632348:CALKRO RS04570
gene id: 632348:CALKRO_RS04570
uniprot id: E4SDH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

632348:CALKRO RS07520
gene id: 632348:CALKRO_RS07520
uniprot id: E4SF17
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

632348:CALKRO RS11195
gene id: 632348:CALKRO_RS11195
uniprot id: E4SH27
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

632348:CALKRO RS06520
gene id: 632348:CALKRO_RS06520
uniprot id: E4SBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

632348:CALKRO RS02530
gene id: 632348:CALKRO_RS02530
uniprot id: E4SEB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

632348:CALKRO RS01985
gene id: 632348:CALKRO_RS01985
uniprot id: E4SE08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS04945
gene id: 632348:CALKRO_RS04945
uniprot id: E4SB78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

632348:CALKRO RS07115
gene id: 632348:CALKRO_RS07115
uniprot id: E4SBY9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

632348:CALKRO RS09975
gene id: 632348:CALKRO_RS09975
uniprot id: E4SGE0
names: Similarity
messages: Belongs to the threonine synthase family.

632348:CALKRO RS09275
gene id: 632348:CALKRO_RS09275
uniprot id: E4SG11
names: Similarity
messages: Belongs to the IMPACT family.

632348:CALKRO RS06605
gene id: 632348:CALKRO_RS06605
uniprot id: E4SBP0
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

632348:CALKRO RS09495
gene id: 632348:CALKRO_RS09495
uniprot id: E4SG55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

632348:CALKRO RS06505
gene id: 632348:CALKRO_RS06505
uniprot id: E4SBM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

632348:CALKRO RS09530
gene id: 632348:CALKRO_RS09530
uniprot id: E4SG62
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

632348:CALKRO RS08445
gene id: 632348:CALKRO_RS08445
uniprot id: E4SFJ8
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

632348:CALKRO RS11830
gene id: 632348:CALKRO_RS11830
uniprot id: E4SHE2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

632348:CALKRO RS02895
gene id: 632348:CALKRO_RS02895
uniprot id: E4SEI0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

632348:CALKRO RS07070
gene id: 632348:CALKRO_RS07070
uniprot id: E4SBY0
names: Similarity
messages: Belongs to the class-D beta-lactamase family.
messages: Belongs to the transpeptidase family.

632348:CALKRO RS05980
gene id: 632348:CALKRO_RS05980
uniprot id: E4SD28
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

632348:CALKRO RS06430
gene id: 632348:CALKRO_RS06430
uniprot id: E4SBK5
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

632348:CALKRO RS01110
gene id: 632348:CALKRO_RS01110
uniprot id: E4SD75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS12280
gene id: 632348:CALKRO_RS12280
uniprot id: E4SHM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

632348:CALKRO RS01525
gene id: 632348:CALKRO_RS01525
uniprot id: E4SDL9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS09110
gene id: 632348:CALKRO_RS09110
uniprot id: E4SFX8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

632348:CALKRO RS01085
gene id: 632348:CALKRO_RS01085
uniprot id: E4SD70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05380
gene id: 632348:CALKRO_RS05380
uniprot id: E4SCK2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

632348:CALKRO RS06095
gene id: 632348:CALKRO_RS06095
uniprot id: E4SBD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

632348:CALKRO RS08140
gene id: 632348:CALKRO_RS08140
uniprot id: E4SFD8
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05405
gene id: 632348:CALKRO_RS05405
uniprot id: E4SCK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

632348:CALKRO RS07725
gene id: 632348:CALKRO_RS07725
uniprot id: E4SF58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

632348:CALKRO RS02935
gene id: 632348:CALKRO_RS02935
uniprot id: E4SEI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

632348:CALKRO RS08340
gene id: 632348:CALKRO_RS08340
uniprot id: E4SFH8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

632348:CALKRO RS04500
gene id: 632348:CALKRO_RS04500
uniprot id: E4SDG2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS03165
gene id: 632348:CALKRO_RS03165
uniprot id: E4SEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04145
gene id: 632348:CALKRO_RS04145
uniprot id: E4SB50
names: Similarity
messages: Belongs to the peptidase C40 family.

632348:CALKRO RS05875
gene id: 632348:CALKRO_RS05875
uniprot id: E4SD10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

632348:CALKRO RS11835
gene id: 632348:CALKRO_RS11835
uniprot id: E4SHE3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

632348:CALKRO RS09730
gene id: 632348:CALKRO_RS09730
uniprot id: E4SG93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

632348:CALKRO RS07455
gene id: 632348:CALKRO_RS07455
uniprot id: E4SC94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

632348:CALKRO RS11000
gene id: 632348:CALKRO_RS11000
uniprot id: E4SGZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

632348:CALKRO RS09665
gene id: 632348:CALKRO_RS09665
uniprot id: E4SG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08375
gene id: 632348:CALKRO_RS08375
uniprot id: E4SFI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

632348:CALKRO RS08625
gene id: 632348:CALKRO_RS08625
uniprot id: E4SFN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

632348:CALKRO RS10440
gene id: 632348:CALKRO_RS10440
uniprot id: E4SGN1
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS03765
gene id: 632348:CALKRO_RS03765
uniprot id: E4SEZ9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

632348:CALKRO RS08585
gene id: 632348:CALKRO_RS08585
uniprot id: E4SFM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

632348:CALKRO RS10270
gene id: 632348:CALKRO_RS10270
uniprot id: E4SGJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS11770
gene id: 632348:CALKRO_RS11770
uniprot id: E4SHD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

632348:CALKRO RS09940
gene id: 632348:CALKRO_RS09940
uniprot id: E4SGD4
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

632348:CALKRO RS04695
gene id: 632348:CALKRO_RS04695
uniprot id: E4SDQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

632348:CALKRO RS00520
gene id: 632348:CALKRO_RS00520
uniprot id: E4SCG6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

632348:CALKRO RS08590
gene id: 632348:CALKRO_RS08590
uniprot id: E4SFM7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

632348:CALKRO RS00805
gene id: 632348:CALKRO_RS00805
uniprot id: E4SCU4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS12445
gene id: 632348:CALKRO_RS12445
uniprot id: E4SHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07920
gene id: 632348:CALKRO_RS07920
uniprot id: E4SF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

632348:CALKRO RS09865
gene id: 632348:CALKRO_RS09865
uniprot id: E4SGB9
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

632348:CALKRO RS02575
gene id: 632348:CALKRO_RS02575
uniprot id: E4SEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

632348:CALKRO RS02265
gene id: 632348:CALKRO_RS02265
uniprot id: E4SE58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08810
gene id: 632348:CALKRO_RS08810
uniprot id: E4SFS2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

632348:CALKRO RS00350
gene id: 632348:CALKRO_RS00350
uniprot id: E4SCD2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS03740
gene id: 632348:CALKRO_RS03740
uniprot id: E4SEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS03615
gene id: 632348:CALKRO_RS03615
uniprot id: E4SEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

632348:CALKRO RS04895
gene id: 632348:CALKRO_RS04895
uniprot id: E4SB68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

632348:CALKRO RS07470
gene id: 632348:CALKRO_RS07470
uniprot id: E4SC97
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

632348:CALKRO RS12360
gene id: 632348:CALKRO_RS12360
uniprot id: E4SHN7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

632348:CALKRO RS09550
gene id: 632348:CALKRO_RS09550
uniprot id: E4SG66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

632348:CALKRO RS02695
gene id: 632348:CALKRO_RS02695
uniprot id: E4SEE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

632348:CALKRO RS06425
gene id: 632348:CALKRO_RS06425
uniprot id: E4SBK4
names: Similarity
messages: Belongs to the GARS family.

632348:CALKRO RS02980
gene id: 632348:CALKRO_RS02980
uniprot id: E4SEJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05355
gene id: 632348:CALKRO_RS05355
uniprot id: E4SCJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

632348:CALKRO RS02410
gene id: 632348:CALKRO_RS02410
uniprot id: E4SE87
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

632348:CALKRO RS10940
gene id: 632348:CALKRO_RS10940
uniprot id: E4SGX8
names: Similarity
messages: Belongs to the glycosyl hydrolase.

632348:CALKRO RS07900
gene id: 632348:CALKRO_RS07900
uniprot id: E4SF91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

632348:CALKRO RS00720
gene id: 632348:CALKRO_RS00720
uniprot id: E4SCS7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

632348:CALKRO RS04025
gene id: 632348:CALKRO_RS04025
uniprot id: E4SB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS12995
gene id: 632348:CALKRO_RS12995
uniprot id: E4SI02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

632348:CALKRO RS10470
gene id: 632348:CALKRO_RS10470
uniprot id: E4SGN8
names: Function
names: Similarity
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

632348:CALKRO RS09235
gene id: 632348:CALKRO_RS09235
uniprot id: E4SG03
names: Similarity
messages: Belongs to the AOR/FOR family.

632348:CALKRO RS04460
gene id: 632348:CALKRO_RS04460
uniprot id: E4SDF4
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

632348:CALKRO RS04710
gene id: 632348:CALKRO_RS04710
uniprot id: E4SDR2
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

632348:CALKRO RS08200
gene id: 632348:CALKRO_RS08200
uniprot id: E4SFF0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

632348:CALKRO RS03045
gene id: 632348:CALKRO_RS03045
uniprot id: E4SEL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS06220
gene id: 632348:CALKRO_RS06220
uniprot id: E4SBG3
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00370
gene id: 632348:CALKRO_RS00370
uniprot id: E4SCD6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS12945
gene id: 632348:CALKRO_RS12945
uniprot id: E4SHZ2
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS07170
gene id: 632348:CALKRO_RS07170
uniprot id: E4SC37
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

632348:CALKRO RS10775
gene id: 632348:CALKRO_RS10775
uniprot id: E4SGU6
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

632348:CALKRO RS12310
gene id: 632348:CALKRO_RS12310
uniprot id: E4SHM7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

632348:CALKRO RS07930
gene id: 632348:CALKRO_RS07930
uniprot id: E4SF97
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS07595
gene id: 632348:CALKRO_RS07595
uniprot id: E4SF32
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

632348:CALKRO RS06265
gene id: 632348:CALKRO_RS06265
uniprot id: E4SBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

632348:CALKRO RS01435
gene id: 632348:CALKRO_RS01435
uniprot id: E4SDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

632348:CALKRO RS03360
gene id: 632348:CALKRO_RS03360
uniprot id: E4SES2
names: Similarity
messages: Belongs to the GSP E family.

632348:CALKRO RS08660
gene id: 632348:CALKRO_RS08660
uniprot id: E4SFP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

632348:CALKRO RS01205
gene id: 632348:CALKRO_RS01205
uniprot id: E4SD94
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

632348:CALKRO RS09425
gene id: 632348:CALKRO_RS09425
uniprot id: E4SG41
names: Similarity
messages: Belongs to the UPF0749 family.

632348:CALKRO RS00820
gene id: 632348:CALKRO_RS00820
uniprot id: E4SCU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

632348:CALKRO RS06125
gene id: 632348:CALKRO_RS06125
uniprot id: E4SBE4
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

632348:CALKRO RS10035
gene id: 632348:CALKRO_RS10035
uniprot id: E4SGF2
names: Similarity
messages: Belongs to the glutamine synthetase family.

632348:CALKRO RS00760
gene id: 632348:CALKRO_RS00760
uniprot id: E4SCT5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

632348:CALKRO RS01980
gene id: 632348:CALKRO_RS01980
uniprot id: E4SE07
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

632348:CALKRO RS11365
gene id: 632348:CALKRO_RS11365
uniprot id: E4SH56
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS04615
gene id: 632348:CALKRO_RS04615
uniprot id: E4SDP3
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

632348:CALKRO RS11460
gene id: 632348:CALKRO_RS11460
uniprot id: E4SH73
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

632348:CALKRO RS10745
gene id: 632348:CALKRO_RS10745
uniprot id: E4SGU0
names: Similarity
messages: Belongs to the P(II) protein family.

632348:CALKRO RS07440
gene id: 632348:CALKRO_RS07440
uniprot id: E4SC91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS04020
gene id: 632348:CALKRO_RS04020
uniprot id: E4SB24
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

632348:CALKRO RS04675
gene id: 632348:CALKRO_RS04675
uniprot id: E4SDQ5
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS08295
gene id: 632348:CALKRO_RS08295
uniprot id: E4SFG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

632348:CALKRO RS04455
gene id: 632348:CALKRO_RS04455
uniprot id: E4SDF3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

632348:CALKRO RS12045
gene id: 632348:CALKRO_RS12045
uniprot id: E4SHI3
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

632348:CALKRO RS02625
gene id: 632348:CALKRO_RS02625
uniprot id: E4SED0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS01045
gene id: 632348:CALKRO_RS01045
uniprot id: E4SD62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

632348:CALKRO RS04870
gene id: 632348:CALKRO_RS04870
uniprot id: E4SB63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

632348:CALKRO RS08190
gene id: 632348:CALKRO_RS08190
uniprot id: E4SFE8
names: Similarity
messages: Belongs to the MotB family.

632348:CALKRO RS08205
gene id: 632348:CALKRO_RS08205
uniprot id: E4SFF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

632348:CALKRO RS03730
gene id: 632348:CALKRO_RS03730
uniprot id: E4SEZ2
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

632348:CALKRO RS01835
gene id: 632348:CALKRO_RS01835
uniprot id: E4SDX8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS10825
gene id: 632348:CALKRO_RS10825
uniprot id: E4SGV6
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

632348:CALKRO RS07530
gene id: 632348:CALKRO_RS07530
uniprot id: E4SF19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

632348:CALKRO RS08020
gene id: 632348:CALKRO_RS08020
uniprot id: E4SFB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

632348:CALKRO RS06285
gene id: 632348:CALKRO_RS06285
uniprot id: E4SBH6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

632348:CALKRO RS11965
gene id: 632348:CALKRO_RS11965
uniprot id: E4SHG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS09480
gene id: 632348:CALKRO_RS09480
uniprot id: E4SG52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

632348:CALKRO RS08275
gene id: 632348:CALKRO_RS08275
uniprot id: E4SFG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

632348:CALKRO RS05765
gene id: 632348:CALKRO_RS05765
uniprot id: E4SCZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

632348:CALKRO RS10260
gene id: 632348:CALKRO_RS10260
uniprot id: E4SGJ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

632348:CALKRO RS09265
gene id: 632348:CALKRO_RS09265
uniprot id: E4SG09
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05240
gene id: 632348:CALKRO_RS05240
uniprot id: E4SCH6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

632348:CALKRO RS11120
gene id: 632348:CALKRO_RS11120
uniprot id: E4SH11
names: Similarity
messages: Belongs to the sigma-70 factor family.

