647113:METOK RS03345
gene id: 647113:METOK_RS03345
uniprot id: F8ALS9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

647113:METOK RS04995
gene id: 647113:METOK_RS04995
uniprot id: F8AN34
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

647113:METOK RS01020
gene id: 647113:METOK_RS01020
uniprot id: F8ANE1
names: Similarity
messages: Belongs to the UPF0285 family.

647113:METOK RS04570
gene id: 647113:METOK_RS04570
uniprot id: F8AMN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

647113:METOK RS02075
gene id: 647113:METOK_RS02075
uniprot id: F8AKR1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

647113:METOK RS00105
gene id: 647113:METOK_RS00105
uniprot id: F8AMH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

647113:METOK RS02420
gene id: 647113:METOK_RS02420
uniprot id: F8AL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS02730
gene id: 647113:METOK_RS02730
uniprot id: F8ALD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

647113:METOK RS04080
gene id: 647113:METOK_RS04080
uniprot id: F8AM89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

647113:METOK RS03470
gene id: 647113:METOK_RS03470
uniprot id: F8ALY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

647113:METOK RS00595
gene id: 647113:METOK_RS00595
uniprot id: F8AMZ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS02255
gene id: 647113:METOK_RS02255
uniprot id: F8AL01
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS00420
gene id: 647113:METOK_RS00420
uniprot id: F8AMW0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

647113:METOK RS00820
gene id: 647113:METOK_RS00820
uniprot id: F8ANA1
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

647113:METOK RS04170
gene id: 647113:METOK_RS04170
uniprot id: F8AM99
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

647113:METOK RS04895
gene id: 647113:METOK_RS04895
uniprot id: F8AMU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

647113:METOK RS04355
gene id: 647113:METOK_RS04355
uniprot id: F8AMD2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS02585
gene id: 647113:METOK_RS02585
uniprot id: F8ALB2
names: Similarity
messages: Belongs to the DMRL synthase family.

647113:METOK RS07305
gene id: 647113:METOK_RS07305
uniprot id: F8AK34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

647113:METOK RS00535
gene id: 647113:METOK_RS00535
uniprot id: F8AMY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

647113:METOK RS03115
gene id: 647113:METOK_RS03115
uniprot id: F8ALP4
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS02630
gene id: 647113:METOK_RS02630
uniprot id: F8ALC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

647113:METOK RS04915
gene id: 647113:METOK_RS04915
uniprot id: F8AMU6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS01680
gene id: 647113:METOK_RS01680
uniprot id: F8AKD0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

647113:METOK RS04725
gene id: 647113:METOK_RS04725
uniprot id: F8AMR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.

647113:METOK RS01385
gene id: 647113:METOK_RS01385
uniprot id: F8ANS4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

647113:METOK RS00080
gene id: 647113:METOK_RS00080
uniprot id: F8AMH3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

647113:METOK RS02230
gene id: 647113:METOK_RS02230
uniprot id: F8AKZ7
names: Similarity
messages: Belongs to the UPF0235 family.

647113:METOK RS03370
gene id: 647113:METOK_RS03370
uniprot id: F8ALW9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS03030
gene id: 647113:METOK_RS03030
uniprot id: F8ALM7
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

647113:METOK RS01080
gene id: 647113:METOK_RS01080
uniprot id: F8ANE9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

647113:METOK RS06780
gene id: 647113:METOK_RS06780
uniprot id: F8AJU6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

647113:METOK RS01665
gene id: 647113:METOK_RS01665
uniprot id: F8AKC7
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03020
gene id: 647113:METOK_RS03020
uniprot id: F8ALM5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

647113:METOK RS07725
gene id: 647113:METOK_RS07725
uniprot id: F8AKF8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

647113:METOK RS03325
gene id: 647113:METOK_RS03325
uniprot id: F8AL83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

647113:METOK RS03095
gene id: 647113:METOK_RS03095
uniprot id: F8ALP0
names: Similarity
messages: Belongs to the glutamate synthase family.

647113:METOK RS05430
gene id: 647113:METOK_RS05430
uniprot id: F8ANH8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

647113:METOK RS02775
gene id: 647113:METOK_RS02775
uniprot id: F8ALE8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

647113:METOK RS04990
gene id: 647113:METOK_RS04990
uniprot id: F8AN33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

647113:METOK RS00445
gene id: 647113:METOK_RS00445
uniprot id: F8AMW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

647113:METOK RS05725
gene id: 647113:METOK_RS05725
uniprot id: F8ANU8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-108 inactivates the nitrogenase reductase and regulates nitrogenase activity.

647113:METOK RS07595
gene id: 647113:METOK_RS07595
uniprot id: F8AK86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

647113:METOK RS00965
gene id: 647113:METOK_RS00965
uniprot id: F8AND0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

647113:METOK RS03970
gene id: 647113:METOK_RS03970
uniprot id: F8AM69
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

647113:METOK RS02870
gene id: 647113:METOK_RS02870
uniprot id: F8ALG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

647113:METOK RS03055
gene id: 647113:METOK_RS03055
uniprot id: F8ALN2
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS07885
gene id: 647113:METOK_RS07885
uniprot id: F8ALV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

647113:METOK RS00215
gene id: 647113:METOK_RS00215
uniprot id: F8AMK0
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS02580
gene id: 647113:METOK_RS02580
uniprot id: F8ALB1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

647113:METOK RS05600
gene id: 647113:METOK_RS05600
uniprot id: F8ALI4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

647113:METOK RS04195
gene id: 647113:METOK_RS04195
uniprot id: F8AMA4
names: Similarity
messages: Belongs to the HisA/HisF family.

647113:METOK RS01040
gene id: 647113:METOK_RS01040
uniprot id: F8AKW9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

647113:METOK RS02100
gene id: 647113:METOK_RS02100
uniprot id: F8AKY8
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

647113:METOK RS02240
gene id: 647113:METOK_RS02240
uniprot id: F8AKZ9
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS01255
gene id: 647113:METOK_RS01255
uniprot id: F8ANP9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

647113:METOK RS00385
gene id: 647113:METOK_RS00385
uniprot id: F8AMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

647113:METOK RS01120
gene id: 647113:METOK_RS01120
uniprot id: F8ANF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

647113:METOK RS07225
gene id: 647113:METOK_RS07225
uniprot id: F8AK24
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

647113:METOK RS02105
gene id: 647113:METOK_RS02105
uniprot id: F8AKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

647113:METOK RS06535
gene id: 647113:METOK_RS06535
uniprot id: F8AJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

647113:METOK RS04595
gene id: 647113:METOK_RS04595
uniprot id: F8AMP0
names: Similarity
messages: Belongs to the FrhG family.

647113:METOK RS07640
gene id: 647113:METOK_RS07640
uniprot id: F8AK94
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

647113:METOK RS02130
gene id: 647113:METOK_RS02130
uniprot id: F8AKS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

647113:METOK RS06355
gene id: 647113:METOK_RS06355
uniprot id: F8AJM4
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

647113:METOK RS07985
gene id: 647113:METOK_RS07985
uniprot id: F8AKK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

647113:METOK RS07775
gene id: 647113:METOK_RS07775
uniprot id: F8AKG8
names: Similarity
messages: Belongs to the glutaredoxin family.

647113:METOK RS05510
gene id: 647113:METOK_RS05510
uniprot id: F8ANJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

647113:METOK RS05570
gene id: 647113:METOK_RS05570
uniprot id: F8ANK6
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06515
gene id: 647113:METOK_RS06515
uniprot id: F8AJP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

647113:METOK RS03840
gene id: 647113:METOK_RS03840
uniprot id: F8AM45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

647113:METOK RS03625
gene id: 647113:METOK_RS03625
uniprot id: F8AM13
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

647113:METOK RS06795
gene id: 647113:METOK_RS06795
uniprot id: F8AJU9
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

647113:METOK RS02165
gene id: 647113:METOK_RS02165
uniprot id: F8AKS7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

647113:METOK RS05880
gene id: 647113:METOK_RS05880
uniprot id: F8ANX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

647113:METOK RS06415
gene id: 647113:METOK_RS06415
uniprot id: F8AJN3
names: Similarity
messages: Belongs to the UPF0248 family.

