
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

651182:TOL2 RS08930
gene id: 651182:TOL2_RS08930
uniprot id: K0NFV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

651182:TOL2 RS13065
gene id: 651182:TOL2_RS13065
uniprot id: K0NKZ3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

651182:TOL2 RS03075
gene id: 651182:TOL2_RS03075
uniprot id: K0ND73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

651182:TOL2 RS05985
gene id: 651182:TOL2_RS05985
uniprot id: K0NEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

651182:TOL2 RS06605
gene id: 651182:TOL2_RS06605
uniprot id: K0N5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

651182:TOL2 RS21020
gene id: 651182:TOL2_RS21020
uniprot id: K0NSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS14510
gene id: 651182:TOL2_RS14510
uniprot id: K0NHR3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS10345
gene id: 651182:TOL2_RS10345
uniprot id: K0NN26
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05810
gene id: 651182:TOL2_RS05810
uniprot id: K0NEC4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

651182:TOL2 RS21900
gene id: 651182:TOL2_RS21900
uniprot id: K0NQ41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

651182:TOL2 RS21610
gene id: 651182:TOL2_RS21610
uniprot id: K0NNI6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS06275
gene id: 651182:TOL2_RS06275
uniprot id: K0NE93
names: Similarity
messages: Belongs to the HdrA family.

651182:TOL2 RS07275
gene id: 651182:TOL2_RS07275
uniprot id: K0NLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

651182:TOL2 RS07045
gene id: 651182:TOL2_RS07045
uniprot id: K0NEV6
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

651182:TOL2 RS06535
gene id: 651182:TOL2_RS06535
uniprot id: K0NEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

651182:TOL2 RS18965
gene id: 651182:TOL2_RS18965
uniprot id: K0NRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

651182:TOL2 RS03035
gene id: 651182:TOL2_RS03035
uniprot id: K0NIB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

651182:TOL2 RS10715
gene id: 651182:TOL2_RS10715
uniprot id: K0NGS6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS08470
gene id: 651182:TOL2_RS08470
uniprot id: K0NFM6
names: Similarity
messages: Belongs to the glutamine synthetase family.

651182:TOL2 RS15565
gene id: 651182:TOL2_RS15565
uniprot id: K0NAJ9
names: Similarity
messages: Belongs to the peptidase S41A family.

651182:TOL2 RS00635
gene id: 651182:TOL2_RS00635
uniprot id: K0NCA7
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

651182:TOL2 RS03235
gene id: 651182:TOL2_RS03235
uniprot id: K0NCZ4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

651182:TOL2 RS19040
gene id: 651182:TOL2_RS19040
uniprot id: K0NRY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

651182:TOL2 RS08230
gene id: 651182:TOL2_RS08230
uniprot id: K0NLY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

651182:TOL2 RS07970
gene id: 651182:TOL2_RS07970
uniprot id: K0NIM0
names: Similarity
messages: Belongs to the RecJ family.

651182:TOL2 RS16040
gene id: 651182:TOL2_RS16040
uniprot id: K0NQG3
names: Similarity
messages: Belongs to the ClpA/ClpB family.

651182:TOL2 RS07320
gene id: 651182:TOL2_RS07320
uniprot id: K0NEM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

651182:TOL2 RS21190
gene id: 651182:TOL2_RS21190
uniprot id: K0NPS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

651182:TOL2 RS09280
gene id: 651182:TOL2_RS09280
uniprot id: K0N7F6
names: Similarity
messages: Belongs to the citrate synthase family.

651182:TOL2 RS10285
gene id: 651182:TOL2_RS10285
uniprot id: K0NG21
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS14560
gene id: 651182:TOL2_RS14560
uniprot id: K0NHQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS18685
gene id: 651182:TOL2_RS18685
uniprot id: K0NBG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS15365
gene id: 651182:TOL2_RS15365
uniprot id: K0NJJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

651182:TOL2 RS16830
gene id: 651182:TOL2_RS16830
uniprot id: K0NIQ5
names: Similarity
messages: Belongs to the DapB family.

651182:TOL2 RS04185
gene id: 651182:TOL2_RS04185
uniprot id: K0N499
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

651182:TOL2 RS12620
gene id: 651182:TOL2_RS12620
uniprot id: K0NKP7
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

651182:TOL2 RS18080
gene id: 651182:TOL2_RS18080
uniprot id: K0NBA9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

651182:TOL2 RS16020
gene id: 651182:TOL2_RS16020
uniprot id: K0NMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

651182:TOL2 RS03280
gene id: 651182:TOL2_RS03280
uniprot id: K0NDA3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS07250
gene id: 651182:TOL2_RS07250
uniprot id: K0NI68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

651182:TOL2 RS16695
gene id: 651182:TOL2_RS16695
uniprot id: K0NKA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

651182:TOL2 RS01185
gene id: 651182:TOL2_RS01185
uniprot id: K0N2K8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS20675
gene id: 651182:TOL2_RS20675
uniprot id: K0NC96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

651182:TOL2 RS19020
gene id: 651182:TOL2_RS19020
uniprot id: K0NNT5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

651182:TOL2 RS06390
gene id: 651182:TOL2_RS06390
uniprot id: K0NKT5
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

651182:TOL2 RS17095
gene id: 651182:TOL2_RS17095
uniprot id: K0NIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS09160
gene id: 651182:TOL2_RS09160
uniprot id: K0NFZ0
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

651182:TOL2 RS17980
gene id: 651182:TOL2_RS17980
uniprot id: K0NLA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS08820
gene id: 651182:TOL2_RS08820
uniprot id: K0N760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

651182:TOL2 RS06565
gene id: 651182:TOL2_RS06565
uniprot id: K0NEC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

651182:TOL2 RS19280
gene id: 651182:TOL2_RS19280
uniprot id: K0NBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

651182:TOL2 RS19240
gene id: 651182:TOL2_RS19240
uniprot id: K0NS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS19250
gene id: 651182:TOL2_RS19250
uniprot id: K0NBN9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS22420
gene id: 651182:TOL2_RS22420
uniprot id: K0NCU3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS03310
gene id: 651182:TOL2_RS03310
uniprot id: K0ND08
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

651182:TOL2 RS18425
gene id: 651182:TOL2_RS18425
uniprot id: K0NNL9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

651182:TOL2 RS17460
gene id: 651182:TOL2_RS17460
uniprot id: K0NR72
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

651182:TOL2 RS09710
gene id: 651182:TOL2_RS09710
uniprot id: K0N7R0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

651182:TOL2 RS06610
gene id: 651182:TOL2_RS06610
uniprot id: K0NEN7
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS01790
gene id: 651182:TOL2_RS01790
uniprot id: K0N2Z7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

651182:TOL2 RS01825
gene id: 651182:TOL2_RS01825
uniprot id: K0NCF0
names: Cofactor
messages: Binds 1 FAD per subunit.

651182:TOL2 RS18545
gene id: 651182:TOL2_RS18545
uniprot id: K0NNN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

651182:TOL2 RS06560
gene id: 651182:TOL2_RS06560
uniprot id: K0NEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

651182:TOL2 RS03285
gene id: 651182:TOL2_RS03285
uniprot id: K0ND03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

651182:TOL2 RS12070
gene id: 651182:TOL2_RS12070
uniprot id: K0NNR5
names: Similarity
messages: Belongs to the CinA family.

651182:TOL2 RS17510
gene id: 651182:TOL2_RS17510
uniprot id: K0NR84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

651182:TOL2 RS09250
gene id: 651182:TOL2_RS09250
uniprot id: K0NJ40
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

651182:TOL2 RS08225
gene id: 651182:TOL2_RS08225
uniprot id: K0NEY1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS23635
gene id: 651182:TOL2_RS23635
uniprot id: K0NNH2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS10565
gene id: 651182:TOL2_RS10565
uniprot id: K0NGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

651182:TOL2 RS20885
gene id: 651182:TOL2_RS20885
uniprot id: K0NNA1
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

651182:TOL2 RS02220
gene id: 651182:TOL2_RS02220
uniprot id: K0NFS8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS04575
gene id: 651182:TOL2_RS04575
uniprot id: K0NGN6
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

651182:TOL2 RS06040
gene id: 651182:TOL2_RS06040
uniprot id: K0NE64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

651182:TOL2 RS01870
gene id: 651182:TOL2_RS01870
uniprot id: K0NCT9
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

651182:TOL2 RS01365
gene id: 651182:TOL2_RS01365
uniprot id: K0NC77
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS12350
gene id: 651182:TOL2_RS12350
uniprot id: K0NGT9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS12305
gene id: 651182:TOL2_RS12305
uniprot id: K0NNW0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

651182:TOL2 RS12550
gene id: 651182:TOL2_RS12550
uniprot id: K0NHU2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

651182:TOL2 RS17945
gene id: 651182:TOL2_RS17945
uniprot id: K0NND0
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

651182:TOL2 RS22705
gene id: 651182:TOL2_RS22705
uniprot id: K0NQK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

651182:TOL2 RS07335
gene id: 651182:TOL2_RS07335
uniprot id: K0N688
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

651182:TOL2 RS05575
gene id: 651182:TOL2_RS05575
uniprot id: K0NK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS03830
gene id: 651182:TOL2_RS03830
uniprot id: K0NGC8
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS19950
gene id: 651182:TOL2_RS19950
uniprot id: K0NK46
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

651182:TOL2 RS00095
gene id: 651182:TOL2_RS00095
uniprot id: K0NBW7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

651182:TOL2 RS13445
gene id: 651182:TOL2_RS13445
uniprot id: K0N9N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

651182:TOL2 RS17965
gene id: 651182:TOL2_RS17965
uniprot id: K0NRG4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

651182:TOL2 RS06755
gene id: 651182:TOL2_RS06755
uniprot id: K0NEQ7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

651182:TOL2 RS08220
gene id: 651182:TOL2_RS08220
uniprot id: K0NFI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS10270
gene id: 651182:TOL2_RS10270
uniprot id: K0NJN0
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS18065
gene id: 651182:TOL2_RS18065
uniprot id: K0NJB7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

651182:TOL2 RS08015
gene id: 651182:TOL2_RS08015
uniprot id: K0NLV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

651182:TOL2 RS12415
gene id: 651182:TOL2_RS12415
uniprot id: K0NKK5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

651182:TOL2 RS00290
gene id: 651182:TOL2_RS00290
uniprot id: K0N229
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

651182:TOL2 RS00885
gene id: 651182:TOL2_RS00885
uniprot id: K0N2F8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS19105
gene id: 651182:TOL2_RS19105
uniprot id: K0NLY5
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS06350
gene id: 651182:TOL2_RS06350
uniprot id: K0N5K5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

651182:TOL2 RS14800
gene id: 651182:TOL2_RS14800
uniprot id: K0NA17
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS19255
gene id: 651182:TOL2_RS19255
uniprot id: K0NM06
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

651182:TOL2 RS05815
gene id: 651182:TOL2_RS05815
uniprot id: K0NE31
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

651182:TOL2 RS23145
gene id: 651182:TOL2_RS23145
uniprot id: K0NPB1
names: Similarity
messages: Belongs to the peptidase M16 family.

651182:TOL2 RS06195
gene id: 651182:TOL2_RS06195
uniprot id: K0NEH6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

651182:TOL2 RS08775
gene id: 651182:TOL2_RS08775
uniprot id: K0NFS0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

651182:TOL2 RS19100
gene id: 651182:TOL2_RS19100
uniprot id: K0NBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS09505
gene id: 651182:TOL2_RS09505
uniprot id: K0NFM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS03010
gene id: 651182:TOL2_RS03010
uniprot id: K0NIB2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

651182:TOL2 RS21955
gene id: 651182:TOL2_RS21955
uniprot id: K0NCN0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

651182:TOL2 RS20410
gene id: 651182:TOL2_RS20410
uniprot id: K0NKA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

651182:TOL2 RS22910
gene id: 651182:TOL2_RS22910
uniprot id: K0NTS2
names: Similarity
messages: Belongs to the AAA ATPase family.

651182:TOL2 RS17805
gene id: 651182:TOL2_RS17805
uniprot id: K0NL56
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

651182:TOL2 RS11310
gene id: 651182:TOL2_RS11310
uniprot id: K0NGC7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

651182:TOL2 RS05950
gene id: 651182:TOL2_RS05950
uniprot id: K0NHC0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS22115
gene id: 651182:TOL2_RS22115
uniprot id: K0NTE3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS07170
gene id: 651182:TOL2_RS07170
uniprot id: K0N646
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS12265
gene id: 651182:TOL2_RS12265
uniprot id: K0NKH6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

651182:TOL2 RS11585
gene id: 651182:TOL2_RS11585
uniprot id: K0NK74
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

651182:TOL2 RS05775
gene id: 651182:TOL2_RS05775
uniprot id: K0NH94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Heterodimer of a large and a small subunit.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

651182:TOL2 RS08235
gene id: 651182:TOL2_RS08235
uniprot id: K0NIQ6
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS09925
gene id: 651182:TOL2_RS09925
uniprot id: K0NGH6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

651182:TOL2 RS21140
gene id: 651182:TOL2_RS21140
uniprot id: K0NPR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS13520
gene id: 651182:TOL2_RS13520
uniprot id: K0N9P2
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

651182:TOL2 RS07195
gene id: 651182:TOL2_RS07195
uniprot id: K0NI52
names: Subunit
messages: Homodimer.

651182:TOL2 RS22085
gene id: 651182:TOL2_RS22085
uniprot id: K0NNS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS01725
gene id: 651182:TOL2_RS01725
uniprot id: K0NCD0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS00150
gene id: 651182:TOL2_RS00150
uniprot id: K0NEZ9
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

651182:TOL2 RS10420
gene id: 651182:TOL2_RS10420
uniprot id: K0NN39
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS14650
gene id: 651182:TOL2_RS14650
uniprot id: K0NHQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS21800
gene id: 651182:TOL2_RS21800
uniprot id: K0NQ23
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS11295
gene id: 651182:TOL2_RS11295
uniprot id: K0NK30
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

651182:TOL2 RS12635
gene id: 651182:TOL2_RS12635
uniprot id: K0NH07
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

651182:TOL2 RS13125
gene id: 651182:TOL2_RS13125
uniprot id: K0NI44
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

651182:TOL2 RS09025
gene id: 651182:TOL2_RS09025
uniprot id: K0N7A5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS09510
gene id: 651182:TOL2_RS09510
uniprot id: K0NMK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS15385
gene id: 651182:TOL2_RS15385
uniprot id: K0NAG6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

651182:TOL2 RS12530
gene id: 651182:TOL2_RS12530
uniprot id: K0NGX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

651182:TOL2 RS15090
gene id: 651182:TOL2_RS15090
uniprot id: K0NJC1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS14500
gene id: 651182:TOL2_RS14500
uniprot id: K0NA17
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS08210
gene id: 651182:TOL2_RS08210
uniprot id: K0NIQ2
names: Similarity
messages: Belongs to the SCO1/2 family.