632348:CALKRO RS10475
gene id: 632348:CALKRO_RS10475
uniprot id: E4SGN9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

632348:CALKRO RS08380
gene id: 632348:CALKRO_RS08380
uniprot id: E4SFI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

632348:CALKRO RS11670
gene id: 632348:CALKRO_RS11670
uniprot id: E4SHB1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS02605
gene id: 632348:CALKRO_RS02605
uniprot id: E4SEC6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

632348:CALKRO RS02690
gene id: 632348:CALKRO_RS02690
uniprot id: E4SEE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

632348:CALKRO RS02590
gene id: 632348:CALKRO_RS02590
uniprot id: E4SEC3
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

632348:CALKRO RS08355
gene id: 632348:CALKRO_RS08355
uniprot id: E4SFI1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

632348:CALKRO RS01840
gene id: 632348:CALKRO_RS01840
uniprot id: E4SDX9
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

632348:CALKRO RS05100
gene id: 632348:CALKRO_RS05100
uniprot id: E4SBA2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

632348:CALKRO RS09980
gene id: 632348:CALKRO_RS09980
uniprot id: E4SGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

632348:CALKRO RS09150
gene id: 632348:CALKRO_RS09150
uniprot id: E4SFY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

632348:CALKRO RS03595
gene id: 632348:CALKRO_RS03595
uniprot id: E4SEW7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

632348:CALKRO RS02610
gene id: 632348:CALKRO_RS02610
uniprot id: E4SEC7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

632348:CALKRO RS11715
gene id: 632348:CALKRO_RS11715
uniprot id: E4SHC0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

632348:CALKRO RS02305
gene id: 632348:CALKRO_RS02305
uniprot id: E4SE66
names: Similarity
messages: Belongs to the DprA/Smf family.

632348:CALKRO RS06280
gene id: 632348:CALKRO_RS06280
uniprot id: E4SBH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

632348:CALKRO RS04385
gene id: 632348:CALKRO_RS04385
uniprot id: E4SDD9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

632348:CALKRO RS07915
gene id: 632348:CALKRO_RS07915
uniprot id: E4SF94
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

632348:CALKRO RS00705
gene id: 632348:CALKRO_RS00705
uniprot id: E4SCS4
names: Similarity
messages: Belongs to the FGGY kinase family.

632348:CALKRO RS04645
gene id: 632348:CALKRO_RS04645
uniprot id: E4SDP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

632348:CALKRO RS00490
gene id: 632348:CALKRO_RS00490
uniprot id: E4SCG0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS08565
gene id: 632348:CALKRO_RS08565
uniprot id: E4SFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

632348:CALKRO RS03320
gene id: 632348:CALKRO_RS03320
uniprot id: E4SER5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

632348:CALKRO RS11080
gene id: 632348:CALKRO_RS11080
uniprot id: E4SH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

632348:CALKRO RS10730
gene id: 632348:CALKRO_RS10730
uniprot id: E4SGT7
names: Similarity
messages: Belongs to the P(II) protein family.

632348:CALKRO RS04510
gene id: 632348:CALKRO_RS04510
uniprot id: E4SDG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

632348:CALKRO RS06935
gene id: 632348:CALKRO_RS06935
uniprot id: E4SBV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS08315
gene id: 632348:CALKRO_RS08315
uniprot id: E4SFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

632348:CALKRO RS00650
gene id: 632348:CALKRO_RS00650
uniprot id: E4SCR4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

632348:CALKRO RS08320
gene id: 632348:CALKRO_RS08320
uniprot id: E4SFH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

632348:CALKRO RS02835
gene id: 632348:CALKRO_RS02835
uniprot id: E4SEG9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

632348:CALKRO RS02455
gene id: 632348:CALKRO_RS02455
uniprot id: E4SE96
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

632348:CALKRO RS02710
gene id: 632348:CALKRO_RS02710
uniprot id: E4SEE7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

632348:CALKRO RS04410
gene id: 632348:CALKRO_RS04410
uniprot id: E4SDE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

632348:CALKRO RS08110
gene id: 632348:CALKRO_RS08110
uniprot id: E4SFD2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

632348:CALKRO RS08185
gene id: 632348:CALKRO_RS08185
uniprot id: E4SFE7
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS03700
gene id: 632348:CALKRO_RS03700
uniprot id: E4SEY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

632348:CALKRO RS07090
gene id: 632348:CALKRO_RS07090
uniprot id: E4SBY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

632348:CALKRO RS06455
gene id: 632348:CALKRO_RS06455
uniprot id: E4SBL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

632348:CALKRO RS09805
gene id: 632348:CALKRO_RS09805
uniprot id: E4SGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

632348:CALKRO RS12575
gene id: 632348:CALKRO_RS12575
uniprot id: E4SHT0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

632348:CALKRO RS00500
gene id: 632348:CALKRO_RS00500
uniprot id: E4SCG2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

632348:CALKRO RS04420
gene id: 632348:CALKRO_RS04420
uniprot id: E4SDE6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

632348:CALKRO RS02350
gene id: 632348:CALKRO_RS02350
uniprot id: E4SE75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

632348:CALKRO RS00475
gene id: 632348:CALKRO_RS00475
uniprot id: E4SCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01640
gene id: 632348:CALKRO_RS01640
uniprot id: E4SDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04505
gene id: 632348:CALKRO_RS04505
uniprot id: E4SDG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

632348:CALKRO RS07720
gene id: 632348:CALKRO_RS07720
uniprot id: E4SF57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

632348:CALKRO RS12085
gene id: 632348:CALKRO_RS12085
uniprot id: E4SHJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07340
gene id: 632348:CALKRO_RS07340
uniprot id: E4SC71
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

632348:CALKRO RS08575
gene id: 632348:CALKRO_RS08575
uniprot id: E4SFM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

632348:CALKRO RS12540
gene id: 632348:CALKRO_RS12540
uniprot id: E4SHS3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

632348:CALKRO RS06765
gene id: 632348:CALKRO_RS06765
uniprot id: E4SBR9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

632348:CALKRO RS05840
gene id: 632348:CALKRO_RS05840
uniprot id: E4SD03
names: Similarity
messages: Belongs to the CapA family.

632348:CALKRO RS12965
gene id: 632348:CALKRO_RS12965
uniprot id: E4SHZ6
names: Similarity
messages: Belongs to the ParB family.

632348:CALKRO RS07485
gene id: 632348:CALKRO_RS07485
uniprot id: E4SCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

632348:CALKRO RS08215
gene id: 632348:CALKRO_RS08215
uniprot id: E4SFF3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

632348:CALKRO RS10370
gene id: 632348:CALKRO_RS10370
uniprot id: E4SGL7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS12495
gene id: 632348:CALKRO_RS12495
uniprot id: E4SHR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09825
gene id: 632348:CALKRO_RS09825
uniprot id: E4SGB2
names: Similarity
messages: Belongs to the RecJ family.

632348:CALKRO RS01735
gene id: 632348:CALKRO_RS01735
uniprot id: E4SDV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

632348:CALKRO RS11430
gene id: 632348:CALKRO_RS11430
uniprot id: E4SH67
names: Function
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

632348:CALKRO RS06195
gene id: 632348:CALKRO_RS06195
uniprot id: E4SBF8
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

632348:CALKRO RS07755
gene id: 632348:CALKRO_RS07755
uniprot id: E4SF63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

632348:CALKRO RS03060
gene id: 632348:CALKRO_RS03060
uniprot id: E4SEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

632348:CALKRO RS04620
gene id: 632348:CALKRO_RS04620
uniprot id: E4SDP4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

632348:CALKRO RS03710
gene id: 632348:CALKRO_RS03710
uniprot id: E4SEY8
names: Similarity
messages: Belongs to the UPF0735 family.

632348:CALKRO RS11295
gene id: 632348:CALKRO_RS11295
uniprot id: E4SH47
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

632348:CALKRO RS02170
gene id: 632348:CALKRO_RS02170
uniprot id: E4SE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS11095
gene id: 632348:CALKRO_RS11095
uniprot id: E4SH08
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

632348:CALKRO RS13035
gene id: 632348:CALKRO_RS13035
uniprot id: E4SI10
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

632348:CALKRO RS01235
gene id: 632348:CALKRO_RS01235
uniprot id: E4SDA0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS03010
gene id: 632348:CALKRO_RS03010
uniprot id: E4SEK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS12470
gene id: 632348:CALKRO_RS12470
uniprot id: E4SHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

632348:CALKRO RS01680
gene id: 632348:CALKRO_RS01680
uniprot id: E4SDU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01000
gene id: 632348:CALKRO_RS01000
uniprot id: E4SD53
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

632348:CALKRO RS05915
gene id: 632348:CALKRO_RS05915
uniprot id: E4SD18
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS05410
gene id: 632348:CALKRO_RS05410
uniprot id: E4SCK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

632348:CALKRO RS08145
gene id: 632348:CALKRO_RS08145
uniprot id: E4SFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

632348:CALKRO RS07355
gene id: 632348:CALKRO_RS07355
uniprot id: E4SC74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

632348:CALKRO RS09580
gene id: 632348:CALKRO_RS09580
uniprot id: E4SG67
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

632348:CALKRO RS05910
gene id: 632348:CALKRO_RS05910
uniprot id: E4SD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

632348:CALKRO RS05900
gene id: 632348:CALKRO_RS05900
uniprot id: E4SD15
names: Similarity
messages: Belongs to the peptidase M29 family.

632348:CALKRO RS08470
gene id: 632348:CALKRO_RS08470
uniprot id: E4SFK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05245
gene id: 632348:CALKRO_RS05245
uniprot id: E4SCH7
names: Similarity
messages: Belongs to the bacterial flagellin family.

632348:CALKRO RS01420
gene id: 632348:CALKRO_RS01420
uniprot id: E4SDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS03790
gene id: 632348:CALKRO_RS03790
uniprot id: E4SF04
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

632348:CALKRO RS08980
gene id: 632348:CALKRO_RS08980
uniprot id: E4SFV6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06210
gene id: 632348:CALKRO_RS06210
uniprot id: E4SBG1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS04845
gene id: 632348:CALKRO_RS04845
uniprot id: E4SDT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

632348:CALKRO RS07675
gene id: 632348:CALKRO_RS07675
uniprot id: E4SF48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04890
gene id: 632348:CALKRO_RS04890
uniprot id: E4SB67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

632348:CALKRO RS05850
gene id: 632348:CALKRO_RS05850
uniprot id: E4SD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

632348:CALKRO RS10065
gene id: 632348:CALKRO_RS10065
uniprot id: E4SGF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

632348:CALKRO RS12305
gene id: 632348:CALKRO_RS12305
uniprot id: E4SHM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

632348:CALKRO RS01015
gene id: 632348:CALKRO_RS01015
uniprot id: E4SD56
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

632348:CALKRO RS00595
gene id: 632348:CALKRO_RS00595
uniprot id: E4SCQ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

632348:CALKRO RS04980
gene id: 632348:CALKRO_RS04980
uniprot id: E4SB85
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

632348:CALKRO RS04550
gene id: 632348:CALKRO_RS04550
uniprot id: E4SDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

632348:CALKRO RS06255
gene id: 632348:CALKRO_RS06255
uniprot id: E4SBH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

632348:CALKRO RS12300
gene id: 632348:CALKRO_RS12300
uniprot id: E4SHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

632348:CALKRO RS11285
gene id: 632348:CALKRO_RS11285
uniprot id: E4SH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS00900
gene id: 632348:CALKRO_RS00900
uniprot id: E4SCW3
names: Similarity
messages: Belongs to the UPF0236 family.

632348:CALKRO RS04515
gene id: 632348:CALKRO_RS04515
uniprot id: E4SDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

632348:CALKRO RS10300
gene id: 632348:CALKRO_RS10300
uniprot id: E4SGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10210
gene id: 632348:CALKRO_RS10210
uniprot id: E4SGI5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

632348:CALKRO RS06615
gene id: 632348:CALKRO_RS06615
uniprot id: E4SBP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Monomer.

632348:CALKRO RS05025
gene id: 632348:CALKRO_RS05025
uniprot id: E4SB92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS00400
gene id: 632348:CALKRO_RS00400
uniprot id: E4SCE2
names: Similarity
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.

632348:CALKRO RS06115
gene id: 632348:CALKRO_RS06115
uniprot id: E4SBE2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

632348:CALKRO RS01450
gene id: 632348:CALKRO_RS01450
uniprot id: E4SDK7
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

632348:CALKRO RS10140
gene id: 632348:CALKRO_RS10140
uniprot id: E4SGH4
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

632348:CALKRO RS04005
gene id: 632348:CALKRO_RS04005
uniprot id: E4SB21
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS07055
gene id: 632348:CALKRO_RS07055
uniprot id: E4SBX7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

632348:CALKRO RS07150
gene id: 632348:CALKRO_RS07150
uniprot id: E4SBZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

632348:CALKRO RS10155
gene id: 632348:CALKRO_RS10155
uniprot id: E4SGH7
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

632348:CALKRO RS13030
gene id: 632348:CALKRO_RS13030
uniprot id: E4SI09
names: Similarity
messages: Belongs to the GerABKA family.

