637390:GCD22 RS16805
gene id: 637390:GCD22_RS16805
uniprot id: A0A5P9XVL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS01060
gene id: 637390:GCD22_RS01060
uniprot id: A0A543Q0G2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05855
gene id: 637390:GCD22_RS05855
uniprot id: A0A5P9XP99
names: Similarity
messages: Belongs to the bacterial flagellin family.

637390:GCD22 RS01260
gene id: 637390:GCD22_RS01260
uniprot id: A0A5P9XME1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

637390:GCD22 RS00015
gene id: 637390:GCD22_RS00015
uniprot id: A0A5P9XN53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

637390:GCD22 RS09990
gene id: 637390:GCD22_RS09990
uniprot id: A0A5P9XRF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

637390:GCD22 RS01420
gene id: 637390:GCD22_RS01420
uniprot id: A0A5P9XLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

637390:GCD22 RS00010
gene id: 637390:GCD22_RS00010
uniprot id: A0A5P9XKP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

637390:GCD22 RS17175
gene id: 637390:GCD22_RS17175
uniprot id: A0A5P9XVW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

637390:GCD22 RS01375
gene id: 637390:GCD22_RS01375
uniprot id: A0A543Q0M4
names: Caution
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS00545
gene id: 637390:GCD22_RS00545
uniprot id: A0A5P9XL26
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

637390:GCD22 RS16830
gene id: 637390:GCD22_RS16830
uniprot id: A0A543Q676
names: Caution
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS17590
gene id: 637390:GCD22_RS17590
uniprot id: A0A543Q6W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS02220
gene id: 637390:GCD22_RS02220
uniprot id: A0A5P9XMW3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

637390:GCD22 RS16005
gene id: 637390:GCD22_RS16005
uniprot id: A0A5P9XUI2
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS05640
gene id: 637390:GCD22_RS05640
uniprot id: A0A543Q7N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS00220
gene id: 637390:GCD22_RS00220
uniprot id: A0A5P9XKV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

637390:GCD22 RS06325
gene id: 637390:GCD22_RS06325
uniprot id: A0A5P9XRB7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS11070
gene id: 637390:GCD22_RS11070
uniprot id: A0A5P9XRC6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS13620
gene id: 637390:GCD22_RS13620
uniprot id: A0A5P9XT79
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS02870
gene id: 637390:GCD22_RS02870
uniprot id: A0A5P9XN64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS04780
gene id: 637390:GCD22_RS04780
uniprot id: A0A5P9XN47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

637390:GCD22 RS05150
gene id: 637390:GCD22_RS05150
uniprot id: A0A5P9XQ37
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

637390:GCD22 RS15485
gene id: 637390:GCD22_RS15485
uniprot id: A0A5P9XTI3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

637390:GCD22 RS02060
gene id: 637390:GCD22_RS02060
uniprot id: A0A5P9XP83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

637390:GCD22 RS10360
gene id: 637390:GCD22_RS10360
uniprot id: A0A543Q2T2
names: Caution
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS11340
gene id: 637390:GCD22_RS11340
uniprot id: A0A5P9XSP5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

637390:GCD22 RS12345
gene id: 637390:GCD22_RS12345
uniprot id: A0A5P9XSJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

637390:GCD22 RS02160
gene id: 637390:GCD22_RS02160
uniprot id: A0A5P9XMV3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS06695
gene id: 637390:GCD22_RS06695
uniprot id: A0A5P9XP60
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

637390:GCD22 RS16490
gene id: 637390:GCD22_RS16490
uniprot id: A0A543Q5U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS12320
gene id: 637390:GCD22_RS12320
uniprot id: A0A543Q3P3
names: Similarity
messages: Belongs to the UPF0145 family.

637390:GCD22 RS14520
gene id: 637390:GCD22_RS14520
uniprot id: A0A5P9XTW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

637390:GCD22 RS10015
gene id: 637390:GCD22_RS10015
uniprot id: A0A543Q2K4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

637390:GCD22 RS04820
gene id: 637390:GCD22_RS04820
uniprot id: A0A5P9XNR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

637390:GCD22 RS08900
gene id: 637390:GCD22_RS08900
uniprot id: A0A5P9XRD0
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

637390:GCD22 RS16030
gene id: 637390:GCD22_RS16030
uniprot id: A0A5P9XW63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

637390:GCD22 RS14580
gene id: 637390:GCD22_RS14580
uniprot id: A0A5P9XU91
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

637390:GCD22 RS06100
gene id: 637390:GCD22_RS06100
uniprot id: A0A0M4AYB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

637390:GCD22 RS00255
gene id: 637390:GCD22_RS00255
uniprot id: A0A543Q771
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

637390:GCD22 RS11355
gene id: 637390:GCD22_RS11355
uniprot id: A0A5P9XRZ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS02570
gene id: 637390:GCD22_RS02570
uniprot id: A0A543Q195
names: Similarity
messages: Belongs to the P(II) protein family.

637390:GCD22 RS02020
gene id: 637390:GCD22_RS02020
uniprot id: A0A543Q0Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

637390:GCD22 RS17180
gene id: 637390:GCD22_RS17180
uniprot id: A0A5P9XUG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

637390:GCD22 RS09735
gene id: 637390:GCD22_RS09735
uniprot id: A0A5P9XR32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

637390:GCD22 RS05060
gene id: 637390:GCD22_RS05060
uniprot id: A0A5P9XNV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

637390:GCD22 RS12985
gene id: 637390:GCD22_RS12985
uniprot id: A0A543Q3S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

637390:GCD22 RS09920
gene id: 637390:GCD22_RS09920
uniprot id: A0A5P9XQP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

637390:GCD22 RS01885
gene id: 637390:GCD22_RS01885
uniprot id: A0A543Q0V6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

637390:GCD22 RS16625
gene id: 637390:GCD22_RS16625
uniprot id: A0A5P9XV17
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

637390:GCD22 RS02285
gene id: 637390:GCD22_RS02285
uniprot id: A0A5P9XPB9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS00245
gene id: 637390:GCD22_RS00245
uniprot id: A0A543Q768
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

637390:GCD22 RS14860
gene id: 637390:GCD22_RS14860
uniprot id: A0A543Q4X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

637390:GCD22 RS05900
gene id: 637390:GCD22_RS05900
uniprot id: A0A5P9XNN2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

637390:GCD22 RS09650
gene id: 637390:GCD22_RS09650
uniprot id: A0A5P9XSZ1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS01440
gene id: 637390:GCD22_RS01440
uniprot id: A0A5P9XMC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

637390:GCD22 RS00060
gene id: 637390:GCD22_RS00060
uniprot id: A0A5P9XKR3
names: Similarity
messages: Belongs to the Smg family.

637390:GCD22 RS06675
gene id: 637390:GCD22_RS06675
uniprot id: A0A5P9XP56
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17230
gene id: 637390:GCD22_RS17230
uniprot id: A0A5P9XVX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

637390:GCD22 RS06415
gene id: 637390:GCD22_RS06415
uniprot id: A0A5P9XP80
names: Similarity
messages: Belongs to the bacterial phospholipase C family.

637390:GCD22 RS04715
gene id: 637390:GCD22_RS04715
uniprot id: A0A5P9XNX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

637390:GCD22 RS02250
gene id: 637390:GCD22_RS02250
uniprot id: A0A5P9XMQ9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

637390:GCD22 RS17440
gene id: 637390:GCD22_RS17440
uniprot id: A0A5P9XVY3
names: Subcellular Location Annotation
messages: Cytoplasm

637390:GCD22 RS16245
gene id: 637390:GCD22_RS16245
uniprot id: A0A5P9XW99
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

637390:GCD22 RS15335
gene id: 637390:GCD22_RS15335
uniprot id: A0A5P9XUM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

637390:GCD22 RS14635
gene id: 637390:GCD22_RS14635
uniprot id: A0A5P9XT57
names: Similarity
messages: Belongs to the histone deacetylase family.

637390:GCD22 RS02840
gene id: 637390:GCD22_RS02840
uniprot id: A0A543Q1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

637390:GCD22 RS10165
gene id: 637390:GCD22_RS10165
uniprot id: A0A543Q2N3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

637390:GCD22 RS16285
gene id: 637390:GCD22_RS16285
uniprot id: A0A543Q5Y8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

637390:GCD22 RS14425
gene id: 637390:GCD22_RS14425
uniprot id: A0A5P9XU47
names: Similarity
messages: Belongs to the thioredoxin family.

637390:GCD22 RS05040
gene id: 637390:GCD22_RS05040
uniprot id: A0A543Q7D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

637390:GCD22 RS16440
gene id: 637390:GCD22_RS16440
uniprot id: A0A5P9XU36
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

637390:GCD22 RS03685
gene id: 637390:GCD22_RS03685
uniprot id: A0A543PYZ9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04005
gene id: 637390:GCD22_RS04005
uniprot id: A0A5P9XMQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

637390:GCD22 RS16545
gene id: 637390:GCD22_RS16545
uniprot id: A0A5P9XW30
names: Similarity
messages: Belongs to the FrhG family.

637390:GCD22 RS09635
gene id: 637390:GCD22_RS09635
uniprot id: A0A5P9XSC5
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13450
gene id: 637390:GCD22_RS13450
uniprot id: A0A543Q457
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

637390:GCD22 RS12980
gene id: 637390:GCD22_RS12980
uniprot id: A0A5P9XT20
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

637390:GCD22 RS04885
gene id: 637390:GCD22_RS04885
uniprot id: A0A5P9XP21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

637390:GCD22 RS16295
gene id: 637390:GCD22_RS16295
uniprot id: A0A5P9XWA9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

637390:GCD22 RS05785
gene id: 637390:GCD22_RS05785
uniprot id: A0A543Q7Q5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

637390:GCD22 RS10060
gene id: 637390:GCD22_RS10060
uniprot id: A0A5P9XR93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS17720
gene id: 637390:GCD22_RS17720
uniprot id: A0A543Q702
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS08740
gene id: 637390:GCD22_RS08740
uniprot id: A0A543Q1Y2
names: Caution
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS10030
gene id: 637390:GCD22_RS10030
uniprot id: A0A543Q2M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

637390:GCD22 RS05415
gene id: 637390:GCD22_RS05415
uniprot id: A0A543Q7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

637390:GCD22 RS03840
gene id: 637390:GCD22_RS03840
uniprot id: A0A5P9XMM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

637390:GCD22 RS15355
gene id: 637390:GCD22_RS15355
uniprot id: A0A5P9XUZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

637390:GCD22 RS11330
gene id: 637390:GCD22_RS11330
uniprot id: A0A543Q3G7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

637390:GCD22 RS02275
gene id: 637390:GCD22_RS02275
uniprot id: A0A5P9XMX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

637390:GCD22 RS00890
gene id: 637390:GCD22_RS00890
uniprot id: A0A543Q0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

637390:GCD22 RS11585
gene id: 637390:GCD22_RS11585
uniprot id: A0A5P9XRL6
names: Similarity
messages: Belongs to the GSP E family.

637390:GCD22 RS05580
gene id: 637390:GCD22_RS05580
uniprot id: A0A5P9XNJ3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

637390:GCD22 RS00935
gene id: 637390:GCD22_RS00935
uniprot id: A0A5P9XM71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS02565
gene id: 637390:GCD22_RS02565
uniprot id: A0A5P9XM22
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS09705
gene id: 637390:GCD22_RS09705
uniprot id: A0A5P9XQG8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

637390:GCD22 RS00670
gene id: 637390:GCD22_RS00670
uniprot id: A0A5P9XM13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

637390:GCD22 RS15265
gene id: 637390:GCD22_RS15265
uniprot id: A0A5P9XVS6
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

637390:GCD22 RS04755
gene id: 637390:GCD22_RS04755
uniprot id: A0A543Q048
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS16065
gene id: 637390:GCD22_RS16065
uniprot id: A0A543Q5Q6
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

637390:GCD22 RS15960
gene id: 637390:GCD22_RS15960
uniprot id: A0A543Q5N1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

637390:GCD22 RS11595
gene id: 637390:GCD22_RS11595
uniprot id: A0A5P9XTH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

637390:GCD22 RS17130
gene id: 637390:GCD22_RS17130
uniprot id: A0A5P9XUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).

637390:GCD22 RS02125
gene id: 637390:GCD22_RS02125
uniprot id: A0A543Q114
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

637390:GCD22 RS05135
gene id: 637390:GCD22_RS05135
uniprot id: A0A5P9XP44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

637390:GCD22 RS04725
gene id: 637390:GCD22_RS04725
uniprot id: A0A5P9XND9
names: Similarity
messages: Belongs to the peptidase M1 family.

637390:GCD22 RS17270
gene id: 637390:GCD22_RS17270
uniprot id: A0A5P9XV71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

637390:GCD22 RS14645
gene id: 637390:GCD22_RS14645
uniprot id: A0A543Q4T8
names: Caution
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS13920
gene id: 637390:GCD22_RS13920
uniprot id: A0A5P9XTX0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS01200
gene id: 637390:GCD22_RS01200
uniprot id: A0A5P9XLF9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

637390:GCD22 RS12935
gene id: 637390:GCD22_RS12935
uniprot id: A0A5P9XTF3
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06725
gene id: 637390:GCD22_RS06725
uniprot id: A0A5P9XP67
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS09695
gene id: 637390:GCD22_RS09695
uniprot id: A0A5P9XQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS11210
gene id: 637390:GCD22_RS11210
uniprot id: A0A5P9XR91
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS02620
gene id: 637390:GCD22_RS02620
uniprot id: A0A5P9XPH2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

637390:GCD22 RS16125
gene id: 637390:GCD22_RS16125
uniprot id: A0A5P9XVV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

637390:GCD22 RS17190
gene id: 637390:GCD22_RS17190
uniprot id: A0A5P9XUC5
names: Similarity
messages: Belongs to the FBPase class 2 family.