647113:METOK RS06615
gene id: 647113:METOK_RS06615
uniprot id: F8AJR8
names: Similarity
messages: Belongs to the archaeal ATPase family.

647113:METOK RS05580
gene id: 647113:METOK_RS05580
uniprot id: F8ALI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

647113:METOK RS00525
gene id: 647113:METOK_RS00525
uniprot id: F8AMY0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

647113:METOK RS03155
gene id: 647113:METOK_RS03155
uniprot id: F8ALQ3
names: Similarity
messages: Belongs to the hemerythrin family.

647113:METOK RS08090
gene id: 647113:METOK_RS08090
uniprot id: F8AKT6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

647113:METOK RS07175
gene id: 647113:METOK_RS07175
uniprot id: F8ALU0
names: Similarity
messages: Belongs to the UPF0254 family.

647113:METOK RS01335
gene id: 647113:METOK_RS01335
uniprot id: F8ANR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS04505
gene id: 647113:METOK_RS04505
uniprot id: F8AMF4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

647113:METOK RS07805
gene id: 647113:METOK_RS07805
uniprot id: F8AKH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

647113:METOK RS00065
gene id: 647113:METOK_RS00065
uniprot id: F8AMH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

647113:METOK RS07005
gene id: 647113:METOK_RS07005
uniprot id: F8AJY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

647113:METOK RS07105
gene id: 647113:METOK_RS07105
uniprot id: F8ALT7
names: Similarity
messages: Belongs to the UPF0292 family.

647113:METOK RS01645
gene id: 647113:METOK_RS01645
uniprot id: F8AKC4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

647113:METOK RS03365
gene id: 647113:METOK_RS03365
uniprot id: F8ALW8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

647113:METOK RS02725
gene id: 647113:METOK_RS02725
uniprot id: F8ALD8
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

647113:METOK RS01670
gene id: 647113:METOK_RS01670
uniprot id: F8AKC8
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS04175
gene id: 647113:METOK_RS04175
uniprot id: F8AMA0
names: Similarity
messages: Belongs to the archaeal ATPase family.

647113:METOK RS04740
gene id: 647113:METOK_RS04740
uniprot id: F8AMR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

647113:METOK RS01085
gene id: 647113:METOK_RS01085
uniprot id: F8ANF0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

647113:METOK RS06725
gene id: 647113:METOK_RS06725
uniprot id: F8AJT8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

647113:METOK RS02080
gene id: 647113:METOK_RS02080
uniprot id: F8AKR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

647113:METOK RS05625
gene id: 647113:METOK_RS05625
uniprot id: F8ANL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

647113:METOK RS06560
gene id: 647113:METOK_RS06560
uniprot id: F8AJQ7
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

647113:METOK RS05250
gene id: 647113:METOK_RS05250
uniprot id: F8AN79
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

647113:METOK RS04295
gene id: 647113:METOK_RS04295
uniprot id: F8AMC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

647113:METOK RS06440
gene id: 647113:METOK_RS06440
uniprot id: F8AJN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

647113:METOK RS02505
gene id: 647113:METOK_RS02505
uniprot id: F8AL49
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

647113:METOK RS02720
gene id: 647113:METOK_RS02720
uniprot id: F8ALD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

647113:METOK RS01740
gene id: 647113:METOK_RS01740
uniprot id: F8AKE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

647113:METOK RS00465
gene id: 647113:METOK_RS00465
uniprot id: F8AMW8
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS01620
gene id: 647113:METOK_RS01620
uniprot id: F8AKB9
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS01065
gene id: 647113:METOK_RS01065
uniprot id: F8AKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

647113:METOK RS01960
gene id: 647113:METOK_RS01960
uniprot id: F8AKP4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS00125
gene id: 647113:METOK_RS00125
uniprot id: F8AMI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

647113:METOK RS01350
gene id: 647113:METOK_RS01350
uniprot id: F8ANR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

647113:METOK RS05095
gene id: 647113:METOK_RS05095
uniprot id: F8AN54
names: Similarity
messages: Belongs to the HupF/HypC family.

647113:METOK RS01660
gene id: 647113:METOK_RS01660
uniprot id: F8AKC6
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06260
gene id: 647113:METOK_RS06260
uniprot id: F8AJK8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

647113:METOK RS06755
gene id: 647113:METOK_RS06755
uniprot id: F8AJU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

647113:METOK RS00400
gene id: 647113:METOK_RS00400
uniprot id: F8AMV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

647113:METOK RS03750
gene id: 647113:METOK_RS03750
uniprot id: F8AL94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

647113:METOK RS04350
gene id: 647113:METOK_RS04350
uniprot id: F8AMD1
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS05950
gene id: 647113:METOK_RS05950
uniprot id: F8ANZ0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

647113:METOK RS06625
gene id: 647113:METOK_RS06625
uniprot id: F8AJS0
names: Similarity
messages: Belongs to the archaeal ATPase family.

647113:METOK RS02865
gene id: 647113:METOK_RS02865
uniprot id: F8ALG1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS05125
gene id: 647113:METOK_RS05125
uniprot id: F8ALH6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

647113:METOK RS06380
gene id: 647113:METOK_RS06380
uniprot id: F8AJM9
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS00190
gene id: 647113:METOK_RS00190
uniprot id: F8AMJ5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

647113:METOK RS07285
gene id: 647113:METOK_RS07285
uniprot id: F8ALU5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

647113:METOK RS04745
gene id: 647113:METOK_RS04745
uniprot id: F8AMS0
names: Similarity
messages: Belongs to the UPF0045 family.

647113:METOK RS08020
gene id: 647113:METOK_RS08020
uniprot id: F8AKK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS05505
gene id: 647113:METOK_RS05505
uniprot id: F8ANJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

647113:METOK RS07570
gene id: 647113:METOK_RS07570
uniprot id: F8AK82
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

647113:METOK RS06585
gene id: 647113:METOK_RS06585
uniprot id: F8AJR2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS05145
gene id: 647113:METOK_RS05145
uniprot id: F8AN61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS01655
gene id: 647113:METOK_RS01655
uniprot id: F8AKC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

647113:METOK RS06400
gene id: 647113:METOK_RS06400
uniprot id: F8ALK4
names: Similarity
messages: Belongs to the HypD family.

647113:METOK RS01440
gene id: 647113:METOK_RS01440
uniprot id: F8AKX9
names: Similarity
messages: Belongs to the MCM family.

647113:METOK RS03555
gene id: 647113:METOK_RS03555
uniprot id: F8AM04
names: Similarity
messages: Belongs to the AAA ATPase family.

647113:METOK RS06855
gene id: 647113:METOK_RS06855
uniprot id: F8AJV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

647113:METOK RS07810
gene id: 647113:METOK_RS07810
uniprot id: F8AKH5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS03385
gene id: 647113:METOK_RS03385
uniprot id: F8ALX2
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS00550
gene id: 647113:METOK_RS00550
uniprot id: F8AMY5
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

647113:METOK RS01300
gene id: 647113:METOK_RS01300
uniprot id: F8ANQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

647113:METOK RS06850
gene id: 647113:METOK_RS06850
uniprot id: F8ALT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

647113:METOK RS07350
gene id: 647113:METOK_RS07350
uniprot id: F8AK42
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

647113:METOK RS05990
gene id: 647113:METOK_RS05990
uniprot id: F8ALJ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

647113:METOK RS03595
gene id: 647113:METOK_RS03595
uniprot id: F8AM08
names: Similarity
messages: Belongs to the MCM family.