632348:CALKRO RS04925
gene id: 632348:CALKRO_RS04925
uniprot id: E4SB74
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

632348:CALKRO RS10815
gene id: 632348:CALKRO_RS10815
uniprot id: E4SGV4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

632348:CALKRO RS10165
gene id: 632348:CALKRO_RS10165
uniprot id: E4SGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS02355
gene id: 632348:CALKRO_RS02355
uniprot id: E4SE76
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

632348:CALKRO RS06590
gene id: 632348:CALKRO_RS06590
uniprot id: E4SBN7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

632348:CALKRO RS00040
gene id: 632348:CALKRO_RS00040
uniprot id: E4SC05
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

632348:CALKRO RS01300
gene id: 632348:CALKRO_RS01300
uniprot id: E4SDH9
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

632348:CALKRO RS04390
gene id: 632348:CALKRO_RS04390
uniprot id: E4SDE0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

632348:CALKRO RS01790
gene id: 632348:CALKRO_RS01790
uniprot id: E4SDW9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

632348:CALKRO RS08755
gene id: 632348:CALKRO_RS08755
uniprot id: E4SFR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS08655
gene id: 632348:CALKRO_RS08655
uniprot id: E4SFP1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

632348:CALKRO RS00730
gene id: 632348:CALKRO_RS00730
uniprot id: E4SCS9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

632348:CALKRO RS06245
gene id: 632348:CALKRO_RS06245
uniprot id: E4SBG8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

632348:CALKRO RS08745
gene id: 632348:CALKRO_RS08745
uniprot id: E4SFQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

632348:CALKRO RS09040
gene id: 632348:CALKRO_RS09040
uniprot id: E4SFW4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS02415
gene id: 632348:CALKRO_RS02415
uniprot id: E4SE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

632348:CALKRO RS02440
gene id: 632348:CALKRO_RS02440
uniprot id: E4SE93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

632348:CALKRO RS07550
gene id: 632348:CALKRO_RS07550
uniprot id: E4SF23
names: Similarity
messages: Belongs to the UPF0297 family.

632348:CALKRO RS09200
gene id: 632348:CALKRO_RS09200
uniprot id: E4SFZ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

632348:CALKRO RS07815
gene id: 632348:CALKRO_RS07815
uniprot id: E4SF75
names: Similarity
messages: Belongs to the UDPGP type 2 family.

632348:CALKRO RS09035
gene id: 632348:CALKRO_RS09035
uniprot id: E4SFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS06200
gene id: 632348:CALKRO_RS06200
uniprot id: E4SBF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

632348:CALKRO RS01670
gene id: 632348:CALKRO_RS01670
uniprot id: E4SDU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

632348:CALKRO RS04715
gene id: 632348:CALKRO_RS04715
uniprot id: E4SDR4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS08640
gene id: 632348:CALKRO_RS08640
uniprot id: E4SFN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

632348:CALKRO RS10565
gene id: 632348:CALKRO_RS10565
uniprot id: E4SGQ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS05155
gene id: 632348:CALKRO_RS05155
uniprot id: E4SBB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

632348:CALKRO RS12100
gene id: 632348:CALKRO_RS12100
uniprot id: E4SHJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

632348:CALKRO RS11140
gene id: 632348:CALKRO_RS11140
uniprot id: E4SH15
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

632348:CALKRO RS02345
gene id: 632348:CALKRO_RS02345
uniprot id: E4SE74
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

632348:CALKRO RS06770
gene id: 632348:CALKRO_RS06770
uniprot id: E4SBS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

632348:CALKRO RS01250
gene id: 632348:CALKRO_RS01250
uniprot id: E4SDA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

632348:CALKRO RS04655
gene id: 632348:CALKRO_RS04655
uniprot id: E4SDQ1
names: Similarity
messages: Belongs to the BMP lipoprotein family.

632348:CALKRO RS11615
gene id: 632348:CALKRO_RS11615
uniprot id: E4SHA0
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

632348:CALKRO RS01510
gene id: 632348:CALKRO_RS01510
uniprot id: E4SDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09625
gene id: 632348:CALKRO_RS09625
uniprot id: E4SG75
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

632348:CALKRO RS04070
gene id: 632348:CALKRO_RS04070
uniprot id: E4SB34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

632348:CALKRO RS02975
gene id: 632348:CALKRO_RS02975
uniprot id: E4SEJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

632348:CALKRO RS09595
gene id: 632348:CALKRO_RS09595
uniprot id: E4SG70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

632348:CALKRO RS11680
gene id: 632348:CALKRO_RS11680
uniprot id: E4SHB3
names: Similarity
messages: Belongs to the ComB family.

632348:CALKRO RS06750
gene id: 632348:CALKRO_RS06750
uniprot id: E4SBR6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

632348:CALKRO RS08505
gene id: 632348:CALKRO_RS08505
uniprot id: E4SFL0
names: Similarity
messages: Belongs to the asp23 family.

632348:CALKRO RS09920
gene id: 632348:CALKRO_RS09920
uniprot id: E4SGD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS03410
gene id: 632348:CALKRO_RS03410
uniprot id: E4SET2
names: Similarity
messages: Belongs to the peptidase A24 family.

632348:CALKRO RS06250
gene id: 632348:CALKRO_RS06250
uniprot id: E4SBG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

632348:CALKRO RS05925
gene id: 632348:CALKRO_RS05925
uniprot id: E4SD20
names: Similarity
messages: Belongs to the asparagine synthetase family.

632348:CALKRO RS04295
gene id: 632348:CALKRO_RS04295
uniprot id: E4SDC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

632348:CALKRO RS08645
gene id: 632348:CALKRO_RS08645
uniprot id: E4SFN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

632348:CALKRO RS10515
gene id: 632348:CALKRO_RS10515
uniprot id: E4SGP7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

632348:CALKRO RS08360
gene id: 632348:CALKRO_RS08360
uniprot id: E4SFI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

632348:CALKRO RS10845
gene id: 632348:CALKRO_RS10845
uniprot id: E4SGW1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

632348:CALKRO RS12975
gene id: 632348:CALKRO_RS12975
uniprot id: E4SHZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

632348:CALKRO RS06730
gene id: 632348:CALKRO_RS06730
uniprot id: E4SBR2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

632348:CALKRO RS12110
gene id: 632348:CALKRO_RS12110
uniprot id: E4SHJ6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS06815
gene id: 632348:CALKRO_RS06815
uniprot id: E4SBS8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

632348:CALKRO RS04560
gene id: 632348:CALKRO_RS04560
uniprot id: E4SDH4
names: Similarity
messages: Belongs to the CdaR family.

632348:CALKRO RS00620
gene id: 632348:CALKRO_RS00620
uniprot id: E4SCQ8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS04325
gene id: 632348:CALKRO_RS04325
uniprot id: E4SDD0
names: Similarity
messages: Belongs to the polysaccharide lyase 3 family.

632348:CALKRO RS09420
gene id: 632348:CALKRO_RS09420
uniprot id: E4SG40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

632348:CALKRO RS06235
gene id: 632348:CALKRO_RS06235
uniprot id: E4SBG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

632348:CALKRO RS01500
gene id: 632348:CALKRO_RS01500
uniprot id: E4SDL4
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

632348:CALKRO RS06205
gene id: 632348:CALKRO_RS06205
uniprot id: E4SBG0
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

632348:CALKRO RS10150
gene id: 632348:CALKRO_RS10150
uniprot id: E4SGH6
names: Similarity
messages: Belongs to the PGI/PMI family.

632348:CALKRO RS08220
gene id: 632348:CALKRO_RS08220
uniprot id: E4SFF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS03385
gene id: 632348:CALKRO_RS03385
uniprot id: E4SES7
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

632348:CALKRO RS08580
gene id: 632348:CALKRO_RS08580
uniprot id: E4SFM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

632348:CALKRO RS09440
gene id: 632348:CALKRO_RS09440
uniprot id: E4SG44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS07380
gene id: 632348:CALKRO_RS07380
uniprot id: E4SC79
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS10295
gene id: 632348:CALKRO_RS10295
uniprot id: E4SGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07255
gene id: 632348:CALKRO_RS07255
uniprot id: E4SC54
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

632348:CALKRO RS02970
gene id: 632348:CALKRO_RS02970
uniprot id: E4SEJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

632348:CALKRO RS07560
gene id: 632348:CALKRO_RS07560
uniprot id: E4SF25
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

632348:CALKRO RS07325
gene id: 632348:CALKRO_RS07325
uniprot id: E4SC68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

632348:CALKRO RS06620
gene id: 632348:CALKRO_RS06620
uniprot id: E4SBP3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

632348:CALKRO RS04205
gene id: 632348:CALKRO_RS04205
uniprot id: E4SDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

632348:CALKRO RS04670
gene id: 632348:CALKRO_RS04670
uniprot id: E4SDQ4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS07765
gene id: 632348:CALKRO_RS07765
uniprot id: E4SF65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

632348:CALKRO RS01255
gene id: 632348:CALKRO_RS01255
uniprot id: E4SDA4
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

632348:CALKRO RS09745
gene id: 632348:CALKRO_RS09745
uniprot id: E4SG96
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

632348:CALKRO RS11885
gene id: 632348:CALKRO_RS11885
uniprot id: E4SHF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06910
gene id: 632348:CALKRO_RS06910
uniprot id: E4SBU6
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS08485
gene id: 632348:CALKRO_RS08485
uniprot id: E4SFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

632348:CALKRO RS01355
gene id: 632348:CALKRO_RS01355
uniprot id: E4SDI9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS08635
gene id: 632348:CALKRO_RS08635
uniprot id: E4SFN7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

632348:CALKRO RS02660
gene id: 632348:CALKRO_RS02660
uniprot id: E4SED7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

632348:CALKRO RS00815
gene id: 632348:CALKRO_RS00815
uniprot id: E4SCU6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

632348:CALKRO RS10735
gene id: 632348:CALKRO_RS10735
uniprot id: E4SGT8
names: Similarity
messages: Belongs to the P(II) protein family.

632348:CALKRO RS00530
gene id: 632348:CALKRO_RS00530
uniprot id: E4SCG8
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS08570
gene id: 632348:CALKRO_RS08570
uniprot id: E4SFM3
names: Similarity
messages: Belongs to the CinA family.

632348:CALKRO RS03485
gene id: 632348:CALKRO_RS03485
uniprot id: E4SEU7
names: Similarity
messages: Belongs to the UPF0236 family.

632348:CALKRO RS08435
gene id: 632348:CALKRO_RS08435
uniprot id: E4SFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01240
gene id: 632348:CALKRO_RS01240
uniprot id: E4SDA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

632348:CALKRO RS11480
gene id: 632348:CALKRO_RS11480
uniprot id: E4SH77
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

632348:CALKRO RS06175
gene id: 632348:CALKRO_RS06175
uniprot id: E4SBF4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

632348:CALKRO RS01115
gene id: 632348:CALKRO_RS01115
uniprot id: E4SD76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS02965
gene id: 632348:CALKRO_RS02965
uniprot id: E4SEJ3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

632348:CALKRO RS06745
gene id: 632348:CALKRO_RS06745
uniprot id: E4SBR5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS12980
gene id: 632348:CALKRO_RS12980
uniprot id: E4SHZ9
names: Similarity
messages: Belongs to the alkaline phosphatase family.

632348:CALKRO RS02850
gene id: 632348:CALKRO_RS02850
uniprot id: E4SEH2
names: Similarity
messages: Belongs to the FGGY kinase family.

632348:CALKRO RS07145
gene id: 632348:CALKRO_RS07145
uniprot id: E4SBZ5
names: Similarity
messages: Belongs to the TlyA family.

632348:CALKRO RS04970
gene id: 632348:CALKRO_RS04970
uniprot id: E4SB83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

632348:CALKRO RS12760
gene id: 632348:CALKRO_RS12760
uniprot id: E4SHV5
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

632348:CALKRO RS04910
gene id: 632348:CALKRO_RS04910
uniprot id: E4SB71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

632348:CALKRO RS06140
gene id: 632348:CALKRO_RS06140
uniprot id: E4SBE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS02655
gene id: 632348:CALKRO_RS02655
uniprot id: E4SED6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

632348:CALKRO RS06150
gene id: 632348:CALKRO_RS06150
uniprot id: E4SBE9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

632348:CALKRO RS10975
gene id: 632348:CALKRO_RS10975
uniprot id: E4SGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

632348:CALKRO RS10505
gene id: 632348:CALKRO_RS10505
uniprot id: E4SGP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

632348:CALKRO RS10340
gene id: 632348:CALKRO_RS10340
uniprot id: E4SGL1
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS09840
gene id: 632348:CALKRO_RS09840
uniprot id: E4SGB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

632348:CALKRO RS06960
gene id: 632348:CALKRO_RS06960
uniprot id: E4SBV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

632348:CALKRO RS11790
gene id: 632348:CALKRO_RS11790
uniprot id: E4SHD4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS02320
gene id: 632348:CALKRO_RS02320
uniprot id: E4SE69
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

632348:CALKRO RS09305
gene id: 632348:CALKRO_RS09305
uniprot id: E4SG17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

632348:CALKRO RS04485
gene id: 632348:CALKRO_RS04485
uniprot id: E4SDF9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

632348:CALKRO RS11625
gene id: 632348:CALKRO_RS11625
uniprot id: E4SHA2
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

632348:CALKRO RS09860
gene id: 632348:CALKRO_RS09860
uniprot id: E4SGB8
names: Similarity
messages: Belongs to the UPF0047 family.

632348:CALKRO RS06420
gene id: 632348:CALKRO_RS06420
uniprot id: E4SBK3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

632348:CALKRO RS07950
gene id: 632348:CALKRO_RS07950
uniprot id: E4SFA1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

632348:CALKRO RS09260
gene id: 632348:CALKRO_RS09260
uniprot id: E4SG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

632348:CALKRO RS11130
gene id: 632348:CALKRO_RS11130
uniprot id: E4SH13
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

632348:CALKRO RS13025
gene id: 632348:CALKRO_RS13025
uniprot id: E4SI08
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

632348:CALKRO RS07605
gene id: 632348:CALKRO_RS07605
uniprot id: E4SF34
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

632348:CALKRO RS04705
gene id: 632348:CALKRO_RS04705
uniprot id: E4SDR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

632348:CALKRO RS07265
gene id: 632348:CALKRO_RS07265
uniprot id: E4SC56
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

632348:CALKRO RS08480
gene id: 632348:CALKRO_RS08480
uniprot id: E4SFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

632348:CALKRO RS07760
gene id: 632348:CALKRO_RS07760
uniprot id: E4SF64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

632348:CALKRO RS09680
gene id: 632348:CALKRO_RS09680
uniprot id: E4SG85
names: Similarity
messages: Belongs to the 5'-nucleotidase family.
messages: Belongs to the CapA family.

