644295:METEV RS10200
gene id: 644295:METEV_RS10200
uniprot id: D7EBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

644295:METEV RS10100
gene id: 644295:METEV_RS10100
uniprot id: D7EBK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS08470
gene id: 644295:METEV_RS08470
uniprot id: D7EB19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

644295:METEV RS07335
gene id: 644295:METEV_RS07335
uniprot id: D7E9Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS05535
gene id: 644295:METEV_RS05535
uniprot id: D7E949
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

644295:METEV RS09170
gene id: 644295:METEV_RS09170
uniprot id: D7EBE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

644295:METEV RS06355
gene id: 644295:METEV_RS06355
uniprot id: D7E7S0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10130
gene id: 644295:METEV_RS10130
uniprot id: D7EBK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS07340
gene id: 644295:METEV_RS07340
uniprot id: D7E9Q2
names: Similarity
messages: Belongs to the DtxR/MntR family.

644295:METEV RS10970
gene id: 644295:METEV_RS10970
uniprot id: D7EAL9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

644295:METEV RS08375
gene id: 644295:METEV_RS08375
uniprot id: D7EB01
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

644295:METEV RS00660
gene id: 644295:METEV_RS00660
uniprot id: D7E637
names: Similarity
messages: Belongs to the phosphohexose mutase family.

644295:METEV RS07075
gene id: 644295:METEV_RS07075
uniprot id: D7E9K4
names: Similarity
messages: Belongs to the TlyA family.

644295:METEV RS09670
gene id: 644295:METEV_RS09670
uniprot id: D7EA88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

644295:METEV RS00970
gene id: 644295:METEV_RS00970
uniprot id: D7E6A3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

644295:METEV RS06535
gene id: 644295:METEV_RS06535
uniprot id: D7E7V2
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10335
gene id: 644295:METEV_RS10335
uniprot id: D7EBP9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

644295:METEV RS08030
gene id: 644295:METEV_RS08030
uniprot id: D7EAT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

644295:METEV RS09310
gene id: 644295:METEV_RS09310
uniprot id: D7EA21
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

644295:METEV RS11135
gene id: 644295:METEV_RS11135
uniprot id: D7EAP8
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS07890
gene id: 644295:METEV_RS07890
uniprot id: D7EAR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

644295:METEV RS10050
gene id: 644295:METEV_RS10050
uniprot id: D7EBJ3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

644295:METEV RS07065
gene id: 644295:METEV_RS07065
uniprot id: D7E9K2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

644295:METEV RS00450
gene id: 644295:METEV_RS00450
uniprot id: D7E5Z5
names: Subcellular Location Annotation
messages: Cytoplasm

644295:METEV RS01405
gene id: 644295:METEV_RS01405
uniprot id: D7E6I8
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS00415
gene id: 644295:METEV_RS00415
uniprot id: D7E5Y8
names: Subcellular Location Annotation
messages: Cell membrane

644295:METEV RS04640
gene id: 644295:METEV_RS04640
uniprot id: D7E783
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

644295:METEV RS08405
gene id: 644295:METEV_RS08405
uniprot id: D7EB07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

644295:METEV RS10935
gene id: 644295:METEV_RS10935
uniprot id: D7EAL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

644295:METEV RS09005
gene id: 644295:METEV_RS09005
uniprot id: D7EBB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

644295:METEV RS01095
gene id: 644295:METEV_RS01095
uniprot id: D7E6C9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

644295:METEV RS10840
gene id: 644295:METEV_RS10840
uniprot id: D7EAJ2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

644295:METEV RS06530
gene id: 644295:METEV_RS06530
uniprot id: D7E7V1
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

644295:METEV RS04980
gene id: 644295:METEV_RS04980
uniprot id: D7E7E7
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS01250
gene id: 644295:METEV_RS01250
uniprot id: D7E6F7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

644295:METEV RS03615
gene id: 644295:METEV_RS03615
uniprot id: D7E710
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

644295:METEV RS11035
gene id: 644295:METEV_RS11035
uniprot id: D7EAN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

644295:METEV RS05640
gene id: 644295:METEV_RS05640
uniprot id: D7E970
names: Similarity
messages: Belongs to the DNA photolyase family.

644295:METEV RS09590
gene id: 644295:METEV_RS09590
uniprot id: D7EA71
names: Similarity
messages: Belongs to the ZPR1 family.

644295:METEV RS04035
gene id: 644295:METEV_RS04035
uniprot id: D7E8P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

644295:METEV RS06665
gene id: 644295:METEV_RS06665
uniprot id: D7E9C8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS06975
gene id: 644295:METEV_RS06975
uniprot id: D7E9I6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS11095
gene id: 644295:METEV_RS11095
uniprot id: D7EAP3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

644295:METEV RS05055
gene id: 644295:METEV_RS05055
uniprot id: D7E7G2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

644295:METEV RS02530
gene id: 644295:METEV_RS02530
uniprot id: D7E880
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

644295:METEV RS05565
gene id: 644295:METEV_RS05565
uniprot id: D7E955
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS08120
gene id: 644295:METEV_RS08120
uniprot id: D7EAV4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

644295:METEV RS06090
gene id: 644295:METEV_RS06090
uniprot id: D7E7M7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

644295:METEV RS05080
gene id: 644295:METEV_RS05080
uniprot id: D7E7G6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

644295:METEV RS10260
gene id: 644295:METEV_RS10260
uniprot id: D7EBN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

644295:METEV RS08445
gene id: 644295:METEV_RS08445
uniprot id: D7EB14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

644295:METEV RS08770
gene id: 644295:METEV_RS08770
uniprot id: D7EB73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

644295:METEV RS10405
gene id: 644295:METEV_RS10405
uniprot id: D7EBR1
names: Similarity
messages: Belongs to the archaeal-type GPI family.

644295:METEV RS07655
gene id: 644295:METEV_RS07655
uniprot id: D7E9W4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS11175
gene id: 644295:METEV_RS11175
uniprot id: D7EAQ6
names: Similarity
messages: Belongs to the TPP enzyme family.

644295:METEV RS11270
gene id: 644295:METEV_RS11270
uniprot id: D7EBU8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

644295:METEV RS06780
gene id: 644295:METEV_RS06780
uniprot id: D7E9E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS04480
gene id: 644295:METEV_RS04480
uniprot id: D7E8X9
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

644295:METEV RS01015
gene id: 644295:METEV_RS01015
uniprot id: D7E6B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

644295:METEV RS02410
gene id: 644295:METEV_RS02410
uniprot id: D7E857
names: Similarity
messages: Belongs to the acylphosphatase family.

644295:METEV RS02900
gene id: 644295:METEV_RS02900
uniprot id: D7E8E7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

644295:METEV RS03610
gene id: 644295:METEV_RS03610
uniprot id: D7E709
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

644295:METEV RS05695
gene id: 644295:METEV_RS05695
uniprot id: D7E981
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

644295:METEV RS07950
gene id: 644295:METEV_RS07950
uniprot id: D7EAS5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

644295:METEV RS00700
gene id: 644295:METEV_RS00700
uniprot id: D7E645
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

644295:METEV RS07785
gene id: 644295:METEV_RS07785
uniprot id: D7E9Y9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS07390
gene id: 644295:METEV_RS07390
uniprot id: D7E9R3
names: Similarity
messages: Belongs to the UPF0228 family.

644295:METEV RS02955
gene id: 644295:METEV_RS02955
uniprot id: D7E8F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

644295:METEV RS04355
gene id: 644295:METEV_RS04355
uniprot id: D7E8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

644295:METEV RS11155
gene id: 644295:METEV_RS11155
uniprot id: D7EAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

644295:METEV RS08460
gene id: 644295:METEV_RS08460
uniprot id: D7EB17
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02805
gene id: 644295:METEV_RS02805
uniprot id: D7E8D0
names: Similarity
messages: Belongs to the UPF0179 family.

644295:METEV RS01595
gene id: 644295:METEV_RS01595
uniprot id: D7E6M4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

644295:METEV RS06995
gene id: 644295:METEV_RS06995
uniprot id: D7E9J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

644295:METEV RS08535
gene id: 644295:METEV_RS08535
uniprot id: D7EB31
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS07575
gene id: 644295:METEV_RS07575
uniprot id: D7E9U9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

644295:METEV RS03825
gene id: 644295:METEV_RS03825
uniprot id: D7E750
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

644295:METEV RS01200
gene id: 644295:METEV_RS01200
uniprot id: D7E6F0
names: Similarity
messages: Belongs to the DEAD box helicase family.

644295:METEV RS03370
gene id: 644295:METEV_RS03370
uniprot id: D7E6W4
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

644295:METEV RS09995
gene id: 644295:METEV_RS09995
uniprot id: D7EBH9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS10945
gene id: 644295:METEV_RS10945
uniprot id: D7EAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

644295:METEV RS01010
gene id: 644295:METEV_RS01010
uniprot id: D7E6B1
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

644295:METEV RS07235
gene id: 644295:METEV_RS07235
uniprot id: D7E9N3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

644295:METEV RS10775
gene id: 644295:METEV_RS10775
uniprot id: D7EAH9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

644295:METEV RS00025
gene id: 644295:METEV_RS00025
uniprot id: D7E5R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

644295:METEV RS02125
gene id: 644295:METEV_RS02125
uniprot id: D7E801
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

644295:METEV RS04175
gene id: 644295:METEV_RS04175
uniprot id: D7E8R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

644295:METEV RS10075
gene id: 644295:METEV_RS10075
uniprot id: D7EBJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS01105
gene id: 644295:METEV_RS01105
uniprot id: D7E6D1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

644295:METEV RS03570
gene id: 644295:METEV_RS03570
uniprot id: D7E701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

644295:METEV RS00045
gene id: 644295:METEV_RS00045
uniprot id: D7E5R9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

644295:METEV RS11070
gene id: 644295:METEV_RS11070
uniprot id: D7EAN8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06520
gene id: 644295:METEV_RS06520
uniprot id: D7E7U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

644295:METEV RS08590
gene id: 644295:METEV_RS08590
uniprot id: D7EB42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

644295:METEV RS07990
gene id: 644295:METEV_RS07990
uniprot id: D7EAT1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

644295:METEV RS03345
gene id: 644295:METEV_RS03345
uniprot id: D7E6V9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

644295:METEV RS04135
gene id: 644295:METEV_RS04135
uniprot id: D7E8R1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

644295:METEV RS01590
gene id: 644295:METEV_RS01590
uniprot id: D7E6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS01090
gene id: 644295:METEV_RS01090
uniprot id: D7E6C8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10875
gene id: 644295:METEV_RS10875
uniprot id: D7EAK0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS05095
gene id: 644295:METEV_RS05095
uniprot id: D7E7G9
names: Similarity
messages: Belongs to the thymidylate kinase family.