637390:GCD22 RS17150
gene id: 637390:GCD22_RS17150
uniprot id: A0A5P9XVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

637390:GCD22 RS16325
gene id: 637390:GCD22_RS16325
uniprot id: A0A5P9XUP1
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS09940
gene id: 637390:GCD22_RS09940
uniprot id: A0A5P9XRV8
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

637390:GCD22 RS03185
gene id: 637390:GCD22_RS03185
uniprot id: A0A5P9XMC9
names: Similarity
messages: Belongs to the TrbG/VirB9 family.

637390:GCD22 RS02490
gene id: 637390:GCD22_RS02490
uniprot id: A0A543Q163
names: Caution
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

637390:GCD22 RS16040
gene id: 637390:GCD22_RS16040
uniprot id: A0A5P9XUP0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

637390:GCD22 RS15620
gene id: 637390:GCD22_RS15620
uniprot id: A0A5P9XTK7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS10400
gene id: 637390:GCD22_RS10400
uniprot id: A0A5P9XSU4
names: Similarity
messages: Belongs to the frataxin family.

637390:GCD22 RS01750
gene id: 637390:GCD22_RS01750
uniprot id: A0A543Q0T4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

637390:GCD22 RS00685
gene id: 637390:GCD22_RS00685
uniprot id: A0A5P9XL44
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

637390:GCD22 RS10195
gene id: 637390:GCD22_RS10195
uniprot id: A0A5P9XT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

637390:GCD22 RS14995
gene id: 637390:GCD22_RS14995
uniprot id: A0A5P9XT98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

637390:GCD22 RS15525
gene id: 637390:GCD22_RS15525
uniprot id: A0A5P9XVX0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

637390:GCD22 RS15360
gene id: 637390:GCD22_RS15360
uniprot id: A0A5P9XTH7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02400
gene id: 637390:GCD22_RS02400
uniprot id: A0A5P9XM15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

637390:GCD22 RS15835
gene id: 637390:GCD22_RS15835
uniprot id: A0A5P9XUX1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

637390:GCD22 RS16570
gene id: 637390:GCD22_RS16570
uniprot id: A0A5P9XV07
names: Similarity
messages: Belongs to the CFA/CMAS family.

637390:GCD22 RS15810
gene id: 637390:GCD22_RS15810
uniprot id: A0A5P9XTR0
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

637390:GCD22 RS17095
gene id: 637390:GCD22_RS17095
uniprot id: A0A5P9XVA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

637390:GCD22 RS14925
gene id: 637390:GCD22_RS14925
uniprot id: A0A5P9XT97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

637390:GCD22 RS11375
gene id: 637390:GCD22_RS11375
uniprot id: A0A543Q3I7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

637390:GCD22 RS17775
gene id: 637390:GCD22_RS17775
uniprot id: A0A5P9XUP7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS15705
gene id: 637390:GCD22_RS15705
uniprot id: A0A543Q5I5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS13020
gene id: 637390:GCD22_RS13020
uniprot id: A0A543Q3T2
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

637390:GCD22 RS13115
gene id: 637390:GCD22_RS13115
uniprot id: C5IJZ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS06130
gene id: 637390:GCD22_RS06130
uniprot id: A0A5P9XPP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

637390:GCD22 RS00880
gene id: 637390:GCD22_RS00880
uniprot id: A0A5P9XMZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

637390:GCD22 RS14070
gene id: 637390:GCD22_RS14070
uniprot id: A0A5P9XTZ2
names: Similarity
messages: Belongs to the GARS family.

637390:GCD22 RS05385
gene id: 637390:GCD22_RS05385
uniprot id: A0A543Q7K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

637390:GCD22 RS01630
gene id: 637390:GCD22_RS01630
uniprot id: A0A5P9XLM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS17580
gene id: 637390:GCD22_RS17580
uniprot id: A0A5P9XUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS04025
gene id: 637390:GCD22_RS04025
uniprot id: A0A5P9XMS0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

637390:GCD22 RS14145
gene id: 637390:GCD22_RS14145
uniprot id: A0A5P9XUD2
names: Similarity
messages: Belongs to the TonB-dependent receptor family.

637390:GCD22 RS06150
gene id: 637390:GCD22_RS06150
uniprot id: A0A5P9XPX6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

637390:GCD22 RS04915
gene id: 637390:GCD22_RS04915
uniprot id: A0A5P9XN77
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13070
gene id: 637390:GCD22_RS13070
uniprot id: A0A543Q3V0
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

637390:GCD22 RS06705
gene id: 637390:GCD22_RS06705
uniprot id: A0A5P9XP49
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16630
gene id: 637390:GCD22_RS16630
uniprot id: A0A5P9XVC3
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

637390:GCD22 RS01460
gene id: 637390:GCD22_RS01460
uniprot id: A0A5P9XNA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS14385
gene id: 637390:GCD22_RS14385
uniprot id: A0A5P9XV00
names: Similarity
messages: Belongs to the SAICAR synthetase family.

637390:GCD22 RS05835
gene id: 637390:GCD22_RS05835
uniprot id: A0A5P9XPQ1
names: Subcellular Location Annotation
messages: Secreted

637390:GCD22 RS05090
gene id: 637390:GCD22_RS05090
uniprot id: A0A543Q7E0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05830
gene id: 637390:GCD22_RS05830
uniprot id: A0A5P9XQG1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

637390:GCD22 RS05585
gene id: 637390:GCD22_RS05585
uniprot id: A0A543Q7M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

637390:GCD22 RS02825
gene id: 637390:GCD22_RS02825
uniprot id: A0A5P9XM70
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

637390:GCD22 RS16790
gene id: 637390:GCD22_RS16790
uniprot id: A0A5P9XU57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

637390:GCD22 RS05775
gene id: 637390:GCD22_RS05775
uniprot id: A0A5P9XNW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

637390:GCD22 RS06685
gene id: 637390:GCD22_RS06685
uniprot id: A0A5P9XQY7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

637390:GCD22 RS05370
gene id: 637390:GCD22_RS05370
uniprot id: A0A543Q7L7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleoid

637390:GCD22 RS16420
gene id: 637390:GCD22_RS16420
uniprot id: A0A5P9XTZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

637390:GCD22 RS04750
gene id: 637390:GCD22_RS04750
uniprot id: A0A5P9XN40
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS14910
gene id: 637390:GCD22_RS14910
uniprot id: A0A5P9XTZ0
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

637390:GCD22 RS09955
gene id: 637390:GCD22_RS09955
uniprot id: A0A543Q2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

637390:GCD22 RS09560
gene id: 637390:GCD22_RS09560
uniprot id: A0A5P9XRM7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS13075
gene id: 637390:GCD22_RS13075
uniprot id: A0A543Q3W4
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

637390:GCD22 RS16550
gene id: 637390:GCD22_RS16550
uniprot id: A0A5P9XVK7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06310
gene id: 637390:GCD22_RS06310
uniprot id: A0A5P9XQR3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

637390:GCD22 RS05140
gene id: 637390:GCD22_RS05140
uniprot id: A0A5P9XNB1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

637390:GCD22 RS17205
gene id: 637390:GCD22_RS17205
uniprot id: A0A5P9XVU0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS15275
gene id: 637390:GCD22_RS15275
uniprot id: A0A5P9XU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

637390:GCD22 RS05630
gene id: 637390:GCD22_RS05630
uniprot id: A0A543Q7M2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

637390:GCD22 RS06030
gene id: 637390:GCD22_RS06030
uniprot id: A0A5P9XQK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

637390:GCD22 RS01230
gene id: 637390:GCD22_RS01230
uniprot id: A0A5P9XLW7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

637390:GCD22 RS01810
gene id: 637390:GCD22_RS01810
uniprot id: A0A543Q0U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

637390:GCD22 RS00990
gene id: 637390:GCD22_RS00990
uniprot id: A0A543Q0E8
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

637390:GCD22 RS03895
gene id: 637390:GCD22_RS03895
uniprot id: A0A543PZ89
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02165
gene id: 637390:GCD22_RS02165
uniprot id: A0A543Q109
names: Similarity
messages: Belongs to the UPF0758 family.

637390:GCD22 RS01095
gene id: 637390:GCD22_RS01095
uniprot id: A0A543Q0G6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS07645
gene id: 637390:GCD22_RS07645
uniprot id: A0A5P9XQP2
names: Similarity
messages: Belongs to the type II topoisomerase GyrB family.

637390:GCD22 RS15315
gene id: 637390:GCD22_RS15315
uniprot id: A0A5P9XVT4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

637390:GCD22 RS04640
gene id: 637390:GCD22_RS04640
uniprot id: A0A5P9XN20
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16485
gene id: 637390:GCD22_RS16485
uniprot id: A0A5P9XW23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS15610
gene id: 637390:GCD22_RS15610
uniprot id: A0A5P9XUS8
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13105
gene id: 637390:GCD22_RS13105
uniprot id: A0A543Q3V1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO small chain family.
messages: Heterohexadecamer of 8 large and 8 small subunits.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS10355
gene id: 637390:GCD22_RS10355
uniprot id: A0A5P9XTA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

637390:GCD22 RS15135
gene id: 637390:GCD22_RS15135
uniprot id: A0A5P9XUV1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

637390:GCD22 RS02105
gene id: 637390:GCD22_RS02105
uniprot id: A0A543Q101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

637390:GCD22 RS01450
gene id: 637390:GCD22_RS01450
uniprot id: A0A5P9XLJ1
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS10255
gene id: 637390:GCD22_RS10255
uniprot id: A0A5P9XQR5
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

637390:GCD22 RS00850
gene id: 637390:GCD22_RS00850
uniprot id: A0A543Q0C2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

637390:GCD22 RS04860
gene id: 637390:GCD22_RS04860
uniprot id: A0A5P9XN63
names: Similarity
messages: Belongs to the peptidase S49 family.

637390:GCD22 RS00600
gene id: 637390:GCD22_RS00600
uniprot id: A0A543Q078
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

637390:GCD22 RS06520
gene id: 637390:GCD22_RS06520
uniprot id: A0A5P9XPA6
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS01650
gene id: 637390:GCD22_RS01650
uniprot id: A0A5P9XMF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

637390:GCD22 RS00150
gene id: 637390:GCD22_RS00150
uniprot id: A0A5P9XKW5
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

637390:GCD22 RS10130
gene id: 637390:GCD22_RS10130
uniprot id: A0A543Q2N4
names: Similarity
messages: Belongs to the YciI family.

637390:GCD22 RS05815
gene id: 637390:GCD22_RS05815
uniprot id: A0A5P9XPG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

637390:GCD22 RS11270
gene id: 637390:GCD22_RS11270
uniprot id: A0A543Q3E0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

637390:GCD22 RS02710
gene id: 637390:GCD22_RS02710
uniprot id: A0A5P9XN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

637390:GCD22 RS00920
gene id: 637390:GCD22_RS00920
uniprot id: A0A5P9XL89
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

637390:GCD22 RS12460
gene id: 637390:GCD22_RS12460
uniprot id: A0A5P9XS23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS07740
gene id: 637390:GCD22_RS07740
uniprot id: A0A543Q1T8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02900
gene id: 637390:GCD22_RS02900
uniprot id: A0A5P9XN19
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

637390:GCD22 RS10070
gene id: 637390:GCD22_RS10070
uniprot id: A0A5P9XSJ9
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

637390:GCD22 RS13880
gene id: 637390:GCD22_RS13880
uniprot id: A0A5P9XTD1
names: Similarity
messages: Belongs to the UPF0047 family.

637390:GCD22 RS02090
gene id: 637390:GCD22_RS02090
uniprot id: A0A543Q100
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

637390:GCD22 RS01190
gene id: 637390:GCD22_RS01190
uniprot id: A0A5P9XM49
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS04940
gene id: 637390:GCD22_RS04940
uniprot id: A0A543Q7B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

637390:GCD22 RS09215
gene id: 637390:GCD22_RS09215
uniprot id: A0A543Q2B9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

637390:GCD22 RS17540
gene id: 637390:GCD22_RS17540
uniprot id: A0A5P9XW06
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

637390:GCD22 RS02535
gene id: 637390:GCD22_RS02535
uniprot id: A0A5P9XMV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS12340
gene id: 637390:GCD22_RS12340
uniprot id: A0A543Q3P5
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

637390:GCD22 RS02390
gene id: 637390:GCD22_RS02390
uniprot id: A0A543Q151
names: Similarity
messages: Belongs to the glyoxalase I family.

637390:GCD22 RS13625
gene id: 637390:GCD22_RS13625
uniprot id: A0A5P9XUM3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

637390:GCD22 RS01275
gene id: 637390:GCD22_RS01275
uniprot id: A0A5P9XLF6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS02065
gene id: 637390:GCD22_RS02065
uniprot id: A0A543Q106
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

637390:GCD22 RS01270
gene id: 637390:GCD22_RS01270
uniprot id: A0A5P9XNS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

637390:GCD22 RS14105
gene id: 637390:GCD22_RS14105
uniprot id: A0A5P9XV82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).

637390:GCD22 RS02805
gene id: 637390:GCD22_RS02805
uniprot id: A0A543Q1C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS17070
gene id: 637390:GCD22_RS17070
uniprot id: A0A5P9XUF0
names: Similarity
messages: Belongs to the MobA/MobL family.