632348:CALKRO RS06945
gene id: 632348:CALKRO_RS06945
uniprot id: E4SBV3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

632348:CALKRO RS13075
gene id: 632348:CALKRO_RS13075
uniprot id: E4SE15
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

632348:CALKRO RS08245
gene id: 632348:CALKRO_RS08245
uniprot id: E4SFF9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

632348:CALKRO RS07630
gene id: 632348:CALKRO_RS07630
uniprot id: E4SF39
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

632348:CALKRO RS02075
gene id: 632348:CALKRO_RS02075
uniprot id: E4SE25
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS04975
gene id: 632348:CALKRO_RS04975
uniprot id: E4SB84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

632348:CALKRO RS10120
gene id: 632348:CALKRO_RS10120
uniprot id: E4SGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

632348:CALKRO RS06295
gene id: 632348:CALKRO_RS06295
uniprot id: E4SBH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

632348:CALKRO RS04855
gene id: 632348:CALKRO_RS04855
uniprot id: E4SDU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

632348:CALKRO RS10090
gene id: 632348:CALKRO_RS10090
uniprot id: E4SGG3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

632348:CALKRO RS09645
gene id: 632348:CALKRO_RS09645
uniprot id: E4SG79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS08325
gene id: 632348:CALKRO_RS08325
uniprot id: E4SFH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

632348:CALKRO RS10585
gene id: 632348:CALKRO_RS10585
uniprot id: E4SGR1
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS10500
gene id: 632348:CALKRO_RS10500
uniprot id: E4SGP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

632348:CALKRO RS00155
gene id: 632348:CALKRO_RS00155
uniprot id: E4SC26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

632348:CALKRO RS12530
gene id: 632348:CALKRO_RS12530
uniprot id: E4SHS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

632348:CALKRO RS03490
gene id: 632348:CALKRO_RS03490
uniprot id: E4SER5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

632348:CALKRO RS09070
gene id: 632348:CALKRO_RS09070
uniprot id: E4SFX0
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

632348:CALKRO RS03115
gene id: 632348:CALKRO_RS03115
uniprot id: E4SEM5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

632348:CALKRO RS07220
gene id: 632348:CALKRO_RS07220
uniprot id: E4SC47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

632348:CALKRO RS01490
gene id: 632348:CALKRO_RS01490
uniprot id: E4SDL2
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

632348:CALKRO RS05430
gene id: 632348:CALKRO_RS05430
uniprot id: E4SCL0
names: Subcellular Location Annotation
messages: Cell membrane

632348:CALKRO RS05205
gene id: 632348:CALKRO_RS05205
uniprot id: E4SBC1
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

632348:CALKRO RS10460
gene id: 632348:CALKRO_RS10460
uniprot id: E4SGN6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

632348:CALKRO RS04640
gene id: 632348:CALKRO_RS04640
uniprot id: E4SDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

632348:CALKRO RS06610
gene id: 632348:CALKRO_RS06610
uniprot id: E4SBP1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

632348:CALKRO RS06880
gene id: 632348:CALKRO_RS06880
uniprot id: E4SBU0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

632348:CALKRO RS08015
gene id: 632348:CALKRO_RS08015
uniprot id: E4SFB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

632348:CALKRO RS10100
gene id: 632348:CALKRO_RS10100
uniprot id: E4SGG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS07200
gene id: 632348:CALKRO_RS07200
uniprot id: E4SC43
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

632348:CALKRO RS12220
gene id: 632348:CALKRO_RS12220
uniprot id: E4SHL4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.

632348:CALKRO RS08285
gene id: 632348:CALKRO_RS08285
uniprot id: E4SFG7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

632348:CALKRO RS11645
gene id: 632348:CALKRO_RS11645
uniprot id: E4SHA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

632348:CALKRO RS02985
gene id: 632348:CALKRO_RS02985
uniprot id: E4SEJ7
names: Similarity
messages: Belongs to the P(II) protein family.

632348:CALKRO RS11605
gene id: 632348:CALKRO_RS11605
uniprot id: E4SH98
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

632348:CALKRO RS09145
gene id: 632348:CALKRO_RS09145
uniprot id: E4SFY5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

632348:CALKRO RS05885
gene id: 632348:CALKRO_RS05885
uniprot id: E4SD12
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS02525
gene id: 632348:CALKRO_RS02525
uniprot id: E4SEB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

632348:CALKRO RS11400
gene id: 632348:CALKRO_RS11400
uniprot id: E4SH61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

632348:CALKRO RS03590
gene id: 632348:CALKRO_RS03590
uniprot id: E4SEW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

632348:CALKRO RS08940
gene id: 632348:CALKRO_RS08940
uniprot id: E4SFU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

632348:CALKRO RS07705
gene id: 632348:CALKRO_RS07705
uniprot id: E4SF54
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

632348:CALKRO RS02070
gene id: 632348:CALKRO_RS02070
uniprot id: E4SE24
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

632348:CALKRO RS10425
gene id: 632348:CALKRO_RS10425
uniprot id: E4SGM8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS06855
gene id: 632348:CALKRO_RS06855
uniprot id: E4SBT5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

632348:CALKRO RS03005
gene id: 632348:CALKRO_RS03005
uniprot id: E4SEK2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

632348:CALKRO RS05085
gene id: 632348:CALKRO_RS05085
uniprot id: E4SB99
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06585
gene id: 632348:CALKRO_RS06585
uniprot id: E4SBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS12025
gene id: 632348:CALKRO_RS12025
uniprot id: E4SHH9
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

632348:CALKRO RS08780
gene id: 632348:CALKRO_RS08780
uniprot id: E4SFR5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

632348:CALKRO RS12755
gene id: 632348:CALKRO_RS12755
uniprot id: E4SHV4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

632348:CALKRO RS07045
gene id: 632348:CALKRO_RS07045
uniprot id: E4SBX5
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06365
gene id: 632348:CALKRO_RS06365
uniprot id: E4SBJ2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS01515
gene id: 632348:CALKRO_RS01515
uniprot id: E4SDL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS02675
gene id: 632348:CALKRO_RS02675
uniprot id: E4SEE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

632348:CALKRO RS02220
gene id: 632348:CALKRO_RS02220
uniprot id: E4SE52
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

632348:CALKRO RS01425
gene id: 632348:CALKRO_RS01425
uniprot id: E4SDK3
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

632348:CALKRO RS05985
gene id: 632348:CALKRO_RS05985
uniprot id: E4SD29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

632348:CALKRO RS00545
gene id: 632348:CALKRO_RS00545
uniprot id: E4SCH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS02365
gene id: 632348:CALKRO_RS02365
uniprot id: E4SE78
names: Subcellular Location Annotation
messages: Cytoplasm

632348:CALKRO RS10040
gene id: 632348:CALKRO_RS10040
uniprot id: E4SGF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

632348:CALKRO RS03600
gene id: 632348:CALKRO_RS03600
uniprot id: E4SEW8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

632348:CALKRO RS08975
gene id: 632348:CALKRO_RS08975
uniprot id: E4SFV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08280
gene id: 632348:CALKRO_RS08280
uniprot id: E4SFG6
names: Similarity
messages: Belongs to the ribF family.

632348:CALKRO RS00570
gene id: 632348:CALKRO_RS00570
uniprot id: E4SCP8
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

632348:CALKRO RS02385
gene id: 632348:CALKRO_RS02385
uniprot id: E4SE82
names: Similarity
messages: Belongs to the FlgD family.

632348:CALKRO RS08475
gene id: 632348:CALKRO_RS08475
uniprot id: E4SFK4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

632348:CALKRO RS12840
gene id: 632348:CALKRO_RS12840
uniprot id: E4SHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

632348:CALKRO RS12405
gene id: 632348:CALKRO_RS12405
uniprot id: E4SHP6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS11180
gene id: 632348:CALKRO_RS11180
uniprot id: E4SH23
names: Similarity
messages: Belongs to the phosphopentomutase family.

632348:CALKRO RS02100
gene id: 632348:CALKRO_RS02100
uniprot id: E4SE30
names: Similarity
messages: Belongs to the ribulokinase family.

632348:CALKRO RS10170
gene id: 632348:CALKRO_RS10170
uniprot id: E4SGI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05175
gene id: 632348:CALKRO_RS05175
uniprot id: E4SBB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

632348:CALKRO RS06155
gene id: 632348:CALKRO_RS06155
uniprot id: E4SBF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

632348:CALKRO RS12065
gene id: 632348:CALKRO_RS12065
uniprot id: E4SHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10245
gene id: 632348:CALKRO_RS10245
uniprot id: E4SGJ2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS12820
gene id: 632348:CALKRO_RS12820
uniprot id: E4SHW6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

632348:CALKRO RS04525
gene id: 632348:CALKRO_RS04525
uniprot id: E4SDG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

632348:CALKRO RS08910
gene id: 632348:CALKRO_RS08910
uniprot id: E4SFU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS12210
gene id: 632348:CALKRO_RS12210
uniprot id: E4SHL2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

632348:CALKRO RS07925
gene id: 632348:CALKRO_RS07925
uniprot id: E4SF96
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

632348:CALKRO RS08195
gene id: 632348:CALKRO_RS08195
uniprot id: E4SFE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

632348:CALKRO RS07590
gene id: 632348:CALKRO_RS07590
uniprot id: E4SF31
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

632348:CALKRO RS11950
gene id: 632348:CALKRO_RS11950
uniprot id: E4SHG4
names: Similarity
messages: Belongs to the DHPS family.

632348:CALKRO RS02395
gene id: 632348:CALKRO_RS02395
uniprot id: E4SE84
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

632348:CALKRO RS10560
gene id: 632348:CALKRO_RS10560
uniprot id: E4SGQ6
names: Similarity
messages: Belongs to the UPF0145 family.

632348:CALKRO RS08035
gene id: 632348:CALKRO_RS08035
uniprot id: E4SFB7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

632348:CALKRO RS01810
gene id: 632348:CALKRO_RS01810
uniprot id: E4SDX3
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS10060
gene id: 632348:CALKRO_RS10060
uniprot id: E4SGF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

632348:CALKRO RS12205
gene id: 632348:CALKRO_RS12205
uniprot id: E4SHL1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

632348:CALKRO RS06110
gene id: 632348:CALKRO_RS06110
uniprot id: E4SBE1
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

632348:CALKRO RS13090
gene id: 632348:CALKRO_RS13090
uniprot id: E4SER7
names: Similarity
messages: Belongs to the RNase H family.

632348:CALKRO RS12990
gene id: 632348:CALKRO_RS12990
uniprot id: E4SI01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

632348:CALKRO RS01650
gene id: 632348:CALKRO_RS01650
uniprot id: E4SDU2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

632348:CALKRO RS06900
gene id: 632348:CALKRO_RS06900
uniprot id: E4SBU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

632348:CALKRO RS11955
gene id: 632348:CALKRO_RS11955
uniprot id: E4SHG5
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

632348:CALKRO RS05975
gene id: 632348:CALKRO_RS05975
uniprot id: E4SD27
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

632348:CALKRO RS04080
gene id: 632348:CALKRO_RS04080
uniprot id: E4SB37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

632348:CALKRO RS08180
gene id: 632348:CALKRO_RS08180
uniprot id: E4SFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

632348:CALKRO RS07085
gene id: 632348:CALKRO_RS07085
uniprot id: E4SBY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

632348:CALKRO RS12480
gene id: 632348:CALKRO_RS12480
uniprot id: E4SHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

632348:CALKRO RS02160
gene id: 632348:CALKRO_RS02160
uniprot id: E4SE42
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS12035
gene id: 632348:CALKRO_RS12035
uniprot id: E4SHI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

632348:CALKRO RS06380
gene id: 632348:CALKRO_RS06380
uniprot id: E4SBJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10495
gene id: 632348:CALKRO_RS10495
uniprot id: E4SGP3
names: Similarity
messages: Belongs to the UPF0758 family.

632348:CALKRO RS08885
gene id: 632348:CALKRO_RS08885
uniprot id: E4SFT7
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05965
gene id: 632348:CALKRO_RS05965
uniprot id: E4SD25
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

632348:CALKRO RS11355
gene id: 632348:CALKRO_RS11355
uniprot id: E4SH54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

632348:CALKRO RS06105
gene id: 632348:CALKRO_RS06105
uniprot id: E4SBE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

632348:CALKRO RS04765
gene id: 632348:CALKRO_RS04765
uniprot id: E4SDS4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05035
gene id: 632348:CALKRO_RS05035
uniprot id: E4SB94
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

632348:CALKRO RS01660
gene id: 632348:CALKRO_RS01660
uniprot id: E4SDU4
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

632348:CALKRO RS06575
gene id: 632348:CALKRO_RS06575
uniprot id: E4SBN4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS07995
gene id: 632348:CALKRO_RS07995
uniprot id: E4SFA9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

632348:CALKRO RS06375
gene id: 632348:CALKRO_RS06375
uniprot id: E4SBJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

632348:CALKRO RS02260
gene id: 632348:CALKRO_RS02260
uniprot id: E4SE57
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

632348:CALKRO RS08115
gene id: 632348:CALKRO_RS08115
uniprot id: E4SFD3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

632348:CALKRO RS06510
gene id: 632348:CALKRO_RS06510
uniprot id: E4SBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

632348:CALKRO RS05030
gene id: 632348:CALKRO_RS05030
uniprot id: E4SB93
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

632348:CALKRO RS10945
gene id: 632348:CALKRO_RS10945
uniprot id: E4SGX9
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

632348:CALKRO RS09760
gene id: 632348:CALKRO_RS09760
uniprot id: E4SG99
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

632348:CALKRO RS00950
gene id: 632348:CALKRO_RS00950
uniprot id: E4SD44
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06460
gene id: 632348:CALKRO_RS06460
uniprot id: E4SBL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

632348:CALKRO RS07435
gene id: 632348:CALKRO_RS07435
uniprot id: E4SC90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm

632348:CALKRO RS08385
gene id: 632348:CALKRO_RS08385
uniprot id: E4SFI7
names: Similarity
messages: Belongs to the RemA family.