644295:METEV RS03965
gene id: 644295:METEV_RS03965
uniprot id: D7E8N1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

644295:METEV RS05145
gene id: 644295:METEV_RS05145
uniprot id: D7E7I0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

644295:METEV RS03980
gene id: 644295:METEV_RS03980
uniprot id: D7E8N4
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

644295:METEV RS08265
gene id: 644295:METEV_RS08265
uniprot id: D7EAY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

644295:METEV RS01295
gene id: 644295:METEV_RS01295
uniprot id: D7E6G6
names: Function
messages: Part of a potassium transport system.

644295:METEV RS03590
gene id: 644295:METEV_RS03590
uniprot id: D7E705
names: Similarity
messages: Belongs to the TrpC family.

644295:METEV RS10565
gene id: 644295:METEV_RS10565
uniprot id: D7EAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

644295:METEV RS10905
gene id: 644295:METEV_RS10905
uniprot id: D7EAK6
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

644295:METEV RS04000
gene id: 644295:METEV_RS04000
uniprot id: D7E8N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

644295:METEV RS04100
gene id: 644295:METEV_RS04100
uniprot id: D7E8Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS01620
gene id: 644295:METEV_RS01620
uniprot id: D7E6M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS08385
gene id: 644295:METEV_RS08385
uniprot id: D7EB03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

644295:METEV RS06570
gene id: 644295:METEV_RS06570
uniprot id: D7E9B0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

644295:METEV RS00630
gene id: 644295:METEV_RS00630
uniprot id: D7E630
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

644295:METEV RS00690
gene id: 644295:METEV_RS00690
uniprot id: D7E643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

644295:METEV RS00610
gene id: 644295:METEV_RS00610
uniprot id: D7E626
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

644295:METEV RS05930
gene id: 644295:METEV_RS05930
uniprot id: D7E7J8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

644295:METEV RS10125
gene id: 644295:METEV_RS10125
uniprot id: D7EBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS08580
gene id: 644295:METEV_RS08580
uniprot id: D7EB40
names: Similarity
messages: Belongs to the UPF0147 family.

644295:METEV RS02830
gene id: 644295:METEV_RS02830
uniprot id: D7E8D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

644295:METEV RS08555
gene id: 644295:METEV_RS08555
uniprot id: D7EB35
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

644295:METEV RS02105
gene id: 644295:METEV_RS02105
uniprot id: D7E7Z7
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

644295:METEV RS09455
gene id: 644295:METEV_RS09455
uniprot id: D7EA45
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

644295:METEV RS08565
gene id: 644295:METEV_RS08565
uniprot id: D7EB37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

644295:METEV RS04260
gene id: 644295:METEV_RS04260
uniprot id: D7E8T7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

644295:METEV RS04015
gene id: 644295:METEV_RS04015
uniprot id: D7E8N9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS00885
gene id: 644295:METEV_RS00885
uniprot id: D7E687
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

644295:METEV RS09400
gene id: 644295:METEV_RS09400
uniprot id: D7EA36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS08335
gene id: 644295:METEV_RS08335
uniprot id: D7EAZ4
names: Similarity
messages: Belongs to the class-I fumarase family.

644295:METEV RS05860
gene id: 644295:METEV_RS05860
uniprot id: D7E9A8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

644295:METEV RS07350
gene id: 644295:METEV_RS07350
uniprot id: D7E9Q4
names: Similarity
messages: Belongs to the HdrC family.

644295:METEV RS10165
gene id: 644295:METEV_RS10165
uniprot id: D7EBL6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

644295:METEV RS02685
gene id: 644295:METEV_RS02685
uniprot id: D7E8A8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

644295:METEV RS08850
gene id: 644295:METEV_RS08850
uniprot id: D7EB87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS04710
gene id: 644295:METEV_RS04710
uniprot id: D7E796
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

644295:METEV RS07185
gene id: 644295:METEV_RS07185
uniprot id: D7E9M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

644295:METEV RS10855
gene id: 644295:METEV_RS10855
uniprot id: D7EAJ5
names: Similarity
messages: Belongs to the SUI1 family.

644295:METEV RS03650
gene id: 644295:METEV_RS03650
uniprot id: D7E718
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

644295:METEV RS09345
gene id: 644295:METEV_RS09345
uniprot id: D7EA27
names: Similarity
messages: Belongs to the UPF0047 family.

644295:METEV RS02980
gene id: 644295:METEV_RS02980
uniprot id: D7E8G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

644295:METEV RS05775
gene id: 644295:METEV_RS05775
uniprot id: D7E995
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

644295:METEV RS00275
gene id: 644295:METEV_RS00275
uniprot id: D7E5W0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS01290
gene id: 644295:METEV_RS01290
uniprot id: D7E6G5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

644295:METEV RS08970
gene id: 644295:METEV_RS08970
uniprot id: D7EBB0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS04500
gene id: 644295:METEV_RS04500
uniprot id: D7E8Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

644295:METEV RS05600
gene id: 644295:METEV_RS05600
uniprot id: D7E963
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

644295:METEV RS00005
gene id: 644295:METEV_RS00005
uniprot id: D7E5R1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

644295:METEV RS07470
gene id: 644295:METEV_RS07470
uniprot id: D7E9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

644295:METEV RS05005
gene id: 644295:METEV_RS05005
uniprot id: D7E7F2
names: Similarity
messages: Belongs to the peptidase C56 family.

644295:METEV RS06980
gene id: 644295:METEV_RS06980
uniprot id: D7E9I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

644295:METEV RS05610
gene id: 644295:METEV_RS05610
uniprot id: D7E965
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

644295:METEV RS10655
gene id: 644295:METEV_RS10655
uniprot id: D7EAF5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

644295:METEV RS10070
gene id: 644295:METEV_RS10070
uniprot id: D7EBJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

644295:METEV RS08075
gene id: 644295:METEV_RS08075
uniprot id: D7EAU5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

644295:METEV RS01400
gene id: 644295:METEV_RS01400
uniprot id: D7E6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

644295:METEV RS03665
gene id: 644295:METEV_RS03665
uniprot id: D7E721
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

644295:METEV RS07495
gene id: 644295:METEV_RS07495
uniprot id: D7E9T3
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04150
gene id: 644295:METEV_RS04150
uniprot id: D7E8R4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS03970
gene id: 644295:METEV_RS03970
uniprot id: D7E8N2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

644295:METEV RS01475
gene id: 644295:METEV_RS01475
uniprot id: D7E6K1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS00150
gene id: 644295:METEV_RS00150
uniprot id: D7E5U0
names: Subcellular Location Annotation
messages: Cytoplasm

644295:METEV RS02915
gene id: 644295:METEV_RS02915
uniprot id: D7E8F2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

644295:METEV RS09675
gene id: 644295:METEV_RS09675
uniprot id: D7EA89
names: Similarity
messages: Belongs to the FBPase class 2 family.

644295:METEV RS07165
gene id: 644295:METEV_RS07165
uniprot id: D7E9M0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS07255
gene id: 644295:METEV_RS07255
uniprot id: D7E9N7
names: Function
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

644295:METEV RS05815
gene id: 644295:METEV_RS05815
uniprot id: D7E9A2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS06855
gene id: 644295:METEV_RS06855
uniprot id: D7E9G0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

644295:METEV RS08450
gene id: 644295:METEV_RS08450
uniprot id: D7EB15
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

644295:METEV RS04080
gene id: 644295:METEV_RS04080
uniprot id: D7E8Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS03855
gene id: 644295:METEV_RS03855
uniprot id: D7E756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

644295:METEV RS08550
gene id: 644295:METEV_RS08550
uniprot id: D7EB34
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS05555
gene id: 644295:METEV_RS05555
uniprot id: D7E953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

644295:METEV RS05035
gene id: 644295:METEV_RS05035
uniprot id: D7E7F8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

644295:METEV RS01435
gene id: 644295:METEV_RS01435
uniprot id: D7E6J4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10950
gene id: 644295:METEV_RS10950
uniprot id: D7EAL5
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04130
gene id: 644295:METEV_RS04130
uniprot id: D7E8R0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS07130
gene id: 644295:METEV_RS07130
uniprot id: D7E9L3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS07060
gene id: 644295:METEV_RS07060
uniprot id: D7E9K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

644295:METEV RS00190
gene id: 644295:METEV_RS00190
uniprot id: D7E5U8
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

644295:METEV RS05245
gene id: 644295:METEV_RS05245
uniprot id: D7E8Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

644295:METEV RS01575
gene id: 644295:METEV_RS01575
uniprot id: D7E6M1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

644295:METEV RS00140
gene id: 644295:METEV_RS00140
uniprot id: D7E5T8
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

644295:METEV RS03655
gene id: 644295:METEV_RS03655
uniprot id: D7E719
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

644295:METEV RS07230
gene id: 644295:METEV_RS07230
uniprot id: D7E9N2
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

644295:METEV RS08085
gene id: 644295:METEV_RS08085
uniprot id: D7EAU7
names: Similarity
messages: Belongs to the UPF0282 family.

644295:METEV RS10715
gene id: 644295:METEV_RS10715
uniprot id: D7EAG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

644295:METEV RS02460
gene id: 644295:METEV_RS02460
uniprot id: D7E867
names: Similarity
messages: Belongs to the MoaB/Mog family.