647113:METOK RS00900
gene id: 647113:METOK_RS00900
uniprot id: F8ANB7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

647113:METOK RS05590
gene id: 647113:METOK_RS05590
uniprot id: F8ANK9
names: Similarity
messages: Belongs to the UPF0212 family.

647113:METOK RS05150
gene id: 647113:METOK_RS05150
uniprot id: F8AN62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

647113:METOK RS05195
gene id: 647113:METOK_RS05195
uniprot id: F8AN70
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

647113:METOK RS00555
gene id: 647113:METOK_RS00555
uniprot id: F8AMY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

647113:METOK RS03425
gene id: 647113:METOK_RS03425
uniprot id: F8ALY0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS05975
gene id: 647113:METOK_RS05975
uniprot id: F8ANZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS00015
gene id: 647113:METOK_RS00015
uniprot id: F8AMG1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

647113:METOK RS07240
gene id: 647113:METOK_RS07240
uniprot id: F8ALU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

647113:METOK RS05080
gene id: 647113:METOK_RS05080
uniprot id: F8AN51
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS04845
gene id: 647113:METOK_RS04845
uniprot id: F8AMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS01135
gene id: 647113:METOK_RS01135
uniprot id: F8ANM6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

647113:METOK RS00115
gene id: 647113:METOK_RS00115
uniprot id: F8AMI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

647113:METOK RS04040
gene id: 647113:METOK_RS04040
uniprot id: F8AL97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

647113:METOK RS00915
gene id: 647113:METOK_RS00915
uniprot id: F8ANC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

647113:METOK RS04375
gene id: 647113:METOK_RS04375
uniprot id: F8AMD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

647113:METOK RS03635
gene id: 647113:METOK_RS03635
uniprot id: F8AM14
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS01250
gene id: 647113:METOK_RS01250
uniprot id: F8ANP8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

647113:METOK RS04850
gene id: 647113:METOK_RS04850
uniprot id: F8ALH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS06555
gene id: 647113:METOK_RS06555
uniprot id: F8AJQ6
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

647113:METOK RS07500
gene id: 647113:METOK_RS07500
uniprot id: F8AK68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

647113:METOK RS07605
gene id: 647113:METOK_RS07605
uniprot id: F8AK87
names: Similarity
messages: Belongs to the DtxR/MntR family.

647113:METOK RS00175
gene id: 647113:METOK_RS00175
uniprot id: F8AMJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

647113:METOK RS04030
gene id: 647113:METOK_RS04030
uniprot id: F8AM80
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS07540
gene id: 647113:METOK_RS07540
uniprot id: F8AK76
names: Similarity
messages: Belongs to the UPF0166 family.

647113:METOK RS03220
gene id: 647113:METOK_RS03220
uniprot id: F8ALR0
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

647113:METOK RS03680
gene id: 647113:METOK_RS03680
uniprot id: F8AM21
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06915
gene id: 647113:METOK_RS06915
uniprot id: F8AJW7
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS01275
gene id: 647113:METOK_RS01275
uniprot id: F8ANQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

647113:METOK RS07125
gene id: 647113:METOK_RS07125
uniprot id: F8ALT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS08065
gene id: 647113:METOK_RS08065
uniprot id: F8AKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

647113:METOK RS01315
gene id: 647113:METOK_RS01315
uniprot id: F8ANR1
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

647113:METOK RS06565
gene id: 647113:METOK_RS06565
uniprot id: F8AJQ8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

647113:METOK RS00750
gene id: 647113:METOK_RS00750
uniprot id: F8AN20
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS00810
gene id: 647113:METOK_RS00810
uniprot id: F8ANA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

647113:METOK RS00450
gene id: 647113:METOK_RS00450
uniprot id: F8AMW5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

647113:METOK RS00100
gene id: 647113:METOK_RS00100
uniprot id: F8AMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS05270
gene id: 647113:METOK_RS05270
uniprot id: F8AN81
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS04555
gene id: 647113:METOK_RS04555
uniprot id: F8AMN2
names: Similarity
messages: Belongs to the NodU/CmcH family.

647113:METOK RS07620
gene id: 647113:METOK_RS07620
uniprot id: F8AK90
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06235
gene id: 647113:METOK_RS06235
uniprot id: F8AJK4
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

647113:METOK RS05045
gene id: 647113:METOK_RS05045
uniprot id: F8AN44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

647113:METOK RS01355
gene id: 647113:METOK_RS01355
uniprot id: F8ANS0
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

647113:METOK RS05670
gene id: 647113:METOK_RS05670
uniprot id: F8ANM1
names: Similarity
messages: Belongs to the UPF0237 family.

647113:METOK RS03715
gene id: 647113:METOK_RS03715
uniprot id: F8AL92
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

647113:METOK RS07365
gene id: 647113:METOK_RS07365
uniprot id: F8AK44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

647113:METOK RS06005
gene id: 647113:METOK_RS06005
uniprot id: F8AP00
names: Similarity
messages: Belongs to the FwdC/FmdC family.

647113:METOK RS06520
gene id: 647113:METOK_RS06520
uniprot id: F8AJP9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

647113:METOK RS00305
gene id: 647113:METOK_RS00305
uniprot id: F8AML8
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

647113:METOK RS00030
gene id: 647113:METOK_RS00030
uniprot id: F8AMG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

647113:METOK RS03735
gene id: 647113:METOK_RS03735
uniprot id: F8AM27
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

647113:METOK RS06135
gene id: 647113:METOK_RS06135
uniprot id: F8AJI4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

647113:METOK RS05620
gene id: 647113:METOK_RS05620
uniprot id: F8ANL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

647113:METOK RS03320
gene id: 647113:METOK_RS03320
uniprot id: F8ALS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

647113:METOK RS04010
gene id: 647113:METOK_RS04010
uniprot id: F8AL96
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

647113:METOK RS02905
gene id: 647113:METOK_RS02905
uniprot id: F8ALG6
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

647113:METOK RS07695
gene id: 647113:METOK_RS07695
uniprot id: F8AKF2
names: Similarity
messages: Belongs to the MCM family.

647113:METOK RS04390
gene id: 647113:METOK_RS04390
uniprot id: F8AMD8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

647113:METOK RS02370
gene id: 647113:METOK_RS02370
uniprot id: F8AL24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS04515
gene id: 647113:METOK_RS04515
uniprot id: F8AMF5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

647113:METOK RS07790
gene id: 647113:METOK_RS07790
uniprot id: F8AKH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

647113:METOK RS00340
gene id: 647113:METOK_RS00340
uniprot id: F8AMM7
names: Similarity
messages: Belongs to the MoaB/Mog family.

647113:METOK RS04020
gene id: 647113:METOK_RS04020
uniprot id: F8AM78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS06885
gene id: 647113:METOK_RS06885
uniprot id: F8AJW1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

647113:METOK RS00885
gene id: 647113:METOK_RS00885
uniprot id: F8ANB4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

647113:METOK RS03355
gene id: 647113:METOK_RS03355
uniprot id: F8AL84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

647113:METOK RS06275
gene id: 647113:METOK_RS06275
uniprot id: F8AJL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

647113:METOK RS06040
gene id: 647113:METOK_RS06040
uniprot id: F8ALJ5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

647113:METOK RS02390
gene id: 647113:METOK_RS02390
uniprot id: F8AL28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

647113:METOK RS06765
gene id: 647113:METOK_RS06765
uniprot id: F8AJU4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

647113:METOK RS07385
gene id: 647113:METOK_RS07385
uniprot id: F8AK48
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS01110
gene id: 647113:METOK_RS01110
uniprot id: F8AKX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

647113:METOK RS00620
gene id: 647113:METOK_RS00620
uniprot id: F8AMZ9
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

647113:METOK RS06680
gene id: 647113:METOK_RS06680
uniprot id: F8AJT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS04075
gene id: 647113:METOK_RS04075
uniprot id: F8AM88
names: Similarity
messages: Belongs to the SAICAR synthetase family.