632348:CALKRO RS04045
gene id: 632348:CALKRO_RS04045
uniprot id: E4SB29
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

632348:CALKRO RS11060
gene id: 632348:CALKRO_RS11060
uniprot id: E4SH01
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

632348:CALKRO RS12395
gene id: 632348:CALKRO_RS12395
uniprot id: E4SHP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS06170
gene id: 632348:CALKRO_RS06170
uniprot id: E4SBF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

632348:CALKRO RS10965
gene id: 632348:CALKRO_RS10965
uniprot id: E4SGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

632348:CALKRO RS04185
gene id: 632348:CALKRO_RS04185
uniprot id: E4SB57
names: Similarity
messages: Belongs to the GSP E family.

632348:CALKRO RS05570
gene id: 632348:CALKRO_RS05570
uniprot id: E4SCN8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

632348:CALKRO RS09720
gene id: 632348:CALKRO_RS09720
uniprot id: E4SG91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

632348:CALKRO RS04030
gene id: 632348:CALKRO_RS04030
uniprot id: E4SB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07280
gene id: 632348:CALKRO_RS07280
uniprot id: E4SC59
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

632348:CALKRO RS04840
gene id: 632348:CALKRO_RS04840
uniprot id: E4SDT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

632348:CALKRO RS02735
gene id: 632348:CALKRO_RS02735
uniprot id: E4SEF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08935
gene id: 632348:CALKRO_RS08935
uniprot id: E4SFU7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

632348:CALKRO RS12510
gene id: 632348:CALKRO_RS12510
uniprot id: E4SHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

632348:CALKRO RS07285
gene id: 632348:CALKRO_RS07285
uniprot id: E4SC60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

632348:CALKRO RS03125
gene id: 632348:CALKRO_RS03125
uniprot id: E4SEM7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

632348:CALKRO RS06630
gene id: 632348:CALKRO_RS06630
uniprot id: E4SBP5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

632348:CALKRO RS02550
gene id: 632348:CALKRO_RS02550
uniprot id: E4SEB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS12015
gene id: 632348:CALKRO_RS12015
uniprot id: E4SHH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
messages: Homodimer.

632348:CALKRO RS10995
gene id: 632348:CALKRO_RS10995
uniprot id: E4SGY9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

632348:CALKRO RS04700
gene id: 632348:CALKRO_RS04700
uniprot id: E4SDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

632348:CALKRO RS09165
gene id: 632348:CALKRO_RS09165
uniprot id: E4SFY9
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00240
gene id: 632348:CALKRO_RS00240
uniprot id: E4SCB1
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

632348:CALKRO RS09290
gene id: 632348:CALKRO_RS09290
uniprot id: E4SG14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

632348:CALKRO RS06810
gene id: 632348:CALKRO_RS06810
uniprot id: E4SBS7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

632348:CALKRO RS06625
gene id: 632348:CALKRO_RS06625
uniprot id: E4SBP4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

632348:CALKRO RS07370
gene id: 632348:CALKRO_RS07370
uniprot id: E4SC77
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

632348:CALKRO RS04075
gene id: 632348:CALKRO_RS04075
uniprot id: E4SB36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

632348:CALKRO RS11020
gene id: 632348:CALKRO_RS11020
uniprot id: E4SGZ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

632348:CALKRO RS03050
gene id: 632348:CALKRO_RS03050
uniprot id: E4SEL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04685
gene id: 632348:CALKRO_RS04685
uniprot id: E4SDQ7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

632348:CALKRO RS12740
gene id: 632348:CALKRO_RS12740
uniprot id: E4SHV1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

632348:CALKRO RS11160
gene id: 632348:CALKRO_RS11160
uniprot id: E4SH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09450
gene id: 632348:CALKRO_RS09450
uniprot id: E4SG46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

632348:CALKRO RS08610
gene id: 632348:CALKRO_RS08610
uniprot id: E4SFN2
names: Similarity
messages: Belongs to the UPF0102 family.

632348:CALKRO RS06440
gene id: 632348:CALKRO_RS06440
uniprot id: E4SBK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

632348:CALKRO RS01415
gene id: 632348:CALKRO_RS01415
uniprot id: E4SDK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10275
gene id: 632348:CALKRO_RS10275
uniprot id: E4SGJ8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS00020
gene id: 632348:CALKRO_RS00020
uniprot id: E4SC00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

632348:CALKRO RS08260
gene id: 632348:CALKRO_RS08260
uniprot id: E4SFG2
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

632348:CALKRO RS03725
gene id: 632348:CALKRO_RS03725
uniprot id: E4SEZ1
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

632348:CALKRO RS06760
gene id: 632348:CALKRO_RS06760
uniprot id: E4SBR8
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

632348:CALKRO RS07405
gene id: 632348:CALKRO_RS07405
uniprot id: E4SC84
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

632348:CALKRO RS05450
gene id: 632348:CALKRO_RS05450
uniprot id: E4SCL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

632348:CALKRO RS09215
gene id: 632348:CALKRO_RS09215
uniprot id: E4SFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08010
gene id: 632348:CALKRO_RS08010
uniprot id: E4SFB2
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

632348:CALKRO RS10115
gene id: 632348:CALKRO_RS10115
uniprot id: E4SGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

632348:CALKRO RS09705
gene id: 632348:CALKRO_RS09705
uniprot id: E4SG88
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

632348:CALKRO RS08370
gene id: 632348:CALKRO_RS08370
uniprot id: E4SFI4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS10010
gene id: 632348:CALKRO_RS10010
uniprot id: E4SGE7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

632348:CALKRO RS12010
gene id: 632348:CALKRO_RS12010
uniprot id: E4SHH6
names: Similarity
messages: Belongs to the RutC family.

632348:CALKRO RS02940
gene id: 632348:CALKRO_RS02940
uniprot id: E4SEI8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

632348:CALKRO RS11475
gene id: 632348:CALKRO_RS11475
uniprot id: E4SH76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Cell membrane
messages: Probably a homodimer.

632348:CALKRO RS05805
gene id: 632348:CALKRO_RS05805
uniprot id: E4SCZ7
names: Similarity
messages: Belongs to the Fur family.

632348:CALKRO RS02995
gene id: 632348:CALKRO_RS02995
uniprot id: E4SEJ9
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

632348:CALKRO RS10235
gene id: 632348:CALKRO_RS10235
uniprot id: E4SGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01165
gene id: 632348:CALKRO_RS01165
uniprot id: E4SD86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

632348:CALKRO RS06530
gene id: 632348:CALKRO_RS06530
uniprot id: E4SBM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

632348:CALKRO RS03480
gene id: 632348:CALKRO_RS03480
uniprot id: E4SEU6
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

632348:CALKRO RS07080
gene id: 632348:CALKRO_RS07080
uniprot id: E4SBY2
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

632348:CALKRO RS04465
gene id: 632348:CALKRO_RS04465
uniprot id: E4SDF5
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05300
gene id: 632348:CALKRO_RS05300
uniprot id: E4SCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

632348:CALKRO RS06415
gene id: 632348:CALKRO_RS06415
uniprot id: E4SBK2
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS01185
gene id: 632348:CALKRO_RS01185
uniprot id: E4SD90
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS04540
gene id: 632348:CALKRO_RS04540
uniprot id: E4SDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

632348:CALKRO RS05995
gene id: 632348:CALKRO_RS05995
uniprot id: E4SD31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

632348:CALKRO RS10330
gene id: 632348:CALKRO_RS10330
uniprot id: E4SGK9
names: Similarity
messages: Belongs to the UPF0175 family.

632348:CALKRO RS04905
gene id: 632348:CALKRO_RS04905
uniprot id: E4SB70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

632348:CALKRO RS12750
gene id: 632348:CALKRO_RS12750
uniprot id: E4SHV3
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

632348:CALKRO RS03750
gene id: 632348:CALKRO_RS03750
uniprot id: E4SEZ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS00740
gene id: 632348:CALKRO_RS00740
uniprot id: E4SCT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

632348:CALKRO RS01770
gene id: 632348:CALKRO_RS01770
uniprot id: E4SDW5
names: Similarity
messages: Belongs to the UPF0251 family.

632348:CALKRO RS02960
gene id: 632348:CALKRO_RS02960
uniprot id: E4SEJ2
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

632348:CALKRO RS12930
gene id: 632348:CALKRO_RS12930
uniprot id: E4SHY9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

632348:CALKRO RS08095
gene id: 632348:CALKRO_RS08095
uniprot id: E4SFC9
names: Similarity
messages: Belongs to the HypD family.

632348:CALKRO RS02925
gene id: 632348:CALKRO_RS02925
uniprot id: E4SEI5
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

632348:CALKRO RS07345
gene id: 632348:CALKRO_RS07345
uniprot id: E4SC72
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS05185
gene id: 632348:CALKRO_RS05185
uniprot id: E4SBB9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06360
gene id: 632348:CALKRO_RS06360
uniprot id: E4SBJ1
names: Similarity
messages: Belongs to the HypE family.

632348:CALKRO RS09090
gene id: 632348:CALKRO_RS09090
uniprot id: E4SFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05870
gene id: 632348:CALKRO_RS05870
uniprot id: E4SD09
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

632348:CALKRO RS05170
gene id: 632348:CALKRO_RS05170
uniprot id: E4SBB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09750
gene id: 632348:CALKRO_RS09750
uniprot id: E4SG97
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

632348:CALKRO RS05255
gene id: 632348:CALKRO_RS05255
uniprot id: E4SCH9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

632348:CALKRO RS06485
gene id: 632348:CALKRO_RS06485
uniprot id: E4SBL6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

632348:CALKRO RS06675
gene id: 632348:CALKRO_RS06675
uniprot id: E4SBQ2
names: Similarity
messages: Belongs to the leucine-binding protein family.

632348:CALKRO RS11370
gene id: 632348:CALKRO_RS11370
uniprot id: E4SH57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

632348:CALKRO RS10830
gene id: 632348:CALKRO_RS10830
uniprot id: E4SGV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

632348:CALKRO RS06755
gene id: 632348:CALKRO_RS06755
uniprot id: E4SBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

632348:CALKRO RS10530
gene id: 632348:CALKRO_RS10530
uniprot id: E4SGQ0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

632348:CALKRO RS01945
gene id: 632348:CALKRO_RS01945
uniprot id: E4SE01
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06495
gene id: 632348:CALKRO_RS06495
uniprot id: E4SBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

632348:CALKRO RS08555
gene id: 632348:CALKRO_RS08555
uniprot id: E4SFM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

632348:CALKRO RS09540
gene id: 632348:CALKRO_RS09540
uniprot id: E4SG64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS06525
gene id: 632348:CALKRO_RS06525
uniprot id: E4SBM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

632348:CALKRO RS05545
gene id: 632348:CALKRO_RS05545
uniprot id: E4SCN2
names: Similarity
messages: Belongs to the thioredoxin family.

632348:CALKRO RS05920
gene id: 632348:CALKRO_RS05920
uniprot id: E4SD19
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

632348:CALKRO RS09470
gene id: 632348:CALKRO_RS09470
uniprot id: E4SG50
names: Similarity
messages: Belongs to the transpeptidase family.

632348:CALKRO RS00080
gene id: 632348:CALKRO_RS00080
uniprot id: E4SC13
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

632348:CALKRO RS03840
gene id: 632348:CALKRO_RS03840
uniprot id: E4SF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07880
gene id: 632348:CALKRO_RS07880
uniprot id: E4SF89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS02885
gene id: 632348:CALKRO_RS02885
uniprot id: E4SEH8
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00210
gene id: 632348:CALKRO_RS00210
uniprot id: E4SCA5
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS05740
gene id: 632348:CALKRO_RS05740
uniprot id: E4SCY5
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00795
gene id: 632348:CALKRO_RS00795
uniprot id: E4SCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07300
gene id: 632348:CALKRO_RS07300
uniprot id: E4SC63
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

632348:CALKRO RS01010
gene id: 632348:CALKRO_RS01010
uniprot id: E4SD55
names: Similarity
messages: Belongs to the HepT RNase toxin family.

632348:CALKRO RS04160
gene id: 632348:CALKRO_RS04160
uniprot id: E4SB53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

632348:CALKRO RS06100
gene id: 632348:CALKRO_RS06100
uniprot id: E4SBD9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

632348:CALKRO RS05530
gene id: 632348:CALKRO_RS05530
uniprot id: E4SCM9
names: Similarity
messages: Belongs to the EamA transporter family.

632348:CALKRO RS06740
gene id: 632348:CALKRO_RS06740
uniprot id: E4SBR4
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

632348:CALKRO RS03145
gene id: 632348:CALKRO_RS03145
uniprot id: E4SEN1
names: Similarity
messages: Belongs to the glutamate synthase family.

632348:CALKRO RS10695
gene id: 632348:CALKRO_RS10695
uniprot id: E4SGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08650
gene id: 632348:CALKRO_RS08650
uniprot id: E4SFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

632348:CALKRO RS07400
gene id: 632348:CALKRO_RS07400
uniprot id: E4SC83
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

632348:CALKRO RS05970
gene id: 632348:CALKRO_RS05970
uniprot id: E4SD26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

632348:CALKRO RS07385
gene id: 632348:CALKRO_RS07385
uniprot id: E4SC80
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00440
gene id: 632348:CALKRO_RS00440
uniprot id: E4SCF0
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

632348:CALKRO RS00335
gene id: 632348:CALKRO_RS00335
uniprot id: E4SCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS06665
gene id: 632348:CALKRO_RS06665
uniprot id: E4SBQ0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

632348:CALKRO RS07330
gene id: 632348:CALKRO_RS07330
uniprot id: E4SC69
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

632348:CALKRO RS07490
gene id: 632348:CALKRO_RS07490
uniprot id: E4SCA1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

632348:CALKRO RS02280
gene id: 632348:CALKRO_RS02280
uniprot id: E4SE61
names: Similarity
messages: Belongs to the Fur family.