644295:METEV RS09435
gene id: 644295:METEV_RS09435
uniprot id: D7EA42
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09030
gene id: 644295:METEV_RS09030
uniprot id: D7EBC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

644295:METEV RS09925
gene id: 644295:METEV_RS09925
uniprot id: D7EBG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS01905
gene id: 644295:METEV_RS01905
uniprot id: D7E7W0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS02990
gene id: 644295:METEV_RS02990
uniprot id: D7E8G6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

644295:METEV RS08290
gene id: 644295:METEV_RS08290
uniprot id: D7EAY6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

644295:METEV RS06810
gene id: 644295:METEV_RS06810
uniprot id: D7E9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

644295:METEV RS04290
gene id: 644295:METEV_RS04290
uniprot id: D7E8U3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

644295:METEV RS00545
gene id: 644295:METEV_RS00545
uniprot id: D7E614
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

644295:METEV RS04835
gene id: 644295:METEV_RS04835
uniprot id: D7E7C1
names: Similarity
messages: Belongs to the oxoprolinase family.

644295:METEV RS06170
gene id: 644295:METEV_RS06170
uniprot id: D7E7P1
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10285
gene id: 644295:METEV_RS10285
uniprot id: D7EBP1
names: Similarity
messages: Belongs to the UPF0107 family.

644295:METEV RS01600
gene id: 644295:METEV_RS01600
uniprot id: D7E6M5
names: Similarity
messages: Belongs to the MEMO1 family.

644295:METEV RS09145
gene id: 644295:METEV_RS09145
uniprot id: D7EBE5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

644295:METEV RS00600
gene id: 644295:METEV_RS00600
uniprot id: D7E624
names: Similarity
messages: Belongs to the UPF0235 family.

644295:METEV RS09085
gene id: 644295:METEV_RS09085
uniprot id: D7EBD3
names: Similarity
messages: Belongs to the UPF0288 family.

644295:METEV RS07615
gene id: 644295:METEV_RS07615
uniprot id: D7E9V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

644295:METEV RS11075
gene id: 644295:METEV_RS11075
uniprot id: D7EAN9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS11100
gene id: 644295:METEV_RS11100
uniprot id: D7EAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

644295:METEV RS01175
gene id: 644295:METEV_RS01175
uniprot id: D7E6E5
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

644295:METEV RS06800
gene id: 644295:METEV_RS06800
uniprot id: D7E9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

644295:METEV RS10115
gene id: 644295:METEV_RS10115
uniprot id: D7EBK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS06165
gene id: 644295:METEV_RS06165
uniprot id: D7E7P0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10170
gene id: 644295:METEV_RS10170
uniprot id: D7EBL7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

644295:METEV RS04460
gene id: 644295:METEV_RS04460
uniprot id: D7E8X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

644295:METEV RS04415
gene id: 644295:METEV_RS04415
uniprot id: D7E8W6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

644295:METEV RS04250
gene id: 644295:METEV_RS04250
uniprot id: D7E8T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

644295:METEV RS07100
gene id: 644295:METEV_RS07100
uniprot id: D7E9K8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS07045
gene id: 644295:METEV_RS07045
uniprot id: D7E9J8
names: Similarity
messages: Belongs to the UPF0212 family.

644295:METEV RS02660
gene id: 644295:METEV_RS02660
uniprot id: D7E8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

644295:METEV RS03975
gene id: 644295:METEV_RS03975
uniprot id: D7E8N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

644295:METEV RS10980
gene id: 644295:METEV_RS10980
uniprot id: D7EAM1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

644295:METEV RS09930
gene id: 644295:METEV_RS09930
uniprot id: D7EBG8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

644295:METEV RS07055
gene id: 644295:METEV_RS07055
uniprot id: D7E9K0
names: Similarity
messages: Belongs to the HerA family.

644295:METEV RS01830
gene id: 644295:METEV_RS01830
uniprot id: D7E6R7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS06455
gene id: 644295:METEV_RS06455
uniprot id: D7E7T7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS01615
gene id: 644295:METEV_RS01615
uniprot id: D7E6M8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS11415
gene id: 644295:METEV_RS11415
uniprot id: D7EBX2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS06860
gene id: 644295:METEV_RS06860
uniprot id: D7E9G1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

644295:METEV RS03915
gene id: 644295:METEV_RS03915
uniprot id: D7E8M0
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

644295:METEV RS10205
gene id: 644295:METEV_RS10205
uniprot id: D7EBM4
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

644295:METEV RS05945
gene id: 644295:METEV_RS05945
uniprot id: D7E7K1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS10890
gene id: 644295:METEV_RS10890
uniprot id: D7EAK3
names: Similarity
messages: Belongs to the LarC family.

644295:METEV RS01185
gene id: 644295:METEV_RS01185
uniprot id: D7E6E7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

644295:METEV RS03505
gene id: 644295:METEV_RS03505
uniprot id: D7E6Y8
names: Subcellular Location Annotation
messages: Cytoplasm

644295:METEV RS10580
gene id: 644295:METEV_RS10580
uniprot id: D7EAE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

644295:METEV RS08345
gene id: 644295:METEV_RS08345
uniprot id: D7EAZ6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS06695
gene id: 644295:METEV_RS06695
uniprot id: D7E9D2
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

644295:METEV RS00535
gene id: 644295:METEV_RS00535
uniprot id: D7E612
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02965
gene id: 644295:METEV_RS02965
uniprot id: D7E8G1
names: Function
messages: Probably involved in the biogenesis of the ribosome.

644295:METEV RS06900
gene id: 644295:METEV_RS06900
uniprot id: D7E9H0
names: Similarity
messages: Belongs to the MtrH family.

644295:METEV RS09575
gene id: 644295:METEV_RS09575
uniprot id: D7EA68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

644295:METEV RS03595
gene id: 644295:METEV_RS03595
uniprot id: D7E706
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

644295:METEV RS11840
gene id: 644295:METEV_RS11840
uniprot id: D7EC59
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS01605
gene id: 644295:METEV_RS01605
uniprot id: D7E6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS01020
gene id: 644295:METEV_RS01020
uniprot id: D7E6B3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS10955
gene id: 644295:METEV_RS10955
uniprot id: D7EAL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

644295:METEV RS03510
gene id: 644295:METEV_RS03510
uniprot id: D7E6Y9
names: Similarity
messages: Belongs to the glutaredoxin family.

644295:METEV RS02520
gene id: 644295:METEV_RS02520
uniprot id: D7E878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

644295:METEV RS05030
gene id: 644295:METEV_RS05030
uniprot id: D7E7F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

644295:METEV RS10615
gene id: 644295:METEV_RS10615
uniprot id: D7EAE7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS09375
gene id: 644295:METEV_RS09375
uniprot id: D7EA32
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

644295:METEV RS02060
gene id: 644295:METEV_RS02060
uniprot id: D7E7Y8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

644295:METEV RS06760
gene id: 644295:METEV_RS06760
uniprot id: D7E9E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS01525
gene id: 644295:METEV_RS01525
uniprot id: D7E6L1
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

644295:METEV RS00455
gene id: 644295:METEV_RS00455
uniprot id: D7E5Z6
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

644295:METEV RS00880
gene id: 644295:METEV_RS00880
uniprot id: D7E686
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

644295:METEV RS11000
gene id: 644295:METEV_RS11000
uniprot id: D7EAM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

644295:METEV RS00940
gene id: 644295:METEV_RS00940
uniprot id: D7E697
names: Similarity
messages: Belongs to the AAA ATPase family.

644295:METEV RS04580
gene id: 644295:METEV_RS04580
uniprot id: D7E772
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

644295:METEV RS01085
gene id: 644295:METEV_RS01085
uniprot id: D7E6C7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

644295:METEV RS07535
gene id: 644295:METEV_RS07535
uniprot id: D7E9U1
names: Similarity
messages: Belongs to the glutamate synthase family.

644295:METEV RS04945
gene id: 644295:METEV_RS04945
uniprot id: D7E7E1
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

644295:METEV RS09710
gene id: 644295:METEV_RS09710
uniprot id: D7EA96
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

644295:METEV RS10835
gene id: 644295:METEV_RS10835
uniprot id: D7EAJ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

644295:METEV RS04255
gene id: 644295:METEV_RS04255
uniprot id: D7E8T6
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

644295:METEV RS10940
gene id: 644295:METEV_RS10940
uniprot id: D7EAL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

644295:METEV RS05700
gene id: 644295:METEV_RS05700
uniprot id: D7E982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

644295:METEV RS07925
gene id: 644295:METEV_RS07925
uniprot id: D7EAS0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

644295:METEV RS00935
gene id: 644295:METEV_RS00935
uniprot id: D7E696
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02840
gene id: 644295:METEV_RS02840
uniprot id: D7E8D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

644295:METEV RS11405
gene id: 644295:METEV_RS11405
uniprot id: D7EBX0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

644295:METEV RS06745
gene id: 644295:METEV_RS06745
uniprot id: D7E9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

644295:METEV RS10210
gene id: 644295:METEV_RS10210
uniprot id: D7EBM5
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

644295:METEV RS09890
gene id: 644295:METEV_RS09890
uniprot id: D7EBG0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

644295:METEV RS09135
gene id: 644295:METEV_RS09135
uniprot id: D7EBE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

644295:METEV RS08295
gene id: 644295:METEV_RS08295
uniprot id: D7EAY7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

644295:METEV RS10910
gene id: 644295:METEV_RS10910
uniprot id: D7EAK7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

644295:METEV RS06930
gene id: 644295:METEV_RS06930
uniprot id: D7E9H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

644295:METEV RS02405
gene id: 644295:METEV_RS02405
uniprot id: D7E856
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS01300
gene id: 644295:METEV_RS01300
uniprot id: D7E6G7
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08940
gene id: 644295:METEV_RS08940
uniprot id: D7EBA4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS07675
gene id: 644295:METEV_RS07675
uniprot id: D7E9W8
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

644295:METEV RS10560
gene id: 644295:METEV_RS10560
uniprot id: D7EAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

644295:METEV RS08845
gene id: 644295:METEV_RS08845
uniprot id: D7EB86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

644295:METEV RS05260
gene id: 644295:METEV_RS05260
uniprot id: D7E902
names: Similarity
messages: Belongs to the DMRL synthase family.

644295:METEV RS02160
gene id: 644295:METEV_RS02160
uniprot id: D7E808
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

644295:METEV RS09600
gene id: 644295:METEV_RS09600
uniprot id: D7EA73
names: Similarity
messages: Belongs to the UPF0284 family.