637390:GCD22 RS01990
gene id: 637390:GCD22_RS01990
uniprot id: A0A5P9XLU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

637390:GCD22 RS05795
gene id: 637390:GCD22_RS05795
uniprot id: A0A5P9XR09
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

637390:GCD22 RS01240
gene id: 637390:GCD22_RS01240
uniprot id: A0A5P9XM57
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS14830
gene id: 637390:GCD22_RS14830
uniprot id: A0A543Q4X9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

637390:GCD22 RS15500
gene id: 637390:GCD22_RS15500
uniprot id: A0A543Q5E9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

637390:GCD22 RS11455
gene id: 637390:GCD22_RS11455
uniprot id: A0A5P9XSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

637390:GCD22 RS10040
gene id: 637390:GCD22_RS10040
uniprot id: A0A5P9XRH0
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

637390:GCD22 RS05560
gene id: 637390:GCD22_RS05560
uniprot id: A0A543Q7M1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS03910
gene id: 637390:GCD22_RS03910
uniprot id: A0A5P9XMQ0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

637390:GCD22 RS15505
gene id: 637390:GCD22_RS15505
uniprot id: A0A543Q5E5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

637390:GCD22 RS02405
gene id: 637390:GCD22_RS02405
uniprot id: A0A5P9XNR3
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

637390:GCD22 RS02560
gene id: 637390:GCD22_RS02560
uniprot id: A0A5P9XN11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

637390:GCD22 RS06710
gene id: 637390:GCD22_RS06710
uniprot id: A0A5P9XPT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

637390:GCD22 RS06300
gene id: 637390:GCD22_RS06300
uniprot id: A0A5P9XNX9
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06715
gene id: 637390:GCD22_RS06715
uniprot id: A0A5P9XQ72
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS05365
gene id: 637390:GCD22_RS05365
uniprot id: A0A543Q7J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

637390:GCD22 RS15460
gene id: 637390:GCD22_RS15460
uniprot id: A0A5P9XU80
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS15775
gene id: 637390:GCD22_RS15775
uniprot id: A0A543Q5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

637390:GCD22 RS01705
gene id: 637390:GCD22_RS01705
uniprot id: A0A5P9XME3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

637390:GCD22 RS14875
gene id: 637390:GCD22_RS14875
uniprot id: A0A5P9XT84
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

637390:GCD22 RS04880
gene id: 637390:GCD22_RS04880
uniprot id: A0A5P9XNS2
names: Similarity
messages: Belongs to the GcvT family.

637390:GCD22 RS09800
gene id: 637390:GCD22_RS09800
uniprot id: A0A5P9XRV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS12200
gene id: 637390:GCD22_RS12200
uniprot id: A0A5P9XRW6
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

637390:GCD22 RS00975
gene id: 637390:GCD22_RS00975
uniprot id: A0A543Q0I3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS17555
gene id: 637390:GCD22_RS17555
uniprot id: A0A5P9XWM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

637390:GCD22 RS05500
gene id: 637390:GCD22_RS05500
uniprot id: A0A543Q7M0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

637390:GCD22 RS17300
gene id: 637390:GCD22_RS17300
uniprot id: A0A5P9XUE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

637390:GCD22 RS15665
gene id: 637390:GCD22_RS15665
uniprot id: A0A5P9XUG6
names: Similarity
messages: Belongs to the UPF0235 family.

637390:GCD22 RS02815
gene id: 637390:GCD22_RS02815
uniprot id: A0A5P9XNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS06260
gene id: 637390:GCD22_RS06260
uniprot id: A0A5P9XP50
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

637390:GCD22 RS10765
gene id: 637390:GCD22_RS10765
uniprot id: A0A5P9XSE5
names: Similarity
messages: Belongs to the DNA photolyase family.

637390:GCD22 RS14605
gene id: 637390:GCD22_RS14605
uniprot id: A0A5P9XT33
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS05100
gene id: 637390:GCD22_RS05100
uniprot id: A0A543Q7E8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS06700
gene id: 637390:GCD22_RS06700
uniprot id: A0A5P9XRJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

637390:GCD22 RS06235
gene id: 637390:GCD22_RS06235
uniprot id: A0A5P9XNU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS00690
gene id: 637390:GCD22_RS00690
uniprot id: A0A5P9XLL2
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

637390:GCD22 RS05690
gene id: 637390:GCD22_RS05690
uniprot id: A0A543Q7P1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04705
gene id: 637390:GCD22_RS04705
uniprot id: A0A5P9XNY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

637390:GCD22 RS15170
gene id: 637390:GCD22_RS15170
uniprot id: A0A543Q542
names: Similarity
messages: Belongs to the UPF0434 family.

637390:GCD22 RS00905
gene id: 637390:GCD22_RS00905
uniprot id: A0A5P9XLQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

637390:GCD22 RS02680
gene id: 637390:GCD22_RS02680
uniprot id: A0A5P9XMM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS17530
gene id: 637390:GCD22_RS17530
uniprot id: A0A543Q6W8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS00745
gene id: 637390:GCD22_RS00745
uniprot id: A0A5P9XLV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

637390:GCD22 RS09975
gene id: 637390:GCD22_RS09975
uniprot id: A0A5P9XQQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

637390:GCD22 RS01860
gene id: 637390:GCD22_RS01860
uniprot id: A0A5P9XMH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS00805
gene id: 637390:GCD22_RS00805
uniprot id: A0A5P9XLX0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

637390:GCD22 RS15780
gene id: 637390:GCD22_RS15780
uniprot id: A0A5P9XUV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

637390:GCD22 RS05470
gene id: 637390:GCD22_RS05470
uniprot id: A0A543Q7N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

637390:GCD22 RS03335
gene id: 637390:GCD22_RS03335
uniprot id: A0A543Q1L6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS16080
gene id: 637390:GCD22_RS16080
uniprot id: A0A5P9XTW1
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

637390:GCD22 RS02910
gene id: 637390:GCD22_RS02910
uniprot id: A0A5P9XM82
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

637390:GCD22 RS00830
gene id: 637390:GCD22_RS00830
uniprot id: A0A5P9XL71
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

637390:GCD22 RS05065
gene id: 637390:GCD22_RS05065
uniprot id: A0A5P9XP46
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

637390:GCD22 RS05300
gene id: 637390:GCD22_RS05300
uniprot id: A0A5P9XNC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Periplasm

637390:GCD22 RS16780
gene id: 637390:GCD22_RS16780
uniprot id: A0A5P9XU98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

637390:GCD22 RS14065
gene id: 637390:GCD22_RS14065
uniprot id: A0A543Q4E9
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

637390:GCD22 RS00910
gene id: 637390:GCD22_RS00910
uniprot id: A0A5P9XM21
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

637390:GCD22 RS02140
gene id: 637390:GCD22_RS02140
uniprot id: A0A543Q103
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

637390:GCD22 RS15165
gene id: 637390:GCD22_RS15165
uniprot id: A0A5P9XUJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

637390:GCD22 RS17360
gene id: 637390:GCD22_RS17360
uniprot id: A0A5P9XWT4
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS15385
gene id: 637390:GCD22_RS15385
uniprot id: A0A5P9XUN4
names: PTM
names: Similarity
messages: Belongs to the photoactive yellow protein family.
messages: The 4-hydroxycinnamic acid (p-coumaric acid) chromophore is covalently bound via a thioester linkage.

637390:GCD22 RS05210
gene id: 637390:GCD22_RS05210
uniprot id: A0A543Q7F8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

637390:GCD22 RS01865
gene id: 637390:GCD22_RS01865
uniprot id: A0A5P9XLR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

637390:GCD22 RS07060
gene id: 637390:GCD22_RS07060
uniprot id: A0A543Q4M6
names: Similarity
messages: Belongs to the GcvH family.

637390:GCD22 RS01520
gene id: 637390:GCD22_RS01520
uniprot id: A0A543Q0N3
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

637390:GCD22 RS02425
gene id: 637390:GCD22_RS02425
uniprot id: A0A543Q154
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

637390:GCD22 RS05155
gene id: 637390:GCD22_RS05155
uniprot id: A0A5P9XPB4
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

637390:GCD22 RS00195
gene id: 637390:GCD22_RS00195
uniprot id: A0A5P9XKX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

637390:GCD22 RS14190
gene id: 637390:GCD22_RS14190
uniprot id: A0A5P9XU22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

637390:GCD22 RS01955
gene id: 637390:GCD22_RS01955
uniprot id: A0A5P9XLT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

637390:GCD22 RS08765
gene id: 637390:GCD22_RS08765
uniprot id: A0A543Q1Z9
names: Caution
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS06625
gene id: 637390:GCD22_RS06625
uniprot id: A0A5P9XQ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS02645
gene id: 637390:GCD22_RS02645
uniprot id: A0A5P9XM35
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

637390:GCD22 RS12960
gene id: 637390:GCD22_RS12960
uniprot id: A0A5P9XTL7
names: Similarity
messages: Belongs to the YkuD family.

637390:GCD22 RS02010
gene id: 637390:GCD22_RS02010
uniprot id: A0A5P9XP74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

637390:GCD22 RS11650
gene id: 637390:GCD22_RS11650
uniprot id: A0A5P9XTI5
names: Similarity
messages: Belongs to the GSP E family.

637390:GCD22 RS00585
gene id: 637390:GCD22_RS00585
uniprot id: A0A5P9XMT8
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS14855
gene id: 637390:GCD22_RS14855
uniprot id: A0A543Q4X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

637390:GCD22 RS12005
gene id: 637390:GCD22_RS12005
uniprot id: A0A5P9XSY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

637390:GCD22 RS02715
gene id: 637390:GCD22_RS02715
uniprot id: A0A5P9XM51
names: Similarity
messages: Belongs to the FPG family.

637390:GCD22 RS09805
gene id: 637390:GCD22_RS09805
uniprot id: A0A5P9XQM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

637390:GCD22 RS01880
gene id: 637390:GCD22_RS01880
uniprot id: A0A5P9XMQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

637390:GCD22 RS04695
gene id: 637390:GCD22_RS04695
uniprot id: A0A5P9XN30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

637390:GCD22 RS15805
gene id: 637390:GCD22_RS15805
uniprot id: A0A5P9XV75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

637390:GCD22 RS17215
gene id: 637390:GCD22_RS17215
uniprot id: A0A543Q6B7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

637390:GCD22 RS16895
gene id: 637390:GCD22_RS16895
uniprot id: A0A5P9XWK9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS13425
gene id: 637390:GCD22_RS13425
uniprot id: A0A543Q3Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

637390:GCD22 RS05600
gene id: 637390:GCD22_RS05600
uniprot id: A0A543Q7P0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

637390:GCD22 RS06120
gene id: 637390:GCD22_RS06120
uniprot id: A0A5P9XPF2
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

637390:GCD22 RS11615
gene id: 637390:GCD22_RS11615
uniprot id: A0A5P9XRG3
names: Similarity
messages: Belongs to the bacterial secretin family.

637390:GCD22 RS03865
gene id: 637390:GCD22_RS03865
uniprot id: A0A5P9XQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS17450
gene id: 637390:GCD22_RS17450
uniprot id: A0A5P9XVA0
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

637390:GCD22 RS10915
gene id: 637390:GCD22_RS10915
uniprot id: A0A543Q377
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS14500
gene id: 637390:GCD22_RS14500
uniprot id: A0A5P9XV19
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

637390:GCD22 RS10010
gene id: 637390:GCD22_RS10010
uniprot id: A0A5P9XR84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

637390:GCD22 RS03760
gene id: 637390:GCD22_RS03760
uniprot id: A0A543PYZ0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS01415
gene id: 637390:GCD22_RS01415
uniprot id: A0A543Q0L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

637390:GCD22 RS09760
gene id: 637390:GCD22_RS09760
uniprot id: A0A5P9XT05
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

637390:GCD22 RS10760
gene id: 637390:GCD22_RS10760
uniprot id: A0A5P9XT18
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

637390:GCD22 RS02100
gene id: 637390:GCD22_RS02100
uniprot id: A0A5P9XNL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

637390:GCD22 RS13860
gene id: 637390:GCD22_RS13860
uniprot id: A0A543Q4A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

637390:GCD22 RS13975
gene id: 637390:GCD22_RS13975
uniprot id: A0A5P9XTY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

637390:GCD22 RS12950
gene id: 637390:GCD22_RS12950
uniprot id: A0A5P9XST3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

637390:GCD22 RS11350
gene id: 637390:GCD22_RS11350
uniprot id: A0A5P9XRH7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

637390:GCD22 RS05045
gene id: 637390:GCD22_RS05045
uniprot id: A0A543Q7D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS01150
gene id: 637390:GCD22_RS01150
uniprot id: A0A5P9XN44
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

637390:GCD22 RS15130
gene id: 637390:GCD22_RS15130
uniprot id: A0A543Q531
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

637390:GCD22 RS02860
gene id: 637390:GCD22_RS02860
uniprot id: A0A5P9XM92
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02360
gene id: 637390:GCD22_RS02360
uniprot id: A0A5P9XLZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

637390:GCD22 RS05950
gene id: 637390:GCD22_RS05950
uniprot id: A0A5P9XNP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

637390:GCD22 RS00580
gene id: 637390:GCD22_RS00580
uniprot id: A0A5P9XL47
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

637390:GCD22 RS17515
gene id: 637390:GCD22_RS17515
uniprot id: A0A5P9XUN2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

637390:GCD22 RS03945
gene id: 637390:GCD22_RS03945
uniprot id: A0A5P9XMP6
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS14450
gene id: 637390:GCD22_RS14450
uniprot id: A0A5P9XUH9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS17460
gene id: 637390:GCD22_RS17460
uniprot id: A0A5P9XW16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

637390:GCD22 RS06400
gene id: 637390:GCD22_RS06400
uniprot id: A0A5P9XPT8
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13210
gene id: 637390:GCD22_RS13210
uniprot id: A0A543Q3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

637390:GCD22 RS16150
gene id: 637390:GCD22_RS16150
uniprot id: A0A5P9XUR7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16530
gene id: 637390:GCD22_RS16530
uniprot id: A0A543Q602
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS15935
gene id: 637390:GCD22_RS15935
uniprot id: A0A5P9XUL8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

637390:GCD22 RS02835
gene id: 637390:GCD22_RS02835
uniprot id: A0A5P9XM69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS06600
gene id: 637390:GCD22_RS06600
uniprot id: A0A5P9XP37
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

637390:GCD22 RS00940
gene id: 637390:GCD22_RS00940
uniprot id: A0A543Q0D7
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

637390:GCD22 RS01120
gene id: 637390:GCD22_RS01120
uniprot id: A0A5P9XLU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

637390:GCD22 RS16095
gene id: 637390:GCD22_RS16095
uniprot id: A0A5P9XUQ1
names: Similarity
messages: Belongs to the thioredoxin family.

637390:GCD22 RS10460
gene id: 637390:GCD22_RS10460
uniprot id: A0A5P9XR00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

637390:GCD22 RS15420
gene id: 637390:GCD22_RS15420
uniprot id: A0A5P9XTI4
names: Similarity
messages: Belongs to the CFA/CMAS family.