632348:CALKRO RS03795
gene id: 632348:CALKRO_RS03795
uniprot id: E4SF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04015
gene id: 632348:CALKRO_RS04015
uniprot id: E4SB23
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

632348:CALKRO RS05120
gene id: 632348:CALKRO_RS05120
uniprot id: E4SBA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

632348:CALKRO RS08920
gene id: 632348:CALKRO_RS08920
uniprot id: E4SFU4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS09295
gene id: 632348:CALKRO_RS09295
uniprot id: E4SG15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

632348:CALKRO RS04850
gene id: 632348:CALKRO_RS04850
uniprot id: E4SDU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

632348:CALKRO RS02145
gene id: 632348:CALKRO_RS02145
uniprot id: E4SE39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

632348:CALKRO RS05160
gene id: 632348:CALKRO_RS05160
uniprot id: E4SBB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

632348:CALKRO RS06040
gene id: 632348:CALKRO_RS06040
uniprot id: E4SBD3
names: Similarity
messages: Belongs to the peptidase S16 family.

632348:CALKRO RS09585
gene id: 632348:CALKRO_RS09585
uniprot id: E4SG68
names: Subcellular Location Annotation
messages: Cytoplasm

632348:CALKRO RS08560
gene id: 632348:CALKRO_RS08560
uniprot id: E4SFM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

632348:CALKRO RS09050
gene id: 632348:CALKRO_RS09050
uniprot id: E4SFW6
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS13040
gene id: 632348:CALKRO_RS13040
uniprot id: E4SI11
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

632348:CALKRO RS02005
gene id: 632348:CALKRO_RS02005
uniprot id: E4SE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS11465
gene id: 632348:CALKRO_RS11465
uniprot id: E4SH74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

632348:CALKRO RS06025
gene id: 632348:CALKRO_RS06025
uniprot id: E4SBD0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

632348:CALKRO RS11070
gene id: 632348:CALKRO_RS11070
uniprot id: E4SH03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

632348:CALKRO RS06500
gene id: 632348:CALKRO_RS06500
uniprot id: E4SBL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

632348:CALKRO RS04490
gene id: 632348:CALKRO_RS04490
uniprot id: E4SDG0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

632348:CALKRO RS09710
gene id: 632348:CALKRO_RS09710
uniprot id: E4SG89
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

632348:CALKRO RS12845
gene id: 632348:CALKRO_RS12845
uniprot id: E4SHX1
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

632348:CALKRO RS09025
gene id: 632348:CALKRO_RS09025
uniprot id: E4SFW1
names: Similarity
messages: Belongs to the UPF0236 family.

632348:CALKRO RS10750
gene id: 632348:CALKRO_RS10750
uniprot id: E4SGU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04965
gene id: 632348:CALKRO_RS04965
uniprot id: E4SB82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

632348:CALKRO RS07180
gene id: 632348:CALKRO_RS07180
uniprot id: E4SC39
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

632348:CALKRO RS06915
gene id: 632348:CALKRO_RS06915
uniprot id: E4SBU7
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS10700
gene id: 632348:CALKRO_RS10700
uniprot id: E4SGT1
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

632348:CALKRO RS02495
gene id: 632348:CALKRO_RS02495
uniprot id: E4SEA4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

632348:CALKRO RS08125
gene id: 632348:CALKRO_RS08125
uniprot id: E4SFD5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Belongs to the complex I 49 kDa subunit family.

632348:CALKRO RS04650
gene id: 632348:CALKRO_RS04650
uniprot id: E4SDQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

632348:CALKRO RS10520
gene id: 632348:CALKRO_RS10520
uniprot id: E4SGP8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

632348:CALKRO RS06580
gene id: 632348:CALKRO_RS06580
uniprot id: E4SBN5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

632348:CALKRO RS09185
gene id: 632348:CALKRO_RS09185
uniprot id: E4SFZ3
names: Function
messages: May be involved in the biosynthesis of molybdopterin.

632348:CALKRO RS07420
gene id: 632348:CALKRO_RS07420
uniprot id: E4SC87
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

632348:CALKRO RS11100
gene id: 632348:CALKRO_RS11100
uniprot id: E4SH09
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

632348:CALKRO RS09125
gene id: 632348:CALKRO_RS09125
uniprot id: E4SFY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

632348:CALKRO RS04985
gene id: 632348:CALKRO_RS04985
uniprot id: E4SB86
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

632348:CALKRO RS10450
gene id: 632348:CALKRO_RS10450
uniprot id: E4SGN3
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

632348:CALKRO RS02805
gene id: 632348:CALKRO_RS02805
uniprot id: E4SEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07480
gene id: 632348:CALKRO_RS07480
uniprot id: E4SC99
names: Similarity
messages: Belongs to the asp23 family.

632348:CALKRO RS07785
gene id: 632348:CALKRO_RS07785
uniprot id: E4SF69
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

632348:CALKRO RS03135
gene id: 632348:CALKRO_RS03135
uniprot id: E4SEM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS02225
gene id: 632348:CALKRO_RS02225
uniprot id: E4SE53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

632348:CALKRO RS05150
gene id: 632348:CALKRO_RS05150
uniprot id: E4SBB2
names: Similarity
messages: Belongs to the TrpF family.

632348:CALKRO RS00385
gene id: 632348:CALKRO_RS00385
uniprot id: E4SCD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS05710
gene id: 632348:CALKRO_RS05710
uniprot id: E4SCY0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

632348:CALKRO RS04445
gene id: 632348:CALKRO_RS04445
uniprot id: E4SDF1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS05230
gene id: 632348:CALKRO_RS05230
uniprot id: E4SBC6
names: Similarity
messages: Belongs to the FlgM family.

632348:CALKRO RS10840
gene id: 632348:CALKRO_RS10840
uniprot id: E4SGW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

632348:CALKRO RS08170
gene id: 632348:CALKRO_RS08170
uniprot id: E4SFE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

632348:CALKRO RS07860
gene id: 632348:CALKRO_RS07860
uniprot id: E4SF85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

632348:CALKRO RS01815
gene id: 632348:CALKRO_RS01815
uniprot id: E4SDX4
names: Similarity
messages: Belongs to the CpsD/CapB family.

632348:CALKRO RS01030
gene id: 632348:CALKRO_RS01030
uniprot id: E4SD59
names: Similarity
messages: Belongs to the peptidase S41A family.

632348:CALKRO RS08455
gene id: 632348:CALKRO_RS08455
uniprot id: E4SFK0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

632348:CALKRO RS10740
gene id: 632348:CALKRO_RS10740
uniprot id: E4SGT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

632348:CALKRO RS12810
gene id: 632348:CALKRO_RS12810
uniprot id: E4SHW4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS08135
gene id: 632348:CALKRO_RS08135
uniprot id: E4SFD7
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

632348:CALKRO RS03695
gene id: 632348:CALKRO_RS03695
uniprot id: E4SEY5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

632348:CALKRO RS01200
gene id: 632348:CALKRO_RS01200
uniprot id: E4SD93
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

632348:CALKRO RS04435
gene id: 632348:CALKRO_RS04435
uniprot id: E4SDE9
names: Similarity
messages: Belongs to the CtsR family.

632348:CALKRO RS02620
gene id: 632348:CALKRO_RS02620
uniprot id: E4SEC9
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

632348:CALKRO RS08630
gene id: 632348:CALKRO_RS08630
uniprot id: E4SFN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

632348:CALKRO RS02810
gene id: 632348:CALKRO_RS02810
uniprot id: E4SEG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09410
gene id: 632348:CALKRO_RS09410
uniprot id: E4SG38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

632348:CALKRO RS08300
gene id: 632348:CALKRO_RS08300
uniprot id: E4SFH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

632348:CALKRO RS11505
gene id: 632348:CALKRO_RS11505
uniprot id: E4SH82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09380
gene id: 632348:CALKRO_RS09380
uniprot id: E4SG32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS09660
gene id: 632348:CALKRO_RS09660
uniprot id: E4SG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08175
gene id: 632348:CALKRO_RS08175
uniprot id: E4SFE5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

632348:CALKRO RS04835
gene id: 632348:CALKRO_RS04835
uniprot id: E4SDT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

632348:CALKRO RS00800
gene id: 632348:CALKRO_RS00800
uniprot id: E4SCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04270
gene id: 632348:CALKRO_RS04270
uniprot id: E4SDB8
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

632348:CALKRO RS10555
gene id: 632348:CALKRO_RS10555
uniprot id: E4SGQ5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS10510
gene id: 632348:CALKRO_RS10510
uniprot id: E4SGP6
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

632348:CALKRO RS13020
gene id: 632348:CALKRO_RS13020
uniprot id: E4SI07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

632348:CALKRO RS06180
gene id: 632348:CALKRO_RS06180
uniprot id: E4SBF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

632348:CALKRO RS00425
gene id: 632348:CALKRO_RS00425
uniprot id: E4SCE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10315
gene id: 632348:CALKRO_RS10315
uniprot id: E4SGK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS09475
gene id: 632348:CALKRO_RS09475
uniprot id: E4SG51
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS04935
gene id: 632348:CALKRO_RS04935
uniprot id: E4SB76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

632348:CALKRO RS10230
gene id: 632348:CALKRO_RS10230
uniprot id: E4SGI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS02135
gene id: 632348:CALKRO_RS02135
uniprot id: E4SE37
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS01820
gene id: 632348:CALKRO_RS01820
uniprot id: E4SDX5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

632348:CALKRO RS01625
gene id: 632348:CALKRO_RS01625
uniprot id: E4SDN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

632348:CALKRO RS07060
gene id: 632348:CALKRO_RS07060
uniprot id: E4SBX8
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

632348:CALKRO RS08100
gene id: 632348:CALKRO_RS08100
uniprot id: E4SFD0
names: Similarity
messages: Belongs to the HupF/HypC family.

632348:CALKRO RS09415
gene id: 632348:CALKRO_RS09415
uniprot id: E4SG39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

632348:CALKRO RS11045
gene id: 632348:CALKRO_RS11045
uniprot id: E4SGZ9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS03175
gene id: 632348:CALKRO_RS03175
uniprot id: E4SEN7
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

632348:CALKRO RS07260
gene id: 632348:CALKRO_RS07260
uniprot id: E4SC55
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

632348:CALKRO RS09155
gene id: 632348:CALKRO_RS09155
uniprot id: E4SFY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

632348:CALKRO RS12145
gene id: 632348:CALKRO_RS12145
uniprot id: E4SHK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

632348:CALKRO RS02185
gene id: 632348:CALKRO_RS02185
uniprot id: E4SE46
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

632348:CALKRO RS06470
gene id: 632348:CALKRO_RS06470
uniprot id: E4SBL3
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

632348:CALKRO RS06860
gene id: 632348:CALKRO_RS06860
uniprot id: E4SBT6
names: Subcellular Location Annotation
messages: Cytoplasm

632348:CALKRO RS02370
gene id: 632348:CALKRO_RS02370
uniprot id: E4SE79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01975
gene id: 632348:CALKRO_RS01975
uniprot id: E4SE06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

632348:CALKRO RS10405
gene id: 632348:CALKRO_RS10405
uniprot id: E4SGM4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

632348:CALKRO RS00235
gene id: 632348:CALKRO_RS00235
uniprot id: E4SCB0
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00990
gene id: 632348:CALKRO_RS00990
uniprot id: E4SD51
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06870
gene id: 632348:CALKRO_RS06870
uniprot id: E4SBT8
names: Similarity
messages: Belongs to the YggT family.

632348:CALKRO RS08775
gene id: 632348:CALKRO_RS08775
uniprot id: E4SFR4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

632348:CALKRO RS03260
gene id: 632348:CALKRO_RS03260
uniprot id: E4SEQ4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

632348:CALKRO RS00785
gene id: 632348:CALKRO_RS00785
uniprot id: E4SCU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

632348:CALKRO RS10025
gene id: 632348:CALKRO_RS10025
uniprot id: E4SGF0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

632348:CALKRO RS09950
gene id: 632348:CALKRO_RS09950
uniprot id: E4SGD6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS00525
gene id: 632348:CALKRO_RS00525
uniprot id: E4SCG7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS08665
gene id: 632348:CALKRO_RS08665
uniprot id: E4SFP3
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

632348:CALKRO RS02315
gene id: 632348:CALKRO_RS02315
uniprot id: E4SE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

632348:CALKRO RS07680
gene id: 632348:CALKRO_RS07680
uniprot id: E4SF49
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

632348:CALKRO RS09055
gene id: 632348:CALKRO_RS09055
uniprot id: E4SFW7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

632348:CALKRO RS10240
gene id: 632348:CALKRO_RS10240
uniprot id: E4SGJ1
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06185
gene id: 632348:CALKRO_RS06185
uniprot id: E4SBF6
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

632348:CALKRO RS09485
gene id: 632348:CALKRO_RS09485
uniprot id: E4SG53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

632348:CALKRO RS05145
gene id: 632348:CALKRO_RS05145
uniprot id: E4SBB1
names: Similarity
messages: Belongs to the TrpC family.

632348:CALKRO RS00430
gene id: 632348:CALKRO_RS00430
uniprot id: E4SCE8
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

632348:CALKRO RS08225
gene id: 632348:CALKRO_RS08225
uniprot id: E4SFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07635
gene id: 632348:CALKRO_RS07635
uniprot id: E4SF40
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

632348:CALKRO RS07570
gene id: 632348:CALKRO_RS07570
uniprot id: E4SF27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

632348:CALKRO RS10610
gene id: 632348:CALKRO_RS10610
uniprot id: E4SGR5
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

632348:CALKRO RS10085
gene id: 632348:CALKRO_RS10085
uniprot id: E4SGG2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

632348:CALKRO RS00895
gene id: 632348:CALKRO_RS00895
uniprot id: E4SCW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

632348:CALKRO RS05265
gene id: 632348:CALKRO_RS05265
uniprot id: E4SCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

632348:CALKRO RS12825
gene id: 632348:CALKRO_RS12825
uniprot id: E4SHW7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

632348:CALKRO RS01530
gene id: 632348:CALKRO_RS01530
uniprot id: E4SDM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

632348:CALKRO RS06275
gene id: 632348:CALKRO_RS06275
uniprot id: E4SBH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

632348:CALKRO RS10320
gene id: 632348:CALKRO_RS10320
uniprot id: E4SGK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

632348:CALKRO RS05575
gene id: 632348:CALKRO_RS05575
uniprot id: E4SCN9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

632348:CALKRO RS09755
gene id: 632348:CALKRO_RS09755
uniprot id: E4SG98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

632348:CALKRO RS09600
gene id: 632348:CALKRO_RS09600
uniprot id: E4SG71
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

632348:CALKRO RS07795
gene id: 632348:CALKRO_RS07795
uniprot id: E4SF71
names: Similarity
messages: Belongs to the fabD family.