651182:TOL2 RS19205
gene id: 651182:TOL2_RS19205
uniprot id: K0NM01
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18530
gene id: 651182:TOL2_RS18530
uniprot id: K0NLL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

651182:TOL2 RS05860
gene id: 651182:TOL2_RS05860
uniprot id: K0NED1
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

651182:TOL2 RS06215
gene id: 651182:TOL2_RS06215
uniprot id: K0N5B8
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

651182:TOL2 RS11640
gene id: 651182:TOL2_RS11640
uniprot id: K0N8S3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

651182:TOL2 RS10210
gene id: 651182:TOL2_RS10210
uniprot id: K0NG13
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

651182:TOL2 RS09150
gene id: 651182:TOL2_RS09150
uniprot id: K0NJ19
names: Similarity
messages: Belongs to the UPF0270 family.

651182:TOL2 RS02855
gene id: 651182:TOL2_RS02855
uniprot id: K0N3J3
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18465
gene id: 651182:TOL2_RS18465
uniprot id: K0NJH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

651182:TOL2 RS10135
gene id: 651182:TOL2_RS10135
uniprot id: K0NJL1
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS19170
gene id: 651182:TOL2_RS19170
uniprot id: K0NNV2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

651182:TOL2 RS04650
gene id: 651182:TOL2_RS04650
uniprot id: K0NDR3
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

651182:TOL2 RS18610
gene id: 651182:TOL2_RS18610
uniprot id: K0NLM4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

651182:TOL2 RS11095
gene id: 651182:TOL2_RS11095
uniprot id: K0NNA9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS01600
gene id: 651182:TOL2_RS01600
uniprot id: K0NCB2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05525
gene id: 651182:TOL2_RS05525
uniprot id: K0NH43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

651182:TOL2 RS15550
gene id: 651182:TOL2_RS15550
uniprot id: K0NI82
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

651182:TOL2 RS02890
gene id: 651182:TOL2_RS02890
uniprot id: K0ND54
names: Similarity
messages: Belongs to the UPF0047 family.

651182:TOL2 RS12545
gene id: 651182:TOL2_RS12545
uniprot id: K0N980
names: Similarity
messages: Belongs to the peptidase M1 family.

651182:TOL2 RS19050
gene id: 651182:TOL2_RS19050
uniprot id: K0NBL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

651182:TOL2 RS01755
gene id: 651182:TOL2_RS01755
uniprot id: K0NHN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS18520
gene id: 651182:TOL2_RS18520
uniprot id: K0NNN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

651182:TOL2 RS12285
gene id: 651182:TOL2_RS12285
uniprot id: K0NNV4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

651182:TOL2 RS13130
gene id: 651182:TOL2_RS13130
uniprot id: K0NH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

651182:TOL2 RS18090
gene id: 651182:TOL2_RS18090
uniprot id: K0NJC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS14170
gene id: 651182:TOL2_RS14170
uniprot id: K0NIP4
names: Similarity
messages: Belongs to the DEAD box helicase family.

651182:TOL2 RS21570
gene id: 651182:TOL2_RS21570
uniprot id: K0NT47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

651182:TOL2 RS03585
gene id: 651182:TOL2_RS03585
uniprot id: K0ND47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS21240
gene id: 651182:TOL2_RS21240
uniprot id: K0NPT2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

651182:TOL2 RS04780
gene id: 651182:TOL2_RS04780
uniprot id: K0NE30
names: Function
names: Similarity
messages: Belongs to the peptidase S9C family.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

651182:TOL2 RS21445
gene id: 651182:TOL2_RS21445
uniprot id: K0NPW6
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS06580
gene id: 651182:TOL2_RS06580
uniprot id: K0N5P6
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS10660
gene id: 651182:TOL2_RS10660
uniprot id: K0N8C1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

651182:TOL2 RS00895
gene id: 651182:TOL2_RS00895
uniprot id: K0NC26
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

651182:TOL2 RS19065
gene id: 651182:TOL2_RS19065
uniprot id: K0NRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

651182:TOL2 RS21010
gene id: 651182:TOL2_RS21010
uniprot id: K0NNB3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

651182:TOL2 RS00020
gene id: 651182:TOL2_RS00020
uniprot id: K0N1X9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS17545
gene id: 651182:TOL2_RS17545
uniprot id: K0NB13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

651182:TOL2 RS02845
gene id: 651182:TOL2_RS02845
uniprot id: K0NI85
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS22135
gene id: 651182:TOL2_RS22135
uniprot id: K0NL75
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS04665
gene id: 651182:TOL2_RS04665
uniprot id: K0N4J5
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

651182:TOL2 RS01430
gene id: 651182:TOL2_RS01430
uniprot id: K0NCL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

651182:TOL2 RS11070
gene id: 651182:TOL2_RS11070
uniprot id: K0NJZ6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS02130
gene id: 651182:TOL2_RS02130
uniprot id: K0NCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS23785
gene id: 651182:TOL2_RS23785
uniprot id: K0NIT3
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05845
gene id: 651182:TOL2_RS05845
uniprot id: K0NKC9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

651182:TOL2 RS13115
gene id: 651182:TOL2_RS13115
uniprot id: K0NKZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

651182:TOL2 RS10605
gene id: 651182:TOL2_RS10605
uniprot id: K0NJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS11635
gene id: 651182:TOL2_RS11635
uniprot id: K0NK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

651182:TOL2 RS07795
gene id: 651182:TOL2_RS07795
uniprot id: K0N6J6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

651182:TOL2 RS16030
gene id: 651182:TOL2_RS16030
uniprot id: K0NJY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

651182:TOL2 RS08935
gene id: 651182:TOL2_RS08935
uniprot id: K0NFC8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

651182:TOL2 RS20875
gene id: 651182:TOL2_RS20875
uniprot id: K0NPM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

651182:TOL2 RS08580
gene id: 651182:TOL2_RS08580
uniprot id: K0NM27
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS03730
gene id: 651182:TOL2_RS03730
uniprot id: K0NGB2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS00605
gene id: 651182:TOL2_RS00605
uniprot id: K0NCA4
names: Similarity
messages: Belongs to the CvfB family.

651182:TOL2 RS07305
gene id: 651182:TOL2_RS07305
uniprot id: K0NI83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

651182:TOL2 RS16100
gene id: 651182:TOL2_RS16100
uniprot id: K0NMC2
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

651182:TOL2 RS13305
gene id: 651182:TOL2_RS13305
uniprot id: K0N9L6
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.

651182:TOL2 RS13410
gene id: 651182:TOL2_RS13410
uniprot id: K0N9M8
names: Function
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.

651182:TOL2 RS17290
gene id: 651182:TOL2_RS17290
uniprot id: K0NAY9
names: Similarity
messages: Belongs to the glutamate synthase family.

651182:TOL2 RS17355
gene id: 651182:TOL2_RS17355
uniprot id: K0NR50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

651182:TOL2 RS02455
gene id: 651182:TOL2_RS02455
uniprot id: K0NCP4
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS08175
gene id: 651182:TOL2_RS08175
uniprot id: K0NEX5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS15865
gene id: 651182:TOL2_RS15865
uniprot id: K0NAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS02545
gene id: 651182:TOL2_RS02545
uniprot id: K0NFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

651182:TOL2 RS22740
gene id: 651182:TOL2_RS22740
uniprot id: K0NP37
names: Similarity
messages: Belongs to the peptidase S41A family.

651182:TOL2 RS19070
gene id: 651182:TOL2_RS19070
uniprot id: K0NNU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

651182:TOL2 RS13210
gene id: 651182:TOL2_RS13210
uniprot id: K0NI56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

651182:TOL2 RS19840
gene id: 651182:TOL2_RS19840
uniprot id: K0NK31
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.

651182:TOL2 RS04725
gene id: 651182:TOL2_RS04725
uniprot id: K0NE20
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

651182:TOL2 RS00170
gene id: 651182:TOL2_RS00170
uniprot id: K0NGS8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

651182:TOL2 RS20205
gene id: 651182:TOL2_RS20205
uniprot id: K0NK81
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS18980
gene id: 651182:TOL2_RS18980
uniprot id: K0NLW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

651182:TOL2 RS15170
gene id: 651182:TOL2_RS15170
uniprot id: K0NHZ4
names: Similarity
messages: Belongs to the CFA/CMAS family.

651182:TOL2 RS14280
gene id: 651182:TOL2_RS14280
uniprot id: K0NLD6
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS15370
gene id: 651182:TOL2_RS15370
uniprot id: K0NI38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

651182:TOL2 RS01615
gene id: 651182:TOL2_RS01615
uniprot id: K0N2V9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS20755
gene id: 651182:TOL2_RS20755
uniprot id: K0NCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS08385
gene id: 651182:TOL2_RS08385
uniprot id: K0NFL5
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS03580
gene id: 651182:TOL2_RS03580
uniprot id: K0NDG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS02340
gene id: 651182:TOL2_RS02340
uniprot id: K0ND00
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS21945
gene id: 651182:TOL2_RS21945
uniprot id: K0NTA2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS09490
gene id: 651182:TOL2_RS09490
uniprot id: K0NJ78
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

651182:TOL2 RS07520
gene id: 651182:TOL2_RS07520
uniprot id: K0NFA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS20170
gene id: 651182:TOL2_RS20170
uniprot id: K0NBW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS02415
gene id: 651182:TOL2_RS02415
uniprot id: K0ND05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

651182:TOL2 RS11725
gene id: 651182:TOL2_RS11725
uniprot id: K0NGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

651182:TOL2 RS09305
gene id: 651182:TOL2_RS09305
uniprot id: K0N7G2
names: Similarity
messages: Belongs to the thioredoxin family.

651182:TOL2 RS13420
gene id: 651182:TOL2_RS13420
uniprot id: K0NI86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS04670
gene id: 651182:TOL2_RS04670
uniprot id: K0NE03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

651182:TOL2 RS03110
gene id: 651182:TOL2_RS03110
uniprot id: K0NIC8
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS10575
gene id: 651182:TOL2_RS10575
uniprot id: K0NN55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

651182:TOL2 RS05650
gene id: 651182:TOL2_RS05650
uniprot id: K0NEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS19790
gene id: 651182:TOL2_RS19790
uniprot id: K0NSB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

651182:TOL2 RS21720
gene id: 651182:TOL2_RS21720
uniprot id: K0NKY7
names: Similarity
messages: Belongs to the LOG family.

651182:TOL2 RS18495
gene id: 651182:TOL2_RS18495
uniprot id: K0NNM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

651182:TOL2 RS09745
gene id: 651182:TOL2_RS09745
uniprot id: K0NGE6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS15015
gene id: 651182:TOL2_RS15015
uniprot id: K0NJA3
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

651182:TOL2 RS11870
gene id: 651182:TOL2_RS11870
uniprot id: K0N8W4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

651182:TOL2 RS03115
gene id: 651182:TOL2_RS03115
uniprot id: K0NG28
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS16680
gene id: 651182:TOL2_RS16680
uniprot id: K0NQS3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

651182:TOL2 RS18580
gene id: 651182:TOL2_RS18580
uniprot id: K0NBF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

651182:TOL2 RS12580
gene id: 651182:TOL2_RS12580
uniprot id: K0NHU5
names: Similarity
messages: Belongs to the CFA/CMAS family.

651182:TOL2 RS20320
gene id: 651182:TOL2_RS20320
uniprot id: K0NC02
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS12960
gene id: 651182:TOL2_RS12960
uniprot id: K0NI26
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

651182:TOL2 RS18110
gene id: 651182:TOL2_RS18110
uniprot id: K0NLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS23025
gene id: 651182:TOL2_RS23025
uniprot id: K0NLW3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

651182:TOL2 RS02510
gene id: 651182:TOL2_RS02510
uniprot id: K0NI21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

651182:TOL2 RS15875
gene id: 651182:TOL2_RS15875
uniprot id: K0NIC1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

651182:TOL2 RS19965
gene id: 651182:TOL2_RS19965
uniprot id: K0NBU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

651182:TOL2 RS06775
gene id: 651182:TOL2_RS06775
uniprot id: K0N5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

651182:TOL2 RS01760
gene id: 651182:TOL2_RS01760
uniprot id: K0NFK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

651182:TOL2 RS19740
gene id: 651182:TOL2_RS19740
uniprot id: K0NP28
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

651182:TOL2 RS20140
gene id: 651182:TOL2_RS20140
uniprot id: K0NP87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

651182:TOL2 RS20325
gene id: 651182:TOL2_RS20325
uniprot id: K0NMW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS03790
gene id: 651182:TOL2_RS03790
uniprot id: K0NDK1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS21675
gene id: 651182:TOL2_RS21675
uniprot id: K0NT64
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

651182:TOL2 RS09795
gene id: 651182:TOL2_RS09795
uniprot id: K0NGF5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

651182:TOL2 RS15445
gene id: 651182:TOL2_RS15445
uniprot id: K0NJN2
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

651182:TOL2 RS03300
gene id: 651182:TOL2_RS03300
uniprot id: K0N3S8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS11035
gene id: 651182:TOL2_RS11035
uniprot id: K0NJZ2
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

651182:TOL2 RS21460
gene id: 651182:TOL2_RS21460
uniprot id: K0NKU6
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

651182:TOL2 RS07945
gene id: 651182:TOL2_RS07945
uniprot id: K0NIL7
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS19810
gene id: 651182:TOL2_RS19810
uniprot id: K0NK28
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

651182:TOL2 RS21255
gene id: 651182:TOL2_RS21255
uniprot id: K0NKR8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

651182:TOL2 RS04410
gene id: 651182:TOL2_RS04410
uniprot id: K0N4E0
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

651182:TOL2 RS18020
gene id: 651182:TOL2_RS18020
uniprot id: K0NRI3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

651182:TOL2 RS13720
gene id: 651182:TOL2_RS13720
uniprot id: K0NPE9
names: Similarity
messages: Belongs to the UPF0111 family.

651182:TOL2 RS14760
gene id: 651182:TOL2_RS14760
uniprot id: K0NHQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS20110
gene id: 651182:TOL2_RS20110
uniprot id: K0NSH3
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS02560
gene id: 651182:TOL2_RS02560
uniprot id: K0NCQ6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

651182:TOL2 RS18670
gene id: 651182:TOL2_RS18670
uniprot id: K0NJJ2
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

651182:TOL2 RS08945
gene id: 651182:TOL2_RS08945
uniprot id: K0NIZ5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

651182:TOL2 RS17900
gene id: 651182:TOL2_RS17900
uniprot id: K0NB74
names: Similarity
messages: Belongs to the UPF0102 family.