647113:METOK RS07890
gene id: 647113:METOK_RS07890
uniprot id: F8ALV9
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS00775
gene id: 647113:METOK_RS00775
uniprot id: F8AN92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

647113:METOK RS03465
gene id: 647113:METOK_RS03465
uniprot id: F8ALY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

647113:METOK RS01140
gene id: 647113:METOK_RS01140
uniprot id: F8ANM7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS01105
gene id: 647113:METOK_RS01105
uniprot id: F8ANF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

647113:METOK RS01150
gene id: 647113:METOK_RS01150
uniprot id: F8ANM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

647113:METOK RS01955
gene id: 647113:METOK_RS01955
uniprot id: F8AKP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

647113:METOK RS01095
gene id: 647113:METOK_RS01095
uniprot id: F8ANF1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

647113:METOK RS01330
gene id: 647113:METOK_RS01330
uniprot id: F8ANR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS01775
gene id: 647113:METOK_RS01775
uniprot id: F8AKE5
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS05530
gene id: 647113:METOK_RS05530
uniprot id: F8ANJ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS01115
gene id: 647113:METOK_RS01115
uniprot id: F8ANF3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

647113:METOK RS02975
gene id: 647113:METOK_RS02975
uniprot id: F8ALG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

647113:METOK RS04860
gene id: 647113:METOK_RS04860
uniprot id: F8ALH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS02615
gene id: 647113:METOK_RS02615
uniprot id: F8ALB8
names: Similarity
messages: Belongs to the class-I fumarase family.

647113:METOK RS06690
gene id: 647113:METOK_RS06690
uniprot id: F8AJT3
names: Similarity
messages: Belongs to the archaeal ATPase family.

647113:METOK RS04940
gene id: 647113:METOK_RS04940
uniprot id: F8AN23
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

647113:METOK RS05545
gene id: 647113:METOK_RS05545
uniprot id: F8ANK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

647113:METOK RS02715
gene id: 647113:METOK_RS02715
uniprot id: F8ALD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

647113:METOK RS07015
gene id: 647113:METOK_RS07015
uniprot id: F8AJY7
names: Similarity
messages: Belongs to the HsdR family.

647113:METOK RS07215
gene id: 647113:METOK_RS07215
uniprot id: F8AK22
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

647113:METOK RS01340
gene id: 647113:METOK_RS01340
uniprot id: F8ANR7
names: Function
messages: Probably involved in the biogenesis of the ribosome.

647113:METOK RS01995
gene id: 647113:METOK_RS01995
uniprot id: F8AKQ1
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03265
gene id: 647113:METOK_RS03265
uniprot id: F8ALR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS04155
gene id: 647113:METOK_RS04155
uniprot id: F8AM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

647113:METOK RS05205
gene id: 647113:METOK_RS05205
uniprot id: F8AN72
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

647113:METOK RS02980
gene id: 647113:METOK_RS02980
uniprot id: F8ALL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

647113:METOK RS07400
gene id: 647113:METOK_RS07400
uniprot id: F8AK51
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

647113:METOK RS07425
gene id: 647113:METOK_RS07425
uniprot id: F8AK55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

647113:METOK RS07680
gene id: 647113:METOK_RS07680
uniprot id: F8AKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

647113:METOK RS05830
gene id: 647113:METOK_RS05830
uniprot id: F8ANW9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

647113:METOK RS03975
gene id: 647113:METOK_RS03975
uniprot id: F8AM70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

647113:METOK RS04955
gene id: 647113:METOK_RS04955
uniprot id: F8AN26
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

647113:METOK RS01715
gene id: 647113:METOK_RS01715
uniprot id: F8AKD5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

647113:METOK RS06475
gene id: 647113:METOK_RS06475
uniprot id: F8ALL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

647113:METOK RS06590
gene id: 647113:METOK_RS06590
uniprot id: F8AJR3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

647113:METOK RS03990
gene id: 647113:METOK_RS03990
uniprot id: F8AM73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

647113:METOK RS05325
gene id: 647113:METOK_RS05325
uniprot id: F8ANF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

647113:METOK RS02525
gene id: 647113:METOK_RS02525
uniprot id: F8AL64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

647113:METOK RS05915
gene id: 647113:METOK_RS05915
uniprot id: F8ANY6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

647113:METOK RS06480
gene id: 647113:METOK_RS06480
uniprot id: F8AJP3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS04835
gene id: 647113:METOK_RS04835
uniprot id: F8AMT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS00060
gene id: 647113:METOK_RS00060
uniprot id: F8AMG9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

647113:METOK RS07420
gene id: 647113:METOK_RS07420
uniprot id: F8AK54
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

647113:METOK RS05130
gene id: 647113:METOK_RS05130
uniprot id: F8AN59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

647113:METOK RS04720
gene id: 647113:METOK_RS04720
uniprot id: F8AMR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

647113:METOK RS06955
gene id: 647113:METOK_RS06955
uniprot id: F8AJX5
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

647113:METOK RS07445
gene id: 647113:METOK_RS07445
uniprot id: F8AK59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

647113:METOK RS01270
gene id: 647113:METOK_RS01270
uniprot id: F8ANQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

647113:METOK RS08115
gene id: 647113:METOK_RS08115
uniprot id: F8AKU1
names: Similarity
messages: Belongs to the glutaredoxin family.

647113:METOK RS02430
gene id: 647113:METOK_RS02430
uniprot id: F8AL36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS00430
gene id: 647113:METOK_RS00430
uniprot id: F8AMW1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

647113:METOK RS01055
gene id: 647113:METOK_RS01055
uniprot id: F8AKX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

647113:METOK RS00785
gene id: 647113:METOK_RS00785
uniprot id: F8AN94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

647113:METOK RS05995
gene id: 647113:METOK_RS05995
uniprot id: F8ANZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

647113:METOK RS06740
gene id: 647113:METOK_RS06740
uniprot id: F8AJU0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

647113:METOK RS04870
gene id: 647113:METOK_RS04870
uniprot id: F8ALH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS03460
gene id: 647113:METOK_RS03460
uniprot id: F8ALY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

647113:METOK RS07845
gene id: 647113:METOK_RS07845
uniprot id: F8AKI2
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

647113:METOK RS02425
gene id: 647113:METOK_RS02425
uniprot id: F8AL35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

647113:METOK RS00290
gene id: 647113:METOK_RS00290
uniprot id: F8AML5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

647113:METOK RS05615
gene id: 647113:METOK_RS05615
uniprot id: F8ANL2
names: Similarity
messages: Belongs to the PstS family.

647113:METOK RS00085
gene id: 647113:METOK_RS00085
uniprot id: F8AMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

647113:METOK RS05585
gene id: 647113:METOK_RS05585
uniprot id: F8ANK8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

647113:METOK RS00985
gene id: 647113:METOK_RS00985
uniprot id: F8AKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

647113:METOK RS01175
gene id: 647113:METOK_RS01175
uniprot id: F8ANN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

647113:METOK RS07040
gene id: 647113:METOK_RS07040
uniprot id: F8AJZ2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

647113:METOK RS05435
gene id: 647113:METOK_RS05435
uniprot id: F8ANH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

647113:METOK RS05695
gene id: 647113:METOK_RS05695
uniprot id: F8ALI8
names: Function
names: Subunit
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

647113:METOK RS03255
gene id: 647113:METOK_RS03255
uniprot id: F8AL80
names: Similarity
messages: Belongs to the UPF0288 family.

647113:METOK RS01325
gene id: 647113:METOK_RS01325
uniprot id: F8ANR4
names: Similarity
messages: Belongs to the SDO1/SBDS family.