632348:CALKRO RS06135
gene id: 632348:CALKRO_RS06135
uniprot id: E4SBE6
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

632348:CALKRO RS09640
gene id: 632348:CALKRO_RS09640
uniprot id: E4SG78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

632348:CALKRO RS09810
gene id: 632348:CALKRO_RS09810
uniprot id: E4SGA9
names: Similarity
messages: Belongs to the UPF0342 family.

632348:CALKRO RS07320
gene id: 632348:CALKRO_RS07320
uniprot id: E4SC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

632348:CALKRO RS07315
gene id: 632348:CALKRO_RS07315
uniprot id: E4SC66
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

632348:CALKRO RS05435
gene id: 632348:CALKRO_RS05435
uniprot id: E4SCL1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

632348:CALKRO RS10125
gene id: 632348:CALKRO_RS10125
uniprot id: E4SGH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

632348:CALKRO RS10050
gene id: 632348:CALKRO_RS10050
uniprot id: E4SGF5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

632348:CALKRO RS08915
gene id: 632348:CALKRO_RS08915
uniprot id: E4SFU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

632348:CALKRO RS07050
gene id: 632348:CALKRO_RS07050
uniprot id: E4SBX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

632348:CALKRO RS09205
gene id: 632348:CALKRO_RS09205
uniprot id: E4SFZ7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

632348:CALKRO RS10135
gene id: 632348:CALKRO_RS10135
uniprot id: E4SGH2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

632348:CALKRO RS04860
gene id: 632348:CALKRO_RS04860
uniprot id: E4SB61
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

632348:CALKRO RS01035
gene id: 632348:CALKRO_RS01035
uniprot id: E4SD60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS03975
gene id: 632348:CALKRO_RS03975
uniprot id: E4SB15
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

632348:CALKRO RS04730
gene id: 632348:CALKRO_RS04730
uniprot id: E4SDR7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

632348:CALKRO RS10220
gene id: 632348:CALKRO_RS10220
uniprot id: E4SGI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

632348:CALKRO RS08310
gene id: 632348:CALKRO_RS08310
uniprot id: E4SFH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

632348:CALKRO RS01245
gene id: 632348:CALKRO_RS01245
uniprot id: E4SDA2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

632348:CALKRO RS06950
gene id: 632348:CALKRO_RS06950
uniprot id: E4SBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

632348:CALKRO RS10385
gene id: 632348:CALKRO_RS10385
uniprot id: E4SGM0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS02900
gene id: 632348:CALKRO_RS02900
uniprot id: E4SEI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

632348:CALKRO RS08165
gene id: 632348:CALKRO_RS08165
uniprot id: E4SFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

632348:CALKRO RS01230
gene id: 632348:CALKRO_RS01230
uniprot id: E4SD99
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS02300
gene id: 632348:CALKRO_RS02300
uniprot id: E4SE65
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

632348:CALKRO RS06405
gene id: 632348:CALKRO_RS06405
uniprot id: E4SBK0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

632348:CALKRO RS10835
gene id: 632348:CALKRO_RS10835
uniprot id: E4SGV9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS01130
gene id: 632348:CALKRO_RS01130
uniprot id: E4SD79
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS02840
gene id: 632348:CALKRO_RS02840
uniprot id: E4SEH0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

632348:CALKRO RS04565
gene id: 632348:CALKRO_RS04565
uniprot id: E4SDH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

632348:CALKRO RS06930
gene id: 632348:CALKRO_RS06930
uniprot id: E4SBV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

632348:CALKRO RS08400
gene id: 632348:CALKRO_RS08400
uniprot id: E4SFJ0
names: Similarity
messages: Belongs to the histone deacetylase family.

632348:CALKRO RS12320
gene id: 632348:CALKRO_RS12320
uniprot id: E4SHM9
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

632348:CALKRO RS05475
gene id: 632348:CALKRO_RS05475
uniprot id: E4SCL9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

632348:CALKRO RS02450
gene id: 632348:CALKRO_RS02450
uniprot id: E4SE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

632348:CALKRO RS01040
gene id: 632348:CALKRO_RS01040
uniprot id: E4SD61
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

632348:CALKRO RS09460
gene id: 632348:CALKRO_RS09460
uniprot id: E4SG48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

632348:CALKRO RS12060
gene id: 632348:CALKRO_RS12060
uniprot id: E4SHI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS08750
gene id: 632348:CALKRO_RS08750
uniprot id: E4SFQ9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

632348:CALKRO RS06595
gene id: 632348:CALKRO_RS06595
uniprot id: E4SBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS13000
gene id: 632348:CALKRO_RS13000
uniprot id: E4SI03
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS02335
gene id: 632348:CALKRO_RS02335
uniprot id: E4SE72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

632348:CALKRO RS04810
gene id: 632348:CALKRO_RS04810
uniprot id: E4SDT1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

632348:CALKRO RS04815
gene id: 632348:CALKRO_RS04815
uniprot id: E4SDT2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS12985
gene id: 632348:CALKRO_RS12985
uniprot id: E4SI00
names: Similarity
messages: Belongs to the ParB family.

632348:CALKRO RS08270
gene id: 632348:CALKRO_RS08270
uniprot id: E4SFG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

632348:CALKRO RS05845
gene id: 632348:CALKRO_RS05845
uniprot id: E4SD04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

632348:CALKRO RS03080
gene id: 632348:CALKRO_RS03080
uniprot id: E4SEL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

632348:CALKRO RS02190
gene id: 632348:CALKRO_RS02190
uniprot id: E4SE47
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

632348:CALKRO RS00170
gene id: 632348:CALKRO_RS00170
uniprot id: E4SC29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

632348:CALKRO RS04940
gene id: 632348:CALKRO_RS04940
uniprot id: E4SB77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

632348:CALKRO RS04900
gene id: 632348:CALKRO_RS04900
uniprot id: E4SB69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

632348:CALKRO RS03160
gene id: 632348:CALKRO_RS03160
uniprot id: E4SEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07495
gene id: 632348:CALKRO_RS07495
uniprot id: E4SCA2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS10325
gene id: 632348:CALKRO_RS10325
uniprot id: E4SGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

632348:CALKRO RS04960
gene id: 632348:CALKRO_RS04960
uniprot id: E4SB81
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

632348:CALKRO RS12425
gene id: 632348:CALKRO_RS12425
uniprot id: E4SHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS00540
gene id: 632348:CALKRO_RS00540
uniprot id: E4SCH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10725
gene id: 632348:CALKRO_RS10725
uniprot id: E4SGT6
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

632348:CALKRO RS05820
gene id: 632348:CALKRO_RS05820
uniprot id: E4SD00
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

632348:CALKRO RS00585
gene id: 632348:CALKRO_RS00585
uniprot id: E4SCQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07580
gene id: 632348:CALKRO_RS07580
uniprot id: E4SF29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

632348:CALKRO RS03120
gene id: 632348:CALKRO_RS03120
uniprot id: E4SEM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

632348:CALKRO RS04580
gene id: 632348:CALKRO_RS04580
uniprot id: E4SDN6
names: Similarity
messages: Belongs to the peptidase S41A family.

632348:CALKRO RS06725
gene id: 632348:CALKRO_RS06725
uniprot id: E4SBR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

632348:CALKRO RS04065
gene id: 632348:CALKRO_RS04065
uniprot id: E4SB33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

632348:CALKRO RS05140
gene id: 632348:CALKRO_RS05140
uniprot id: E4SBB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06515
gene id: 632348:CALKRO_RS06515
uniprot id: E4SBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

632348:CALKRO RS13130
gene id: 632348:CALKRO_RS13130
uniprot id: E4SH39
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

632348:CALKRO RS01195
gene id: 632348:CALKRO_RS01195
uniprot id: E4SD92
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS09735
gene id: 632348:CALKRO_RS09735
uniprot id: E4SG94
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS02715
gene id: 632348:CALKRO_RS02715
uniprot id: E4SEE8
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

632348:CALKRO RS11630
gene id: 632348:CALKRO_RS11630
uniprot id: E4SHA3
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.

632348:CALKRO RS06715
gene id: 632348:CALKRO_RS06715
uniprot id: E4SBQ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS10710
gene id: 632348:CALKRO_RS10710
uniprot id: E4SGT3
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

632348:CALKRO RS02445
gene id: 632348:CALKRO_RS02445
uniprot id: E4SE94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

632348:CALKRO RS12040
gene id: 632348:CALKRO_RS12040
uniprot id: E4SHI2
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

632348:CALKRO RS07780
gene id: 632348:CALKRO_RS07780
uniprot id: E4SF68
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

632348:CALKRO RS06905
gene id: 632348:CALKRO_RS06905
uniprot id: E4SBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

632348:CALKRO RS11700
gene id: 632348:CALKRO_RS11700
uniprot id: E4SHB7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

632348:CALKRO RS09085
gene id: 632348:CALKRO_RS09085
uniprot id: E4SFX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS10075
gene id: 632348:CALKRO_RS10075
uniprot id: E4SGG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS04930
gene id: 632348:CALKRO_RS04930
uniprot id: E4SB75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

632348:CALKRO RS07585
gene id: 632348:CALKRO_RS07585
uniprot id: E4SF30
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

632348:CALKRO RS00420
gene id: 632348:CALKRO_RS00420
uniprot id: E4SCE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS04805
gene id: 632348:CALKRO_RS04805
uniprot id: E4SDT0
names: Similarity
messages: Belongs to the peptidase M18 family.

632348:CALKRO RS05800
gene id: 632348:CALKRO_RS05800
uniprot id: E4SCZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

632348:CALKRO RS09520
gene id: 632348:CALKRO_RS09520
uniprot id: E4SG60
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

632348:CALKRO RS05935
gene id: 632348:CALKRO_RS05935
uniprot id: E4SD21
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

632348:CALKRO RS06385
gene id: 632348:CALKRO_RS06385
uniprot id: E4SBJ6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

632348:CALKRO RS10810
gene id: 632348:CALKRO_RS10810
uniprot id: E4SGV3
names: Similarity
messages: Belongs to the class-I fumarase family.

632348:CALKRO RS06145
gene id: 632348:CALKRO_RS06145
uniprot id: E4SBE8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

632348:CALKRO RS11990
gene id: 632348:CALKRO_RS11990
uniprot id: E4SHH2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS04495
gene id: 632348:CALKRO_RS04495
uniprot id: E4SDG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

632348:CALKRO RS02930
gene id: 632348:CALKRO_RS02930
uniprot id: E4SEI6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

632348:CALKRO RS12165
gene id: 632348:CALKRO_RS12165
uniprot id: E4SHK5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

632348:CALKRO RS07295
gene id: 632348:CALKRO_RS07295
uniprot id: E4SC62
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

632348:CALKRO RS09390
gene id: 632348:CALKRO_RS09390
uniprot id: E4SG34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

632348:CALKRO RS06390
gene id: 632348:CALKRO_RS06390
uniprot id: E4SBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

632348:CALKRO RS02330
gene id: 632348:CALKRO_RS02330
uniprot id: E4SE71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.

632348:CALKRO RS03240
gene id: 632348:CALKRO_RS03240
uniprot id: E4SEQ0
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

632348:CALKRO RS01685
gene id: 632348:CALKRO_RS01685
uniprot id: E4SDU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

632348:CALKRO RS06925
gene id: 632348:CALKRO_RS06925
uniprot id: E4SBU9
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

632348:CALKRO RS13010
gene id: 632348:CALKRO_RS13010
uniprot id: E4SI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

632348:CALKRO RS00305
gene id: 632348:CALKRO_RS00305
uniprot id: E4SCC3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS04060
gene id: 632348:CALKRO_RS04060
uniprot id: E4SB32
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS06050
gene id: 632348:CALKRO_RS06050
uniprot id: E4SBD5
names: Similarity
messages: Belongs to the UPF0047 family.

632348:CALKRO RS02030
gene id: 632348:CALKRO_RS02030
uniprot id: E4SE16
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06840
gene id: 632348:CALKRO_RS06840
uniprot id: E4SBT3
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

632348:CALKRO RS02700
gene id: 632348:CALKRO_RS02700
uniprot id: E4SEE5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS03030
gene id: 632348:CALKRO_RS03030
uniprot id: E4SEK7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

632348:CALKRO RS05110
gene id: 632348:CALKRO_RS05110
uniprot id: E4SBA4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

632348:CALKRO RS11920
gene id: 632348:CALKRO_RS11920
uniprot id: E4SHF8
names: Similarity
messages: Belongs to the PspA/IM30 family.

632348:CALKRO RS08255
gene id: 632348:CALKRO_RS08255
uniprot id: E4SFG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS11030
gene id: 632348:CALKRO_RS11030
uniprot id: E4SGZ6
names: Similarity
messages: Belongs to the hemerythrin family.