651182:TOL2 RS11520
gene id: 651182:TOL2_RS11520
uniprot id: K0NH52
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

651182:TOL2 RS11850
gene id: 651182:TOL2_RS11850
uniprot id: K0NHD7
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

651182:TOL2 RS23215
gene id: 651182:TOL2_RS23215
uniprot id: K0ND72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

651182:TOL2 RS10230
gene id: 651182:TOL2_RS10230
uniprot id: K0NGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

651182:TOL2 RS11960
gene id: 651182:TOL2_RS11960
uniprot id: K0NGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

651182:TOL2 RS14265
gene id: 651182:TOL2_RS14265
uniprot id: K0NHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS05620
gene id: 651182:TOL2_RS05620
uniprot id: K0NEA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS17855
gene id: 651182:TOL2_RS17855
uniprot id: K0NL72
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

651182:TOL2 RS22800
gene id: 651182:TOL2_RS22800
uniprot id: K0NLL6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS03945
gene id: 651182:TOL2_RS03945
uniprot id: K0NDB7
names: Similarity
messages: Belongs to the HupF/HypC family.

651182:TOL2 RS21380
gene id: 651182:TOL2_RS21380
uniprot id: K0NKT7
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

651182:TOL2 RS15400
gene id: 651182:TOL2_RS15400
uniprot id: K0NI51
names: Similarity
messages: Belongs to the HdrA family.

651182:TOL2 RS00745
gene id: 651182:TOL2_RS00745
uniprot id: K0N2C7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS10075
gene id: 651182:TOL2_RS10075
uniprot id: K0NMX9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS03210
gene id: 651182:TOL2_RS03210
uniprot id: K0NCZ0
names: Similarity
messages: Belongs to the bacterial secretin family.

651182:TOL2 RS01695
gene id: 651182:TOL2_RS01695
uniprot id: K0NCC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

651182:TOL2 RS22860
gene id: 651182:TOL2_RS22860
uniprot id: K0NQQ0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05780
gene id: 651182:TOL2_RS05780
uniprot id: K0N525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

651182:TOL2 RS05645
gene id: 651182:TOL2_RS05645
uniprot id: K0N503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS19175
gene id: 651182:TOL2_RS19175
uniprot id: K0NBN0
names: Similarity
messages: Belongs to the CutA family.

651182:TOL2 RS04480
gene id: 651182:TOL2_RS04480
uniprot id: K0NGM6
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

651182:TOL2 RS05670
gene id: 651182:TOL2_RS05670
uniprot id: K0N506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS03225
gene id: 651182:TOL2_RS03225
uniprot id: K0N3Q9
names: Similarity
messages: Belongs to the threonine synthase family.

651182:TOL2 RS09535
gene id: 651182:TOL2_RS09535
uniprot id: K0NJ87
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS13775
gene id: 651182:TOL2_RS13775
uniprot id: K0N9S6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS17090
gene id: 651182:TOL2_RS17090
uniprot id: K0NKP0
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

651182:TOL2 RS24460
gene id: 651182:TOL2_RS24460
uniprot id: K0NCG6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

651182:TOL2 RS20995
gene id: 651182:TOL2_RS20995
uniprot id: K0NSX6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

651182:TOL2 RS22920
gene id: 651182:TOL2_RS22920
uniprot id: K0ND16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

651182:TOL2 RS08500
gene id: 651182:TOL2_RS08500
uniprot id: K0NF23
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS03100
gene id: 651182:TOL2_RS03100
uniprot id: K0ND74
names: Similarity
messages: Belongs to the YggT family.

651182:TOL2 RS19120
gene id: 651182:TOL2_RS19120
uniprot id: K0NNU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

651182:TOL2 RS13120
gene id: 651182:TOL2_RS13120
uniprot id: K0N9J5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

651182:TOL2 RS19035
gene id: 651182:TOL2_RS19035
uniprot id: K0NJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

651182:TOL2 RS13180
gene id: 651182:TOL2_RS13180
uniprot id: K0N9K0
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

651182:TOL2 RS15880
gene id: 651182:TOL2_RS15880
uniprot id: K0NQE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

651182:TOL2 RS18295
gene id: 651182:TOL2_RS18295
uniprot id: K0NNK6
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

651182:TOL2 RS00930
gene id: 651182:TOL2_RS00930
uniprot id: K0NF70
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

651182:TOL2 RS17495
gene id: 651182:TOL2_RS17495
uniprot id: K0NB07
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

651182:TOL2 RS04245
gene id: 651182:TOL2_RS04245
uniprot id: K0NDR6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS19885
gene id: 651182:TOL2_RS19885
uniprot id: K0NBU1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

651182:TOL2 RS03130
gene id: 651182:TOL2_RS03130
uniprot id: K0NCX7
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

651182:TOL2 RS08025
gene id: 651182:TOL2_RS08025
uniprot id: K0N6P6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

651182:TOL2 RS21545
gene id: 651182:TOL2_RS21545
uniprot id: K0NT44
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS11300
gene id: 651182:TOL2_RS11300
uniprot id: K0N8M4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

651182:TOL2 RS02040
gene id: 651182:TOL2_RS02040
uniprot id: K0NFR0
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

651182:TOL2 RS10795
gene id: 651182:TOL2_RS10795
uniprot id: K0NG75
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

651182:TOL2 RS22930
gene id: 651182:TOL2_RS22930
uniprot id: K0NLR5
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18455
gene id: 651182:TOL2_RS18455
uniprot id: K0NBE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

651182:TOL2 RS00045
gene id: 651182:TOL2_RS00045
uniprot id: K0N1Y3
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

651182:TOL2 RS12975
gene id: 651182:TOL2_RS12975
uniprot id: K0NKY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS08800
gene id: 651182:TOL2_RS08800
uniprot id: K0NFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

651182:TOL2 RS08365
gene id: 651182:TOL2_RS08365
uniprot id: K0NF00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS08455
gene id: 651182:TOL2_RS08455
uniprot id: K0NIT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS11765
gene id: 651182:TOL2_RS11765
uniprot id: K0N8U6
names: Similarity
messages: Belongs to the MipA/OmpV family.

651182:TOL2 RS14495
gene id: 651182:TOL2_RS14495
uniprot id: K0NLG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS20530
gene id: 651182:TOL2_RS20530
uniprot id: K0NN23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

651182:TOL2 RS08940
gene id: 651182:TOL2_RS08940
uniprot id: K0NM79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

651182:TOL2 RS23840
gene id: 651182:TOL2_RS23840
uniprot id: K0NNS6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

651182:TOL2 RS06635
gene id: 651182:TOL2_RS06635
uniprot id: K0NEP0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS08870
gene id: 651182:TOL2_RS08870
uniprot id: K0NIY7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

651182:TOL2 RS19935
gene id: 651182:TOL2_RS19935
uniprot id: K0NP49
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

651182:TOL2 RS08950
gene id: 651182:TOL2_RS08950
uniprot id: K0N789
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06050
gene id: 651182:TOL2_RS06050
uniprot id: K0NHD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

651182:TOL2 RS23370
gene id: 651182:TOL2_RS23370
uniprot id: K0N3K4
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

651182:TOL2 RS22075
gene id: 651182:TOL2_RS22075
uniprot id: K0NQ82
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

651182:TOL2 RS13015
gene id: 651182:TOL2_RS13015
uniprot id: K0N9I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

651182:TOL2 RS05355
gene id: 651182:TOL2_RS05355
uniprot id: K0NE85
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

651182:TOL2 RS13200
gene id: 651182:TOL2_RS13200
uniprot id: K0NL11
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

651182:TOL2 RS09830
gene id: 651182:TOL2_RS09830
uniprot id: K0NMS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

651182:TOL2 RS17955
gene id: 651182:TOL2_RS17955
uniprot id: K0NLA1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS18510
gene id: 651182:TOL2_RS18510
uniprot id: K0NJH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

651182:TOL2 RS05895
gene id: 651182:TOL2_RS05895
uniprot id: K0NKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

651182:TOL2 RS01290
gene id: 651182:TOL2_RS01290
uniprot id: K0NC67
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS18025
gene id: 651182:TOL2_RS18025
uniprot id: K0NNH5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS17440
gene id: 651182:TOL2_RS17440
uniprot id: K0NN40
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

651182:TOL2 RS00855
gene id: 651182:TOL2_RS00855
uniprot id: K0NF63
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS18280
gene id: 651182:TOL2_RS18280
uniprot id: K0NLH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

651182:TOL2 RS02450
gene id: 651182:TOL2_RS02450
uniprot id: K0ND06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS20315
gene id: 651182:TOL2_RS20315
uniprot id: K0NPB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS08020
gene id: 651182:TOL2_RS08020
uniprot id: K0NIM5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

651182:TOL2 RS01485
gene id: 651182:TOL2_RS01485
uniprot id: K0NCL9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

651182:TOL2 RS18525
gene id: 651182:TOL2_RS18525
uniprot id: K0NBF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

651182:TOL2 RS09040
gene id: 651182:TOL2_RS09040
uniprot id: K0NMA6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS07770
gene id: 651182:TOL2_RS07770
uniprot id: K0N6J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

651182:TOL2 RS19745
gene id: 651182:TOL2_RS19745
uniprot id: K0NBT2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

651182:TOL2 RS09020
gene id: 651182:TOL2_RS09020
uniprot id: K0NJ03
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS03160
gene id: 651182:TOL2_RS03160
uniprot id: K0NCY3
names: Similarity
messages: Belongs to the FeoA family.
messages: Belongs to the Fur family.

651182:TOL2 RS15375
gene id: 651182:TOL2_RS15375
uniprot id: K0NQ79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

651182:TOL2 RS12280
gene id: 651182:TOL2_RS12280
uniprot id: K0NGS5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

651182:TOL2 RS04690
gene id: 651182:TOL2_RS04690
uniprot id: K0N4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS13190
gene id: 651182:TOL2_RS13190
uniprot id: K0NH95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

651182:TOL2 RS21305
gene id: 651182:TOL2_RS21305
uniprot id: K0NKS4
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

651182:TOL2 RS17895
gene id: 651182:TOL2_RS17895
uniprot id: K0NNB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

651182:TOL2 RS19115
gene id: 651182:TOL2_RS19115
uniprot id: K0NRZ7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

651182:TOL2 RS04295
gene id: 651182:TOL2_RS04295
uniprot id: K0NJ84
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS18875
gene id: 651182:TOL2_RS18875
uniprot id: K0NBJ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS04515
gene id: 651182:TOL2_RS04515
uniprot id: K0N4G4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

651182:TOL2 RS00730
gene id: 651182:TOL2_RS00730
uniprot id: K0NC13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS07980
gene id: 651182:TOL2_RS07980
uniprot id: K0NFF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS18300
gene id: 651182:TOL2_RS18300
uniprot id: K0NBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS10145
gene id: 651182:TOL2_RS10145
uniprot id: K0N827
names: Similarity
messages: Belongs to the hemerythrin family.

651182:TOL2 RS20405
gene id: 651182:TOL2_RS20405
uniprot id: K0NMY5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

651182:TOL2 RS21830
gene id: 651182:TOL2_RS21830
uniprot id: K0NCL2
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

651182:TOL2 RS13855
gene id: 651182:TOL2_RS13855
uniprot id: K0NIH1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

651182:TOL2 RS22815
gene id: 651182:TOL2_RS22815
uniprot id: K0NCZ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

651182:TOL2 RS14175
gene id: 651182:TOL2_RS14175
uniprot id: K0NHM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

651182:TOL2 RS20870
gene id: 651182:TOL2_RS20870
uniprot id: K0NSW2
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

651182:TOL2 RS22680
gene id: 651182:TOL2_RS22680
uniprot id: K0NQJ8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18910
gene id: 651182:TOL2_RS18910
uniprot id: K0NJM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

651182:TOL2 RS15850
gene id: 651182:TOL2_RS15850
uniprot id: K0NIB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS05955
gene id: 651182:TOL2_RS05955
uniprot id: K0N558
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS21940
gene id: 651182:TOL2_RS21940
uniprot id: K0NL29
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS09820
gene id: 651182:TOL2_RS09820
uniprot id: K0NGF9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS06435
gene id: 651182:TOL2_RS06435
uniprot id: K0NEB0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

651182:TOL2 RS07340
gene id: 651182:TOL2_RS07340
uniprot id: K0NF10
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

651182:TOL2 RS02740
gene id: 651182:TOL2_RS02740
uniprot id: K0NI70
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

651182:TOL2 RS22125
gene id: 651182:TOL2_RS22125
uniprot id: K0NCQ1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS21200
gene id: 651182:TOL2_RS21200
uniprot id: K0NND3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

651182:TOL2 RS18590
gene id: 651182:TOL2_RS18590
uniprot id: K0NJI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

651182:TOL2 RS22600
gene id: 651182:TOL2_RS22600
uniprot id: K0NLH1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

651182:TOL2 RS02550
gene id: 651182:TOL2_RS02550
uniprot id: K0N3D4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

651182:TOL2 RS16045
gene id: 651182:TOL2_RS16045
uniprot id: K0NMB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

651182:TOL2 RS07255
gene id: 651182:TOL2_RS07255
uniprot id: K0N667
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

651182:TOL2 RS02525
gene id: 651182:TOL2_RS02525
uniprot id: K0ND14
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

651182:TOL2 RS10110
gene id: 651182:TOL2_RS10110
uniprot id: K0N822
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS07010
gene id: 651182:TOL2_RS07010
uniprot id: K0NI25
names: Similarity
messages: Belongs to the elongation factor P family.

651182:TOL2 RS10390
gene id: 651182:TOL2_RS10390
uniprot id: K0NG32
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS20595
gene id: 651182:TOL2_RS20595
uniprot id: K0NPG8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS07990
gene id: 651182:TOL2_RS07990
uniprot id: K0NLV0
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

651182:TOL2 RS14410
gene id: 651182:TOL2_RS14410
uniprot id: K0NHR3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS17550
gene id: 651182:TOL2_RS17550
uniprot id: K0NKZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

651182:TOL2 RS05240
gene id: 651182:TOL2_RS05240
uniprot id: K0NE73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

651182:TOL2 RS23085
gene id: 651182:TOL2_RS23085
uniprot id: K0NQV2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS20000
gene id: 651182:TOL2_RS20000
uniprot id: K0NML0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS04390
gene id: 651182:TOL2_RS04390
uniprot id: K0NDU1
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

651182:TOL2 RS20025
gene id: 651182:TOL2_RS20025
uniprot id: K0NML6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

651182:TOL2 RS09615
gene id: 651182:TOL2_RS09615
uniprot id: K0NMM8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

651182:TOL2 RS21785
gene id: 651182:TOL2_RS21785
uniprot id: K0NNM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

651182:TOL2 RS19735
gene id: 651182:TOL2_RS19735
uniprot id: K0NSA5
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

651182:TOL2 RS19130
gene id: 651182:TOL2_RS19130
uniprot id: K0NLY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

651182:TOL2 RS04080
gene id: 651182:TOL2_RS04080
uniprot id: K0NDP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

651182:TOL2 RS03735
gene id: 651182:TOL2_RS03735
uniprot id: K0N422
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS00415
gene id: 651182:TOL2_RS00415
uniprot id: K0NC82
names: Similarity
messages: Belongs to the UPF0251 family.