647113:METOK RS05845
gene id: 647113:METOK_RS05845
uniprot id: F8ANX2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

647113:METOK RS00090
gene id: 647113:METOK_RS00090
uniprot id: F8AMH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

647113:METOK RS07525
gene id: 647113:METOK_RS07525
uniprot id: F8AK74
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

647113:METOK RS03815
gene id: 647113:METOK_RS03815
uniprot id: F8AM40
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS05255
gene id: 647113:METOK_RS05255
uniprot id: F8ALH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

647113:METOK RS00120
gene id: 647113:METOK_RS00120
uniprot id: F8AMI1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS08110
gene id: 647113:METOK_RS08110
uniprot id: F8AKU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

647113:METOK RS03500
gene id: 647113:METOK_RS03500
uniprot id: F8ALZ3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

647113:METOK RS04305
gene id: 647113:METOK_RS04305
uniprot id: F8AMC3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

647113:METOK RS00805
gene id: 647113:METOK_RS00805
uniprot id: F8AN99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

647113:METOK RS07975
gene id: 647113:METOK_RS07975
uniprot id: F8AKK1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

647113:METOK RS03940
gene id: 647113:METOK_RS03940
uniprot id: F8AM64
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

647113:METOK RS01000
gene id: 647113:METOK_RS01000
uniprot id: F8AND7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

647113:METOK RS01630
gene id: 647113:METOK_RS01630
uniprot id: F8AKC1
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

647113:METOK RS05840
gene id: 647113:METOK_RS05840
uniprot id: F8ANX1
names: Similarity
messages: Belongs to the pyruvate kinase family.

647113:METOK RS02755
gene id: 647113:METOK_RS02755
uniprot id: F8ALE4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

647113:METOK RS07075
gene id: 647113:METOK_RS07075
uniprot id: F8AJZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

647113:METOK RS03810
gene id: 647113:METOK_RS03810
uniprot id: F8AM39
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

647113:METOK RS06845
gene id: 647113:METOK_RS06845
uniprot id: F8AJV7
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06760
gene id: 647113:METOK_RS06760
uniprot id: F8AJU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

647113:METOK RS04050
gene id: 647113:METOK_RS04050
uniprot id: F8AM83
names: Similarity
messages: Belongs to the UPF0210 family.

647113:METOK RS02015
gene id: 647113:METOK_RS02015
uniprot id: F8AKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

647113:METOK RS07460
gene id: 647113:METOK_RS07460
uniprot id: F8AK62
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

647113:METOK RS06050
gene id: 647113:METOK_RS06050
uniprot id: F8ALJ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

647113:METOK RS06790
gene id: 647113:METOK_RS06790
uniprot id: F8AJU8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

647113:METOK RS03660
gene id: 647113:METOK_RS03660
uniprot id: F8AM17
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

647113:METOK RS02010
gene id: 647113:METOK_RS02010
uniprot id: F8AKY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

647113:METOK RS05870
gene id: 647113:METOK_RS05870
uniprot id: F8ANX7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

647113:METOK RS02395
gene id: 647113:METOK_RS02395
uniprot id: F8AL29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

647113:METOK RS07700
gene id: 647113:METOK_RS07700
uniprot id: F8AKF3
names: Similarity
messages: Belongs to the KTI12 family.

647113:METOK RS05215
gene id: 647113:METOK_RS05215
uniprot id: F8AN73
names: Similarity
messages: Belongs to the UPF0173 family.

647113:METOK RS04550
gene id: 647113:METOK_RS04550
uniprot id: F8AMN1
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS04865
gene id: 647113:METOK_RS04865
uniprot id: F8AMT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS04160
gene id: 647113:METOK_RS04160
uniprot id: F8AM97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

647113:METOK RS05465
gene id: 647113:METOK_RS05465
uniprot id: F8ANI5
names: Similarity
messages: Belongs to the FUN14 family.

647113:METOK RS07335
gene id: 647113:METOK_RS07335
uniprot id: F8AK39
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

647113:METOK RS07970
gene id: 647113:METOK_RS07970
uniprot id: F8AKK0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

647113:METOK RS00205
gene id: 647113:METOK_RS00205
uniprot id: F8AMJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

647113:METOK RS05515
gene id: 647113:METOK_RS05515
uniprot id: F8ANJ5
names: Similarity
messages: Belongs to the TrpF family.

647113:METOK RS06830
gene id: 647113:METOK_RS06830
uniprot id: F8AJV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS06490
gene id: 647113:METOK_RS06490
uniprot id: F8AJP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

647113:METOK RS04885
gene id: 647113:METOK_RS04885
uniprot id: F8AMU2
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

647113:METOK RS05710
gene id: 647113:METOK_RS05710
uniprot id: F8ANM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

647113:METOK RS07835
gene id: 647113:METOK_RS07835
uniprot id: F8AKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

647113:METOK RS06630
gene id: 647113:METOK_RS06630
uniprot id: F8AJS1
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS04695
gene id: 647113:METOK_RS04695
uniprot id: F8AMQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS07660
gene id: 647113:METOK_RS07660
uniprot id: F8AK97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

647113:METOK RS01235
gene id: 647113:METOK_RS01235
uniprot id: F8ANP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

647113:METOK RS01320
gene id: 647113:METOK_RS01320
uniprot id: F8ANR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

647113:METOK RS04775
gene id: 647113:METOK_RS04775
uniprot id: F8AMS5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

647113:METOK RS00990
gene id: 647113:METOK_RS00990
uniprot id: F8AND4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

647113:METOK RS03820
gene id: 647113:METOK_RS03820
uniprot id: F8AM41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

647113:METOK RS07945
gene id: 647113:METOK_RS07945
uniprot id: F8AKJ6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

647113:METOK RS05245
gene id: 647113:METOK_RS05245
uniprot id: F8AN78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

647113:METOK RS07955
gene id: 647113:METOK_RS07955
uniprot id: F8AKJ8
names: Similarity
messages: Belongs to the peptidase S49 family.

647113:METOK RS06085
gene id: 647113:METOK_RS06085
uniprot id: F8ALJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

647113:METOK RS06140
gene id: 647113:METOK_RS06140
uniprot id: F8AJI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

647113:METOK RS01245
gene id: 647113:METOK_RS01245
uniprot id: F8ANP7
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03535
gene id: 647113:METOK_RS03535
uniprot id: F8AM00
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS01800
gene id: 647113:METOK_RS01800
uniprot id: F8AKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

647113:METOK RS05010
gene id: 647113:METOK_RS05010
uniprot id: F8AN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

647113:METOK RS03615
gene id: 647113:METOK_RS03615
uniprot id: F8AM11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

647113:METOK RS00300
gene id: 647113:METOK_RS00300
uniprot id: F8AML7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

647113:METOK RS04385
gene id: 647113:METOK_RS04385
uniprot id: F8AMD7
names: Function
names: Similarity
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

647113:METOK RS05885
gene id: 647113:METOK_RS05885
uniprot id: F8ANY0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

647113:METOK RS03240
gene id: 647113:METOK_RS03240
uniprot id: F8ALR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

647113:METOK RS01215
gene id: 647113:METOK_RS01215
uniprot id: F8ANP1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

647113:METOK RS01205
gene id: 647113:METOK_RS01205
uniprot id: F8ANN9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

647113:METOK RS02550
gene id: 647113:METOK_RS02550
uniprot id: F8AL52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

647113:METOK RS06130
gene id: 647113:METOK_RS06130
uniprot id: F8AJI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

647113:METOK RS02735
gene id: 647113:METOK_RS02735
uniprot id: F8ALE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

647113:METOK RS03960
gene id: 647113:METOK_RS03960
uniprot id: F8AL95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

647113:METOK RS07095
gene id: 647113:METOK_RS07095
uniprot id: F8ALT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

647113:METOK RS02705
gene id: 647113:METOK_RS02705
uniprot id: F8ALD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

647113:METOK RS08025
gene id: 647113:METOK_RS08025
uniprot id: F8ALW6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

647113:METOK RS00875
gene id: 647113:METOK_RS00875
uniprot id: F8ANB2
names: Similarity
messages: Belongs to the FrhG family.