637390:GCD22 RS15490
gene id: 637390:GCD22_RS15490
uniprot id: A0A5P9XUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

637390:GCD22 RS00960
gene id: 637390:GCD22_RS00960
uniprot id: A0A5P9XLR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS04260
gene id: 637390:GCD22_RS04260
uniprot id: A0A5P9XMW0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

637390:GCD22 RS00720
gene id: 637390:GCD22_RS00720
uniprot id: A0A543Q097
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06205
gene id: 637390:GCD22_RS06205
uniprot id: A0A543Q821
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02345
gene id: 637390:GCD22_RS02345
uniprot id: A0A5P9XM06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

637390:GCD22 RS10000
gene id: 637390:GCD22_RS10000
uniprot id: A0A5P9XRP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

637390:GCD22 RS17485
gene id: 637390:GCD22_RS17485
uniprot id: A0A5P9XVS5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

637390:GCD22 RS10115
gene id: 637390:GCD22_RS10115
uniprot id: A0A543Q2M3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

637390:GCD22 RS15570
gene id: 637390:GCD22_RS15570
uniprot id: A0A5P9XTL2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

637390:GCD22 RS12325
gene id: 637390:GCD22_RS12325
uniprot id: A0A5P9XSS0
names: Similarity
messages: Belongs to the UPF0145 family.

637390:GCD22 RS13140
gene id: 637390:GCD22_RS13140
uniprot id: A0A543Q3V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

637390:GCD22 RS15980
gene id: 637390:GCD22_RS15980
uniprot id: A0A5P9XTQ5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

637390:GCD22 RS03870
gene id: 637390:GCD22_RS03870
uniprot id: A0A5P9XMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

637390:GCD22 RS02395
gene id: 637390:GCD22_RS02395
uniprot id: A0A5P9XM00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

637390:GCD22 RS01435
gene id: 637390:GCD22_RS01435
uniprot id: A0A5P9XM07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

637390:GCD22 RS05525
gene id: 637390:GCD22_RS05525
uniprot id: A0A5P9XQV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

637390:GCD22 RS17470
gene id: 637390:GCD22_RS17470
uniprot id: A0A5P9XWV6
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

637390:GCD22 RS13215
gene id: 637390:GCD22_RS13215
uniprot id: A0A543Q404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

637390:GCD22 RS16025
gene id: 637390:GCD22_RS16025
uniprot id: A0A5P9XTV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

637390:GCD22 RS17045
gene id: 637390:GCD22_RS17045
uniprot id: A0A543Q4Z8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

637390:GCD22 RS02040
gene id: 637390:GCD22_RS02040
uniprot id: A0A543Q0Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

637390:GCD22 RS10750
gene id: 637390:GCD22_RS10750
uniprot id: A0A5P9XR68
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS05375
gene id: 637390:GCD22_RS05375
uniprot id: A0A543Q7I3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

637390:GCD22 RS09135
gene id: 637390:GCD22_RS09135
uniprot id: A0A543Q2A7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02735
gene id: 637390:GCD22_RS02735
uniprot id: A0A5P9XM50
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

637390:GCD22 RS16695
gene id: 637390:GCD22_RS16695
uniprot id: A0A5P9XVD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

637390:GCD22 RS05055
gene id: 637390:GCD22_RS05055
uniprot id: A0A5P9XN86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS17290
gene id: 637390:GCD22_RS17290
uniprot id: A0A5P9XWS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.
messages: The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).

637390:GCD22 RS14560
gene id: 637390:GCD22_RS14560
uniprot id: A0A5P9XVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OprB family.
messages: Cell outer membrane

637390:GCD22 RS12855
gene id: 637390:GCD22_RS12855
uniprot id: A0A5P9XTJ6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

637390:GCD22 RS15305
gene id: 637390:GCD22_RS15305
uniprot id: A0A5P9XUY2
names: Similarity
messages: Belongs to the RecJ family.

637390:GCD22 RS06290
gene id: 637390:GCD22_RS06290
uniprot id: A0A5P9XPS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

637390:GCD22 RS00145
gene id: 637390:GCD22_RS00145
uniprot id: A0A5P9XKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

637390:GCD22 RS01025
gene id: 637390:GCD22_RS01025
uniprot id: A0A5P9XLB1
names: Similarity
messages: Belongs to the HPrK/P family.

637390:GCD22 RS04355
gene id: 637390:GCD22_RS04355
uniprot id: A0A5P9XPQ2
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS00210
gene id: 637390:GCD22_RS00210
uniprot id: A0A5P9XKV2
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

637390:GCD22 RS02580
gene id: 637390:GCD22_RS02580
uniprot id: A0A5P9XMK3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

637390:GCD22 RS10135
gene id: 637390:GCD22_RS10135
uniprot id: A0A5P9XQT8
names: Similarity
messages: Belongs to the BolA/IbaG family.

637390:GCD22 RS13585
gene id: 637390:GCD22_RS13585
uniprot id: A0A5P9XSI4
names: Similarity
messages: Belongs to the GcvH family.

637390:GCD22 RS15115
gene id: 637390:GCD22_RS15115
uniprot id: A0A5P9XUI9
names: Similarity
messages: Belongs to the peptidase S41A family.

637390:GCD22 RS12945
gene id: 637390:GCD22_RS12945
uniprot id: A0A5P9XSC1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS01940
gene id: 637390:GCD22_RS01940
uniprot id: A0A5P9XLT6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS04870
gene id: 637390:GCD22_RS04870
uniprot id: A0A5P9XN55
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

637390:GCD22 RS01105
gene id: 637390:GCD22_RS01105
uniprot id: A0A5P9XLC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

637390:GCD22 RS15790
gene id: 637390:GCD22_RS15790
uniprot id: A0A543Q5J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

637390:GCD22 RS05435
gene id: 637390:GCD22_RS05435
uniprot id: A0A543Q7K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

637390:GCD22 RS02225
gene id: 637390:GCD22_RS02225
uniprot id: A0A543Q133
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS00040
gene id: 637390:GCD22_RS00040
uniprot id: A0A543Q728
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

637390:GCD22 RS17210
gene id: 637390:GCD22_RS17210
uniprot id: A0A5P9XUE3
names: Similarity
messages: Belongs to the pyruvate kinase family.

637390:GCD22 RS04800
gene id: 637390:GCD22_RS04800
uniprot id: A0A5P9XN54
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

637390:GCD22 RS01110
gene id: 637390:GCD22_RS01110
uniprot id: A0A543Q0H5
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04920
gene id: 637390:GCD22_RS04920
uniprot id: A0A543Q7B7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

637390:GCD22 RS00590
gene id: 637390:GCD22_RS00590
uniprot id: A0A5P9XM03
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02025
gene id: 637390:GCD22_RS02025
uniprot id: A0A543Q144
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

637390:GCD22 RS02340
gene id: 637390:GCD22_RS02340
uniprot id: A0A5P9XLZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

637390:GCD22 RS04330
gene id: 637390:GCD22_RS04330
uniprot id: A0A543PZQ8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05455
gene id: 637390:GCD22_RS05455
uniprot id: A0A543Q7J9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

637390:GCD22 RS11290
gene id: 637390:GCD22_RS11290
uniprot id: A0A5P9XRG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

637390:GCD22 RS14085
gene id: 637390:GCD22_RS14085
uniprot id: A0A5P9XTL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

637390:GCD22 RS05145
gene id: 637390:GCD22_RS05145
uniprot id: A0A5P9XNL0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

637390:GCD22 RS06075
gene id: 637390:GCD22_RS06075
uniprot id: A0A543Q7Y7
names: Similarity
messages: Belongs to the type III secretion exporter family.

637390:GCD22 RS00885
gene id: 637390:GCD22_RS00885
uniprot id: A0A5P9XM60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

637390:GCD22 RS01010
gene id: 637390:GCD22_RS01010
uniprot id: A0A5P9XLS7
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

637390:GCD22 RS01965
gene id: 637390:GCD22_RS01965
uniprot id: A0A543Q0Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

637390:GCD22 RS00820
gene id: 637390:GCD22_RS00820
uniprot id: A0A543Q0B2
names: Similarity
messages: Belongs to the citrate synthase family.

637390:GCD22 RS01540
gene id: 637390:GCD22_RS01540
uniprot id: A0A543Q0N7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

637390:GCD22 RS02335
gene id: 637390:GCD22_RS02335
uniprot id: A0A543Q138
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

637390:GCD22 RS15970
gene id: 637390:GCD22_RS15970
uniprot id: A0A5P9XTU3
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13785
gene id: 637390:GCD22_RS13785
uniprot id: A0A543Q469
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

637390:GCD22 RS15580
gene id: 637390:GCD22_RS15580
uniprot id: A0A5P9XTI9
names: Similarity
messages: Belongs to the YkuD family.

637390:GCD22 RS04890
gene id: 637390:GCD22_RS04890
uniprot id: A0A5P9XP09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

637390:GCD22 RS05980
gene id: 637390:GCD22_RS05980
uniprot id: A0A5P9XQJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

637390:GCD22 RS11380
gene id: 637390:GCD22_RS11380
uniprot id: A0A5P9XRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

637390:GCD22 RS09980
gene id: 637390:GCD22_RS09980
uniprot id: A0A5P9XT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

637390:GCD22 RS12180
gene id: 637390:GCD22_RS12180
uniprot id: A0A5P9XSH2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

637390:GCD22 RS10740
gene id: 637390:GCD22_RS10740
uniprot id: A0A5P9XSD8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

637390:GCD22 RS01145
gene id: 637390:GCD22_RS01145
uniprot id: A0A543Q0H8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS09960
gene id: 637390:GCD22_RS09960
uniprot id: A0A543Q2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

637390:GCD22 RS13915
gene id: 637390:GCD22_RS13915
uniprot id: A0A5P9XTW2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS16645
gene id: 637390:GCD22_RS16645
uniprot id: A0A5P9XUW0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

637390:GCD22 RS05005
gene id: 637390:GCD22_RS05005
uniprot id: A0A5P9XNU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

637390:GCD22 RS15105
gene id: 637390:GCD22_RS15105
uniprot id: A0A5P9XU62
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

637390:GCD22 RS15100
gene id: 637390:GCD22_RS15100
uniprot id: A0A5P9XTB8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

637390:GCD22 RS02820
gene id: 637390:GCD22_RS02820
uniprot id: A0A543Q1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS05635
gene id: 637390:GCD22_RS05635
uniprot id: A0A543Q7Q8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

637390:GCD22 RS06095
gene id: 637390:GCD22_RS06095
uniprot id: A0A5P9XQL9
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

637390:GCD22 RS06620
gene id: 637390:GCD22_RS06620
uniprot id: A0A5P9XPQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

637390:GCD22 RS01960
gene id: 637390:GCD22_RS01960
uniprot id: A0A543Q0X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

637390:GCD22 RS07725
gene id: 637390:GCD22_RS07725
uniprot id: A0A5P9XRY1
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

637390:GCD22 RS05860
gene id: 637390:GCD22_RS05860
uniprot id: A0A5P9XPJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

637390:GCD22 RS04980
gene id: 637390:GCD22_RS04980
uniprot id: A0A543Q7D6
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02050
gene id: 637390:GCD22_RS02050
uniprot id: A0A543Q0Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

637390:GCD22 RS10050
gene id: 637390:GCD22_RS10050
uniprot id: A0A5P9XRQ0
names: Similarity
messages: Belongs to the DEAD box helicase family.

637390:GCD22 RS16140
gene id: 637390:GCD22_RS16140
uniprot id: A0A5P9XW75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

637390:GCD22 RS03995
gene id: 637390:GCD22_RS03995
uniprot id: A0A543PZ78
names: Caution
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05985
gene id: 637390:GCD22_RS05985
uniprot id: A0A5P9XPT7
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

637390:GCD22 RS16535
gene id: 637390:GCD22_RS16535
uniprot id: A0A543Q613
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS05915
gene id: 637390:GCD22_RS05915
uniprot id: A0A5P9XPI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

637390:GCD22 RS16335
gene id: 637390:GCD22_RS16335
uniprot id: A0A543Q5X4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS17225
gene id: 637390:GCD22_RS17225
uniprot id: A0A543Q6D3
names: Caution
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS06000
gene id: 637390:GCD22_RS06000
uniprot id: A0A543Q7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

637390:GCD22 RS01480
gene id: 637390:GCD22_RS01480
uniprot id: A0A5P9XLJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein.
messages: Membrane

637390:GCD22 RS02115
gene id: 637390:GCD22_RS02115
uniprot id: A0A543Q0Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

637390:GCD22 RS06430
gene id: 637390:GCD22_RS06430
uniprot id: A0A5P9XP07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

637390:GCD22 RS17570
gene id: 637390:GCD22_RS17570
uniprot id: A0A5P9XUP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

637390:GCD22 RS17510
gene id: 637390:GCD22_RS17510
uniprot id: A0A5P9XW26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS15020
gene id: 637390:GCD22_RS15020
uniprot id: A0A543Q4Z8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

637390:GCD22 RS16865
gene id: 637390:GCD22_RS16865
uniprot id: A0A5P9XVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

637390:GCD22 RS09945
gene id: 637390:GCD22_RS09945
uniprot id: A0A543Q2L4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

637390:GCD22 RS16210
gene id: 637390:GCD22_RS16210
uniprot id: A0A5P9XV38
names: Similarity
messages: Belongs to the GSP E family.