651182:TOL2 RS22795
gene id: 651182:TOL2_RS22795
uniprot id: K0NP45
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06685
gene id: 651182:TOL2_RS06685
uniprot id: K0NED8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS17690
gene id: 651182:TOL2_RS17690
uniprot id: K0NN83
names: Similarity
messages: Belongs to the UPF0751 family.

651182:TOL2 RS14030
gene id: 651182:TOL2_RS14030
uniprot id: K0NPI6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

651182:TOL2 RS04485
gene id: 651182:TOL2_RS04485
uniprot id: K0N4F7
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

651182:TOL2 RS10755
gene id: 651182:TOL2_RS10755
uniprot id: K0NJV2
names: Subcellular Location Annotation
messages: Cell outer membrane

651182:TOL2 RS03460
gene id: 651182:TOL2_RS03460
uniprot id: K0NII8
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS15990
gene id: 651182:TOL2_RS15990
uniprot id: K0NQG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

651182:TOL2 RS08360
gene id: 651182:TOL2_RS08360
uniprot id: K0NFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS18370
gene id: 651182:TOL2_RS18370
uniprot id: K0NRM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

651182:TOL2 RS02105
gene id: 651182:TOL2_RS02105
uniprot id: K0NCL4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS03955
gene id: 651182:TOL2_RS03955
uniprot id: K0NGE7
names: Similarity
messages: Belongs to the HypD family.

651182:TOL2 RS09850
gene id: 651182:TOL2_RS09850
uniprot id: K0NFU3
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

651182:TOL2 RS23805
gene id: 651182:TOL2_RS23805
uniprot id: K0NR44
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS07775
gene id: 651182:TOL2_RS07775
uniprot id: K0NFC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

651182:TOL2 RS13725
gene id: 651182:TOL2_RS13725
uniprot id: K0NL69
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS08705
gene id: 651182:TOL2_RS08705
uniprot id: K0NM48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

651182:TOL2 RS19575
gene id: 651182:TOL2_RS19575
uniprot id: K0NMB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

651182:TOL2 RS18100
gene id: 651182:TOL2_RS18100
uniprot id: K0NNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS18600
gene id: 651182:TOL2_RS18600
uniprot id: K0NNP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

651182:TOL2 RS07390
gene id: 651182:TOL2_RS07390
uniprot id: K0NF83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

651182:TOL2 RS13820
gene id: 651182:TOL2_RS13820
uniprot id: K0NL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS05130
gene id: 651182:TOL2_RS05130
uniprot id: K0NE63
names: Similarity
messages: Belongs to the PspA/IM30 family.

651182:TOL2 RS19045
gene id: 651182:TOL2_RS19045
uniprot id: K0NNT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

651182:TOL2 RS22260
gene id: 651182:TOL2_RS22260
uniprot id: K0NLA4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

651182:TOL2 RS06455
gene id: 651182:TOL2_RS06455
uniprot id: K0N5M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

651182:TOL2 RS20045
gene id: 651182:TOL2_RS20045
uniprot id: K0NBV2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

651182:TOL2 RS11955
gene id: 651182:TOL2_RS11955
uniprot id: K0NHG1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

651182:TOL2 RS02515
gene id: 651182:TOL2_RS02515
uniprot id: K0NFV7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

651182:TOL2 RS18995
gene id: 651182:TOL2_RS18995
uniprot id: K0NNT4
names: Similarity
messages: Belongs to the type III secretion exporter family.

651182:TOL2 RS05145
gene id: 651182:TOL2_RS05145
uniprot id: K0NGZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS19185
gene id: 651182:TOL2_RS19185
uniprot id: K0NJT3
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

651182:TOL2 RS03505
gene id: 651182:TOL2_RS03505
uniprot id: K0ND35
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

651182:TOL2 RS23425
gene id: 651182:TOL2_RS23425
uniprot id: K0NJK6
names: Subcellular Location Annotation
messages: Cell inner membrane

651182:TOL2 RS22825
gene id: 651182:TOL2_RS22825
uniprot id: K0NLM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

651182:TOL2 RS12115
gene id: 651182:TOL2_RS12115
uniprot id: K0NHJ7
names: Similarity
messages: Belongs to the TrpF family.

651182:TOL2 RS10545
gene id: 651182:TOL2_RS10545
uniprot id: K0NG48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

651182:TOL2 RS05040
gene id: 651182:TOL2_RS05040
uniprot id: K0NGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS07985
gene id: 651182:TOL2_RS07985
uniprot id: K0NEV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

651182:TOL2 RS15255
gene id: 651182:TOL2_RS15255
uniprot id: K0NLV9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

651182:TOL2 RS05945
gene id: 651182:TOL2_RS05945
uniprot id: K0NKG5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06175
gene id: 651182:TOL2_RS06175
uniprot id: K0NE83
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS19750
gene id: 651182:TOL2_RS19750
uniprot id: K0NMF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

651182:TOL2 RS22835
gene id: 651182:TOL2_RS22835
uniprot id: K0NQP3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

651182:TOL2 RS08780
gene id: 651182:TOL2_RS08780
uniprot id: K0NFA0
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

651182:TOL2 RS08815
gene id: 651182:TOL2_RS08815
uniprot id: K0NIY2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06655
gene id: 651182:TOL2_RS06655
uniprot id: K0N5R3
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

651182:TOL2 RS07375
gene id: 651182:TOL2_RS07375
uniprot id: K0NLI2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

651182:TOL2 RS20275
gene id: 651182:TOL2_RS20275
uniprot id: K0NMV6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

651182:TOL2 RS04470
gene id: 651182:TOL2_RS04470
uniprot id: K0NDM7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

651182:TOL2 RS13235
gene id: 651182:TOL2_RS13235
uniprot id: K0NI58
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

651182:TOL2 RS12325
gene id: 651182:TOL2_RS12325
uniprot id: K0NGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS21225
gene id: 651182:TOL2_RS21225
uniprot id: K0NND7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS18430
gene id: 651182:TOL2_RS18430
uniprot id: K0NBD9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

651182:TOL2 RS12160
gene id: 651182:TOL2_RS12160
uniprot id: K0NKG0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

651182:TOL2 RS06450
gene id: 651182:TOL2_RS06450
uniprot id: K0NHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

651182:TOL2 RS01300
gene id: 651182:TOL2_RS01300
uniprot id: K0NFC6
names: Similarity
messages: Belongs to the catalase family.

651182:TOL2 RS07800
gene id: 651182:TOL2_RS07800
uniprot id: K0NFD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

651182:TOL2 RS10785
gene id: 651182:TOL2_RS10785
uniprot id: K0N8F0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

651182:TOL2 RS03940
gene id: 651182:TOL2_RS03940
uniprot id: K0NDM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

651182:TOL2 RS14795
gene id: 651182:TOL2_RS14795
uniprot id: K0NLG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06780
gene id: 651182:TOL2_RS06780
uniprot id: K0NER0
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

651182:TOL2 RS23005
gene id: 651182:TOL2_RS23005
uniprot id: K0NTU3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

651182:TOL2 RS21980
gene id: 651182:TOL2_RS21980
uniprot id: K0NCN3
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS12235
gene id: 651182:TOL2_RS12235
uniprot id: K0NKH3
names: Similarity
messages: Belongs to the peptidase A24 family.

651182:TOL2 RS09865
gene id: 651182:TOL2_RS09865
uniprot id: K0N7U6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

651182:TOL2 RS23855
gene id: 651182:TOL2_RS23855
uniprot id: K0NP46
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

651182:TOL2 RS20005
gene id: 651182:TOL2_RS20005
uniprot id: K0NK54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

651182:TOL2 RS17860
gene id: 651182:TOL2_RS17860
uniprot id: K0NJ62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

651182:TOL2 RS20575
gene id: 651182:TOL2_RS20575
uniprot id: K0NC54
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS11810
gene id: 651182:TOL2_RS11810
uniprot id: K0NNL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

651182:TOL2 RS18000
gene id: 651182:TOL2_RS18000
uniprot id: K0NB92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

651182:TOL2 RS11995
gene id: 651182:TOL2_RS11995
uniprot id: K0NKD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

651182:TOL2 RS20920
gene id: 651182:TOL2_RS20920
uniprot id: K0NSW8
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

651182:TOL2 RS10885
gene id: 651182:TOL2_RS10885
uniprot id: K0NG85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

651182:TOL2 RS08785
gene id: 651182:TOL2_RS08785
uniprot id: K0NM58
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

651182:TOL2 RS08135
gene id: 651182:TOL2_RS08135
uniprot id: K0NIN9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS16690
gene id: 651182:TOL2_RS16690
uniprot id: K0NAT4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

651182:TOL2 RS07310
gene id: 651182:TOL2_RS07310
uniprot id: K0N681
names: Similarity
messages: Belongs to the RuvC family.

651182:TOL2 RS21220
gene id: 651182:TOL2_RS21220
uniprot id: K0NCF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

651182:TOL2 RS15295
gene id: 651182:TOL2_RS15295
uniprot id: K0NI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS10710
gene id: 651182:TOL2_RS10710
uniprot id: K0N8D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS21890
gene id: 651182:TOL2_RS21890
uniprot id: K0NL21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS11685
gene id: 651182:TOL2_RS11685
uniprot id: K0NK87
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS08680
gene id: 651182:TOL2_RS08680
uniprot id: K0NF84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

651182:TOL2 RS18505
gene id: 651182:TOL2_RS18505
uniprot id: K0NLK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

651182:TOL2 RS13490
gene id: 651182:TOL2_RS13490
uniprot id: K0NL45
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

651182:TOL2 RS22780
gene id: 651182:TOL2_RS22780
uniprot id: K0NTQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

651182:TOL2 RS11410
gene id: 651182:TOL2_RS11410
uniprot id: K0NGE2
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

651182:TOL2 RS12830
gene id: 651182:TOL2_RS12830
uniprot id: K0NI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS12965
gene id: 651182:TOL2_RS12965
uniprot id: K0NH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS09770
gene id: 651182:TOL2_RS09770
uniprot id: K0NGF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS22695
gene id: 651182:TOL2_RS22695
uniprot id: K0NLJ2
names: Similarity
messages: Belongs to the P(II) protein family.

651182:TOL2 RS02095
gene id: 651182:TOL2_RS02095
uniprot id: K0N372
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS04995
gene id: 651182:TOL2_RS04995
uniprot id: K0NE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS11990
gene id: 651182:TOL2_RS11990
uniprot id: K0NNQ0
names: Similarity
messages: Belongs to the MotB family.

651182:TOL2 RS05530
gene id: 651182:TOL2_RS05530
uniprot id: K0N4Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

651182:TOL2 RS12805
gene id: 651182:TOL2_RS12805
uniprot id: K0NI04
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS16145
gene id: 651182:TOL2_RS16145
uniprot id: K0NIF2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

651182:TOL2 RS22205
gene id: 651182:TOL2_RS22205
uniprot id: K0NNV1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

651182:TOL2 RS20465
gene id: 651182:TOL2_RS20465
uniprot id: K0NSM7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

651182:TOL2 RS07955
gene id: 651182:TOL2_RS07955
uniprot id: K0NFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

651182:TOL2 RS01605
gene id: 651182:TOL2_RS01605
uniprot id: K0NHK8
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

651182:TOL2 RS11305
gene id: 651182:TOL2_RS11305
uniprot id: K0NH16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

651182:TOL2 RS13215
gene id: 651182:TOL2_RS13215
uniprot id: K0NH99
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

651182:TOL2 RS19765
gene id: 651182:TOL2_RS19765
uniprot id: K0NP32
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

651182:TOL2 RS06185
gene id: 651182:TOL2_RS06185
uniprot id: K0NHG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS23625
gene id: 651182:TOL2_RS23625
uniprot id: K0NNG6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

651182:TOL2 RS01375
gene id: 651182:TOL2_RS01375
uniprot id: K0NFE1
names: Similarity
messages: Belongs to the leucine-binding protein family.

651182:TOL2 RS08685
gene id: 651182:TOL2_RS08685
uniprot id: K0NM38
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05120
gene id: 651182:TOL2_RS05120
uniprot id: K0NGY8
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

651182:TOL2 RS04675
gene id: 651182:TOL2_RS04675
uniprot id: K0NDR5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

651182:TOL2 RS14950
gene id: 651182:TOL2_RS14950
uniprot id: K0NJ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPS (TC 1.B.20) family.
messages: Cell outer membrane
messages: Membrane

651182:TOL2 RS07765
gene id: 651182:TOL2_RS07765
uniprot id: K0NIJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

651182:TOL2 RS06065
gene id: 651182:TOL2_RS06065
uniprot id: K0NE67
names: Similarity
messages: Belongs to the PhoH family.

651182:TOL2 RS09030
gene id: 651182:TOL2_RS09030
uniprot id: K0NFX0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS23550
gene id: 651182:TOL2_RS23550
uniprot id: K0NLX2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS06020
gene id: 651182:TOL2_RS06020
uniprot id: K0NKJ0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS05390
gene id: 651182:TOL2_RS05390
uniprot id: K0NDZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

651182:TOL2 RS20705
gene id: 651182:TOL2_RS20705
uniprot id: K0NC98
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

651182:TOL2 RS21230
gene id: 651182:TOL2_RS21230
uniprot id: K0NKR2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

651182:TOL2 RS17335
gene id: 651182:TOL2_RS17335
uniprot id: K0NN07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

651182:TOL2 RS00770
gene id: 651182:TOL2_RS00770
uniprot id: K0N2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

651182:TOL2 RS10600
gene id: 651182:TOL2_RS10600
uniprot id: K0NN58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

651182:TOL2 RS20790
gene id: 651182:TOL2_RS20790
uniprot id: K0NKI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

651182:TOL2 RS12740
gene id: 651182:TOL2_RS12740
uniprot id: K0NP36
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

651182:TOL2 RS25400
gene id: 651182:TOL2_RS25400
uniprot id: K0NH15
names: Subunit
messages: Homodimer.

651182:TOL2 RS18535
gene id: 651182:TOL2_RS18535
uniprot id: K0NJH9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

651182:TOL2 RS10705
gene id: 651182:TOL2_RS10705
uniprot id: K0NJU3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS09230
gene id: 651182:TOL2_RS09230
uniprot id: K0N7E4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

651182:TOL2 RS05360
gene id: 651182:TOL2_RS05360
uniprot id: K0NDY8
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

651182:TOL2 RS08440
gene id: 651182:TOL2_RS08440
uniprot id: K0NFM2
names: Subunit
messages: Heterodimer of a large and a small subunit.

651182:TOL2 RS03970
gene id: 651182:TOL2_RS03970
uniprot id: K0NDC3
names: Similarity
messages: Belongs to the UPF0166 family.

651182:TOL2 RS01635
gene id: 651182:TOL2_RS01635
uniprot id: K0NFI7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS12650
gene id: 651182:TOL2_RS12650
uniprot id: K0NKQ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

651182:TOL2 RS23115
gene id: 651182:TOL2_RS23115
uniprot id: K0ND49
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS12675
gene id: 651182:TOL2_RS12675
uniprot id: K0NKR4
names: Similarity
messages: Belongs to the DEAD box helicase family.