644295:METEV RS06235
gene id: 644295:METEV_RS06235
uniprot id: D7E7Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

644295:METEV RS02970
gene id: 644295:METEV_RS02970
uniprot id: D7E8G3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS04230
gene id: 644295:METEV_RS04230
uniprot id: D7E8T1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

644295:METEV RS02545
gene id: 644295:METEV_RS02545
uniprot id: D7E883
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

644295:METEV RS07275
gene id: 644295:METEV_RS07275
uniprot id: D7E9P0
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

644295:METEV RS10665
gene id: 644295:METEV_RS10665
uniprot id: D7EAF7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

644295:METEV RS04195
gene id: 644295:METEV_RS04195
uniprot id: D7E8S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS00995
gene id: 644295:METEV_RS00995
uniprot id: D7E6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

644295:METEV RS09050
gene id: 644295:METEV_RS09050
uniprot id: D7EBC6
names: Similarity
messages: Belongs to the AOR/FOR family.

644295:METEV RS04205
gene id: 644295:METEV_RS04205
uniprot id: D7E8S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS07040
gene id: 644295:METEV_RS07040
uniprot id: D7E9J7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

644295:METEV RS07450
gene id: 644295:METEV_RS07450
uniprot id: D7E9S4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04465
gene id: 644295:METEV_RS04465
uniprot id: D7E8X6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

644295:METEV RS08645
gene id: 644295:METEV_RS08645
uniprot id: D7EB54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

644295:METEV RS04330
gene id: 644295:METEV_RS04330
uniprot id: D7E8V1
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

644295:METEV RS10265
gene id: 644295:METEV_RS10265
uniprot id: D7EBN6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

644295:METEV RS04045
gene id: 644295:METEV_RS04045
uniprot id: D7E8P5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

644295:METEV RS08195
gene id: 644295:METEV_RS08195
uniprot id: D7EAW7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

644295:METEV RS01695
gene id: 644295:METEV_RS01695
uniprot id: D7E6P2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

644295:METEV RS04350
gene id: 644295:METEV_RS04350
uniprot id: D7E8V5
names: Similarity
messages: Belongs to the GARS family.

644295:METEV RS08715
gene id: 644295:METEV_RS08715
uniprot id: D7EB63
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

644295:METEV RS02505
gene id: 644295:METEV_RS02505
uniprot id: D7E875
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10985
gene id: 644295:METEV_RS10985
uniprot id: D7EAM2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS08380
gene id: 644295:METEV_RS08380
uniprot id: D7EB02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

644295:METEV RS06630
gene id: 644295:METEV_RS06630
uniprot id: D7E9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

644295:METEV RS01125
gene id: 644295:METEV_RS01125
uniprot id: D7E6D5
names: Similarity
messages: Belongs to the Ahb/Nir family.

644295:METEV RS11670
gene id: 644295:METEV_RS11670
uniprot id: D7EC19
names: Similarity
messages: Belongs to the UPF0228 family.

644295:METEV RS10020
gene id: 644295:METEV_RS10020
uniprot id: D7EBI7
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

644295:METEV RS07210
gene id: 644295:METEV_RS07210
uniprot id: D7E9M8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS08480
gene id: 644295:METEV_RS08480
uniprot id: D7EB21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

644295:METEV RS11325
gene id: 644295:METEV_RS11325
uniprot id: D7EBV8
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

644295:METEV RS00530
gene id: 644295:METEV_RS00530
uniprot id: D7E611
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

644295:METEV RS02425
gene id: 644295:METEV_RS02425
uniprot id: D7E860
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

644295:METEV RS08395
gene id: 644295:METEV_RS08395
uniprot id: D7EB05
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

644295:METEV RS06765
gene id: 644295:METEV_RS06765
uniprot id: D7E9E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

644295:METEV RS00340
gene id: 644295:METEV_RS00340
uniprot id: D7E5X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

644295:METEV RS04575
gene id: 644295:METEV_RS04575
uniprot id: D7E771
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS02615
gene id: 644295:METEV_RS02615
uniprot id: D7E894
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

644295:METEV RS09905
gene id: 644295:METEV_RS09905
uniprot id: D7EBG3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

644295:METEV RS04490
gene id: 644295:METEV_RS04490
uniprot id: D7E8Y1
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

644295:METEV RS10570
gene id: 644295:METEV_RS10570
uniprot id: D7EAD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

644295:METEV RS03470
gene id: 644295:METEV_RS03470
uniprot id: D7E6Y3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS00685
gene id: 644295:METEV_RS00685
uniprot id: D7E642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

644295:METEV RS07720
gene id: 644295:METEV_RS07720
uniprot id: D7E9X8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

644295:METEV RS09895
gene id: 644295:METEV_RS09895
uniprot id: D7EBG1
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

644295:METEV RS02860
gene id: 644295:METEV_RS02860
uniprot id: D7E8E1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS08045
gene id: 644295:METEV_RS08045
uniprot id: D7EAU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

644295:METEV RS01165
gene id: 644295:METEV_RS01165
uniprot id: D7E6E3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

644295:METEV RS08985
gene id: 644295:METEV_RS08985
uniprot id: D7EBB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

644295:METEV RS09045
gene id: 644295:METEV_RS09045
uniprot id: D7EBC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

644295:METEV RS03625
gene id: 644295:METEV_RS03625
uniprot id: D7E712
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

644295:METEV RS10525
gene id: 644295:METEV_RS10525
uniprot id: D7EBT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

644295:METEV RS04730
gene id: 644295:METEV_RS04730
uniprot id: D7E7A0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04170
gene id: 644295:METEV_RS04170
uniprot id: D7E8R8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

644295:METEV RS04055
gene id: 644295:METEV_RS04055
uniprot id: D7E8P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

644295:METEV RS01055
gene id: 644295:METEV_RS01055
uniprot id: D7E6C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

644295:METEV RS05580
gene id: 644295:METEV_RS05580
uniprot id: D7E958
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

644295:METEV RS04910
gene id: 644295:METEV_RS04910
uniprot id: D7E7D4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS06990
gene id: 644295:METEV_RS06990
uniprot id: D7E9I9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

644295:METEV RS09685
gene id: 644295:METEV_RS09685
uniprot id: D7EA91
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

644295:METEV RS05265
gene id: 644295:METEV_RS05265
uniprot id: D7E903
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

644295:METEV RS10960
gene id: 644295:METEV_RS10960
uniprot id: D7EAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

644295:METEV RS06985
gene id: 644295:METEV_RS06985
uniprot id: D7E9I8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

644295:METEV RS05290
gene id: 644295:METEV_RS05290
uniprot id: D7E907
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS10400
gene id: 644295:METEV_RS10400
uniprot id: D7EBR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

644295:METEV RS01315
gene id: 644295:METEV_RS01315
uniprot id: D7E6H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

644295:METEV RS08710
gene id: 644295:METEV_RS08710
uniprot id: D7EB62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

644295:METEV RS01540
gene id: 644295:METEV_RS01540
uniprot id: D7E6L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

644295:METEV RS10975
gene id: 644295:METEV_RS10975
uniprot id: D7EAM0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

644295:METEV RS08810
gene id: 644295:METEV_RS08810
uniprot id: D7EB79
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS08615
gene id: 644295:METEV_RS08615
uniprot id: D7EB48
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

644295:METEV RS10135
gene id: 644295:METEV_RS10135
uniprot id: D7EBL0
names: Similarity
messages: Belongs to the MtrH family.

644295:METEV RS09065
gene id: 644295:METEV_RS09065
uniprot id: D7EBC9
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

644295:METEV RS04155
gene id: 644295:METEV_RS04155
uniprot id: D7E8R5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

644295:METEV RS04615
gene id: 644295:METEV_RS04615
uniprot id: D7E778
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

644295:METEV RS02415
gene id: 644295:METEV_RS02415
uniprot id: D7E858
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10465
gene id: 644295:METEV_RS10465
uniprot id: D7EBS4
names: Similarity
messages: Belongs to the DtxR/MntR family.

644295:METEV RS01440
gene id: 644295:METEV_RS01440
uniprot id: D7E6J5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

644295:METEV RS10415
gene id: 644295:METEV_RS10415
uniprot id: D7EBR3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

644295:METEV RS11110
gene id: 644295:METEV_RS11110
uniprot id: D7EAP6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

644295:METEV RS08925
gene id: 644295:METEV_RS08925
uniprot id: D7EBA1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02225
gene id: 644295:METEV_RS02225
uniprot id: D7E818
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS05460
gene id: 644295:METEV_RS05460
uniprot id: D7E934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

644295:METEV RS02775
gene id: 644295:METEV_RS02775
uniprot id: D7E8C4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

644295:METEV RS04530
gene id: 644295:METEV_RS04530
uniprot id: D7E762
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10345
gene id: 644295:METEV_RS10345
uniprot id: D7EBQ1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

644295:METEV RS06130
gene id: 644295:METEV_RS06130
uniprot id: D7E7N5
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

644295:METEV RS03600
gene id: 644295:METEV_RS03600
uniprot id: D7E707
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

644295:METEV RS06180
gene id: 644295:METEV_RS06180
uniprot id: D7E7P3
names: Subcellular Location Annotation
messages: Cell membrane

644295:METEV RS01305
gene id: 644295:METEV_RS01305
uniprot id: D7E6G8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

644295:METEV RS10120
gene id: 644295:METEV_RS10120
uniprot id: D7EBK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS08320
gene id: 644295:METEV_RS08320
uniprot id: D7EAZ2
names: Similarity
messages: Belongs to the CutA family.

644295:METEV RS09855
gene id: 644295:METEV_RS09855
uniprot id: D7EAC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

644295:METEV RS02590
gene id: 644295:METEV_RS02590
uniprot id: D7E889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

644295:METEV RS08905
gene id: 644295:METEV_RS08905
uniprot id: D7EB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

644295:METEV RS05550
gene id: 644295:METEV_RS05550
uniprot id: D7E952
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

644295:METEV RS10915
gene id: 644295:METEV_RS10915
uniprot id: D7EAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

644295:METEV RS03985
gene id: 644295:METEV_RS03985
uniprot id: D7E8N5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS01320
gene id: 644295:METEV_RS01320
uniprot id: D7E6H1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

644295:METEV RS04555
gene id: 644295:METEV_RS04555
uniprot id: D7E767
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS01190
gene id: 644295:METEV_RS01190
uniprot id: D7E6E8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

644295:METEV RS01640
gene id: 644295:METEV_RS01640
uniprot id: D7E6N2
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

644295:METEV RS02330
gene id: 644295:METEV_RS02330
uniprot id: D7E839
names: Similarity
messages: Belongs to the TBP family.