637390:GCD22 RS00085
gene id: 637390:GCD22_RS00085
uniprot id: A0A5P9XLI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

637390:GCD22 RS09875
gene id: 637390:GCD22_RS09875
uniprot id: A0A5P9XQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

637390:GCD22 RS10430
gene id: 637390:GCD22_RS10430
uniprot id: A0A5P9XRP0
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02145
gene id: 637390:GCD22_RS02145
uniprot id: A0A5P9XLW1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

637390:GCD22 RS01505
gene id: 637390:GCD22_RS01505
uniprot id: A0A5P9XLK1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

637390:GCD22 RS05540
gene id: 637390:GCD22_RS05540
uniprot id: A0A543Q7P3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS13130
gene id: 637390:GCD22_RS13130
uniprot id: A0A5P9XS78
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

637390:GCD22 RS03905
gene id: 637390:GCD22_RS03905
uniprot id: A0A5P9XNP7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

637390:GCD22 RS16775
gene id: 637390:GCD22_RS16775
uniprot id: A0A5P9XVP8
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

637390:GCD22 RS01625
gene id: 637390:GCD22_RS01625
uniprot id: A0A5P9XMK5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

637390:GCD22 RS15080
gene id: 637390:GCD22_RS15080
uniprot id: A0A543Q517
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

637390:GCD22 RS04635
gene id: 637390:GCD22_RS04635
uniprot id: A0A5P9XQF3
names: Similarity
messages: Belongs to the peptidase S11 family.

637390:GCD22 RS00320
gene id: 637390:GCD22_RS00320
uniprot id: A0A5P9XMN7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

637390:GCD22 RS10780
gene id: 637390:GCD22_RS10780
uniprot id: A0A5P9XR15
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

637390:GCD22 RS00680
gene id: 637390:GCD22_RS00680
uniprot id: A0A5P9XNG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS09775
gene id: 637390:GCD22_RS09775
uniprot id: A0A5P9XRB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

637390:GCD22 RS00700
gene id: 637390:GCD22_RS00700
uniprot id: A0A5P9XLU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

637390:GCD22 RS10440
gene id: 637390:GCD22_RS10440
uniprot id: A0A5P9XRX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

637390:GCD22 RS00930
gene id: 637390:GCD22_RS00930
uniprot id: A0A543Q0D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

637390:GCD22 RS09640
gene id: 637390:GCD22_RS09640
uniprot id: A0A5P9XRS9
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS10755
gene id: 637390:GCD22_RS10755
uniprot id: A0A5P9XRM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS00165
gene id: 637390:GCD22_RS00165
uniprot id: A0A5P9XKU3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

637390:GCD22 RS11880
gene id: 637390:GCD22_RS11880
uniprot id: A0A5P9XRQ3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS13965
gene id: 637390:GCD22_RS13965
uniprot id: A0A5P9XTL5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

637390:GCD22 RS15345
gene id: 637390:GCD22_RS15345
uniprot id: A0A543Q5B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

637390:GCD22 RS02480
gene id: 637390:GCD22_RS02480
uniprot id: A0A5P9XM23
names: Similarity
messages: Belongs to the YoeB family.

637390:GCD22 RS11230
gene id: 637390:GCD22_RS11230
uniprot id: A0A5P9XRW9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS16010
gene id: 637390:GCD22_RS16010
uniprot id: A0A5P9XVT3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

637390:GCD22 RS12940
gene id: 637390:GCD22_RS12940
uniprot id: A0A5P9XTC4
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02270
gene id: 637390:GCD22_RS02270
uniprot id: A0A543Q128
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05410
gene id: 637390:GCD22_RS05410
uniprot id: A0A543Q7K2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS14430
gene id: 637390:GCD22_RS14430
uniprot id: A0A543Q4K6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

637390:GCD22 RS17505
gene id: 637390:GCD22_RS17505
uniprot id: A0A5P9XWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

637390:GCD22 RS15955
gene id: 637390:GCD22_RS15955
uniprot id: A0A543Q5M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

637390:GCD22 RS00895
gene id: 637390:GCD22_RS00895
uniprot id: A0A5P9XNK7
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

637390:GCD22 RS02765
gene id: 637390:GCD22_RS02765
uniprot id: A0A5P9XN51
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

637390:GCD22 RS14110
gene id: 637390:GCD22_RS14110
uniprot id: A0A5P9XST4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS12565
gene id: 637390:GCD22_RS12565
uniprot id: A0A5P9XS43
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS02850
gene id: 637390:GCD22_RS02850
uniprot id: A0A5P9XMZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS05595
gene id: 637390:GCD22_RS05595
uniprot id: A0A543Q7P8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

637390:GCD22 RS04700
gene id: 637390:GCD22_RS04700
uniprot id: A0A5P9XNP1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

637390:GCD22 RS03915
gene id: 637390:GCD22_RS03915
uniprot id: A0A5P9XQ27
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

637390:GCD22 RS17770
gene id: 637390:GCD22_RS17770
uniprot id: A0A5P9XW45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

637390:GCD22 RS16770
gene id: 637390:GCD22_RS16770
uniprot id: A0A5P9XW72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

637390:GCD22 RS12975
gene id: 637390:GCD22_RS12975
uniprot id: A0A543Q3U3
names: Similarity
messages: Belongs to the RutC family.

637390:GCD22 RS15195
gene id: 637390:GCD22_RS15195
uniprot id: A0A543Q541
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04060
gene id: 637390:GCD22_RS04060
uniprot id: A0A5P9XNK2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

637390:GCD22 RS05050
gene id: 637390:GCD22_RS05050
uniprot id: A0A543Q7D7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

637390:GCD22 RS05910
gene id: 637390:GCD22_RS05910
uniprot id: A0A5P9XPK3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

637390:GCD22 RS04775
gene id: 637390:GCD22_RS04775
uniprot id: A0A5P9XNY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

637390:GCD22 RS01175
gene id: 637390:GCD22_RS01175
uniprot id: A0A5P9XLV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS04925
gene id: 637390:GCD22_RS04925
uniprot id: A0A543Q7C4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

637390:GCD22 RS14185
gene id: 637390:GCD22_RS14185
uniprot id: A0A543Q4I2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS13415
gene id: 637390:GCD22_RS13415
uniprot id: A0A5P9XSK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

637390:GCD22 RS14400
gene id: 637390:GCD22_RS14400
uniprot id: A0A5P9XVC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

637390:GCD22 RS01475
gene id: 637390:GCD22_RS01475
uniprot id: A0A5P9XNW2
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

637390:GCD22 RS17835
gene id: 637390:GCD22_RS17835
uniprot id: A0A5P9XUQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS02615
gene id: 637390:GCD22_RS02615
uniprot id: A0A5P9XM32
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

637390:GCD22 RS05430
gene id: 637390:GCD22_RS05430
uniprot id: A0A5P9XP11
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS10350
gene id: 637390:GCD22_RS10350
uniprot id: A0A5P9XQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

637390:GCD22 RS16525
gene id: 637390:GCD22_RS16525
uniprot id: A0A543Q612
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17090
gene id: 637390:GCD22_RS17090
uniprot id: A0A543Q685
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05935
gene id: 637390:GCD22_RS05935
uniprot id: A0A5P9XPS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

637390:GCD22 RS10110
gene id: 637390:GCD22_RS10110
uniprot id: A0A5P9XQU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS10105
gene id: 637390:GCD22_RS10105
uniprot id: A0A5P9XRR0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

637390:GCD22 RS00200
gene id: 637390:GCD22_RS00200
uniprot id: A0A5P9XML7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

637390:GCD22 RS16735
gene id: 637390:GCD22_RS16735
uniprot id: A0A5P9XWI3
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

637390:GCD22 RS13660
gene id: 637390:GCD22_RS13660
uniprot id: A0A5P9XSP3
names: Similarity
messages: Belongs to the RelE toxin family.

637390:GCD22 RS06660
gene id: 637390:GCD22_RS06660
uniprot id: A0A5P9XP36
names: Similarity
messages: Belongs to the thioredoxin family.

637390:GCD22 RS00705
gene id: 637390:GCD22_RS00705
uniprot id: A0A5P9XL48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS00795
gene id: 637390:GCD22_RS00795
uniprot id: A0A543Q0B1
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

637390:GCD22 RS05780
gene id: 637390:GCD22_RS05780
uniprot id: A0A5P9XQF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

637390:GCD22 RS04000
gene id: 637390:GCD22_RS04000
uniprot id: A0A543PZC0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

637390:GCD22 RS15770
gene id: 637390:GCD22_RS15770
uniprot id: A0A5P9XTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

637390:GCD22 RS03705
gene id: 637390:GCD22_RS03705
uniprot id: A0A5P9XMK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

637390:GCD22 RS04295
gene id: 637390:GCD22_RS04295
uniprot id: A0A5P9XMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS01995
gene id: 637390:GCD22_RS01995
uniprot id: A0A5P9XLS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

637390:GCD22 RS01445
gene id: 637390:GCD22_RS01445
uniprot id: A0A5P9XM98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS15940
gene id: 637390:GCD22_RS15940
uniprot id: A0A5P9XUY7
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

637390:GCD22 RS15340
gene id: 637390:GCD22_RS15340
uniprot id: A0A543Q5C0
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

637390:GCD22 RS17195
gene id: 637390:GCD22_RS17195
uniprot id: A0A5P9XVC4
names: Similarity
messages: Belongs to the transketolase family.

637390:GCD22 RS01245
gene id: 637390:GCD22_RS01245
uniprot id: A0A5P9XLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

637390:GCD22 RS03795
gene id: 637390:GCD22_RS03795
uniprot id: A0A5P9XPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS02130
gene id: 637390:GCD22_RS02130
uniprot id: A0A543Q110
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

637390:GCD22 RS01830
gene id: 637390:GCD22_RS01830
uniprot id: A0A5P9XMP1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS01400
gene id: 637390:GCD22_RS01400
uniprot id: A0A543Q0R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

637390:GCD22 RS05465
gene id: 637390:GCD22_RS05465
uniprot id: A0A5P9XNH2
names: Similarity
messages: Belongs to the YfgM family.

637390:GCD22 RS17760
gene id: 637390:GCD22_RS17760
uniprot id: A0A5P9XVX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

637390:GCD22 RS17220
gene id: 637390:GCD22_RS17220
uniprot id: A0A5P9XWF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

637390:GCD22 RS13200
gene id: 637390:GCD22_RS13200
uniprot id: A0A5P9XTH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

637390:GCD22 RS05975
gene id: 637390:GCD22_RS05975
uniprot id: A0A5P9XP08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

637390:GCD22 RS01070
gene id: 637390:GCD22_RS01070
uniprot id: A0A5P9XLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

637390:GCD22 RS04065
gene id: 637390:GCD22_RS04065
uniprot id: A0A543PZB8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS12365
gene id: 637390:GCD22_RS12365
uniprot id: A0A5P9XRZ4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS05405
gene id: 637390:GCD22_RS05405
uniprot id: A0A543Q7J5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

637390:GCD22 RS10075
gene id: 637390:GCD22_RS10075
uniprot id: A0A5P9XS10
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

637390:GCD22 RS04080
gene id: 637390:GCD22_RS04080
uniprot id: A0A5P9XPJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS16640
gene id: 637390:GCD22_RS16640
uniprot id: A0A543Q646
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

637390:GCD22 RS00235
gene id: 637390:GCD22_RS00235
uniprot id: A0A5P9XLL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

637390:GCD22 RS05955
gene id: 637390:GCD22_RS05955
uniprot id: A0A5P9XPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

637390:GCD22 RS00735
gene id: 637390:GCD22_RS00735
uniprot id: A0A543Q0A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

637390:GCD22 RS16510
gene id: 637390:GCD22_RS16510
uniprot id: A0A5P9XUZ5
names: Similarity
messages: Belongs to the peptidase C59 family.

637390:GCD22 RS05920
gene id: 637390:GCD22_RS05920
uniprot id: A0A5P9XNQ4
names: Subcellular Location Annotation
messages: Cytoplasm

637390:GCD22 RS09925
gene id: 637390:GCD22_RS09925
uniprot id: A0A543Q2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

637390:GCD22 RS06655
gene id: 637390:GCD22_RS06655
uniprot id: A0A5P9XRH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

637390:GCD22 RS05400
gene id: 637390:GCD22_RS05400
uniprot id: A0A543Q7K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

637390:GCD22 RS15640
gene id: 637390:GCD22_RS15640
uniprot id: A0A543Q5G8
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

637390:GCD22 RS07675
gene id: 637390:GCD22_RS07675
uniprot id: A0A5P9XQ64
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

637390:GCD22 RS14795
gene id: 637390:GCD22_RS14795
uniprot id: A0A5P9XUC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

637390:GCD22 RS10715
gene id: 637390:GCD22_RS10715
uniprot id: A0A543Q2Z8
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS06480
gene id: 637390:GCD22_RS06480
uniprot id: A0A5P9XQ35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

637390:GCD22 RS16135
gene id: 637390:GCD22_RS16135
uniprot id: A0A543Q5S1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

637390:GCD22 RS00730
gene id: 637390:GCD22_RS00730
uniprot id: A0A5P9XL55
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS14215
gene id: 637390:GCD22_RS14215
uniprot id: A0A5P9XSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

637390:GCD22 RS17495
gene id: 637390:GCD22_RS17495
uniprot id: A0A5P9XUJ3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

637390:GCD22 RS02200
gene id: 637390:GCD22_RS02200
uniprot id: A0A5P9XLX1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

637390:GCD22 RS02045
gene id: 637390:GCD22_RS02045
uniprot id: A0A543Q0Y7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

637390:GCD22 RS05930
gene id: 637390:GCD22_RS05930
uniprot id: A0A5P9XQI3
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.

637390:GCD22 RS15520
gene id: 637390:GCD22_RS15520
uniprot id: A0A5P9XTK0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

637390:GCD22 RS10435
gene id: 637390:GCD22_RS10435
uniprot id: A0A5P9XS59
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS01535
gene id: 637390:GCD22_RS01535
uniprot id: A0A5P9XNX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

637390:GCD22 RS15190
gene id: 637390:GCD22_RS15190
uniprot id: A0A5P9XTE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

637390:GCD22 RS06025
gene id: 637390:GCD22_RS06025
uniprot id: A0A5P9XP17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

637390:GCD22 RS00225
gene id: 637390:GCD22_RS00225
uniprot id: A0A543Q770
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

637390:GCD22 RS05745
gene id: 637390:GCD22_RS05745
uniprot id: A0A543Q7S8
names: Similarity
messages: Belongs to the MotB family.