651182:TOL2 RS11735
gene id: 651182:TOL2_RS11735
uniprot id: K0NK91
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS14575
gene id: 651182:TOL2_RS14575
uniprot id: K0NLH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS16895
gene id: 651182:TOL2_RS16895
uniprot id: K0NAV5
names: Subunit
messages: Heterodimer of a large and a small subunit.

651182:TOL2 RS14810
gene id: 651182:TOL2_RS14810
uniprot id: K0NHR3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS09695
gene id: 651182:TOL2_RS09695
uniprot id: K0NFQ6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS01990
gene id: 651182:TOL2_RS01990
uniprot id: K0NFP5
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS01820
gene id: 651182:TOL2_RS01820
uniprot id: K0NCT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS18615
gene id: 651182:TOL2_RS18615
uniprot id: K0NJI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

651182:TOL2 RS05580
gene id: 651182:TOL2_RS05580
uniprot id: K0NH51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

651182:TOL2 RS17865
gene id: 651182:TOL2_RS17865
uniprot id: K0NRE9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

651182:TOL2 RS22380
gene id: 651182:TOL2_RS22380
uniprot id: K0NLC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

651182:TOL2 RS17520
gene id: 651182:TOL2_RS17520
uniprot id: K0NB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

651182:TOL2 RS18985
gene id: 651182:TOL2_RS18985
uniprot id: K0NJN4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

651182:TOL2 RS02785
gene id: 651182:TOL2_RS02785
uniprot id: K0ND41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

651182:TOL2 RS19860
gene id: 651182:TOL2_RS19860
uniprot id: K0NMH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS17715
gene id: 651182:TOL2_RS17715
uniprot id: K0NN88
names: Similarity
messages: Belongs to the heat shock protein 70 family.

651182:TOL2 RS20715
gene id: 651182:TOL2_RS20715
uniprot id: K0NKI0
names: Similarity
messages: Belongs to the citrate synthase family.

651182:TOL2 RS23135
gene id: 651182:TOL2_RS23135
uniprot id: K0NQW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

651182:TOL2 RS15145
gene id: 651182:TOL2_RS15145
uniprot id: K0NHZ0
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

651182:TOL2 RS15270
gene id: 651182:TOL2_RS15270
uniprot id: K0NI18
names: Similarity
messages: Belongs to the P(II) protein family.

651182:TOL2 RS10455
gene id: 651182:TOL2_RS10455
uniprot id: K0N894
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS03925
gene id: 651182:TOL2_RS03925
uniprot id: K0NIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

651182:TOL2 RS10685
gene id: 651182:TOL2_RS10685
uniprot id: K0N8C6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

651182:TOL2 RS06545
gene id: 651182:TOL2_RS06545
uniprot id: K0NKW5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS07825
gene id: 651182:TOL2_RS07825
uniprot id: K0NFD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

651182:TOL2 RS08000
gene id: 651182:TOL2_RS08000
uniprot id: K0N6P2
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS21165
gene id: 651182:TOL2_RS21165
uniprot id: K0NPS0
names: Similarity
messages: Belongs to the GcvT family.

651182:TOL2 RS04420
gene id: 651182:TOL2_RS04420
uniprot id: K0NDL7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

651182:TOL2 RS11325
gene id: 651182:TOL2_RS11325
uniprot id: K0N8M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

651182:TOL2 RS13450
gene id: 651182:TOL2_RS13450
uniprot id: K0NI89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

651182:TOL2 RS12060
gene id: 651182:TOL2_RS12060
uniprot id: K0NGP1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

651182:TOL2 RS21145
gene id: 651182:TOL2_RS21145
uniprot id: K0NCE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS03230
gene id: 651182:TOL2_RS03230
uniprot id: K0ND93
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06210
gene id: 651182:TOL2_RS06210
uniprot id: K0NHG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS07350
gene id: 651182:TOL2_RS07350
uniprot id: K0NLG9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

651182:TOL2 RS10770
gene id: 651182:TOL2_RS10770
uniprot id: K0NG72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS22250
gene id: 651182:TOL2_RS22250
uniprot id: K0NCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS01395
gene id: 651182:TOL2_RS01395
uniprot id: K0NFE9
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

651182:TOL2 RS17840
gene id: 651182:TOL2_RS17840
uniprot id: K0NRE5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS10570
gene id: 651182:TOL2_RS10570
uniprot id: K0NG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

651182:TOL2 RS02625
gene id: 651182:TOL2_RS02625
uniprot id: K0N3F0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

651182:TOL2 RS20665
gene id: 651182:TOL2_RS20665
uniprot id: K0NST7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

651182:TOL2 RS07495
gene id: 651182:TOL2_RS07495
uniprot id: K0NEQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

651182:TOL2 RS19995
gene id: 651182:TOL2_RS19995
uniprot id: K0NBU6
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

651182:TOL2 RS18490
gene id: 651182:TOL2_RS18490
uniprot id: K0NJH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

651182:TOL2 RS07065
gene id: 651182:TOL2_RS07065
uniprot id: K0N617
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

651182:TOL2 RS21275
gene id: 651182:TOL2_RS21275
uniprot id: K0NNE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS13455
gene id: 651182:TOL2_RS13455
uniprot id: K0NHC2
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

651182:TOL2 RS16835
gene id: 651182:TOL2_RS16835
uniprot id: K0NQU9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS13010
gene id: 651182:TOL2_RS13010
uniprot id: K0NKY6
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

651182:TOL2 RS10560
gene id: 651182:TOL2_RS10560
uniprot id: K0N8B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

651182:TOL2 RS22805
gene id: 651182:TOL2_RS22805
uniprot id: K0NTQ4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

651182:TOL2 RS06900
gene id: 651182:TOL2_RS06900
uniprot id: K0NL50
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

651182:TOL2 RS21745
gene id: 651182:TOL2_RS21745
uniprot id: K0NKZ2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS07140
gene id: 651182:TOL2_RS07140
uniprot id: K0NI45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS13020
gene id: 651182:TOL2_RS13020
uniprot id: K0NI35
names: Similarity
messages: Belongs to the Ahb/Nir family.

651182:TOL2 RS03700
gene id: 651182:TOL2_RS03700
uniprot id: K0NIN7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

651182:TOL2 RS05885
gene id: 651182:TOL2_RS05885
uniprot id: K0NED5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

651182:TOL2 RS09635
gene id: 651182:TOL2_RS09635
uniprot id: K0NFP6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

651182:TOL2 RS00670
gene id: 651182:TOL2_RS00670
uniprot id: K0NCB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

651182:TOL2 RS22950
gene id: 651182:TOL2_RS22950
uniprot id: K0NP67
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

651182:TOL2 RS17470
gene id: 651182:TOL2_RS17470
uniprot id: K0NB04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

651182:TOL2 RS22435
gene id: 651182:TOL2_RS22435
uniprot id: K0NTJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS20860
gene id: 651182:TOL2_RS20860
uniprot id: K0NN99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS07745
gene id: 651182:TOL2_RS07745
uniprot id: K0N6I7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

651182:TOL2 RS07385
gene id: 651182:TOL2_RS07385
uniprot id: K0N6A2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

651182:TOL2 RS12170
gene id: 651182:TOL2_RS12170
uniprot id: K0NHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

651182:TOL2 RS18075
gene id: 651182:TOL2_RS18075
uniprot id: K0NNI2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

651182:TOL2 RS00005
gene id: 651182:TOL2_RS00005
uniprot id: K0NBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

651182:TOL2 RS02160
gene id: 651182:TOL2_RS02160
uniprot id: K0NHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS15360
gene id: 651182:TOL2_RS15360
uniprot id: K0NAG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

651182:TOL2 RS18565
gene id: 651182:TOL2_RS18565
uniprot id: K0NNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

651182:TOL2 RS14685
gene id: 651182:TOL2_RS14685
uniprot id: K0NLH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS16860
gene id: 651182:TOL2_RS16860
uniprot id: K0NQV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

651182:TOL2 RS18950
gene id: 651182:TOL2_RS18950
uniprot id: K0NBK0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

651182:TOL2 RS09320
gene id: 651182:TOL2_RS09320
uniprot id: K0NMG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.
messages: Homodimer.

651182:TOL2 RS05855
gene id: 651182:TOL2_RS05855
uniprot id: K0N540
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

651182:TOL2 RS20750
gene id: 651182:TOL2_RS20750
uniprot id: K0NPL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS11400
gene id: 651182:TOL2_RS11400
uniprot id: K0N8P1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

651182:TOL2 RS09430
gene id: 651182:TOL2_RS09430
uniprot id: K0NMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS19800
gene id: 651182:TOL2_RS19800
uniprot id: K0NBT6
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

651182:TOL2 RS01175
gene id: 651182:TOL2_RS01175
uniprot id: K0NH97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS12755
gene id: 651182:TOL2_RS12755
uniprot id: K0NHY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

651182:TOL2 RS22185
gene id: 651182:TOL2_RS22185
uniprot id: K0NL87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS05765
gene id: 651182:TOL2_RS05765
uniprot id: K0NE24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS19085
gene id: 651182:TOL2_RS19085
uniprot id: K0NJR0
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

651182:TOL2 RS21765
gene id: 651182:TOL2_RS21765
uniprot id: K0NNL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS01980
gene id: 651182:TOL2_RS01980
uniprot id: K0NCI0
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS05050
gene id: 651182:TOL2_RS05050
uniprot id: K0NE57
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

651182:TOL2 RS06500
gene id: 651182:TOL2_RS06500
uniprot id: K0NHQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

651182:TOL2 RS08145
gene id: 651182:TOL2_RS08145
uniprot id: K0NFH6
names: Similarity
messages: Belongs to the group II decarboxylase family.

651182:TOL2 RS10745
gene id: 651182:TOL2_RS10745
uniprot id: K0NG68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

651182:TOL2 RS06465
gene id: 651182:TOL2_RS06465
uniprot id: K0NEB2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

651182:TOL2 RS01640
gene id: 651182:TOL2_RS01640
uniprot id: K0N2W4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

651182:TOL2 RS08980
gene id: 651182:TOL2_RS08980
uniprot id: K0NFW1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS15605
gene id: 651182:TOL2_RS15605
uniprot id: K0NQB8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS12010
gene id: 651182:TOL2_RS12010
uniprot id: K0NGN5
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS10175
gene id: 651182:TOL2_RS10175
uniprot id: K0NGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS08755
gene id: 651182:TOL2_RS08755
uniprot id: K0NF96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

651182:TOL2 RS11285
gene id: 651182:TOL2_RS11285
uniprot id: K0NGC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

651182:TOL2 RS12270
gene id: 651182:TOL2_RS12270
uniprot id: K0N924
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

651182:TOL2 RS23060
gene id: 651182:TOL2_RS23060
uniprot id: K0NFR4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

651182:TOL2 RS07400
gene id: 651182:TOL2_RS07400
uniprot id: K0NLL9
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

651182:TOL2 RS10780
gene id: 651182:TOL2_RS10780
uniprot id: K0NJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

651182:TOL2 RS08790
gene id: 651182:TOL2_RS08790
uniprot id: K0NIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

651182:TOL2 RS00035
gene id: 651182:TOL2_RS00035
uniprot id: K0NGR4
names: Similarity
messages: Belongs to the CobH/CbiC family.

651182:TOL2 RS20255
gene id: 651182:TOL2_RS20255
uniprot id: K0NK88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Cytoplasm

651182:TOL2 RS15915
gene id: 651182:TOL2_RS15915
uniprot id: K0NM90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

651182:TOL2 RS12655
gene id: 651182:TOL2_RS12655
uniprot id: K0N9A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

651182:TOL2 RS17595
gene id: 651182:TOL2_RS17595
uniprot id: K0NB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS13205
gene id: 651182:TOL2_RS13205
uniprot id: K0N9K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

651182:TOL2 RS13220
gene id: 651182:TOL2_RS13220
uniprot id: K0NP98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

651182:TOL2 RS21990
gene id: 651182:TOL2_RS21990
uniprot id: K0NL43
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS17575
gene id: 651182:TOL2_RS17575
uniprot id: K0NKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS17165
gene id: 651182:TOL2_RS17165
uniprot id: K0NKR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

651182:TOL2 RS03165
gene id: 651182:TOL2_RS03165
uniprot id: K0NID5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

651182:TOL2 RS07410
gene id: 651182:TOL2_RS07410
uniprot id: K0N6C8
names: Similarity
messages: Belongs to the peptidase M18 family.

651182:TOL2 RS18710
gene id: 651182:TOL2_RS18710
uniprot id: K0NBH4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS17950
gene id: 651182:TOL2_RS17950
uniprot id: K0NB83
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

651182:TOL2 RS07315
gene id: 651182:TOL2_RS07315
uniprot id: K0NF07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

651182:TOL2 RS03850
gene id: 651182:TOL2_RS03850
uniprot id: K0NIR6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS18470
gene id: 651182:TOL2_RS18470
uniprot id: K0NRP3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

651182:TOL2 RS04825
gene id: 651182:TOL2_RS04825
uniprot id: K0N4N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS12480
gene id: 651182:TOL2_RS12480
uniprot id: K0NGW6
names: Similarity
messages: Belongs to the asparagine synthetase family.

651182:TOL2 RS19875
gene id: 651182:TOL2_RS19875
uniprot id: K0NSD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

651182:TOL2 RS15420
gene id: 651182:TOL2_RS15420
uniprot id: K0NJM4
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

651182:TOL2 RS15070
gene id: 651182:TOL2_RS15070
uniprot id: K0NHX8
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS20010
gene id: 651182:TOL2_RS20010
uniprot id: K0NSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS20840
gene id: 651182:TOL2_RS20840
uniprot id: K0NKJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.
messages: Periplasm

651182:TOL2 RS12670
gene id: 651182:TOL2_RS12670
uniprot id: K0NP26
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

651182:TOL2 RS09500
gene id: 651182:TOL2_RS09500
uniprot id: K0NG90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS19615
gene id: 651182:TOL2_RS19615
uniprot id: K0NBS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS09425
gene id: 651182:TOL2_RS09425
uniprot id: K0NFL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

651182:TOL2 RS14895
gene id: 651182:TOL2_RS14895
uniprot id: K0NLH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS07285
gene id: 651182:TOL2_RS07285
uniprot id: K0N674
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

651182:TOL2 RS05680
gene id: 651182:TOL2_RS05680
uniprot id: K0NE16
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

651182:TOL2 RS19915
gene id: 651182:TOL2_RS19915
uniprot id: K0NMI4
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS04655
gene id: 651182:TOL2_RS04655
uniprot id: K0NJF5
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

651182:TOL2 RS13705
gene id: 651182:TOL2_RS13705
uniprot id: K0NIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

651182:TOL2 RS02810
gene id: 651182:TOL2_RS02810
uniprot id: K0ND45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

651182:TOL2 RS23240
gene id: 651182:TOL2_RS23240
uniprot id: K0ND76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS10525
gene id: 651182:TOL2_RS10525
uniprot id: K0NN49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

651182:TOL2 RS06395
gene id: 651182:TOL2_RS06395
uniprot id: K0NHK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

651182:TOL2 RS11760
gene id: 651182:TOL2_RS11760
uniprot id: K0NK94
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS18920
gene id: 651182:TOL2_RS18920
uniprot id: K0NNS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

651182:TOL2 RS10315
gene id: 651182:TOL2_RS10315
uniprot id: K0NG23
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS09700
gene id: 651182:TOL2_RS09700
uniprot id: K0NMP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

651182:TOL2 RS16095
gene id: 651182:TOL2_RS16095
uniprot id: K0NQH0
names: Similarity
messages: Belongs to the AlaDH/PNT family.