644295:METEV RS00900
gene id: 644295:METEV_RS00900
uniprot id: D7E690
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

644295:METEV RS06805
gene id: 644295:METEV_RS06805
uniprot id: D7E9F2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

644295:METEV RS03850
gene id: 644295:METEV_RS03850
uniprot id: D7E755
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

644295:METEV RS00360
gene id: 644295:METEV_RS00360
uniprot id: D7E5X7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS04020
gene id: 644295:METEV_RS04020
uniprot id: D7E8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

644295:METEV RS01550
gene id: 644295:METEV_RS01550
uniprot id: D7E6L6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

644295:METEV RS08885
gene id: 644295:METEV_RS08885
uniprot id: D7EB94
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

644295:METEV RS04550
gene id: 644295:METEV_RS04550
uniprot id: D7E766
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS00960
gene id: 644295:METEV_RS00960
uniprot id: D7E6A1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS08750
gene id: 644295:METEV_RS08750
uniprot id: D7EB69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

644295:METEV RS02855
gene id: 644295:METEV_RS02855
uniprot id: D7E8E0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

644295:METEV RS01825
gene id: 644295:METEV_RS01825
uniprot id: D7E6R6
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09515
gene id: 644295:METEV_RS09515
uniprot id: D7EA57
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

644295:METEV RS09775
gene id: 644295:METEV_RS09775
uniprot id: D7EAA9
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS05575
gene id: 644295:METEV_RS05575
uniprot id: D7E957
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

644295:METEV RS03670
gene id: 644295:METEV_RS03670
uniprot id: D7E722
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

644295:METEV RS03890
gene id: 644295:METEV_RS03890
uniprot id: D7E8L5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

644295:METEV RS04030
gene id: 644295:METEV_RS04030
uniprot id: D7E8P2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

644295:METEV RS00460
gene id: 644295:METEV_RS00460
uniprot id: D7E5Z7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS07700
gene id: 644295:METEV_RS07700
uniprot id: D7E9X3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

644295:METEV RS04525
gene id: 644295:METEV_RS04525
uniprot id: D7E761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

644295:METEV RS07650
gene id: 644295:METEV_RS07650
uniprot id: D7E9W3
names: Similarity
messages: Belongs to the pyruvate kinase family.

644295:METEV RS00430
gene id: 644295:METEV_RS00430
uniprot id: D7E5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

644295:METEV RS03885
gene id: 644295:METEV_RS03885
uniprot id: D7E8L4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

644295:METEV RS03000
gene id: 644295:METEV_RS03000
uniprot id: D7E8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

644295:METEV RS04715
gene id: 644295:METEV_RS04715
uniprot id: D7E797
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS02995
gene id: 644295:METEV_RS02995
uniprot id: D7E8G7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

644295:METEV RS06580
gene id: 644295:METEV_RS06580
uniprot id: D7E9B2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS07115
gene id: 644295:METEV_RS07115
uniprot id: D7E9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

644295:METEV RS04180
gene id: 644295:METEV_RS04180
uniprot id: D7E8S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS00355
gene id: 644295:METEV_RS00355
uniprot id: D7E5X6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06755
gene id: 644295:METEV_RS06755
uniprot id: D7E9E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

644295:METEV RS06950
gene id: 644295:METEV_RS06950
uniprot id: D7E9I1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

644295:METEV RS00910
gene id: 644295:METEV_RS00910
uniprot id: D7E692
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

644295:METEV RS08165
gene id: 644295:METEV_RS08165
uniprot id: D7EAW1
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

644295:METEV RS05185
gene id: 644295:METEV_RS05185
uniprot id: D7E8Y6
names: Similarity
messages: Belongs to the IMPACT family.

644295:METEV RS06960
gene id: 644295:METEV_RS06960
uniprot id: D7E9I3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

644295:METEV RS04140
gene id: 644295:METEV_RS04140
uniprot id: D7E8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

644295:METEV RS03840
gene id: 644295:METEV_RS03840
uniprot id: D7E753
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

644295:METEV RS08340
gene id: 644295:METEV_RS08340
uniprot id: D7EAZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06610
gene id: 644295:METEV_RS06610
uniprot id: D7E9B8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

644295:METEV RS00335
gene id: 644295:METEV_RS00335
uniprot id: D7E5X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

644295:METEV RS09595
gene id: 644295:METEV_RS09595
uniprot id: D7EA72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS08210
gene id: 644295:METEV_RS08210
uniprot id: D7EAX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

644295:METEV RS07265
gene id: 644295:METEV_RS07265
uniprot id: D7E9N9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS04220
gene id: 644295:METEV_RS04220
uniprot id: D7E8S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS08440
gene id: 644295:METEV_RS08440
uniprot id: D7EB13
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

644295:METEV RS02450
gene id: 644295:METEV_RS02450
uniprot id: D7E865
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

644295:METEV RS07145
gene id: 644295:METEV_RS07145
uniprot id: D7E9L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

644295:METEV RS10670
gene id: 644295:METEV_RS10670
uniprot id: D7EAF8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

644295:METEV RS03715
gene id: 644295:METEV_RS03715
uniprot id: D7E732
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

644295:METEV RS03620
gene id: 644295:METEV_RS03620
uniprot id: D7E711
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

644295:METEV RS00285
gene id: 644295:METEV_RS00285
uniprot id: D7E5W2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

644295:METEV RS05625
gene id: 644295:METEV_RS05625
uniprot id: D7E968
names: Similarity
messages: Belongs to the glutaredoxin family.

644295:METEV RS08700
gene id: 644295:METEV_RS08700
uniprot id: D7EB60
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10030
gene id: 644295:METEV_RS10030
uniprot id: D7EBI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

644295:METEV RS03845
gene id: 644295:METEV_RS03845
uniprot id: D7E754
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

644295:METEV RS06905
gene id: 644295:METEV_RS06905
uniprot id: D7E9H1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS05835
gene id: 644295:METEV_RS05835
uniprot id: D7E9A5
names: Similarity
messages: Belongs to the UPF0251 family.

644295:METEV RS00035
gene id: 644295:METEV_RS00035
uniprot id: D7E5R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

644295:METEV RS04400
gene id: 644295:METEV_RS04400
uniprot id: D7E8W3
names: Similarity
messages: Belongs to the peptidase U62 family.

644295:METEV RS09245
gene id: 644295:METEV_RS09245
uniprot id: D7EA09
names: Similarity
messages: Belongs to the AAA ATPase family.

644295:METEV RS09690
gene id: 644295:METEV_RS09690
uniprot id: D7EA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

644295:METEV RS06655
gene id: 644295:METEV_RS06655
uniprot id: D7E9C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

644295:METEV RS05085
gene id: 644295:METEV_RS05085
uniprot id: D7E7G7
names: Similarity
messages: Belongs to the HisA/HisF family.

644295:METEV RS01040
gene id: 644295:METEV_RS01040
uniprot id: D7E6B7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

644295:METEV RS04145
gene id: 644295:METEV_RS04145
uniprot id: D7E8R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS05180
gene id: 644295:METEV_RS05180
uniprot id: D7E7I4
names: Similarity
messages: Belongs to the peptidase C56 family.

644295:METEV RS02275
gene id: 644295:METEV_RS02275
uniprot id: D7E828
names: Similarity
messages: Belongs to the DNase I family.

644295:METEV RS07030
gene id: 644295:METEV_RS07030
uniprot id: D7E9J5
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS01395
gene id: 644295:METEV_RS01395
uniprot id: D7E6I6
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09965
gene id: 644295:METEV_RS09965
uniprot id: D7EBH3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

644295:METEV RS03865
gene id: 644295:METEV_RS03865
uniprot id: D7E8L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS08125
gene id: 644295:METEV_RS08125
uniprot id: D7EAV5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

644295:METEV RS10270
gene id: 644295:METEV_RS10270
uniprot id: D7EBN7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

644295:METEV RS09185
gene id: 644295:METEV_RS09185
uniprot id: D7EBF2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

644295:METEV RS11040
gene id: 644295:METEV_RS11040
uniprot id: D7EAN2
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

644295:METEV RS08420
gene id: 644295:METEV_RS08420
uniprot id: D7EB10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

644295:METEV RS10375
gene id: 644295:METEV_RS10375
uniprot id: D7EBQ6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS08435
gene id: 644295:METEV_RS08435
uniprot id: D7EB12
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

644295:METEV RS08855
gene id: 644295:METEV_RS08855
uniprot id: D7EB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

644295:METEV RS08330
gene id: 644295:METEV_RS08330
uniprot id: D7EAZ3
names: Similarity
messages: Belongs to the class-I fumarase family.

644295:METEV RS04450
gene id: 644295:METEV_RS04450
uniprot id: D7E8X3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

644295:METEV RS08370
gene id: 644295:METEV_RS08370
uniprot id: D7EB00
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04345
gene id: 644295:METEV_RS04345
uniprot id: D7E8V4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06710
gene id: 644295:METEV_RS06710
uniprot id: D7E9D5
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS07155
gene id: 644295:METEV_RS07155
uniprot id: D7E9L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

644295:METEV RS08560
gene id: 644295:METEV_RS08560
uniprot id: D7EB36
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02765
gene id: 644295:METEV_RS02765
uniprot id: D7E8C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

644295:METEV RS10535
gene id: 644295:METEV_RS10535
uniprot id: D7EAD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

644295:METEV RS11490
gene id: 644295:METEV_RS11490
uniprot id: D7EBY5
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09080
gene id: 644295:METEV_RS09080
uniprot id: D7EBD2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS01570
gene id: 644295:METEV_RS01570
uniprot id: D7E6M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

644295:METEV RS06740
gene id: 644295:METEV_RS06740
uniprot id: D7E9D9
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10865
gene id: 644295:METEV_RS10865
uniprot id: D7EAJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

644295:METEV RS04475
gene id: 644295:METEV_RS04475
uniprot id: D7E8X8
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

644295:METEV RS10040
gene id: 644295:METEV_RS10040
uniprot id: D7EBJ1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS08675
gene id: 644295:METEV_RS08675
uniprot id: D7EB55
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

644295:METEV RS01910
gene id: 644295:METEV_RS01910
uniprot id: D7E7W1
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04200
gene id: 644295:METEV_RS04200
uniprot id: D7E8S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

644295:METEV RS00030
gene id: 644295:METEV_RS00030
uniprot id: D7E5R6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

644295:METEV RS06875
gene id: 644295:METEV_RS06875
uniprot id: D7E9G4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS06895
gene id: 644295:METEV_RS06895
uniprot id: D7E9G9
names: Similarity
messages: Belongs to the AOR/FOR family.