637390:GCD22 RS17325
gene id: 637390:GCD22_RS17325
uniprot id: A0A5P9XVV8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

637390:GCD22 RS01730
gene id: 637390:GCD22_RS01730
uniprot id: A0A5P9XNF2
names: Similarity
messages: Belongs to the GSP E family.

637390:GCD22 RS15945
gene id: 637390:GCD22_RS15945
uniprot id: A0A543Q5N3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

637390:GCD22 RS17550
gene id: 637390:GCD22_RS17550
uniprot id: A0A5P9XVC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

637390:GCD22 RS16620
gene id: 637390:GCD22_RS16620
uniprot id: A0A5P9XU27
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

637390:GCD22 RS10465
gene id: 637390:GCD22_RS10465
uniprot id: A0A5P9XTC9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

637390:GCD22 RS06650
gene id: 637390:GCD22_RS06650
uniprot id: A0A5P9XP48
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

637390:GCD22 RS14130
gene id: 637390:GCD22_RS14130
uniprot id: A0A5P9XSX6
names: Similarity
messages: Belongs to the bacterial phospholipase C family.

637390:GCD22 RS14805
gene id: 637390:GCD22_RS14805
uniprot id: A0A5P9XT81
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17170
gene id: 637390:GCD22_RS17170
uniprot id: A0A5P9XWE8
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS07455
gene id: 637390:GCD22_RS07455
uniprot id: A0A543Q427
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS00265
gene id: 637390:GCD22_RS00265
uniprot id: A0A5P9XN98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS13775
gene id: 637390:GCD22_RS13775
uniprot id: A0A543Q482
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

637390:GCD22 RS01980
gene id: 637390:GCD22_RS01980
uniprot id: A0A543Q0X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

637390:GCD22 RS06020
gene id: 637390:GCD22_RS06020
uniprot id: A0A5P9XNS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

637390:GCD22 RS01030
gene id: 637390:GCD22_RS01030
uniprot id: A0A543Q0G1
names: Caution
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS01785
gene id: 637390:GCD22_RS01785
uniprot id: A0A543Q0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

637390:GCD22 RS09145
gene id: 637390:GCD22_RS09145
uniprot id: A0A543Q261
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04685
gene id: 637390:GCD22_RS04685
uniprot id: A0A543PZX1
names: Caution
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02420
gene id: 637390:GCD22_RS02420
uniprot id: A0A5P9XPD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

637390:GCD22 RS02150
gene id: 637390:GCD22_RS02150
uniprot id: A0A543Q105
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

637390:GCD22 RS13855
gene id: 637390:GCD22_RS13855
uniprot id: A0A543Q4B7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS03675
gene id: 637390:GCD22_RS03675
uniprot id: A0A5P9XNE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

637390:GCD22 RS17650
gene id: 637390:GCD22_RS17650
uniprot id: A0A5P9XW28
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06115
gene id: 637390:GCD22_RS06115
uniprot id: A0A5P9XNS0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

637390:GCD22 RS16360
gene id: 637390:GCD22_RS16360
uniprot id: A0A543Q5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS03180
gene id: 637390:GCD22_RS03180
uniprot id: A0A5P9XN52
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS12290
gene id: 637390:GCD22_RS12290
uniprot id: A0A5P9XTX7
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

637390:GCD22 RS05760
gene id: 637390:GCD22_RS05760
uniprot id: A0A5P9XPH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

637390:GCD22 RS09795
gene id: 637390:GCD22_RS09795
uniprot id: A0A5P9XSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS11410
gene id: 637390:GCD22_RS11410
uniprot id: A0A5P9XTE2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS06555
gene id: 637390:GCD22_RS06555
uniprot id: A0A5P9XPP3
names: Similarity
messages: Belongs to the PhoH family.

637390:GCD22 RS17370
gene id: 637390:GCD22_RS17370
uniprot id: A0A5P9XVF8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

637390:GCD22 RS07435
gene id: 637390:GCD22_RS07435
uniprot id: A0A5P9XPF8
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02895
gene id: 637390:GCD22_RS02895
uniprot id: A0A543Q1E6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

637390:GCD22 RS02845
gene id: 637390:GCD22_RS02845
uniprot id: A0A543Q1D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS15645
gene id: 637390:GCD22_RS15645
uniprot id: A0A5P9XV43
names: Function
names: Similarity
messages: Belongs to the RuBisCO large chain family. Type II subfamily.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

637390:GCD22 RS10175
gene id: 637390:GCD22_RS10175
uniprot id: A0A5P9XSM9
names: Similarity
messages: Belongs to the thioredoxin family.

637390:GCD22 RS16555
gene id: 637390:GCD22_RS16555
uniprot id: A0A5P9XU63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

637390:GCD22 RS00740
gene id: 637390:GCD22_RS00740
uniprot id: A0A543Q0A9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

637390:GCD22 RS02055
gene id: 637390:GCD22_RS02055
uniprot id: A0A543Q0Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

637390:GCD22 RS02590
gene id: 637390:GCD22_RS02590
uniprot id: A0A5P9XMU1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS05800
gene id: 637390:GCD22_RS05800
uniprot id: A0A5P9XNL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

637390:GCD22 RS01800
gene id: 637390:GCD22_RS01800
uniprot id: A0A5P9XMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS09240
gene id: 637390:GCD22_RS09240
uniprot id: A0A5P9XRG2
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

637390:GCD22 RS05675
gene id: 637390:GCD22_RS05675
uniprot id: A0A543Q7P6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

637390:GCD22 RS10390
gene id: 637390:GCD22_RS10390
uniprot id: A0A5P9XQZ9
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

637390:GCD22 RS15465
gene id: 637390:GCD22_RS15465
uniprot id: A0A5P9XVI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

637390:GCD22 RS01615
gene id: 637390:GCD22_RS01615
uniprot id: A0A5P9XLN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

637390:GCD22 RS14495
gene id: 637390:GCD22_RS14495
uniprot id: A0A5P9XTR8
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

637390:GCD22 RS00140
gene id: 637390:GCD22_RS00140
uniprot id: A0A543Q762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

637390:GCD22 RS13110
gene id: 637390:GCD22_RS13110
uniprot id: C5IJZ6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterohexadecamer of 8 large chains and 8 small chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

637390:GCD22 RS05125
gene id: 637390:GCD22_RS05125
uniprot id: A0A5P9XNW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

637390:GCD22 RS09420
gene id: 637390:GCD22_RS09420
uniprot id: A0A5P9XRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell membrane
messages: Forms a complex with DabA.
messages: Membrane
messages: Part of an energy-coupled inorganic carbon pump.

637390:GCD22 RS14880
gene id: 637390:GCD22_RS14880
uniprot id: A0A5P9XVK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

637390:GCD22 RS17155
gene id: 637390:GCD22_RS17155
uniprot id: A0A5P9XVT2
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

637390:GCD22 RS17255
gene id: 637390:GCD22_RS17255
uniprot id: A0A5P9XVN4
names: Similarity
messages: Belongs to the TrpC family.

637390:GCD22 RS17715
gene id: 637390:GCD22_RS17715
uniprot id: A0A543Q707
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS17560
gene id: 637390:GCD22_RS17560
uniprot id: A0A543Q6W3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS06790
gene id: 637390:GCD22_RS06790
uniprot id: A0A543Q8F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS09730
gene id: 637390:GCD22_RS09730
uniprot id: A0A5P9XQM5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

637390:GCD22 RS14090
gene id: 637390:GCD22_RS14090
uniprot id: A0A5P9XUV7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16660
gene id: 637390:GCD22_RS16660
uniprot id: A0A5P9XU83
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

637390:GCD22 RS11370
gene id: 637390:GCD22_RS11370
uniprot id: A0A543Q3K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

637390:GCD22 RS01790
gene id: 637390:GCD22_RS01790
uniprot id: A0A543Q0T7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS12930
gene id: 637390:GCD22_RS12930
uniprot id: A0A5P9XT14
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17800
gene id: 637390:GCD22_RS17800
uniprot id: A0A543Q726
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

637390:GCD22 RS17465
gene id: 637390:GCD22_RS17465
uniprot id: A0A543Q6T3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

637390:GCD22 RS17755
gene id: 637390:GCD22_RS17755
uniprot id: A0A543Q6Z6
names: Caution
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05805
gene id: 637390:GCD22_RS05805
uniprot id: A0A5P9XP87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

637390:GCD22 RS04300
gene id: 637390:GCD22_RS04300
uniprot id: A0A5P9XN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

637390:GCD22 RS01770
gene id: 637390:GCD22_RS01770
uniprot id: A0A5P9XLR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

637390:GCD22 RS14080
gene id: 637390:GCD22_RS14080
uniprot id: A0A5P9XSW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

637390:GCD22 RS04765
gene id: 637390:GCD22_RS04765
uniprot id: A0A543Q034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

637390:GCD22 RS01635
gene id: 637390:GCD22_RS01635
uniprot id: A0A5P9XNZ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

637390:GCD22 RS01395
gene id: 637390:GCD22_RS01395
uniprot id: A0A5P9XM86
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

637390:GCD22 RS12965
gene id: 637390:GCD22_RS12965
uniprot id: A0A5P9XS89
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

637390:GCD22 RS17840
gene id: 637390:GCD22_RS17840
uniprot id: A0A5P9XVH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

637390:GCD22 RS09915
gene id: 637390:GCD22_RS09915
uniprot id: A0A543Q2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

637390:GCD22 RS14865
gene id: 637390:GCD22_RS14865
uniprot id: A0A5P9XV87
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

637390:GCD22 RS00300
gene id: 637390:GCD22_RS00300
uniprot id: A0A5P9XLM6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS06330
gene id: 637390:GCD22_RS06330
uniprot id: A0A5P9XNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

637390:GCD22 RS12585
gene id: 637390:GCD22_RS12585
uniprot id: A0A5P9XS24
names: Similarity
messages: Belongs to the GcvH family.

637390:GCD22 RS16670
gene id: 637390:GCD22_RS16670
uniprot id: A0A543Q638
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS06475
gene id: 637390:GCD22_RS06475
uniprot id: A0A543Q856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

637390:GCD22 RS13865
gene id: 637390:GCD22_RS13865
uniprot id: A0A5P9XTV5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

637390:GCD22 RS15400
gene id: 637390:GCD22_RS15400
uniprot id: A0A5P9XU73
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16015
gene id: 637390:GCD22_RS16015
uniprot id: A0A543Q5P5
names: Caution
names: Similarity
messages: Belongs to the band 7/mec-2 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS12135
gene id: 637390:GCD22_RS12135
uniprot id: A0A5P9XT74
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

637390:GCD22 RS05460
gene id: 637390:GCD22_RS05460
uniprot id: A0A5P9XPG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS13840
gene id: 637390:GCD22_RS13840
uniprot id: A0A5P9XU69
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS09490
gene id: 637390:GCD22_RS09490
uniprot id: A0A5P9XQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS00135
gene id: 637390:GCD22_RS00135
uniprot id: A0A5P9XLL9
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02650
gene id: 637390:GCD22_RS02650
uniprot id: A0A5P9XM52
names: Similarity
messages: Belongs to the UDPGP type 2 family.

637390:GCD22 RS00915
gene id: 637390:GCD22_RS00915
uniprot id: A0A5P9XLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

637390:GCD22 RS01370
gene id: 637390:GCD22_RS01370
uniprot id: A0A543Q0L3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

637390:GCD22 RS01225
gene id: 637390:GCD22_RS01225
uniprot id: A0A5P9XLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

637390:GCD22 RS05115
gene id: 637390:GCD22_RS05115
uniprot id: A0A543Q7F0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

637390:GCD22 RS02625
gene id: 637390:GCD22_RS02625
uniprot id: A0A5P9XM29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

637390:GCD22 RS00035
gene id: 637390:GCD22_RS00035
uniprot id: A0A543Q731
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

637390:GCD22 RS15745
gene id: 637390:GCD22_RS15745
uniprot id: A0A5P9XUC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

637390:GCD22 RS12990
gene id: 637390:GCD22_RS12990
uniprot id: A0A5P9XTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

637390:GCD22 RS17790
gene id: 637390:GCD22_RS17790
uniprot id: A0A5P9XW86
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

637390:GCD22 RS02355
gene id: 637390:GCD22_RS02355
uniprot id: A0A543Q158
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

637390:GCD22 RS05120
gene id: 637390:GCD22_RS05120
uniprot id: A0A543Q7F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

637390:GCD22 RS02775
gene id: 637390:GCD22_RS02775
uniprot id: A0A5P9XPK2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS01210
gene id: 637390:GCD22_RS01210
uniprot id: A0A5P9XMD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

637390:GCD22 RS02550
gene id: 637390:GCD22_RS02550
uniprot id: A0A5P9XM33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

637390:GCD22 RS14505
gene id: 637390:GCD22_RS14505
uniprot id: A0A543Q4L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

637390:GCD22 RS17545
gene id: 637390:GCD22_RS17545
uniprot id: A0A5P9XUK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

637390:GCD22 RS04350
gene id: 637390:GCD22_RS04350
uniprot id: A0A543PZR1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS15700
gene id: 637390:GCD22_RS15700
uniprot id: A0A5P9XV53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

637390:GCD22 RS01950
gene id: 637390:GCD22_RS01950
uniprot id: A0A543Q0X5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

637390:GCD22 RS05380
gene id: 637390:GCD22_RS05380
uniprot id: A0A543Q7J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS16460
gene id: 637390:GCD22_RS16460
uniprot id: A0A5P9XUY3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS09740
gene id: 637390:GCD22_RS09740
uniprot id: A0A5P9XSE4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

637390:GCD22 RS00925
gene id: 637390:GCD22_RS00925
uniprot id: A0A5P9XLA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

637390:GCD22 RS13800
gene id: 637390:GCD22_RS13800
uniprot id: A0A543Q478
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

637390:GCD22 RS01040
gene id: 637390:GCD22_RS01040
uniprot id: A0A5P9XN23
names: Subcellular Location Annotation
messages: Cytoplasm

637390:GCD22 RS00815
gene id: 637390:GCD22_RS00815
uniprot id: A0A543Q0B3
names: Similarity
messages: Belongs to the HesB/IscA family.