651182:TOL2 RS19975
gene id: 651182:TOL2_RS19975
uniprot id: K0NK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

651182:TOL2 RS12225
gene id: 651182:TOL2_RS12225
uniprot id: K0NGR6
names: Similarity
messages: Belongs to the bacterial secretin family.

651182:TOL2 RS03835
gene id: 651182:TOL2_RS03835
uniprot id: K0N447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

651182:TOL2 RS21680
gene id: 651182:TOL2_RS21680
uniprot id: K0NQ04
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS13285
gene id: 651182:TOL2_RS13285
uniprot id: K0NI65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

651182:TOL2 RS12190
gene id: 651182:TOL2_RS12190
uniprot id: K0N912
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS17910
gene id: 651182:TOL2_RS17910
uniprot id: K0NJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

651182:TOL2 RS20955
gene id: 651182:TOL2_RS20955
uniprot id: K0NCC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS21790
gene id: 651182:TOL2_RS21790
uniprot id: K0NL00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

651182:TOL2 RS07365
gene id: 651182:TOL2_RS07365
uniprot id: K0NF14
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

651182:TOL2 RS14585
gene id: 651182:TOL2_RS14585
uniprot id: K0NLG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS00750
gene id: 651182:TOL2_RS00750
uniprot id: K0NCC3
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS16675
gene id: 651182:TOL2_RS16675
uniprot id: K0NIM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

651182:TOL2 RS02430
gene id: 651182:TOL2_RS02430
uniprot id: K0NFU7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

651182:TOL2 RS08425
gene id: 651182:TOL2_RS08425
uniprot id: K0NM07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

651182:TOL2 RS12455
gene id: 651182:TOL2_RS12455
uniprot id: K0NGW2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

651182:TOL2 RS20805
gene id: 651182:TOL2_RS20805
uniprot id: K0NCB0
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS05215
gene id: 651182:TOL2_RS05215
uniprot id: K0NE71
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

651182:TOL2 RS03095
gene id: 651182:TOL2_RS03095
uniprot id: K0N3N1
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS10765
gene id: 651182:TOL2_RS10765
uniprot id: K0NGT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

651182:TOL2 RS19345
gene id: 651182:TOL2_RS19345
uniprot id: K0NS32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

651182:TOL2 RS06480
gene id: 651182:TOL2_RS06480
uniprot id: K0N5M9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

651182:TOL2 RS02565
gene id: 651182:TOL2_RS02565
uniprot id: K0NI31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

651182:TOL2 RS18485
gene id: 651182:TOL2_RS18485
uniprot id: K0NLK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

651182:TOL2 RS20535
gene id: 651182:TOL2_RS20535
uniprot id: K0NKD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

651182:TOL2 RS11440
gene id: 651182:TOL2_RS11440
uniprot id: K0NGE5
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

651182:TOL2 RS12820
gene id: 651182:TOL2_RS12820
uniprot id: K0NKW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS12290
gene id: 651182:TOL2_RS12290
uniprot id: K0NKI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

651182:TOL2 RS04090
gene id: 651182:TOL2_RS04090
uniprot id: K0NDE6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

651182:TOL2 RS17990
gene id: 651182:TOL2_RS17990
uniprot id: K0NRG8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

651182:TOL2 RS07755
gene id: 651182:TOL2_RS07755
uniprot id: K0NET5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

651182:TOL2 RS04945
gene id: 651182:TOL2_RS04945
uniprot id: K0NDV4
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

651182:TOL2 RS02000
gene id: 651182:TOL2_RS02000
uniprot id: K0NCV3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS18260
gene id: 651182:TOL2_RS18260
uniprot id: K0NJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS18460
gene id: 651182:TOL2_RS18460
uniprot id: K0NLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

651182:TOL2 RS23190
gene id: 651182:TOL2_RS23190
uniprot id: K0ND60
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

651182:TOL2 RS11940
gene id: 651182:TOL2_RS11940
uniprot id: K0NNN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

651182:TOL2 RS05410
gene id: 651182:TOL2_RS05410
uniprot id: K0NE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

651182:TOL2 RS15805
gene id: 651182:TOL2_RS15805
uniprot id: K0NIB3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

651182:TOL2 RS15690
gene id: 651182:TOL2_RS15690
uniprot id: K0NM45
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

651182:TOL2 RS09525
gene id: 651182:TOL2_RS09525
uniprot id: K0NFN2
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

651182:TOL2 RS10790
gene id: 651182:TOL2_RS10790
uniprot id: K0NGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS06515
gene id: 651182:TOL2_RS06515
uniprot id: K0NEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

651182:TOL2 RS23360
gene id: 651182:TOL2_RS23360
uniprot id: K0NFZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06165
gene id: 651182:TOL2_RS06165
uniprot id: K0N5A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

651182:TOL2 RS01410
gene id: 651182:TOL2_RS01410
uniprot id: K0NC84
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

651182:TOL2 RS21055
gene id: 651182:TOL2_RS21055
uniprot id: K0NCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

651182:TOL2 RS15135
gene id: 651182:TOL2_RS15135
uniprot id: K0NAD2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

651182:TOL2 RS17515
gene id: 651182:TOL2_RS17515
uniprot id: K0NN54
names: Similarity
messages: Belongs to the FeoA family.

651182:TOL2 RS07185
gene id: 651182:TOL2_RS07185
uniprot id: K0NEK3
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS05900
gene id: 651182:TOL2_RS05900
uniprot id: K0NHB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS05435
gene id: 651182:TOL2_RS05435
uniprot id: K0NE94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS06445
gene id: 651182:TOL2_RS06445
uniprot id: K0NKU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

651182:TOL2 RS17875
gene id: 651182:TOL2_RS17875
uniprot id: K0NB67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

651182:TOL2 RS01915
gene id: 651182:TOL2_RS01915
uniprot id: K0N325
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

651182:TOL2 RS03250
gene id: 651182:TOL2_RS03250
uniprot id: K0N3R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

651182:TOL2 RS10700
gene id: 651182:TOL2_RS10700
uniprot id: K0NN64
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

651182:TOL2 RS23045
gene id: 651182:TOL2_RS23045
uniprot id: K0NP88
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

651182:TOL2 RS04815
gene id: 651182:TOL2_RS04815
uniprot id: K0NJL7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS23035
gene id: 651182:TOL2_RS23035
uniprot id: K0NQU4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

651182:TOL2 RS20835
gene id: 651182:TOL2_RS20835
uniprot id: K0NN95
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

651182:TOL2 RS17890
gene id: 651182:TOL2_RS17890
uniprot id: K0NRF3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

651182:TOL2 RS09655
gene id: 651182:TOL2_RS09655
uniprot id: K0N7P1
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

651182:TOL2 RS20340
gene id: 651182:TOL2_RS20340
uniprot id: K0NPB9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS21475
gene id: 651182:TOL2_RS21475
uniprot id: K0NCH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

651182:TOL2 RS20770
gene id: 651182:TOL2_RS20770
uniprot id: K0NSV0
names: Similarity
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.

651182:TOL2 RS10635
gene id: 651182:TOL2_RS10635
uniprot id: K0N8B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

651182:TOL2 RS07430
gene id: 651182:TOL2_RS07430
uniprot id: K0NIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS19380
gene id: 651182:TOL2_RS19380
uniprot id: K0NBQ2
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

651182:TOL2 RS20220
gene id: 651182:TOL2_RS20220
uniprot id: K0NBY2
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS04395
gene id: 651182:TOL2_RS04395
uniprot id: K0NDK7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

651182:TOL2 RS20950
gene id: 651182:TOL2_RS20950
uniprot id: K0NPP0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS07155
gene id: 651182:TOL2_RS07155
uniprot id: K0NEK1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

651182:TOL2 RS20635
gene id: 651182:TOL2_RS20635
uniprot id: K0NKG2
names: Similarity
messages: Belongs to the UPF0045 family.

651182:TOL2 RS19845
gene id: 651182:TOL2_RS19845
uniprot id: K0NSC5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

651182:TOL2 RS14270
gene id: 651182:TOL2_RS14270
uniprot id: K0NPM7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

651182:TOL2 RS08560
gene id: 651182:TOL2_RS08560
uniprot id: K0NIV1
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS12645
gene id: 651182:TOL2_RS12645
uniprot id: K0NP22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

651182:TOL2 RS19630
gene id: 651182:TOL2_RS19630
uniprot id: K0NS85
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

651182:TOL2 RS11980
gene id: 651182:TOL2_RS11980
uniprot id: K0NHG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Belongs to the acylphosphatase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

651182:TOL2 RS09270
gene id: 651182:TOL2_RS09270
uniprot id: K0NMF7
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

651182:TOL2 RS10740
gene id: 651182:TOL2_RS10740
uniprot id: K0NGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

651182:TOL2 RS02975
gene id: 651182:TOL2_RS02975
uniprot id: K0NCV7
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

651182:TOL2 RS18395
gene id: 651182:TOL2_RS18395
uniprot id: K0NRM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

651182:TOL2 RS13245
gene id: 651182:TOL2_RS13245
uniprot id: K0NPA1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18345
gene id: 651182:TOL2_RS18345
uniprot id: K0NNL2
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS10800
gene id: 651182:TOL2_RS10800
uniprot id: K0NN74
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

651182:TOL2 RS18320
gene id: 651182:TOL2_RS18320
uniprot id: K0NNL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS07360
gene id: 651182:TOL2_RS07360
uniprot id: K0N696
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

651182:TOL2 RS22415
gene id: 651182:TOL2_RS22415
uniprot id: K0NQF6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS09115
gene id: 651182:TOL2_RS09115
uniprot id: K0NFG4
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS21650
gene id: 651182:TOL2_RS21650
uniprot id: K0NQ00
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS21295
gene id: 651182:TOL2_RS21295
uniprot id: K0NCG0
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

651182:TOL2 RS00390
gene id: 651182:TOL2_RS00390
uniprot id: K0NC79
names: Similarity
messages: Belongs to the thioredoxin family.

651182:TOL2 RS08030
gene id: 651182:TOL2_RS08030
uniprot id: K0NFG2
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

651182:TOL2 RS18560
gene id: 651182:TOL2_RS18560
uniprot id: K0NJI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

651182:TOL2 RS19785
gene id: 651182:TOL2_RS19785
uniprot id: K0NK24
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

651182:TOL2 RS15435
gene id: 651182:TOL2_RS15435
uniprot id: K0NM11
names: Similarity
messages: Belongs to the HdrA family.

651182:TOL2 RS04745
gene id: 651182:TOL2_RS04745
uniprot id: K0N4N0
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

651182:TOL2 RS00625
gene id: 651182:TOL2_RS00625
uniprot id: K0NF44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS02425
gene id: 651182:TOL2_RS02425
uniprot id: K0NI09
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

651182:TOL2 RS16905
gene id: 651182:TOL2_RS16905
uniprot id: K0NIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

651182:TOL2 RS01015
gene id: 651182:TOL2_RS01015
uniprot id: K0N2H9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

651182:TOL2 RS16790
gene id: 651182:TOL2_RS16790
uniprot id: K0NMN1
names: Similarity
messages: Belongs to the peptidase S49 family.

651182:TOL2 RS05630
gene id: 651182:TOL2_RS05630
uniprot id: K0NK75
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

651182:TOL2 RS04980
gene id: 651182:TOL2_RS04980
uniprot id: K0NJP7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS17475
gene id: 651182:TOL2_RS17475
uniprot id: K0NKX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS20905
gene id: 651182:TOL2_RS20905
uniprot id: K0NCC1
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

651182:TOL2 RS07225
gene id: 651182:TOL2_RS07225
uniprot id: K0N661
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

651182:TOL2 RS18015
gene id: 651182:TOL2_RS18015
uniprot id: K0NJA6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

651182:TOL2 RS19245
gene id: 651182:TOL2_RS19245
uniprot id: K0NNV9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

651182:TOL2 RS17345
gene id: 651182:TOL2_RS17345
uniprot id: K0NKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS11860
gene id: 651182:TOL2_RS11860
uniprot id: K0NNM3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

651182:TOL2 RS00010
gene id: 651182:TOL2_RS00010
uniprot id: K0NGR1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

651182:TOL2 RS02315
gene id: 651182:TOL2_RS02315
uniprot id: K0NCZ7
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS22280
gene id: 651182:TOL2_RS22280
uniprot id: K0NNW6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

651182:TOL2 RS18820
gene id: 651182:TOL2_RS18820
uniprot id: K0NBI8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

651182:TOL2 RS10280
gene id: 651182:TOL2_RS10280
uniprot id: K0NGM5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

651182:TOL2 RS18235
gene id: 651182:TOL2_RS18235
uniprot id: K0NJE0
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

651182:TOL2 RS21050
gene id: 651182:TOL2_RS21050
uniprot id: K0NPQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

651182:TOL2 RS10070
gene id: 651182:TOL2_RS10070
uniprot id: K0NFY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

651182:TOL2 RS09910
gene id: 651182:TOL2_RS09910
uniprot id: K0NMT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

651182:TOL2 RS09145
gene id: 651182:TOL2_RS09145
uniprot id: K0NMC8
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS11290
gene id: 651182:TOL2_RS11290
uniprot id: K0NND1
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

651182:TOL2 RS03820
gene id: 651182:TOL2_RS03820
uniprot id: K0ND83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

651182:TOL2 RS15925
gene id: 651182:TOL2_RS15925
uniprot id: K0NJX0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS06860
gene id: 651182:TOL2_RS06860
uniprot id: K0NL41
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

651182:TOL2 RS07210
gene id: 651182:TOL2_RS07210
uniprot id: K0NEK7
names: Similarity
messages: Belongs to the MotB family.

651182:TOL2 RS03975
gene id: 651182:TOL2_RS03975
uniprot id: K0NIU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

651182:TOL2 RS22925
gene id: 651182:TOL2_RS22925
uniprot id: K0NP63
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS08875
gene id: 651182:TOL2_RS08875
uniprot id: K0N771
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

651182:TOL2 RS18630
gene id: 651182:TOL2_RS18630
uniprot id: K0NNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

651182:TOL2 RS19195
gene id: 651182:TOL2_RS19195
uniprot id: K0NNV5
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

651182:TOL2 RS21845
gene id: 651182:TOL2_RS21845
uniprot id: K0NT88
names: Similarity
messages: Belongs to the hemerythrin family.