644295:METEV RS08680
gene id: 644295:METEV_RS08680
uniprot id: D7EB56
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

644295:METEV RS07410
gene id: 644295:METEV_RS07410
uniprot id: D7E9R6
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08815
gene id: 644295:METEV_RS08815
uniprot id: D7EB80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

644295:METEV RS07895
gene id: 644295:METEV_RS07895
uniprot id: D7EAR4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06970
gene id: 644295:METEV_RS06970
uniprot id: D7E9I5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

644295:METEV RS04880
gene id: 644295:METEV_RS04880
uniprot id: D7E7D0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

644295:METEV RS00160
gene id: 644295:METEV_RS00160
uniprot id: D7E5U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

644295:METEV RS09195
gene id: 644295:METEV_RS09195
uniprot id: D7EBF4
names: Similarity
messages: Belongs to the AAA ATPase family.

644295:METEV RS04570
gene id: 644295:METEV_RS04570
uniprot id: D7E770
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS05545
gene id: 644295:METEV_RS05545
uniprot id: D7E951
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

644295:METEV RS11200
gene id: 644295:METEV_RS11200
uniprot id: D7EBT9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

644295:METEV RS00295
gene id: 644295:METEV_RS00295
uniprot id: D7E5W4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

644295:METEV RS11420
gene id: 644295:METEV_RS11420
uniprot id: D7EBX3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

644295:METEV RS00220
gene id: 644295:METEV_RS00220
uniprot id: D7E5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

644295:METEV RS09820
gene id: 644295:METEV_RS09820
uniprot id: D7EAB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

644295:METEV RS08595
gene id: 644295:METEV_RS08595
uniprot id: D7EB43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

644295:METEV RS05225
gene id: 644295:METEV_RS05225
uniprot id: D7E8Z5
names: Similarity
messages: Belongs to the UPF0280 family.

644295:METEV RS10785
gene id: 644295:METEV_RS10785
uniprot id: D7EAI1
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

644295:METEV RS06285
gene id: 644295:METEV_RS06285
uniprot id: D7E7Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

644295:METEV RS01005
gene id: 644295:METEV_RS01005
uniprot id: D7E6B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

644295:METEV RS04240
gene id: 644295:METEV_RS04240
uniprot id: D7E8T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

644295:METEV RS05255
gene id: 644295:METEV_RS05255
uniprot id: D7E901
names: Similarity
messages: Belongs to the DMRL synthase family.

644295:METEV RS05955
gene id: 644295:METEV_RS05955
uniprot id: D7E7K3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS09510
gene id: 644295:METEV_RS09510
uniprot id: D7EA56
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04930
gene id: 644295:METEV_RS04930
uniprot id: D7E7D8
names: Subcellular Location Annotation
messages: Cytoplasm

644295:METEV RS03420
gene id: 644295:METEV_RS03420
uniprot id: D7E6X2
names: Similarity
messages: Belongs to the peptidase C56 family.

644295:METEV RS00405
gene id: 644295:METEV_RS00405
uniprot id: D7E5Y6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS06500
gene id: 644295:METEV_RS06500
uniprot id: D7E7U5
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04565
gene id: 644295:METEV_RS04565
uniprot id: D7E769
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08130
gene id: 644295:METEV_RS08130
uniprot id: D7EAV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

644295:METEV RS06940
gene id: 644295:METEV_RS06940
uniprot id: D7E9H9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS10185
gene id: 644295:METEV_RS10185
uniprot id: D7EBM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

644295:METEV RS06510
gene id: 644295:METEV_RS06510
uniprot id: D7E7U7
names: Similarity
messages: Belongs to the DtxR/MntR family.

644295:METEV RS05485
gene id: 644295:METEV_RS05485
uniprot id: D7E939
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

644295:METEV RS06750
gene id: 644295:METEV_RS06750
uniprot id: D7E9E1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

644295:METEV RS07765
gene id: 644295:METEV_RS07765
uniprot id: D7E9Y5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS05590
gene id: 644295:METEV_RS05590
uniprot id: D7E960
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

644295:METEV RS07345
gene id: 644295:METEV_RS07345
uniprot id: D7E9Q3
names: Similarity
messages: Belongs to the HdrB family.

644295:METEV RS01170
gene id: 644295:METEV_RS01170
uniprot id: D7E6E4
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

644295:METEV RS04215
gene id: 644295:METEV_RS04215
uniprot id: D7E8S8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

644295:METEV RS02145
gene id: 644295:METEV_RS02145
uniprot id: D7E805
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08390
gene id: 644295:METEV_RS08390
uniprot id: D7EB04
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

644295:METEV RS00490
gene id: 644295:METEV_RS00490
uniprot id: D7E603
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

644295:METEV RS04110
gene id: 644295:METEV_RS04110
uniprot id: D7E8Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

644295:METEV RS00540
gene id: 644295:METEV_RS00540
uniprot id: D7E613
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

644295:METEV RS05880
gene id: 644295:METEV_RS05880
uniprot id: D7E7I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS00500
gene id: 644295:METEV_RS00500
uniprot id: D7E605
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

644295:METEV RS06320
gene id: 644295:METEV_RS06320
uniprot id: D7E7R5
names: Similarity
messages: Belongs to the DtxR/MntR family.

644295:METEV RS10155
gene id: 644295:METEV_RS10155
uniprot id: D7EBL4
names: Similarity
messages: Belongs to the aspartokinase family.

644295:METEV RS11245
gene id: 644295:METEV_RS11245
uniprot id: D7EBU3
names: Similarity
messages: Belongs to the peptidase S49 family.

644295:METEV RS07580
gene id: 644295:METEV_RS07580
uniprot id: D7E9V0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

644295:METEV RS03575
gene id: 644295:METEV_RS03575
uniprot id: D7E702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

644295:METEV RS06360
gene id: 644295:METEV_RS06360
uniprot id: D7E7S1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS05070
gene id: 644295:METEV_RS05070
uniprot id: D7E7G5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

644295:METEV RS09020
gene id: 644295:METEV_RS09020
uniprot id: D7EBC0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS02905
gene id: 644295:METEV_RS02905
uniprot id: D7E8F0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

644295:METEV RS01580
gene id: 644295:METEV_RS01580
uniprot id: D7E6M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS00720
gene id: 644295:METEV_RS00720
uniprot id: D7E649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

644295:METEV RS06825
gene id: 644295:METEV_RS06825
uniprot id: D7E9F7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

644295:METEV RS07690
gene id: 644295:METEV_RS07690
uniprot id: D7E9X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

644295:METEV RS10895
gene id: 644295:METEV_RS10895
uniprot id: D7EAK4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

644295:METEV RS06945
gene id: 644295:METEV_RS06945
uniprot id: D7E9I0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

644295:METEV RS10455
gene id: 644295:METEV_RS10455
uniprot id: D7EBS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS07695
gene id: 644295:METEV_RS07695
uniprot id: D7E9X2
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

644295:METEV RS05675
gene id: 644295:METEV_RS05675
uniprot id: D7E977
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS07105
gene id: 644295:METEV_RS07105
uniprot id: D7E9K9
names: Similarity
messages: Belongs to the UPF0305 family.

644295:METEV RS03830
gene id: 644295:METEV_RS03830
uniprot id: D7E751
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

644295:METEV RS08640
gene id: 644295:METEV_RS08640
uniprot id: D7EB53
names: Subcellular Location Annotation
messages: Cell membrane

644295:METEV RS10235
gene id: 644295:METEV_RS10235
uniprot id: D7EBN0
names: Similarity
messages: Belongs to the UPF0047 family.

644295:METEV RS10195
gene id: 644295:METEV_RS10195
uniprot id: D7EBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

644295:METEV RS04620
gene id: 644295:METEV_RS04620
uniprot id: D7E779
names: Similarity
messages: Belongs to the AdoMet synthase family.

644295:METEV RS02070
gene id: 644295:METEV_RS02070
uniprot id: D7E7Z0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

644295:METEV RS05520
gene id: 644295:METEV_RS05520
uniprot id: D7E946
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS09155
gene id: 644295:METEV_RS09155
uniprot id: D7EBE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

644295:METEV RS11105
gene id: 644295:METEV_RS11105
uniprot id: D7EAP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

644295:METEV RS10845
gene id: 644295:METEV_RS10845
uniprot id: D7EAJ3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

644295:METEV RS00310
gene id: 644295:METEV_RS00310
uniprot id: D7E5W7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

644295:METEV RS08285
gene id: 644295:METEV_RS08285
uniprot id: D7EAY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

644295:METEV RS04875
gene id: 644295:METEV_RS04875
uniprot id: D7E7C9
names: Similarity
messages: Belongs to the peptidase S1C family.