637390:GCD22 RS09755
gene id: 637390:GCD22_RS09755
uniprot id: A0A5P9XQL5
names: Similarity
messages: Belongs to the pyruvate kinase family.

637390:GCD22 RS01945
gene id: 637390:GCD22_RS01945
uniprot id: A0A5P9XNI8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

637390:GCD22 RS04745
gene id: 637390:GCD22_RS04745
uniprot id: A0A5P9XQH8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

637390:GCD22 RS04075
gene id: 637390:GCD22_RS04075
uniprot id: A0A5P9XN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

637390:GCD22 RS15065
gene id: 637390:GCD22_RS15065
uniprot id: A0A5P9XTD2
names: Similarity
messages: Belongs to the phosphoribulokinase family.

637390:GCD22 RS06525
gene id: 637390:GCD22_RS06525
uniprot id: A0A5P9XQV4
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS13850
gene id: 637390:GCD22_RS13850
uniprot id: A0A5P9XV37
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

637390:GCD22 RS10825
gene id: 637390:GCD22_RS10825
uniprot id: A0A5P9XR66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS01090
gene id: 637390:GCD22_RS01090
uniprot id: A0A5P9XLD8
names: Similarity
messages: Belongs to the group II decarboxylase family.

637390:GCD22 RS10085
gene id: 637390:GCD22_RS10085
uniprot id: A0A543Q2S6
names: Similarity
messages: Belongs to the HesB/IscA family.

637390:GCD22 RS02495
gene id: 637390:GCD22_RS02495
uniprot id: A0A543Q178
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS09820
gene id: 637390:GCD22_RS09820
uniprot id: A0A5P9XQI7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

637390:GCD22 RS06200
gene id: 637390:GCD22_RS06200
uniprot id: A0A5P9XP43
names: Similarity
messages: Belongs to the phosphohexose mutase family.

637390:GCD22 RS16085
gene id: 637390:GCD22_RS16085
uniprot id: A0A5P9XW66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

637390:GCD22 RS12590
gene id: 637390:GCD22_RS12590
uniprot id: A0A5P9XUH2
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS05160
gene id: 637390:GCD22_RS05160
uniprot id: A0A5P9XNB9
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

637390:GCD22 RS05530
gene id: 637390:GCD22_RS05530
uniprot id: A0A543Q7L6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS04255
gene id: 637390:GCD22_RS04255
uniprot id: A0A5P9XNV3
names: Similarity
messages: Belongs to the MlaA family.

637390:GCD22 RS02795
gene id: 637390:GCD22_RS02795
uniprot id: A0A543Q1C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

637390:GCD22 RS17665
gene id: 637390:GCD22_RS17665
uniprot id: A0A5P9XWP4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

637390:GCD22 RS12075
gene id: 637390:GCD22_RS12075
uniprot id: A0A5P9XT59
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

637390:GCD22 RS03680
gene id: 637390:GCD22_RS03680
uniprot id: A0A543PYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

637390:GCD22 RS10890
gene id: 637390:GCD22_RS10890
uniprot id: A0A5P9XS16
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

637390:GCD22 RS17520
gene id: 637390:GCD22_RS17520
uniprot id: A0A5P9XWW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

637390:GCD22 RS12195
gene id: 637390:GCD22_RS12195
uniprot id: A0A5P9XT82
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

637390:GCD22 RS15070
gene id: 637390:GCD22_RS15070
uniprot id: A0A5P9XU15
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

637390:GCD22 RS10140
gene id: 637390:GCD22_RS10140
uniprot id: A0A5P9XT70
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

637390:GCD22 RS06690
gene id: 637390:GCD22_RS06690
uniprot id: A0A5P9XQ90
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

637390:GCD22 RS11515
gene id: 637390:GCD22_RS11515
uniprot id: A0A5P9XSG8
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

637390:GCD22 RS16480
gene id: 637390:GCD22_RS16480
uniprot id: A0A5P9XUS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

637390:GCD22 RS02110
gene id: 637390:GCD22_RS02110
uniprot id: A0A5P9XLW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

637390:GCD22 RS03985
gene id: 637390:GCD22_RS03985
uniprot id: A0A5P9XMQ3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

637390:GCD22 RS11360
gene id: 637390:GCD22_RS11360
uniprot id: A0A5P9XTD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

637390:GCD22 RS15160
gene id: 637390:GCD22_RS15160
uniprot id: A0A543Q545
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

637390:GCD22 RS14245
gene id: 637390:GCD22_RS14245
uniprot id: A0A5P9XU18
names: Similarity
messages: Belongs to the phosphohexose mutase family.

637390:GCD22 RS11385
gene id: 637390:GCD22_RS11385
uniprot id: A0A5P9XSA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

637390:GCD22 RS00570
gene id: 637390:GCD22_RS00570
uniprot id: A0A5P9XLS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

637390:GCD22 RS17160
gene id: 637390:GCD22_RS17160
uniprot id: A0A543Q6A1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS02915
gene id: 637390:GCD22_RS02915
uniprot id: A0A5P9XMA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

637390:GCD22 RS16400
gene id: 637390:GCD22_RS16400
uniprot id: A0A5P9XTZ6
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

637390:GCD22 RS01045
gene id: 637390:GCD22_RS01045
uniprot id: A0A5P9XM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

637390:GCD22 RS05945
gene id: 637390:GCD22_RS05945
uniprot id: A0A5P9XR42
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

637390:GCD22 RS02000
gene id: 637390:GCD22_RS02000
uniprot id: A0A543Q0Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

637390:GCD22 RS00675
gene id: 637390:GCD22_RS00675
uniprot id: A0A543Q087
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS16355
gene id: 637390:GCD22_RS16355
uniprot id: A0A543Q5X6
names: Similarity
messages: Belongs to the P(II) protein family.

637390:GCD22 RS16000
gene id: 637390:GCD22_RS16000
uniprot id: A0A5P9XTS1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

637390:GCD22 RS16500
gene id: 637390:GCD22_RS16500
uniprot id: A0A5P9XWE4
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02135
gene id: 637390:GCD22_RS02135
uniprot id: A0A5P9XMN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

637390:GCD22 RS11820
gene id: 637390:GCD22_RS11820
uniprot id: A0A5P9XTL3
names: Similarity
messages: Belongs to the UPF0145 family.

637390:GCD22 RS02770
gene id: 637390:GCD22_RS02770
uniprot id: A0A5P9XM61
names: Similarity
messages: Belongs to the peptidase U62 family.

637390:GCD22 RS01470
gene id: 637390:GCD22_RS01470
uniprot id: A0A5P9XLJ2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS04810
gene id: 637390:GCD22_RS04810
uniprot id: A0A5P9XN49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

637390:GCD22 RS02675
gene id: 637390:GCD22_RS02675
uniprot id: A0A5P9XM40
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

637390:GCD22 RS01155
gene id: 637390:GCD22_RS01155
uniprot id: A0A543Q0J1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS00020
gene id: 637390:GCD22_RS00020
uniprot id: A0A5P9XKQ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

637390:GCD22 RS01430
gene id: 637390:GCD22_RS01430
uniprot id: A0A5P9XLI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

637390:GCD22 RS03790
gene id: 637390:GCD22_RS03790
uniprot id: A0A5P9XMW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS03925
gene id: 637390:GCD22_RS03925
uniprot id: A0A543PZ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

637390:GCD22 RS02035
gene id: 637390:GCD22_RS02035
uniprot id: A0A543Q0Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

637390:GCD22 RS04515
gene id: 637390:GCD22_RS04515
uniprot id: A0A543PZU0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS17335
gene id: 637390:GCD22_RS17335
uniprot id: A0A5P9XV85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS17780
gene id: 637390:GCD22_RS17780
uniprot id: A0A543Q714
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

637390:GCD22 RS01055
gene id: 637390:GCD22_RS01055
uniprot id: A0A5P9XNN7
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

637390:GCD22 RS04010
gene id: 637390:GCD22_RS04010
uniprot id: A0A5P9XN05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

637390:GCD22 RS16740
gene id: 637390:GCD22_RS16740
uniprot id: A0A5P9XU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

637390:GCD22 RS02905
gene id: 637390:GCD22_RS02905
uniprot id: A0A5P9XN03
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

637390:GCD22 RS03855
gene id: 637390:GCD22_RS03855
uniprot id: A0A5P9XNN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

637390:GCD22 RS02410
gene id: 637390:GCD22_RS02410
uniprot id: A0A5P9XMZ1
names: Similarity
messages: Belongs to the aspartokinase family.

637390:GCD22 RS03700
gene id: 637390:GCD22_RS03700
uniprot id: A0A5P9XNK9
names: Similarity
messages: Belongs to the PhoH family.

637390:GCD22 RS14380
gene id: 637390:GCD22_RS14380
uniprot id: A0A5P9XTQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

637390:GCD22 RS15175
gene id: 637390:GCD22_RS15175
uniprot id: A0A5P9XU34
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

637390:GCD22 RS15965
gene id: 637390:GCD22_RS15965
uniprot id: A0A5P9XVA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

637390:GCD22 RS02005
gene id: 637390:GCD22_RS02005
uniprot id: A0A543Q0X6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS14135
gene id: 637390:GCD22_RS14135
uniprot id: A0A5P9XTM0
names: Similarity
messages: Belongs to the RNase T2 family.

637390:GCD22 RS15820
gene id: 637390:GCD22_RS15820
uniprot id: A0A5P9XTN0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

637390:GCD22 RS04365
gene id: 637390:GCD22_RS04365
uniprot id: A0A5P9XMX9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

637390:GCD22 RS10925
gene id: 637390:GCD22_RS10925
uniprot id: A0A5P9XSH6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

637390:GCD22 RS14760
gene id: 637390:GCD22_RS14760
uniprot id: A0A543Q4W0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

637390:GCD22 RS01805
gene id: 637390:GCD22_RS01805
uniprot id: A0A543Q102
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

637390:GCD22 RS13505
gene id: 637390:GCD22_RS13505
uniprot id: A0A5P9XTQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

637390:GCD22 RS16475
gene id: 637390:GCD22_RS16475
uniprot id: A0A5P9XU06
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

637390:GCD22 RS04720
gene id: 637390:GCD22_RS04720
uniprot id: A0A5P9XN38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

637390:GCD22 RS16120
gene id: 637390:GCD22_RS16120
uniprot id: A0A543Q5T0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

637390:GCD22 RS11420
gene id: 637390:GCD22_RS11420
uniprot id: A0A543Q3L4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

637390:GCD22 RS13040
gene id: 637390:GCD22_RS13040
uniprot id: A0A543Q3T7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS14710
gene id: 637390:GCD22_RS14710
uniprot id: A0A543Q4V3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

637390:GCD22 RS11400
gene id: 637390:GCD22_RS11400
uniprot id: A0A5P9XRI6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

637390:GCD22 RS01640
gene id: 637390:GCD22_RS01640
uniprot id: A0A543Q0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

637390:GCD22 RS04305
gene id: 637390:GCD22_RS04305
uniprot id: A0A5P9XPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS13190
gene id: 637390:GCD22_RS13190
uniprot id: A0A5P9XT54
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

637390:GCD22 RS01390
gene id: 637390:GCD22_RS01390
uniprot id: A0A543Q0L5
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

637390:GCD22 RS02785
gene id: 637390:GCD22_RS02785
uniprot id: A0A5P9XMP4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

637390:GCD22 RS11220
gene id: 637390:GCD22_RS11220
uniprot id: A0A5P9XSM2
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

637390:GCD22 RS09745
gene id: 637390:GCD22_RS09745
uniprot id: A0A5P9XRU6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

637390:GCD22 RS17200
gene id: 637390:GCD22_RS17200
uniprot id: A0A543Q6C1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

637390:GCD22 RS00080
gene id: 637390:GCD22_RS00080
uniprot id: A0A5P9XLK8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

637390:GCD22 RS15150
gene id: 637390:GCD22_RS15150
uniprot id: A0A543Q532
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

637390:GCD22 RS01780
gene id: 637390:GCD22_RS01780
uniprot id: A0A5P9XMN1
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

637390:GCD22 RS17475
gene id: 637390:GCD22_RS17475
uniprot id: A0A5P9XUH7
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS01265
gene id: 637390:GCD22_RS01265
uniprot id: A0A5P9XLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

637390:GCD22 RS16470
gene id: 637390:GCD22_RS16470
uniprot id: A0A5P9XV96
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

637390:GCD22 RS01605
gene id: 637390:GCD22_RS01605
uniprot id: A0A5P9XMC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

637390:GCD22 RS09150
gene id: 637390:GCD22_RS09150
uniprot id: A0A543Q270
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS03665
gene id: 637390:GCD22_RS03665
uniprot id: A0A5P9XMJ5
names: Subcellular Location Annotation
messages: Cytoplasm

637390:GCD22 RS15075
gene id: 637390:GCD22_RS15075
uniprot id: A0A5P9XVC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

637390:GCD22 RS15655
gene id: 637390:GCD22_RS15655
uniprot id: A0A5P9XVY9
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

637390:GCD22 RS14590
gene id: 637390:GCD22_RS14590
uniprot id: A0A5P9XTT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS11345
gene id: 637390:GCD22_RS11345
uniprot id: A0A5P9XSC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

637390:GCD22 RS02260
gene id: 637390:GCD22_RS02260
uniprot id: A0A5P9XLY0
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS06680
gene id: 637390:GCD22_RS06680
uniprot id: A0A543Q8A2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS01655
gene id: 637390:GCD22_RS01655
uniprot id: A0A543Q0X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

637390:GCD22 RS10995
gene id: 637390:GCD22_RS10995
uniprot id: A0A5P9XS35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS11440
gene id: 637390:GCD22_RS11440
uniprot id: A0A5P9XSC0
names: Similarity
messages: Belongs to the ParB family.