647113:METOK RS00160
gene id: 647113:METOK_RS00160
uniprot id: F8AMI9
names: Similarity
messages: Belongs to the HdrC family.

647113:METOK RS01790
gene id: 647113:METOK_RS01790
uniprot id: F8AKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

647113:METOK RS07060
gene id: 647113:METOK_RS07060
uniprot id: F8AJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

647113:METOK RS02375
gene id: 647113:METOK_RS02375
uniprot id: F8AL25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

647113:METOK RS02915
gene id: 647113:METOK_RS02915
uniprot id: F8ALG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

647113:METOK RS03730
gene id: 647113:METOK_RS03730
uniprot id: F8AM26
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

647113:METOK RS03935
gene id: 647113:METOK_RS03935
uniprot id: F8AM63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS02575
gene id: 647113:METOK_RS02575
uniprot id: F8AL57
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS03040
gene id: 647113:METOK_RS03040
uniprot id: F8ALM9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

647113:METOK RS03280
gene id: 647113:METOK_RS03280
uniprot id: F8ALR8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

647113:METOK RS00660
gene id: 647113:METOK_RS00660
uniprot id: F8AN04
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS05985
gene id: 647113:METOK_RS05985
uniprot id: F8ANZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

647113:METOK RS02380
gene id: 647113:METOK_RS02380
uniprot id: F8AL26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

647113:METOK RS05720
gene id: 647113:METOK_RS05720
uniprot id: F8ANU7
names: Similarity
messages: Belongs to the P(II) protein family.

647113:METOK RS03560
gene id: 647113:METOK_RS03560
uniprot id: F8AM05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

647113:METOK RS08035
gene id: 647113:METOK_RS08035
uniprot id: F8AKL0
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

647113:METOK RS07170
gene id: 647113:METOK_RS07170
uniprot id: F8AK14
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

647113:METOK RS04055
gene id: 647113:METOK_RS04055
uniprot id: F8AM84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

647113:METOK RS06525
gene id: 647113:METOK_RS06525
uniprot id: F8AJQ0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

647113:METOK RS07120
gene id: 647113:METOK_RS07120
uniprot id: F8AK04
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

647113:METOK RS04540
gene id: 647113:METOK_RS04540
uniprot id: F8AMF8
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

647113:METOK RS02385
gene id: 647113:METOK_RS02385
uniprot id: F8AL27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS06395
gene id: 647113:METOK_RS06395
uniprot id: F8AJN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

647113:METOK RS03045
gene id: 647113:METOK_RS03045
uniprot id: F8ALN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

647113:METOK RS01075
gene id: 647113:METOK_RS01075
uniprot id: F8ANE8
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS02830
gene id: 647113:METOK_RS02830
uniprot id: F8ALF7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

647113:METOK RS04465
gene id: 647113:METOK_RS04465
uniprot id: F8AME9
names: Similarity
messages: Belongs to the FwdC/FmdC family.

647113:METOK RS03405
gene id: 647113:METOK_RS03405
uniprot id: F8ALX6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

647113:METOK RS03745
gene id: 647113:METOK_RS03745
uniprot id: F8AM29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

647113:METOK RS04320
gene id: 647113:METOK_RS04320
uniprot id: F8AMC6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

647113:METOK RS02400
gene id: 647113:METOK_RS02400
uniprot id: F8AL30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

647113:METOK RS02095
gene id: 647113:METOK_RS02095
uniprot id: F8AKR5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

647113:METOK RS04855
gene id: 647113:METOK_RS04855
uniprot id: F8AMT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS05120
gene id: 647113:METOK_RS05120
uniprot id: F8AN58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS03835
gene id: 647113:METOK_RS03835
uniprot id: F8AM44
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

647113:METOK RS05420
gene id: 647113:METOK_RS05420
uniprot id: F8ANH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

647113:METOK RS03505
gene id: 647113:METOK_RS03505
uniprot id: F8ALZ4
names: Similarity
messages: Belongs to the HerA family.

647113:METOK RS03995
gene id: 647113:METOK_RS03995
uniprot id: F8AM74
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

647113:METOK RS00390
gene id: 647113:METOK_RS00390
uniprot id: F8AMV4
names: Similarity
messages: Belongs to the P(II) protein family.

647113:METOK RS07950
gene id: 647113:METOK_RS07950
uniprot id: F8AKJ7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

647113:METOK RS06610
gene id: 647113:METOK_RS06610
uniprot id: F8AJR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

647113:METOK RS00615
gene id: 647113:METOK_RS00615
uniprot id: F8AMZ8
names: Similarity
messages: Belongs to the UPF0280 family.

647113:METOK RS00170
gene id: 647113:METOK_RS00170
uniprot id: F8AMJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

647113:METOK RS06750
gene id: 647113:METOK_RS06750
uniprot id: F8AJU1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

647113:METOK RS06620
gene id: 647113:METOK_RS06620
uniprot id: F8AJR9
names: Similarity
messages: Belongs to the archaeal ATPase family.

647113:METOK RS05785
gene id: 647113:METOK_RS05785
uniprot id: F8ANW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

647113:METOK RS04655
gene id: 647113:METOK_RS04655
uniprot id: F8AMQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

647113:METOK RS01185
gene id: 647113:METOK_RS01185
uniprot id: F8ANN6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

647113:METOK RS02160
gene id: 647113:METOK_RS02160
uniprot id: F8AKS6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

647113:METOK RS04950
gene id: 647113:METOK_RS04950
uniprot id: F8AN25
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

647113:METOK RS03335
gene id: 647113:METOK_RS03335
uniprot id: F8ALS7
names: Similarity
messages: Belongs to the UPF0273 family.

647113:METOK RS07880
gene id: 647113:METOK_RS07880
uniprot id: F8AKI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

647113:METOK RS02045
gene id: 647113:METOK_RS02045
uniprot id: F8AKQ7
names: Similarity
messages: Belongs to the HMD family.

647113:METOK RS00590
gene id: 647113:METOK_RS00590
uniprot id: F8AMZ3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

647113:METOK RS07325
gene id: 647113:METOK_RS07325
uniprot id: F8AK37
names: Similarity
messages: Belongs to the UPF0216 family.

647113:METOK RS02685
gene id: 647113:METOK_RS02685
uniprot id: F8ALD0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

647113:METOK RS05490
gene id: 647113:METOK_RS05490
uniprot id: F8ANJ0
names: Similarity
messages: Belongs to the UPF0047 family.

647113:METOK RS05775
gene id: 647113:METOK_RS05775
uniprot id: F8ANV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

647113:METOK RS04000
gene id: 647113:METOK_RS04000
uniprot id: F8AM75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS05575
gene id: 647113:METOK_RS05575
uniprot id: F8ANK7
names: Similarity
messages: Belongs to the UPF0305 family.

647113:METOK RS03475
gene id: 647113:METOK_RS03475
uniprot id: F8ALY9
names: Similarity
messages: Belongs to the acylphosphatase family.

647113:METOK RS01420
gene id: 647113:METOK_RS01420
uniprot id: F8ANS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

647113:METOK RS00675
gene id: 647113:METOK_RS00675
uniprot id: F8AN07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

647113:METOK RS03005
gene id: 647113:METOK_RS03005
uniprot id: F8ALM2
names: Similarity
messages: Belongs to the GARS family.

647113:METOK RS03860
gene id: 647113:METOK_RS03860
uniprot id: F8AM49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS07210
gene id: 647113:METOK_RS07210
uniprot id: F8AK21
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

647113:METOK RS00845
gene id: 647113:METOK_RS00845
uniprot id: F8ANA6
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS02220
gene id: 647113:METOK_RS02220
uniprot id: F8AKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

647113:METOK RS01985
gene id: 647113:METOK_RS01985
uniprot id: F8AKP9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

647113:METOK RS08175
gene id: 647113:METOK_RS08175
uniprot id: F8AKV3
names: Similarity
messages: Belongs to the TPP enzyme family.