644295:METEV RS07905
gene id: 644295:METEV_RS07905
uniprot id: D7EAR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

644295:METEV RS11030
gene id: 644295:METEV_RS11030
uniprot id: D7EAN0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS01990
gene id: 644295:METEV_RS01990
uniprot id: D7E7X5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

644295:METEV RS11045
gene id: 644295:METEV_RS11045
uniprot id: D7EAN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

644295:METEV RS07110
gene id: 644295:METEV_RS07110
uniprot id: D7E9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

644295:METEV RS03440
gene id: 644295:METEV_RS03440
uniprot id: D7E6X7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

644295:METEV RS01035
gene id: 644295:METEV_RS01035
uniprot id: D7E6B6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS05155
gene id: 644295:METEV_RS05155
uniprot id: D7E7I2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

644295:METEV RS06925
gene id: 644295:METEV_RS06925
uniprot id: D7E9H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

644295:METEV RS03875
gene id: 644295:METEV_RS03875
uniprot id: D7E8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS08475
gene id: 644295:METEV_RS08475
uniprot id: D7EB20
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

644295:METEV RS02110
gene id: 644295:METEV_RS02110
uniprot id: D7E7Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

644295:METEV RS01140
gene id: 644295:METEV_RS01140
uniprot id: D7E6D8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

644295:METEV RS10630
gene id: 644295:METEV_RS10630
uniprot id: D7EAF0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS01180
gene id: 644295:METEV_RS01180
uniprot id: D7E6E6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

644295:METEV RS02170
gene id: 644295:METEV_RS02170
uniprot id: D7E810
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS02570
gene id: 644295:METEV_RS02570
uniprot id: D7E885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

644295:METEV RS03015
gene id: 644295:METEV_RS03015
uniprot id: D7E8H1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

644295:METEV RS04235
gene id: 644295:METEV_RS04235
uniprot id: D7E8T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

644295:METEV RS06955
gene id: 644295:METEV_RS06955
uniprot id: D7E9I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

644295:METEV RS10540
gene id: 644295:METEV_RS10540
uniprot id: D7EAD2
names: Similarity
messages: Belongs to the peptidase M24B family.

644295:METEV RS03635
gene id: 644295:METEV_RS03635
uniprot id: D7E715
names: Similarity
messages: Belongs to the PDCD5 family.

644295:METEV RS10280
gene id: 644295:METEV_RS10280
uniprot id: D7EBP0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09305
gene id: 644295:METEV_RS09305
uniprot id: D7EA20
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

644295:METEV RS06725
gene id: 644295:METEV_RS06725
uniprot id: D7E9D7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS09120
gene id: 644295:METEV_RS09120
uniprot id: D7EBE0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS11025
gene id: 644295:METEV_RS11025
uniprot id: D7EAM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

644295:METEV RS08525
gene id: 644295:METEV_RS08525
uniprot id: D7EB29
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

644295:METEV RS05345
gene id: 644295:METEV_RS05345
uniprot id: D7E917
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

644295:METEV RS04340
gene id: 644295:METEV_RS04340
uniprot id: D7E8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

644295:METEV RS02470
gene id: 644295:METEV_RS02470
uniprot id: D7E869
names: Similarity
messages: Belongs to the UPF0166 family.

644295:METEV RS05885
gene id: 644295:METEV_RS05885
uniprot id: D7E7I9
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS00915
gene id: 644295:METEV_RS00915
uniprot id: D7E694
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

644295:METEV RS04190
gene id: 644295:METEV_RS04190
uniprot id: D7E8S3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

644295:METEV RS05405
gene id: 644295:METEV_RS05405
uniprot id: D7E926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

644295:METEV RS09910
gene id: 644295:METEV_RS09910
uniprot id: D7EBG4
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

644295:METEV RS09500
gene id: 644295:METEV_RS09500
uniprot id: D7EA54
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS05495
gene id: 644295:METEV_RS05495
uniprot id: D7E941
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS09580
gene id: 644295:METEV_RS09580
uniprot id: D7EA69
names: Subcellular Location Annotation
messages: Cytoplasm

644295:METEV RS11315
gene id: 644295:METEV_RS11315
uniprot id: D7EBV6
names: Subcellular Location Annotation
messages: Cell membrane

644295:METEV RS11385
gene id: 644295:METEV_RS11385
uniprot id: D7EBW6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS09680
gene id: 644295:METEV_RS09680
uniprot id: D7EA90
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

644295:METEV RS02525
gene id: 644295:METEV_RS02525
uniprot id: D7E879
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

644295:METEV RS00255
gene id: 644295:METEV_RS00255
uniprot id: D7E5V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

644295:METEV RS08935
gene id: 644295:METEV_RS08935
uniprot id: D7EBA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

644295:METEV RS00950
gene id: 644295:METEV_RS00950
uniprot id: D7E699
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

644295:METEV RS11425
gene id: 644295:METEV_RS11425
uniprot id: D7EBX4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS08020
gene id: 644295:METEV_RS08020
uniprot id: D7EAT7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

644295:METEV RS00480
gene id: 644295:METEV_RS00480
uniprot id: D7E601
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

644295:METEV RS09520
gene id: 644295:METEV_RS09520
uniprot id: D7EA58
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS09330
gene id: 644295:METEV_RS09330
uniprot id: D7EA24
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10190
gene id: 644295:METEV_RS10190
uniprot id: D7EBM1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

644295:METEV RS03930
gene id: 644295:METEV_RS03930
uniprot id: D7E8M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

644295:METEV RS03815
gene id: 644295:METEV_RS03815
uniprot id: D7E748
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

644295:METEV RS01285
gene id: 644295:METEV_RS01285
uniprot id: D7E6G4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

644295:METEV RS07415
gene id: 644295:METEV_RS07415
uniprot id: D7E9R7
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS06885
gene id: 644295:METEV_RS06885
uniprot id: D7E9G7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10180
gene id: 644295:METEV_RS10180
uniprot id: D7EBL9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

644295:METEV RS11340
gene id: 644295:METEV_RS11340
uniprot id: D7EBV9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

644295:METEV RS10590
gene id: 644295:METEV_RS10590
uniprot id: D7EAE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

644295:METEV RS04675
gene id: 644295:METEV_RS04675
uniprot id: D7E790
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS08860
gene id: 644295:METEV_RS08860
uniprot id: D7EB89
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

644295:METEV RS07880
gene id: 644295:METEV_RS07880
uniprot id: D7EAR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

644295:METEV RS10575
gene id: 644295:METEV_RS10575
uniprot id: D7EAD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

644295:METEV RS01535
gene id: 644295:METEV_RS01535
uniprot id: D7E6L3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

644295:METEV RS09465
gene id: 644295:METEV_RS09465
uniprot id: D7EA46
names: Similarity
messages: Belongs to the AOR/FOR family.

644295:METEV RS09040
gene id: 644295:METEV_RS09040
uniprot id: D7EBC4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

644295:METEV RS08260
gene id: 644295:METEV_RS08260
uniprot id: D7EAY0
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08170
gene id: 644295:METEV_RS08170
uniprot id: D7EAW2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS02790
gene id: 644295:METEV_RS02790
uniprot id: D7E8C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

644295:METEV RS00330
gene id: 644295:METEV_RS00330
uniprot id: D7E5X1
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

644295:METEV RS03090
gene id: 644295:METEV_RS03090
uniprot id: D7E8I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

644295:METEV RS09225
gene id: 644295:METEV_RS09225
uniprot id: D7EA05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

644295:METEV RS05585
gene id: 644295:METEV_RS05585
uniprot id: D7E959
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

644295:METEV RS07320
gene id: 644295:METEV_RS07320
uniprot id: D7E9P8
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

644295:METEV RS01490
gene id: 644295:METEV_RS01490
uniprot id: D7E6K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

644295:METEV RS05015
gene id: 644295:METEV_RS05015
uniprot id: D7E7F4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS10330
gene id: 644295:METEV_RS10330
uniprot id: D7EBP8
names: Subunit
messages: Homotetramer.

644295:METEV RS10390
gene id: 644295:METEV_RS10390
uniprot id: D7EBQ8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

644295:METEV RS01155
gene id: 644295:METEV_RS01155
uniprot id: D7E6E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

644295:METEV RS09935
gene id: 644295:METEV_RS09935
uniprot id: D7EBG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

644295:METEV RS09835
gene id: 644295:METEV_RS09835
uniprot id: D7EAC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

644295:METEV RS04920
gene id: 644295:METEV_RS04920
uniprot id: D7E7D6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

644295:METEV RS02770
gene id: 644295:METEV_RS02770
uniprot id: D7E8C3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

644295:METEV RS02665
gene id: 644295:METEV_RS02665
uniprot id: D7E8A4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

644295:METEV RS08015
gene id: 644295:METEV_RS08015
uniprot id: D7EAT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

644295:METEV RS10990
gene id: 644295:METEV_RS10990
uniprot id: D7EAM3
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS00620
gene id: 644295:METEV_RS00620
uniprot id: D7E628
names: Similarity
messages: Belongs to the UPF0292 family.

644295:METEV RS05250
gene id: 644295:METEV_RS05250
uniprot id: D7E900
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

644295:METEV RS05275
gene id: 644295:METEV_RS05275
uniprot id: D7E905
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

644295:METEV RS11380
gene id: 644295:METEV_RS11380
uniprot id: D7EBW5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS02180
gene id: 644295:METEV_RS02180
uniprot id: D7E812
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

644295:METEV RS04165
gene id: 644295:METEV_RS04165
uniprot id: D7E8R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS05000
gene id: 644295:METEV_RS05000
uniprot id: D7E7F1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

644295:METEV RS02080
gene id: 644295:METEV_RS02080
uniprot id: D7E7Z2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

644295:METEV RS03860
gene id: 644295:METEV_RS03860
uniprot id: D7E757
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS06775
gene id: 644295:METEV_RS06775
uniprot id: D7E9E6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

644295:METEV RS04560
gene id: 644295:METEV_RS04560
uniprot id: D7E768
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

644295:METEV RS06620
gene id: 644295:METEV_RS06620
uniprot id: D7E9C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

644295:METEV RS00320
gene id: 644295:METEV_RS00320
uniprot id: D7E5W9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

644295:METEV RS05060
gene id: 644295:METEV_RS05060
uniprot id: D7E7G3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS10610
gene id: 644295:METEV_RS10610
uniprot id: D7EAE6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

644295:METEV RS03895
gene id: 644295:METEV_RS03895
uniprot id: D7E8L6
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

644295:METEV RS02755
gene id: 644295:METEV_RS02755
uniprot id: D7E8C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

644295:METEV RS02130
gene id: 644295:METEV_RS02130
uniprot id: D7E802
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

644295:METEV RS02325
gene id: 644295:METEV_RS02325
uniprot id: D7E838
names: Similarity
messages: Belongs to the HsdR family.