637390:GCD22 RS00240
gene id: 637390:GCD22_RS00240
uniprot id: A0A5P9XKV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

637390:GCD22 RS10205
gene id: 637390:GCD22_RS10205
uniprot id: A0A5P9XRK0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS01795
gene id: 637390:GCD22_RS01795
uniprot id: A0A5P9XM77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

637390:GCD22 RS03990
gene id: 637390:GCD22_RS03990
uniprot id: A0A543PZ66
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

637390:GCD22 RS16835
gene id: 637390:GCD22_RS16835
uniprot id: A0A5P9XVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

637390:GCD22 RS16455
gene id: 637390:GCD22_RS16455
uniprot id: A0A5P9XU02
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS11010
gene id: 637390:GCD22_RS11010
uniprot id: A0A5P9XS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS04390
gene id: 637390:GCD22_RS04390
uniprot id: A0A5P9XNR6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

637390:GCD22 RS11415
gene id: 637390:GCD22_RS11415
uniprot id: A0A5P9XSU0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

637390:GCD22 RS03850
gene id: 637390:GCD22_RS03850
uniprot id: A0A5P9XPF4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS05870
gene id: 637390:GCD22_RS05870
uniprot id: A0A5P9XNP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

637390:GCD22 RS05025
gene id: 637390:GCD22_RS05025
uniprot id: A0A543Q7D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

637390:GCD22 RS04960
gene id: 637390:GCD22_RS04960
uniprot id: A0A5P9XQ09
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

637390:GCD22 RS05875
gene id: 637390:GCD22_RS05875
uniprot id: A0A5P9XNY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

637390:GCD22 RS05450
gene id: 637390:GCD22_RS05450
uniprot id: A0A543Q7K9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS01685
gene id: 637390:GCD22_RS01685
uniprot id: A0A543Q0S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

637390:GCD22 RS06220
gene id: 637390:GCD22_RS06220
uniprot id: A0A5P9XNX2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

637390:GCD22 RS05670
gene id: 637390:GCD22_RS05670
uniprot id: A0A543Q7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS15600
gene id: 637390:GCD22_RS15600
uniprot id: A0A543Q5H3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS15140
gene id: 637390:GCD22_RS15140
uniprot id: A0A5P9XTD6
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

637390:GCD22 RS15750
gene id: 637390:GCD22_RS15750
uniprot id: A0A5P9XVN3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

637390:GCD22 RS05790
gene id: 637390:GCD22_RS05790
uniprot id: A0A543Q7R6
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

637390:GCD22 RS00250
gene id: 637390:GCD22_RS00250
uniprot id: A0A5P9XMM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

637390:GCD22 RS14570
gene id: 637390:GCD22_RS14570
uniprot id: A0A5P9XTW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

637390:GCD22 RS13845
gene id: 637390:GCD22_RS13845
uniprot id: A0A543Q4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

637390:GCD22 RS15845
gene id: 637390:GCD22_RS15845
uniprot id: A0A543Q5L6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

637390:GCD22 RS02810
gene id: 637390:GCD22_RS02810
uniprot id: A0A543Q1E2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

637390:GCD22 RS02230
gene id: 637390:GCD22_RS02230
uniprot id: A0A5P9XPB2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

637390:GCD22 RS01425
gene id: 637390:GCD22_RS01425
uniprot id: A0A5P9XNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein.

637390:GCD22 RS12595
gene id: 637390:GCD22_RS12595
uniprot id: A0A5P9XRX6
names: Similarity
messages: Belongs to the ParB family.

637390:GCD22 RS04795
gene id: 637390:GCD22_RS04795
uniprot id: A0A5P9XP47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

637390:GCD22 RS17725
gene id: 637390:GCD22_RS17725
uniprot id: A0A5P9XW77
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

637390:GCD22 RS04675
gene id: 637390:GCD22_RS04675
uniprot id: A0A5P9XPW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

637390:GCD22 RS06255
gene id: 637390:GCD22_RS06255
uniprot id: A0A543Q850
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17765
gene id: 637390:GCD22_RS17765
uniprot id: A0A543Q6Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS15650
gene id: 637390:GCD22_RS15650
uniprot id: A0A5P9XTM2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS05475
gene id: 637390:GCD22_RS05475
uniprot id: A0A5P9XNF5
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

637390:GCD22 RS01455
gene id: 637390:GCD22_RS01455
uniprot id: A0A5P9XLK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

637390:GCD22 RS10090
gene id: 637390:GCD22_RS10090
uniprot id: A0A5P9XQN6
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

637390:GCD22 RS09965
gene id: 637390:GCD22_RS09965
uniprot id: A0A5P9XSI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

637390:GCD22 RS01850
gene id: 637390:GCD22_RS01850
uniprot id: A0A5P9XM87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

637390:GCD22 RS17795
gene id: 637390:GCD22_RS17795
uniprot id: A0A543Q704
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

637390:GCD22 RS02605
gene id: 637390:GCD22_RS02605
uniprot id: A0A5P9XNU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

637390:GCD22 RS05735
gene id: 637390:GCD22_RS05735
uniprot id: A0A5P9XPM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheZ family.
messages: Cytoplasm

637390:GCD22 RS13080
gene id: 637390:GCD22_RS13080
uniprot id: A0A543Q3U7
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

637390:GCD22 RS00005
gene id: 637390:GCD22_RS00005
uniprot id: A0A5P9XLN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

637390:GCD22 RS04540
gene id: 637390:GCD22_RS04540
uniprot id: A0A543PZU5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS11405
gene id: 637390:GCD22_RS11405
uniprot id: A0A5P9XS08
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

637390:GCD22 RS06605
gene id: 637390:GCD22_RS06605
uniprot id: A0A5P9XRG8
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

637390:GCD22 RS00065
gene id: 637390:GCD22_RS00065
uniprot id: A0A5P9XN62
names: Similarity
messages: Belongs to the DprA/Smf family.

637390:GCD22 RS10310
gene id: 637390:GCD22_RS10310
uniprot id: A0A5P9XRM3
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17500
gene id: 637390:GCD22_RS17500
uniprot id: A0A543Q6U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

637390:GCD22 RS03900
gene id: 637390:GCD22_RS03900
uniprot id: A0A5P9XPG1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS03195
gene id: 637390:GCD22_RS03195
uniprot id: A0A5P9XNC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

637390:GCD22 RS04630
gene id: 637390:GCD22_RS04630
uniprot id: A0A5P9XN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS09970
gene id: 637390:GCD22_RS09970
uniprot id: A0A5P9XRY7
names: Similarity
messages: Belongs to the Skp family.

637390:GCD22 RS02370
gene id: 637390:GCD22_RS02370
uniprot id: A0A5P9XPC9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

637390:GCD22 RS01185
gene id: 637390:GCD22_RS01185
uniprot id: A0A5P9XM76
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS17620
gene id: 637390:GCD22_RS17620
uniprot id: A0A5P9XWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

637390:GCD22 RS17380
gene id: 637390:GCD22_RS17380
uniprot id: A0A5P9XVW8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

637390:GCD22 RS02640
gene id: 637390:GCD22_RS02640
uniprot id: A0A5P9XMV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

637390:GCD22 RS17535
gene id: 637390:GCD22_RS17535
uniprot id: A0A5P9XVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

637390:GCD22 RS02430
gene id: 637390:GCD22_RS02430
uniprot id: A0A5P9XMI3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

637390:GCD22 RS17815
gene id: 637390:GCD22_RS17815
uniprot id: A0A543Q706
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS13010
gene id: 637390:GCD22_RS13010
uniprot id: A0A543Q3S4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS00075
gene id: 637390:GCD22_RS00075
uniprot id: A0A5P9XL94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

637390:GCD22 RS05010
gene id: 637390:GCD22_RS05010
uniprot id: A0A543Q7D1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

637390:GCD22 RS05495
gene id: 637390:GCD22_RS05495
uniprot id: A0A5P9XNG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

637390:GCD22 RS01715
gene id: 637390:GCD22_RS01715
uniprot id: A0A5P9XLN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

637390:GCD22 RS01835
gene id: 637390:GCD22_RS01835
uniprot id: A0A5P9XLQ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

637390:GCD22 RS01985
gene id: 637390:GCD22_RS01985
uniprot id: A0A543Q0X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

637390:GCD22 RS09415
gene id: 637390:GCD22_RS09415
uniprot id: A0A5P9XRK1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS05505
gene id: 637390:GCD22_RS05505
uniprot id: A0A5P9XQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

637390:GCD22 RS02030
gene id: 637390:GCD22_RS02030
uniprot id: A0A5P9XMK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

637390:GCD22 RS11295
gene id: 637390:GCD22_RS11295
uniprot id: A0A5P9XRY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

637390:GCD22 RS03875
gene id: 637390:GCD22_RS03875
uniprot id: A0A5P9XN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS17250
gene id: 637390:GCD22_RS17250
uniprot id: A0A5P9XVD2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

637390:GCD22 RS11480
gene id: 637390:GCD22_RS11480
uniprot id: A0A543Q1L6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS16585
gene id: 637390:GCD22_RS16585
uniprot id: A0A5P9XVH0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

637390:GCD22 RS02760
gene id: 637390:GCD22_RS02760
uniprot id: A0A5P9XNX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

637390:GCD22 RS03830
gene id: 637390:GCD22_RS03830
uniprot id: A0A5P9XNH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

637390:GCD22 RS05030
gene id: 637390:GCD22_RS05030
uniprot id: A0A543Q7E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

637390:GCD22 RS10835
gene id: 637390:GCD22_RS10835
uniprot id: A0A5P9XR25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

637390:GCD22 RS15815
gene id: 637390:GCD22_RS15815
uniprot id: A0A5P9XW20
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

637390:GCD22 RS00355
gene id: 637390:GCD22_RS00355
uniprot id: A0A5P9XLN6
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

637390:GCD22 RS02170
gene id: 637390:GCD22_RS02170
uniprot id: A0A5P9XPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

637390:GCD22 RS11205
gene id: 637390:GCD22_RS11205
uniprot id: A0A5P9XTR7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS09690
gene id: 637390:GCD22_RS09690
uniprot id: A0A5P9XRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

637390:GCD22 RS02215
gene id: 637390:GCD22_RS02215
uniprot id: A0A5P9XNP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

637390:GCD22 RS06585
gene id: 637390:GCD22_RS06585
uniprot id: A0A5P9XPB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

637390:GCD22 RS16430
gene id: 637390:GCD22_RS16430
uniprot id: A0A5P9XW13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TolB family.
messages: Periplasm

637390:GCD22 RS05395
gene id: 637390:GCD22_RS05395
uniprot id: A0A543Q7J2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS05925
gene id: 637390:GCD22_RS05925
uniprot id: A0A5P9XP02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

637390:GCD22 RS14155
gene id: 637390:GCD22_RS14155
uniprot id: A0A543Q4G9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS15930
gene id: 637390:GCD22_RS15930
uniprot id: A0A5P9XTP5
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

637390:GCD22 RS16920
gene id: 637390:GCD22_RS16920
uniprot id: A0A5P9XVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

637390:GCD22 RS02075
gene id: 637390:GCD22_RS02075
uniprot id: A0A5P9XMC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

637390:GCD22 RS00900
gene id: 637390:GCD22_RS00900
uniprot id: A0A5P9XL88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

637390:GCD22 RS12350
gene id: 637390:GCD22_RS12350
uniprot id: A0A5P9XTY8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

637390:GCD22 RS01890
gene id: 637390:GCD22_RS01890
uniprot id: A0A5P9XP51
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

637390:GCD22 RS00565
gene id: 637390:GCD22_RS00565
uniprot id: A0A543Q065
names: Similarity
messages: Belongs to the LOG family.

637390:GCD22 RS12315
gene id: 637390:GCD22_RS12315
uniprot id: A0A5P9XUC6
names: Similarity
messages: Belongs to the PspA/IM30 family.

637390:GCD22 RS06305
gene id: 637390:GCD22_RS06305
uniprot id: A0A5P9XP58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

637390:GCD22 RS05695
gene id: 637390:GCD22_RS05695
uniprot id: A0A543Q7P5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

637390:GCD22 RS04785
gene id: 637390:GCD22_RS04785
uniprot id: A0A543Q052
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

637390:GCD22 RS09770
gene id: 637390:GCD22_RS09770
uniprot id: A0A5P9XQH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

637390:GCD22 RS00555
gene id: 637390:GCD22_RS00555
uniprot id: A0A5P9XL23
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

637390:GCD22 RS00955
gene id: 637390:GCD22_RS00955
uniprot id: A0A5P9XL98
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

637390:GCD22 RS01930
gene id: 637390:GCD22_RS01930
uniprot id: A0A5P9XLS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

637390:GCD22 RS15480
gene id: 637390:GCD22_RS15480
uniprot id: A0A5P9XVW0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

637390:GCD22 RS11300
gene id: 637390:GCD22_RS11300
uniprot id: A0A5P9XTB7
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

637390:GCD22 RS16035
gene id: 637390:GCD22_RS16035
uniprot id: A0A5P9XTR4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

637390:GCD22 RS08755
gene id: 637390:GCD22_RS08755
uniprot id: A0A543Q214
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

637390:GCD22 RS01530
gene id: 637390:GCD22_RS01530
uniprot id: A0A5P9XLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

637390:GCD22 RS11060
gene id: 637390:GCD22_RS11060
uniprot id: A0A5P9XSJ5
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

637390:GCD22 RS13480
gene id: 637390:GCD22_RS13480
uniprot id: A0A543Q423
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

637390:GCD22 RS10095
gene id: 637390:GCD22_RS10095
uniprot id: A0A5P9XRI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

637390:GCD22 RS04370
gene id: 637390:GCD22_RS04370
uniprot id: A0A5P9XQA4
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS16255
gene id: 637390:GCD22_RS16255
uniprot id: A0A5P9XUT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

637390:GCD22 RS17105
gene id: 637390:GCD22_RS17105
uniprot id: A0A5P9XVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

637390:GCD22 RS14025
gene id: 637390:GCD22_RS14025
uniprot id: A0A5P9XTZ3
names: Subcellular Location Annotation
messages: Membrane

637390:GCD22 RS02350
gene id: 637390:GCD22_RS02350
uniprot id: A0A5P9XNQ5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

637390:GCD22 RS02575
gene id: 637390:GCD22_RS02575
uniprot id: A0A5P9XM20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.