647113:METOK RS04330
gene id: 647113:METOK_RS04330
uniprot id: F8AMC8
names: Similarity
messages: Belongs to the UPF0201 family.

647113:METOK RS00635
gene id: 647113:METOK_RS00635
uniprot id: F8AKW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

647113:METOK RS02480
gene id: 647113:METOK_RS02480
uniprot id: F8AL44
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS07340
gene id: 647113:METOK_RS07340
uniprot id: F8AK40
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

647113:METOK RS02090
gene id: 647113:METOK_RS02090
uniprot id: F8AKR4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS07300
gene id: 647113:METOK_RS07300
uniprot id: F8AK33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

647113:METOK RS01745
gene id: 647113:METOK_RS01745
uniprot id: F8AKE1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

647113:METOK RS07290
gene id: 647113:METOK_RS07290
uniprot id: F8AK32
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

647113:METOK RS03485
gene id: 647113:METOK_RS03485
uniprot id: F8ALZ0
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06545
gene id: 647113:METOK_RS06545
uniprot id: F8AJQ4
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

647113:METOK RS06370
gene id: 647113:METOK_RS06370
uniprot id: F8AJM7
names: Similarity
messages: Belongs to the UPF0284 family.

647113:METOK RS07840
gene id: 647113:METOK_RS07840
uniprot id: F8AKI1
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

647113:METOK RS04365
gene id: 647113:METOK_RS04365
uniprot id: F8AMD3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

647113:METOK RS00955
gene id: 647113:METOK_RS00955
uniprot id: F8ANC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

647113:METOK RS03490
gene id: 647113:METOK_RS03490
uniprot id: F8ALZ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

647113:METOK RS07465
gene id: 647113:METOK_RS07465
uniprot id: F8AK63
names: Function
messages: Part of a potassium transport system.

647113:METOK RS00565
gene id: 647113:METOK_RS00565
uniprot id: F8AMY8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

647113:METOK RS03800
gene id: 647113:METOK_RS03800
uniprot id: F8AM37
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

647113:METOK RS03870
gene id: 647113:METOK_RS03870
uniprot id: F8AM51
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

647113:METOK RS03130
gene id: 647113:METOK_RS03130
uniprot id: F8ALP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

647113:METOK RS02515
gene id: 647113:METOK_RS02515
uniprot id: F8AL63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

647113:METOK RS05965
gene id: 647113:METOK_RS05965
uniprot id: F8ANZ3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

647113:METOK RS02895
gene id: 647113:METOK_RS02895
uniprot id: F8ALG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

647113:METOK RS01230
gene id: 647113:METOK_RS01230
uniprot id: F8ANP4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

647113:METOK RS00860
gene id: 647113:METOK_RS00860
uniprot id: F8ANA9
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS06075
gene id: 647113:METOK_RS06075
uniprot id: F8ALJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

647113:METOK RS01035
gene id: 647113:METOK_RS01035
uniprot id: F8ANE4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

647113:METOK RS07030
gene id: 647113:METOK_RS07030
uniprot id: F8AJZ0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

647113:METOK RS00310
gene id: 647113:METOK_RS00310
uniprot id: F8AML9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

647113:METOK RS05770
gene id: 647113:METOK_RS05770
uniprot id: F8ANV7
names: Similarity
messages: Belongs to the glutamine synthetase family.

647113:METOK RS06540
gene id: 647113:METOK_RS06540
uniprot id: F8AJQ3
names: Similarity
messages: Belongs to the AOR/FOR family.

647113:METOK RS03930
gene id: 647113:METOK_RS03930
uniprot id: F8AM62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

647113:METOK RS00710
gene id: 647113:METOK_RS00710
uniprot id: F8AN12
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

647113:METOK RS00155
gene id: 647113:METOK_RS00155
uniprot id: F8AMI8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

647113:METOK RS07110
gene id: 647113:METOK_RS07110
uniprot id: F8AK03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

647113:METOK RS06485
gene id: 647113:METOK_RS06485
uniprot id: F8ALL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

647113:METOK RS05370
gene id: 647113:METOK_RS05370
uniprot id: F8ANG6
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS00560
gene id: 647113:METOK_RS00560
uniprot id: F8AMY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

647113:METOK RS04335
gene id: 647113:METOK_RS04335
uniprot id: F8AMC9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

647113:METOK RS04840
gene id: 647113:METOK_RS04840
uniprot id: F8ALH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

647113:METOK RS02415
gene id: 647113:METOK_RS02415
uniprot id: F8AL33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

647113:METOK RS04880
gene id: 647113:METOK_RS04880
uniprot id: F8AMU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

647113:METOK RS03885
gene id: 647113:METOK_RS03885
uniprot id: F8AM54
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03380
gene id: 647113:METOK_RS03380
uniprot id: F8ALX1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

647113:METOK RS03330
gene id: 647113:METOK_RS03330
uniprot id: F8ALS6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

647113:METOK RS06070
gene id: 647113:METOK_RS06070
uniprot id: F8AP09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

647113:METOK RS04300
gene id: 647113:METOK_RS04300
uniprot id: F8AMC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

647113:METOK RS03985
gene id: 647113:METOK_RS03985
uniprot id: F8AM72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS03980
gene id: 647113:METOK_RS03980
uniprot id: F8AM71
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS07345
gene id: 647113:METOK_RS07345
uniprot id: F8AK41
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

647113:METOK RS03790
gene id: 647113:METOK_RS03790
uniprot id: F8AM34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

647113:METOK RS04005
gene id: 647113:METOK_RS04005
uniprot id: F8AM76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

647113:METOK RS06190
gene id: 647113:METOK_RS06190
uniprot id: F8AJJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS06455
gene id: 647113:METOK_RS06455
uniprot id: F8AJN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

647113:METOK RS01395
gene id: 647113:METOK_RS01395
uniprot id: F8ANS5
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03270
gene id: 647113:METOK_RS03270
uniprot id: F8ALR7
names: Similarity
messages: Belongs to the PDCD5 family.

647113:METOK RS00180
gene id: 647113:METOK_RS00180
uniprot id: F8AMJ3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

647113:METOK RS05935
gene id: 647113:METOK_RS05935
uniprot id: F8ANY8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

647113:METOK RS06910
gene id: 647113:METOK_RS06910
uniprot id: F8AJW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS06460
gene id: 647113:METOK_RS06460
uniprot id: F8AJP0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

647113:METOK RS03755
gene id: 647113:METOK_RS03755
uniprot id: F8AM30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

647113:METOK RS01030
gene id: 647113:METOK_RS01030
uniprot id: F8ANE3
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

647113:METOK RS00890
gene id: 647113:METOK_RS00890
uniprot id: F8ANB5
names: Similarity
messages: Belongs to the MvhD/VhuD family.

647113:METOK RS03700
gene id: 647113:METOK_RS03700
uniprot id: F8AM23
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS04285
gene id: 647113:METOK_RS04285
uniprot id: F8AMB9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

647113:METOK RS01160
gene id: 647113:METOK_RS01160
uniprot id: F8ANN1
names: Similarity
messages: Belongs to the UPF0251 family.