632348:CALKRO RS06160
gene id: 632348:CALKRO_RS06160
uniprot id: E4SBF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

632348:CALKRO RS09375
gene id: 632348:CALKRO_RS09375
uniprot id: E4SG31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

632348:CALKRO RS04405
gene id: 632348:CALKRO_RS04405
uniprot id: E4SDE3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07065
gene id: 632348:CALKRO_RS07065
uniprot id: E4SBX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

632348:CALKRO RS05590
gene id: 632348:CALKRO_RS05590
uniprot id: E4SCP2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

632348:CALKRO RS09315
gene id: 632348:CALKRO_RS09315
uniprot id: E4SG19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

632348:CALKRO RS10850
gene id: 632348:CALKRO_RS10850
uniprot id: E4SGW2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

632348:CALKRO RS05860
gene id: 632348:CALKRO_RS05860
uniprot id: E4SD07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

632348:CALKRO RS02405
gene id: 632348:CALKRO_RS02405
uniprot id: E4SE86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

632348:CALKRO RS04190
gene id: 632348:CALKRO_RS04190
uniprot id: E4SB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS00225
gene id: 632348:CALKRO_RS00225
uniprot id: E4SCA8
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00295
gene id: 632348:CALKRO_RS00295
uniprot id: E4SCC1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS04175
gene id: 632348:CALKRO_RS04175
uniprot id: E4SB55
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS11405
gene id: 632348:CALKRO_RS11405
uniprot id: E4SH62
names: Similarity
messages: Belongs to the ThiD family.

632348:CALKRO RS02585
gene id: 632348:CALKRO_RS02585
uniprot id: E4SEC2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS06970
gene id: 632348:CALKRO_RS06970
uniprot id: E4SBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

632348:CALKRO RS02420
gene id: 632348:CALKRO_RS02420
uniprot id: E4SE89
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS08725
gene id: 632348:CALKRO_RS08725
uniprot id: E4SFQ4
names: Similarity
messages: Belongs to the intimin/invasin family.

632348:CALKRO RS08265
gene id: 632348:CALKRO_RS08265
uniprot id: E4SFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

632348:CALKRO RS06480
gene id: 632348:CALKRO_RS06480
uniprot id: E4SBL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS01125
gene id: 632348:CALKRO_RS01125
uniprot id: E4SD78
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

632348:CALKRO RS12410
gene id: 632348:CALKRO_RS12410
uniprot id: E4SHP7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS02435
gene id: 632348:CALKRO_RS02435
uniprot id: E4SE92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

632348:CALKRO RS13015
gene id: 632348:CALKRO_RS13015
uniprot id: E4SI06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

632348:CALKRO RS04915
gene id: 632348:CALKRO_RS04915
uniprot id: E4SB72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

632348:CALKRO RS06410
gene id: 632348:CALKRO_RS06410
uniprot id: E4SBK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

632348:CALKRO RS02250
gene id: 632348:CALKRO_RS02250
uniprot id: E4SE56
names: Similarity
messages: Belongs to the HepT RNase toxin family.

632348:CALKRO RS04955
gene id: 632348:CALKRO_RS04955
uniprot id: E4SB80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

632348:CALKRO RS04090
gene id: 632348:CALKRO_RS04090
uniprot id: E4SB39
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

632348:CALKRO RS09635
gene id: 632348:CALKRO_RS09635
uniprot id: E4SG77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

632348:CALKRO RS04520
gene id: 632348:CALKRO_RS04520
uniprot id: E4SDG6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS08760
gene id: 632348:CALKRO_RS08760
uniprot id: E4SFR1
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

632348:CALKRO RS06685
gene id: 632348:CALKRO_RS06685
uniprot id: E4SBQ4
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS09010
gene id: 632348:CALKRO_RS09010
uniprot id: E4SFW0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

632348:CALKRO RS07775
gene id: 632348:CALKRO_RS07775
uniprot id: E4SF67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

632348:CALKRO RS11725
gene id: 632348:CALKRO_RS11725
uniprot id: E4SHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

632348:CALKRO RS08005
gene id: 632348:CALKRO_RS08005
uniprot id: E4SFB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

632348:CALKRO RS11350
gene id: 632348:CALKRO_RS11350
uniprot id: E4SH53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

632348:CALKRO RS04660
gene id: 632348:CALKRO_RS04660
uniprot id: E4SDQ2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

632348:CALKRO RS09075
gene id: 632348:CALKRO_RS09075
uniprot id: E4SFX1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

632348:CALKRO RS07800
gene id: 632348:CALKRO_RS07800
uniprot id: E4SF72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

632348:CALKRO RS08365
gene id: 632348:CALKRO_RS08365
uniprot id: E4SFI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

632348:CALKRO RS00330
gene id: 632348:CALKRO_RS00330
uniprot id: E4SCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS11620
gene id: 632348:CALKRO_RS11620
uniprot id: E4SHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

632348:CALKRO RS08040
gene id: 632348:CALKRO_RS08040
uniprot id: E4SFB8
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

632348:CALKRO RS09300
gene id: 632348:CALKRO_RS09300
uniprot id: E4SG16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

632348:CALKRO RS00645
gene id: 632348:CALKRO_RS00645
uniprot id: E4SCR3
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS00005
gene id: 632348:CALKRO_RS00005
uniprot id: E4SBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

632348:CALKRO RS09455
gene id: 632348:CALKRO_RS09455
uniprot id: E4SG47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07100
gene id: 632348:CALKRO_RS07100
uniprot id: E4SBY6
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

632348:CALKRO RS05880
gene id: 632348:CALKRO_RS05880
uniprot id: E4SD11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

632348:CALKRO RS00480
gene id: 632348:CALKRO_RS00480
uniprot id: E4SCF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS09925
gene id: 632348:CALKRO_RS09925
uniprot id: E4SGD1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

632348:CALKRO RS09915
gene id: 632348:CALKRO_RS09915
uniprot id: E4SGC9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

632348:CALKRO RS02460
gene id: 632348:CALKRO_RS02460
uniprot id: E4SE97
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

632348:CALKRO RS07850
gene id: 632348:CALKRO_RS07850
uniprot id: E4SF83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

632348:CALKRO RS06260
gene id: 632348:CALKRO_RS06260
uniprot id: E4SBH1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

632348:CALKRO RS02730
gene id: 632348:CALKRO_RS02730
uniprot id: E4SEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS07535
gene id: 632348:CALKRO_RS07535
uniprot id: E4SF20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

632348:CALKRO RS01375
gene id: 632348:CALKRO_RS01375
uniprot id: E4SDJ3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

632348:CALKRO RS07565
gene id: 632348:CALKRO_RS07565
uniprot id: E4SF26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

632348:CALKRO RS06735
gene id: 632348:CALKRO_RS06735
uniprot id: E4SBR3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS01090
gene id: 632348:CALKRO_RS01090
uniprot id: E4SD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS03095
gene id: 632348:CALKRO_RS03095
uniprot id: E4SEM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

632348:CALKRO RS09335
gene id: 632348:CALKRO_RS09335
uniprot id: E4SG23
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS06225
gene id: 632348:CALKRO_RS06225
uniprot id: E4SBG4
names: Similarity
messages: Belongs to the UPF0111 family.

632348:CALKRO RS01900
gene id: 632348:CALKRO_RS01900
uniprot id: E4SDZ1
names: Cofactor
messages: Binds 1 zinc ion per subunit.

632348:CALKRO RS00075
gene id: 632348:CALKRO_RS00075
uniprot id: E4SC12
names: Similarity
messages: Belongs to the peptidase S24 family.

632348:CALKRO RS08930
gene id: 632348:CALKRO_RS08930
uniprot id: E4SFU6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

632348:CALKRO RS07430
gene id: 632348:CALKRO_RS07430
uniprot id: E4SC89
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

632348:CALKRO RS05215
gene id: 632348:CALKRO_RS05215
uniprot id: E4SBC3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

632348:CALKRO RS05445
gene id: 632348:CALKRO_RS05445
uniprot id: E4SCL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

632348:CALKRO RS04875
gene id: 632348:CALKRO_RS04875
uniprot id: E4SB64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

632348:CALKRO RS09820
gene id: 632348:CALKRO_RS09820
uniprot id: E4SGB1
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS06395
gene id: 632348:CALKRO_RS06395
uniprot id: E4SBJ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

632348:CALKRO RS02670
gene id: 632348:CALKRO_RS02670
uniprot id: E4SED9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

632348:CALKRO RS10675
gene id: 632348:CALKRO_RS10675
uniprot id: E4SGS8
names: Similarity
messages: Belongs to the leucine-binding protein family.

632348:CALKRO RS11515
gene id: 632348:CALKRO_RS11515
uniprot id: E4SH84
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

632348:CALKRO RS05460
gene id: 632348:CALKRO_RS05460
uniprot id: E4SCL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

632348:CALKRO RS02050
gene id: 632348:CALKRO_RS02050
uniprot id: E4SE20
names: Similarity
messages: Belongs to the UPF0236 family.

632348:CALKRO RS04880
gene id: 632348:CALKRO_RS04880
uniprot id: E4SB65
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

632348:CALKRO RS02870
gene id: 632348:CALKRO_RS02870
uniprot id: E4SEH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

632348:CALKRO RS10070
gene id: 632348:CALKRO_RS10070
uniprot id: E4SGF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

632348:CALKRO RS03580
gene id: 632348:CALKRO_RS03580
uniprot id: E4SEW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

632348:CALKRO RS03070
gene id: 632348:CALKRO_RS03070
uniprot id: E4SEL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

632348:CALKRO RS10080
gene id: 632348:CALKRO_RS10080
uniprot id: E4SGG1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

632348:CALKRO RS05815
gene id: 632348:CALKRO_RS05815
uniprot id: E4SCZ9
names: Similarity
messages: Belongs to the SleB family.

632348:CALKRO RS05855
gene id: 632348:CALKRO_RS05855
uniprot id: E4SD06
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

632348:CALKRO RS00515
gene id: 632348:CALKRO_RS00515
uniprot id: E4SCG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

632348:CALKRO RS09525
gene id: 632348:CALKRO_RS09525
uniprot id: E4SG61
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

632348:CALKRO RS00015
gene id: 632348:CALKRO_RS00015
uniprot id: E4SBZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

632348:CALKRO RS07615
gene id: 632348:CALKRO_RS07615
uniprot id: E4SF36
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

632348:CALKRO RS08240
gene id: 632348:CALKRO_RS08240
uniprot id: E4SFF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

632348:CALKRO RS11270
gene id: 632348:CALKRO_RS11270
uniprot id: E4SH42
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

632348:CALKRO RS02645
gene id: 632348:CALKRO_RS02645
uniprot id: E4SED4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

632348:CALKRO RS05505
gene id: 632348:CALKRO_RS05505
uniprot id: E4SCM3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

632348:CALKRO RS01645
gene id: 632348:CALKRO_RS01645
uniprot id: E4SDN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

632348:CALKRO RS12525
gene id: 632348:CALKRO_RS12525
uniprot id: E4SHS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

632348:CALKRO RS07820
gene id: 632348:CALKRO_RS07820
uniprot id: E4SF76
names: Similarity
messages: Belongs to the UPF0473 family.

632348:CALKRO RS03295
gene id: 632348:CALKRO_RS03295
uniprot id: E4SER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

632348:CALKRO RS05865
gene id: 632348:CALKRO_RS05865
uniprot id: E4SD08
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

632348:CALKRO RS05260
gene id: 632348:CALKRO_RS05260
uniprot id: E4SCI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

632348:CALKRO RS06445
gene id: 632348:CALKRO_RS06445
uniprot id: E4SBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

632348:CALKRO RS07805
gene id: 632348:CALKRO_RS07805
uniprot id: E4SF73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

632348:CALKRO RS04600
gene id: 632348:CALKRO_RS04600
uniprot id: E4SDP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

632348:CALKRO RS00850
gene id: 632348:CALKRO_RS00850
uniprot id: E4SCV3
names: Subcellular Location Annotation
messages: Membrane

632348:CALKRO RS09715
gene id: 632348:CALKRO_RS09715
uniprot id: E4SG90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

632348:CALKRO RS12355
gene id: 632348:CALKRO_RS12355
uniprot id: E4SHN6
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

632348:CALKRO RS07175
gene id: 632348:CALKRO_RS07175
uniprot id: E4SC38
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

632348:CALKRO RS07525
gene id: 632348:CALKRO_RS07525
uniprot id: E4SF18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

632348:CALKRO RS07905
gene id: 632348:CALKRO_RS07905
uniprot id: E4SF92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

632348:CALKRO RS10160
gene id: 632348:CALKRO_RS10160
uniprot id: E4SGH8
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

632348:CALKRO RS00870
gene id: 632348:CALKRO_RS00870
uniprot id: E4SCV7
names: Similarity
messages: Belongs to the glutamate synthase family.

632348:CALKRO RS07015
gene id: 632348:CALKRO_RS07015
uniprot id: E4SBW9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

632348:CALKRO RS07195
gene id: 632348:CALKRO_RS07195
uniprot id: E4SC42
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

632348:CALKRO RS12940
gene id: 632348:CALKRO_RS12940
uniprot id: E4SHZ1
names: Similarity
messages: Belongs to the class-I fumarase family.

632348:CALKRO RS09405
gene id: 632348:CALKRO_RS09405
uniprot id: E4SG37
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

632348:CALKRO RS07225
gene id: 632348:CALKRO_RS07225
uniprot id: E4SC48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

632348:CALKRO RS07790
gene id: 632348:CALKRO_RS07790
uniprot id: E4SF70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

632348:CALKRO RS06555
gene id: 632348:CALKRO_RS06555
uniprot id: E4SBN0
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

632348:CALKRO RS09325
gene id: 632348:CALKRO_RS09325
uniprot id: E4SG21
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

632348:CALKRO RS06350
gene id: 632348:CALKRO_RS06350
uniprot id: E4SBI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

632348:CALKRO RS00710
gene id: 632348:CALKRO_RS00710
uniprot id: E4SCS5
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

632348:CALKRO RS01745
gene id: 632348:CALKRO_RS01745
uniprot id: E4SDW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

632348:CALKRO RS11010
gene id: 632348:CALKRO_RS11010
uniprot id: E4SGZ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

632348:CALKRO RS06875
gene id: 632348:CALKRO_RS06875
uniprot id: E4SBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

632348:CALKRO RS01320
gene id: 632348:CALKRO_RS01320
uniprot id: E4SDI3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

632348:CALKRO RS05015
gene id: 632348:CALKRO_RS05015
uniprot id: E4SB90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.