651182:TOL2 RS08975
gene id: 651182:TOL2_RS08975
uniprot id: K0N794
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS07020
gene id: 651182:TOL2_RS07020
uniprot id: K0NEU9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

651182:TOL2 RS19060
gene id: 651182:TOL2_RS19060
uniprot id: K0NJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

651182:TOL2 RS13750
gene id: 651182:TOL2_RS13750
uniprot id: K0N9S1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS01935
gene id: 651182:TOL2_RS01935
uniprot id: K0NFN8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

651182:TOL2 RS15450
gene id: 651182:TOL2_RS15450
uniprot id: K0NI66
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

651182:TOL2 RS12055
gene id: 651182:TOL2_RS12055
uniprot id: K0NHI5
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

651182:TOL2 RS03800
gene id: 651182:TOL2_RS03800
uniprot id: K0NIQ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS08765
gene id: 651182:TOL2_RS08765
uniprot id: K0NIX6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS08885
gene id: 651182:TOL2_RS08885
uniprot id: K0NFB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

651182:TOL2 RS07805
gene id: 651182:TOL2_RS07805
uniprot id: K0NEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

651182:TOL2 RS07480
gene id: 651182:TOL2_RS07480
uniprot id: K0NIG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

651182:TOL2 RS09035
gene id: 651182:TOL2_RS09035
uniprot id: K0NFE6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS02375
gene id: 651182:TOL2_RS02375
uniprot id: K0NCN9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS15715
gene id: 651182:TOL2_RS15715
uniprot id: K0NM49
names: Similarity
messages: Belongs to the leucine-binding protein family.

651182:TOL2 RS05515
gene id: 651182:TOL2_RS05515
uniprot id: K0NE02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

651182:TOL2 RS00110
gene id: 651182:TOL2_RS00110
uniprot id: K0N1Z4
names: Similarity
messages: Belongs to the UPF0758 family.

651182:TOL2 RS14400
gene id: 651182:TOL2_RS14400
uniprot id: K0NA17
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS10200
gene id: 651182:TOL2_RS10200
uniprot id: K0N835
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

651182:TOL2 RS03025
gene id: 651182:TOL2_RS03025
uniprot id: K0ND68
names: Similarity
messages: Belongs to the UDPGP type 2 family.

651182:TOL2 RS12195
gene id: 651182:TOL2_RS12195
uniprot id: K0NHL8
names: Similarity
messages: Belongs to the GSP E family.

651182:TOL2 RS01730
gene id: 651182:TOL2_RS01730
uniprot id: K0NHM6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

651182:TOL2 RS22210
gene id: 651182:TOL2_RS22210
uniprot id: K0NL93
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

651182:TOL2 RS10550
gene id: 651182:TOL2_RS10550
uniprot id: K0NN53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

651182:TOL2 RS06595
gene id: 651182:TOL2_RS06595
uniprot id: K0NKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

651182:TOL2 RS02895
gene id: 651182:TOL2_RS02895
uniprot id: K0NCU9
names: Similarity
messages: Belongs to the UPF0145 family.

651182:TOL2 RS10080
gene id: 651182:TOL2_RS10080
uniprot id: K0NJK5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

651182:TOL2 RS11370
gene id: 651182:TOL2_RS11370
uniprot id: K0NK43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS16745
gene id: 651182:TOL2_RS16745
uniprot id: K0NKC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS10555
gene id: 651182:TOL2_RS10555
uniprot id: K0NJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

651182:TOL2 RS05890
gene id: 651182:TOL2_RS05890
uniprot id: K0NE40
names: Similarity
messages: Belongs to the aspartokinase family.

651182:TOL2 RS01385
gene id: 651182:TOL2_RS01385
uniprot id: K0NCK3
names: Similarity
messages: Belongs to the peptidase M24B family.

651182:TOL2 RS22965
gene id: 651182:TOL2_RS22965
uniprot id: K0NQS5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

651182:TOL2 RS21290
gene id: 651182:TOL2_RS21290
uniprot id: K0NPT8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

651182:TOL2 RS18595
gene id: 651182:TOL2_RS18595
uniprot id: K0NRR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

651182:TOL2 RS15475
gene id: 651182:TOL2_RS15475
uniprot id: K0NI71
names: Similarity
messages: Belongs to the peptidase S1C family.

651182:TOL2 RS16115
gene id: 651182:TOL2_RS16115
uniprot id: K0NIE9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

651182:TOL2 RS01240
gene id: 651182:TOL2_RS01240
uniprot id: K0NFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS11190
gene id: 651182:TOL2_RS11190
uniprot id: K0NGZ9
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

651182:TOL2 RS11335
gene id: 651182:TOL2_RS11335
uniprot id: K0NGD1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

651182:TOL2 RS22730
gene id: 651182:TOL2_RS22730
uniprot id: K0NQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

651182:TOL2 RS08825
gene id: 651182:TOL2_RS08825
uniprot id: K0NFT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

651182:TOL2 RS03105
gene id: 651182:TOL2_RS03105
uniprot id: K0NCX4
names: Subcellular Location Annotation
messages: Cytoplasm

651182:TOL2 RS14955
gene id: 651182:TOL2_RS14955
uniprot id: K0NHW3
names: Similarity
messages: Belongs to the carbamate kinase family.

651182:TOL2 RS02065
gene id: 651182:TOL2_RS02065
uniprot id: K0NFR4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

651182:TOL2 RS07380
gene id: 651182:TOL2_RS07380
uniprot id: K0NIA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

651182:TOL2 RS02790
gene id: 651182:TOL2_RS02790
uniprot id: K0NCT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

651182:TOL2 RS02860
gene id: 651182:TOL2_RS02860
uniprot id: K0ND50
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06630
gene id: 651182:TOL2_RS06630
uniprot id: K0N5Q7
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

651182:TOL2 RS16120
gene id: 651182:TOL2_RS16120
uniprot id: K0NQH3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

651182:TOL2 RS21410
gene id: 651182:TOL2_RS21410
uniprot id: K0NKT9
names: Similarity
messages: Belongs to the PhoH family.

651182:TOL2 RS19080
gene id: 651182:TOL2_RS19080
uniprot id: K0NLY0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

651182:TOL2 RS04660
gene id: 651182:TOL2_RS04660
uniprot id: K0NGP9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

651182:TOL2 RS02900
gene id: 651182:TOL2_RS02900
uniprot id: K0NI95
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS10355
gene id: 651182:TOL2_RS10355
uniprot id: K0N872
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS17660
gene id: 651182:TOL2_RS17660
uniprot id: K0NRB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS20305
gene id: 651182:TOL2_RS20305
uniprot id: K0NK93
names: Similarity
messages: Belongs to the NAD synthetase family.

651182:TOL2 RS02800
gene id: 651182:TOL2_RS02800
uniprot id: K0NFY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS11330
gene id: 651182:TOL2_RS11330
uniprot id: K0NH22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

651182:TOL2 RS13055
gene id: 651182:TOL2_RS13055
uniprot id: K0NH79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS20765
gene id: 651182:TOL2_RS20765
uniprot id: K0NKI4
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

651182:TOL2 RS18440
gene id: 651182:TOL2_RS18440
uniprot id: K0NJG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

651182:TOL2 RS00925
gene id: 651182:TOL2_RS00925
uniprot id: K0NH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS14060
gene id: 651182:TOL2_RS14060
uniprot id: K0NLB1
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

651182:TOL2 RS10470
gene id: 651182:TOL2_RS10470
uniprot id: K0NN45
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18730
gene id: 651182:TOL2_RS18730
uniprot id: K0NNQ4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

651182:TOL2 RS05175
gene id: 651182:TOL2_RS05175
uniprot id: K0NGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

651182:TOL2 RS02060
gene id: 651182:TOL2_RS02060
uniprot id: K0NHW5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

651182:TOL2 RS06030
gene id: 651182:TOL2_RS06030
uniprot id: K0N570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

651182:TOL2 RS22355
gene id: 651182:TOL2_RS22355
uniprot id: K0NLC2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS18040
gene id: 651182:TOL2_RS18040
uniprot id: K0NJB5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

651182:TOL2 RS20555
gene id: 651182:TOL2_RS20555
uniprot id: K0NN32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

651182:TOL2 RS02700
gene id: 651182:TOL2_RS02700
uniprot id: K0N3G4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS17970
gene id: 651182:TOL2_RS17970
uniprot id: K0NND4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

651182:TOL2 RS14710
gene id: 651182:TOL2_RS14710
uniprot id: K0NHR3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS25525
gene id: 651182:TOL2_RS25525
uniprot id: K0N9R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

651182:TOL2 RS22275
gene id: 651182:TOL2_RS22275
uniprot id: K0NCS3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

651182:TOL2 RS15885
gene id: 651182:TOL2_RS15885
uniprot id: K0NM85
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

651182:TOL2 RS01875
gene id: 651182:TOL2_RS01875
uniprot id: K0NCF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

651182:TOL2 RS25485
gene id: 651182:TOL2_RS25485
uniprot id: K0NN30
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS17200
gene id: 651182:TOL2_RS17200
uniprot id: K0NIW4
names: Similarity
messages: Belongs to the PrpF family.

651182:TOL2 RS08285
gene id: 651182:TOL2_RS08285
uniprot id: K0NLZ2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

651182:TOL2 RS03665
gene id: 651182:TOL2_RS03665
uniprot id: K0ND59
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

651182:TOL2 RS16685
gene id: 651182:TOL2_RS16685
uniprot id: K0NML1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

651182:TOL2 RS02830
gene id: 651182:TOL2_RS02830
uniprot id: K0N3I7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

651182:TOL2 RS22450
gene id: 651182:TOL2_RS22450
uniprot id: K0NNZ6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

651182:TOL2 RS12185
gene id: 651182:TOL2_RS12185
uniprot id: K0NKG4
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS12815
gene id: 651182:TOL2_RS12815
uniprot id: K0NP58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS03960
gene id: 651182:TOL2_RS03960
uniprot id: K0N465
names: Similarity
messages: Belongs to the HypE family.

651182:TOL2 RS09410
gene id: 651182:TOL2_RS09410
uniprot id: K0N7I3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

651182:TOL2 RS08620
gene id: 651182:TOL2_RS08620
uniprot id: K0NFQ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS18585
gene id: 651182:TOL2_RS18585
uniprot id: K0NLM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

651182:TOL2 RS02435
gene id: 651182:TOL2_RS02435
uniprot id: K0N3B8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS09690
gene id: 651182:TOL2_RS09690
uniprot id: K0NGD6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

651182:TOL2 RS18705
gene id: 651182:TOL2_RS18705
uniprot id: K0NNQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

651182:TOL2 RS07575
gene id: 651182:TOL2_RS07575
uniprot id: K0NER5
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS15920
gene id: 651182:TOL2_RS15920
uniprot id: K0NAM6
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

651182:TOL2 RS15155
gene id: 651182:TOL2_RS15155
uniprot id: K0NLT5
names: Similarity
messages: Belongs to the HisA/HisF family.

651182:TOL2 RS11925
gene id: 651182:TOL2_RS11925
uniprot id: K0N8X2
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

651182:TOL2 RS08665
gene id: 651182:TOL2_RS08665
uniprot id: K0NIW5
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS07230
gene id: 651182:TOL2_RS07230
uniprot id: K0NEZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

651182:TOL2 RS10155
gene id: 651182:TOL2_RS10155
uniprot id: K0NG06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

651182:TOL2 RS21535
gene id: 651182:TOL2_RS21535
uniprot id: K0NNH4
names: Similarity
messages: Belongs to the PspA/IM30 family.

651182:TOL2 RS18270
gene id: 651182:TOL2_RS18270
uniprot id: K0NNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS03695
gene id: 651182:TOL2_RS03695
uniprot id: K0ND64
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS11345
gene id: 651182:TOL2_RS11345
uniprot id: K0NK39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Mitochondrion

651182:TOL2 RS06115
gene id: 651182:TOL2_RS06115
uniprot id: K0NEG7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

651182:TOL2 RS06530
gene id: 651182:TOL2_RS06530
uniprot id: K0N5N8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS21520
gene id: 651182:TOL2_RS21520
uniprot id: K0NPX8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS07555
gene id: 651182:TOL2_RS07555
uniprot id: K0NER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

651182:TOL2 RS18445
gene id: 651182:TOL2_RS18445
uniprot id: K0NRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

651182:TOL2 RS21135
gene id: 651182:TOL2_RS21135
uniprot id: K0NSZ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS02805
gene id: 651182:TOL2_RS02805
uniprot id: K0N3I4
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

651182:TOL2 RS17130
gene id: 651182:TOL2_RS17130
uniprot id: K0NMX2
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

651182:TOL2 RS21405
gene id: 651182:TOL2_RS21405
uniprot id: K0NNF9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS11785
gene id: 651182:TOL2_RS11785
uniprot id: K0NNK9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

651182:TOL2 RS13480
gene id: 651182:TOL2_RS13480
uniprot id: K0NHC4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

651182:TOL2 RS00210
gene id: 651182:TOL2_RS00210
uniprot id: K0NC64
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS11865
gene id: 651182:TOL2_RS11865
uniprot id: K0NKB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

651182:TOL2 RS04205
gene id: 651182:TOL2_RS04205
uniprot id: K0NGI6
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS20060
gene id: 651182:TOL2_RS20060
uniprot id: K0NSG3
names: Similarity
messages: Belongs to the peptidase S16 family.

651182:TOL2 RS19260
gene id: 651182:TOL2_RS19260
uniprot id: K0NJU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS23230
gene id: 651182:TOL2_RS23230
uniprot id: K0NU01
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

651182:TOL2 RS17535
gene id: 651182:TOL2_RS17535
uniprot id: K0NR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS04290
gene id: 651182:TOL2_RS04290
uniprot id: K0NDI2
names: Similarity
messages: Belongs to the YoeB family.

651182:TOL2 RS18725
gene id: 651182:TOL2_RS18725
uniprot id: K0NRT2
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

651182:TOL2 RS08845
gene id: 651182:TOL2_RS08845
uniprot id: K0N766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

651182:TOL2 RS16820
gene id: 651182:TOL2_RS16820
uniprot id: K0NAU7
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

651182:TOL2 RS12095
gene id: 651182:TOL2_RS12095
uniprot id: K0NGP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

651182:TOL2 RS10365
gene id: 651182:TOL2_RS10365
uniprot id: K0NG29
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS15890
gene id: 651182:TOL2_RS15890
uniprot id: K0NAM3
names: Similarity
messages: Belongs to the LarC family.