644295:METEV RS05065
gene id: 644295:METEV_RS05065
uniprot id: D7E7G4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS02320
gene id: 644295:METEV_RS02320
uniprot id: D7E837
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

644295:METEV RS04270
gene id: 644295:METEV_RS04270
uniprot id: D7E8T9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS10705
gene id: 644295:METEV_RS10705
uniprot id: D7EAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

644295:METEV RS09860
gene id: 644295:METEV_RS09860
uniprot id: D7EAC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

644295:METEV RS01610
gene id: 644295:METEV_RS01610
uniprot id: D7E6M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

644295:METEV RS01510
gene id: 644295:METEV_RS01510
uniprot id: D7E6K8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

644295:METEV RS03640
gene id: 644295:METEV_RS03640
uniprot id: D7E716
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS02025
gene id: 644295:METEV_RS02025
uniprot id: D7E7Y1
names: Similarity
messages: Belongs to the AAA ATPase family.

644295:METEV RS01100
gene id: 644295:METEV_RS01100
uniprot id: D7E6D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

644295:METEV RS07875
gene id: 644295:METEV_RS07875
uniprot id: D7EAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

644295:METEV RS00215
gene id: 644295:METEV_RS00215
uniprot id: D7E5V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

644295:METEV RS02845
gene id: 644295:METEV_RS02845
uniprot id: D7E8D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

644295:METEV RS03820
gene id: 644295:METEV_RS03820
uniprot id: D7E749
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

644295:METEV RS05500
gene id: 644295:METEV_RS05500
uniprot id: D7E942
names: Cofactor
messages: Binds 1 zinc ion per subunit.

644295:METEV RS02620
gene id: 644295:METEV_RS02620
uniprot id: D7E895
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

644295:METEV RS05505
gene id: 644295:METEV_RS05505
uniprot id: D7E943
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

644295:METEV RS07200
gene id: 644295:METEV_RS07200
uniprot id: D7E9M6
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

644295:METEV RS10110
gene id: 644295:METEV_RS10110
uniprot id: D7EBK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

644295:METEV RS08115
gene id: 644295:METEV_RS08115
uniprot id: D7EAV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

644295:METEV RS01780
gene id: 644295:METEV_RS01780
uniprot id: D7E6Q7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

644295:METEV RS11645
gene id: 644295:METEV_RS11645
uniprot id: D7EC14
names: Similarity
messages: Belongs to the UPF0228 family.

644295:METEV RS07680
gene id: 644295:METEV_RS07680
uniprot id: D7E9W9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

644295:METEV RS09300
gene id: 644295:METEV_RS09300
uniprot id: D7EA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

644295:METEV RS03695
gene id: 644295:METEV_RS03695
uniprot id: D7E727
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

644295:METEV RS00145
gene id: 644295:METEV_RS00145
uniprot id: D7E5T9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS06935
gene id: 644295:METEV_RS06935
uniprot id: D7E9H8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

644295:METEV RS07180
gene id: 644295:METEV_RS07180
uniprot id: D7E9M2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS03365
gene id: 644295:METEV_RS03365
uniprot id: D7E6W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

644295:METEV RS05040
gene id: 644295:METEV_RS05040
uniprot id: D7E7F9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

644295:METEV RS07900
gene id: 644295:METEV_RS07900
uniprot id: D7EAR5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

644295:METEV RS07015
gene id: 644295:METEV_RS07015
uniprot id: D7E9J2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

644295:METEV RS01350
gene id: 644295:METEV_RS01350
uniprot id: D7E6H7
names: Similarity
messages: Belongs to the complex I subunit 3 family.

644295:METEV RS05020
gene id: 644295:METEV_RS05020
uniprot id: D7E7F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

644295:METEV RS09640
gene id: 644295:METEV_RS09640
uniprot id: D7EA83
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04095
gene id: 644295:METEV_RS04095
uniprot id: D7E8Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

644295:METEV RS07445
gene id: 644295:METEV_RS07445
uniprot id: D7E9S3
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS01565
gene id: 644295:METEV_RS01565
uniprot id: D7E6L9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

644295:METEV RS08355
gene id: 644295:METEV_RS08355
uniprot id: D7EAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

644295:METEV RS00175
gene id: 644295:METEV_RS00175
uniprot id: D7E5U5
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

644295:METEV RS02555
gene id: 644295:METEV_RS02555
uniprot id: D7E884
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

644295:METEV RS07630
gene id: 644295:METEV_RS07630
uniprot id: D7E9W0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

644295:METEV RS09725
gene id: 644295:METEV_RS09725
uniprot id: D7EA99
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

644295:METEV RS11250
gene id: 644295:METEV_RS11250
uniprot id: D7EBU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

644295:METEV RS02850
gene id: 644295:METEV_RS02850
uniprot id: D7E8D9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

644295:METEV RS04225
gene id: 644295:METEV_RS04225
uniprot id: D7E8T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

644295:METEV RS11410
gene id: 644295:METEV_RS11410
uniprot id: D7EBX1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

644295:METEV RS04265
gene id: 644295:METEV_RS04265
uniprot id: D7E8T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

644295:METEV RS04365
gene id: 644295:METEV_RS04365
uniprot id: D7E8V7
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

644295:METEV RS03675
gene id: 644295:METEV_RS03675
uniprot id: D7E723
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS07660
gene id: 644295:METEV_RS07660
uniprot id: D7E9W5
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

644295:METEV RS05190
gene id: 644295:METEV_RS05190
uniprot id: D7E8Y7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS06915
gene id: 644295:METEV_RS06915
uniprot id: D7E9H3
names: Similarity
messages: Belongs to the MtxX family.

644295:METEV RS11165
gene id: 644295:METEV_RS11165
uniprot id: D7EAQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS08620
gene id: 644295:METEV_RS08620
uniprot id: D7EB49
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

644295:METEV RS10725
gene id: 644295:METEV_RS10725
uniprot id: D7EAG9
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

644295:METEV RS10035
gene id: 644295:METEV_RS10035
uniprot id: D7EBJ0
names: Similarity
messages: Belongs to the TrpF family.

644295:METEV RS04665
gene id: 644295:METEV_RS04665
uniprot id: D7E788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

644295:METEV RS04395
gene id: 644295:METEV_RS04395
uniprot id: D7E8W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

644295:METEV RS09760
gene id: 644295:METEV_RS09760
uniprot id: D7EAA5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

644295:METEV RS05150
gene id: 644295:METEV_RS05150
uniprot id: D7E7I1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

644295:METEV RS02535
gene id: 644295:METEV_RS02535
uniprot id: D7E881
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS04470
gene id: 644295:METEV_RS04470
uniprot id: D7E8X7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

644295:METEV RS02140
gene id: 644295:METEV_RS02140
uniprot id: D7E804
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS04160
gene id: 644295:METEV_RS04160
uniprot id: D7E8R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

644295:METEV RS04245
gene id: 644295:METEV_RS04245
uniprot id: D7E8T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

644295:METEV RS12290
gene id: 644295:METEV_RS12290
uniprot id: D7E6Y6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

644295:METEV RS02430
gene id: 644295:METEV_RS02430
uniprot id: D7E861
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

644295:METEV RS09325
gene id: 644295:METEV_RS09325
uniprot id: D7EA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

644295:METEV RS10450
gene id: 644295:METEV_RS10450
uniprot id: D7EBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

644295:METEV RS06125
gene id: 644295:METEV_RS06125
uniprot id: D7E7N4
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS05045
gene id: 644295:METEV_RS05045
uniprot id: D7E7G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

644295:METEV RS01280
gene id: 644295:METEV_RS01280
uniprot id: D7E6G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

644295:METEV RS02045
gene id: 644295:METEV_RS02045
uniprot id: D7E7Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

644295:METEV RS02120
gene id: 644295:METEV_RS02120
uniprot id: D7E800
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

644295:METEV RS09915
gene id: 644295:METEV_RS09915
uniprot id: D7EBG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

644295:METEV RS05720
gene id: 644295:METEV_RS05720
uniprot id: D7E986
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

644295:METEV RS07195
gene id: 644295:METEV_RS07195
uniprot id: D7E9M5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

644295:METEV RS04275
gene id: 644295:METEV_RS04275
uniprot id: D7E8U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

644295:METEV RS04120
gene id: 644295:METEV_RS04120
uniprot id: D7E8Q8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

644295:METEV RS07570
gene id: 644295:METEV_RS07570
uniprot id: D7E9U8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

644295:METEV RS01865
gene id: 644295:METEV_RS01865
uniprot id: D7E6S3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

644295:METEV RS00440
gene id: 644295:METEV_RS00440
uniprot id: D7E5Z3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS09985
gene id: 644295:METEV_RS09985
uniprot id: D7EBH7
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS09140
gene id: 644295:METEV_RS09140
uniprot id: D7EBE4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

644295:METEV RS03685
gene id: 644295:METEV_RS03685
uniprot id: D7E725
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

644295:METEV RS07930
gene id: 644295:METEV_RS07930
uniprot id: D7EAS1
names: Subcellular Location Annotation
messages: Membrane

644295:METEV RS08455
gene id: 644295:METEV_RS08455
uniprot id: D7EB16
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

644295:METEV RS04125
gene id: 644295:METEV_RS04125
uniprot id: D7E8Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

644295:METEV RS00865
gene id: 644295:METEV_RS00865
uniprot id: D7E681
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

644295:METEV RS01160
gene id: 644295:METEV_RS01160
uniprot id: D7E6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

644295:METEV RS05525
gene id: 644295:METEV_RS05525
uniprot id: D7E947
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

644295:METEV RS02975
gene id: 644295:METEV_RS02975
uniprot id: D7E8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

644295:METEV RS04105
gene id: 644295:METEV_RS04105
uniprot id: D7E8Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

644295:METEV RS09745
gene id: 644295:METEV_RS09745
uniprot id: D7EAA3
names: Function
messages: Part of a potassium transport system.

644295:METEV RS11590
gene id: 644295:METEV_RS11590
uniprot id: D7EC02
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.