647113:METOK RS00380
gene id: 647113:METOK_RS00380
uniprot id: F8AMV2
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

647113:METOK RS06080
gene id: 647113:METOK_RS06080
uniprot id: F8AP10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

647113:METOK RS04345
gene id: 647113:METOK_RS04345
uniprot id: F8AMD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

647113:METOK RS03250
gene id: 647113:METOK_RS03250
uniprot id: F8ALR4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

647113:METOK RS06295
gene id: 647113:METOK_RS06295
uniprot id: F8AJL5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

647113:METOK RS03145
gene id: 647113:METOK_RS03145
uniprot id: F8ALQ1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

647113:METOK RS06550
gene id: 647113:METOK_RS06550
uniprot id: F8AJQ5
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

647113:METOK RS06285
gene id: 647113:METOK_RS06285
uniprot id: F8AJL3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

647113:METOK RS04035
gene id: 647113:METOK_RS04035
uniprot id: F8AM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

647113:METOK RS00075
gene id: 647113:METOK_RS00075
uniprot id: F8AMH2
names: Function
names: Subunit
messages: Homotetramer.
messages: Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.

647113:METOK RS03965
gene id: 647113:METOK_RS03965
uniprot id: F8AM68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS02835
gene id: 647113:METOK_RS02835
uniprot id: F8ALF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS07485
gene id: 647113:METOK_RS07485
uniprot id: F8AK66
names: Similarity
messages: Belongs to the band 7/mec-2 family.

647113:METOK RS03920
gene id: 647113:METOK_RS03920
uniprot id: F8AM60
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

647113:METOK RS02700
gene id: 647113:METOK_RS02700
uniprot id: F8ALD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

647113:METOK RS02765
gene id: 647113:METOK_RS02765
uniprot id: F8ALE6
names: Subcellular Location Annotation
messages: Membrane

647113:METOK RS03945
gene id: 647113:METOK_RS03945
uniprot id: F8AM65
names: Similarity
messages: Belongs to the SUI1 family.

647113:METOK RS05800
gene id: 647113:METOK_RS05800
uniprot id: F8ANW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

647113:METOK RS08050
gene id: 647113:METOK_RS08050
uniprot id: F8AKL3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS05635
gene id: 647113:METOK_RS05635
uniprot id: F8ANL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

647113:METOK RS01260
gene id: 647113:METOK_RS01260
uniprot id: F8ANQ0
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

647113:METOK RS01780
gene id: 647113:METOK_RS01780
uniprot id: F8AKE6
names: Similarity
messages: Belongs to the UPF0200 family.

647113:METOK RS07815
gene id: 647113:METOK_RS07815
uniprot id: F8AKH6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

647113:METOK RS07565
gene id: 647113:METOK_RS07565
uniprot id: F8AK80
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

647113:METOK RS02790
gene id: 647113:METOK_RS02790
uniprot id: F8ALF0
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

647113:METOK RS05730
gene id: 647113:METOK_RS05730
uniprot id: F8ANU9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

647113:METOK RS05525
gene id: 647113:METOK_RS05525
uniprot id: F8ANJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

647113:METOK RS01360
gene id: 647113:METOK_RS01360
uniprot id: F8ANS1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

647113:METOK RS01090
gene id: 647113:METOK_RS01090
uniprot id: F8AKX3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

647113:METOK RS02695
gene id: 647113:METOK_RS02695
uniprot id: F8ALD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

647113:METOK RS01060
gene id: 647113:METOK_RS01060
uniprot id: F8ANE6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

647113:METOK RS06840
gene id: 647113:METOK_RS06840
uniprot id: F8AJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

647113:METOK RS06580
gene id: 647113:METOK_RS06580
uniprot id: F8AJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

647113:METOK RS04410
gene id: 647113:METOK_RS04410
uniprot id: F8AME1
names: Similarity
messages: Belongs to the UPF0146 family.

647113:METOK RS02625
gene id: 647113:METOK_RS02625
uniprot id: F8ALC0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

647113:METOK RS00610
gene id: 647113:METOK_RS00610
uniprot id: F8AMZ7
names: Similarity
messages: Belongs to the thymidylate kinase family.

647113:METOK RS04015
gene id: 647113:METOK_RS04015
uniprot id: F8AM77
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

647113:METOK RS04875
gene id: 647113:METOK_RS04875
uniprot id: F8AMU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

647113:METOK RS04145
gene id: 647113:METOK_RS04145
uniprot id: F8AM94
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

647113:METOK RS07310
gene id: 647113:METOK_RS07310
uniprot id: F8AK35
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

647113:METOK RS04290
gene id: 647113:METOK_RS04290
uniprot id: F8AMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

647113:METOK RS08105
gene id: 647113:METOK_RS08105
uniprot id: F8AKT9
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

647113:METOK RS05060
gene id: 647113:METOK_RS05060
uniprot id: F8AN47
names: Similarity
messages: Belongs to the UPF0179 family.

647113:METOK RS00910
gene id: 647113:METOK_RS00910
uniprot id: F8ANC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

647113:METOK RS03540
gene id: 647113:METOK_RS03540
uniprot id: F8AM01
names: Similarity
messages: Belongs to the MtxX family.

647113:METOK RS02710
gene id: 647113:METOK_RS02710
uniprot id: F8ALD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

647113:METOK RS07440
gene id: 647113:METOK_RS07440
uniprot id: F8AK58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

647113:METOK RS01070
gene id: 647113:METOK_RS01070
uniprot id: F8ANE7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

647113:METOK RS03850
gene id: 647113:METOK_RS03850
uniprot id: F8AM47
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

647113:METOK RS01310
gene id: 647113:METOK_RS01310
uniprot id: F8ANR0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

647113:METOK RS00165
gene id: 647113:METOK_RS00165
uniprot id: F8AMJ0
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

647113:METOK RS07800
gene id: 647113:METOK_RS07800
uniprot id: F8AKH3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

647113:METOK RS03015
gene id: 647113:METOK_RS03015
uniprot id: F8ALM4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

647113:METOK RS02570
gene id: 647113:METOK_RS02570
uniprot id: F8AL56
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

647113:METOK RS06985
gene id: 647113:METOK_RS06985
uniprot id: F8AJY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

647113:METOK RS02880
gene id: 647113:METOK_RS02880
uniprot id: F8AL68
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

647113:METOK RS02510
gene id: 647113:METOK_RS02510
uniprot id: F8AL50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

647113:METOK RS01225
gene id: 647113:METOK_RS01225
uniprot id: F8ANP3
names: Similarity
messages: Belongs to the HypE family.

647113:METOK RS05765
gene id: 647113:METOK_RS05765
uniprot id: F8ANV6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

647113:METOK RS04215
gene id: 647113:METOK_RS04215
uniprot id: F8AMA8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

647113:METOK RS01220
gene id: 647113:METOK_RS01220
uniprot id: F8ANP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

647113:METOK RS01100
gene id: 647113:METOK_RS01100
uniprot id: F8AKX4
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

647113:METOK RS07900
gene id: 647113:METOK_RS07900
uniprot id: F8ALW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

647113:METOK RS05175
gene id: 647113:METOK_RS05175
uniprot id: F8AN66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

647113:METOK RS01635
gene id: 647113:METOK_RS01635
uniprot id: F8AKC2
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

647113:METOK RS04805
gene id: 647113:METOK_RS04805
uniprot id: F8AMT1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

647113:METOK RS00070
gene id: 647113:METOK_RS00070
uniprot id: F8AMH1
names: Similarity
messages: Belongs to the UPF0147 family.

647113:METOK RS04520
gene id: 647113:METOK_RS04520
uniprot id: F8ALB0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

647113:METOK RS07250
gene id: 647113:METOK_RS07250
uniprot id: F8ALU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

647113:METOK RS00600
gene id: 647113:METOK_RS00600
uniprot id: F8AMZ5
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

647113:METOK RS04710
gene id: 647113:METOK_RS04710
uniprot id: F8AMR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

647113:METOK RS03190
gene id: 647113:METOK_RS03190
uniprot id: F8ALQ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

647113:METOK RS04625
gene id: 647113:METOK_RS04625
uniprot id: F8AMP6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

647113:METOK RS00995
gene id: 647113:METOK_RS00995
uniprot id: F8AND5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

647113:METOK RS06505
gene id: 647113:METOK_RS06505
uniprot id: F8ALL2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.