651182:TOL2 RS12105
gene id: 651182:TOL2_RS12105
uniprot id: K0NKF2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS01885
gene id: 651182:TOL2_RS01885
uniprot id: K0NFM5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

651182:TOL2 RS13365
gene id: 651182:TOL2_RS13365
uniprot id: K0NI79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS04330
gene id: 651182:TOL2_RS04330
uniprot id: K0NJ90
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

651182:TOL2 RS20685
gene id: 651182:TOL2_RS20685
uniprot id: K0NKH5
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS23095
gene id: 651182:TOL2_RS23095
uniprot id: K0NP97
names: Similarity
messages: Belongs to the AOR/FOR family.

651182:TOL2 RS03660
gene id: 651182:TOL2_RS03660
uniprot id: K0NDI0
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

651182:TOL2 RS02660
gene id: 651182:TOL2_RS02660
uniprot id: K0NCR9
names: Similarity
names: Subunit
messages: Belongs to the organic radical-activating enzymes family.
messages: Monomer.

651182:TOL2 RS02745
gene id: 651182:TOL2_RS02745
uniprot id: K0NFY0
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18275
gene id: 651182:TOL2_RS18275
uniprot id: K0NBC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS13175
gene id: 651182:TOL2_RS13175
uniprot id: K0NL06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

651182:TOL2 RS00425
gene id: 651182:TOL2_RS00425
uniprot id: K0NGW5
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

651182:TOL2 RS13290
gene id: 651182:TOL2_RS13290
uniprot id: K0NHA7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

651182:TOL2 RS14600
gene id: 651182:TOL2_RS14600
uniprot id: K0NHR3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

651182:TOL2 RS15870
gene id: 651182:TOL2_RS15870
uniprot id: K0NJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

651182:TOL2 RS12835
gene id: 651182:TOL2_RS12835
uniprot id: K0NH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

651182:TOL2 RS23400
gene id: 651182:TOL2_RS23400
uniprot id: K0NIM2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS13160
gene id: 651182:TOL2_RS13160
uniprot id: K0NP91
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

651182:TOL2 RS06070
gene id: 651182:TOL2_RS06070
uniprot id: K0NKK9
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS17210
gene id: 651182:TOL2_RS17210
uniprot id: K0NMY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

651182:TOL2 RS06505
gene id: 651182:TOL2_RS06505
uniprot id: K0N5N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

651182:TOL2 RS16870
gene id: 651182:TOL2_RS16870
uniprot id: K0NAV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

651182:TOL2 RS20365
gene id: 651182:TOL2_RS20365
uniprot id: K0NPC2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS01750
gene id: 651182:TOL2_RS01750
uniprot id: K0NCD6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

651182:TOL2 RS13315
gene id: 651182:TOL2_RS13315
uniprot id: K0NHA9
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

651182:TOL2 RS18955
gene id: 651182:TOL2_RS18955
uniprot id: K0NLV6
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

651182:TOL2 RS03690
gene id: 651182:TOL2_RS03690
uniprot id: K0NDI4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS12810
gene id: 651182:TOL2_RS12810
uniprot id: K0NH53
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS12430
gene id: 651182:TOL2_RS12430
uniprot id: K0NGV7
names: Similarity
messages: Belongs to the CapA family.

651182:TOL2 RS02135
gene id: 651182:TOL2_RS02135
uniprot id: K0NHX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

651182:TOL2 RS18605
gene id: 651182:TOL2_RS18605
uniprot id: K0NBF9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

651182:TOL2 RS14785
gene id: 651182:TOL2_RS14785
uniprot id: K0NLH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

651182:TOL2 RS17995
gene id: 651182:TOL2_RS17995
uniprot id: K0NNE3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

651182:TOL2 RS10690
gene id: 651182:TOL2_RS10690
uniprot id: K0NGS2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS06205
gene id: 651182:TOL2_RS06205
uniprot id: K0NKP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

651182:TOL2 RS15895
gene id: 651182:TOL2_RS15895
uniprot id: K0NJW6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

651182:TOL2 RS19225
gene id: 651182:TOL2_RS19225
uniprot id: K0NBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

651182:TOL2 RS23235
gene id: 651182:TOL2_RS23235
uniprot id: K0NQY8
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

651182:TOL2 RS10405
gene id: 651182:TOL2_RS10405
uniprot id: K0N882
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS20130
gene id: 651182:TOL2_RS20130
uniprot id: K0NK70
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

651182:TOL2 RS09825
gene id: 651182:TOL2_RS09825
uniprot id: K0NFT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

651182:TOL2 RS00350
gene id: 651182:TOL2_RS00350
uniprot id: K0NGV3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

651182:TOL2 RS18220
gene id: 651182:TOL2_RS18220
uniprot id: K0NNJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

651182:TOL2 RS20090
gene id: 651182:TOL2_RS20090
uniprot id: K0NP78
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

651182:TOL2 RS18400
gene id: 651182:TOL2_RS18400
uniprot id: K0NNL7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

651182:TOL2 RS21285
gene id: 651182:TOL2_RS21285
uniprot id: K0NT10
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

651182:TOL2 RS13485
gene id: 651182:TOL2_RS13485
uniprot id: K0NPC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

651182:TOL2 RS12540
gene id: 651182:TOL2_RS12540
uniprot id: K0NKN1
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS03670
gene id: 651182:TOL2_RS03670
uniprot id: K0NIN1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

651182:TOL2 RS16700
gene id: 651182:TOL2_RS16700
uniprot id: K0NIN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

651182:TOL2 RS15085
gene id: 651182:TOL2_RS15085
uniprot id: K0NAB5
names: Similarity
messages: Belongs to the D-alanine--D-alanine ligase family.

651182:TOL2 RS00965
gene id: 651182:TOL2_RS00965
uniprot id: K0N2H0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

651182:TOL2 RS05245
gene id: 651182:TOL2_RS05245
uniprot id: K0NDX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

651182:TOL2 RS11715
gene id: 651182:TOL2_RS11715
uniprot id: K0N8T8
names: Similarity
messages: Belongs to the thioredoxin family.

651182:TOL2 RS17745
gene id: 651182:TOL2_RS17745
uniprot id: K0NB41
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS11835
gene id: 651182:TOL2_RS11835
uniprot id: K0NNL8
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

651182:TOL2 RS17145
gene id: 651182:TOL2_RS17145
uniprot id: K0NIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

651182:TOL2 RS02655
gene id: 651182:TOL2_RS02655
uniprot id: K0ND27
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

651182:TOL2 RS01350
gene id: 651182:TOL2_RS01350
uniprot id: K0NFD7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

651182:TOL2 RS17260
gene id: 651182:TOL2_RS17260
uniprot id: K0NMZ3
names: Similarity
messages: Belongs to the glutamate synthase family.

651182:TOL2 RS17705
gene id: 651182:TOL2_RS17705
uniprot id: K0NJ32
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

651182:TOL2 RS09340
gene id: 651182:TOL2_RS09340
uniprot id: K0NFK7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

651182:TOL2 RS10580
gene id: 651182:TOL2_RS10580
uniprot id: K0NJS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

651182:TOL2 RS22960
gene id: 651182:TOL2_RS22960
uniprot id: K0NTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

651182:TOL2 RS18200
gene id: 651182:TOL2_RS18200
uniprot id: K0NBB7
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS18435
gene id: 651182:TOL2_RS18435
uniprot id: K0NLJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

651182:TOL2 RS19305
gene id: 651182:TOL2_RS19305
uniprot id: K0NBP5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS10640
gene id: 651182:TOL2_RS10640
uniprot id: K0NGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

651182:TOL2 RS11945
gene id: 651182:TOL2_RS11945
uniprot id: K0NKC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

651182:TOL2 RS04940
gene id: 651182:TOL2_RS04940
uniprot id: K0NE46
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS16110
gene id: 651182:TOL2_RS16110
uniprot id: K0NJZ8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

651182:TOL2 RS18005
gene id: 651182:TOL2_RS18005
uniprot id: K0NLC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

651182:TOL2 RS11790
gene id: 651182:TOL2_RS11790
uniprot id: K0NK97
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

651182:TOL2 RS08700
gene id: 651182:TOL2_RS08700
uniprot id: K0NF87
names: Similarity
messages: Belongs to the RemA family.

651182:TOL2 RS00050
gene id: 651182:TOL2_RS00050
uniprot id: K0NC49
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

651182:TOL2 RS05190
gene id: 651182:TOL2_RS05190
uniprot id: K0NE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

651182:TOL2 RS00825
gene id: 651182:TOL2_RS00825
uniprot id: K0NH30
names: Similarity
names: Subunit
messages: Belongs to the organic radical-activating enzymes family.
messages: Monomer.

651182:TOL2 RS02155
gene id: 651182:TOL2_RS02155
uniprot id: K0NCL8
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS16585
gene id: 651182:TOL2_RS16585
uniprot id: K0NAS5
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

651182:TOL2 RS13660
gene id: 651182:TOL2_RS13660
uniprot id: K0NHE6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

651182:TOL2 RS21580
gene id: 651182:TOL2_RS21580
uniprot id: K0NCI8
names: Similarity
messages: Belongs to the hemerythrin family.

651182:TOL2 RS06525
gene id: 651182:TOL2_RS06525
uniprot id: K0NHQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS06625
gene id: 651182:TOL2_RS06625
uniprot id: K0NHT1
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

651182:TOL2 RS07830
gene id: 651182:TOL2_RS07830
uniprot id: K0NEU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

651182:TOL2 RS04045
gene id: 651182:TOL2_RS04045
uniprot id: K0N475
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

651182:TOL2 RS01625
gene id: 651182:TOL2_RS01625
uniprot id: K0NCB7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS21430
gene id: 651182:TOL2_RS21430
uniprot id: K0NNG2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

651182:TOL2 RS07040
gene id: 651182:TOL2_RS07040
uniprot id: K0N612
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

651182:TOL2 RS14590
gene id: 651182:TOL2_RS14590
uniprot id: K0NA17
names: Similarity
messages: Belongs to the universal stress protein A family.

651182:TOL2 RS11655
gene id: 651182:TOL2_RS11655
uniprot id: K0NNI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

651182:TOL2 RS12790
gene id: 651182:TOL2_RS12790
uniprot id: K0NP56
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS00105
gene id: 651182:TOL2_RS00105
uniprot id: K0NEZ6
names: Similarity
messages: Belongs to the HsdR family.

651182:TOL2 RS15545
gene id: 651182:TOL2_RS15545
uniprot id: K0NJQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

651182:TOL2 RS21840
gene id: 651182:TOL2_RS21840
uniprot id: K0NL10
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

651182:TOL2 RS03265
gene id: 651182:TOL2_RS03265
uniprot id: K0NIF3
names: Similarity
messages: Belongs to the histone deacetylase family.

651182:TOL2 RS15160
gene id: 651182:TOL2_RS15160
uniprot id: K0NAD4
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

651182:TOL2 RS23055
gene id: 651182:TOL2_RS23055
uniprot id: K0NTV5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

651182:TOL2 RS13795
gene id: 651182:TOL2_RS13795
uniprot id: K0NL76
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS08840
gene id: 651182:TOL2_RS08840
uniprot id: K0NIY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

651182:TOL2 RS06690
gene id: 651182:TOL2_RS06690
uniprot id: K0NL01
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS01985
gene id: 651182:TOL2_RS01985
uniprot id: K0NHS9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS07905
gene id: 651182:TOL2_RS07905
uniprot id: K0NFE5
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS14460
gene id: 651182:TOL2_RS14460
uniprot id: K0NHQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

651182:TOL2 RS13150
gene id: 651182:TOL2_RS13150
uniprot id: K0NI48
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

651182:TOL2 RS05760
gene id: 651182:TOL2_RS05760
uniprot id: K0NEB9
names: Similarity
messages: Belongs to the group II decarboxylase family.

651182:TOL2 RS16980
gene id: 651182:TOL2_RS16980
uniprot id: K0NIT6
names: Similarity
messages: Belongs to the YjdM family.

651182:TOL2 RS20660
gene id: 651182:TOL2_RS20660
uniprot id: K0NKG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

651182:TOL2 RS05455
gene id: 651182:TOL2_RS05455
uniprot id: K0N4X5
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

651182:TOL2 RS15035
gene id: 651182:TOL2_RS15035
uniprot id: K0NAA6
names: Subcellular Location Annotation
messages: Cell inner membrane

651182:TOL2 RS02190
gene id: 651182:TOL2_RS02190
uniprot id: K0NFS7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

651182:TOL2 RS17870
gene id: 651182:TOL2_RS17870
uniprot id: K0NNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

651182:TOL2 RS13440
gene id: 651182:TOL2_RS13440
uniprot id: K0NL38
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

651182:TOL2 RS18550
gene id: 651182:TOL2_RS18550
uniprot id: K0NBF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

651182:TOL2 RS06540
gene id: 651182:TOL2_RS06540
uniprot id: K0NEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS05285
gene id: 651182:TOL2_RS05285
uniprot id: K0NH09
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

651182:TOL2 RS01575
gene id: 651182:TOL2_RS01575
uniprot id: K0NCA9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

651182:TOL2 RS08810
gene id: 651182:TOL2_RS08810
uniprot id: K0NM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

651182:TOL2 RS13475
gene id: 651182:TOL2_RS13475
uniprot id: K0NI94
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

651182:TOL2 RS10450
gene id: 651182:TOL2_RS10450
uniprot id: K0NJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

651182:TOL2 RS22720
gene id: 651182:TOL2_RS22720
uniprot id: K0NLJ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

651182:TOL2 RS17640
gene id: 651182:TOL2_RS17640
uniprot id: K0NN72
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

651182:TOL2 RS03315
gene id: 651182:TOL2_RS03315
uniprot id: K0NIG2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

651182:TOL2 RS09785
gene id: 651182:TOL2_RS09785
uniprot id: K0NJD5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

651182:TOL2 RS07205
gene id: 651182:TOL2_RS07205
uniprot id: K0NEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

651182:TOL2 RS21045
gene id: 651182:TOL2_RS21045
uniprot id: K0NSY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

651182:TOL2 RS07580
gene id: 651182:TOL2_RS07580
uniprot id: K0NLQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

651182:TOL2 RS21585
gene id: 651182:TOL2_RS21585
uniprot id: K0NNI1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

651182:TOL2 RS01970
gene id: 651182:TOL2_RS01970
uniprot id: K0N339
names: Subcellular Location Annotation
messages: Membrane

651182:TOL2 RS11795
gene id: 651182:TOL2_RS11795
uniprot id: K0N8V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

651182:TOL2 RS11315
gene id: 651182:TOL2_RS11315
uniprot id: K0NND5
names: Similarity
messages: Belongs to the pyruvate kinase family.

651182:TOL2 RS23285
gene id: 651182:TOL2_RS23285
uniprot id: K0NCG2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

651182:TOL2 RS10720
gene id: 651182:TOL2_RS10720
uniprot id: K0NG66
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

651182:TOL2 RS23570
gene id: 651182:TOL2_RS23570
uniprot id: K0N6V6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

651182:TOL2 RS01180
gene id: 651182:TOL2_RS01180
uniprot id: K0NFA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

651182:TOL2 RS19055
gene id: 651182:TOL2_RS19055
uniprot id: K0NLX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.